ライフサイエンスコーパス: cyclopropane

1 hich upon reductive elimination releases the cyclopropane.

2 he usually inert sites of the donor-acceptor cyclopropane.

3 etabolites possessing a masked electrophilic cyclopropane.

4 ketone to form an enone containing the vinyl cyclopropane.

5 rgy (1.8 kcal/mol) of a cyclobutane versus a cyclopropane.

6 regioselective anti-Markovnikov cleavage of cyclopropane.

7 alkylates DNA with an unusual electrophilic cyclopropane.

8 ylation of the C-C sigma bonds of alkylidene cyclopropanes.

9 ipolar cycloaddition chemistry of azides and cyclopropanes.

10 ts together three acetophenones to construct cyclopropanes.

11 ither diastereomer of di- and trisubstituted cyclopropanes.

12 dity and lipophilicity of monofunctionalized cyclopropanes.

13 a highly regioselective aminofluorination of cyclopropanes.

14 access to synthetically useful hydroxymethyl cyclopropanes.

15 cloisomerization of enynes to trisubstituted cyclopropanes.

16 cycloaddition of nitrones to donor-acceptor cyclopropanes.

17 -based carbonylative C-C bond activations of cyclopropanes.

18 ross-couplings, affording highly substituted cyclopropanes.

19 ve small-size rings such as cyclobutanes and cyclopropanes.

20 on of acyclic cinnamyl chlorides to strained cyclopropanes.

21 and green approach towards the synthesis of cyclopropanes.

22 approach for the synthesis of functionalized cyclopropanes.

23 alogous to that observed with donor-acceptor cyclopropanes.

24 opening cyclizations of donor-acceptor (D-A) cyclopropanes.

25 nd to be stereospecific as in the case of DA cyclopropanes.

26 and enamides to afford 1,2,3-trisubstituted cyclopropanes.

27 catalyzed enantioselective C-H activation of cyclopropanes.

28 olds affords multifunctional, donor-acceptor cyclopropanes.

29 sigma-bond activation of strained alkylidene cyclopropanes.

30 g by the more mature field of donor-acceptor cyclopropanes.

31 tioselective methods for the ring opening of cyclopropanes.

32 nish a variety of enantiopure trisubstituted cyclopropanes.

33 nish a variety of enantiopure trisubstituted cyclopropanes.

34 -C bond activation of "simple" electron poor cyclopropanes.

35 emains difficult, especially for unactivated cyclopropanes.

36 The ring-opening of cyclopropane-1,1-dicarboxylates with vicinal donor aryl

37 trans-2-Aryl-3-nitro-cyclopropane-1,1-dicarboxylates, upon treatment with BF3

38 rived from 1'-methyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoline] (6) and 6'-chloro-1'-methyl

39 6'-chloro-1'-methyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,2'-quinoline] (7) are 3.5 x 10(2) s(-1) a

40 ctron (NIPE) spectra of the radical anion of cyclopropane-1,2,3-trione, (CO)3(*-), have been obtained

41 by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones reported herein.

42 by the bioisosteric 2-(1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones, e.g., 3.

43 through a nucleophilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the azide ion.

44 l)amino)isoxazol-5 -yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid) in rhesus monkeys to ima

45 roach for the dimerization of donor-acceptor cyclopropanes (2-arylcyclopropane-1,1-dicarboxylates) un

46 The synthetic sequence starts with the cyclopropane 3 and involves intramolecular Heck alkenyla

47 inane 34 or mixtures of cyclobutanone 36 and cyclopropane 38, respectively.

48 lkene moiety, subsequent ring-opening of the cyclopropane affords either cyclopentane or cyclohexane

49 (1H)one derivatives was achieved by reacting cyclopropane aldehydes with N'-aryl anthranil hydrazides

50 n demonstrated for the synthesis of a chiral cyclopropane aldol and a gamma-lactone in a >95:5 diaste

51 f one tripeptide incorporating a fluorinated cyclopropane amino acid (FCAA) analogue is reported.

