ライフサイエンスコーパス: cytolysin

1 O (PFO) is a sterol-dependent, pore-forming cytolysin.

2 y increasing expression of MCP-1, MCP-3, and cytolysin.

3 faecalis produce a two-subunit toxin, termed cytolysin.

4 ross-resistant to nisin and the pAD1-encoded cytolysin.

5 treptolysin O (SLO), a cholesterol-dependent cytolysin.

6 sceptible to the bactericidal effects of the cytolysin.

7 serum passaged to enhance the production of cytolysin.

8 es, demonstrating the possible presence of a cytolysin.

9 le cytotoxic component, possibly a hemolytic cytolysin.

10 l cell resilience to a cholesterol-dependent cytolysin.

11 ivity of the fungus sensitized host cells to cytolysin.

12 onent lantibiotic homologous to enterococcal cytolysin.

13 d, but inactive, lectin from Vibrio cholerae cytolysin.

14 (PFO), a pore-forming cholesterol-dependent cytolysin.

15 density by perfringolysin O, a pore-forming cytolysin.

16 elong to the family of cholesterol-dependent cytolysins.

17 e repeats-in-toxin (RTX) family of bacterial cytolysins.

18 rotected cells against cholesterol-dependent cytolysins.

19 uding the well-studied cholesterol-dependent cytolysins.

20 ing cholesterol protects cells against these cytolysins.

21 bacteria that secrete cholesterol-dependent cytolysins.

22 lular survival against cholesterol-dependent cytolysins.

23 erved for perforin and cholesterol-dependent cytolysins.

24 ell death through the action of pore-forming cytolysins.

25 ulatory proteins and increased expression of cytolysins.

26 Cytolysin A (ClyA) is an alpha-pore forming toxin from p

27 The alpha-pore-forming toxin Cytolysin A (ClyA) is responsible for the hemolytic acti

28 ein (tCSP) fused to Salmonella serovar Typhi cytolysin A (ClyA) were constructed as a first step in t

29 g enzyme properties, in this work we evolved Cytolysin A from Salmonella typhi (ClyA) to a high level

30 ibe the cryptic chromosomally encoded 34-kDa cytolysin A hemolysin of Salmonella enterica serovar Typ

31 s the structural gene for the GBS haemolysin/cytolysin, a novel bacterial toxin.

32 the prototype for the cholesterol-dependent cytolysins, a family of bacterial pore-forming toxins th

33 Here we identify cytolysin-a two-subunit exotoxin that is secreted by Ent

34 pyolysin was partially dependent on reducing cytolysin-accessible cholesterol in the cell membrane an

35 We unveil early steps in NLP cytolysin action that determine plant clade-specific tox

36 rate that cytolysin immunity is unrelated to cytolysin activator (CylA) expression as previously prop

37 ogens, many of which exhibit pore-forming or cytolysin activity

38 infections, exhibit decreased beta-hemolysin/cytolysin activity, and show increased sensitivity to au

39 netic locus encoding the GBS beta-haemolysin/cytolysin activity.

40 etic locus (cyl) required for GBS haemolysin/cytolysin activity.

41 ate that another group of virulence factors, cytolysins, aid in the penetration of superantigens acro

42 of cholesterol detectable with the modified cytolysin ALO-D4) but not in sphingolipid-sequestered ch

43 toxins are the membrane-active pore-forming cytolysin alpha-toxin (Hla) and the amphipathic alpha-he

44 The staphylococcal cytolysin alpha-toxin and the streptococcal cytolysin st

45 ere proinflammatory, only the staphylococcal cytolysin alpha-toxin induced a strong immune response f

46 otoxins B and C, and enterotoxin-like X) and cytolysins (alpha-, beta-, and gamma-toxins) and challen

47 virulence were produced by both strains, and cytolysins (alpha-toxin and gamma-toxin), superantigens,

48 rated decreased expression of beta-hemolysin/cytolysin, an important cytotoxin implicated in facilita

49 ked increase in production of beta-hemolysin/cytolysin and a striking decrease in production of CAMP

50 To delineate the contributions of the cytolysin and lectin domains in pore formation, we used

51 Fur coordinates the reciprocal expression of cytolysins and a subset of immunomodulatory proteins.

52 ) family of proteins classically consists of cytolysins and hemolysins.

