ライフサイエンスコーパス: cytolethal

1 The bacterial genotoxins cytolethal distending toxin (CDT) and colibactin cause s

2 Haemophilus ducreyi makes cytolethal distending toxin (CDT) and hemolysin.

3 r actinomycetemcomitans strains that express cytolethal distending toxin (Cdt) are associated with lo

4 tis in susceptible mouse strains, produces a cytolethal distending toxin (CDT) consisting of CdtA, Cd

5 cobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family of bacterial cy

6 activity that represent a new member of the cytolethal distending toxin (CDT) family of bacterial to

7 Cytolethal distending toxin (CDT) from the diarrheagenic

8 ivo experiments, we recently showed that the cytolethal distending toxin (Cdt) from the periodontal p

9 IL-8 secretion was reduced by flagellum and cytolethal distending toxin (CDT) gene mutants, treatmen

10 o determine the role of the virulence factor cytolethal distending toxin (CDT) in the pathogenesis of

11 Cytolethal distending toxin (CDT) induces cell cycle arr

12 The tripartite cytolethal distending toxin (CDT) induces cell cycle arr

13 Cytolethal distending toxin (CDT) is a multisubunit prot

14 Cytolethal distending toxin (CDT) is a newly described t

15 The Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt) is a potent immunotoxi

16 to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon the

17 to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon the

18 The cytolethal distending toxin (Cdt) is produced from a num

19 Because cytolethal distending toxin (CDT) may be a virulence fac

20 The cytolethal distending toxin (Cdt) of Actinobacillus acti

21 The cytolethal distending toxin (CDT) of Actinobacillus acti

22 The cytolethal distending toxin (CDT) of Campylobacter jejun

23 The cytolethal distending toxin (CDT) of Haemophilus ducreyi

24 herichia coli cdtABC genes that comprise the cytolethal distending toxin (CDT) of this enteric pathog

25 Campylobacter jejuni-derived cytolethal distending toxin (CDT) promotes CRC metastasi

26 ith the Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt) results in dose-depend

27 hat the CdtB polypeptide of Escherichia coli cytolethal distending toxin (CDT) shares significant pat

28 Campylobacter jejuni encodes a cytolethal distending toxin (CDT) that causes cells to a

29 egatibacter actinomycetemcomitans produces a cytolethal distending toxin (Cdt) that inhibits the prol

30 Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that is encoded by the

31 Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that kills HeLa, HEp-2

32 A genetic locus for a cytolethal distending toxin (CDT) was identified in a po

33 of 20 Escherichia coli strains that produce cytolethal distending toxin (CDT) were analyzed for thei

34 Moreover, the effects of the cytolethal distending toxin (CDT) were evaluated first b

35 hree membrane-associated protein subunits of cytolethal distending toxin (CDT) were unable to induce

36 cytolethal distending toxin (Cdt), 4',6-diamidino-2-phen

37 Many H. ducreyi strains express cytolethal distending toxin (CDT), and recombinant CDT c

38 The bacterial genotoxin, cytolethal distending toxin (CDT), causes DNA damage in

39 Abbreviations: cytolethal distending toxin (Cdt), connective tissue (CT

40 The cytolethal distending toxin (Cdt), expressed by the peri

41 A genetically modified cytolethal distending toxin (Cdt), from the periodontal

42 ance of potential virulence factors, such as cytolethal distending toxin (CDT), in vivo are poorly un

43 polymorphic regions in the leukotoxin (lkt), cytolethal distending toxin (cdt), major fimbrial subuni

44 The cytolethal distending toxin (Cdt), produced by some clin

45 enic bacteria have evolved a toxin, known as cytolethal distending toxin (CDT), that has the ability

46 athogens encode a multisubunit toxin, termed cytolethal distending toxin (CDT), that induces cell cyc

47 ampylobacter jejuni produces a toxin, called cytolethal distending toxin (CDT), which causes direct D

48 Many bacterial pathogens encode the cytolethal distending toxin (CDT), which causes host cel

49 in survival and pathogenesis, including the cytolethal distending toxin (CDT).

50 They possess virulence factors, such as cytolethal distending toxin (CDT).

51 em, but the genome does not harbor genes for cytolethal distending toxin (cdt).

