ライフサイエンスコーパス: cytochrome

1 ration and decreased the abundance of c-type cytochromes.

2 es the covalent attachment of heme to c-type cytochromes.

3 microscopy, to understand the involvement of cytochromes and other possible electron-mediating specie

4 es, showed higher activity of peroxidase and cytochrome, and gave largest removal of OMPs (removal of

5 o investigating the quantity and function of cytochromes, as well as the emergence of Fe-containing p

6 with PSII intermediate complexes containing cytochrome b (559) Complementation of the Chlamydomonas

7 tein, we similarly modified Escherichia coli cytochrome b (562) and the resulting protein behaves in

8 and decreased electron transport through the cytochrome b (6) f complex.

9 tutively high CEF through the associated PSI-cytochrome b (6) f supercomplex to support robust growth

10 nes cytochrome c oxidase subunit I (COI) and Cytochrome b as well as in the nuclear internal transcri

11 ocol that targets the parasite mitochondrial cytochrome b gene.

12 DPH), cytochrome b(5) reductase (b(5)R), and cytochrome b(5) (cyt b(5)).

13 transport chain composed of NADH (or NADPH), cytochrome b(5) reductase (b(5)R), and cytochrome b(5) (

14 in and methemoglobin (MetHb) concentrations, cytochrome b(5) reductase (CYB5R) enzyme activities, gen

15 s oxidized and ring-opened by enzymes in the cytochrome b(561) and gluconolactonase families, respect

16 e high-resolution melting profiles from COI, cytochrome b, and 16S ribosomal RNA gene PCR products.

17 Cygb and the reducing systems, cytochrome b5 (B5)/cytochrome b5 reductase (B5R) and cyt

18 ly demethylates m6A of targeted mRNA such as cytochrome b5 form A (CYB5A) to increase its mRNA stabil

19 and the reducing systems, cytochrome b5 (B5)/cytochrome b5 reductase (B5R) and cytochrome P450 reduct

20 CIV) forms SCs of varying stoichiometry with cytochrome bc (1) (CIII).

21 ompounds may target the Q(o) binding site of cytochrome bc(1).

22 The essentiality of the cytochrome bc(1):aa(3) for optimum growth is illustrated

23 piration and bioenergetics predominantly via cytochrome bd oxidase, and that H(2)S reverses *NO-media

24 complexes (fox, sox, dox and a new putative cytochrome bd) are prevalent in many species (even facul

25 not menaquinone and demethylmenaquinone) and cytochrome bd-I (but not cytochromes bo(3) and bd-II) al

26 rmined the structure of the Escherichia coli cytochrome bd-I oxidase by single-particle cryo-electron

27 ed that in Escherichia coli the component of cytochrome bd-I terminal oxidase, the CydDC complex, shu

28 ehydrogenases and ubiquinone at the level of cytochrome bd-I, which results in oxidative stress.

29 cryptic appBCX genes, predicted to encode a cytochrome bd-II oxidase, conferred a fitness advantage

30 Cytochrome bo (3) ubiquinol oxidase is a transmembrane p

31 hylmenaquinone) and cytochrome bd-I (but not cytochromes bo(3) and bd-II) also had completely abolish

32 ed the effects of heme loss on mitochondrial cytochromes by knocking down cytochrome c/c (1) heme lya

33 state abundances of both c-type cytochromes, cytochrome c (1) and cytochrome c The observed reduction

34 ndance of complex III could be attributed to cytochrome c (1) being one of its subunits.

35 loys a Trp191(*+) radical to oxidize reduced cytochrome c (Cc).

36 that miR-34a regulates the BBB by targeting cytochrome c (CYC) in vitro.

