ライフサイエンスコーパス: cysteine protease inhibitor

1 nhibition was abrogated by E-64, a selective cysteine protease inhibitor.

2 nd that of its complex with a small-molecule cysteine protease inhibitor.

3 inhibited by the anti-prion compound E64, a cysteine protease inhibitor.

4 increasing concentrations of a vinyl sulfone cysteine protease inhibitor.

5 oxyoxirane-2-carbonyl)-L-leucyl]-agmatine, a cysteine protease inhibitor.

6 one-based triazoles as potential nonpeptidic cysteine protease inhibitors.

7 Excystation is blocked by specific cysteine protease inhibitors.

8 es and in infected erythrocytes treated with cysteine protease inhibitors.

9 lfones as a new class of covalent reversible cysteine protease inhibitors.

10 ytes and belonging to the cystatin family of cysteine protease inhibitors.

11 en MARCH1-expressing cells were treated with cysteine protease inhibitors.

12 as metal ion-dependent, and not inhibited by cysteine protease inhibitors.

13 e degradation of TfR is partially blocked by cysteine protease inhibitors.

14 diminished specifically by lysosomal acidic cysteine protease inhibitors.

15 ut significant differences in sensitivity to cysteine protease inhibitors.

16 block in hemoglobin hydrolysis, as caused by cysteine protease inhibitors.

17 ly 2-fold) decreases in sensitivity to other cysteine protease inhibitors.

18 tivity was blocked by a subset of serine and cysteine protease inhibitors.

19 belongs to the peptidyl-diazomethane family (cysteine protease inhibitor 1, termed CP-1).

20 The lysosomal cysteine protease inhibitor 9-fluorenylmethyloxycarbonyl

21 While one of the cysteine protease inhibitors also exhibited in vitro ant

22 Serine and cysteine protease inhibitors also reduced Alternaria-ind

23 Cysteine protease inhibitors and a selective inhibitor f

24 e critical interval: Ctla2b, which encodes a cysteine protease inhibitor, and mouse homologs of KIAA0

25 show that calpain inhibition through E64, a cysteine protease inhibitor, and the highly specific cal

26 Cysteine protease inhibitors are being studied as possib

27 ncoding human cystatin B, a widely expressed cysteine protease inhibitor, are responsible for a sever

28 1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upre

29 Cysteine protease inhibitors arrest infection by the pro

30 d channels was also prevented by the caspase/cysteine protease inhibitor benzyloxycarbonyl-VAD-fluoro

31 induced apoptosis are blocked by the peptide cysteine protease inhibitor benzyloxycarbonyl-Val-Ala-As

32 nium (TEA), high extracellular potassium, or cysteine protease inhibitors block apoptosis induced by

33 Cysteine protease inhibitors block hemoglobin degradatio

34 In wild-type and knockout parasites, cysteine protease inhibitors blocked hemoglobin hydrolys

35 Cysteine protease inhibitors, but not aspartic or serine

36 The cysteine protease inhibitors CA074Me and E64d were selec

37 nd role in cellular signaling regulating the cysteine protease inhibitor calpastatin.

38 gainst SARS-CoV, and that potent noncovalent cysteine protease inhibitors can be developed with speci

39 This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic

40 esults in this report show that targeting of cysteine protease inhibitors can selectively control tum

41 lial antigens lysyl oxidase (Lox) and serine/cysteine protease inhibitor, clade E, member 1 (Serpine1

42 eatment of mice with E-64, a highly specific cysteine protease inhibitor, completely inhibits sporozo

43 control tumor cell growth and that targeted cysteine protease inhibitors could prove valuable in the

44 procal decrease in the expression of several cysteine protease inhibitors (CPI), stefin A and cystati

45 The cysteine protease inhibitor cystatin C is internalized b

46 The cysteine protease inhibitor cystatin C is thought to be

47 In contrast, the cysteine protease inhibitor cystatin C was expressed onl

48 er cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of t

49 y-state mRNA and protein levels of two major cysteine protease inhibitors, cystatin B and C, were unc

50 SpeB- phase-shift forms in the presence of a cysteine protease inhibitor demonstrated differences in

51 nd mutant cDNAs into SCp2 cells and use of a cysteine protease inhibitor demonstrated that CDP is pro

52 whole cells, whereas in isolated nuclei, the cysteine protease inhibitors did not prevent the cleavag

