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1 ritically dependent on palmitoylation of its cysteine-rich (173)CCPCC(177) motif and are also highly
6 een ORF31 and ORF24, (ii) the amino-terminal cysteine-rich and carboxyl-terminal basic domains of ORF
7 pe lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at the cent
8 double-ring "head," in which the N-terminal cysteine-rich and fibronectin II domains were folded bac
11 analyses that, in binding VWF, the ADAMTS13 cysteine-rich and spacer domain exosites bring enzyme an
12 mutagenesis of ADAMTS-4 identified that the cysteine-rich and spacer domains are responsible for bin
13 structs showed that membrane-proximal stalk, cysteine-rich, and disintegrin domains of ADAM10 mediate
15 terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind substrates and
17 RNA-Seq analysis showed that both ID2 and Cysteine-rich angiogenic inducer 61 (CYR61) expression l
18 s to up-regulate the target genes, including cysteine-rich angiogenic inducer 61 (CYR61), connective
22 xins delta-SVIE and MrVIA), nodule-specific, cysteine-rich antimicrobial peptides (NCR), and a malari
25 zinc probe monitoring, for identification of cysteine-rich binding sites with nanomolar and picomolar
28 and both auxiliary clusters are housed in a cysteine-rich C-terminal domain, termed SPASM domain, th
33 receptors (FRalpha, FRbeta and FRgamma) are cysteine-rich cell-surface glycoproteins that bind folat
34 In Arabidopsis, pollen tubes are guided by cysteine-rich chemoattractants to target the female game
37 allothionein genes (CMT1 and CMT2), encoding cysteine-rich Cu binding and detoxifying proteins, whose
38 ehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich) domain using engineered glycans
40 cognized a protein complex consisting of the cysteine-rich (CysR), fibronectin-like type II (FnII), a
41 Def1 and MtDef4 from Medicago spp. are small cysteine-rich defensins with potent antifungal activity
42 2.3 A crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show th
43 y, homozygous deletion of src homology 3 and cysteine rich domain 3 (Stac3) in mice results in comple
46 todomain where loss of an aromatic moiety in cysteine-rich domain (CRD) 2 results in TRAPS disease-as
49 y LGR5 and RNF43, with its rod module of the cysteine-rich domain (CRD) contacting LGR5 and a hairpin
50 n binding interface to the RAS G domain, its cysteine-rich domain (CRD) is responsible for associatio
52 ular protease-associated (PA) domain and the cysteine-rich domain (CRD) of frizzled and the intracell
53 Wnt cis-unsaturated fatty acyl groups by the cysteine-rich domain (CRD) of FZD receptors remains elus
55 we observed binding of carbamazepine to the cysteine-rich domain (CRD) of the Wnt receptor FZD8 usin
56 Wnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain
58 the conserved Wnt-binding site known as the cysteine-rich domain (CRD), with the highest affinity to
66 ering analyses of Norrin in complex with Fz4 cysteine-rich domain (Fz4CRD), of this complex bound wit
68 UL144 utilizes residues from its N-terminal cysteine-rich domain 1 (CRD1) to interact uniquely with
70 and fish null for the protein Stac3 (SH3 and cysteine-rich domain 3) but did not establish the functi
73 ibition by sequestering the membrane-binding cysteine-rich domain and blocking dimerization of the BR
74 ges formed at C349/C356 and C465/C468 of the cysteine-rich domain are necessary for the enhancement o
75 Akt prevents binding of Rubicon (RUN domain cysteine-rich domain containing beclin1-interacting prot
76 a catalytically inactive PARP6 mutant, or a cysteine-rich domain deletion mutant that has significan
78 ring mutation in the evolutionally conserved cysteine-rich domain had more severe defects in ER exit
79 es localized to the N-terminal extracellular cysteine-rich domain has been described, a functional ro
81 ary, we present extensive mapping of WNT-FZD cysteine-rich domain interactions complemented by analys
86 d on structural studies of the TWEAK-binding cysteine-rich domain of Fn14, several homology models of