53 e microscopy images of cholesterol-dependent cytolysins and related proteins that form large pores in

54 ock hemolytic activity, reduce the amount of cytolysin, and attenuate expression of the cytolysin bio

55 ar chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzyme

56 Increased damage is mediated by enterococcal cytolysin, and involves both physical interaction and al

57 Cholesterol-dependent cytolysins are a family of poreforming proteins that hav

58 , fsr, a putative quorum-sensing system, and cytolysin, are also important for nematode killing.

59 ember of the family of cholesterol-dependent cytolysins because it binds to human CD59 (hCD59) rather

60 f group B Streptococcus (GBS) beta-hemolysin/cytolysin (beta h/c) in a neonatal-rabbit model of GBS p

61 Production of a beta-hemolysin/cytolysin (beta-h/c) encoded by the cylE gene is associa

62 ranscription of a cytotoxin, beta-haemolysin/cytolysin (beta-H/C) that is critical for survival of GB

63 sion and the GBS pore-forming beta-hemolysin/cytolysin (beta-h/c) trigger autophagic activation.

64 nd related factors, including beta-hemolysin/cytolysin (beta-h/c), surface-anchored adhesin HvgA, and

65 rs including the pluripotent beta-haemolysin/cytolysin (beta-H/C).

66 The pore-forming GBS beta-hemolysin/cytolysin (betaH/C) encoded by cylE is an important viru

67 ution of the pore-forming GBS beta-hemolysin/cytolysin (betaH/C) to vaginal colonization, ascension,

68 f cytolysin, and attenuate expression of the cytolysin biosynthetic gene cluster without impeding cel

69 resembles those of the cholesterol-dependent cytolysins but is distinct from that recently proposed f

70 steine protease and the streptolysin O (SLO) cytolysin, but not SIC, a protein that protects S. pyoge

71 asis of a model for the autoinduction of the cytolysin by a quorum-sensing mechanism involving a two-

72 Pore formation itself was examined for both cytolysins by encapsulating fluorescein-labeled peptides

73 rforation by bacterial cholesterol-dependent cytolysins, calcium influx activates mixed lineage kinas

74 acterial pathogen secreting a human-specific cytolysin called intermedilysin (ILY) as a major pathoge

75 llular pathogen that secretes a pore-forming cytolysin called listeriolysin O (LLO), which disrupts t

76 Intermedilysin (ILY) has been shown to be a cytolysin capable of generating pores in the cell membra

77 Chiral GC-MS analysis revealed that, like cytolysin, carnolysin contained lanthionine and methylla

78 Upon histological examination, both cytolysins caused damage to the uppermost layers of the

79 Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pn

80 e-forming toxin of the cholesterol-dependent cytolysin (CDC) family and a primary virulence factor of

81 FO) is a member of the cholesterol-dependent cytolysin (CDC) family of membrane-penetrating toxins.

82 (PLY), a member of the cholesterol-dependent cytolysin (CDC) family, is a major S. pneumoniae virulen

83 hat is a member of the cholesterol-dependent cytolysin (CDC) family, most closely related to intermed

84 racis, a member of the cholesterol-dependent cytolysin (CDC) family, which includes listeriolysin O,

85 (ALO), a member of the cholesterol-dependent cytolysin (CDC) family.

86 ctivity encoded by the cholesterol-dependent cytolysin (CDC) listeriolysin O (LLO) acts within the in

87 The assembly of the cholesterol-dependent cytolysin (CDC) oligomeric pore complex requires a compl

88 The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence fac

89 LO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis, the etio

90 Pneumolysin is a cholesterol-dependent cytolysin (CDC) toxin that forms lytic pores in host mem

91 plex/perforin (MACPF), cholesterol-dependent cytolysin (CDC), and gasdermin superfamilies, which all

92 (ILY), a pore forming cholesterol-dependent cytolysin (CDC), specifically binds to human CD59 (hCD59

93 nosis (BV), produces a cholesterol-dependent cytolysin (CDC), vaginolysin (VLY).

