ライフサイエンスコーパス: cyclopropyl

1 clusive migration of the boracycle (hexynyl, cyclopropyl).

2 = methyl, benzyl, t-butyl, 1-adamantyl, and cyclopropyl.

3 l inhibitors, which are represented by N-[(5-cyclopropyl-1,2-oxazol-3-yl)methyl]adamantan-1-amine (WJ

4 clopropyl trimethylsilylmethyl ketone gave 1-cyclopropyl-1-trimethylsilylethylene, a product of exclu

5 , enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole has the (1S,2S) absolute confi

6 , enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole with the absolute configuratio

7 Treatment of the 6-N-cyclopropyl-2',3'-di-O-isopropylideneadenosine 5'-aldehy

8 luation iteration led to the highly active 5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-me

9 ous effectors and the allosteric activator 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyr

10 -cGMP or the NO-independent sGC stimulator 5-cyclopropyl-2[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b] pyr

11 is of the corresponding chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-benzothiadiazine 1,1-dioxides

12 In addition, TTA-Q4 [(S)-4-(6-chloro-4-cyclopropyl-3-(2,2-difluoroethyl)-2-oxo-1,2,3,4-tetrahyd

13 enamide, and beta-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to

14 analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and beta-m

15 ibitor properties of several 1-methyl- and 1-cyclopropyl-4-aryl-1,2,3,6-tetrahydropyridine derivative

16 cterization of LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxo

17 ) potentiator, LY2119620 (3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxo

18 arboxyphenylglycine (MCPG) and/or (RS)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) (group III a

19 eceptor (mGluR) II/III antagonist (RS)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) and by the b

20 ade of group III mGluRs with 300 microM (RS)-cyclopropyl-4-phosphonophenylglycine (CPPG) facilitated

21 h the mGluR6 receptor antagonist (R,S)-alpha-cyclopropyl-4-phosphonophenylglycine (CPPG).

22 he agonist with the mGluR6 antagonist (RS)-a-cyclopropyl-4-phosphonophenylglycine (CPPG).

23 The group III mGluR antagonist (R,S)-cyclopropyl-4-phosphonophenylglycine (CPPG, 300 microm)

24 tropic glutamate receptor antagonist (R,S)-a-cyclopropyl-4-phosphonophenylglycine had no effect on th

25 etabotropic glutamate antagonist, (RS)-alpha-cyclopropyl-4-phosphonophenylyglycine (CPPG), blocked li

26 An mGluR antagonist, (RS)-alpha-cyclopropyl-4-phosphonophenylyglycine (CPPG), blocked th

27 inolone 6, 8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4-quinolone-3-carboxyli c acid, but not to e

28 ters and cytotoxic agents with (12R,13S,15S)-cyclopropyl 5-methylpyridine epothilone A (11) as the mo

29 quent iodo- or protiodestannylation gave 6-N-cyclopropyl-5'-deoxy-5'-(iodomethylene)adenosine 8b or i

30 desirable in vitro biological profile was 9-cyclopropyl-6-fluoro-8-methoxy-7-(2-methylpyridin-4-yl)-

31 riment), the most potent compound was 11m (4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-1,2,4-be

32 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazi

33 4-cyclopropyl-7-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiaz

34 The mechanism of the reaction between cyclopropyl acid chlorides and imines to form 1,3-oxazin

35 to readily react with various donor-acceptor cyclopropyl acid chlorides, with complete regioselectivi

36 sponding alpha-silylcyclopentenols or (alpha-cyclopropyl)acylsilanes favor the [1,4]-pathway by ortho

37 he formation of two more CC bonds, affording cyclopropyl alcohol boronate esters with three new stere

38 intermediates in the synthesis of versatile cyclopropyl alcohol boronate esters, which are valuable

39 s enable the synthesis of a diverse array of cyclopropyl alcohol building blocks with high enantio- a

40 ve methods for the synthesis of a variety of cyclopropyl alcohols are reported.

41 disubstituted cyclopropyl alcohols, and anti-cyclopropyl alcohols from achiral precursors.

