ライフサイエンスコーパス: cytoplasmic loop

1 ia the calmodulin binding motif in the third cytoplasmic loop.

2 cated near the ATP binding site in the major cytoplasmic loop.

3 conserved domain (FHIPEP) within a putative cytoplasmic loop.

4 sence of a 29-amino acid insert in the third cytoplasmic loop.

5 kinase A sites and a His-rich region in its cytoplasmic loop.

6 y mutating several glutamate residues in its cytoplasmic loop.

7 ly unappreciated function of the interdomain cytoplasmic loop.

8 al cells via a mechanism involving the third cytoplasmic loop.

9 on were dependent on the length of the third cytoplasmic loop.

10 oteolysis of presenilin-1 in the TM6 --> TM7 cytoplasmic loop.

11 specifically by ubiquitination in the first cytoplasmic loop.

12 CFP or YFP at position 266 within the large cytoplasmic loop.

13 nctional role of ubiquitination in the first cytoplasmic loop.

14 ptor, toward the amino terminus of the third cytoplasmic loop.

15 n NqrC and NqrB the flavins are located in a cytoplasmic loop.

16 the Na(+),K(+)-ATPase in vitro on its large cytoplasmic loop.

17 ing forms dimers mediated by the c subunits' cytoplasmic loops.

18 ne helices framing three periplasmic and two cytoplasmic loops.

19 ining single reactive cysteine groups in the cytoplasmic loops.

20 ting of CD4 fused to the muscle AChR subunit cytoplasmic loops.

21 tructure and proximity of that region to the cytoplasmic loops.

22 may support proximity of the R domain to the cytoplasmic loops.

23 y inactivate AmtB, as do some lesions in its cytoplasmic loops.

24 t)alpha(340-350) blocks acetylation sites on cytoplasmic loops 1, 2, and 4 of Rh*.

25 A short well-defined helix in cytoplasmic loop 2, not observed in either rhodopsin or

26 d cytoplasmic loop, and chymotrypsin cleaved cytoplasmic loops 2 and 3.

27 Here, Lys-946 of cytoplasmic loop 3 (CL3) is proposed as counter-ion of A

28 rved among ABCC4 orthologs and is located in cytoplasmic loop 3 (CL3), we investigated the impact of

29 Similarly, a K978C mutation from cytoplasmic loop 3 (CL3), which promotes ATP-independent

30 was facilitated by the T4 lysozyme fusion in cytoplasmic loop 3 and the considerable stabilisation co

31 ces for divergent residues from the N-ED and cytoplasmic loop 3 had augmented coreceptor activity in

32 ith outwardly facing hydrophilic residues of cytoplasmic loop 3 regulating channel gating.

33 rm a putative hydrogen bond with His(950) of cytoplasmic loop 3 to prevent channel opening by ATP in

34 n energy for denaturation was decreased when cytoplasmic loop 3 was cleaved by papain or chymotrypsin

35 ellular domain (N-ED) and at the junction of cytoplasmic loop 3.

36 released full-length transmembrane helix 1, cytoplasmic loop 6-7, and the long cytoplasmic C terminu

37 the digestion of the COOH- terminal tail or cytoplasmic loop 8 of Sec61alpha.

38 were located in TM-5, -8, -10, or -11 or in cytoplasmic loop 8-9 or loop 10-11.

39 n the central interdomain loop, and A270V in cytoplasmic loop 8-9, restored a wild type level of resi

40 umenal/extracellular domains or shortening a cytoplasmic loop abolishes transport activity by both NP

41 sociation between Cx43CT and a region of the cytoplasmic loop (amino acids 119-144; referred to as "L

42 However, a p7 chimera with 2a TMDs and cytoplasmic loop and 1a tails was viable.

43 A mutant with 2a tails and cytoplasmic loop and 1a TMDs also was not viable.

44 uplings connected the motif to the conserved cytoplasmic loop and adjacent segments.