94 ivities of the related cholesterol-dependent cytolysins (CDC), pneumolysin and streptolysin.

95 The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxi

96 Cholesterol-dependent cytolysins (CDCs) are a large family of bacterial toxins

97 The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming tox

98 Cholesterol-dependent cytolysins (CDCs) are a subclass of PFTs widely implicat

99 Cholesterol-dependent cytolysins (CDCs) are pore-forming proteins that serve a

100 Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by ba

101 The cholesterol-dependent cytolysins (CDCs) are pore-forming toxins that have been

102 Cholesterol-dependent cytolysins (CDCs) are secreted, pore-forming toxins that

103 mechanism by which the cholesterol-dependent cytolysins (CDCs) assemble their giant beta-barrel pore

104 Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-formin

105 Cholesterol-dependent cytolysins (CDCs) constitute the largest group of pore-f

106 The pore-forming cholesterol-dependent cytolysins (CDCs) contribute to the pathogenic mechanism

107 rming mechanism of the cholesterol-dependent cytolysins (CDCs) exhibits an absolute requirement for m

108 haracterized bacterial cholesterol-dependent cytolysins (CDCs) is not detectable by sequence analysis

109 f domain 4 (D4) of the cholesterol-dependent cytolysins (CDCs) mediate the binding of the CDC monomer

110 Cholesterol-dependent cytolysins (CDCs) represent a family of homologous pore-

111 Pore formation by the cholesterol-dependent cytolysins (CDCs) requires the presence of cholesterol i

112 The majority of cholesterol-dependent cytolysins (CDCs) utilize cholesterol as a membrane rece

113 PLY is a member of the cholesterol-dependent cytolysins (CDCs), a family of pore-forming toxins that

114 ch as perforin and the cholesterol-dependent cytolysins (CDCs), all of which require the membrane for

115 (Ply), a member of the cholesterol-dependent cytolysins (CDCs), is produced by virtually all clinical

116 ve bacteria depends on cholesterol-dependent cytolysins (CDCs), which form pores in eukaryotic cell p

117 bacterial pore-forming cholesterol-dependent cytolysins (CDCs).

118 family of pore-forming cholesterol-dependent cytolysins (CDCs).

119 ember of the bacterial cholesterol-dependent cytolysins (CDCs).

120 The cytolysin consists of two structural subunits, CylLL and

121 ral administration of IgY antibodies against cytolysin decreased ethanol-induced liver disease in gno

122 However, coproduction of gelatinase and cytolysin did not increase virulence additively, account

123 Apart from the cytolysin domain, VCC harbors two lectin-like domains: t

124 he binding of modified versions of bacterial cytolysins (e.g., anthrolysin O).

125 e binding and pore formation of a eukaryotic cytolysin, Equinatoxin II (EqtII).

126 Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an i

127 iption of genes important for beta-hemolysin/cytolysin expression and export is similar to the wild t

128 An understanding of conditions that regulate cytolysin expression has advanced little since its initi

129 Cytolysin expression is regulated by one of the subunits

130 serine hydroxamate increased beta-hemolysin/cytolysin expression.

131 or the function of the cholesterol-dependent cytolysin family and its wide distribution suggests that

132 pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins.

133 (PFO), a member of the cholesterol-dependent cytolysin family of pore-forming toxins, forms large oli

134 l other members of the cholesterol-dependent cytolysin family, Ply lacks a signal peptide for export.

135 Bacterial repeats in toxin (RTX) cytolysins form a prominent group of proteins that are s

136 fringolysin O (PFO), a cholesterol-dependent cytolysin, forms large oligomeric pore complexes compris

137 in O, the prototypical cholesterol-dependent cytolysin from Clostridium perfringens.

