ライフサイエンスコーパス: cyclophilin

1 n in complex with the most abundant cellular cyclophilin.

2 ER oxidative pathway that is modulated by ER cyclophilins.

3 hrin A inhibit the enzymatic activity of the cyclophilins.

4 disulfide/thiol patterns of the recombinant cyclophilin 1 monomer (rTvCyP1 mono) from the human path

5 describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-respo

6 Here we show that cyclophilin 40 (CyP40), a PPIase, dissolves tau amyloids

7 d in a pi-stacking interaction with Arg55 of cyclophilin A (Cyp A), and the m-Tyr residue was displac

8 tures of apo-CA hexamers and in complex with cyclophilin A (CypA) at near-atomic resolutions.

9 ity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its c

10 Cyclophilin A (CypA) has interacted with the CA of lenti

11 PO3, addition of the CA-binding host protein cyclophilin A (CypA) inhibited HIV-1 uncoating and reduc

12 lex, the maedi-visna virus (MVV) Vif hijacks cyclophilin A (CypA) instead.

13 The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 c

14 interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replicat

15 that the prolyl cis-trans isomerase (PPIase) cyclophilin A (CypA) is hijacked by Listeria at membrane

16 Recent studies showed that cyclophilin A (CypA) promotes NF-kappaB/p65 nuclear tran

17 Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity t

18 Herein, we identify a novel Cyclophilin A (CypA) small molecule inhibitor (HL001) th

19 CA interactions with both CPSF6 and cyclophilin A (CypA) were essential for the unique dose-

20 e, using chemical inhibition or silencing of cyclophilin A (CypA), as well as CA mutant viruses, we i

21 on of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of re

22 rly part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation speci

23 ice lacking the essential cellular co-factor cyclophilin A (CypA), HCV RNA replication is markedly di

24 olecular dynamics simulations to study human cyclophilin A (CypA), in order to understand the role of

25 denylation specificity factor 6 (CPSF6), and cyclophilin A (CypA), indicating that the observed loss

26 on specific factor 6 (CPSF6), as well as the cyclophilin A (CypA)-binding loop mutation P90A, all inc

27 5A, which encompasses residues implicated in cyclophilin A (CypA)-dependent HCV RNA replication.

28 that functions by targeting a host protein, cyclophilin A (CypA).

29 ency virus type 1 (HIV-1) CA binding protein cyclophilin A (CypA).

30 ng Fv1NtD fused to the HIV-1 binding protein Cyclophilin A (CypA).

31 us (HCV) requires host cell factors, such as cyclophilin A (CypA).

32 red with wild-type controls through secreted cyclophilin A (CypA).

33 eta1 stimulation via robust up-regulation of cyclophilin A (CypA).

34 nd orthologs of essential host factors, like cyclophilin A (CypA).

35 pendent upon CA interacting with host factor cyclophilin A (CypA).

36 wn, including kallikrein-7 (KLK7; 2.2-fold), cyclophilin A (PPIA; 0.9-fold), and cofilin-1 (CFL1, 1.3

37 variants, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), are attractive candidates owing to

38 orthologs, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restricto

39 ether, these data provide evidence that both cyclophilin A and B interact with CYDV-RPV, and these in

40 equired for proper interaction with the host cyclophilin A and influences its peptidyl-prolyl cis/tra

41 e cis-bound and trans-bound conformations of cyclophilin A and its substrate as the enzymatic reactio

42 ive HIV-1 capsid mutants P90A (defective for cyclophilin A and Nup358 recruitment) and N74D (defectiv

43 nsity collected from crystals of the enzymes cyclophilin A and trypsin.

44 and its interaction with the human chaperone cyclophilin A are both targets for highly potent and pro

45 he inner face of the viral matrix and at the Cyclophilin A binding loop of the capsid.

46 , including the N-terminal beta-hairpin, the cyclophilin A binding loop, the inter-domain linker, seg

47 but mutants that recapitulate the effect of Cyclophilin A binding on capsid conformation and dynamic

48 Cyclophilin A contributes to aortopathy induced by postn

49 We also found that purified cyclophilin A destabilizes in vitro-assembled HIV-1 CA-N

50 We show that cyclophilin A displays rich dynamics following a tempera

51 Our results suggest that TNPO3 and cyclophilin A facilitate HIV-1 infection by coordinating

52 In this study, a human cyclophilin A homologue, TvCyclophilin 1 (TvCyP1), was i

53 fort, evidence of developmental functions of cyclophilin A in non-plant systems has remained obscure.

