ライフサイエンスコーパス: cyclopentane

1 f PNA+DNA duplexes by approximately +5 C per cyclopentane.

2 ophilic alpha-carbon to form the substituted cyclopentane.

3 ty (by 0.07-0.25 Log P units) as compared to cyclopentane.

4 oped for the synthesis of highly substituted cyclopentanes.

5 onalized pyrrolidines, tetrahydrofurans, and cyclopentanes.

6 ective synthesis of trisubstituted borylated cyclopentanes.

7 ctions and ring-opening reactions to provide cyclopentanes.

8 target HIV RNA compared with PNA without the cyclopentanes.

9 ffords a diverse range of beta-lactone fused cyclopentanes.

10 d in situ from Cu(OTf)(2) and (4S,4'S)-2,2'-(cyclopentane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole),

11 EMM-59 was synthesized using 2,2-(cyclopentane-1,1-diyl)bis(N,N-diethyl-N-methylethan-1-am

12 yl}-N-methyl-N'-[4-(trifluor omethoxy)benzyl]cyclopentane-1,2-dicarboxamide (CDA54), a peripherally a

13 non-subtype selective mGluR agonist 1-amino-cyclopentane-1,3-dicarboxylic acid (tACPD).

14 two-carbon ring expansion of enol ethers of cyclopentane-1,3-dion.

15 mation, we synthesized analogues of 1 with a cyclopentane-1,3-diyl linker.

16 nd the fluorines at C1 and C3 in the singlet cyclopentane-1,3-diyl transition structure (TS) contribu

17 ven the catenation of two open-shell singlet cyclopentane-1,3-diyls is achieved.

18 rase inactivator (1R,3S,4S)-3-amino-4-fluoro cyclopentane-1-carboxylic acid (1), in this work, we rat

19 tivator (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid (5), we rationally design

20 (1S,3S,4R)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]28) have been pre

21 (1S,3R,4S)-1-amino-3-fluoro-4-(fluoro-(18)F)cyclopentane-1-carboxylic acid ([(18)F]9) and (1S,3S,4R)

22 (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride (1) was fou

23 atalytic route to the (1S,2R)-2-(aminomethyl)cyclopentane-1-carboxylic acid monomer precursor, which

24 n the peroxisome to 3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0), which subsequent

25 idene cyclopentanes 1b-9b and monoalkylidene cyclopentanes 10b-18b, respectively, in good to excellen

26 trans-1-(diphenylmethyl)-2-(1-methylethenyl)cyclopentane (11).

27 )4] (HEB = eta(6)-hexaethylbenzene; alkane = cyclopentane (16) or pentane (17-19); OR(f) = perfluoro-

28 carbocyclization to afford 1,2-dialkylidene cyclopentanes 1b-9b and monoalkylidene cyclopentanes 10b

29 The photoreactions in cyclopentane, 2-methyl-2-propanol, and the gas phase occ

30 ethoxy-3-methylene-4-(triethylsilylmethylene)cyclopentane (3) in 82% isolated yield with 26:1 Z:E sel

31 )(3)N)U(IV)}(2)(mu-eta(2):eta(2)-1,2-(CH)(2)-cyclopentane)] (3).

32 Sequential addition of cyclopentanes allows the Tm of PNA + DNA duplexes to be

33 we synthesized a series of multisubstituted cyclopentane amide derivatives.

34 The anti cyclopentane analog 29b, was a low-micromolar inhibitor

35 KC inhibitor in the series, anti-substituted cyclopentane analog 29b.

36 ery, as well as accommodating guests such as cyclopentane and cyclohexane in its internal cavity (red

37 molecular radical cyclization pathway, where cyclopentane and cyclohexane repeat units are likely for

38 ctivities were observed for the C-H bonds of cyclopentane and cyclohexane, while the tertiary C-H bon

39 rd reaction consist of chiral derivatives of cyclopentane and cyclopentene and a chiral carbocyclic p

40 CH2CH2NH2, ribose ring replacement by chiral cyclopentane and cyclopentene derivatives, and phosphate

41 terio- and 1,1,1-trideuterio-2-iodooctane in cyclopentane and methanol was also studied.