52 tuted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step

53 (1), and a less active but extremely stable cyclopropane analog 2, which is currently undergoing pre

54 und: a straightforward decoordination of the cyclopropane and a cationic rearrangement of the three-m

55 The shielding pattern arising from the cyclopropane and cyclobutane CC framework response to a

56 ocol to access carbazole from donor-acceptor cyclopropane and indonyl alcohol via [3+3] annulation in

57 -catalyzed annulation between donor-acceptor cyclopropane and N-tosylaziridinedicarboxylate to access

58 pproaches based on the reaction of nonchiral cyclopropanes and (dynamic) kinetic resolutions and asym

59 sformation (DyKAT) of racemic donor-acceptor cyclopropanes and (E)-aldimines.

60 leophilic ring-opening products from the D-A cyclopropanes and 1-naphthylamines and their subsequent

61 d styrenes under Rh2(OAc)4 catalysis to give cyclopropanes and dihydrofurans in a highly regioselecti

62 We describe the synthesis of a variety of cyclopropanes and epoxides by combining a readily access

63 rmal [3 + 2]-cycloaddition of donor-acceptor cyclopropanes and ketenes.

64 reported and is amenable to a variety of D-A cyclopropanes and primary amines.

65 age of different spiro-4-hydroxychroman-3,1'-cyclopropanes and similar thiochroman analogues.

66 Characterization of immune responses to the cyclopropane- and MAMT-deficient strains indicated that

67 The imine, unsaturated lactam, and cyclopropane are essential for efficient DNA alkylation.

68 Trifluoromethyl-substituted cyclopropanes are an attractive family of building block

69 Cyclopropanes are important structural motifs found in n

70 lectron oxidation, the relatively inert aryl cyclopropanes are readily converted into reactive radica

71 yclization reactions of donor-acceptor (D-A) cyclopropanes are recognized as versatile methods for co

72 tive ring opening of acceptor- or donor-only cyclopropanes are then presented.

73 Furthermore, the role of D-A acceptor cyclopropanes as reactive subunits in natural product sy

74 for the synthesis of highly enantioenriched cyclopropanes as single diastereoisomers.

75 ique cyclopropane natural products or use of cyclopropanes as versatile strategic intermediates.

76 Comparisons to alkenes, cyclopropanes, aziridines, thiiranes, and phosphiranes a

77 For cyclopropanes bearing a trisubstituted alkenyl group eit

78 ss-coupling to form diverse tetrasubstituted cyclopropanes bearing all-carbon quaternary stereocenter

79 This strengthens the idea that cyclopropane behaves as a quasi-double bond.

80 phospholipid head group and in the number of cyclopropane bond containing fatty acids.

81 t energy dissipation by fragmentation of the cyclopropane bond is also proposed.

82 t, which subsequently fragments the strained cyclopropane bond to give a lower energy and unreactive

83 atom bends 31 degrees toward the endo-fused cyclopropane bond, elongating it to r = 1.69 A.

84 llowed by cleavage of one of the two C-CH(2) cyclopropane bonds as previously proposed by the Fabian

85 ther undergoes spontaneous cyclizations to a cyclopropane-bridge-containing hexacyclic framework that

86 port the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting

87 an be used to produce a product that lacks a cyclopropane but retains a quaternary stereogenic center

88 > n-BuI > n-BuBr approximately (bromomethyl)cyclopropane (but t-Bu2C horizontal lineO < ClSiMe3 in T

89 strain energies exceeding those of saturated cyclopropanes by >10 kcal/mol.

90 ric synthesis of trifluoromethyl-substituted cyclopropanes by means of myoglobin-catalyzed olefin cyc

91 ereoselective synthesis of cis-disubstituted cyclopropanes by the Au(I)/PPh(3)-catalyzed cycloadditio

92 Directed intramolecular protonolyis of the cyclopropane C-C bond is demonstrated as a strategy to g

93 f TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped.