45 te for factor Xa protease within the central cytoplasmic loop and by eliminating the site of N-linked

46 n G alpha(s) interacts with both the central cytoplasmic loop and C-terminal tail of adenylyl cyclase

47 of G alpha(s) may bring together the central cytoplasmic loop and C-terminal tail of adenylyl cyclase

48 232) production was independent of the third cytoplasmic loop and carboxyl-terminal tail, both the si

49 OAMB-K3 and OAMB-AS), differing in the third cytoplasmic loop and downstream sequence.

50 yptic digestion of hCTR1 occurred within the cytoplasmic loop and generated a 10-Da carboxyl-terminal

51 s Asn203 and Asn276, located in a 12-residue cytoplasmic loop and helix 7, respectively, would not be

52 nts within exons encoding a large C-terminal cytoplasmic loop and in the C-terminal nucleotide-bindin

53 etected with deletion mutations in the third cytoplasmic loop and in the cytoplasmic tail.

54 ected a changed interaction between the ExbB cytoplasmic loop and one or more unknown growth-regulato

55 (249-348)), a fragment composed of the third cytoplasmic loop and sixth transmembrane helix (HF(233-2

56 d at position Cys-79 at the end of the first cytoplasmic loop and the beginning of transmembrane heli

57 In contrast, both the major cytoplasmic loop and the fourth transmembrane domain of

58 e residues to alanines in the putative third cytoplasmic loop and truncation of the C-terminal tail d

59 Whereas rhodopsin contains 11 lysines, 8 in cytoplasmic loops and 1 each in the C-terminal peptide s

60 helix receptor rhodopsin have implicated the cytoplasmic loops and carboxyl-terminal region in the bi

61 that occupies a central position between the cytoplasmic loops and occludes the key binding sites of

62 None of the other cytoplasmic loops and termini of the channel are phospho

63 , non-phosphorylated Mep2 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occ

64 The cytoplasmic loops and the C-terminal tail, containing th

65 by inserting fragments corresponding to the cytoplasmic loops and/or the carboxyl-terminal tail of b

66 the absence of the ATPase is located in the cytoplasmic loop, and (ii) release of pilin from the IM

67 carboxyl terminus and a portion of the third cytoplasmic loop, and chymotrypsin cleaved cytoplasmic l

68 ing motifs (AIMs) located at the C-terminus, cytoplasmic loop, and within the transmembrane segments.

69 , 3 large and 4 small luminal loops, 6 small cytoplasmic loops, and a cytoplasmic tail.

70 ily in the carboxyl terminus but also in the cytoplasmic loops, and subsequent binding of arrestins.

71 man, rat and mouse mRNA that encodes the 2nd cytoplasmic loop are conserved in the zebrafish transcri

72 The findings suggest that the longer cytoplasmic loops are highly flexible and interact in a

73 d have suggested that sites on the rhodopsin cytoplasmic loops are involved in this interaction.

74 Cytoplasmic loops are known to have functional significa

75 domains, which are located in the two large cytoplasmic loops, are highly conserved and well studied

76 proline-rich PEST-like sequence in the first cytoplasmic loop (Asp570-Pro571, GluR3salpha).

77 suggests that the region at the interface of cytoplasmic loop b and transmembrane segment 2 is import

78 extracellular loops a, c, e, g, i, and k and cytoplasmic loops b, d, f, h, and j.

79 rmease fragments with a discontinuity in the cytoplasmic loop between helices II and III (loop II/III

80 h two tandem factor Xa protease sites in the cytoplasmic loop between helices IV and V, it is shown h

81 nvolved in substrate binding, as well as the cytoplasmic loop between helices IV and V.

82 -subunit sequences and is found in the major cytoplasmic loop between M4 and M5, a region previously

83 A 138-amino acid cytoplasmic loop between repeats II and III of the alpha

84 as nine transmembrane segments, with a large cytoplasmic loop between the fifth and sixth transmembra

85 In addition, there is a large cytoplasmic loop between the first and second TMDs, with

86 3-codon deletion (beta426delEQE) in the long cytoplasmic loop between the M3 and M4 domains, curtails

87 of two arginine residues located in a short cytoplasmic loop between TM1 and TM2 (loop-1) showed a d

88 utation of His-444 in TM12 or His-413 in the cytoplasmic loop between TM10 and TM11 was without effec

