ライフサイエンスコーパス: cystathionine beta-synthase

1 ation of a full-length dimeric form of human cystathionine beta-synthase.

2 hanism for the tissue specific regulation of cystathionine beta-synthase.

3 and indispensable role in the regulation of cystathionine beta-synthase.

4 ine management, methionine synthase (MS) and cystathionine beta-synthase.

5 ndent beta-replacement reaction catalyzed by cystathionine beta-synthase.

6 ne in Escherichia coli and of purified yeast cystathionine beta-synthase.

7 n architecture of the heme-independent yeast cystathionine beta-synthase.

8 igands as cysteinate and imidazole in ferric cystathionine beta-synthase.

9 nce of heme, which is found in human and rat cystathionine beta-synthase.

10 e first characterization of the PLP bound to cystathionine beta-synthase.

11 y half of the sites activity associated with cystathionine beta-synthase.

12 or homocystinuria is inherited disorders in cystathionine beta-synthase.

13 te reductase reaction and as an activator of cystathionine beta-synthase.

14 wed little or no CSE protein but did express cystathionine beta-synthase.

15 expression of cystathionine gamma-lyase and cystathionine beta-synthase.

16 ydrogen sulfide is recycled into cysteine by cystathionine beta-synthase.

17 f genes localized to chromosome 21 including cystathionine-beta-synthase.

18 onine synthase reductase (MTRR) 66A-->G, and cystathionine-beta-synthase 844ins68.

19 Expression of cystathionine beta-synthase, a key gene in the transsulf

20 Cystathionine beta-synthase activity is also regulated i

21 zMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable fo

22 heme, and is accompanied by complete loss of cystathionine beta-synthase activity.

23 osome binding site of the cbs gene, encoding cystathionine beta-synthase, an enzyme that is a part of

24 alysis using CytoNCA on the data sets showed cystathionine beta synthase and methylmalonyl-CoA-mutase

25 esizing enzymes - cystathionine gamma-lyase, cystathionine beta-synthase and 3-mercaptosulfotransfera

26 ons from the models, mutation of residues in cystathionine beta-synthase and channel domains either a

27 se of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyas

28 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyas

29 hide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyas

30 oduced endogenously by catalytic activity of cystathionine beta-synthase and cystathionine gamma-lyas

31 Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyas

32 the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE

33 of MST versus the other two H2S generators, cystathionine beta-synthase and gamma-cystathionase, has

34 es the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase and gamma-cystathionase, whe

35 the other enzymes involved either directly (cystathionine beta-synthase and mercaptopyruvate sulfurt

36 ish the overall catalytic mechanism of yeast cystathionine beta-synthase and provide a useful system

37 ysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyas

38 In contrast, transcripts of cystathionine-beta-synthase and deoxycytidine kinase wer

39 enotype of other folate-related genes (e.g., cystathionine-beta-synthase and methionine synthase redu

40 h-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient

41 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the

42 he conclusion that the heme and PLP sites in cystathionine beta-synthase are nonequivalent.

43 uishable states that are observed with human cystathionine beta-synthase: "basal" (i.e., wild-type en

44 omocystinuria as a result of a deficiency of cystathionine beta-synthase can be prevented by the scre

45 Cystathionine beta-synthase catalyzes the condensation o

46 Human cystathionine beta-synthase catalyzes the first step in

47 s endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamm

48 Mutations in the human cystathionine beta synthase (CBS) gene are known to caus

49 Human cystathionine beta--synthase (CBS) is an S-adenosylmethi

50 , methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair in

51 We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (

52 nate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensit

53 and hypercholesterolemia in which the mouse cystathionine beta-synthase (CBS) and apolipoprotein E (

54 wo enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

55 synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamm

56 In vertebrates, cystathionine beta-synthase (CBS) and cystathionine gamm

57 es involved in the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

58 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase (CBS) and gamma-cystathionas

