ライフサイエンスコーパス: cyclohexyl

1 OD = 1,5-cyclooctadiene, py = pyridine, Cy = cyclohexyl).

2 decyl, n-tetradecyl, n-octadecyl, phenyl, or cyclohexyl).

3 PAu)(2)(2,7-naphthalenediyl) (3), where Cy = cyclohexyl.

4 after oxidative workup of the 3-octene and 1-cyclohexyl-1-butene hydroborations.

5 of alkenes such as 3-hexene, 3-octene, and 1-cyclohexyl-1-butene with the N-heterocyclic carbene (NHC

6 pproaching equilibrium, a secondary product, cyclohexyl-1-cyclohexene is formed.

7 genotype 1b (isolate J4) in the detergent 6-cyclohexyl-1-hexylphosphocholine (Cyclofos-6) and p7 der

8 liposome formulation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), an effective agent used

9 en between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vincristine (PCV) a

10 he chemotherapeutic drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in vitro.

11 ourea; BCNU], lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; CCNU], and streptozotocin, to

12 n the relatively mild and harsh detergents 5-cyclohexyl-1-pentyl-beta-D-maltoside and n-octyl-beta-D-

13 -cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-ind ole-2-carboxamide (SB269652) (1) adop

14 tor (A(3)AR) positive allosteric modulator 2-cyclohexyl-1H-imidazo[4,5-c]quinolin-4-(3,4-dichlorophen

15 gen, as in 3-{[5-(adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carbonyl]amino }benzoic acid (

16 1848 (6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione).

17 ano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-1H- indole-2-carboxamide (SB269652), a compo

18 Integrating DMS-SHAPE data and including 1-cyclohexyl(2-morpholinoethyl) carbodiimide metho-p-tolue

19 N-cyclododecyl)4][Pt(CN)4] (1), [(phen)Pt(CN-cyclohexyl)2][Pt(CN)4] (2), and [Pt(CN-n-tetradecyl)4][P

20 5 nM were observed for 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyranone.

21 everal novel structural variants including 2-cyclohexyl, 2-naphthyl, and 6-carbomethoxy analogs also

22 selective adenosine A1 receptor agonist, N6-cyclohexyl-2'-O-methyladenosine (SDZ-WAG 994).

23 A series of modified N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyri

24 (S, S)-3-Cyclohexyl-2-[[5-(2, 4-difluorophenyl)-2-[(phosphonometh

25 ctrolyte (BGE) consisting of 10 mmol L(-1) N-cyclohexyl-2-aminoethanesulfonic acid (CHES) and 5 mmol

26 8% (PR >99, >99, 9.4, >99, 14, and 7.5) with cyclohexyl-2-pyridinecarboxylate, cycloheptyl-2-pyridine

27 der ambient conditions in solvents such as N-cyclohexyl-2-pyrrolidone (CHP).

28 ors 1-ethyl-2-benzimidazolinone (1-EBIO) and cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methylpyrimi

29 pound 2 (1-(1-(4-acetylpiperazine-1-carbonyl)cyclohexyl)-3-(p-tolyl)urea) are competitive inhibitors

30 d enantioselective non-directed oxidation of cyclohexyl-3,5-meso diethers using aqueous H2O2.

31 Escherichia coli and Candida albicans with 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-to

32 The probes include 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-to

33 bination of dimethylsulfate, kethoxal, and 1-cyclohexyl-3-(2-morpholinoethyl)-carbodiimide metho-p-to

34 reagents, such as dimethyl sulfate (DMS), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

35 es, such as dimethylsulfate, kethoxal, and 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

36 cation interference with dimethyl sulfate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

37 hylisatoic anhydride, dimethyl sulfate and 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-tol

38 This method utilizes 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide to derivati

39 We now show that the sEH inhibitor 1-cyclohexyl-3-dodecyl urea (CDU) inhibits human VSM cell

40 ministration of the specific SEH inhibitor 1-cyclohexyl-3-dodecylurea (CDU, 3 mg/d) for 10 d lowered

