ライフサイエンスコーパス: cytosine deaminase

1 versification enzyme AID (activation-induced cytosine deaminase).

2 cytosine deaminase alone, or endostatin plus cytosine deaminase.

3 en annotated as a probablechlorohydrolase or cytosine deaminase.

4 that 5-FC is a poor substrate for bacterial cytosine deaminase.

5 rvival, and expression of activation-induced cytosine deaminase.

6 virus thymidine kinase and 5-fluorocytosine/cytosine deaminase.

7 rsion of pyrimidine supplements to uracil by cytosine deaminase.

8 ; and demonstrates DNA breakage via APOBEC3A cytosine deaminase.

9 ions, isoguanine is the better substrate for cytosine deaminase.

10 fied by peptide mass fingerprint analysis as cytosine deaminase.

11 actor-1-alpha antibodies, interleukin-2, and cytosine deaminase.

12 low dCK, hENT1, and 2 transporters, and high cytosine deaminase.

13 diversification by an ancestral AID-like DNA cytosine deaminase.

14 ID/APOBEC family of sequence-selective ssDNA cytosine deaminases.

15 version mechanism involving lineage-specific cytosine deaminases.

16 r VLRB assembly, together with expression of cytosine deaminase 1 (CDA1) or 2 (CDA2), respectively.

17 -6) and the bacterial metabolic suicide gene cytosine deaminase (205-IL6-CD) become highly immunogeni

18 ed the efficacy of adenoviral (Ad5)-directed cytosine deaminase/5-fluorocytosine (CD/5-FC) enzyme/pro

19 Cytosine deaminase/5-fluorocytosine (CD/5-FC) is a promi

20 thymidine kinase/ganciclovir (TK/GCV), yeast cytosine deaminase/5-fluorocytosine (yCD/5-FC) and nitro

21 Yeast cytosine deaminase, a zinc metalloenzyme, catalyzes the

22 ating that R-loops limit activation-induced (cytosine) deaminase access to the transcribed DNA strand

23 suggest that Vif binds and inhibits the non-cytosine deaminase activities of intact A3G and intact A

24 -to-AA mutations indicative of human APOBEC3 cytosine deaminase activity among Clade IIb MPXV (previo

25 enzyme catalytic polypeptide-like (APOBEC)3 cytosine deaminase activity have been found in over half

26 thereby causing elevated A3B expression and cytosine deaminase activity in cancer cells.

27 Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA edi

28 poration into virus particles and subsequent cytosine deaminase activity that attacks the nascent vir

29 o elaborate a simple method for assaying DNA cytosine deaminase activity that eliminates potential po

30 Low cytosine deaminase activity was detected when guanines f

31 Its single-stranded DNA cytosine deaminase activity, located in its C-terminal d

32 Here we show that although Apobec2a,2b lack cytosine deaminase activity, they require a conserved zi

33 uced A3B expression and concomitant cellular cytosine deaminase activity.

34 RF2 stoichiometrically inhibits APOBEC3B DNA cytosine deaminase activity.

35 ated male donor mice were incubated with the cytosine deaminase adenoviral vector and then exposed to

36 the mutagenic actions of activation induced cytosine deaminase (AICDA).

37 enes are initiated by the activation-induced cytosine deaminase AID.

38 essibility and/or recruit activation-induced cytosine deaminase (AID) and its associated processes to

39 B-cell clones manifesting activation-induced cytosine deaminase (AID) and up-regulated p53 following

40 anslocations prefer known activation-induced cytosine deaminase (AID) hotspots such as WGCW and WRC (

41 Activation-induced cytosine deaminase (AID) is a cytosine deaminase that is

42 Activation-induced cytosine deaminase (AID) is essential for both somatic h

43 Does the activation-induced cytosine deaminase (AID) that initiates SHM not gain acc

44 ed since the discovery of activation-induced cytosine deaminase (AID), the molecule responsible for t

45 gulates the expression of activation-induced cytosine deaminase (AID), which is critical for antibody

46 on (CSR) are initiated by activation-induced cytosine deaminase (AID).

47 e dependent on the enzyme activation-induced cytosine deaminase (AID).

48 imiting the expression of activation-induced cytosine deaminase (AID).

49 ymphoid tissue expressing activation-induced cytosine deaminase (AID).