94 bles highly enantioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetim

95 tion is stereospecific, and optically active cyclopropanes can be reacted with high optical purities

96 -type ring expansion of the aryl-substituted cyclopropane carbaldehydes with the hydroxylamine salt i

97 Additionally, employing cyclopropane carboxaldehydes led to ring-opened products

98 act with Michael acceptors to give esters of cyclopropane carboxylic acids substituted with p-nitroar

99 The borylation of cyclopropanes catalyzed by the combination of (eta(6)-me

100 The subsequent beta-hydride elimination and cyclopropane cleavage are competitive, determining the e

101 In trans-VCP, the cyclopropane cleavage is intrinsically favored and leads

102 acyclopentene intermediate, in contrast to a cyclopropane cleavage pathway in the reaction with Rh(I)

103 acid induced isomerization of donor-acceptor cyclopropanes, containing an alkenyl moiety and diverse

104 designed and synthesized a series of chiral cyclopropane-containing alpha4beta2-specific ligands tha

105 heterogeneous catalyst for the formation of cyclopropane-containing products.

106 from Capitella teleta (Ct) in complex with a cyclopropane-containing selective alpha4beta2-nicotinic

107 A 3-pyridyl ether scaffold bearing a cyclopropane-containing side chain was recently identifi

108 nabled the multigram synthesis of the chiral cyclopropane core of four drugs (Tranylcypromine, Tasime

109 in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes

110 ries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes

111 ess for (4 + 2)-annulation of donor-acceptor cyclopropanes (DACs) with unsaturated compounds in the p

112 losis would be viable and what the effect of cyclopropane deficiency on virulence would be.

113 However, it is unknown whether a cyclopropane-deficient strain of M. tuberculosis would b

114 ize the peculiar (1)H NMR chemical shifts of cyclopropane (delta 0.22) and cyclobutane (delta 1.98) w

115 intermediate to afford the cis-disubstituted cyclopropane derivative in a high cis/trans diastereomer

116 In this work, ring-opening reactions of cyclopropane derivatives under hydrogen catalyzed by met

117 to a number of densely functionalized chiral cyclopropane derivatives, including alpha-cyclopropyl-be

118 n the cyclohexyl system, a small amount of a cyclopropane derived from 1,3-hydrogen migration occurs,

119 he substituents on both the carbinol and the cyclopropane determine both chemo- and stereoselective o

120 ucture, which favor the formation of the cis-cyclopropane diastereomer of 1 R,2 S absolute configurat

121 With SnCl4, the cyclopropane dicarboxylates afforded cyclopentene deriva

122 nes when subjected to cycloaddition with the cyclopropane diester afford a trouble-free formulation o

123 luoromethyl groups to olefins and access 1,1-cyclopropane diesters.

124 e styrene, we synthesized non-natural phenyl cyclopropanes directly from D-glucose in single-vessel f

125 The cyclopropane donor substituents determine the overall re

126 roducts are observed with highly stabilizing cyclopropane donor substituents.

127 transport calculations, which show that the cyclopropane dumbbell gives a higher calculated single-m

128 of spectroscopic techniques reveals that the cyclopropane dumbbell possesses better electronic commun

129 gold(I) carbene reacts with alkenes to form cyclopropanes either intra- or intermolecularly.

130 expected to find utility in the synthesis of cyclopropanes, epoxides and their derivatives, as well a

131 s decrease was accompanied by an increase in cyclopropane FA content, this was not at the expense of

132 Cyclopropane fatty acids (CPAs) are desirable as renewab

133 Cyclopropane fatty acids (CPAs) are useful feedstocks fo

134 limidazolium chloride include an increase in cyclopropane fatty acids in the cell membrane, scavengin

135 5) higher total percentages of saturated and cyclopropane fatty acids than did control cells.