41 yrrolidines on reacting with cis-2-benzoyl-N-cyclohexyl-3-phenylaziridine, whereas with the other all

42 hem were 2-benzothiazole sulfonic acid and 1-cyclohexyl-3-phenylurea from tire wear and denatonium us

43 ogue [piperidyl-3,4-(3)H(N)]-N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([(3)H]TCP), [(3)H]ethidium,

44 -6-(cyclopropylmethoxy)-N-[(1R,2R)-2-hydroxy-cyclohexyl]-3-pyr idinecarboxamide] and its peripherally

45 ormation of the high-valent iron complex [Fe(cyclohexyl)4 ] from Fe(II) under reducing conditions is

46 ering compounds: picrotoxin, PF-670462 (4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimi

47 us work, where high-affinity sigma2 ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-

48 Herein, we describe the discovery of 7-cyclohexyl-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-7,8-

49 carbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit co

50 because the DpT analog, di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), does not

51 x of our lead compound, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), which is

52 rally related analogue, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC).

53 3-thiosemicarbazone and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone, which markedly

54 tastasis suppressor for di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone.

55 o-1, 2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarbo xamide (24, SB-277011).

56 no-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl] cyclohexyl]-4-quinolininecarboxamide (SB-277011-A) was a

57 (2-[(1S,2R,5S)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phe nol) induced a pro

58 [2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phe nol], and HU-210 [

59 zotriazoles 2, 5, and 8 or 1-[1-(heterocycyl)cyclohexyl]-5-phenyltetrazole (12 and 14).

60 ylethyl (4), (trimethylsilyl)methyl (5), and cyclohexyl (6).

61 The 6-cyclohexyl-6-phenyl derivative 3b, with a cis configurat

62 ceptor antagonist 2R,4R,5S-(2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid) (NPC 17742) or ci

63 thyl-2-(4-(trifluoromethyl)phenylsulfonyloxy)cyclohexyl acetate simultaneously improves the resolutio

64 ning ~400 acrylate polymers, poly(tert-butyl cyclohexyl acrylate) was selected for its biofilm- and e

65 .34 nM and also inhibits the effects of N(6)-cyclohexyl-adenosine and 2-chloro-N(6)-(3-iodobenzyl)-5'

66 lycon functionality with the highly reactive cyclohexyl aglycon functionality.

67 ulations predicted that the positions of the cyclohexyl/Ala2 and Pro-NH2 moieties relative to < gluta

68 esized a pair of conformationally restricted cyclohexyl/Ala2-TRH analogues.

69 Unrestricted cyclohexyl/Ala2-TRH exhibited a 650-fold lower affinity

70 ydrazones [proline-phenylalanine or proline-(cyclohexyl)alanine], which reversibly combine through hy

71 With 3-[(2)H(11)-cyclohexyl]alanine as the substrate, the isotope effect

72 the hydroxylation of 3-[1,2,3,4,5,6-(2)H(6)-cyclohexyl]alanine.

73 methyl alpha-D-galactopyranoside, binding of cyclohexyl alpha-D-galactopyranoside to lactose permease

74 The N-cyclohexyl amide 14 represents a direct methine for nitr

75 afa(Cy))(3)Fe]OTf(2) (N(afa(Cy))(3) = tris(5-cyclohexyl-amineazafulvene-2-methyl)amine, OTf = triflat

76 an be applied for the synthesis of different cyclohexyl amino ketones and tetrahydropyrans possessing

77 lic alcohol, in similar amounts as the known cyclohexyl analogue 1.