53 Finally, we demonstrate that irreversible cysteine protease inhibitors do not abolish the Cif cyto

54 gan culture of transgenic lenses with E64, a cysteine protease inhibitor, dramatically delayed catara

55 s efficiently inhibited by both the covalent cysteine protease inhibitor E-64 and the reversible sele

56 DeltasigB mutant through the addition of the cysteine protease inhibitor E-64 or by using Staphostati

57 easome inhibitor, but not in response to the cysteine protease inhibitor E-64 or the calpain inhibito

58 ctures of the natural product, epoxide-based cysteine protease inhibitor E-64, and its biosynthetic a

59 proteases, since they were inhibited by the cysteine protease inhibitor E-64c but not by pepstatin A

60 tes were about 3 times more sensitive to the cysteine protease inhibitors E-64 and leupeptin, and ove

61 d) cathepsin B activity was inhibited by the cysteine protease inhibitors E-64, leupeptin, Mu-Np2-Hph

62 le abnormalities similar to that seen with a cysteine protease inhibitor, E-64 (I-1).

63 hibitor, dichloroisocoumarin, but not with a cysteine protease inhibitor, E-64, abrogated completely

64 The general cysteine protease inhibitor, E-64, blocked cataract form

65 ially blocked by treating the extract with a cysteine protease inhibitor, E-64, or by infecting BEAS-

66 Previous studies using the cysteine protease inhibitor E64 and a mutant cell line t

67 Importantly, the cysteine protease inhibitor E64 prevented mucous degrada

68 acidification inhibitor ammonium chloride or cysteine protease inhibitor E64.

69 Here we show that the cysteine protease inhibitor E64d prevent activation-indu

70 activity, PLP2 activity is not sensitive to cysteine protease inhibitor E64d.

71 d tolerance of antiherbivory defenses (i.e., cysteine protease inhibitors) expressed in soybean folia

72 ile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at no

73 ecific member of the cystatin superfamily of cysteine protease inhibitors, forms amyloid in vitro sug

74 Collectively, these results indicate that a cysteine protease inhibitor from bacterial origin could

75 ides evidence that cystatin B, a non-caspase cysteine protease inhibitor, has a role in preventing ce

76 rovides a general strategy for the design of cysteine protease inhibitors having high specificity to

77 out the efficacy, selectivity, and safety of cysteine protease inhibitors in cell culture or in vivo.

78 Bax protease activity is blocked in vitro by cysteine protease inhibitors including E-64 which distin

79 Both processes are blocked by a cysteine protease inhibitor, indicating the involvement

80 t the helminth immunomodulator AvCystatin, a cysteine protease inhibitor, induces a novel regulatory

81 vivo, and this cleavage was inhibited by the cysteine protease inhibitors iodoacetamide and N-ethylma

82 scular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely reduced in both

83 knock-out clone sensitivity to aspartic and cysteine protease inhibitors is changed minimally.

84 The cystatin superfamily of cysteine protease inhibitors is composed of distinct fam

85 c T-lymphocyte antigen-2beta (CTLA-2beta), a cysteine protease inhibitor, is expressed during PR-indu

86 ic), a member of the cystatin superfamily of cysteine protease inhibitors, is expressed in the epidid

87 We now report that specific cysteine protease inhibitors kill Leishmania parasites i

88 hizonts were cultured in the presence of the cysteine protease inhibitor, l-transepoxy-succinyl-leucy

89 the cystatin B (CysB) gene, an intracellular cysteine protease inhibitor, lead to this human disease.

90 bond-forming enzymes generated a library of cysteine protease inhibitors, leading to more potent cat

91 esis was tested directly by showing that the cysteine protease inhibitor leupeptin prevented Sp1 degr

92 Coinfusion of Abeta40 with the cysteine protease inhibitor leupeptin resulted in increa

93 he TAP-independent pathway is blocked by the cysteine protease inhibitor, leupeptin, but not by prote

94 Administration of the cysteine protease inhibitor, leupeptin, promoted accumul

95 2 x 10(-)(3) M [Ca(2+)](o) and 0.5 mM of the cysteine protease inhibitor, leupeptin, T:(g) increased

96 Kfyve kinase inhibitor apilimod(2-4) and the cysteine protease inhibitors MDL-28170, Z LVG CHN2, VBY-

97 Treatment of recombinant AC with the cysteine protease inhibitor, methyl methanethiosulfonate

98 The effect of one of the vinyl sulfone cysteine protease inhibitors, Mu-Leu-HomoPhe-vinylsulfon

99 The cysteine protease inhibitor N-acetyl-leu-leu-norleucinal

100 The cysteine protease inhibitor N-acetyl-leucinyl-leucinyl-n

101 trin from the membrane and is blocked by the cysteine protease inhibitor N-acetyl-leucyl-leucyl-norle

102 ipain-active extracellular extracts with the cysteine protease inhibitor Nalpha-p-tosyl-l-lysine chlo

103 creased with the addition of ZnCl(2) and the cysteine protease inhibitor NEM.