136 of unsaturated fatty acids and low levels of cyclopropane fatty acids, (iii) increased membrane fluid

137 synthesis of cis-configured trifluoromethyl cyclopropanes for a broad range of substrates with excel

138 amolecular transformations of donor-acceptor cyclopropanes for cycloisomerizations, formal cycloaddit

139 ough the catalytic oxidative ring-opening of cyclopropanes for the synthesis of 1,3-fluoroacetoxylate

140 e elongation of FA(16:1) to FA(18:1) and not cyclopropane formation.

141 he construction of polycyclic compounds with cyclopropane fragments.

142 ctive synthesis of novel multifunctionalized cyclopropanes from gamma,delta-epoxy malonates and amine

143 t of common readily available donor-acceptor cyclopropanes, functionalized with ester, keto, nitro, c

144 tes over alpha-mycolates and devoid of trans-cyclopropane functions.

145 and bridged benzomorphanones, starting from cyclopropane-fused benzomorphanothiones and benzomorphan

146 bonyl compounds furnishes the donor-acceptor cyclopropane-fused benzoxa[3.2.1]octane scaffold with ex

147 ntramolecular cyclopropanations resulting in cyclopropane-fused gamma-lactones, which are key motifs

148 fforded medicinally relevant benzoindolines, cyclopropane-fused indenopyridines, pyrroloquinolines, o

149 n situ from enoldiazo compounds that produce cyclopropane-fused ring systems.

150 containing Tet-v2.0 reacts selectively with cyclopropane-fused trans-cyclooctene (sTCO) with a bimol

151 er mechanism for the asymmetric synthesis of cyclopropane-fused-delta-lactones, which are key structu

152 he interactions of the Walsh orbitals of the cyclopropane group with the breaking C-N bonds in N2 los

153 t a dimethyl group at C4 as well as a C9,C19 cyclopropane group, as found in oryzanol, negatively aff

154 As the cyclopropane has been shown to be essential for genotoxi

155 ituted C-C bond of the cis-1,2-disubstituted cyclopropane has steric repulsions from the substituent,

156 Donor-acceptor cyclopropanes have been evaluated as substrates for reac

157 led acid-catalyzed cleavage of the resulting cyclopropane (HCl), further improvements in a unique int

158 Cyclopropane hemimalonates, when treated with sodium azi

159 ClbS or an active site residue mutant reveal cyclopropane hydrolase activity that converts the electr

160 a molecular-level view of the first reported cyclopropane hydrolase and support for a specific mechan

161 ystems, vicinal quaternary centers, and even cyclopropanes in good yield.

162 ange of alkenes, affording the corresponding cyclopropanes in high yields with effective control of b

163 ted transfer hydrogenation of donor-acceptor cyclopropanes in the presence of aldehydes.

164 straightforward access to highly substituted cyclopropanes in two steps from commercially available a

165 wn that the reactivity of the donor-acceptor cyclopropane increases with the increase of the electron

166 to divert the mechanistic pathway toward the cyclopropane instead of the previously obtained benzocyc

167 ed to gain access to not only monobrominated cyclopropanes, interesting building blocks for further u

168 a design in which a reactive donor-acceptor cyclopropane intermediate is generated by in situ conden

169 cin C, involving a novel electrophilic spiro-cyclopropane intermediate is hypothesized.

170 esses or transformations through nonisolable cyclopropane intermediates generated from cyclopropenes.

171 rising from an aromatic-like ring current in cyclopropane, involving six electrons in the three C-C b

172 to show in this review that the cleavage of cyclopropane is a powerful approach to reveal sp(3) ster

173 opropane substrate, the substituent from the cyclopropane is away from the reaction center in both pa

174 h of the two diastereotopic C-CH(2) bonds of cyclopropane is cleaved in the second step of the proces

175 her the more or less substituted C-C bond of cyclopropane is cleaved.