42 ted through the synthesis of polysubstituted cyclopentane and piperidine derivatives.

43 m in one pot, simultaneously forming two new cyclopentane and pyrano rings by double cyclization reac

44 rcaptosulfide functionality attached to both cyclopentane and pyrrolidine frameworks demonstrated tha

45 allowing for the synthesis of functionalized cyclopentanes and bicyclic cyclopentane-based structures

46 asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes is described.

47 odology uniquely provides beta-lactone-fused cyclopentanes and cyclohexanes readied for further trans

48 ized acyclic products or densely substituted cyclopentanes and pyrrolidines in high yields and regios

49 as the primary source of VOCs, with pentane, cyclopentane, and cyclohexane being the dominant species

50 e dissociative chemisorption of cyclobutane, cyclopentane, and cyclohexane occurs via two different r

51 nd zeta-) or cyclic structures (cyclobutane, cyclopentane, and cyclohexane) to improve tRNA charging.

52 For liquid methane, ethane, cyclopentane, and cyclohexene, models without partial ch

53 te esters containing chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with high to exce

54 ositions, including trans-cyclobutane, trans-cyclopentane, and trans-five-membered cyclic acetals.

55 n chair and twist conformations in colloidal cyclopentane, and we elucidate the interplay of bond ben

56 Overall, this approach to cyclopentane annulation complements the related metal-ca

57 ese are the first examples of ring-expanding cyclopentane annulations that directly introduce a carbo

58 On the other hand, g(H) values in the R,R-cyclopentane are considerably larger than those in R,R-d

59 ilylation to form silylated 1,2-dialkylidene cyclopentanes as mixtures of regioisomers.

60 efficient formation of diversely substituted cyclopentanes as well as the construction of complex bic

61 at colloidal alkanes, specifically colloidal cyclopentane, assembled from tetrameric patchy particles

62 change at positions s120/s145, 6.4%), and d-cyclopentane-associated pol-gene mutations (2.4%).

63 niaquinoids bearing a carbon function on the cyclopentane B ring; it is also applicable to the synthe

64 eaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected B-amino acid ligand.

65 of free carboxylic acids enabled by a novel cyclopentane-based mono-N-protected beta-amino acid liga

66 of functionalized cyclopentanes and bicyclic cyclopentane-based structures in moderate to high yields

67 ve desymmetrization process to access chiral cyclopentane bearing multiple stereocenters with excelle

68 hod allows for the formation of exomethylene cyclopentanes bearing a quaternary center substituted by

69 is transformation generates tetrasubstituted cyclopentanes bearing three contiguous stereocenters in

70 ing (1R,2S)-cyclobutane (betaCbu) or (1R,2S)-cyclopentane (betaCpe) beta-amino acids, which display e

71 em Suzuki reaction-lactonization to join the cyclopentane building block with the aromatic moiety and

72 roketene on a readily prepared exo-methylene cyclopentane building block.

73 side chain or carbonyl functionality at the cyclopentane C2 position.

74 Furthermore, the obtained chiral cyclopentanes can be readily functionalized to provide v

75 yl)-2-azabicyclo[3.3.1]non -7-yl-(1-phenyl-1-cyclopentane)carboxamide [(+)-KF4, (+)-4], showed a K(e)

76 yl)-2-azabicyclo[3.3.1]non -7-yl-(1-phenyl-1-cyclopentane)carboxamide [(+)-KF4, (+)-5] as a novel che

77 d; (Cpc1)4OT in which Pro1 was replaced with cyclopentane carboxylate; a derivative [Met(O)45]4OT in

78 intramolecular cyclization of trisubstitued cyclopentane carboxylates bearing a leaving group (at th

79 the gamma-amino acid (1R,2R)-2-aminomethyl-1-cyclopentane carboxylic acid (AMCP) and an evaluation of

80 unreported pseudodiproline dimers in which a cyclopentane carboxylic acid is linked to a pyrrolidine

81 iguration of the vicinally substituted trans-cyclopentane carboxylic acid unit (Cyp).