52 and animals were examined for production of cytolethal distending toxin (Cdt).

53 known heat-labile toxins, a hemolysin and a cytolethal distending toxin (CDT).

54 Campylobacter jejuni produces a toxin called cytolethal distending toxin (CDT).

55 ks), cytotoxic necrotizing factor (cnf), and cytolethal distending toxin (cdt).

56 al adhesion; (b) the newly discovered toxin, cytolethal distending toxin (CDT); and (c) a secreted ch

57 s an immunosuppressive factor encoded by the cytolethal distending toxin (cdt)B gene, which is homolo

58 s an immunosuppressive factor encoded by the cytolethal distending toxin (cdt)B gene.

59 ontains intact homologs of the gene encoding cytolethal distending toxin (cdtB), which interrupts the

60 ed in NBM, notably diarrhea-associated cdtB (cytolethal distending toxin [46%]) and urinary tract inf

61 n a validated rat model of IBS-D (induced by cytolethal distending toxin [CdtB] inoculation).

62 We concluded that cytolethal distending toxin activity is a characteristic

63 Cytolethal distending toxin activity is a potential viru

64 ys for the presence of the cdtB gene and for cytolethal distending toxin activity.

65 ell established, but the association between cytolethal distending toxin and disease is incompletely

66 ecapitulate the evolution of two toxin genes-cytolethal distending toxin B (cdtB) and apoptosis induc

67 , the commercially available version of anti-cytolethal distending toxin B and anti-vinculin antibodi

68 -terminal Cys residue, a CdtB homologue from cytolethal distending toxin can form a functional comple

69 ni and Campylobacter coli, the production of cytolethal distending toxin correlated positively (P < 0

70 Intoxication by cytolethal distending toxin depends on assembly of CdtB,

71 CR quantitation of the H. hepaticus-specific cytolethal distending toxin gene and showed similar anim

72 Sequence analysis of the cytolethal distending toxin gene cluster (cdt) also disc

73 e demonstrated the role of LuxS in motility, cytolethal distending toxin production, agglutination, a

74 , type 6 secretion system needle protein, or cytolethal distending toxin revealed a direct correlatio

75 erial genes encoding toxins of animal cells, cytolethal distending toxin subunit B (cdtB) and apoptos

76 The presence of cytolethal distending toxin was confirmed on the basis o

77 (M fimbriae), gafD (G fimbriae), cnf1, cdtB (cytolethal distending toxin), cvaC (colicin V), and ibeA

78 gene (encoding subunit B of the H. hepaticus cytolethal distending toxin).

79 so identified genes needed for the action of cytolethal distending toxin, including a cell-surface pr

80 a new diagnostic assay: hemolysin E (HlyE), cytolethal distending toxin, S. Typhi lipopolysaccharide

81 tB, a homologue of the active subunit of the cytolethal distending toxin, which causes DNA damage lea

82 i (7.9%), cell-detaching E. coli (6.9%), and cytolethal distending toxin-producing E. coli (0.9%).

83 Overall the pathotypes, apart from cytolethal distending toxin-producing E. coli, were reco

84 ell vacuoles and induces apoptotic death via cytolethal distending toxin.

85 ll as live bacteria and do not depend on the cytolethal distending toxin.

86 Abbreviations: Cdt, cytolethal distending toxin; CSC, cancer stem cells; HNS

87 dtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed by several

88 dtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed by several

89 e, one of three genes encoding the family of cytolethal distending toxins (Cdt).

90 Cytolethal distending toxins (CDTs) are multisubunit pro

91 Cytolethal distending toxins (CDTs) are tripartite prote

92 Cytolethal distending toxins (CDTs) block cell division

93 The cytolethal distending toxins (CDTs) compose a subclass o

94 creens as illustrated here for the family of cytolethal distending toxins (CDTs).

95 Cytolethal distending toxins are produced by a small but

96 e genomic island that carries genes encoding cytolethal distending toxins.

97 nternalized by the Acanthamoeba predator are cytolethal; the presence of purified Dtx or Stx in cultu

98 warhead to CTA1, thus converting CTx into a cytolethal toxin.