176 iles at the donor position of donor-acceptor cyclopropanes is described, representing an inversion of

177 n between cyclopropenones and donor-acceptor cyclopropanes is described.

178 A novel organocatalytic activation mode of cyclopropanes is presented.

179 lorotetrahydropyrans to afford disubstituted cyclopropanes is reported.

180 intermolecular reactivity of donor-acceptor cyclopropanes is widely reported, reviews that center on

181 -carbon analogue of these species (methylene cyclopropane) is only briefly discussed.

182 gaseous constituents butane, carbon dioxide, cyclopropane, isobutylene, and methane.

183 These highly potent cyclopropane ligands possess superior subtype selectivit

184 The racemic cyclopropane-linked compounds showed PLK4 affinity and a

185 Optimization of this new cyclopropane-linked series was based on a computational

186 gment ions spaced 14 Da apart, thus enabling cyclopropane localization.

187 ch is governed by rapid isomerization of the cyclopropane moieties at ~1.2 nN, from the force-rate co

188 rization of 1,6-diynes bearing an alkylidene cyclopropane moiety has been developed.

189 s a large preference for N2 loss anti to the cyclopropane moiety rather than syn from adducts formed

190 of the initial S(N)2-like imine attack on a cyclopropane molecule together with a high diastereosele

191 tegic considerations for introduction of the cyclopropane motif in a collection of recent total synth

192 ed to enable the synthesis of various unique cyclopropane natural products or use of cyclopropanes as

193 stereoselective synthesis of polysubstituted cyclopropanes nowadays allow chemists to easily access t

194 also carried out, and a revised C-H BDE for cyclopropane of 108.9 +/- 1.0 kcal mol(-1) is recommende

195 ase activity that converts the electrophilic cyclopropane of the colibactins into an innocuous hydrol

196 vergent fragment coupling via a nucleophilic cyclopropane opening, a highly diastereoselective formal

197 ules have been synthesized containing either cyclopropane or pyrrolidine rings connecting two fullere

198 a wide variety of products by attack at the cyclopropane or the carbene carbons.

199 esence of MgI2 as Lewis acid, donor-acceptor cyclopropanes or corresponding cyclobutanes were treated

200 The role of protonated cyclopropane (PCP(+)) structures in carbocation rearrang

201 Complex molecular architectures containing cyclopropanes present significant challenges for any syn

202 r-membered palladacycle intermediate and the cyclopropane product is favored.

203 We describe the formation of a bis-cyclopropane product, a tricyclic[4.1.0.0(2,4)]heptane,

204 by radical C-C bond formation generates the cyclopropane product.

205 c alkenes to obtain C(sp(2))-H alkylation or cyclopropane products are valuable transformations for s

206 under mild conditions, affording the desired cyclopropane products in high yields with both high dias

207 literature, many examples of these polarized cyclopropanes' reactivity with nucleophiles, electrophil

208 A vinyl cyclopropane rearrangement embedded in an iridium-cataly

209 ing step involves a difluorocarbene addition/cyclopropane rearrangement sequence.

210 Theoretical investigation of cyclopropane-to-cyclopropane rearrangements of sterols indicates a role

211 Cyclopropanes represent a class of versatile building bl

212 In this chemistry, the cyclopropane ring acts as a reporter of leaving-group re

213 sigma-interaction between the C-C bond of a cyclopropane ring and the Hf.

214 acilitate the homolytic fragmentation of the cyclopropane ring and the subsequent radical cyclization

215 ross-ring C-C cleavages on both sides of the cyclopropane ring are observed for cyclopropyl lipids, r

216 Important features of the cyclopropane ring are, the (1) coplanarity of the three

217 , respectively, which are spirolinked to the cyclopropane ring at carbon 2.