78 2-(4-(Benzoylamino)cyclohexyl) analogues 23 and 24 were weak negative A(3)A

79 as diuretics, a series of 1,4-substituted 8-cyclohexyl and 8-bicyclo[2.2.2]octylxanthines were inves

80 The primary amines 6b and 7 bearing a cyclohexyl and a phenyl ring or two phenyl rings in posi

81 The binding affinities of a variety of cyclohexyl and bicyclo[2.2.2]octylxanthines for the rat

82 )(2)N(Bz)(2))(2)](BF(4))(2), 6b, (where Cy = cyclohexyl and Bz = benzyl) is a distorted square planar

83 (Cy)N(2)(Bz))(2)](BF(4))(2), 3b (where Cy is cyclohexyl and Bz is benzyl), the initial step is the re

84 Computational studies also suggest that cyclohexyl and cycloheptyl carbene systems are slightly

85 A wide range of cyclohexyl and linear aliphatic amines could be fluorina

86 ted by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wher

87 y contrast, [Rh(CO)(PCy(3))Tp(Me2)] (3, Cy = cyclohexyl) and [Rh(PPh(3))(2)Tp(Me2)] (4) display elect

88 rs, i.e. Au28(S-c-C6H11)20 (where -c-C6H11 = cyclohexyl) and Au28(SPh-(t)Bu)20 (where -Ph-(t)Bu = 4-t

89 dditives was performed, and HCl.PCy(3) (Cy = cyclohexyl) and HCl.P-t-Bu(2)Et were in general found to

90 where R = methyl, isopropyl, tert-butyl, and cyclohexyl) and rhodium catalyst precursor compounds (in

91 isobutyl, pinacolyl (3,3-dimethyl-2-butyl), cyclohexyl, and 2-ethylhexyl).

92 ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, and cyclohexoxy substituents.

93 kifunensine analogues (including N-methyl, N-cyclohexyl, and N-bis(hydroxymethyl)methyl) and 2-desoxa

94 0 % (R=Ph) to greater than 90 % (R=n-C4 H9 , cyclohexyl, and PhCH2 CH2 ).

95 gent metabolites ethyl, isopropyl, isobutyl, cyclohexyl, and pinacolyl methylphosphonic acid has been

96 In the case of R(2) = aryl, cyclohexyl, and tert-butyl, mono coupling was observed,

97 The cyclohexyl- and phenethyl-substituted esters, 8c and 8g,

98 ereoselective multigram scale preparation of cyclohexyl- and phenyl thioglycosides of 2-azido-2-deoxy

99 nic acids used in this work included ethyl-, cyclohexyl- and pinacolyl methylphosphonic acid, first p

100 l-, cyclopropylmethyl-, isopropyl-, benzyl-, cyclohexyl-, and 2-hydroxyethylamine gave N(6)-alkyl com

101 clohexyl-, diisobutyl-, diethyl-, diphenyl-, cyclohexyl-, and phenylphosphine.

102 nthesis and application of a novel lithium N-cyclohexyl anilide (LiCyan).

103 ylmenthyl (Corey) and trans-2-(beta-naphthyl)cyclohexyl auxiliaries, using isobutyl iodide and benzyl

104 angman framework, the stereochemistry of the cyclohexyl backbone of the salen platform is revealed in

105 )-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]ben zeneacetamide methanesulfonate.

106 Dehydration of ortho-arylated N-cyclohexyl-benzamides by (CF3CO)2O results in efficient

107 )-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze neacetamide hydrochloride (200 nmol),

108 )-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benzene-acetamide methanesulfonate (U-50,488

109 )-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneac etamide [(-)U50,488H] caused desens

110 s-3, 4-dichloro-N-methyl-N-[2-(1-pyrolidinyl)cyclohexyl] benzeneaceamide methanesulfonate (U50,488H).

111 -3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetam ide methanesulfonate (1 microm)

112 s-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benzeneacetam ide methane sulfonate (U50,488

113 s-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetam ide] (0.3 mg/kg, i.p.) suppres

114 -3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methanesulfonate hydrate wa

115 /-)-3,4-dichloro-N-methyl-N-[2-(pyrrolidinyl)cyclohexyl] benzeneacetamide methanesulfonate), inhibite

116 )-3,4- dichloro-N-methyl-N-[2-(1-pyrrolidiny)cyclohexyl]benzeneacetamide (U50,488H) enhanced the asso

117 s-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide (U50488) and the KOR-depend

118 s-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benzeneacetamide methane sulfonate) signific

119 cloisomerization of acyclic dienyl esters to cyclohexyl beta-lactones.