89 al arrangement of hDKp and indicate that the cytoplasmic loop between TMDs 11-12, containing the crit

90 avage at an engineered site in the predicted cytoplasmic loop between transmembrane (TM) domains 6 an

91 nt with that, a large proportion of the ExbB cytoplasmic loop between transmembrane domain 1 (TMD1) a

92 rminus of SNG-1 and a single arginine in the cytoplasmic loop between transmembrane domain 2 and 3 th

93 almitate determined that the cysteine in the cytoplasmic loop between transmembrane domains 1 and 2 (

94 the GLUT4 amino-terminal domain or the large cytoplasmic loop between transmembrane domains 6 and 7 r

95 itutions were made for 15 amino acids in the cytoplasmic loop between transmembrane helices 6 and 7 (

96 egion (amino acids 371-508) within the large cytoplasmic loop between transmembrane segments 5 and 6.

97 These results indicate that the cytoplasmic loop between transmembrane spans 3 and 4 of

98 The major cytoplasmic loop (between TM4 and TM5), which we have pr

99 There is a large cytoplasmic loop, between the fourth and fifth transmemb

100 motif (L314A, L315A) present in the receptor cytoplasmic loop blocked PMA-stimulated receptor endocyt

101 arriers of missense mutations located in the cytoplasmic loops (C loops), membrane-spanning domain, C

102 nal half of the helical hairpin structure in cytoplasmic loop C1 is important for the activity of Yid

103 rious interaction regions within the central cytoplasmic loop (C1) and the C-terminal tail (C2) on ba

104 ting signal is added to the receptor's first cytoplasmic loop, catalyzed by the Smurf2 ubiquitin liga

105 30 disease-associated missense mutations in cytoplasmic loops caused retention of the nascent polype

106 teractions of the carboxyl-terminus (CT) and cytoplasmic loop (CL) domains underlie voltage- and low

107 localized interactions to the C terminus and cytoplasmic loop (CL)-3, but not CL-1 or CL-2.

108 en both nucleotide binding domains (NBD) and cytoplasmic loops (CL) in opposite halves of the protein

109 the nucleotide binding domains (NBD) and the cytoplasmic loops (CL) of the membrane-spanning domains

110 quence of residues 60-75, which includes the cytoplasmic loop CL1 and cytoplasmic ends of helices TM1

111 nteraction between the surface of NBD1 and a cytoplasmic loop (CL4) in the C-terminal membrane-spanni

112 Four charged residues in the fifth cytoplasmic loop (CL5) connecting transmembrane helix 9

113 acts mainly between helices I and II and the cytoplasmic loop connecting helices V and VI facilitate

114 cent work on a rhodopsin mutant split in the cytoplasmic loop connecting helixes 3 and 4 has shown th

115 In the DHPR alpha(1S) subunit, the cytoplasmic loop connecting repeats II and III is a majo

116 ary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices.

117 s proteolysis prematurely, while residues in cytoplasmic loops connecting distal transmembrane segmen

118 The cytoplasmic loops connecting four homologous alpha1S str

119 rane helices (TMHs) of subunits a and c into cytoplasmic loops connecting the TMHs, suggesting these

120 idues 340 to 358) or mimetic peptide for the cytoplasmic loop (Cx40; residues 130 to 140) each marked

121 nt interaction between the Cx43CT and a Cx43 cytoplasmic loop (Cx43CL) peptide.

122 sites on helix 8 (Cys 316) and in the second cytoplasmic loop (Cys140) are greater than 12 A in phosp

123 Mutation of Val to Asp in the ORF74 second cytoplasmic loop did not affect ligand-independent signa

124 ear the N- and C-terminal parts of the third cytoplasmic loop did not result in uncoupling.

125 lation for the cytokine receptor PRLR in its cytoplasmic loop dimerization and subsequent STAT5 activ

126 treated cells, PRL receptor (PRLR) undergoes cytoplasmic loop dimerization that is acetylation-depend

127 Cytoplasmic loop-dimerized PRLR activates STAT5, which i

128 The cysteines in the M3-M4 cytoplasmic loop do not appear to be palmitoylated, but

129 dition, truncation of a large portion of the cytoplasmic loop does not alter important properties of

130 in palmitoylation of the gamma2 subunit in a cytoplasmic loop domain-dependent manner.