59 Hcy and hyperlipidemia mouse model, in which cystathionine beta-synthase (CBS) and low-density lipopr

60 Mutations in cystathionine beta-synthase (CBS) are known to cause hom

61 O-acetylserine sulfhydrylase (OASS) and cystathionine beta-synthase (CBS) are members of the PLP

62 Cystathionine beta-synthase (CBS) catalyzes the committi

63 Cystathionine beta-synthase (CBS) catalyzes the condensa

64 Cystathionine beta-synthase (CBS) catalyzes the condensa

65 Cystathionine beta-synthase (CBS) catalyzes the condensa

66 Cystathionine beta-synthase (CBS) catalyzes the first ir

67 Cystathionine beta-synthase (CBS) catalyzes the first of

68 etabolism resulting from loss of function in cystathionine beta-synthase (CBS) cause classic homocyst

69 Cystathionine beta-synthase (CBS) condenses homocysteine

70 Cystathionine beta-synthase (CBS) contains a prosthetic

71 Cystathionine beta-synthase (CBS) controls the flux of s

72 Untreated cystathionine beta-synthase (CBS) deficiency in humans i

73 Cystathionine beta-synthase (CBS) deficiency is a recess

74 Cystathionine beta-synthase (CBS) deficiency is a recess

75 Cystathionine beta-synthase (CBS) deficiency is an autos

76 Cystathionine beta-synthase (CBS) deficiency, a genetic

77 e setting of hyperhomocysteinemia because of cystathionine beta-synthase (CBS) deficiency, an inborn

78 Homocystinuria, which typically results from cystathionine beta-synthase (CBS) deficiency, is the mos

79 e (Hcy) in plasma and tissues resulting from cystathionine beta-synthase (CBS) deficiency.

80 mon cause of many genetic diseases including cystathionine beta-synthase (CBS) deficiency.

81 e of CNNM2 (CNNM2BAT), which consists of two cystathionine beta-synthase (CBS) domains (IPR000664) an

82 Cytoplasmic cystathionine beta-synthase (CBS) domains are strategica

83 rous proteins containing pairs of regulatory cystathionine beta-synthase (CBS) domains, family II pyr

84 cleotide-binding insert comprising a pair of cystathionine beta-synthase (CBS) domains, termed a Bate

85 Cystathionine beta-synthase (CBS) effects the condensati

86 Deficiencies of the human cystathionine beta-synthase (CBS) enzyme are characteriz

87 Deletion of cystathionine beta-synthase (Cbs) gene, a metabolic gene

88 n in mice heterozygous for a deletion in the cystathionine beta-synthase (CBS) gene, by studying isol

89 serine hydroxymethyltransferase (SHMT), and cystathionine beta-synthase (CBS) genes and their associ

90 onine synthase (MS), MS reductase (MSR), and cystathionine beta-synthase (CBS) in the NCI60 panel of

91 Cystathionine beta-synthase (CBS) is a heme-dependent an

92 Cystathionine beta-synthase (CBS) is a key enzyme in hum

93 Cystathionine beta-synthase (CBS) is a key enzyme in sul

94 Cystathionine beta-synthase (CBS) is a key enzyme of the

95 Cystathionine beta-synthase (CBS) is a pyridoxal phospha

96 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-depe

97 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phos

98 Cystathionine beta-synthase (CBS) is a pyridoxal-phospha

99 Cystathionine beta-synthase (CBS) is a tetrameric heme p

100 Human cystathionine beta-synthase (CBS) is a unique pyridoxal

101 Human cystathionine beta-synthase (CBS) is a unique pyridoxal-

102 Cystathionine beta-synthase (CBS) is an enzyme that cond

103 Human cystathionine beta-synthase (CBS) is an essential enzyme

104 Cystathionine beta-synthase (CBS) is an essential metabo

105 Cystathionine beta-synthase (CBS) is an essential pyrido

106 The gene for cystathionine beta-synthase (CBS) is located on chromoso

107 Cystathionine beta-synthase (CBS) is the first and rate-

108 omocysteinemia due to genetic alterations in cystathionine beta-synthase (Cbs) or methylenetetrahydro

109 dition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydro

110 Cystathionine beta-synthase (CBS) plays a central role i

111 nism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/

112 mice deficient in the H(2)S-producing enzyme cystathionine beta-synthase (CBS) survive longer with re