218 ne scaffold (I), the relocation of the fused cyclopropane ring bond and the shifting of the oxygen at

219 catalyzes a cryptic chlorination leading to cyclopropane ring formation in the synthesis of the natu

220 One example involved cyclopropane ring formation, and the other carbon-carbon

221 highly substituted and sterically encumbered cyclopropane ring have been isolated from the marine red

222 Efforts to substitute the cyclopropane ring in a series of aryl cyclopropylnitrile

223 form unsaturated imines that alkylate DNA by cyclopropane ring opening (2 --> 3).

224 N-(2-phenylcyclopropyl)aniline (8) undergoes cyclopropane ring opening with a rate constant of 1.7 x

225 e the corresponding radical cation undergoes cyclopropane ring opening with a rate constant of only 4

226 t meet the stereoelectronic requirements for cyclopropane ring opening.

227 electively at the methylene C-H bonds of the cyclopropane ring over methine or methyl C-H bonds.

228 The cyclopropane ring takes part in pi-acceptor hydrogen bon

229 20% bicyclogermacrene, a hydrocarbon with a cyclopropane ring that underlines the dual 1,10-/1,11-cy

230 dition of the distal carbon-carbon bond of a cyclopropane ring to the palladium(0) catalyst and the r

231 ctionalized bicyclic sugar unit to which the cyclopropane ring was introduced via carbene addition.

232 hanism, and the peculiar contribution of the cyclopropane ring, have been scrutinized via DFT calcula

233 Oxidative cyclopropane ring-opening of 5-substituted 3-azabicyclo[

234 at solvent may play an important role in the cyclopropane ring-opening step.

235 f other processes involving the opening of a cyclopropane ring.

236 poxides with the alkene double bond to yield cyclopropane rings are presented.

237 Cyclopropane rings have been correlated with tolerance t

238 Opening of both cyclopropane rings in 2'-aryl-1,1'-bicyclopropyl-2,2-dic

239 (UVPD-MS) for structural characterization of cyclopropane rings in bacterial phospholipids and MAs.

240 insight into the importance of mycolic acid cyclopropane rings in the PMB and provide the first evid

241 The cyclopropane rings of both agents displace a single wate

242 on modes and afford localization of multiple cyclopropane rings within a single lipid.

243 rium tuberculosis cell wall, are modified by cyclopropane rings, methyl branches, and oxygenation thr

244 n branched fatty acids that are decorated by cyclopropane rings.

245 (OTf)(3) also results in the opening of both cyclopropane rings.

246 fail to reveal the presence and position of cyclopropane rings.

247 ce of modifications such as double bonds and cyclopropane rings.

248 ine, and arginine) from a unique fluorinated cyclopropane scaffold is described.

249 catalyst, the organocatalytically activated cyclopropanes show an unexpected and highly stereoselect

250 This leads to a cyclopropane-stabilized carbocation, which triggers ring

251 e studies demonstrate how the combination of cyclopropane strain release and the templating effect of

252 cause of the weak acidity of alpha C-H bond (cyclopropanes), strong sensitivity of the strained ester

253 ency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by

254 In the trans-1,2-disubstitued cyclopropane substrate, the substituent from the cyclopr

255 ents and can engage a variety of substituted cyclopropane substrates.

256 plied to effect methylene C-H olefination of cyclopropane substrates.

257 In this reaction, cyclobutanones serve as cyclopropane surrogates, reacting in a formal (4+2-1) tr

258 ulating crop, we expressed nine higher plant cyclopropane synthase (CPS) enzymes in the seeds of fad2

259 nes coexpressing LcPDCT and Escherichia coli CYCLOPROPANE SYNTHASE (EcCPS) showed up to a 50% increas

260 ential and sits upstream of cmaA2 encoding a cyclopropane synthase dedicated to keto- and methoxy-MAs

261 Here, we demonstrated that mycolic acid cyclopropane synthase PcaA, but not MmaA2, was phosphory

262 at pH 1) relative to N-Boc-CBI containing a cyclopropane (t(1/2) = 133 h at pH 3) may be attributed

263 ing the synthesis, we isolated an unexpected cyclopropane that presumably stems from a carbonium ion

264 o- and diastereoselectivity to afford unique cyclopropanes that can be further functionalized to prov

265 In the case of cyclopropane, the CC framework shielding pattern implies

266 least substituted carbon-carbon bond of the cyclopropane to form a platinacyclobutane intermediate.