87 Wnt's fatty acyl moiety by the extracellular cysteine-rich domain of FZD has become clear only very r
88 s are mediated by an HS-binding motif in the cysteine-rich domain of HHIP1 that is required for its l
93 for ROR1/ROR2 heterooligomerization and the cysteine-rich domain or intracellular proline-rich domai
94 cipated architecture in which the C-terminal cysteine-rich domain partially occludes the enzyme activ
95 axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute
97 structure of this newly characterized small cysteine-rich domain suggests potential involvement of J
98 ansferase domain, ankyrin repeat domain, and cysteine-rich domain) were unnecessary for G9a coactivat
99 removal of a membrane-tethering domain, the cysteine-rich domain, and a disintegrin domain, respecti
100 is coupled to the transmembrane domain via a cysteine-rich domain, and LBD closure seems to be the fi
104 e closed-open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane doma
107 t interaction of the two receptors via their cysteine-rich domains also promotes Ror2-mediated papc e
108 2 encodes four N-terminal scavenger receptor cysteine-rich domains and the highly conserved C-termina
112 present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong com
113 e in cultured retinal axons, suggesting that cysteine-rich domains interact with and activate an inhi
115 ng purified WNTs, we show that different FZD cysteine-rich domains prefer to bind to distinct WNTs wi
116 g Venus flytrap domains, which are linked by cysteine-rich domains to their 7-transmembrane domains.
125 growth, thereby linking the redox status of cysteine-rich envelope proteins with progression of the
128 modified through the removal or addition of cysteine-rich extracellular domains to produce a panel o
129 Gp340 is a member of the scavenger receptor cysteine-rich family of innate immune molecules and also
130 L1 belongs to the group B scavenger receptor cysteine-rich family of proteins, where the CD163-L1 gen
134 sitively charged residues at the base of the cysteine-rich head and two variant residues in the dorsa
135 fluorometry to investigate movements in the cysteine-rich head domain of the rat P2X1R (A118-I125) t
137 lobes coordinated by positive charge on the cysteine-rich head region and residues in the adjacent d
138 oximately 135-fold in chimeras replacing the cysteine-rich head, and the dorsal fin region below it i
139 etric beta-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5
140 bodies requires an evolutionarily conserved cysteine-rich hydrophobic motif harbored within a unique
142 eractions are mediated by different types of cysteine-rich interdomain region (CIDR) domains found in
144 cassette bound to brain endothelium and the cysteine-rich interdomain region 1 inhibited binding of
145 Plasmodium falciparum virulence factors: two cysteine-rich interdomain regions (CIDR) alpha1 (IT4var1
146 ge extracellular ectodomains made from CIDR (cysteine-rich interdomain regions) and DBL (Duffy-bindin
147 ual cysteine residues within the non-amyloid cysteine-rich Kringle-like domain stabilizes the disulfi
150 a large nuclear protein that shares a novel cysteine rich motif with known transcription factors.
151 critically depends on palmitoylation of its cysteine-rich motif (-CCPCC-) and is modulated by the me
153 ch is dependent upon a set of four conserved cysteine-rich motifs in the C-terminal domain of ORF66.
154 inal domain, which contains highly conserved cysteine-rich motifs reminiscent of zinc finger motifs.
156 mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmemb
157 domains that are protease-resistant and has cysteine-rich N and C termini responsible for polymeriza
159 vent that is induced by host nodule-specific cysteine rich (NCR) antimicrobial peptides and requires
161 onstrate that NFS2 encodes a nodule-specific cysteine-rich (NCR) peptide that acts to promote bacteri
163 able of degrading a range of nodule-specific cysteine-rich (NCR) peptides encoded by M. truncatula.