113 Wild-type and cystathionine beta-synthase (CBS)(+/-) HHcy mice were tr

114 Cystathionine beta-synthase (CBS), a key enzyme in the m

115 Human cystathionine beta-synthase (CBS), a novel heme-containi

116 Cystathionine beta-synthase (CBS), a pyridoxal 5'-phosph

117 ine clearance converge at the active site of cystathionine beta-synthase (CBS), a pyridoxal phosphate

118 fide (H(2)S) donor GYY4137 or overexpressing cystathionine beta-synthase (CBS), an enzyme involved in

119 Patients with homocystinuria lack the enzyme cystathionine beta-synthase (CBS), and many of these ind

120 Cystathionine beta-synthase (CBS), condensing homocystei

121 gen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma l

122 the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed i

123 d metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accum

124 of the genes for apolipoprotein E (apoE) and cystathionine beta-synthase (CBS), which converts Hcy to

125 mitting step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to c

126 Cystathionine beta-synthase (CBS)-deficient patients are

127 On a hyperhomocysteinemic diet, cystathionine beta-synthase (Cbs)-heterozygous mice deve

128 ionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).

129 ted by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).

130 omocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).

131 >C), methionine synthase (MS 2756A-->G), and cystathionine-beta-synthase (CBS 844ins68) on risk for d

132 C57BL/6J (wild-type) and cystathionine-beta-synthase (CBS(+/-)) mice, treated wit

133 emic mice deficient in the Cbs gene encoding cystathionine-beta-synthase (Cbs(+/-)) to evaluate retin

134 The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrog

135 ort in DS cells is due to high expression of cystathionine-beta-synthase (CBS) and subsequent overpro

136 levels of two chromosome 21-localized genes, cystathionine-beta-synthase (CBS) and superoxide dismuta

137 Cystathionine-beta-synthase (CBS) deficiency is a human

138 Individuals with homozygous deficiency in cystathionine-beta-synthase (CBS) develop high levels of

139 e, we determined the role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 s

140 requires ATP, which binds to the C-terminal cystathionine-beta-synthase (CBS) domain of SpoIVFB.

141 PR) includes a unique structure known as the cystathionine-beta-synthase (CBS) domain, though the rol

142 Tandem cystathionine-beta-synthase (CBS) domains in the ATP-bin

143 to the transmembrane part or to cytoplasmic cystathionine-beta-synthase (CBS) domains of ClC-7.

144 The cystathionine-beta-synthase (CBS) gene (localized to chr

145 ertion in the coding region of exon 8 of the cystathionine-beta-synthase (CBS) gene in a single patie

146 ficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal di

147 ve up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resul

148 e-homocysteine methyltransferase (Bhmt), and cystathionine-beta-synthase (Cbs) were up-regulated, but

149 Mice deficient in cystathionine-beta-synthase (cbs) were used as a model o

150 of both cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), 2 major enzymes for e

151 levels of the chromosome 21-localized gene, cystathionine-beta-synthase (CBS), in DS myeloblasts.

152 thionine adenosyltransferase 1alpha (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofo

153 Cystathionine-beta-synthase (CBS)-pair domain divalent m

154 heterozygous for disruption of the gene for cystathionine-beta-synthase (Cbs+/-) and C57BL/6 (Cbs+/+

155 Cystathionine beta-synthase [CBS; l-serine hydro-lyase (

156 1298A>C, methionine synthase [MTR] 2756A>G, cystathionine beta-synthase [CBS] 844ins68, and methioni

157 ntracellular carboxy-terminus containing two cystathionine-beta-synthase (CBS1 and CBS2) domains.