120 tes (92-98% ee), with the exception of alpha-cyclohexyl-beta-phenylvinyl acetate which exhibited a lo

121 The cyclohexyl-BIQ-copper complex is an efficient catalyst f

122 tion of [Ni(P(Cy)(2)N(Bn)(2)H)(2)](2+) (Cy = cyclohexyl, Bn = benzyl) species formed during the oxida

123 provide the first spectroscopic evidence of cyclohexyl (C(6)H(11)) as a reactive surface intermediat

124 R(3)P)Ag[closo-1-H-CB(11)Me(11)] [R = Ph, 2; cyclohexyl (C(6)H(11)), 3; (3,5-Me(2)-C(6)H(3)), 4].

125 e Ni(0) complex (Cy3P)2Ni(eta(2)-C2H4) (Cy = cyclohexyl), C-P bond cleavage of the alkyne ligand resu

126 ropyl derivative of Bingel and a diisopropyl cyclohexyl C60 alcohol (4a) as synthesized by Ganapathi

127 te was significantly lower than that for the cyclohexyl carbamate derived from URB597.

128 -4-(2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)carbamate (4).

129 arylcarbamate-based FAAH inhibitors, URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) and UR

130 nstrates that the reactive electrophile, the cyclohexyl carbenium ion, is directly formed in a proton

131 pared to the corresponding values for cyclic cyclohexyl carbonate and poly(cyclohexylene carbonate) p

132 er and only small quantities of trans-cyclic cyclohexyl carbonate, under similar conditions propylene

133 f antiviral activity, we discovered a set of cyclohexyl carboxylic acid analogues, highlighted by VX-

134 h all rings sizes could be deprotonated, the cyclohexyl case was impractically slow, and the cyclopen

135 [(C(6)H(6))(PCy(3))(CO)RuH](+)BF(4)(-) (Cy, cyclohexyl) catalyzes the alkylation in solution within

136 {PCy2 (o-biphenyl)}Au(NCMe)](+) SbF6 (-) (Cy=cyclohexyl) catalyzes the intermolecular, anti-Markovnik

137 significant intermediate is the A/B-bicyclic cyclohexyl cation (III), from which two asynchronous con

138 This is followed by proton transfer from the cyclohexyl cation or by addition of the cyclohexyl catio

139 the cyclohexyl cation or by addition of the cyclohexyl cation to the pyridine nitrogen atom in the i

140 y labeled products, thus suggesting that the cyclohexyl cation undergoes a 1,2-hydride shift competit

141 mers ("hyperconjomers") of delta-substituted cyclohexyl cations (b) and natural bond orbital (NBO) an

142 formational equilibrium of delta-substituted cyclohexyl cations.

143 netriaminepentaacetic acid (DTPA) derivative cyclohexyl-(CHX)-A", for 200 cGy TBI.

144 decay occurs through energy transfer to the cyclohexyl co-product within the solvent cage, and slowe

145 The C(5)-cyclohexyl compound 2c (L-736,380) dose-dependently inhi

146 nversion of the cyclobutyl analogue 1 to its cyclohexyl constitutional isomer 5 via a vinyl cyclobuta

147 es displayed lower regioselectivity than the cyclohexyl counterparts presumably due to increased plan

148 Reactions between phosphines with small cyclohexyl- (Cy) or isopropyl- ((i)Pr) groups and the tr

149 ectivities were obtained in the oxidation of cyclohexyl, cycloheptyl, cyclooctyl, 1-pentyl, 1-hexyl,

150 al chelating reagent based on a preorganized cyclohexyl derivative of DTPA (CHX-A'') has been develop

151 Binding curves obtained with DTPA and a cyclohexyl derivative of DTPA in the presence and absenc

152 of a series of 1-Z-pentyl, 1-Z-propyl, and Z-cyclohexyl derivatives and of a series of N-alkylamides