42 lopropanation provides syn-cis-disubstituted cyclopropyl alcohols in 42-70% yield, 88-97% ee, and > 1

43 Workup with TBAF affords the anti-cyclopropyl alcohols in one pot in 60-82% yield, 89-99%

44 ith allyl bromides to generate the allylated cyclopropyl alcohols without loss of enantio- or diaster

45 cyclopropyl alcohols, syn-cis-disubstituted cyclopropyl alcohols, and anti-cyclopropyl alcohols from

46 esult of a cascade based on oxidation of the cyclopropyl alcohols, followed by aldol condensation wit

47 In the synthesis of vinyl cyclopropyl alcohols, hydroboration of enynes is followe

48 For the synthesis of cis-disubstituted cyclopropyl alcohols, in situ generated (Z)-vinyl zinc r

49 nt the first one-pot approaches to syn-vinyl cyclopropyl alcohols, syn-cis-disubstituted cyclopropyl

50 Because direct cyclopropanation provides syn-cyclopropyl alcohols, the intermediate allylic alkoxides

51 lkoxide-directed cyclopropanation to provide cyclopropyl alcohols.

52 to in situ cyclopropanation to furnish vinyl cyclopropyl alcohols.

53 ned cyclopentanes from Ph* methyl ketone and cyclopropyl alcohols.

54 In an alternate pathway, the cyclopropyl aldehyde acts as a mechanism-based irreversi

55 When reacted with cAD, the cyclopropyl aldehyde produces 1-octadecene as the rearra

56 ols, such as 2-methylcyclopropylmethanol, to cyclopropyl aldehydes using tert-butyl hydroperoxide as

57 with a range of aryl, heteroaryl, vinyl, or cyclopropyl aldimines in high yield and with excellent d

58 This reaction forms 1-cyclopropyl alkylamine derivatives in high yield and wit

59 amolecular Pd-catalyzed functionalization of cyclopropyl alpha-amino acid-derived benzamides proceeds

60 -Alder reaction of highly reactive beta,beta-cyclopropyl-alpha,beta-unstaturated N-acyloxazolidinones

61 onoamine oxidase, namely, phenylhydrazine, N-cyclopropyl-alpha-methylbenzylamine, and 1-phenylcyclopr

62 In the case of N-cyclopropyl-alpha-methylbenzylamine, masses correspondin

63 nylhydrazine was 10 times more potent than N-cyclopropyl-alpha-methylbenzylamine, which was much more

64 vior was also observed for other secondary N-cyclopropyl amides.

65 rated by converting the carboxylic acid into cyclopropyl amine without loss of optical activity.

66 During the biosynthesis of the cyclopropyl amino acid coronamic acid from l-allo-Ile by

67 sequent steps in the formation of this novel cyclopropyl amino acid.

68 The cyclopropyl amino acids derived from ketones proved to b

69 Cyclopropyl analogue 4 was identified as a CYP11B1 inhib

70 -we postulated that the corresponding carba "cyclopropyl" analogue would be a potent retaining beta-g

71 with DENSPM and (2R,10R)-(HO)(2)DENSPM, both cyclopropyl analogues diminished ornithine decarboxylase

72 yclic replacements of the thiazoline ring or cyclopropyl analogues of the core diene segment.

73 The cyclopropyl analogues were alternative substrates.

74 6)-(2,5-dichlorobenzyl) and N(6)-(2-phenyl-1-cyclopropyl) analogues 20 and 33 (1000), and the N(6)-(3

75 es also confirmed the importance of both the cyclopropyl and 5-methylpyridine moieties in conferring

76 is, and biological evaluation of a series of cyclopropyl and cyclobutyl epothilone analogues (3-12, F

77 on the enantiomeric form of abacavir at both cyclopropyl and cyclopentyl regions.

78 To probe the mechanism of the reaction, cyclopropyl and epoxy substrate analogues, designed to b

79 the epoxide units and lactone moieties with cyclopropyl and lactam structural motifs, respectively,

80 Content of cyclopropyl and omega-cyclohexyl fatty acids of microbia

81 alpha-Arylations of cyclopropyl and related nitriles provide access to impor

82 The use of cyclopropyl and thioether substrates support the radical

83 Cyclopropyl and vinyl boronic acids undergo very slow pr

84 ted ionization (MAI), the mechanism by which cyclopropyl and vinylidene carbenoids react with nucleop

85 yl, 5-iodo-2-methoxybenzyl, trans-2-phenyl-1-cyclopropyl, and 2,2-diphenylethyl.