54 In addition, cyclophilin A increased Crk SH3 domain-binding guanine-n

55 hat indirectly targets NS5A by blocking NS5A/cyclophilin A interaction.

56 ye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by

57 Cyclophilin A is a conserved peptidyl-prolyl cis-trans i

58 Cyclophilin A is a tractable model system to study using

59 the more expanded and unstructured denatured cyclophilin A is not encapsulated but is expelled into s

60 Cyclophilin A localizes within the F-actin of these stru

61 Catalysis of proline isomerization by cyclophilin A lowers the energy barrier for alpha-synucl

62 Mutations in a tomato (Solanum lycopersicum) cyclophilin A ortholog, DIAGEOTROPICA (DGT), have been s

63 n binding interaction of Cyclosporine A with cyclophilin A protein in a yeast cell lysate is successf

64 The recruitment of cyclophilin A to GTP-bound Ras blocks its interaction wi

65 sing disparity is the weaker interactions of cyclophilin A with a transiently formed GroEL-GroES comp

66 We have obtained HDX data for the complex of cyclophilin A with the immunosuppressant cyclosporin A.

67 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously

68 nal domains on TRIM5alpha (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids.

69 APDH and LDH) but not others (e.g. Hsp90 and cyclophilin A).

70 sets, the top ranked gene was PPIA, encoding cyclophilin A, a druggable target using cyclosporine.

71 Cyclophilin A, a known ligand of BSG, competitively redu

72 inhibition of HIV infection by SUN2 involves cyclophilin A, a protein that binds the HIV capsid and d

73 EMENT We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-i

74 Cyclophilin A, also known as peptidylprolyl cis-/trans-i

75 not CrkI, associates with the immunophilins, cyclophilin A, and 12-kDa FK506-binding protein, in rest

76 , in contrast to HCV, HAV does not depend on cyclophilin A, but rather on adenosine-triphosphate-bind

77 scattering measurements on a dynamic enzyme, cyclophilin A, demonstrating that these experiments are

78 ent conformational properties, rhodanese and cyclophilin A, during binding and encapsulation by GroEL

79 We show here that cyclophilin A, one of the most common PPIases, provides

80 Other host factors, such as cyclophilin A, stabilize the HIV-1 capsid and are requir

81 as well as literature values for uncomplexed cyclophilin A, to theoretical predictions using a combin

82 within a nuclear localization signal in the cyclophilin A-binding loop, is critical for engaging the

83 regions, including the NTD beta-hairpin, the cyclophilin A-binding loop, residues in the hexamer cent

84 with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in

85 particularly activation of a proinflammatory cyclophilin A-mediated pathway in brain vascular pericyt

86 f high PF74 concentrations was attenuated by cyclophilin A.

87 on other isomerases such as Pin4, FKBP12, or cyclophilin A.

88 merization outpowers the holding activity of cyclophilin A.

89 sed immunophilin proteins such as FKBP12 and cyclophilin A.

90 s were found and identified, namely enolase, cyclophilin-A, ribosomal protein L13 and actin-1.

91 independent of cyclophilins, suggesting that cyclophilins act either in parallel to or downstream of

92 These discoveries imply that reduced cyclophilin activity contributes to the development of d

93 Leishmanial cyclophilin also mediates trialysin protection and metab

94 RNA replication was dependent on mouse cyclophilin and phosphatidylinositol-4 kinase III alpha

95 milar to the TPR-containing Cyp40-like Cpr7p cyclophilin and the Ttc4 oncogene-like Cns1 cochaperone,

96 Furthermore, drugs against human cyclophilins and parvulins will be reviewed in their cur

97 ized urea-based small molecule inhibitors of cyclophilins and tested them against CypD using binding

98 e broadly applicable across highly conserved cyclophilins and their Aux/IAA targets.

99 We find that many of these, including cyclophilins and thioredoxins, are substoichiometric RNA

100 ree predicted pathogenicity genes, a MAPK, a cyclophilin, and a calcineurin regulatory subunit.

101 mprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins.