82 For cyclopentane carboxylic acids, reluctant to aromatizatio

83 lkylation of enals leading to functionalized cyclopentanes catalyzed by O-trimethylsilyldiphenylproli

84 A trisubstituted cyclopentane chiron has been prepared by dynamic kinetic

85 as been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramol

86 Functionalized cyclopentanes containing a quaternary carbon center are

87 th (E)-1,3-disubstituted 2-butenols generate cyclopentanes, containing four new stereogenic centres w

88 lytic hydrogenation, were transformed to new cyclopentane-containing pyrazolopyrimidines 24 and 28, a

89 used to achievethe efficient formation of a cyclopentane core and bicyclic lactone bearing two quate

90 The resulting cyclopentane core and bicyclic lactones were elaborated

91 products are known, more often than not, the cyclopentane core is assembled in a stepwise manner beca

92 zarov cyclization to construct the congested cyclopentane core revealed an unanticipated electronic b

93 tion between the C- and N-termini around the cyclopentane core.

94 es the three contiguous stereocenters of the cyclopentane core.

95 only nine nucleobases and an equal number of cyclopentanes, cpPNA-9 binds to complementary DNA with a

96 complexes, strained cycloalkanes, including cyclopentane, cycloheptane, and cyclooctane, undergo C-H

97 g furanose-fused oxepane, thiepane, azepane, cyclopentane, cycloheptane, tetrahydrofuran, and pyranos

98 Similarly, cyclopentane, cyclohexane, and cycloheptane rings were c

99 h mechanisms predicted similar lifetimes for cyclopentane, cyclohexane, and, to a lesser extent, cycl

100 ings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus

101 an m-phenylene ring replacing the steroidal cyclopentane D-ring.

102 yclopentadienyl), with samples of [CpRe(CO)2(cyclopentane)] decaying significantly more rapidly than

103 potent and selective (>50,000-fold vs CatK) cyclopentane derivative 22 by exploiting specific ligand

104 to various 1,5-diketones and functionalized cyclopentane derivative in good to excellent yields.

105 sis of diversified aminated cyclopentene and cyclopentane derivatives being relevant for drug synthes

106 e the proline ester based auxiliary from the cyclopentane derivatives by gamma-lactone formation unde

107 mines with activated cyclopropane to deliver cyclopentane derivatives have shown the value of this me

108 merically pure, tetra- and penta-substituted cyclopentane derivatives in which all of the substituent

109 ring an internal alkyne furnished the chiral cyclopentane derivatives with excellent enantiomeric exc

110 as flattened analogues of the corresponding cyclopentane derivatives with fixed envelope conformatio

111 o appropriately situated side chains to form cyclopentane derivatives.

112 oach to a diverse range of saturated bridged cyclopentane derivatives.

113 Silylated cyclopentanes derived from HSiMe(2)OSiMe(3) were oxidize

114 Silylated cyclopentanes derived from HSiMe(2)OSiPh(2)t-Bu were oxi

115 ious molecules: S,S-cyclopentane diacid, R,R-cyclopentane diacid, and succinic acid.

116 ptides were linked to various molecules: S,S-cyclopentane diacid, R,R-cyclopentane diacid, and succin

117 that were oxidatively ring-opened to afford cyclopentane dialdehydes.

118 PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several

119 acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases bindi

120 he general mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were closely corre

121 d-spectrum mGluR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid [(1S,3R)-ACPD], group I/I

122 ions to form cyclopropanes, cyclobutanes and cyclopentanes en route to structurally intriguing carboc

123 with the recently developed FA derivative FA-cyclopentane (FA-CP) to 2.0 angstrom resolution.