86 Contributions from saturated, unsaturated, cyclopropyl, and branched bacterial fatty acids to the d

87 ings have been developed with both potassium cyclopropyl- and alkoxymethyltrifluoroborates.

88 Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl ch

89 chanisms of these HppE-catalyzed oxidations, cyclopropyl- and methylenecyclopropyl-containing compoun

90 n, and Wayner, the radical anions of several cyclopropyl- and oxiranyl-containing carbonyl compounds

91 ing of a wide variety of aryl-, heteroaryl-, cyclopropyl-, and vinylboronic acids with high selectivi

92 ichiometric amounts of zinc bromide produces cyclopropyl arenes in good to excellent yields.

93 macrolactone, the sugar callipeltose, and a cyclopropyl bearing chain.

94 trans-Cyclopropyl beta-amino acid derivatives can be synthesiz

95 al cyclopropane derivatives, including alpha-cyclopropyl-beta-amino acids.

96 rgo asymmetric, intramolecular silylation of cyclopropyl C-H bonds in high yields and with high enant

97 antioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-pro

98 50) = 0.19 +/- 0.03 nM) > 4-{3-[6-amino-9-(5-cyclopropyl-carbamoyl-3,4-dihydroxytetrahydrofuran-2-yl

99 ng the delocalized C2-C1-O system in the key cyclopropyl-carbene intermediate, which is enhanced by t

100 bene character as compared with that of free cyclopropyl carbenes.

101 Cyclopropyl carbinol derivatives undergo a regio- and st

102 used cyclohexa-1,3-dienes upon acid-promoted cyclopropyl carbinol ring opening.

103 zed ring-opening cyclization of (hetero)aryl cyclopropyl carbinols to form alpha-alkylidene-gamma-but

104 arbinol substituents determine the extent of cyclopropyl carbinyl cation formation.

105 TfOH then catalyzes the formation of cyclopropyl carbinyl cations, which undergo ring opening

106 ive charge located in the same region as the cyclopropyl carbinyl group; that S-thiolo-diphosphates o

107 The cyclopropyl carbinyl intermediate of the stepwise pathwa

108 The stabilization of the cyclopropyl carbinyl radical cation by substituents corr

109 urface, whereas unstabilized or destabilized cyclopropyl carbinyl radical cations are not minima on t

110 halo-Mannich-type reaction is reported using cyclopropyl carbonyl-derived enolates and sulfonyl-prote

111 3-(6-[([1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl) amino]-3-methyl-2-pyridinyl)-benzo

112 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methy l-2-pyridinyl]-benzo

113 The adenosine A2 receptor agonist 5'-(N-cyclopropyl)-carboxamidoadenosine (1 microM), although c

114 The intermediate cyclopropyl cation undergoes substantial ring opening si

115 ay crystallographic studies which showed the cyclopropyl chain to adopt very differing conformations

116 Both cyclopropyl compounds reduced putrescine and spermidine

117 dicated that the (S)- and (R)-isomers of the cyclopropyl-containing analogues were efficiently conver

118 e-metal-catalyzed process provides access to cyclopropyl-containing products and is achieved under en

119 lithiation-borylation reaction to attach the cyclopropyl-containing side chain.

120 We describe the synthesis of two cyclopropyl-containing tripeptide analogues, delta-(l-al

121 h an excess of LiCu(n-Bu)(2) to generate the cyclopropyl cuprate.

122 ds by palladium-catalyzed alpha-arylation of cyclopropyl, cyclobutyl and azetidinyl esters.

123 ft, whereas analog BT (1, 25-(OH)2-22-ene-24-cyclopropyl-D3), which binds to the vitamin D receptor w

124 as used for the asymmetric construction of a cyclopropyl-delta-lactone scaffold at a gram scale, whic

125 aches: a diphenyl C60 alcohol (5) based on a cyclopropyl derivative of Bingel and a diisopropyl cyclo

126 um parvum infections in vivo compared to the cyclopropyl derivative, which in turn is superior to the

127 acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which

128 gn approach, hydroxamates derived from trans-cyclopropyl dicarboxylate were examined as potential TNF

129 ing a cyclopropyl ring, 14,15-epoxy-[9,10,11-cyclopropyl]-eicosa-5Z,7E,13E-trienoic acid.