158 The C-terminal region of human cystathionine beta-synthase contains two hydrophobic mot

159 ound a single nucleotide polymorphism within cystathionine beta-synthase (CYS4) that causes multi-dru

160 we demonstrate that inactivation of putative cystathionine beta-synthase, cystathionine gamma-lyase,

161 These include cystathionine beta-synthase, cystathionine-gamma-lyase,

162 Here we show that Drosophila cystathionine beta-synthase (dCBS), which catalyzes the

163 sensitivity to chemotherapeutic agents (eg, cystathionine beta synthase, dCMP deaminase, and CTP syn

164 erhomocysteinemia may be due to heterozygous cystathionine beta-synthase defect or B6 deficiency.

165 oprotection, its chronic increase such as in cystathionine beta-synthase deficiency may pose a proble

166 Homocystinuria due to cystathionine beta-synthase deficiency was confirmed by

167 WT and Cystathionine beta-Synthase deficient (CBS+/-) mice repr

168 Heterozygous cystathionine beta-synthase-deficient (CBS((-/+))) mice

169 Heterozygous cystathionine beta-synthase-deficient (CBS(+/-)) and wil

170 dilated cerebral arterioles in heterozygous cystathionine beta-synthase-deficient (CBS(+/-)) mice an

171 Classical cystathionine beta-synthase-deficient homocystinuria (HC

172 Cystathionine beta-synthase-deficient homocystinuria (HC

173 Cystathionine beta-synthase-deficient homocystinuria (HC

174 The lean phenotype of cystathionine beta-synthase-deficient homocystinuria and

175 g-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.

176 einylation impairs collagen cross-linking in cystathionine beta-synthase-deficient mice: a novel mech

177 In hyperhomocysteinemic human cells and cystathionine beta-synthase-deficient mouse brains, we f

178 PON1 affects plasma N-Hcy-protein levels in cystathionine beta-synthase-deficient patients (n=28).

179 n (SIS), biofilm-related region 2 (B2) and a cystathionine beta-synthase domain pair (CBS).

180 e and stability of PAE2072, a dimeric tandem cystathionine beta-synthase domain protein from the hype

181 ontain a sugar isomerase domain and a tandem cystathionine beta-synthase domain.

182 Interestingly, both enzymes contain a cystathionine-beta-synthase domain (CBS).

183 rt or deletion of the last 11 amino acids of cystathionine-beta-synthase domain 1 gives rise to funct

184 zed domain of unknown function (DUF21) and a cystathionine-beta-synthase domain.

185 Among these are CP12-CBS (for cystathionine-beta-synthase) domain fusions.

186 Cystathionine beta-synthase domains are found in a myria

187 -phosphate isomerases but lacking the tandem cystathionine beta-synthase domains found in the other a

188 eep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamid

189 entified KINgamma, a protein containing four cystathionine beta-synthase domains, as an interacting p

190 rase domain of E. coli KdsD, lacking the two cystathionine beta-synthase domains, demonstrated API ac

191 e potential ATP binding by the intracellular cystathionine beta-synthase domains.

192 d large cytoplasmic C-termini containing two cystathionine-beta-synthase domains (CBS1 and CBS2) that

193 300 million years ago in a proto-reptile by cystathionine beta-synthase duplication, cysteine lyase

194 Reactions catalyzed by the cystathionine beta-synthase enzyme (CBS) are one possibl

195 We identify the cystathionine beta-synthase enzyme (CBS) as a highly rec

196 No changes were observed in cystathionine beta-synthase expression, immunolocalized

197 properties of a truncated catalytic core of cystathionine beta-synthase extending from residues 1 th

198 Cystathionine beta-synthase found in yeast catalyzes a p

199 Our studies of the reaction mechanism of cystathionine beta-synthase from Saccharomyces cerevisia

200 Our studies of cystathionine beta-synthase from Saccharomyces cerevisia

201 Our studies of the reaction mechanism of cystathionine beta-synthase from yeast (Saccharomyces ce

202 Cystathionine beta-synthase from yeast (Saccharomyces ce

203 eterozygous for a targeted disruption of the cystathionine beta-synthase gene (Cbs+/-) and wild-type

204 tabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate

205 The human cystathionine beta-synthase gene promoters -1a and -1b a

206 te reductase gene or with 3 mutations of the cystathionine beta-synthase gene.

207 s in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively.