153 With cyclohexyl derivatives, alpha-CH activation is only obse

154 lide (90)Y was coupled by the chelator trans-cyclohexyl-diethylene-triamine-pentaacetic acid (CHX-A''

155 B' and CHX-B") of 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaaceti c acid (CHX-DTPA

156 nanoparticles with glutardialdehyde (GDA) or cyclohexyl-diglycidyl ether (CDGE) linkers, which have n

157 Di-substituted cyclohexyl (DSC) derivatives inhibit the voltage-gated p

158 , which is representative of a disubstituted cyclohexyl (DSC) template, displays a K(i) of ca. 300 nM

159 Y(III) complexes of a pair of diasteriomeric cyclohexyl-DTPA ligands.

160 hibitors [[1,1-biphenyl]-3-yl-carbamic acid, cyclohexyl ester (URB602) and MAFP (methylarachidonyl fl

161 5,6,7-tetrahydro-indazol -1-yl)-phenylamino]-cyclohexyl ester methanesulfonate (SNX-5422, 10) was ora

162 NCH(2)CH(2)N bridgehead, the phenyl and the cyclohexyl esters prefer the out conformation, whereas w

163 From these studies trans-2-[[4-(1H-3-indolyl)cyclohexyl]ethyl]-4- (2-pyridinyl)piperazine (30a) was s

164 hat are isomeric or nearly isomeric with the cyclohexyl example; each has four sp(3) carbons in the s

165 endent on exogenously supplied CHC for omega-cyclohexyl fatty acid production.

166 r production of significant amounts of omega-cyclohexyl fatty acids (as high as 49% of total fatty ac

167 y is also observed in trace amounts of omega-cyclohexyl fatty acids (typically less than 1% of total

168 se AsuC15 limits the cellular level of omega-cyclohexyl fatty acids and likely maintains homeostasis

169 he wild-type strain, could not produce omega-cyclohexyl fatty acids but was still able to grow effici

170 Content of cyclopropyl and omega-cyclohexyl fatty acids of microbial origin, respectively

171 hed tertiary phosphine sulfide, possessing a cyclohexyl fragment at the phosphorus.

172 ino)cyclohexanol (vesamicol, 1) in which the cyclohexyl fragment was replaced with an N-acyl or N-alk

173 a monoalkyl (methyl or t-butyl) substituted cyclohexyl fragment, have been synthesized and fully cha

174 ylglycolide) (PBnMA-PDCG) and PBnMA-b-poly(l-cyclohexyl glycolide) (PBnMA-PLCG), were synthesized for

175 ther protoadamantyl 4, homoadamantyl 5, or a cyclohexyl group 6, were synthesized and their thermal a

176 b (93:7) in which the large substituent is a cyclohexyl group and the medium substituent is a methyl

177 mines, the so-called NiCyArg complex, with a cyclohexyl group at the phosphine and an arginine substi

178 The chair conformation of the cyclohexyl group is clearly resolved.

179 The 2-cyclohexyl group is positioned "upward" within a small h

180 The cyclohexyl group of Ches binds in the hydrophobic pocket

181 es of this complex and an analogue where the cyclohexyl group was replaced with a phenyl group.

182 ak interactions between its phenyl group (or cyclohexyl group) and the carboxylate group.

183 1-enyl, 2-methylpropyl, (E)-prop-1-enyl, and cyclohexyl groups at the C-3' position are also prepared

184 us has been decorated with 2,6-dihaloaryl or cyclohexyl groups at the methylene at C6, alkyl- or (ary

185 The N-propyl and N-cyclohexyl groups generate deep cavity cavitands.

186 solvents, owing to the rotational freedom of cyclohexyl groups paired with their large polarizability

187 the following order: Me > n-Bu, Me > Ph, and cyclohexyl > Me.