131 also rescued maturation of mutants in other cytoplasmic loops, either by allosteric effects or via a

132 tination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentiall

133 addition, two other amino acids in the first cytoplasmic loop exhibit epistatic suppression.

134 Cytoplasmic loop f, which plays a role in regulating the

135 model that places transmembrane segment 6 in cytoplasmic loop f.

136 in the membrane-proximal region of its third cytoplasmic loop for function, as expected for a G prote

137 We also found that the second extra-cytoplasmic loop has higher rates of evolution than the

138 The cytoplasmic loops have the highest temperature factors i

139 Periplasmic and cytoplasmic loop-helix boundaries for helices I, II, X,

140 comprised of the second (CD) and third (EF) cytoplasmic loops (HPTRX/CDEF) to bind G(t) alpha-subuni

141 0V), second transmembrane domain (L90V), and cytoplasmic loop (I130T, K134E) do form gap junction pla

142 The third cytoplasmic loop (IC3) is a determinant in the dynamic l

143 OG1 as a new protein that interacts with the cytoplasmic loop II (between transmembrane domains DII a

144 omain-swapping contacts between NBDs and MSD cytoplasmic loops in opposite halves of the protein rapi

145 Three cytoplasmic loops in the G protein-coupled receptor rhod

146 ert in D2long; both D2long and D2short third cytoplasmic loops interact with spinophilin in vitro and

147 The protein was split within the cytoplasmic loop into two domains consisting of the firs

148 a conformational change that brings several cytoplasmic loops into an arrangement optimal for intera

149 phosphorylation motif in the Na(v)1.5 DI-DII cytoplasmic loop is a critical nodal point for proarrhyt

150 The third cytoplasmic loop is a crucial site of physical contact b

151 We propose that an extended third cytoplasmic loop is adjacent to the proximal C-terminal

152 esults suggest that this region of the third cytoplasmic loop is crucial for determining G(i) protein

153 Thus, a minimum length of the central cytoplasmic loop is vital for proper insertion, stabilit

154 ne tethered cleavage reagent attached on the cytoplasmic loop IV.

155 e permease near the IIA(Glc) binding site in cytoplasmic loop IV/V and in the vicinity of the galacto

156 237 (helix VII), Asp240 (helix VII), Glu126 (cytoplasmic loop IV/V), Glu269 (helix VIII), and Glu325

157 ase mutants with polyhistidine insertions in cytoplasmic loops IV/V and VI/VII and periplasmic loop V

158 red for unphosphorylated IIA(Glc) binding to cytoplasmic loops IV/V and VI/VII.

159 Out of the 68 paired-Cys mutants in cytoplasmic loops IV/V and VIII/IX or X/XI, three pairs

160 meras in which combinations of the large hH1 cytoplasmic loops joining the four transmembrane domains

161 , present at equivalent positions within the cytoplasmic loops joining transmembrane segments 2-3 and

162 utative MAP kinase-recognition module in the cytoplasmic loop (L1), which joins domains 1 and 2.

163 ecently, a unique mutation, N(1575)Y, in the cytoplasmic loop linking domains III and IV (LIII/IV) wa

164 it (epsilonN436del) at the C-terminus of the cytoplasmic loop linking the third (M3) and fourth (M4)

165 GlyR involves the E-domain of gephyrin and a cytoplasmic loop located between transmembrane segments

166 served cysteine loop (residues 128-142), the cytoplasmic loop (M3-M4), and M4.

167 ts suggest that the C-terminal domain of the cytoplasmic loop may function in gating H(+) translocati

168 gene transfer in vivo, we show that the long cytoplasmic loop of alpha 3 targets chimeric alpha 7 sub

169 ite (IEGRIEGR) was inserted into the central cytoplasmic loop of an OxlT cysteine-less derivative in

170 xins, gamma-carboxyglutamate residues in the cytoplasmic loop of both connexins, phosphorylation in t

171 A prominent cytoplasmic loop of BtuC forms the contact region with t

172 A gain-of-function G406R mutation in a cytoplasmic loop of Ca(V)1.2 channels causes long QT syn

173 ed an interaction between the Cx40CT and the cytoplasmic loop of Cx40 as well as between the Cx40CT a

174 n (referred to as "CT") with a region in the cytoplasmic loop of Cx43 (amino acids 119 to 144; referr

175 f Cx40 as well as between the Cx40CT and the cytoplasmic loop of Cx43 (and vice versa).

