ライフサイエンスコーパス: cyclops

1 tants for the nodal-related genes squint and cyclops.

2 ase A rescues the phenotypes associated with cyclops.

3 Lotus japonicus and its ipd3 knockout mutant cyclops-4.

4 Second, we demonstrate that CYCLOPS, a method for inferring circadian time of collec

5 in combination with the transcription factor Cyclops and conferring gene expression during both AM an

6 mozygotes displays axial defects and reduced cyclops and mesodermal gene expression, and penetrance o

7 down embryos displayed reduced expression of cyclops and mesodermal genes, axial defects similar to N

8 2 are expressed in the left heart field; and cyclops and pitx2 are expressed in the left gut primordi

9 thway leads to zebrafish endoderm formation: Cyclops and Squint activate receptors such as TARAM-A; O

10 e also show that the Nodal-related molecules Cyclops and Squint and the transmembrane protein Oep are

11 ndoderm formation requires the Nodal signals Cyclops and Squint and their cofactor One-eyed pinhead (

12 The nodal-related genes cyclops and squint are expressed at the blastoderm margi

13 First, overexpression of cyclops and squint at different doses leads to the induc

14 that Bon functions exclusively downstream of cyclops and squint signaling.

15 Here we test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth

16 pression patterns of the nodal-related genes cyclops and squint.

17 In sum, these data show the power of CYCLOPS and temporal reconstruction in bridging basic ci

18 ator of symbiotic (transmitted via CCaMK and CYCLOPS) and hormonal (gibberellin) signals.

19 expression, including the Nodal-related gene cyclops, and body axis dorsalization.

20 is analysis places RAM1 downstream of CCaMK, CYCLOPS, and DELLA because ectopic expression of RAM1 re

21 ed in the early zebrafish embryo, squint and cyclops; antiSOX3c-injection leads to an increase in the

22 zebrafish Nodal-related proteins Squint and Cyclops are required in the YSL for endoderm and head me

23 se genes, and a second nodal-related factor, cyclops, are also expressed in the overlying marginal bl

24 The cyclops b16 mutation deletes ventral midline cells in th

25 Functional promoter studies revealed that CYCLOPS binds in a sequence-specific manner to a motif w

26 Whereas different levels of both Squint and Cyclops can induce different downstream genes, we find t

27 We concluded that the CCaMK/Cyclops complex can contribute to at least three distinc

28 onclude that the activation of ERN1 by CCaMK/CYCLOPS complex is an important step controlling IT-medi

29 These CYCLOPS (copy number alterations yielding cancer liabili

30 copy-number associated gene dependencies was CYCLOPS (Copy-number alterations Yielding Cancer Liabili

31 In the zebrafish mutant cyclops (Cyc(b16)), most embryos have two partial retina

32 wo Nodal-related proteins - Squint (Sqt) and Cyclops (Cyc) - are expressed during germ-layer specific

33 brafish nodal-related genes squint (sqt) and cyclops (cyc) [3] [4] [5], dorsal marginal cells adopt n

34 activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterni

35 e report that the zebrafish squint (sqt) and cyclops (cyc) genes have essential, although partly redu

36 Zebrafish cyclops (cyc) mutations cause deficiencies in the dorsal

37 loating head (flh, a Not homeobox gene), and cyclops (cyc) play direct and essential roles in the dev

38 ion is present in one-eyed pinhead (oep) and cyclops (cyc) zebrafish mutants, the pattern is altered.

39 acterized three gamma-ray induced alleles of cyclops (cyc), a gene required for development of midlin

40 ng boz, sqt and a second nodal-related gene, cyclops (cyc).

41 In cyclops (cyc-) mutants, which develop with a partial def

42 A cyclops-dependent midline domain, associated with the pr

43 However, in squint;cyclops double mutants, which lack Nodal function and po

44 cyclops embryos showed essentially normal Lim3 expressio

45 From this structure, CYCLOPS estimates the phase of each sample.

46 autoregulation, whereas other factors induce cyclops expression in ventrolateral cells.

47 ced Foxd3 function results in a reduction of cyclops expression, and subsequent mesodermal and axial

48 jection leads to an increase in the level of cyclops expression.

49 cts left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm.

50 oderm require different levels of squint and cyclops function.

51 We validated SF3B1 as a CYCLOPS gene and found that human cancer cells harboring

52 Wild-type cyclops gene function is required for these morphogeneti

53 Differential regulation of the cyclops gene in these cells contributes to the different

54 One CYCLOPS gene, PSMC2, encodes an essential member of the

55 f a point source of Nodal ligands Squint and Cyclops in a non-cell autonomous manner.