102 Cyclophilins are a family of highly conserved enzymes im

103 Cyclophilins are also chaperones.

104 Cyclophilins are host factors required for hepatitis C v

105 er, little is known about whether hepatocyte cyclophilins are involved in the hepatitis B virus (HBV)

106 Cyclophilins are structurally conserved pan-allergens sh

107 Cyclophilins are ubiquitous proteins found in all domain

108 The cyclophilins are widely expressed enzymes that catalyze

109 (CRTAP), prolyl 3-hydroxylase 1 (P3H1), and cyclophilin B (CYPB) cause types VII-IX osteogenesis imp

110 Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the

111 omplex with cartilage-associated protein and cyclophilin B (CypB).

112 ges in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2)

113 Cyclophilin B and FKBP13 exhibited much lower activity t

114 n the rER, and so far, two of these enzymes, cyclophilin B and FKBP65, have been shown to be involved

115 avage of the minor capsid protein L2 by host cyclophilin B and furin.

116 ational changes, leading to isomerization by cyclophilin B and proprotein convertase-mediated L2 mino

117 B. pseudomallei carries a putative cyclophilin B gene, ppiB, the role of which was investig

118 tive presenilin 1 were observed in brains of cyclophilin B knockout mice.

119 The absence of either cyclophilin B or FKBP65 leads to a recessive form of ost

120 Two cyclophilin B proteins, S28 and S29, were identified pre

121 doplasmic reticulum (ER)-resident chaperone, cyclophilin B, from assisting presenilin 1 to fold prope

122 Contrastingly, knockout of cyclophilin B, reported to participate in invasion and i

123 leavage of the minor capsid protein, L2, and cyclophilin B-mediated separation of L2 and the viral ge

124 during infection at a step downstream of the cyclophilin B-mediated unfolding of L2.

125 ic reticulum (ER) cyclophilin in addition to cyclophilin B.

126 ent that triggered efficient ER depletion of cyclophilins B and C by inducing their secretion to the

127 a cells, we found that combined knockdown of cyclophilins B and C delayed transferrin secretion but s

128 philin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis, and sugges

129 Drosophila NinaA and its mammalian homolog, cyclophilin-B, impair opsin biogenesis and cause osteoge

130 n hydrophobicity of the P4 residue preserves cyclophilin binding and antiviral potency while decreasi

131 We propose that cyclophilin binding provides conformational flexibility

132 isomerases to protein folding and identified cyclophilin C as an endoplasmic reticulum (ER) cyclophil

133 These findings establish cyclophilin C as an ER cyclophilin, demonstrate the nove

134 Because cyclophilins can regulate nuclear gene expression, we ex

135 Cyclophilins catalyze the cis-trans isomerization of xaa

136 The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomeri

137 thermodynamic and kinetic parameters for any cyclophilin-catalyzed W-P isomerization have been report

138 Cyclophilin catalyzes the ubiquitous process "peptidyl-p

139 agment within the primary structure of yeast cyclophilin CPR1 by replacing its homologous sequence re

140 tion of the unfolding of yeast mitochondrial cyclophilin (CPR3) induced by urea.

141 The citrus (Citrus sinensis) cyclophilin CsCyp is a target of the Xanthomonas citri t

142 Cyclophilin (Cyp) allergens are considered pan-allergens

143 tion of binders to different isoforms of the cyclophilin (Cyp) protein family.

144 luated by small interfering RNA knockdown of cyclophilin (CYP)A, CYPC, or CYPD in HepG2215 cells, or

145 Regulated necrosis (RN) may result from cyclophilin (Cyp)D-mediated mitochondrial permeability t

146 Host cyclophilins (Cyps) have been implicated in viral evasio

147 However, this occurs independently of cyclophilin D (cyclosporine A insensitive) rather it is

148 ER-000444793 neither affected cyclophilin D (CypD) enzymatic activity, nor displaced o

149 Cyclophilin D (CypD) is a mitochondrial matrix peptidyl-

150 Cyclophilin D (CypD) is a peptidyl-prolyl isomerase expr

151 The mitochondrial matrix protein cyclophilin D (CypD) is an essential component of the mi

152 Ppif-/-) of the mitochondrial matrix protein cyclophilin D (CypD) prevents perinatal KET-induced incr

153 drial permeability transition pore regulator cyclophilin D (CypD) promotes NGSIS, but not glucose-sti

154 production, while within ATP synthase is the cyclophilin D (CypD) regulated mitochondrial permeabilit