176 ility, was found to associate with the third cytoplasmic loop of dopamine D(2) receptors.

177 d domain conserved specifically in the large cytoplasmic loop of gamma1-3 subunits but not in other G

178 l replacement of the amino terminus plus the cytoplasmic loop of GLUT4 in the GLUT1 backbone resulted

179 ne and it has been proposed that the central cytoplasmic loop of lactose permease is the major determ

180 ure distance from the EF-hand in the central cytoplasmic loop of lactose permease to positions 179 or

181 of M13 procoat protein fused into the middle cytoplasmic loop of LacY.

182 sease mutation, G1019D, located in the large cytoplasmic loop of MNK, was characterized in transfecte

183 The cytoplasmic loop of MotA undergoes proton-driven conform

184 esults suggest that the Ser-226 in the third cytoplasmic loop of Ntcp is phosphorylated and cAMP may

185 a1-10 (with two point mutations in the first cytoplasmic loop of Pma1), in which the newly synthesize

186 pment of an antiserum specific to the second cytoplasmic loop of PreGN allowed detection of cell-asso

187 lysine sites randomly distributed along the cytoplasmic loop of PRLR.

188 This binding is mediated by the large cytoplasmic loop of PS1 and requires the membrane-proxim

189 esponding to the N-terminal end of the large cytoplasmic loop of PS1 and the metal binding motif-cont

190 T(alpha) are in close vicinity to the third cytoplasmic loop of rhodopsin in the complex between rho

191 he third transmembrane domain and the second cytoplasmic loop of rhodopsin, is one of the most highly

192 the hexapeptide sequence MELADL located in a cytoplasmic loop of Scap.

193 ed sequence EDTEE, which is located within a cytoplasmic loop of SERINC5 and which is reminiscent of

194 The first cytoplasmic loop of subunit a of the Escherichia coli AT

195 using select loop-region Cys from the single cytoplasmic loop of subunit c and multiple cytoplasmic l

196 amino acid suppressor mutations in the first cytoplasmic loop of TatC.

197 202F replacement in the putative interdomain cytoplasmic loop of Tet(C/B).

198 of 256 amino acid residues from the central cytoplasmic loop of the alpha-subunit results in the del

199 the Arg(313)-Lys(314) sequence in the large cytoplasmic loop of the alpha-subunit to K314Q promotes

200 The major cytoplasmic loop of the alpha3 subunit targets specific

201 The third cytoplasmic loop of the angiotensin (Ang) II type 1 rece

202 dent on amino acids 221 and 222 in the third cytoplasmic loop of the AT(1).

203 hanisms of D2 receptor regulation, the third cytoplasmic loop of the D2 dopamine receptor was used to

204 3 in striatal homogenates bound to the third cytoplasmic loop of the D2 receptor, and purified arrest

205 llowing observations: 1) S100B and the third cytoplasmic loop of the dopamine D(2) receptor interact

206 alone or the GST fusion protein of the third cytoplasmic loop of the human mu opioid receptor.

207 es at the same 212 position within the third cytoplasmic loop of the human prostacyclin (hIP) recepto

208 hand motif is incorporated into the central cytoplasmic loop of the lactose permease of Escherichia

209 tion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia

210 d DRY motif expressed in the putative second cytoplasmic loop of the mu-opioid receptor were assessed

211 titution of a single threonine in the second cytoplasmic loop of the muOR (Threonine 180) blocked ago

212 The region of the cDNA that encodes the 2nd cytoplasmic loop of the protein shows a 66% identity wit

213 s modified, reveals that Thr268 in the third cytoplasmic loop of the receptor protein is primarily re

214 t serine/threonine residues within the third cytoplasmic loop of the receptor that are phosphorylated

215 a region (the 'HA-stretch') within the large cytoplasmic loop of the receptor that markedly influence

216 he dileucine motif (L314A, L315A) within the cytoplasmic loop of the receptor.