56 lso investigate the potential involvement of cyclops in the hh signaling pathway and conclude that al

57 ealthy cyclops leaf-nosed bats (Hipposideros cyclops) in Uganda.

58 on in the symbiosis signaling pathway mutant cyclops/ipd3, indicating an intersection between DELLA a

59 tivity range of the short-range Nodal signal Cyclops is not regulated by Lefty activity.

60 such as sonic hedgehog and one-eyed-pinhead, cyclops is required for ventral midline patterning of th

61 as far back as ancient literature (e.g., the Cyclops Islands in The Odyssey, 850 BCE).

62 bella virus, was found in apparently healthy cyclops leaf-nosed bats (Hipposideros cyclops) in Uganda

63 tx2, ectopic pitx2c in other regions induces cyclops, lefty2 and goosecoid expression.

64 itx2 are expressed in the left diencephalon; cyclops, lefty2 and pitx2 are expressed in the left hear

65 embryos, L-R asymmetric expression of Nodal/cyclops, Lefty2/antivin, and Pitx2 does not occur in the

66 Here, we report that the cyclops locus encodes the nodal-related protein Ndr2, a

67 he brain, including the previously described cyclops locus.

68 However, CYCLOPS magnitude, a measure of global rhythm strength,

69 In embryos lacking both squint and cyclops, members of the nodal group of TGF-beta related

70 We conclude that these observations in the cyclops mutant are compatible with mechanisms of pattern

71 signaling pathway and conclude that although cyclops mutant cells can respond to hh signaling, neithe

72 m3 expression in no tail, floating head, and cyclops mutant embryos, all of which have midline defect

73 sion of RAM1 restores arbuscule formation in cyclops mutants and in the presence of suppressive gibbe

74 y the Nodal pathway, behave normal in squint;cyclops mutants but exhibit defective motility in one-ey

75 f dorsal mesendoderm induction in squint and cyclops mutants suggests that dorsal marginal cells can

76 omite and optic stalk defects in no tail and cyclops mutants that lack midline structures that normal

77 In cyclops mutants, corresponding cells failed to move ante

78 The cyclops mutation leads to a loss of medial floor plate a

79 e downstream transcription factors including CYCLOPS, NIN, and ERN1 were not required for this respon

80 of pitx2c midline expression is dependent on cyclops (nodal) and schmalspur, but not no tail (brachyu

81 cyclops (nodal), lefty1 and pitx2 are expressed in the l

82 nes implicated in laterality of the viscera (cyclops/nodal, antivin/lefty and pitx2) are coexpressed

83 in oep eliminate the response to Squint and Cyclops overexpression but are suppressed by expression

84 on in the initiation codon and rescue of the cyclops phenotype by expression of ndr2 RNA, here rename

85 ygotes or hypomorphic alleles) results in a 'cyclops' phenotype, where mid-dorsal head epidermis is t

86 ided expression domains of downstream genes (cyclops, pitx2, lefty1 and lefty2) are severely downregu

87 In contrast, while Znr1/Cyclops reproducibly induces mesodermal and neural marke

88 Dorsal expression of cyclops requires Nodal-dependent autoregulation, whereas

89 ntified zebrafish nodal-related factor, Znr1/Cyclops, reveals distinct inductive properties of each l

90 echnologies Group AQUAtracka, Turner Designs Cyclops, Satlantic SUNA and WET Labs, Inc.

91 sis demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm pat

92 ch as those mutated in the zebrafish mutants cyclops, squint and one-eyed pinhead (oep), cause HPE.

93 deficient embryos (Antivin overexpressing or cyclops;squint double mutants), which show extensive AP

94 ted with reduced wnt8 expression, as seen in cyclops;squint mutants.

95 almodulin-dependent protein kinase-activated CYCLOPS, through the AMCYC-RE in their promoter, and DEL

96 ype by expression of ndr2 RNA, here renamed "cyclops." Thus, in interaction with other molecules impl

97 hat activates RAM1 expression via binding of CYCLOPS to a cis element in the RAM1 promoter.

98 th NODULATION SIGNALING PATHWAY 2 (NSP2) and CYCLOPS to repress the transcription of NODULE INCEPTION

99 wo zebrafish nodal-related genes, squint and cyclops, to manipulate genetically the levels and timing

100 in reduction is suppressed in bozozok;squint;cyclops triple mutants, and is associated with reduced w

101 ithm, cyclic ordering by periodic structure (CYCLOPS), uses evolutionary conservation and machine lea

102 We validated CYCLOPS using temporally ordered mouse and human data an