138 pproach, we generated IgY antibodies against cytolysin from hyperimmunized chickens.

139 h pyolysin, which is a cholesterol-dependent cytolysin from Trueperella pyogenes that targets these e

140 68.4% similarity), the cholesterol-dependent cytolysins from Streptococcus intermedius and Gardnerell

141 vided into (1) control of metabolism and PSM cytolysin genes, which occurs independently of the small

142 n, work together to repress transcription of cytolysin genes.

143 tant with the influx of cells expressing the cytolysins granzymes A and B.

144 ed multicenter cohort, the presence of fecal cytolysin has a better diagnostic area under the curve,

145 forin (also known as pore-forming protein or cytolysin), has been shown to be capable of undergoing p

146 Vibrio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa beta-

147 s, and the localization of one of these (the cytolysin/hemolysin) to the periplasmic space indicates

148 ase (AC) domain linked to a pore-forming RTX cytolysin (Hly) moiety, binds the complement receptor 3

149 A novel cytolysin immunity determinant at the 3' end of the pAD1

150 fic mutagenesis experiments demonstrate that cytolysin immunity is unrelated to cytolysin activator (

151 Cytolysin immunity is, however, encoded on the same tran

152 llows the organism to express high levels of cytolysin in response.

153 We found that these bacteriophages decrease cytolysin in the liver and abolish ethanol-induced liver

154 odel studies have established a role for the cytolysin in the pathogenesis of enterococcal disease.

155 en immunoglobulin Y (IgY) antibodies against cytolysin in vitro and in a microbiota-humanized mouse m

156 of the known roles of cholesterol-dependent cytolysins in disrupting calcium gradients and inducing

157 suilysin, a member of cholesterol-dependent cytolysins, in differential pathogenicity between ST1 an

158 ing IgY antibodies against cytolysin reduced cytolysin-induced cell death in primary mouse hepatocyte

159 l route to the development of treatments for cytolysin-induced disease states.

160 e to perfringolysin O transformed this toxic cytolysin into a nontoxic derivative that facilitated in

161 were sufficient to convert an extracellular cytolysin into a vacuole-specific lysin which mediated g

162 The enterococcal cytolysin is a toxic, two-component ribosomally synthesi

163 The enterococcal cytolysin is a virulence factor consisting of two post-t

164 E. faecalis cytolysin is an important mortality predictor in alcohol

165 In addition to its toxin activity, the cytolysin is bactericidal for nearly all Gram-positive o

166 However, unlike lantibiotics, the cytolysin is lytic for eukaryotic as well as prokaryotic

167 ion reactions during the biosynthesis of the cytolysin large subunit.

168 known facet of BV-the presence of bacterial cytolysins-leads to mobilization of intracellular conten

169 mouse-derived cells tested, the pore-forming cytolysin listeriolysin O (LLO) is absolutely required f

170 tion factor PrfA, including the pore-forming cytolysin listeriolysin O (LLO), two phospholipases C (P

171 to the cytosol by secreting the pore-forming cytolysin listeriolysin O (LLO).

172 irulence gene hly (encoding the pore-forming cytolysin listeriolysin) is under negative regulation by

173 The pore-forming cholesterol-dependent cytolysin, listeriolysin O (LLO), mediates bacterial esc

174 lular pathogen which secretes a pore-forming cytolysin, listeriolysin O (LLO), necessary for intracel

175 escapes from the phagosome using a secreted cytolysin, listeriolysin O (LLO).

176 The invertebrate cytolysin lysenin is a member of the aerolysin family of

177 ttack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superf

178 ttack Complex-Perforin/Cholesterol-Dependent Cytolysin (MACPF/CDC) superfamily.