155 ficient for the mitochondrial matrix protein cyclophilin D (CypD) show robust protection from PVI dys

156 Cells deficient in cyclophilin D (CypD), a component of the MPTP, are resis

157 ng mice with a platelet-specific deletion of cyclophilin D (CypD), a mediator of necrosis, we found t

158 inhibition of the mitochondrial MAM protein, cyclophilin D (CypD), altered insulin signaling in mouse

159 mitochondrial permeability transition pore, cyclophilin D (CypD), influenced endothelial metabolism

160 tween ANT3 and the peptidyl-prolyl isomerase cyclophilin D (CypD), mortalin decreased mitochondrial p

161 ion of adenine nucleotide translocase (ANT), cyclophilin D (CypD), or mitochondrial Ca(2+) uniporter

162 The PTP is regulated by matrix cyclophilin D (CyPD), which also binds the lateral stalk

163 mitochondrial single-channel patch clamp and cyclophilin D (CypD)-deficient mice (Ppif (-/-)) with st

164 Here, we report an unexplored role of cyclophilin D (CypD)-dependent mitochondrial permeabilit

165 by which p53 activates the key mPT regulator cyclophilin D (CypD).

166 ochondria inner pore permeability regulator, Cyclophilin D (CypD).

167 that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial

168 r mitochondrial Ca(2+) retention, similar to cyclophilin D (CypD, PPIF) knockdown with sustained Delt

169 The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of t

170 Cyclophilin D (PPIF or CypD) is a peptidyl-prolyl cis-tr

171 revents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mit

172 unique mechanism involving the regulation of cyclophilin D activity, a component of the mitochondrial

173 Both pathways were mediated by cyclophilin D and led to mitochondrial depolarization an

174 rial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS.

175 with megakaryocyte-directed deletion of the cyclophilin D gene.

176 by Mg(2+)/ADP; (ii) that expression of human cyclophilin D in mitochondria of Drosophila S2R(+) cells

177 peripheral stalk, provides the site at which cyclophilin D interacts.

178 An X-ray structure of 33 bound to rat cyclophilin D is reported.

179 hibitor cyclosporine A, sanglifehrin, and in cyclophilin D knockout mice.

180 Targeted deletion of the cyclophilin D subunit of the mPT complex abrogated the e

181 he pathway involving enhanced interaction of cyclophilin D with ATP synthase mediates L-arginine-indu

182 xygen species (ROS) and the participation of cyclophilin D, a component of the mitochondrial permeabi

183 m(s) by eliminating ubiquitous expression of cyclophilin D, a critical regulator of Ca(2+)-mediated o

184 Double-knockout mice lacking MCL-1 and cyclophilin D, an essential regulator of the mPTP, exhib

185 nuclear, p53, PEPCK1, superoxide dismutase, cyclophilin D, and Hsp10, and analyzed the deacetylation

186 nthase complex promoted its interaction with cyclophilin D, and sensitized the opening of mitochondri

187 are formed via regulated necrosis involving cyclophilin D, and that they may be targeted independent

188 PR formation is shear-dependent and requires cyclophilin D, calpain, and Rac1 activation.

189 ice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administration of L-a

190 rs including reactive oxygen species, matrix cyclophilin D, Pi (inorganic phosphate), and matrix pH.

191 reported sirtuin substrate proteins such as cyclophilin D, superoxide dismutase, and PEPCK1 were not

192 sporin A inhibits pore opening by binding to cyclophilin D, which interacts with the pore.

193 l intermittent hypoxic (IH) stress activated cyclophilin D-dependent mitochondrial proton leak and un

194 Our study identified the cyclophilin D-dependent mitochondrial proton leak and un

195 Similarly, the cyclophilin D-inhibiting drug alisporivir and the acid s

196 Compared with WT mice, cyclophilin D-knockout littermates did not develop bioen

197 These pathologic responses were abrogated in cyclophilin D-knockout mice.

198 er may involve the peptidyl prolyl isomerase cyclophilin D.

199 oes not provide the site of interaction with cyclophilin D.

200 n be inhibited by cyclosporin A mediated via cyclophilin D.

201 arges the c-subunit ring and unhooks it from cyclophilin D/cyclosporine A binding sites in the ATP sy

202 Cyclophilin-D (Cyp-D) is a mitochondrial matrix peptidyl

203 the mitochondrial peptidyl prolyl isomerase cyclophilin-D (Cyp-D) reduces Vo(2).