124 latter event may provide a driving force for cyclopentane formation.

125 the formation of substituted stereo-defined cyclopentanes from Ph* methyl ketone and cyclopropyl alc

126 ing reaction to form substituted aminomethyl-cyclopentanes from secondary amines, cyclopropyl aldehyd

127 leading to the enantioselective synthesis of cyclopentane-fused beta-lactones is presented.

128 n cyclization-pinacol reactions that provide cyclopentane-fused cycloalkanone products are described.

129 For the surface PNA probe, four cyclopentane groups were incorporated to promote stronge

130 Replacing the S,S-dioxolane by an S,S-cyclopentane had no effects on the g(H)-[H(+)] relations

131 f cyclopentanes, including gem-disubstituted cyclopentanes having substitution on three contiguous ca

132 ired cycloisomerization pathway to methylene cyclopentanes; however, double bond isomerization, elimi

133 The replacement of the furanose ring by a cyclopentane in nucleosides generates a group of analogu

134 ctive intermediates generates functionalised cyclopentanes in generally good yields and excellent dia

135 (3))(2)] to form the corresponding silylated cyclopentanes in good yield with high diastereoselectivi

136 -protected norbornylamine and to substituted cyclopentanes in nearly enantiopure form.

137 The overall scheme gave a diverse array of cyclopentanes, including gem-disubstituted cyclopentanes

138 e synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-hetero

139 the methylpyrroline ring of pyrrolysine with cyclopentane indicated that solely hydrophobic interacti

140 Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increase

141 carbon cyclize to give 1,2-trans-substituted cyclopentanes is experimentally disproved by study of th

142 ethylene group bound to the metal within the cyclopentane ligand in 16 was observed at 212 K, with th

143 ture of the cpPNA-9-DNA duplex revealed that cyclopentanes likely induce a right-handed helix in the

144 tingly, g(H)-[H(+)] relationships in the R,R-cyclopentane-linked gA channel are quite similar to thos

145 dicinal chemistry effort to develop novel P2 cyclopentane macrocyclic inhibitors guided by HCV NS3 pr

146 ic and resolved 2-iodooctane was examined in cyclopentane, methanol, and 2-methyl-2-propanol, media w

147 nd PGD(2) direct their opposite faces of the cyclopentane moieties toward the nicotinamide ring of th

148 ts the QueG active site places the substrate cyclopentane moiety in close proximity of the cobalt.

149 tein or the bound NADPH, indicating that the cyclopentane moiety is movable in the active site.

150 n H-bonding with protein residues, while the cyclopentane moiety is surrounded by water molecules and

151 A-CP binds in an identical position, but its cyclopentane moiety provides additional contacts to EF-G

152 Although a number of biologically relevant cyclopentane natural products are known, more often than

153 Stereoselective synthesis of a cyclopentane nucleus by convergent annulation constitute

154 (001) surface, dissociative chemisorption of cyclopentane occurs via initial C-C bond cleavage over t

155 g-opening of the cyclopropane affords either cyclopentane or cyclohexane derivatives in which the C6F

156 or N(2) gives 2-methyl-1-silylmethylidene-2-cyclopentane or its heteroatom congener in excellent yie

157 sponding 2-formylmethyl-1-silylmethylidene-2-cyclopentane or its heteroatom congener with excellent s

158 ates with alkynes were utilized to construct cyclopentanes or dehydro-delta-lactams.

159 is highly effective using cyclohexene oxide, cyclopentane oxide, substituted cyclohexene oxide, and b

160 Moreover, the cyclopentane portion of the fluorophore structure provid

161 These proline-cyclopentane (Pro-Cyp) dimers have interesting structura

162 itional fusion of a cyclopropane ring to the cyclopentane produces a bicyclo[3.1.0]hexane system that

163 acid alkylidenes to give highly substituted cyclopentane products.

164 nder silylene-mediated conditions to provide cyclopentane products.

165 natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol.

