ライフサイエンスコーパス: cystathionine

1 lation or the appearance of homocysteine and cystathionine.

2 densation of serine and homocysteine to form cystathionine.

3 t condensation of serine and homocysteine to cystathionine.

4 eine, ribosylhomocysteine, homocysteine, and cystathionine.

5 densation of homocysteine and serine to form cystathionine.

6 cysteine and O-acetylserine (OAS) to produce cystathionine.

7 74F substitution, allowing better access for cystathionine.

8 up analyses showed that the relation between cystathionine and all-cause mortality in SAP patients wa

9 n the classic AMC) and thence by CysK(Hp) to cystathionine and by MetB(Hp) to cysteine.

10 f homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.

11 and methionine and reduced concentrations of cystathionine and cysteine.

12 re was a positive association between plasma cystathionine and death (age- and sex-adjusted HRs [95%

13 ysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, resp

14 S(Hp) mutant was restored by homocysteine or cystathionine and growth of the DeltacysK(Hp) mutant by

15 mocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.

16 inhibited the gamma-elimination reaction of cystathionine and H(2)S synthesis from cysteine by human

17 ensation of serine and homocysteine to yield cystathionine and is the single most common locus of mut

18 Macrophages were pretreated with L-cystathionine and then treated with ox-LDL.

19 r serine or cysteine by homocysteine to give cystathionine and water or H(2)S, respectively.

20 ay, one-carbon metabolism, transsulfuration (cystathionine), and glycine decarboxylation (serine and

21 Here we identify cystathionine B-synthase a (cbsa), which encodes the key

22 s endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamm

23 Mutations in the human cystathionine beta synthase (CBS) gene are known to caus

24 alysis using CytoNCA on the data sets showed cystathionine beta synthase and methylmalonyl-CoA-mutase

25 Five-month-old cystathionine beta synthase heterozygous and wild-type C

26 and GADD153 in ethanol-treated heterozygous cystathionine beta synthase mice.

27 yielded variant ALR(Y274F), which catalyzes cystathionine beta-elimination with a near-native Michae

28 oli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL).

29 nate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensit

30 and hypercholesterolemia in which the mouse cystathionine beta-synthase (CBS) and apolipoprotein E (

31 In vertebrates, cystathionine beta-synthase (CBS) and cystathionine gamm

32 es involved in the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

33 wo enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

34 synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamm

35 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase (CBS) and gamma-cystathionas

36 Hcy and hyperlipidemia mouse model, in which cystathionine beta-synthase (CBS) and low-density lipopr

37 O-acetylserine sulfhydrylase (OASS) and cystathionine beta-synthase (CBS) are members of the PLP

38 Cystathionine beta-synthase (CBS) catalyzes the condensa

39 Cystathionine beta-synthase (CBS) catalyzes the first ir

40 Cystathionine beta-synthase (CBS) condenses homocysteine

41 Cystathionine beta-synthase (CBS) contains a prosthetic

42 Cystathionine beta-synthase (CBS) controls the flux of s

43 Untreated cystathionine beta-synthase (CBS) deficiency in humans i

44 Cystathionine beta-synthase (CBS) deficiency is a recess

45 Cystathionine beta-synthase (CBS) deficiency, a genetic

46 e setting of hyperhomocysteinemia because of cystathionine beta-synthase (CBS) deficiency, an inborn

47 Homocystinuria, which typically results from cystathionine beta-synthase (CBS) deficiency, is the mos

48 mon cause of many genetic diseases including cystathionine beta-synthase (CBS) deficiency.

49 e (Hcy) in plasma and tissues resulting from cystathionine beta-synthase (CBS) deficiency.