130 It was found that only the beta-cyclopropyl enantiomer 2a, but not the alpha-enantiomer

131 Synthesis of both the (1R,2R)- and (1S, 2S)-cyclopropyl enantiomers of the most potent racemic compo

132 The direct alpha-arylation of cyclopropyl esters and cyclobutyl esters is achieved in

133 sis of alkyl, alkenyl, aryl, heteroaryl, and cyclopropyl ethers, mixed O,O-acetals, and S,S,O-orthoes

134 Cyclopropyl fatty acids (about 0.1% of milk fat) were de

135 ienski olefination reagents 1-fluoropropyl, (cyclopropyl)fluoromethyl, 1-fluoro-2-methyl-2-propenyl,

136 discovery was the rational substitution of N-cyclopropyl for N-methoxy in 1a, a previously reported c

137 obutanone DA adducts to synthetically useful cyclopropyl functional handles is described.

138 panation yielded a library of N-O containing cyclopropyl-fused bicyclic intermediates.

139 the potential of this methodology for making cyclopropyl-fused heterocycles.

140 ion of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase

141 We report a facile approach to a cyclopropyl-fused pyrrolidine, which contains four stere

142 The enzymatically produced cyclopropyl-gamma-lactones can be further elaborated to

143 for the stereodivergent preparation of fused cyclopropyl-gamma-lactones of high value for medicinal c

144 romatography (LC) for LC/UVPD-MS analysis of cyclopropyl glycerophospholipids in Escherichia coli ( E

145 Our previous studies showed that N-(cyclopropyl)glycine (CPG) acts as a mechanism-based inac

146 The present study demonstrates that N-(cyclopropyl)glycine (CPG) is a mechanism-based inhibitor

147 Reactions proceeding through cyclopropyl gold(I) carbene-like intermediates are ideal

148 lectrophilic species with a highly distorted cyclopropyl gold(I) carbene-like structure, which can re

149 takes place stepwise, first by formation of cyclopropyl gold(I) carbenes, followed by a ring expansi

150 The key intermediates are cyclopropyl gold(I) carbenes, which have been independen

151 han related radicals that do not contain the cyclopropyl group (e.g., k = 1.1 x 10(6) s(-1) in CH3CN

152 ne group of 7 or inclusion of an olefinic or cyclopropyl group also reduced potency.

153 ond in position Delta9, 10, or 11 and Delta9 cyclopropyl group can activate TRPV1 with efficacy simil

154 ther cycloalkyls, the sp(2) character of the cyclopropyl group can confer improved H-bonding characte

155 ed that enantiomer 2a with a 11 beta,12 beta-cyclopropyl group exists as two populations of diastereo

156 Both the selective cleavage of the cyclopropyl group from the aromatic amine nitrogen and n

157 N-nitrosoaniline by specific cleavage of the cyclopropyl group from the nitrogen.

158 erically defined analogues of 7 containing a cyclopropyl group in place of the branched carbon were l

159 yclopropylanilines were designed to lock the cyclopropyl group into the required bisected conformatio

160 t contains a unique moiety in which a chiral cyclopropyl group is flanked by triene and enal chromoph

161 this deficiency and identify the fate of the cyclopropyl group lost upon N-dealkylation, we have inve

162 ylation only; no loss or ring-opening of the cyclopropyl group occurred.

163 ty of 3 seems to be interactions between the cyclopropyl group of 3 and the backbone of Phe495 and Me

164 ntramolecular abstraction of a beta-H of the cyclopropyl group to form either methane or mesitylene f

165 Our studies show that the cyclopropyl group undergoes reversible general-acid/base

166 Potency was enhanced with a 9-cyclopropyl group, the duration of action was improved w

167 D using a fatty aldehyde that incorporates a cyclopropyl group, which can act as a radical clock.

168 adical-stabilizing phenyl substituent on the cyclopropyl group.

169 uence trapping of nucleophiles by the A-ring cyclopropyl group.

170 efully consider the chirality of substituted cyclopropyl groups as radical reporting groups in studie

171 clude asymmetric substitution, olefinic, and cyclopropyl groups.