104 lasmepsin processing is not blocked by other cysteine protease inhibitors, nor by the proteasome inhi

105 h stage larvae (L4) by testing the effect of cysteine protease inhibitors on the survival of third st

106 In this study, the roles of rice bran cysteine protease inhibitors, oryzacystatins, were consi

107 se inhibitor 3,4-dichloroisocoumarin and the cysteine protease inhibitor p-(chloromercuri) benzenesul

108 that was blocked by the baculoviral-derived cysteine protease inhibitor P35.

109 Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the

110 Furthermore, preincubation with a cysteine protease inhibitor prevented nuclear entry of g

111 ) ethyl chloromethyl ketone (TPCK), a serine-cysteine protease inhibitor, prevents the release of vir

112 E-64 is an irreversible cysteine protease inhibitor prominently used in chemical

113 In vitro, cysteine protease inhibitors restored granularity, demon

114 lecule inhibitor library consisting of known cysteine protease inhibitor scaffolds.

115 The serine/cysteine protease inhibitor SCCA1 (SERPINB3) is upregula

116 is insensitive to inhibition by the soybean cysteine protease inhibitor (scN).

117 The three cysteine protease inhibitors significantly improved beha

118 structural analysis between the hCLD and the cysteine protease inhibitor stefin A showed why the hCLD

119 curs within lysosomes, as it is prevented by cysteine protease inhibitors such as E64, but not by the

120 JNK activation if apoptosis was blocked by a cysteine protease inhibitor, suggesting that under these

121 In contrast, a cysteine protease inhibitor that also blocks apoptosis h

122 ter, is the prototype of this novel class of cysteine protease inhibitor that emerged from the search

123 CST6 is a secreted type 2 cystatin, a cysteine protease inhibitor that regulates lysosomal cys

124 onstrate the value of a second generation of cysteine protease inhibitors that comprise a single agen

125 ystatin SN (CST1) and cystatin SA (CST2) are cysteine protease inhibitors that protect against allerg

126 drazides represent a new class of unreactive cysteine protease inhibitors that share a common mechani

127 plex with a class of potent, small molecule, cysteine protease inhibitors, the vinyl sulfones.

128 extracellular protein preparations with the cysteine protease inhibitor TLCK.

129 lution as well as complexes with the general cysteine protease inhibitor trans-epoxysuccinyl-l-leucyl

130 virions was inhibited by the broad spectrum cysteine protease inhibitor trans-epoxysuccinyl-l-leucyl

131 In cysteine protease inhibitor-treated, infected erythrocyt

132 Weak caseinolytic activity inhibitable by cysteine protease inhibitors was copurified with Cpl imm

133 l-characterized apoplastic effector EPIC1, a cysteine protease inhibitor, was also secreted from haus

134 shares homology with the cystatin family of cysteine protease inhibitors, we first analyzed the effe

135 In summary, parasites resistant to a cysteine protease inhibitor were selected, although the

136 Targeted libraries of ketone-based cysteine protease inhibitors were synthesized and screen

137 nd post-ischemic cytoprotective effects of a cysteine protease inhibitor which does not block calpain

138 Cysteine protease inhibitors which are relatively select

139 N-Acetyl-leucyl-leucyl-norleucinal, a cysteine protease inhibitor, which directly protects apo

140 including periostin, cadherin-26, and type 2 cysteine protease inhibitors), while C1 was enriched in

141 ystatins are a family of naturally occurring cysteine protease inhibitors, yet the target proteases a

142 up-regulation was completely blocked by the cysteine protease inhibitor Z-VAD-fmk (benzyloxycarbonyl

143 The enzyme was sensitive to cysteine protease inhibitors, Zn(2+), and Ni(2+).

144 -induced cleavage of Mst1 was blocked by the cysteine protease inhibitor ZVAD-fmk, the more selective