204 Accordingly, cyclophilin-D and mPTP were increased in heterozygous he

205 HAX-1 were mediated through interference of cyclophilin-D binding to heat shock protein-90 (Hsp90) i

206 Suppression of cyclophilin-D expression or enforced detachment of hexok

207 heterozygous hearts, but genetic ablation of cyclophilin-D in these hearts significantly alleviated t

208 Improved exercise capacity in cyclophilin-D knockout mice associated with enhanced oxy

209 Mechanistically, alterations in cyclophilin-D levels by HAX-1 were contributed by the ub

210 re attributed to specific down-regulation of cyclophilin-D levels leading to reduction in mPTP activa

211 dings reveal the role of HAX-1 in regulating cyclophilin-D levels via an Hsp90-dependent mechanism, r

212 AX-1 overexpressing cardiomyocytes increased cyclophilin-D levels, as well as mPTP activation upon ox

213 ion, whereas proteosomal inhibition restored cyclophilin-D levels.

214 HAX-1 overexpression enhanced cyclophilin-D ubiquitination, whereas proteosomal inhibi

215 sirtuin-3 activity led to the activation of cyclophilin-D, which mediated an increased binding of he

216 tant mitochondrial calcium overload triggers cyclophilin-D-mediated necrosis.

217 oassays revealed decreased virulence for two cyclophilins (DeltaBbCypE and DeltaBbCyp6) and the simul

218 se findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclop

219 demonstrates a complex relationship between cyclophilin dependence and MxB sensitivity likely driven

220 They include the strong cyclophilin dependency of the life cycle of many coronav

221 pA was found to be the most highly expressed cyclophilin during growth and purified recombinant BbCyp

222 Extracellular cyclophilins (eCyps) have been identified as a novel cla

223 papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of most of the major

224 rthermore, isomerization is regulated by the cyclophilin family of peptidyl-prolyl isomerases, highli

225 anding the role of each immunophilin family, cyclophilins, FK506 binding proteins (FKBPs), and parvul

226 The structure revealed a typical cyclophilin fold consisting of a compact beta-barrel mad

227 eof, suggesting an overlapping dependency on cyclophilins for replication.

228 logical idiosyncrasy stemming from potential cyclophilin functions, we generated mice lacking endogen

229 enic fungus, Beauveria bassiana, contains 11 cyclophilin genes whose roles were probed via individual

230 estingly, Cns1p and the TPR-containing Cpr7p cyclophilin have similar inhibitory functions during TBS

231 clophilin C as an endoplasmic reticulum (ER) cyclophilin in addition to cyclophilin B.

232 e activity of 9 small-molecule inhibitors of cyclophilins in an assay of CypD activity.

233 results revealed common and unique roles for cyclophilins in B. bassiana and validate a method for ex

234 The roles of individual cyclophilins in drug response was evaluated by small int

235 Alisporivir inhibition of cyclophilins in hepatocyte cell lines reduces replicatio

236 le for the cytosolic single-domain Cpr1-like cyclophilins in RNA virus replication.

237 lds has produced many analogues that inhibit cyclophilins in vitro but have reduced immunosuppressive

238 treatment with small molecule inhibitors of cyclophilins, including the approved drug cyclosporine,

239 f next-generation immunotherapeutics against cyclophilin-induced allergies.

240 atly upregulated inflammatory proteins (e.g. cyclophilin, inducible nitric oxide synthase, annexins,

241 Cyclophilin inhibition has been a target for the treatme

242 ssive analogue of cyclosporine A with potent cyclophilin inhibition properties that has reached phase

243 d be duplicated by incubating cells with the cyclophilin inhibitor cyclosporine A, a treatment that t

244 residue in trialysin and is inhibited by the cyclophilin inhibitor cyclosporine A.

245 lisporivir, a host-targeting antiviral, is a cyclophilin inhibitor that indirectly targets NS5A by bl

246 Alisporivir (ALV) is a cyclophilin inhibitor with pan-genotypic activity agains

247 nd by substitutions conferring resistance to cyclophilin inhibitor.