37 Cytochrome c (Cyt c) has evolved to become an important

38 Cytochrome c (cyt c) is known for its role in the electr

39 Herein, the structural change of cytochrome c (Cyt c) upon encapsulation within a hierarc

40 the adsorption behavior of the redox protein cytochrome c (Cyt-C) onto different interfaces, namely,

41 of mitochondrial permeability and release of cytochrome c (CytC) and apoptosis-inducing factor (AIF)

42 s circumvented by deleting the gene encoding cytochrome c (M) (CytM), a cryptic c-type heme protein w

43 nificantly lower ROS, cleaved caspase-3, and cytochrome c activities, leading to reduced spinal cord

44 ilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome.

45 Furthermore, translocation of mitochondrial cytochrome C and AIF was significantly alleviated in the

46 tive neurons, translocation of mitochondrial cytochrome C and apoptosis inducing factor (AIF), LC3B-p

47 ed minority MOMP noted by minimal release of cytochrome C and limited caspase 3 activation, which res

48 Broadening our scope to cytochrome c and lysozyme, we showed that although compa

49 n applied to a simple two-protein mixture of cytochrome c and myoglobin.

50 is and the binding of amino acid residues in cytochrome c and neuroglobin.

51 Cytochrome c binds cardiolipin on the concave surface of

52 led device (CCD) detector after digesting of cytochrome c by immobilized trypsin enzymes on NAA-NH(2)

53 A deviant subgroup is the cytochrome c dependent NO reductases (cNOR), which reduc

54 rt via an Hmc complex (high-molecular-weight cytochrome c encoded by dvu0531-dvu0536) and the Fe-only

55 The hybrid CcmH increased cytochrome c expression by increasing the abundance of C

56 ns that contain multiple heme groups (diheme cytochrome c from Rhodobacter sphaeroides and Desulfovib

57 y interact with electrodes by expressing the cytochrome c from Shewanella oneidensis MR-1.

58 The determination of cytochrome c in the human serum sample is a regular medi

59 c relationship with the concentration of the cytochrome c in the range of 1-100 nM.

60 ted to the mitochondria's ability to release cytochrome c into the cytosol, which triggers the apopto

61 can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol.

62 sensing principle of proposed IRS sensor to cytochrome c is based on a change in the intensity of th

63 istae, we estimate the LPR of cardiolipin to cytochrome c is between 50 and 100.

64 We have reported that once in the cytosol, cytochrome c is targeted for degradation by the E3 ligas

65 The example of cytochrome c is used to demonstrate how StructureDistill

66 to the limited compatibility of the E. coli cytochrome c maturation (Ccm) systems with MR-1 cytochro

67 lies that OXA2a is required for the system I cytochrome c maturation of Arabidopsis.

68 umed to form the heme lyase component of the cytochrome c maturation pathway.

69 Due to the interaction of OXA2a with Cytochrome c maturation protein CcmF C-terminal-like pro

70 f a soluble heme lyase from an organism with cytochrome c maturation system III could functionally co

71 Thus, cytochrome c may have adapted to its native environment

72 Cytochrome c nitrite reductase (NrfA) catalyzes the redu

73 from G. lovleyi represents a new subclass of cytochrome c nitrite reductase.

74 Here, we identify the proposed cbb (3)-type cytochrome c oxidase (cbb (3)-Cox) assembly factor CcoG

75 o hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen de

76 gen that we consume, reducing it to water by cytochrome c oxidase (CcO).

77 ivities of succinate dehydrogenase (SDH) and cytochrome c oxidase (CCO).

78 In Saccharomyces cerevisiae, cytochrome c oxidase (CIV) forms SCs of varying stoichio

79 dendritic mitochondria and histochemistry of cytochrome c oxidase (CO) activity were examined in pre-

80 We describe human COX6B2, a component of cytochrome c oxidase (complex IV).

81 llar cristae was associated with the gain of cytochrome c oxidase (COX) function, and the COX subunit

82 ng cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, pr

83 his prediction measuring oxidation states of cytochrome c oxidase (oxCCO), an intracellular marker of

84 enase, pyruvate kinase, creatine kinase, and cytochrome c oxidase activities, and increased myoglobin

85 iron-sulfur assembly proteins)1/2 and COX10 (cytochrome c oxidase assembly protein-10), indicating en

86 he matrix side into the inner membrane while Cytochrome c oxidase assembly protein18 (Cox18/Oxa2) is

87 ression of key mitochondrial genes including cytochrome C oxidase copper chaperone (COX17) and ATP Sy

88 der characterized with neurodegeneration and cytochrome c oxidase deficiency.