188 mbident RNH[N(O)NO](-) ion (R = isopropyl or cyclohexyl) has been shown to occur at the terminal oxyg

189 sed on CO(2), the selective decomposition of cyclohexyl hydroperoxide to cyclohexanone, and the asymm

190 2) the hydroxyl group of the ethanol and the cyclohexyl hydroxyl group of HHC, (3) the alkyl tail and

191 mposition and fragmentation pathways of four cyclohexyl hydroxylation metabolites and one ethylhydrox

192 se adduct of B(2)pin(2) and the NHC (1,3-bis(cyclohexyl)imidazol-2-ylidene), which was proposed to ac

193 site is 75-fold greater than that for the 5-cyclohexyl-indole derivative.

194 ve alkylations of arylmagnesium halides with cyclohexyl iodides at ambient temperature has been devel

195 dent SFG experiments that dehydrogenation of cyclohexyl is a rate-limiting step in the cyclohexane ca

196 )Ti)(2)(mu-eta(1),eta(1)-CyNCNCy) (10) (Cy = cyclohexyl) is reported.

197 h the catecholate dianion in the presence of cyclohexyl isocyanide results in the formation of [(o-(P

198 ium dimer [(H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce various novel nitrogen

199 tion and detection of 1,6-dichlorohexane and cyclohexyl isothiocyanate as part of the diesel fuel ana

200 ido ketones with NaH afforded the beta-amino cyclohexyl ketones in excellent yields and diastereosele

201 h an IC50 = 0.54 mm and PAC, a disubstituted cyclohexyl Kv channel inhibitor, inhibited with an IC50

202 sublethal nitrosourea ([1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea]; CCNU) concentrations.

203 h is driven by dispersive forces between the cyclohexyl ligands and the formation of short and strong

204 y by replacing the phenyl linker of 1 with a cyclohexyl linker and by replacing the 4-benzylpiperidin

205 ron length of venule (16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S- methyl-LXA4-Me, respecti

206 (LXA4) analogs (i.e., 16-phenoxy-LXA4-Me, 15-cyclohexyl-LXA4-Me, and 15-R/S-methyl-LXA4-Me) were stud

207 n in this series, two analogues ([N(epsilon)-cyclohexyl-Lys(8)]degarelix, IC(50) = 1.50 nM) (23) and

208 4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229), from the c

209 cetone, t-butyl methyl ketone, acetophenone, cyclohexyl methyl ketone, and cyclohexyl phenyl ketone.

210 The 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide scaffold was studied as a te

211 yl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl) cyclohexyl]methyl]-1H-indole-3-propanamide] and PD176252

212 d PD176252 [(S)-N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-a-methyl-a-[[-(4-nitrophenyl )amino]c

213 4,264 (N-[(1R)-2-[[[(1S*,3R*)-3-(aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylm ethyl)-2-oxoe

214 N-alkyl side chain and the 2-position of the cyclohexyl moiety afford a 60,000-fold range of rates.

215 +)(CH(3))(3) chain in the 2-position and the cyclohexyl moiety in the 6-position, showed pK(i) values

216 final reduction step in the formation of the cyclohexyl moiety of ansatrienin from shikimic acid.

217 e decalin locks the key selectivity-inducing cyclohexyl moiety of the ligand in a conformation typica

218 appending an (S)-carboxyl group beta to the cyclohexyl moiety provided the less potent tripeptide in

219 spartate was subsequently labeled with the N-cyclohexyl-N'-(4-(dimethylamino)naphthyl)carbodiimide (N

220 he structure of the human sEH complex with N-cyclohexyl-N'-(iodophenyl)urea (CIU) has been determined

221 cadmium doping into the [Au23(SR)16](-) (R = cyclohexyl) nanocluster, in which two neighboring surfac

222 Two bifunctional alpha-phenyl-N-cyclohexyl nitrones were synthesized with the expectatio

223 In addition, particular benzyl and cyclohexyl odorants evoked activity in dorsal modules pr

224 R)N](3-) were prepared by addition of either cyclohexyl or isobutyronitrile to the base free dihafnoc

225 Four different P(R)2N(R')2 ligands with cyclohexyl or phenyl substituents on phosphorus and benz

226 n the present study, galactopyranosides with cyclohexyl or phenyl substitutions, both in alpha and be

227 eptor affinity; in particular, the choice of cyclohexyl- or arylureas led to substantial improvements

228 moiety at the 4-position with variations of cyclohexyl- or phenyl-containing fragments to reduce rot

229 rifluoromethoxy phenyl]amino]carbonyl]-amino]cyclohexyl]oxy]-benzoic acid (TUCB).