267 rmal [3 + 2]-cycloaddition of donor-acceptor cyclopropanes to 1,3-dienes.

268 pecifically, upon exposure of donor-acceptor cyclopropanes to alcohols in the presence of a cyclometa

269 s] via [3+2]-cycloaddition of donor-acceptor cyclopropanes to electron-poor ketimines, iminooxindoles

270 c C-C-bond activation of electron-poor vinyl cyclopropanes to generate synthetically useful a1,a3,d5-

271 acyclopentanones that arise upon exposure of cyclopropanes to Rh(I) catalysts and CO.

272 Theoretical investigation of cyclopropane-to-cyclopropane rearrangements of sterols i

273 ic Rh(I)-catalyst systems, amino-substituted cyclopropanes undergo carbonylative cycloaddition with t

274 The choice of N-substituent on the cyclopropane unit controls the oxidation level of the pr

275 ene (1) by the single bond in the endo-fused cyclopropane unit of carbene 3 led to similar outcomes.

276 a general strategy for the 1,3-oxidation of cyclopropanes using aryl iodine(I-III) catalysis, with e

277 eta-unsaturated imines or alpha-(iminomethyl)cyclopropanes via a Ti(II)/Ti(IV) redox cycle.

278 ocol toward amino-substituted donor-acceptor cyclopropanes via the formal nucleophilic displacement i

279 bly line and incorporating two electrophilic cyclopropane warheads into the final natural product sca

280 y selective construction of poly-substituted cyclopropanes which can be transformed into acyclic deri

281 ing oxo-amination of electronically unbiased cyclopropanes, which enables the expedient construction

282 generation catalyst) gives the corresponding cyclopropane with an enantiomeric ratio of 70/30 and, th

283 exclusively obtained in yield of 51-99% when cyclopropanes with a 2-substituted alkenyl group as a do

284 for the [4 + 2] annulation of donor-acceptor cyclopropanes with acetylenes under the effect of anhydr

285 ing opening reaction of Donor-Acceptor (D-A) cyclopropanes with alkyl hydroperoxides is reported to f

286 d oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to

287 ranones, based on reaction of donor-acceptor cyclopropanes with dienes, has been developed.

288 able of providing access to 1-carboxy-2-aryl-cyclopropanes with high trans-(1R,2R) selectivity and ca

289 th BCB-Bpin at the beta'-position leading to cyclopropanes with high trans-selectivity.

290 romide ion, and halogenation of intermediate cyclopropanes with N-bromo- or N-iodosuccinimide.

291 of gamma-butyrolactone-fused donor-acceptor cyclopropanes with nitriles has been explored for the ac

292 opane-1,1-diesters as well as donor-acceptor cyclopropanes with other types of electron-withdrawing a

293 hese gamma-cyanoesters by direct reaction of cyclopropanes with sodium cyanide under typical S(N)2 co

294 egioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH reductive system was deve

295 rd method for ring opening of donor-acceptor cyclopropanes with trimethylsilyl cyanide as a surrogate

296 ncyclilizing 1,3-bisfunctionalization of D-A cyclopropanes with two different functional groups and r

297 on of aroyl-substituted donor-acceptor (D-A) cyclopropanes with two equivalents of 1-naphthylamines i

298 pwise 1,3-dipolar cycloadditions with 3) and cyclopropanes (with 4 and 5), respectively.

299 ubstrate spiro[bicyclo[2.2.1]hept-2-ene-7,1'-cyclopropane] with Pt(II) catalysts such as (Me2bpy)PtPh

300 related N chelates afford comparatively low cyclopropane yields (</=20 %).