164 pproximately 600 of them are nodule-specific cysteine-rich (NCR) peptides produced in the rhizobium-i
165 rentiation is driven by host nodule-specific cysteine-rich (NCR) peptides that orchestrate the adapta
166 me Medicago truncatula, ~700 nodule-specific cysteine-rich (NCR) peptides with conserved cysteine sig
167 ber of antimicrobial peptides, called nodule cysteine-rich (NCR) peptides, to control the outcome of
168 der control by an arsenal of nodule-specific cysteine-rich (NCR) peptides, which induce the bacteria
171 expression of the secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes
174 male S-determinant, PrpS PrsS belongs to the cysteine-rich peptide family, whose members activate div
175 fied roseltide rT1, a hyperstable 27-residue cysteine-rich peptide from Hibiscus sabdariffa, as a kno
177 Inhibition of the enzyme by this 66-mer cysteine-rich peptide is mediated by its C-terminal sequ
178 clinical relevance of this hepatic ~2.8 kDa cysteine-rich peptide is rapidly increasing, since alter
182 eptor kinase family and their ligands, 5-kDa cysteine-rich peptide rapid alkalinization factors (RALF
184 is a first-in-class mitochondria-targeting, cysteine-rich peptide with potentials to be developed in
186 s process is orchestrated by nodule-specific cysteine-rich peptides (NCRs) delivered into developing
188 ibes chemistry that is broadly applicable to cysteine-rich peptides and the influence of a fourth dis
190 es a new element of structural diversity for cysteine-rich peptides as well as increased protease res
191 by extrapolation, our findings suggest that cysteine-rich peptides diversified for a variety of spec
192 rminus for the capture reaction, which makes cysteine-rich peptides ideal candidates for the entropy-
193 as likely due to the coordination of Zn with cysteine-rich peptides in the root endodermis, suggestin
195 Defensins are short cationic, amphiphilic, cysteine-rich peptides that constitute the front-line im
198 most abundant transcripts encode families of cysteine-rich peptides, implying roles in cell-cell reco
201 Cystine knot alpha-amylase inhibitors are cysteine-rich, proline-rich peptides found in the Amaran
203 ied a conserved GPI-linked parasite protein, Cysteine-rich protective antigen (CyRPA) as an interacti
204 log 5 (RH5), RH5 interacting protein (RIPR), cysteine-rich protective antigen (CyRPA), apical membran
210 bronectin 1 (FN1), interleukin-1beta (IL1B), cysteine-rich protein 61 (CYR61), and jagged-1 (JAG1), t
212 n , NOTCH1, and nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor
213 ns in the gene coding for reversion-inducing cysteine-rich protein containing Kazal motifs (Reck).
214 efficient modification of acceptor sites in cysteine-rich protein domains before disulfide bond form
218 wth factor-like (EGF) repeats are also small cysteine-rich protein motifs that can be O-glycosylated
220 ilitates the import and oxidative folding of cysteine-rich protein substrates into the mitochondrial
223 the tumor suppressor gene reversion-inducing cysteine-rich protein with kazal motifs (RECK) by two ke
224 nd Western blot analysis, reversion-inducing cysteine-rich protein with kazal motifs (Reck) was ident
225 an inactivating lesion in reversion-inducing cysteine-rich protein with Kazal motifs [reck; also know
226 the Notch activator RECK (reversion-inducing cysteine-rich protein with kazal motifs) by releasing it
227 he membrane protein RECK (Reversion-inducing cysteine-rich protein with kazal motifs) controls breast
228 molecule alpha (RELMalpha), a small secreted cysteine-rich protein, is expressed by epidermal keratin
229 press such a large, highly glycosylated, and cysteine-rich protein, limiting structural studies to LR
230 Metallothioneins are a family of small, cysteine rich proteins that have been implicated in a ra
232 llothioneins (MTs) are low-molecular-weight, cysteine-rich proteins believed to play a role in cytoso
234 ners with the oxidoreductase Mia40 to import cysteine-rich proteins in the mitochondrial intermembran
235 ing of Mia40 and Erv1 mediates the import of cysteine-rich proteins into the mitochondrial intermembr