172 electrophiles, except allylic, benzylic, and cyclopropyl halides where single-electron-transfer proce

173 ubfamily of these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydr

174 Our results rely on the formation of cyclopropyl-I((III)) intermediates able to undergo elect

175 (1R,2R)-4-(2-(5,5-Dimethylhex-1-ynyl)cyclopropyl)imidazole (32) is one of the most potent his

176 nally, under peroxidatic conditions, 1a (R = cyclopropyl) inactivates HRP with concurrent formation o

177 conformational free energy landscape for the cyclopropyl inhibitors show a strong bias for the (4)H3

178 We demonstrate that tomato cyclopropyl isomerase (SlCPI), an enzyme involved in ste

179 Four new tetramines, the two cyclopropyl isomers, the trans-cyclobutyl isomer, and th

180 zed aldol addition reaction using a strained cyclopropyl ketenethioacetal, (2) an efficient enyne rin

181 ediated regioselective ring expansion of the cyclopropyl ketone.

182 Comparatively less active cyclopropyl ketones also follow a similar protocol if su

183 te HBr reagents in ring-opening reactions of cyclopropyl ketones as well as of 2,2-difluorocyclopropy

184 symmetric [3 + 2] photocycloaddition of aryl cyclopropyl ketones that enables the enantiocontrolled c

185 Using SnCl4 as the catalyst, alkenyl cyclopropyl ketones undergo ring-opening cyclization to

186 In contrast, the cyclopropyl ketones underwent homoconjugate addition wit

187 his reaction, ortho-disubstituted phenyl and cyclopropyl ketones were recognized as crucial structura

188 lyze the asymmetric [3 + 2] cycloaddition of cyclopropyl ketones with alkenes.

189 heteroaromatic, alpha,beta-unsaturated, and cyclopropyl ketones, affording high reactivity (up to 1,

190 nnel that instead leads to the corresponding cyclopropyl ketones.

191 f N-enoxyphthalimides to furnish substituted cyclopropyl-ketones.

192 of the allylic diazoesters 16a-d to give the cyclopropyl lactones 17a-d in high enantiomeric excess.

193 ne carboxylic acid 22 and the diastereomeric cyclopropyl lactones 32a,b featured diastereoselective i

194 es of the cyclopropane ring are observed for cyclopropyl lipids, resulting in diagnostic pairs of fra

195 Cyclopropyl malonoyl peroxide (1), which can be prepared

196 ethyl series are observed with a series of N-cyclopropyl mechanism based inactivators.

197 Solvolysis of 1-(trimethylsilylmethyl)cyclopropyl mesylate in CD(3)CO(2)D gives ring-opened pr

198 n of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)iso indolin-1-one

199 ions, provides exclusively the corresponding cyclopropyl methyl ketones.

200 N9-propyl and N9-cyclopropyl methyl substitutions did not afford further

201 substitutions (Me, Et, (n)()Pr, (i)()Pr, and cyclopropyl methyl) at the oxime moiety are preferred fo

202 oxy, as well as 2-pyridone-N-bearing methyl, cyclopropyl methyl, cyclopentyl methyl, benzyl, phenyl,

203 on-fluorination of n-propyl, 5-hexenyl, and (cyclopropyl)methyl PT-sulfones proceeded under homogeneo

204 lowed by analogues such as 7a, with an N-bis(cyclopropyl)methyl-N-propylamino side chain, and analogu

205 eceptor antagonist (NBI27914 [5-chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-tric

206 N1-ethyl-N11-[(cyclopropyl)methyl]-4,8,-diazaundecane (CPENSpm) is a po

207 e, the bromine was substituted to generate a cyclopropyl MIDA derivative.

208 the Ir(III)-tethered DNA assembly containing cyclopropyl-modified bases provides a unique model syste

209 Installation of a cyclopropyl moiety at either the 3,4- or 4,5-position of

210 The cyclopropyl moiety in (18)F-FCPHA does have a significan

211 This fatty acid, containing a cyclopropyl moiety in the beta,gamma-position, was desig

212 In addition, a cyclopropyl moiety incorporated into the linker and full

213 uggesting that the conjugative effect of the cyclopropyl moiety is minimal.