89 cluding impaired energy generation caused by cytochrome c oxidase dysfunction in the mitochondria.

90 ulated with the Anr-controlled high-affinity cytochrome c oxidase genes.

91 , extracted DNA and sequenced mitochondrial (cytochrome c oxidase I [mtCOI]) and nuclear (small subun

92 tochondrial function that directly activates cytochrome c oxidase in the mitochondria and functions i

93 ted copper to the mitochondria and increased cytochrome c oxidase levels in the brain.

94 We assembled individual mitochondrial cytochrome c oxidase subunit 1 (COI) sequences (n = 866)

95 Complex III's Rieske Fe-S center and COX4i2 [cytochrome c oxidase subunit 4 isoform 2] in Complex IV)

96 in fragments of the mitochondrial (mt) genes cytochrome c oxidase subunit I (COI) and Cytochrome b as

97 EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sen

98 ons: Cox6a2, which codes for an isoform of a cytochrome c oxidase subunit.

99 and genes coding for NADH dehydrogenase and cytochrome c oxidase subunits.

100 gly, yeast, mouse liver, and isolated bovine cytochrome c oxidase were directly inhibited by the drug

101 biopsies, cocoa improved mitochondrial COX (cytochrome c oxidase) activity (P=0.013), increased capi

102 We measured the oxidation state of cytochrome c oxidase, an intracellular measure of metabo

103 In the hypoxic mitochondrion, cytochrome c oxidase, which is a major source of NO, als

104 mtDNA depletion and cytochrome c oxidase-negative cells were found ex vivo i

105 is also utilized in other enzymes, including cytochrome c oxidase.

106 The largest subgroup contains the cytochrome c oxidases (CcO), which reduce molecular oxyg

107 In the absence of high-affinity cytochrome c oxidases, deletion of mhr no longer caused

108 Cytochrome c peroxidase (CcP) employs a Trp191(*+) radic

109 ned in a structurally nonhomologous protein, cytochrome c peroxidase (CcP), by only two mutations (Cu

110 drogen peroxide (H(2)O(2)) respiration using cytochrome c peroxidase (Ccp).

111 eme enzyme that is a member of the bacterial cytochrome c peroxidase superfamily, capable of generati

112 (p.Tyr314Ser) in the mitochondrial ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) gene, whi

113 Ubiquinol-cytochrome c reductase hinge protein (UQCRH) is the hing

114 ter assembly and newly synthesized ubiquinol-cytochrome c reductase Rieske iron-sulfur polypeptide 1

115 In wild-type cells, H(2)O(2) caused cytochrome c release and apoptosis, both of which were p

116 totic signalling downstream of MOMP involves cytochrome c release from mitochondria and subsequent ca

117 Active caspase-6 cleaved Bid to induce cytochrome c release, generating a feedforward loop that

118 d functionally uncouples BAX clustering from cytochrome c release, while knockdown of the Rab5 exchan

119 ncides with mitochondrial BAX clustering and cytochrome c release.

120 ctor Rabex-5 impairs both BAX clustering and cytochrome c release.

121 d via comet assay, CyQuant, annexin V, JC-1, cytochrome C subcellular localization, caspase 3 activat

122 S. oneidensis MR-1 encodes two cytochrome c synthetases (CcmF and SirE) and two apocyto

123 oth c-type cytochromes, cytochrome c (1) and cytochrome c The observed reduction in the steady-state

124 es reducing equivalents for the reduction of cytochrome c to facilitate heme attachment.