50 e of CNNM2 (CNNM2BAT), which consists of two cystathionine beta-synthase (CBS) domains (IPR000664) an

51 Cytoplasmic cystathionine beta-synthase (CBS) domains are strategica

52 rous proteins containing pairs of regulatory cystathionine beta-synthase (CBS) domains, family II pyr

53 cleotide-binding insert comprising a pair of cystathionine beta-synthase (CBS) domains, termed a Bate

54 Deficiencies of the human cystathionine beta-synthase (CBS) enzyme are characteriz

55 serine hydroxymethyltransferase (SHMT), and cystathionine beta-synthase (CBS) genes and their associ

56 Cystathionine beta-synthase (CBS) is a heme-dependent an

57 Cystathionine beta-synthase (CBS) is a key enzyme in hum

58 Cystathionine beta-synthase (CBS) is a key enzyme in sul

59 Cystathionine beta-synthase (CBS) is a pyridoxal phospha

60 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-depe

61 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phos

62 Cystathionine beta-synthase (CBS) is a tetrameric heme p

63 Human cystathionine beta-synthase (CBS) is a unique pyridoxal

64 Cystathionine beta-synthase (CBS) is an essential pyrido

65 Cystathionine beta-synthase (CBS) is the first and rate-

66 omocysteinemia due to genetic alterations in cystathionine beta-synthase (Cbs) or methylenetetrahydro

67 dition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydro

68 Cystathionine beta-synthase (CBS) plays a central role i

69 nism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/

70 mice deficient in the H(2)S-producing enzyme cystathionine beta-synthase (CBS) survive longer with re

71 Wild-type and cystathionine beta-synthase (CBS)(+/-) HHcy mice were tr

72 Cystathionine beta-synthase (CBS), a key enzyme in the m

73 Human cystathionine beta-synthase (CBS), a novel heme-containi

74 ine clearance converge at the active site of cystathionine beta-synthase (CBS), a pyridoxal phosphate

75 Patients with homocystinuria lack the enzyme cystathionine beta-synthase (CBS), and many of these ind

76 gen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma l

77 d metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accum

78 mitting step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to c

79 Cystathionine beta-synthase (CBS)-deficient patients are

80 On a hyperhomocysteinemic diet, cystathionine beta-synthase (Cbs)-heterozygous mice deve

81 ted by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).

82 omocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).

83 ionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).

84 ound a single nucleotide polymorphism within cystathionine beta-synthase (CYS4) that causes multi-dru

85 Here we show that Drosophila cystathionine beta-synthase (dCBS), which catalyzes the

86 zMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable fo

87 ons from the models, mutation of residues in cystathionine beta-synthase and channel domains either a

88 hide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyas

89 oduced endogenously by catalytic activity of cystathionine beta-synthase and cystathionine gamma-lyas

90 Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyas

91 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyas

92 se of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyas

93 the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE

94 of MST versus the other two H2S generators, cystathionine beta-synthase and gamma-cystathionase, has

95 es the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase and gamma-cystathionase, whe

96 the other enzymes involved either directly (cystathionine beta-synthase and mercaptopyruvate sulfurt

97 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the

98 Cystathionine beta-synthase catalyzes the condensation o

99 oprotection, its chronic increase such as in cystathionine beta-synthase deficiency may pose a proble

100 WT and Cystathionine beta-Synthase deficient (CBS+/-) mice repr

101 n (SIS), biofilm-related region 2 (B2) and a cystathionine beta-synthase domain pair (CBS).

102 e and stability of PAE2072, a dimeric tandem cystathionine beta-synthase domain protein from the hype

103 ontain a sugar isomerase domain and a tandem cystathionine beta-synthase domain.

104 Cystathionine beta-synthase domains are found in a myria

105 -phosphate isomerases but lacking the tandem cystathionine beta-synthase domains found in the other a

106 eep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamid

107 entified KINgamma, a protein containing four cystathionine beta-synthase domains, as an interacting p

108 rase domain of E. coli KdsD, lacking the two cystathionine beta-synthase domains, demonstrated API ac

109 e potential ATP binding by the intracellular cystathionine beta-synthase domains.

110 300 million years ago in a proto-reptile by cystathionine beta-synthase duplication, cysteine lyase

111 No changes were observed in cystathionine beta-synthase expression, immunolocalized

112 eterozygous for a targeted disruption of the cystathionine beta-synthase gene (Cbs+/-) and wild-type

113 s in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively.