217 r domains, including those in the C-terminal cytoplasmic loop of the second membrane-spanning domain,

218 The II-III cytoplasmic loop of the skeletal muscle dihydropyridine

219 This opsin mutation is located in the second cytoplasmic loop of this G protein-coupled receptor.

220 Thus regions located outside the cytoplasmic loops of adenylyl cyclases are not only impo

221 n in primary amino acid sequences across the cytoplasmic loops of Cys-loop receptors, limiting confid

222 ation of peptides corresponding to the third cytoplasmic loops of GPCRs increases their potency as ac

223 recombinant fusion proteins composed of the cytoplasmic loops of human ACIX or the first and second

224 lection of single-Cys replacement mutants in cytoplasmic loops of lactose permease were evaluated for

225 of Ca(2+) decreases the distance between the cytoplasmic loops of NCX pairs.

226 loops of human ACIX or the first and second cytoplasmic loops of rat ACV and ACII, respectively, wer

227 Peptides corresponding to the cytoplasmic loops of rhodopsin and other control peptide

228 rall, our data support the role of the three cytoplasmic loops of rhodopsin and suggest that residues

229 sses the role of specific amino acids in the cytoplasmic loops of rhodopsin in binding arrestin throu

230 A series of alanine mutants within the three cytoplasmic loops of rhodopsin were expressed in HEK-293

231 eric receptors were constructed in which the cytoplasmic loops of rhodopsin were replaced one at a ti

232 In the resulting model, two cytoplasmic loops of SecY extend into the exit tunnel ne

233 The cytoplasmic loops of subunit a have been implicated in g

234 e cytoplasmic loop of subunit c and multiple cytoplasmic loops of subunit a, we show that Cd(+2) dire

235 set of chimeras indicate that the first two cytoplasmic loops of the cardiac sodium channel that joi

236 desensitization was determined by the M3-M4 cytoplasmic loops of the gamma- and epsilon-subunits.

237 The structures of the cytoplasmic loops of the phototaxis receptor sensory rho

238 e NF-M clone did not interact with the third cytoplasmic loops of the rat D(2), D(3), or D(4) recepto

239 indings, substitution of the amino-terminal, cytoplasmic loop, or carboxyl-terminal domains individua

240 with GLUT4 domains or the combination of the cytoplasmic loop plus the carboxyl terminus failed to di

241 (3) The cytoplasmic loops, primarily responsible for signal tran

242 per physiological function, is mediated by a cytoplasmic loop proposed to occlude the ion pore via a

243 are consistent with the idea that the middle cytoplasmic loop provides a temporal delay between inser

244 Y motif to the lipid-water interface via the cytoplasmic loops provides insight into lipid effects on

245 Two EA mutations located in the first cytoplasmic loop, R239S and F249I, yielded minimal or no

246 mplished through proper interaction with the cytoplasmic loops rather than through sequence-specific

247 ndicate that the deleted regions in the MotA cytoplasmic loop region are essential for stability; the

248 data identify an intrinsically unstructured cytoplasmic loop region connecting transmembrane helices

249 In the cytoplasmic loop region of MotA, deletions made the prot

250 ed 21 amino acid encoding exon in the II-III cytoplasmic loop region of the N-type Ca channel alpha(1

251 ur charged aspartic acid residues within the cytoplasmic loop region of the protein.

252 and the nearby charged aspartic acids of the cytoplasmic loop region to promote transmembrane alpha-h

253 cally, at the lowest frequencies probed, the cytoplasmic loop regions of the proteins are highly acti

254 ster around the cytoplasmic N-tail and first cytoplasmic loop regions of the TatC protein.

255 mely Asp36, Asp38, Asp102, and Asp104 in the cytoplasmic loop regions.

256 ral model on which the R domain is closed to cytoplasmic loops regulating channel gating.

257 e (MTSEA) with X-A342C, the construct with a cytoplasmic loop residue Cys-342 restored.