125 The limit of detections (LOD) for cytochrome c was 0.5 nM.

126 hat oxidative alphaSyn aggregation scavenges cytochrome c's activity into the formation of amorphous,

127 ic bacterium Rhodobacter sphaeroides lacking cytochrome c(2) as natural electron donor to P(+) (mutan

128 des and Desulfovibrio vulgaris Hildenborough cytochrome c(3)).

129 ns (i.e., myoglobin, carbonic anhydrase, and cytochrome c) could be analyzed by SEC-ESI-MS using diff

130 f hemes through deprotonated histidine (e.g. Cytochrome c).

131 the presence of reactive oxygen species and cytochrome c, a proapoptotic peroxidase that is released

132 l associated molecules, including clusterin, cytochrome C, and HTRA2/OMI.

133 me using "protein charge ladders" of azurin, cytochrome c, and myoglobin.

134 of free reactive oxygen species, rather than cytochrome c, are rate limiting.

135 Tested on cytochrome c, myoglobin, and beta-lactoglobulin cross-li

136 usion rates of 6 Hz are used for analysis of cytochrome c, on a DTIMS Q-TOF similar rates were obtain

137 s hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.

138 he dissociated heme to the protein moiety in cytochrome c, which we assign to the presence of covalen

139 yl arachidonoyl-phospholipids or through the cytochrome c-catalyzed oxidative hydrolysis of the vinyl

140 ochrome c maturation (Ccm) systems with MR-1 cytochrome c.

141 we probe the dynamics of certain regions in cytochrome c.

142 RS) based biosensor for the determination of cytochrome c.

143 led collision-induced unfolding pathways for Cytochrome C.

144 es reducing equivalents for the reduction of cytochrome c.

145 ied by the release of toxic proteins such as cytochrome c.

146 n mitochondrial cytochromes by knocking down cytochrome c/c (1) heme lyase 1 (TgCCHL1), a mitochondri

147 slightly changing the abundance of the other cytochromes c.

148 enes changed (increased transcriptional Bax, cytochrome-c and Apaf-1 and downregulated Bcl-2), wherea

149 etics based on the activity of mitochondrial Cytochrome-C Oxidase (CCO).

150 ed in the electron transfer reaction between cytochrome c1 and c.

151 plex composed of class I and class II c-type cytochromes called NaxLS, which has distinctive biochemi

152 alline STC with a cross-section of about 100 cytochromes could support the anaerobic respiration of a

153 e assessment of the effect in representative cytochromes (CYP3A4 and CYP2D6) demonstrated insignifica

154 or determining the mean distance between the cytochrome (CYT) and flavodehydrogenase (DH) domains of

155 n the steady-state abundances of both c-type cytochromes, cytochrome c (1) and cytochrome c The obser

156 present, including transcription factors and cytochrome family members.

157 we provide evidence of a diminished role of cytochromes in cathodic EET.

158 m oxidation by O(2), as compared to those in cytochromes in solution, potentially allowing for effici

159 Among the most highly abundant of these cytochromes is a unique heterodimeric complex composed o

160 anaerobe, expresses a large number of c-type cytochromes, many of which function as anaerobic reducta

161 ediate redirection of electron flow from the cytochrome-mediated pathway to an alternative oxidase (A

162 lated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic en

163 ate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a larg

164 re for lower jaw skin surface was developed, cytochrome oxidase (CO) was used to label flattened-cut

165 We studied the time course of changes of cytochrome oxidase (CytOx) blob spatial density and blob

166 ue relies on sequencing of the mitochondrial cytochrome oxidase I (COI) 'barcode' gene, which remains

167 Cytochrome oxidase I (COI) mitochondrial DNA sequences w

168 We sequenced a portion of the cytochrome oxidase I gene for 432 gnathiids, collected f

169 educed Thermus thermophilus ba(3) (Tt ba(3)) cytochrome oxidase revealed that O(2) binding was slowed

170 logical, and tracing studies suggest that V2 cytochrome oxidase stripes participate in functionally d

171 stituted with an active proton-translocating cytochrome oxidase, ATP synthesis readily occurred at th

172 eased the activities of citrate synthase and cytochrome oxidase.