214 ered ether followed by addition of a further cyclopropyl moiety, affecting only one of the two bicycl

215 avine, a complex ergot alkaloid containing a cyclopropyl moiety.

216 of the chanoclavine-I intermediate to form a cyclopropyl moiety.

217 uption of and configurational changes in the cyclopropyl moiety; disruption, oxidation, and configura

218 ed the selective KCC2 inhibitor VU0463271 [N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyri

219 A group of N-cyclopropyl-N-alkylanilines has been synthesized, and th

220 Unexpectedly, N-benzyl-N-cyclopropyl-N-methylamine (4) was found not to inactivat

221 as been studied using the probe substrates N-cyclopropyl-N-methylaniline (2a) and N-(1'-methylcyclopr

222 Although the SET oxidation of N-cyclopropyl-N-methylaniline (3) by horseradish peroxidas

223 ion, we have investigated the oxidation of N-cyclopropyl-N-methylaniline (3) by horseradish peroxidas

224 N-Cyclopropyl-N-methylaniline (5) is a poor probe for sing

225 a), and application of mechanistic probes (N-cyclopropyl-N-methylaniline (CMA) and (p-methoxyphenyl)-

226 ling of sterically hindered beta-substituted cyclopropyl nitriles with a number of aryl groups and he

227 like the hydroxylated DENSPM compounds, both cyclopropyl norspermines substantially upregulated sperm

228 n, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid methyl ester and bryostatin 1

229 oits the energetics of such an intermediate, cyclopropyl-p-benzoquinone (CPBQ) is shown to be a speci

230 In the present study, a series of N-alkyl-N-cyclopropyl-p-chloroaniline probes have been used to exa

231 ided that the ethyl group always prefers the cyclopropyl position as in 3a, the 1-ethyl-5-methylsemib

232 xidase leads exclusively to ring-opened (non-cyclopropyl) products, P450 oxidation of 3 leads to form

233 lactone reduction and cyclization, afforded cyclopropyl pyran 1.

234 oaddition reactions of the synthesized spiro-cyclopropyl pyrazolones with phenyl isothiocyanate and b

235 tolerated in this reaction including vinyl, cyclopropyl, pyridyl, aryl, benzyl, and nitro groups.

236 odent parasite Plasmodium chabaudi with seco-cyclopropyl pyrrolo indole analogs.

237 ld also be attenuated by treatment with seco-cyclopropyl pyrrolo indole analogs.

238 Discussed herein is cyclopropyl quinone methide formation from a pyrido[1,2-

239 [Chemical structure: see text] A cyclopropyl quinone methide is formed by elimination of

240 icted electron affinities show that only the cyclopropyl radical tends to bind electrons among the hy

241 e electrocyclic ring-opening reaction of the cyclopropyl radical.

242 f 1,5-enyne substrates revealed an uncovered cyclopropyl rearrangement that gives rise to [3,6,5,7] t

243 R affinity, and those larger or smaller than cyclopropyl reduced A(1)AR selectivity.

244 The cyclopropyl reporter group imparts a 35-fold acceleratio

245 Consequently, the cyclopropyl ring addresses multiple roadblocks that can

246 itor of AdoHcy hydrolase not modified with a cyclopropyl ring at 6-amino group, also inhibited T. bru

247 a methyl group at the C1 position of the P1' cyclopropyl ring enhanced plasma trough values following

248 gical chlorination is a cryptic strategy for cyclopropyl ring formation.

249 m ion formed by SET oxidation of 3 undergoes cyclopropyl ring fragmentation exclusively to generate a

250 enzyme, CmaC, catalyses the formation of the cyclopropyl ring from the gamma-Cl-l-allo-isoleucine pro

251 substituent derived from the cleavage of the cyclopropyl ring in CPG.

252 tly, there has been an increasing use of the cyclopropyl ring in drug development to transition drug

253 onformationally restricted structures have a cyclopropyl ring in the interfacial region of the phosph

254 ion of optimal sulfur bond and adaptation of cyclopropyl ring in the S2'-subsite.

255 formed in the photolysis via opening of the cyclopropyl ring is 2-methyl-5-isopropylcyclopent-2-enon

256 e little-known chiroptical contribution of a cyclopropyl ring linked to polyene systems.