230 to hydrolyze the RP-enantiomer of O-methyl O-cyclohexyl p-nitrophenyl thiophosphate with net inversio

231 l-p-phenylenediamine (DPPD), and N-phenyl-N'-cyclohexyl-p-phenylenediamine (CPPD)] and evaluated the

232 ethylheptyl)-2-(5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)phenol (CP55,940) robustly internalized CB(2)

233 g shows that intramolecular rearrangement of cyclohexyl phenyl ether does not significantly contribut

234 acetophenone, cyclohexyl methyl ketone, and cyclohexyl phenyl ketone.

235 f large hydrophobic substituents (isopropyl, cyclohexyl, phenyl, o- or p-nitrophenyl) in beta anomeri

236 R-CF=CF-CF3 (2a, R = cyclopentyl and 2b, R = cyclohexyl), prepared in high yield in two steps from he

237 stly to cycloalkane-derived structures, with cyclohexyl proving to be particularly promising.

238 A series of [4-[2(4-arylpiperazin-1-yl)alkyl]cyclohexyl]pyrimidin-2-ylamine s was prepared and found

239 luminescence of HBC for both a good solvent, cyclohexyl pyrrolidone (CHP), and a poor solvent, tetrah

240 ns of individual molecules in four solvents: cyclohexyl pyrrolidone, 1-chloronaphthalene, 1-bromonaph

241 eCOH (R(F6)OH), react with W(NR)(2)Cy(2) (Cy=Cyclohexyl; R=2,6-diisopropylphenyl or 1-adamantyl) in C

242 A substituent on the 3-position of the cyclohexyl radical enables ring-cleavage of the cyclohex

243 ilizing substituent on the 2-position of the cyclohexyl radical stabilizes the final cyclopentylmethy

244 The rearrangement of a substituted cyclohexyl radical to a cyclopentylmethyl radical on the

245 lohexyl radical enables ring-cleavage of the cyclohexyl radical, while a radical stabilizing substitu

246 are present at the 2- and 3-positions of the cyclohexyl radical.

247 Trapping of cyclohexyl radicals by quinoxaline is inefficient except

248 Pd(PCy(3))(2) (Cy = cyclohexyl) reacts with As(7)(3-) in en/tol solvent mixt

249 ly discovered thiophenes as highly efficient cyclohexyl replacement moieties that retain the strong s

250 including the widely used SAFit2, contain a cyclohexyl residue as a key motif for enabling selectivi

251 f the phenolic ring (A ring) relative to the cyclohexyl ring (C ring), and the orientation of the hyd

252 hed by replacement of the 2-aryl ring with a cyclohexyl ring and subsequent elaboration of the 4-posi

253 esting that the stabilization comes from the cyclohexyl ring and/or the electronic effect of the carb

254 It was determined that the presence of the cyclohexyl ring did not affect either the reduction or o

255 ctures, displaying alkyl groups bound to the cyclohexyl ring in equatorial position, and other quite

256 We find that alkoxy bond scission of the cyclohexyl ring likely leads to efficient HOM formation,

257 e ring as well as methyl substitution on the cyclohexyl ring significantly improved metabolic stabili

258 revealed that attaching alkyl groups to the cyclohexyl ring significantly improved Mtb activity but

259 Although the cyclohexyl ring structure leads to three nearly degenera

260 with either a heterocyclic ring system or a cyclohexyl ring substituted with polar groups provided p

261 this ligand was systematically replaced by a cyclohexyl ring system, which more closely resembles the

262 re synthesized with the expectation that the cyclohexyl ring will impart lipophilicity to the molecul

263 sequent elaboration of the 4-position of the cyclohexyl ring with a variety of hydrophilic functional

264 logues incorporating fluorine atoms onto the cyclohexyl ring(s) provided a range of different fluorop

265 nts of TSA.1 are almost perpendicular to the cyclohexyl ring, leading to decreased orbital overlap an

266 may contain up to eight cyclopentyl and one cyclohexyl ring, where higher degrees of cyclization are

267 Ph-OH pointing toward the alpha-face of the cyclohexyl ring, while for 4, there is an increased pref

268 the CF(3) groups are on the same face of the cyclohexyl ring.