173 ay, thereby circumventing the time-dependent cytochrome P (CYP) 450 inhibition observed with the C6-C

174 Directed evolution of genetically encoded cytochrome P411 enzymes (P450s whose Cys axial ligand to

175 onstrated with libraries of randomly mutated cytochrome P411 variants to identify improved catalysts

176 xial ligand has been substituted for serine (cytochrome P411), are fully genetically encoded and prod

177 Previous studies implicate cytochrome P450 (CYP) 2B11 as an important clearance mec

178 We identified rifamycin induced DMEs, cytochrome P450 (CYP) 2C8/3A4/3A5, SULT2A, and UGT1A4/1A

179 chlorinated biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and includes PCB oxidation

180 Toxicokinetic interactions with catabolic cytochrome P450 (CYP) enzymes can inhibit chemical elimi

181 The human cytochrome P450 (CYP) enzymes CYP3A4 and CYP3A5 metaboli

182 Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increa

183 The superfamily of hepatic cytochrome P450 (CYP) enzymes is responsible for the int

184 cyclooxygenase (COX), lipoxygenase (LOX), or cytochrome P450 (CYP).

185 ere we report on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gene cluster that produces a

186 cient in flavodiiron proteins (FLVs) or in a cytochrome p450 (CYP55), we show that FLVs contribute to

187 conversion to leubethanol is catalyzed by a cytochrome P450 (CYP71D616) of the CYP71 clan.

188 This leads to the identification of a cytochrome P450 (CYP728B70) that can catalyze oxidation

189 ple organs and selected supersomes of single cytochrome P450 (cyt P450) enzymes on the magnetic beads

190 usion enzyme comprising two major domains: a cytochrome P450 (heme-binding) catalytic domain and a NA

191 Both enantiomers of this inhibitor of cytochrome P450 (P450) 17A1 show some selectivity in dif

192 Cytochrome P450 (P450) 3A4 is the enzyme most involved i

193 Human cytochrome P450 (P450) CYP2B6 undergoes nitric oxide (NO

194 tin-dependent proteasomal degradation of the cytochrome P450 (P450) enzyme CYP2B6.

195 Aromatase, or cytochrome P450 19A1, catalyzes the aromatization of and

196 The androgen receptor (ar) and cytochrome P450 1A genes were associated with large shif

197 atively by LiMAx test (enzymatic capacity of cytochrome P450 1A2).

198 The mammalian ancestor of the cytochrome P450 1B subfamily was herein characterized st

199 synthesizing and -degrading enzymes, such as cytochrome P450 26 (Cyp26 genes).

200 /central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of r

201 d because of their higher prevalence of poor cytochrome P450 2C19 metabolizers.

202 Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gen

203 Cytochrome P450 2J2 (CYP2J2) is responsible for the epox

204 unds was also tested for metabolism by human cytochrome P450 3A4 (CYP3A4) and human aldehyde oxidase

205 X receptor helped in overcoming a persistent cytochrome P450 3A4 induction problem.

206 de novo donor-specific antibody development, cytochrome P450 3A5 genotype, pregraft sensitization, mo

207 model, based on 666 patients with available cytochrome P450 3A5 genotypes, the effect of the C/D rat

208 Efavirenz (EFV) is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is the major brain choles

209 Cytochrome P450 46A1 (CYP46A1) or cholesterol-24-hydroxy

210 (PPARalpha), which induces transcription of cytochrome P450 4A (CYP4A).

211 oxicity against cancer cell lines expressing cytochrome P450 4F11.

212 Mammary-tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for i

213 nzymes responsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2).