248 We investigated the effects of 2 cyclophilin inhibitors (alisporivir and NIM811) on HBV r

249 Three nonimmunosuppressive cyclophilin inhibitors (alisporivir, SCY-635, and NIM811

250 Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for th

251 Recent publications suggest that cyclophilin inhibitors may have utility for the treatmen

252 Cyclophilin inhibitors such as alisporivir have shown st

253 In this study, a set of macrocyclic cyclophilin inhibitors was synthesized based on the core

254 pounds in the search for orally bioavailable cyclophilin inhibitors.

255 nformation on cross-reactive IgE-epitopes of cyclophilins is available.

256 Calcium-modulating cyclophilin ligand (CAML) is an endoplasmic reticulum re

257 membrane activator and calcium-modulator and cyclophilin ligand (TACI).

258 ansmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) are found in 8% to

259 ansmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) controls differenti

260 membrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) was severely reduce

261 membrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), is a key molecule

262 ransmembrane activator calcium modulator and cyclophilin ligand interactor (TACI).

263 membrane activator and calcium modulator and cyclophilin ligand interactor) on GC B cells, thus limit

264 ansmembrane activator and calcium-modulating cyclophilin ligand interactor.

265 in combination with CAML (calcium-modulating cyclophilin ligand), which is not homologous to Get2.

266 erentiation factor 88 and calcium-modulating cyclophilin ligand.

267 UMO-1 and S1-binding mutations in the Ranbp2 cyclophilin-like domain.

268 The structure reveals that the CTD adopts a cyclophilin-like fold with a non-canonical active-site c

269 or protein OsIAA11 along with its associated cyclophilin LRT2 are essential components in a negative

270 n by T. cruzi, indicating that extracellular cyclophilin may be critical to adaptation in other insec

271 Specific cyclophilin mutants showed impaired hyphal growth and di

272 A cyclophilin OsCYP20-2 with a variant interacts with SLEN

273 M811, indicating that Cs-sensitive host cell cyclophilins other than CypA contribute to the activity

274 no selectivity between the tightly conserved cyclophilin paralogs and exhibit significant off-target

275 proteostatic impairment of two novel Ranbp2 cyclophilin partners, the cytokine-responsive effectors,

276 We further show that host cell cyclophilins play an important role in regulating these

277 nd basophil degranulation with sera from all cyclophilin-positive patients.

278 se and chaperone activities reflect distinct cyclophilin properties.

279 e physiological roles and substrates of most cyclophilins remain unknown.

280 xtensive cross-reactivity with various other cyclophilins reported as allergens from diverse sources

281 eted gene knockouts or overexpression of any cyclophilin resulted in temperature sensitivity (TS).

282 nt models, experiments on the involvement of cyclophilins revealed little, if any, role for these cel

283 Here, an 18-kDa IgE-reactive cyclophilin (Rhi o 2) was purified from Rhizopus oryzae,

284 This work demonstrates that cyclophilin serves as molecular sensor leading to the ev

285 in tomato, translocation of a phloem-mobile cyclophilin, SlCyp1, from a wild-type scion into a mutan

286 report, we examined the contributions of the cyclophilin subset of peptidyl-prolyl isomerases to prot

287 ound that cleavage is largely independent of cyclophilins, suggesting that cyclophilins act either in

288 main of RNA polymerase II and is a divergent cyclophilin that carries the additional loop KSGKPLH, in

289 esence of peptidyl prolyl isomerases such as cyclophilins that accelerate the intrinsically slow isom

290 lude that HIV-1 has evolved to use CPSF6 and cyclophilins to cloak its replication, allowing evasion

291 en PPIase and chaperone activities of Ranbp2 cyclophilin toward proteostasis of selective substrates

292 In addition, cyclophilin-trialysin complexes enhance the production o

293 Parasites exposed to cyclophilin-trialysin have enhanced binding and invasion

294 Calcineurin phosphatase activity of cyclophilin-trialysin-treated parasites was higher than

295 tivity and allergenic activity of the hybrid cyclophilin were greater than that of CPR1.

296 , an endocuticle structural glycoprotein and cyclophilin, were able to interact directly with the TSW

297 ins, endocuticle structural glycoprotein and cyclophilin, were found to be consistent interactors wit

298 Cyclophilins, which are a large family of cellular proly

299 Our data reveal a cyclophilin with a variant with dual-localization in chl

300 Noncatalytic mutations affecting the only cyclophilins with known but distinct physiological subst