179 cids are designed and synthesized that block cytolysin maturation at low micromolar to nanomolar conc

180 ins produced by many Gram-positive bacteria, cytolysin-mediated evasion of lysosomal killing may be a

181 Cytolysin-mediated translocation (CMT) is a recently des

182 mily and its wide distribution suggests that cytolysin-mediated translocation (CMT) may be the equiva

183 The mechanism by which the cytolysin-mediated translocation (CMT) pathway of the Gr

184 Cytolysin-mediated translocation (CMT), performed by Str

185 A recent model for cytolysin-mediated translocation in Streptococcus pyogen

186 ripts encoding virulence factors involved in cytolysin-mediated translocation of NAD-glycohydrolase,

187 e cytosol of an infected host cell using the cytolysin-mediated translocation pathway.

188 e cluster was also present in gelatinase-and-cytolysin-negative strain E. faecalis JH2-2.

189 The cytolysin of E. faecalis is a novel bacterial toxin that

190 Listeriolysin O (LLO), a cholesterol-binding cytolysin of Listeria monocytogenes, exhibits cytokine-i

191 Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammat

192 Insensitivity to NLP cytolysins of monocot plants may be explained by the len

193 munity determinant at the 3' end of the pAD1 cytolysin operon is described in the present study.

194 The cholesterol-dependent cytolysin Perfringolysin O (PFO) constitutes a powerful

195 The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostrid

196 r of the pore-forming, cholesterol-dependent cytolysin perfringolysin O (PFO).

197 ble" to binding by a modified version of the cytolysin perfringolysin O (PFO*), whereas another pool

198 racellular pathogen which secretes a related cytolysin, perfringolysin O (PFO).

199 The enterococcal, conjugative, cytolysin plasmid pAD1 confers a mating response to the

200 The pneumococcal cytolysin pneumolysin (PLY) is a major virulence determi

201 Here we identify the cholesterol-dependent cytolysin pneumolysin as a pro-endocytotic factor in lys

202 red blood cells to the cholesterol-dependent cytolysin pneumolysin, a key virulence factor of Strepto

203 The presence of cytolysin-positive (cytolytic) E. faecalis correlated wi

204 previous findings that the presence of fecal cytolysin-positive E. faecalis predicted 180-day mortali

205 tudy were to confirm the predictive value of cytolysin-positive Enterococcus faecalis ( E. faecalis )

206 We previously associated cytolysin-positive Enterococcus faecalis with severity o

207 n gnotobiotic mice colonized with stool from cytolysin-positive patients with alcohol-associated hepa

208 f pneumolysin (Ply), a cholesterol-dependent cytolysin produced by pneumococcus.

209 d expressed recombinant vaginolysin (VLY), a cytolysin produced by the BV-associated bacterium Gardne

210 eptolysin O (SLO) is a cholesterol-dependent cytolysin produced by the important human pathogen, grou

211 LO is the prototype of cholesterol-dependent cytolysins produced by many Gram-positive bacteria, cyto

212 Cytolysin-producing (C+) E. faecalis resides in the gut

213 irulence traits revealed that gelatinase and cytolysin production accounted for 40.8% and 36.5% of th

214 mammals by secreting a cholesterol-dependent cytolysin, pyolysin (PLO), which targets stromal cells.

215 e damage caused by the cholesterol-dependent cytolysin, pyolysin.

216 , two aminopeptidases, TagA-related protein, cytolysin, RbmC, three hypothetical proteins encoded by

217 In addition to its well-recognized role as a cytolysin, recent evidence has indicated that SLS may in

218 Neutralizing IgY antibodies against cytolysin reduced cytolysin-induced cell death in primar

219 neuroinflammation, and its enhancement by a cytolysin represents a proinflammatory control mechanism

220 ccination against secreted superantigens and cytolysins resulted in protection of 86 of 88 rabbits wh

221 een SLO and homologous cholesterol-dependent cytolysins revealed that membrane binding by SLO is nece

222 ingolysin O (PFO), a water-soluble monomeric cytolysin secreted by pathogenic Clostridium perfringens

223 in peptidase required for pilus assembly and cytolysin secretion in V. vulnificus.