214 rformance (i.e. urea and albumin production, cytochrome P450 activity and induction studies) of the p

215 compared with static organoid cultures, and cytochrome p450 activity reached levels equivalent to he

216 eas imidazole directly kills Mtb by reducing cytochrome P450 activity.

217 ecretion of albumin and apolipoprotein B and cytochrome P450 activity; cholangiocytes were functional

218 achio is likely attributable to the expanded cytochrome P450 and chitinase gene families.

219 to the heme proteins hemoglobin, myoglobin, cytochrome P450 and cytochrome c, respectively.

220 The bacterial cytochrome P450 CYP101B1 from Novosphingobium aromaticiv

221 Here, we report the characterization of the cytochrome P450 enzyme BotCYP from a bottromycin biosynt

222 Screening of a 48-variant library of the cytochrome P450 enzyme CYP102A1 (P450BM3), followed by t

223 The catalysts, derived from a cytochrome P450 enzyme in which the native cysteine axia

224 CYP17A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17

225 ithelium (RPE), TH regulates expression of a cytochrome P450 enzyme, cyp27c1, that converts vitamin A

226 oxyresorufin-O-deethylase (EROD) activity of cytochrome P450 enzymes and continuous accumulation of f

227 Cytochrome P450 enzymes have tremendous potential as ind

228 Mammalian cytochrome P450 enzymes often metabolize many pharmaceut

229 Sterol 14alpha-demethylases (CYP51) are the cytochrome P450 enzymes required for biosynthesis of ste

230 Reconstructed ancestral cytochrome P450 enzymes tend to have variable substrate

231 oat transcriptome data to identify candidate cytochrome P450 enzymes that may catalyse C-21beta oxida

232 report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cycloprop

233 ree kratom alkaloids tested inhibited select cytochrome P450 enzymes, suggesting a potential risk for

234 xidative aromatic cross-linking performed by cytochrome P450 enzymes.

235 ment with 4-phenylimidazole, an inhibitor of cytochrome P450 enzymes.

236 thiolate-heme containing epoxidases, such as cytochrome P450 epoxidases.

237 Cytochrome P450 family 102 subfamily A member 1 (CYP102A

238 The human cytochrome P450 family 11 subfamily B member 2 (hCYP11B2

239 e polymorphism (SNP) rs7175922 in aromatase (cytochrome P450 family 19 subfamily A member 1 [CYP19A1]

240 e previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1)

241 om responding to RA by catabolic activity of cytochrome P450 family 26 enzymes.

242 Cytochrome P450 family 27 subfamily B member 1 (CYP27B1)

243 CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant

244 whereas all genes coding for members of the cytochrome P450 family were upregulated.

245 We studied a cytochrome P450 gene from A. officinalis, AoCYP94B1, and

246 an isoform-specific probe for CYP3A4, a key cytochrome P450 isoform responsible for the oxidation of

247 ,18(S)-Epoxyeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of eicosapentaenoic acid (EPA

248 orest (AUC = 0.83 [0.69, 0.96]), followed by cytochrome p450 metabolites using adaptive elastic-net (

249 Here the first example of a wild-type cytochrome P450 monooxygenase (CYP116B46 from Tepidiphil

250 Additionally, a cytochrome P450 monooxygenase (CYP99A17), which genomica

251 We report that a wild-type cytochrome P450 monooxygenase (P450(BM3) from Bacillus m

252 Cinnamate 4-hydroxylase (C4H; CYP73A) is a cytochrome P450 monooxygenase associated externally with

253 The cytochrome P450 monooxygenase P450 BM3 (BM3) is a biotec

254 They are synthesized by cytochrome P450 monooxygenases (CYPs) and degraded by so

255 Cytochrome P450 monooxygenases (CYPs/P450s), heme thiola

256 Cytochrome P450 monooxygenases (termed CYPs or P450s) ar

257 Direct epoxidation of aromatic nuclei by cytochrome P450 monooxygenases is one of the major metab

258 We also found that cytochrome P450 oxidases involved in cutin and suberin p

259 0.05) following oral THC administration for cytochrome P450 oxidoreductase (Por), involved in toxin

260 n 10 (C10) to a carboxylic group by TcCHH, a cytochrome P450 oxidoreductase.