114 it was reversed by the inhibition of either cystathionine beta-synthase or cystathionine gamma-lyase

115 Here we express a mutant form of the human cystathionine beta-synthase protein, I278T, in Saccharom

116 Cystathionine beta-synthase regulates endothelial functi

117 xample of mutations in the catalytic core of cystathionine beta-synthase that result in failure of Ad

118 oderate (88 micromol/L) HHcy were induced in cystathionine beta-synthase wild-type (Cbs(+/+)) and het

119 Expression of cystathionine beta-synthase, a key gene in the transsulf

120 osome binding site of the cbs gene, encoding cystathionine beta-synthase, an enzyme that is a part of

121 we demonstrate that inactivation of putative cystathionine beta-synthase, cystathionine gamma-lyase,

122 These include cystathionine beta-synthase, cystathionine-gamma-lyase,

123 OR1 induction resulted in down-regulation of Cystathionine beta-synthase, which is known to lead to i

124 h-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient

125 Cystathionine beta-synthase-deficient homocystinuria (HC

126 Classical cystathionine beta-synthase-deficient homocystinuria (HC

127 The lean phenotype of cystathionine beta-synthase-deficient homocystinuria and

128 g-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.

129 einylation impairs collagen cross-linking in cystathionine beta-synthase-deficient mice: a novel mech

130 In hyperhomocysteinemic human cells and cystathionine beta-synthase-deficient mouse brains, we f

131 PON1 affects plasma N-Hcy-protein levels in cystathionine beta-synthase-deficient patients (n=28).

132 wed little or no CSE protein but did express cystathionine beta-synthase.

133 expression of cystathionine gamma-lyase and cystathionine beta-synthase.

134 ydrogen sulfide is recycled into cysteine by cystathionine beta-synthase.

135 ation of a full-length dimeric form of human cystathionine beta-synthase.

136 ogenous hydrogen sulfide synthesizing enzyme cystathionine beta-synthetase (CBS) in sensitization of

137 approximately 150 muM), which was induced in cystathionine-beta synthase heterozygous mice fed a high

138 rreversible cystathionine-gamma-synthase and cystathionine-beta-lyase enzymes.

139 C57BL/6J (wild-type) and cystathionine-beta-synthase (CBS(+/-)) mice, treated wit

140 emic mice deficient in the Cbs gene encoding cystathionine-beta-synthase (Cbs(+/-)) to evaluate retin

141 The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrog

142 ort in DS cells is due to high expression of cystathionine-beta-synthase (CBS) and subsequent overpro

143 Cystathionine-beta-synthase (CBS) deficiency is a human

144 Individuals with homozygous deficiency in cystathionine-beta-synthase (CBS) develop high levels of

145 e, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 s

146 requires ATP, which binds to the C-terminal cystathionine-beta-synthase (CBS) domain of SpoIVFB.

147 PR) includes a unique structure known as the cystathionine-beta-synthase (CBS) domain, though the rol

148 Tandem cystathionine-beta-synthase (CBS) domains in the ATP-bin

149 to the transmembrane part or to cytoplasmic cystathionine-beta-synthase (CBS) domains of ClC-7.

150 ficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal di

151 ve up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resul

152 e-homocysteine methyltransferase (Bhmt), and cystathionine-beta-synthase (Cbs) were up-regulated, but

153 Mice deficient in cystathionine-beta-synthase (cbs) were used as a model o

154 of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for e

155 thionine adenosyltransferase 1alpha (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofo

156 ntracellular carboxy-terminus containing two cystathionine-beta-synthase (CBS1 and CBS2) domains.

157 yperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-m

158 onine synthase reductase (MTRR) 66A-->G, and cystathionine-beta-synthase 844ins68.