258 The third cytoplasmic loop (residues 217-273) of the rat D(1) rece

259 sequential 10-residue deletions in the ExbB cytoplasmic loop (residues 40 to 129; referred to as Del

260 d that a less accessible region of the first cytoplasmic loop (residues 75-90) is probably near the c

261 y amino acid residues within periplasmic and cytoplasmic loops, respectively.

262 on of selected conserved residues within the cytoplasmic loop results in either a partial or total lo

263 utagenesis demonstrated that a 13-amino acid cytoplasmic loop (S4-S5) determines the selective inhibi

264 the LOOP1 domain, a catalytically important cytoplasmic loop segment linking transmembrane segments

265 e T3) and at Lys-749 or Lys-754 in the M6-M7 cytoplasmic loop (site T4).

266 Point mutations in cytoplasmic loops six (L6) and eight (L8) of yeast Sec61

267 with a single amino acid substitution in the cytoplasmic loop T804M.

268 ents with incremental deletions of the third cytoplasmic loop (TH(241-348) and EF(249-348)), a fragme

269 consistent with the reported mapping of the cytoplasmic loop that contains the EDTEE sequence as a g

270 junction between the 13(th) TMH and the long cytoplasmic loop that precedes it resulted in proteins t

271 mic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central

272 The map shows density for helix 8, the cytoplasmic loops, the extracellular plug, all tryptopha

273 transmembrane domains (TMDs) connected by a cytoplasmic loop; the amino- and carboxyl-terminal tails

274 ithin the carboxyl terminus and then the 3rd cytoplasmic loop, thereby dissociating these domains and

275 ontribution of this local region of the long cytoplasmic loop to AChR assembly.

276 e residue (C621) promotes reorientation of a cytoplasmic loop to enhance nucleophilicity and modifica

277 titution of a single threonine in the second cytoplasmic loop to produce MOR(T180A) was sufficient to

278 ere constructed from the middle of the major cytoplasmic loop to the middle of the extended cytoplasm

279 ly between T and the rhodopsin mutant S240C (cytoplasmic loop V-VI).

280 bation in the membrane topology in which the cytoplasmic loop was aberrantly translocated into the ex

281 he two domains with different lengths of the cytoplasmic loop was fused to green fluorescent protein.

282 Phosphorylation of the third cytoplasmic loop was increased to a similar degree by al

283 esponsible for interacting with the D2 third cytoplasmic loop was narrowed to a region that does not

284 p7 chimera with 2a tails and TMDs and the 1a cytoplasmic loop was not viable.

285 tail, first transmembrane domain, and first cytoplasmic loop were constructed.

286 en any of the five aspartate residues in the cytoplasmic loop were converted to asparagine.

287 bstitutions of two conserved residues in the cytoplasmic loop were not viable.

288 ermease, each with a single-Cys residue in a cytoplasmic loop, were coexpressed, and cross-linking wa

289 two distinct metal-sensitive regions in the cytoplasmic loop where function was inhibited by differe

290 e carboxyl domain of the D(2) receptor third cytoplasmic loop, where there is a potential serine phos

291 the insertion of 29 amino acids in the third cytoplasmic loop, which is absent in the short isoform.

292 a high degree of steric freedom at the third cytoplasmic loop, which is increased upon C-terminus tru

293 ween membrane spans 6 and 7 there is a large cytoplasmic loop, which, along with the C-terminal tail,

294 duplicated 6- or 7-amino acid motifs within cytoplasmic loops, which are highly conserved among 50 m

295 its predicted transmembrane domains (TM) and cytoplasmic loops, which may play important structural o

296 7.8 K(d)), which contains the putative third cytoplasmic loop with three serine (Ser-213, Ser-226, an

297 structural basis for the interaction of the cytoplasmic loops with the retinal G-protein transducin

298 TMDs 1 and 2 are punctuated by a cytoplasmic loop, with the C-terminal tail also occupyin

299 Cys-135 and Cys-342, endogenous cysteines in cytoplasmic loops, with MTS reagents.

300 apping experiments identified histidine-rich cytoplasmic loops within the ZIP6/ZIP10 heteromer as a n