261 of the mice treated with OCA, the levels of cytochrome P450 potentially involved in VPA metabolism w

262 selectivity versus other PDE enzymes, clean cytochrome P450 profile, in vivo target occupancy, and p

263 The cytochrome P450 proteins contain heme as a cofactor and

264 (heme-binding) catalytic domain and a NADPH-cytochrome P450 reductase (CPR) domain containing FAD an

265 me b5 (B5)/cytochrome b5 reductase (B5R) and cytochrome P450 reductase (CPR) were measured in aortic

266 enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electron

267 The enzyme uses NADPH-cytochrome P450 reductase as a donor of electrons and hy

268 For the past 40 years, my interest has been cytochrome P450 structure-function and structure-activit

269 Notably, we identified a non-canonical cytochrome P450 that catalyses the remarkable ring expan

270 eds led to the identification of CYP88A13, a cytochrome P450 that catalyzes the C-16alpha hydroxylati

271 hydroxylase, thiolate-ligated heme-dependent cytochrome P450, and four nonheme oxygenases, namely, te

272 a candidate gene encoding an uncharacterized cytochrome P450, CYP71A27 Loss of this gene resulted in

273 Common genetic variation in CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19)

274 Genome mining enabled identification of the cytochrome P450, NzeB (Streptomyces sp. NRRL F-5053), wh

275 ural evaluation of a reconstructed ancestral cytochrome P450, revealing key features that appear to c

276 gene expansions in the glycosyltransferase, cytochrome P450, shikimate hydroxycinnamoyl transferase,

277 Cytochrome P450-dependent metabolism of the anti-HIV dru

278 tical review of the evidence for presence of cytochrome P450-mediated metabolic resistance mechanisms

279 nd closure via the upregulation of mtROS and Cytochrome P450.

280 X2 and an increase LMs products of ALOX5 and cytochrome p450.

281 lished enzymes leading to oxidations such as cytochrome P450.

282 been proposed that such chemoresistance via cytochrome P450/drug transporters can be reversed with t

283 Cytochromes P450 (P450, CYP) metabolize a wide variety o

284 Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound

285 The cytochromes P450 are heme-dependent enzymes that catalyz

286 It has become increasingly clear that cytochromes P450 can cycle back and forth between two ex

287 ed structure with those of well-investigated cytochromes P450 from mammals and bacteria enabled us to

288 Cytochromes P450 have been recently identified as a prom

289 51 enzymes (sterol 14alpha-demethylases) are cytochromes P450 that catalyze multistep reactions.

290 rbicide metabolism-based resistances include cytochromes P450, GSH S-transferases, glucosyl and other

291 Expression of cytochrome P4501a (cyp1a) was also measured.

292 production improves subsequent decoration by cytochrome P450s, supporting efficient conversion of (S)

293 is minimized its oxidase activity and b-type cytochrome protein was constructed to realize multiplexe

294 ased the abundance of heme-containing c-type cytochrome proteins in the parasite mitochondrion.

295 Two c-type cytochrome reductases also possess atypical heme-binding

296 ted diphenyl ethers (PBDEs) and induction of cytochrome's P450 (CYP1A1 and CYP2B isoforms) were evalu

297 ated crystalline lattices of Small Tetraheme Cytochromes (STC) forming well-defined, three-dimensiona

298 enases' substrates through quinones and then cytochromes to O(2), these results imply that the site o

299 en revealed to be facilitated through c-type cytochromes, which mediate charge between the electrode

300 genomic database search revealed that c-type cytochromes with a contracted CXCH heme-binding motif ar