269 iated by a Michael reaction to introduce the cyclohexyl ring.

270 h the aromatic ring and points away from the cyclohexyl ring; ii) the dimethylheptyl chain adopts one

271 arbonyl groups and the hydrogen atoms of the cyclohexyl rings and C=O---C=O intimate dipole interacti

272 Historically, the number of cyclopentyl and cyclohexyl rings in the glycerol dibiphytanyl glycerol t

273 yl (DMH) side chain, the conformation of the cyclohexyl rings, the orientation of the phenolic ring (

274 s, each with a nonpolar domain formed by six cyclohexyl side chains arranged along one side of the 14

275 hydrophobic interaction generated by the six cyclohexyl side chains.

276 Unsubstituted 5-amidine groups and a cyclohexyl spacer were the crucial determinants of trypa

277 ydroxymethyl, phenyl, carboxyl, pyridyl, and cyclohexyl substituent groups alpha to the nitrogen atom

278 wo electron-rich ortho-biphenyl groups and a cyclohexyl substituent.

279 ic interactions with the "C-H"-groups of the cyclohexyl substituents result in an unusual low-spin sq

280 alized with p-nitrobenzyl, methyl, and trans-cyclohexyl substituents were studied.

281 erant to the stereochemistry of the attached cyclohexyl substituents.

282 The heteroleptic compounds feature a cyclohexyl-substituted beta-diketiminate (CyNacNac(Me))

283 yNacNac(Me))(CN-Ar), where CyNacNac(Me) is a cyclohexyl-substituted beta-diketiminate and CN-Ar is an

284 The X-ray structure obtained for meso-cyclohexyl-substituted calix[6]phyrin revealed that the

285 We tested cyclohexyl-substituted isochroman, carbocyclic, and chro

286 The cyclohexyl-substituted system shows the largest Z-prefer

287 ly fails to react (too bulky), that with R = cyclohexyl suffers a (controllable) tendency to abstract

288 In the cyclohexyl system, a small amount of a cyclopropane deri

289 mpregnated with bis-nitroxide biradical (bis-cyclohexyl-TEMPO-bisketal, bCTbK) solutions of organic s

290 EIE (K(H)/K(D)) for transfer of cyclopentyl, cyclohexyl, tetrahydrofuranyl and tetrahydropyranyl cati

291 The formation of a spiro-cyclohexyl-thiadiazoline system (sCT) offered the rare o

292 ether with the observation that a simplified cyclohexyl thioglycoside mycothiol analogue is a good su

293 The content of omega-cyclohexyl tridecanoic acid varied from 0.0% to 0.15% of

294 xanol forms initially but then esterifies to cyclohexyl trifluoroacetate.

295 Pd(PCy(3))(2) (4) (1-Ad = 1-adamantyl, Cy = cyclohexyl) was studied to determine the effect of steri

296 larger, branched beta-alkyl esters, such as cyclohexyl, were less potent.

297 d {Li(C(6)H(2)-2,4,6-Cy(3)).OEt(2)}(2) (Cy = cyclohexyl) with SnCl(2) afforded the distannene {Sn(C(6

298 Alkyl Grignard reagents (Et, (n)Bu, (i)Pr, cyclohexyl), with the exception of (t)BuMgCl, undergo ex

299 Alpha-ethyl and alpha-cyclohexyl (Z)-trisubstituted allylic alcohols can now b

300 [eta5-C5H2((S)-CHMeCMe3)]]ZrCl2, (S)-7 (Cy = cyclohexyl), zirconocene dichlorides that have an enanti