236 s the hair and nails by binding and altering cysteine-rich proteins of hair and nails or by means of
238 bz linker can be applied to the synthesis of cysteine-rich proteins such the cyclotides Kalata B1 and
239 etallothioneins (MTs) constitute a family of cysteine-rich proteins that play key biological roles fo
241 ordin-like (KCP) protein, one of a family of cysteine-rich proteins, suppresses TGF-beta signaling by
244 alysis revealed the activation of members of cysteine-rich receptor-like kinase (CRK) genes in the ba
246 ions in either the core region (K41A) or the cysteine-rich region (C30G) of Tat abrogated its ability
248 roximity to the glutamate binding domain and cysteine-rich region (R375G and G396V) show both decreas
251 Conserved hydrophobic amino acids within the cysteine-rich region of Erv46 were also required for ret
254 we find that a few basic amino acids in the cysteine-rich region of SNAP25 and SNAP23 are essential
255 well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutation
256 ts suggesting that disulfide linkages in the cysteine-rich region perform a role in releasing bound c
257 bunit and define an approximately 60 residue cysteine-rich region that is unique to the Erv46 family
258 replication initiation factor, followed by a cysteine-rich region, predicted to fold as a Zn knuckle.
259 nsus as TTYRAA and determine that two tandem cysteine rich regions are required for high-affinity DNA
260 s of both the human and Xenopus laevis RecQ4 cysteine-rich regions, and showed by NMR spectroscopy th
262 ocation of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized b
263 either the N-terminal myristoylation nor the cysteine-rich RING H2 domain of rapsyn is required for i
264 wing the identification of the male (S-locus Cysteine Rich/S-locus Protein 11) and female (S Receptor
265 -locus receptor kinase (SRK) and the S-locus cysteine-rich (SCR) genes, as well as unlinked modifier
266 d the other encoding its ligand, the S-locus cysteine-rich (SCR) protein, which is localized in the p
270 wn that allurin is a truncated member of the Cysteine-Rich Secretory Protein (CRISP) family, whose me
271 ssion of a human CAP superfamily member, the cysteine-rich secretory protein 2 (CRISP2), rescues the
272 unctional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis r
273 of action, the CAP protein superfamily [i.e. cysteine-rich secretory proteins (CRISP), antigen 5, and
275 ssion of genes encoding highly glycosylated, cysteine-rich secretory proteins, thus preventing ER ove
276 R-1/Sc7 (SCP/TAPS) domain, also known as the cysteine-rich secretory proteins/antigen 5/pathogenesis-
277 protein tablysin-15 is a member of the CAP (cysteine-rich secretory, antigen 5, and pathogenesis-rel
278 monstrate that noncatalytic thrombospondin-1/cysteine-rich/spacer domains are principal modifiers of
280 the expression of secreted protein, acidic, cysteine rich (SPARC), myocilin, angiopoietin-like facto
283 the substitution of CD163 scavenger receptor cysteine-rich (SRCR) domain 5 with a homolog of human CD
284 he presence of the fourth scavenger receptor-cysteine-rich (SRCR) domain of LOXL2, which is also the
286 to result in between 7-20 scavenger-receptor cysteine-rich (SRCR) domains within each SAG molecule.
287 es involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer cons
289 isingly, Loxl3 N-terminal scavenger receptor cysteine-rich (SRCR) repeats, rather than the C-terminal
290 o-receptors belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a mu
293 o span 22 kb including exons 14-17 of CRIM1 (cysteine-rich transmembrane bone morphogenetic protein (
295 hrough molecular dynamics simulations on the cysteine-rich trypsin inhibitor MCoTI-II with three disu
297 l of exon 2 of the Sep15 gene coding for the cysteine-rich UDP-glucose:glycoprotein glucosyltransfera
299 ns, adipose differentiation-related protein, cysteine-rich with epidermal growth factor-like domains
300 opsis thaliana) that has similarities to the cysteine-rich zinc-binding domain of DnaJ chaperones.