257 eview will focus on the contributions that a cyclopropyl ring makes to the properties of drugs contai

258 The inner cyclopropyl ring of 3 was assembled with trans geometry

259 ark apparatus, where the aldol condensation, cyclopropyl ring opening followed by cyclization took pl

260 ument the presence of general-acid-catalyzed cyclopropyl ring opening near neutrality and to assess t

261 This step is followed by rapid cyclopropyl ring opening to produce an iminium ion with

262 p undergoes C2 methylation in the absence of cyclopropyl ring opening, disfavoring mechanisms that in

263 hed ene and Diels-Alder products without any cyclopropyl ring opening, that of 3 carrying the ultrafa

264 radical clock afforded products derived from cyclopropyl ring opening.

265 arrangement of bicyclo-beta-ketoester having cyclopropyl ring to access fused tricyclic gamma-butyrol

266 followed by nucleophilic ring opening of the cyclopropyl ring to form desired tetrahydropyrrolo[1,2-a

267 m hydrolysis of a novel epoxide containing a cyclopropyl ring, 14,15-epoxy-[9,10,11-cyclopropyl]-eico

268 s known to undergo spontaneous, irreversible cyclopropyl ring-opening after an initial single-electro

269 t on the rate of nucleophile trapping by the cyclopropyl ring.

270 the enamine and the sigma*C-C orbital of the cyclopropyl ring.

271 the effect of substituents at both aryl and cyclopropyl rings.

272 ent conditions of 0.049 microM while the N-6-cyclopropyl-Sal-AMS 16 led to improved potency and to a

273 activity from the opposite enantiomer of the cyclopropyl scaffolds, which display almost superimposab

274 ew class of ligands is a 2-aminomethyl-trans-cyclopropyl side chain attached to a substituted benzene

275 esulted in cyclopropanation to form the anti-cyclopropyl silyl ether.

276 l-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available al

277 utational studies (B3LYP/6-31G) suggest that cyclopropyl stabilization of carbenes is more effective

278 cycloisomerase (EC ) to convert pentacyclic cyclopropyl sterols to conventional tetracyclic sterols.

279 studies and elucidating the in vivo roles of cyclopropyl sterols.

280 ogy model characterized distinct hydrophobic cyclopropyl subpockets, the larger "A" forming contacts

281 a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position.

282 ength of the straps connecting adjacent meso-cyclopropyl substituents decreases (the opposite of the

283 The resulting cyclopropyl substituted allenes derived from acyloxy mig

284 of highly functionalized cyclohexenones from cyclopropyl substituted propargyl esters.

285 The cyclopropyl-substituted alkynylcarbene complex Cp(CO)(2)

286 This is a general phenomenon and a number of cyclopropyl-substituted benzophenones, including 4-(endo

287 nthesis and biological evaluation of novel 4-cyclopropyl-substituted pyridothiadiazine dioxides was p

288 adical was observed, but, unlike other alpha-cyclopropyl-substituted radicals, this showed no propens

289 yl moiety of 6 and (2) hydroxyl, acetyl, and cyclopropyl substitutions on the butylamide linking chai

290 A cyclopropyl substrate analogue inactivates both enzymes

291 nes, and nitriles, forming the corresponding cyclopropyl sulfones under mild conditions in high yield

292 r 4 h gives a variety of (enantiopure) trans-cyclopropyl sulfones with high diastereoselectivity.

293 ugh a gold(I)-catalyzed alkoxycyclization of cyclopropyl-tethered 1,6-enynes.

294 ium salt of the tosylhydrazone derivative of cyclopropyl trimethylsilylmethyl ketone gave 1-cycloprop

295 We also showed that beta-cyclopropyl-Trp undergoes C2 methylation in the absence

296 that conformational strain induced through a cyclopropyl unit may add to the armory of tight-binding

297 inpoint the location of both double bond and cyclopropyl unsaturations on the four acyl chains of CLs

298 derived from carbonylative C-C activation of cyclopropyl ureas can be "captured" by pendant nucleophi

299 The order of stability of the cyclopropyl-X radicals was calculated to be X = CH2 >> X

300 The relative rate of ring opening for cyclopropyl-X radicals X = CH2 to X = O was calculated t