166 tes, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]

167 erating valuable di- and trifluoromethylated cyclopentanes, pyrrolidines and tetrahydrofurans.

168 ives in which all of the substituents on the cyclopentane ring are syn to one another.

169 eocenters at the other four positions of the cyclopentane ring can also be introduced with good stere

170 c acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction

171 This route efficiently forms the cyclopentane ring from simple and easily accessible star

172 the nucleobase is able to lock the embedded cyclopentane ring into conformations that mimic the typi

173 ssified into two types: methods in which the cyclopentane ring is formed by ring closing reactions (C

174 The cyclopentane ring of PGD(2) and the phenyl ring of rutin

175 ential neuraminidase inhibitors in which the cyclopentane ring served as a scaffold for substituents

176 ation of lithocholic acid at C(3) and at the cyclopentane ring side chain.

177 The racemic cyclohexane-for-cyclopentane ring substitution analogue of the potent pr

178 d acylphloroglucinols with a pendant complex cyclopentane ring that exhibit activity against several

179 roxides with the two alkyl chains syn on the cyclopentane ring were formed preferentially to those wi

180 f an alpha-diazo-beta-ketoester to build the cyclopentane ring, followed by reduction of the enol tri

181 ipulation of individual positions around the cyclopentane ring, namely highly diastereoselective inst

182 iguration of the substituents in the forming cyclopentane ring.

183 well as a flexible analogue (7) built with a cyclopentane ring.

184 6)) to the ratio of GDGTs with two and three cyclopentane rings (GDGT-2/GDGT-3).

185 he dibiphytanyl chain due to the presence of cyclopentane rings and branched methyl groups and due to

186 are most likely dominated by cyclohexane and cyclopentane rings and not larger cycloalkanes.

187 al membrane-spanning lipids with up to eight cyclopentane rings and/or one cyclohexane ring.

188 unsaturated acylpyrroles, giving the product cyclopentane rings bearing three stereocenters in high e

189 c compounds possessing highly functionalized cyclopentane rings has been developed employing soft ket

190 attributed to the decrease in the number of cyclopentane rings in PLFE at the lower growth temperatu

191 Incorporation of cyclopentane rings into the tetraether lipids did not af

192 e archaeal membrane-spanning lipids with 0-8 cyclopentane rings on the biphytanyl chains.

193 rol tetraethers containing one, two or three cyclopentane rings were enriched at the base of the SMTZ

194 Changing the central cyclopentane scaffold to the analogous pyrrolidine deriv

195 led to the discovery of a 1,3-disubstituted cyclopentane scaffold with enhanced hCCR2 receptor bindi

196 One of these molecules has an unusual cyclopentane structure similar to those recently reporte

197 ntrolled construction of densely substituted cyclopentane structures not synthetically accessible usi

198 Because of the frequent occurrence of cyclopentane subunits in bioactive compounds, the develo

199 1,3-diaxial conformers are more favored for cyclopentane than for cyclohexane rings.

200 With meso-2,2'-bis(difluoromethylene)cyclopentane, this destabilization is sufficient to favo

201 ovides efficient and direct access to chiral cyclopentanes through the generation of two stereocenter

202 2-methylpropane, 2-butyne, acetone, pentane, cyclopentane, trifluoroethane, fluoromethane, dimethyl e

203 polymer contains the expected methylene-1,3-cyclopentane units as well as the unexpected 3-vinyl tet

204 w simple method to access highly substituted cyclopentanes via Lewis acid-initiated formal [3 + 2]-cy

205 trast, no thermal reaction between ozone and cyclopentane was observed.

206 ester substituted indanes, cyclohexanes, and cyclopentanes were prepared in good yields with excellen

207 Spirooxindole-fused cyclopentanes were produced in excellent isolated yields

208 Spirooxindole-fused cyclopentanes were produced in moderate-to-good isolated

209 Cyclopropanes, cyclobutanes and cyclopentanes within such carbocycles can be synthesized