224 Mutation of the genes encoding the cytolysin ShlA and its transporter ShlB resulted in atte

225 ct was further narrowed down to the secreted cytolysin ShlA and the biologically active pigment prodi

226 ophage apoptosis induced by the pore-forming cytolysin SLO contributes to GAS immune evasion and viru

227 ed toxin studies identified the pore-forming cytolysin streptolysin O (SLO) as necessary and sufficie

228 es, which utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+)

229 pyogenes, utilizes the cholesterol-dependent cytolysin Streptolysin O (SLO) to translocate the NAD(+)

230 cytolysin alpha-toxin and the streptococcal cytolysin streptolysin O enhanced penetration of toxic s

231 GAS virulence factors, including the potent cytolysin streptolysin S.

232 e, including the immunity factor IFS and the cytolysin (streptolysin O [SLO]), were more abundant in

233 The GAS cholesterol-dependent cytolysin, Streptolysin O (SLO), has well established ce

234 cells against another cholesterol-dependent cytolysin, streptolysin O, and protected lung epithelial

235 the purification and characterization of the cytolysin subunits and detection of lanthionine-type pos

236 Genetic evidence also suggests that the cytolysin subunits are related to the rapidly growing cl

237 s at a specific cell density when one of the cytolysin subunits reaches an extracellular threshold co

238 atively results from cleavage of one or both cytolysin subunits.

239 Cytolysins, superantigens, and proteases were identified

240 30 to 40% identity with the thiol-activated cytolysins (TACYs) of a number of gram-positive bacteria

241 nterococcus faecalis more commonly produce a cytolysin than do commensal isolates.

242 rococcus faecalis produce an exotoxin called cytolysin that contributes to bacterial virulence.

243 streptococci (GBS) express a beta-haemolysin/cytolysin that contributes to disease pathogenesis.

244 eriolysin O (LLO) is a cholesterol-dependent cytolysin that is an essential virulence factor of Liste

245 Listeriolysin O (LLO) is a pore-forming cytolysin that mediates lysis of L. monocytogenes-contai

246 Intermedilysin is a cholesterol-dependent cytolysin that requires the human immune receptor CD59,

247 B) belongs to a large family of pore-forming cytolysins that execute inflammatory cell death programs

248 olysaccharide capsule and the beta-hemolysin/cytolysin toxin (beta-h/c).

249 It produces a cholesterol-dependent cytolysin, vaginolysin (VLY).

250 Vibrio cholerae cytolysin (VCC) is a beta-barrel pore-forming toxin (bet

251 Vibrio cholerae cytolysin (VCC) is a potent membrane-damaging beta-barre

252 Vibrio cholerae cytolysin (VCC) is a potent membrane-damaging cytolytic

253 Vibrio cholerae cytolysin (VCC) is a prominent member in the family of b

254 Vibrio cholerae cytolysin (VCC) is a toxin secreted by the human pathoge

255 Vibrio cholerae cytolysin (VCC) is a water-soluble, membrane-damaging, p

256 re of the 450-kDa heptameric Vibrio cholerae cytolysin (VCC) toxin purified and crystallized in the p

257 thogenic Vibrio cholerae secrete V. cholerae cytolysin (VCC), an 80 kDa pro-toxin that assembles into

258 ae secretes a pore-forming toxin, V.cholerae cytolysin (VCC), which contains two domains that are str

259 To potentially combat cytolysin virulence, we report inhibitors of its maturat

260 acterized strain expressing the enterococcal cytolysin was found to be detrimental to Drosophila comp

261 Carnolysin, unlike cytolysin, was shown to contain d-alanine and unpreceden

262 er expression of their cholesterol-dependent cytolysins when co-resident with Lactobacillus spp. and

263 The active cytolysin, when compared with heat-inactivated ILY, did

264 Here we show that superantigens and cytolysins, when used in vaccine cocktails, provide prot

265 nriched for the expression of a known toxin, cytolysin, which is plasmid encoded.

266 We have detected a cholesterol-dependent cytolysin, which we have named mitilysin, in a small num

267 e tissues by secreting cholesterol-dependent cytolysins, which form pores in the plasma membranes of

268 teria on host cells, facilitating contact of cytolysin with host cells.