159 ysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyas

160 Interestingly, both enzymes contain a cystathionine-beta-synthase domain (CBS).

161 rt or deletion of the last 11 amino acids of cystathionine-beta-synthase domain 1 gives rise to funct

162 zed domain of unknown function (DUF21) and a cystathionine-beta-synthase domain.

163 d large cytoplasmic C-termini containing two cystathionine-beta-synthase domains (CBS1 and CBS2) that

164 A mouse model of HHcy, in which cystathionine-beta-synthase is deficient (cbs (-/-)), wa

165 s proposed in which mutagenesis is driven by cystathionine-beta-synthase overexpression and altered f

166 that ox-LDL treatment down-regulated the H2S/cystathionine-beta-synthase pathway, with increased MCP-

167 Among these are CP12-CBS (for cystathionine-beta-synthase) domain fusions.

168 ism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxide dismutase) as po

169 ression of the gene, designated M truncatula Cystathionine-beta-Synthase-like1 (MtCBS1), using a prom

170 ate in the predicted pathways for serine and cystathionine biosynthesis.

171 nthesis from cysteine, but not the canonical cystathionine cleavage reaction catalyzed by CSE in vitr

172 se both serine and O-acetylserine to produce cystathionine, converting these substrates to an aminoac

173 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in T

174 bosylhomocysteine, homocysteine, methionine, cystathionine, cysteine, and homoserine were quantified

175 oline, phosphocholine, glyceophosphocholine, cystathionine, cysteine, hydrogen sulfide, glutathione d

176 nosylmethionine, S-adenosylhomocysteine, and cystathionine exhibited non-monotonic dose-dependent res

177 The K Ms for cystathionine for both pathogenic mutants are comparable

178 rom the methionine cycle provides sulfur for cystathionine formation, which may subsequently be used

179 In the reverse direction, CBS reacted with cystathionine, forming the aminoacrylate intermediate wi

180 P) cofactor which catalyzes the synthesis of cystathionine from homocysteine and serine.

181 , namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate s

182 ine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.

183 ndothelial cells, cysteine metabolism by the cystathionine gamma lyase (CSE), generates hydrogen sulf

184 H(2)S by cardiac-specific overexpression of cystathionine gamma-lyase (alpha-MHC-CGL-Tg mouse) signi

185 Cardiomyocyte-specific overexpression of cystathionine gamma-lyase (an enzyme that produces H(2)S

186 cysteine, alpha-ketobutyrate and ammonia by cystathionine gamma-lyase (CGL) in the reverse transsulf

187 of the transsulfuration pathway (TSP) enzyme cystathionine gamma-lyase (CGL), resulting in increased

188 onia and alpha-ketobutyrate by the action of cystathionine gamma-lyase (CGL).

189 nzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).

190 rived vasodilator, is produced by the enzyme cystathionine gamma-lyase (CSE) and acts by hyperpolariz

191 Cystathionine gamma-lyase (CSE) and cystathionine beta-s

192 rates, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are enzymes that catalys

193 on and activity of the H2S-generating enzyme cystathionine gamma-lyase (CSE) by promoting its transla

194 Cystathionine gamma-lyase (CSE) catalyzes H(2)S synthesi

195 ect enzymatically produced H2S from isolated cystathionine gamma-lyase (CSE) enzymes (p < 0.001) and

196 d that mice lacking the H2S-producing enzyme cystathionine gamma-lyase (CSE) exhibit elevated oxidati

197 of hydrogen sulfide (H(2)S) by inhibition of cystathionine gamma-lyase (CSE) increases sFlt-1 and sol

198 Cystathionine gamma-lyase (CSE) is a major H(2)S-produci

199 Cystathionine gamma-lyase (CSE) is one of the major enzy

200 Cystathionine gamma-lyase (CSE) produces H2S via enzymat

201 Cystathionine gamma-lyase (CSE) produces hydrogen sulfid

202 The expression of cystathionine gamma-lyase (CSE), a major H(2)S producing

203 Both H2S production and cystathionine gamma-lyase (CSE), an H2S enzyme, levels w

204 e of O2 sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H2S-generating enzym