208 h purified mammalian methionine synthase and cystathionine beta-synthase have revealed the oxidative

209 Two classes of cystathionine beta-synthases have been identified in euk

210 ontinuous spectrophotometric assay for human cystathionine beta-synthase (hCBS).

211 Five-month-old cystathionine beta synthase heterozygous and wild-type C

212 approximately 150 muM), which was induced in cystathionine-beta synthase heterozygous mice fed a high

213 B(6)-responsive phenotype associated with a cystathionine beta-synthase-impaired homocystinuric geno

214 ed with a 4-fold lower steady-state level of cystathionine beta-synthase in a fibroblast cell line th

215 Fibroblasts from cystathionine beta-synthase -/- individuals also showed

216 treatment of diabetic rats with RA prevented cystathionine beta-synthase induction.

217 y absorption data reveal that iron in ferric cystathionine beta-synthase is 6-coordinate, with 1 high

218 Human cystathionine beta-synthase is a heme protein that catal

219 Human cystathionine beta-synthase is a hemeprotein that cataly

220 Cystathionine beta-synthase is a tetrameric hemeprotein

221 Cystathionine beta-synthase is a unique heme protein tha

222 Cystathionine beta-synthase is an unusual enzyme that re

223 The heme Soret peak of ferric cystathionine beta-synthase is at 428 nm and shifts to a

224 Cystathionine beta-synthase is modular and subjected to

225 Human cystathionine beta-synthase is one of two key enzymes in

226 PLP bound to cystathionine beta-synthase is weakly fluorescent and ex

227 A mouse model of HHcy, in which cystathionine-beta-synthase is deficient (cbs (-/-)), wa

228 vels of UNG mRNA were increased in brains of cystathionine beta-synthase knockout mice, a model for h

229 like the homologous mammalian enzymes, yeast cystathionine beta-synthase lacks a second cofactor, hem

230 ransferase and transsulfuration catalyzed by cystathionine beta-synthase leading to cystathionine.

231 ression of the gene, designated M truncatula Cystathionine-beta-Synthase-like1 (MtCBS1), using a prom

232 genetic defects resulting in deficiencies in cystathionine beta synthase, methylenetetrahydrofolate r

233 and GADD153 in ethanol-treated heterozygous cystathionine beta synthase mice.

234 yperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-m

235 Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isoth

236 it was reversed by the inhibition of either cystathionine beta-synthase or cystathionine gamma-lyase

237 s proposed in which mutagenesis is driven by cystathionine-beta-synthase overexpression and altered f

238 that ox-LDL treatment down-regulated the H2S/cystathionine-beta-synthase pathway, with increased MCP-

239 affinity probes led to the identification of cystathionine beta-synthase, peroxiredoxins, ADP/ATP car

240 PC in hyperhomocysteinemic mice deficient in cystathionine beta-synthase (plasma tHcy, 93 +/- 16 micr

241 Cystathionine beta-synthase plays a key role in the intr

242 Here we express a mutant form of the human cystathionine beta-synthase protein, I278T, in Saccharom

243 Cystathionine beta-synthase regulates endothelial functi

244 ism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxide dismutase) as po

245 ilarly, a particular M.grisea CBS1 (encoding cystathionine beta-synthase) TAGKO cDNA failed to comple

246 xample of mutations in the catalytic core of cystathionine beta-synthase that result in failure of Ad

247 inically relevant AML cell line models, high cystathionine-beta-synthase transcripts in DS CMK cells

248 the abundance of the transsulfuration enzyme cystathionine beta-synthase; treatment of diabetic rats

249 ly determine mRNA abundance for thousands of cystathionine beta-synthase variants using two experimen

250 irst evidence for redox-linked regulation of cystathionine beta-synthase which is heme-dependent.

251 OR1 induction resulted in down-regulation of Cystathionine beta-synthase, which is known to lead to i

252 oderate (88 micromol/L) HHcy were induced in cystathionine beta-synthase wild-type (Cbs(+/+)) and het

253 Treatment of cystathionine beta-synthase with hydroxylamine releases

254 We compare our results with cystathionine beta-synthase with those of related invest