205 thway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chie

206 since mice lacking its biosynthetic enzyme, cystathionine gamma-lyase (CSE), display pronounced hype

207 thway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), H2S has been implicated

208 H2S), a gaseous messenger produced mainly by cystathionine gamma-lyase (CSE), is a proangiogenic vaso

209 Here we show a major depletion of cystathionine gamma-lyase (CSE), the biosynthetic enzyme

210 Experiments with several blockers of cystathionine gamma-lyase (CSE), the enzyme responsible

211 ne K(M) and V(max) for natural substrates of cystathionine gamma-lyase (CSE), the main enzyme respons

212 rom ischemia/reperfusion injury, but whether cystathionine gamma-lyase (CSE), which produces endogeno

213 Using cystathionine gamma-lyase (CSE)-deficient mice, we demon

214 activity of cystathionine beta-synthase and cystathionine gamma-lyase (CSE).

215 of the trans-sulfuration pathway, including cystathionine gamma-lyase (CSE).

216 d by hydrogen sulfide (H(2)S) synthesized by cystathionine gamma-lyase (CSE).

217 way enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE).

218 treatment with Na2S or by overexpression of cystathionine gamma-lyase (CSE).

219 Cystathionine gamma-lyase (CSE; also cystathionase), a p

220 beta-elimination product of MSC catalyzed by cystathionine gamma-lyase (gamma-cystathionase).

221 A recombinant putative cystathionine gamma-lyase (smCSE) mineralizes CdS from a

222 atio and lower cystathione beta-synthase and cystathionine gamma-lyase activity.

223 ls to make H(2)S via increased expression of cystathionine gamma-lyase and cystathionine beta-synthas

224 bited transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.

225 s the transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.

226 Inhibition of cystathionine gamma-lyase causes rapid necrosis of TR/GR

227 Cystathionine gamma-lyase deficiency aggravates obesity-

228 genous expression of various KAT enzymes and cystathionine gamma-lyase present in target tissue coupl

229 Deletion of the CYS3 gene encoding cystathionine gamma-lyase resulted in the highest resist

230 evented by propargylglycine, an inhibitor of cystathionine gamma-lyase that catalyzes H(2)S formation

231 Expression of Bhmt and cystathionine gamma-lyase was decreased when mice were f

232 uation, immunohistochemistry (nitrotyrosine, cystathionine gamma-lyase, activated caspase-3, and extr

233 l content of cystathionine beta-synthase and cystathionine gamma-lyase, hydrogen sulfide-generating e

234 ion of putative cystathionine beta-synthase, cystathionine gamma-lyase, or 3-mercaptopyruvate sulfurt

235 ation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfu

236 ps involving cystathionine beta-synthase and cystathionine gamma-lyase.

237 ion of either cystathionine beta-synthase or cystathionine gamma-lyase.

238 s of peptidases, glutamate dehydrogenase and cystathionine gamma-lyase.

239 i) seeds with lower transcript expression of CYSTATHIONINE gamma-SYNTHASE (AtCGS), Met's main regulat

240 duces O-phospho-l-homoserine (HserP) used by cystathionine gamma-synthase (CGS) for Met synthesis and

241 cuous cleavage of O-succinyl-L-homoserine by cystathionine gamma-synthase (MetB).

242 e Bacillus subtilis metI gene, which encodes cystathionine gamma-synthase, regulate the expression of

243 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosph

244 1,25(OH)(2)D(3) also caused cystathionine-gamma-lyase (CSE) activation and H(2)S for

245 sent study aimed to identify the presence of cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate s

246 Inhibition of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-s

247 overexpression of the H(2)S-producing enzyme cystathionine-gamma-lyase (CSE) attenuated the hyperglyc

248 e in vascular beds, and its synthetic enzyme cystathionine-gamma-lyase (CSE) is down-regulated in gro

249 Cystathionine-gamma-lyase (CSE) is the predominant endot

250 etic ablation of the H2S-synthesizing enzyme cystathionine-gamma-lyase (CSE) normalized breathing in

251 The H2S-producing enzyme cystathionine-gamma-lyase (CSE) was expressed in both ne

252 7 and propargylglycin (PAG), an inhibitor of cystathionine-gamma-lyase (CSE), a key enzyme that produ

253 hydrogen sulphide (H2S)-synthesizing enzyme cystathionine-gamma-lyase (CSE).

254 abolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-lyase (CSE).

255 This study investigated the activities of cystathionine-gamma-lyase (CSE, the enzyme that catalyze

256 t-degrading enzymes, we engineered the human cystathionine-gamma-lyase (hMGL-4.0) to catalyze the sel

257 In contrast to CBS, silencing of cystathionine-gamma-lyase (the expression of which was u

258 ocker, 1 mg/kg) or dl-propargylglycine (PAG, Cystathionine-gamma-lyase [CSE, H(2)S-producing enzyme]

259 ely, silencing of the H(2)S-producing enzyme cystathionine-gamma-lyase abolishes NO-stimulated cGMP a

260 responsible for endogenous H2 S production, cystathionine-gamma-lyase and 3-mercaptopyruvate sulphur

261 the carotid body requires the interaction of cystathionine-gamma-lyase with haem oxygenase-2, which g

262 These include cystathionine beta-synthase, cystathionine-gamma-lyase, paraxonase 1, 5,10-methylenet

263 e carotid body, express haem oxygenase-2 and cystathionine-gamma-lyase, the enzymes which catalyse th

264 ation with a cystathionine-beta-synthase and cystathionine-gamma-lyase.

265 hese reactions are catalyzed by irreversible cystathionine-gamma-synthase and cystathionine-beta-lyas

266 ds expressing a feedback-insensitive form of CYSTATHIONINE-gamma-SYNTHASE, a key enzyme of Met synthe

267 his study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammat

268 tabolites S-adenosylmethionine, betaine, and cystathionine in MS gray matter.

269 omocysteine in the DeltacysK(Hp) mutant, and cystathionine in the DeltametB(Hp) mutant.

270 t condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a h

271 Elevated plasma cystathionine is associated with both cardiovascular and

272 and cell-culture models, we have found that cystathionine is capable of blocking the induction of he

273 In mammals, cystathionine is formed as an intermediate of the transs

274 Cystathionine is subsequently converted to cysteine plus

275 of the first of two enzymes in this pathway, cystathionine, is present at higher levels in brain as c

276 Elevated circulating cystathionine levels are related to atherosclerotic card

277 ysis indicate that the protective effects of cystathionine occur without any obvious alteration of th

278 ne and growth of the DeltacysK(Hp) mutant by cystathionine only.

279 Currently there is no known function for cystathionine other than serving as an intermediate in t

280 c acid (P<0.01-0.04), homocysteine (P<0.01), cystathionine (P<0.01), and the decreased S-adenosylmeth

281 e from serine, and rates of homocysteine and cystathionine production were assessed.

282 Cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocystei

283 he ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of

284 t enzymes involved in L-cysteine metabolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-

285 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear tra

286 experimental evidence that the abolition of cystathionine synthesis may contribute to the pathology

287 he possible contribution of the abolition of cystathionine synthesis to pathogenesis in HCU has not b

288 ine-synthesis reaction than in the canonical cystathionine-synthesis reaction.

289 CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.

290 regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesi

291 ion of homocysteine into Dha formed a stable cystathionine (thioether) analogue of the complement inh

292 This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2

293 1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S p

294 ha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic acid, glutamine,

295 We investigated whether plasma cystathionine was associated with mortality in patients

296 95% CIs per SD increment of log-transformed cystathionine were calculated using Cox regression model

297 homoserine via its sulfhydryl group to form cystathionine, which is cleaved to yield homocysteine.

298 tion of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, alp

299 The joint risk associations of high plasma cystathionine with lifestyle factors and impaired vitami

300 CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, py