50 red with the treatments of endostatin alone, cytosine deaminase alone, or endostatin plus cytosine de

51 nce identity of 29 and 25%, respectively, to cytosine deaminase and dihydroorotase, both members of a

52 Incorporating cytosine deaminase and Herpes simplex virus thymidine ki

53 The cytosine deaminase and herpes simplex virus-1 thymidine

54 The Escherichia coli gene, codA, encodes cytosine deaminase and is introduced into cancer cells f

55 osine in DNA to uracil by activation-induced cytosine deaminase and its removal by uracil-DNA glycosy

56 past decade, the connection between APOBEC3 cytosine deaminases and cancer mutagenesis has become in

57 us type 1-thymidine kinase, Escherichia coli cytosine deaminase, and human deoxycytidine kinase were

58 The cytosine deaminase APOBEC proteins have been implicated

59 Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sour

60 A likely cause is the DNA cytosine deaminase APOBEC3B (A3B).

61 example is neutralization of the nuclear DNA cytosine deaminase APOBEC3B by the Epstein-Barr virus (E

62 Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic m

63 Here we show that the DNA cytosine deaminase APOBEC3B is a probable source of thes

64 The cytosine deaminase APOBEC3B is implicated in tumor evolu

65 wide variation in the expression of the DNA cytosine deaminase APOBEC3B, with elevated expression in

66 n specifically induces the innate immune DNA cytosine deaminase APOBEC3B.

67 utational burden by expressing the human DNA cytosine deaminase, APOBEC3B, to mimic the mutational si

68 The DNA cytosine deaminase APOBEC3G (A3G) is capable of blocking

69 or by infecting with virus that contains the cytosine deaminase APOBEC3G (A3G), the proportion of rev

70 The cytosine deaminase APOBEC3G, in the absence of the human

71 as five members of the APOBEC3 family of DNA cytosine deaminases are capable of inhibiting HIV-1 repl

72 APOBEC3H and homologous single-stranded DNA cytosine deaminases are unique to mammals.

73 quences, and neomycin phosphotransferase and cytosine deaminase as positive and negative markers, res

74 The enzyme/prodrug strategy using bacterial cytosine deaminase (bCD) and 5-fluorocytosine (5-FC) is

75 We previously observed that bacterial cytosine deaminase (bCD) conjugated with multimodal imag

76 The crystal structure of bacterial cytosine deaminase (bCD) reveals that a loop structure i

77 in the substrate binding pocket of bacterial cytosine deaminase (bCD) that result in marginal improve

78 icacy of cancer gene therapy using bacterial cytosine deaminase (bCD)/5-fluorocytosine (5-FC) enzyme/

79 Activation-induced cytosine deaminase begins the process by deaminating cyt

80 talytic polypeptide-like 3 (APOBEC3; A3) DNA cytosine deaminases can be incorporated into progeny vir

81 The Apobec/AID family of cytosine deaminases can deaminate cytosine and thereby c

82 estion that remains unanswered is how AID, a cytosine deaminase, causes mutations at both G:C and A:T

83 We used the cytosine deaminase (CD) 5-fluorocytosine (5-FC) enzyme/p

84 The combination of cytosine deaminase (CD) and herpes simplex virus thymidi

85 a fusion gene comprised of Escherichia coli cytosine deaminase (CD) and herpes simplex virus type 1

86 s using AdCMV.CD, an adenovirus that encodes cytosine deaminase (CD) and is capable of metabolizing 5

87 d that requires the activity of two enzymes: cytosine deaminase (CD) and UPRT.

88 Cytosine deaminase (CD) catalyzes the deamination of cyt

89 5-fluorouracil (5-FU) by monoclonal antibody-cytosine deaminase (CD) conjugates.

90 The Escherichia coli enzyme cytosine deaminase (CD) converts the prodrug 5-fluorocyt

91 C members with two Zn-coordinated homologous cytosine deaminase (CD) domains, with the others being A

92 The enzyme cytosine deaminase (CD) encoded by codA catalyzes deamin

93 ' to the LacZ gene (Ad-Lp-LacZ) or 5' to the cytosine deaminase (CD) gene (Ad-Lp-CD) in a replication

94 Suicide gene therapy using the cytosine deaminase (CD) gene and 5-fluorocytosine (5-FC)

95 adenoviral vector (Ad.CMV.CD) containing the cytosine deaminase (CD) gene under the control of a cyto

96 of an RCR vector (ACE-CD) carrying the yeast cytosine deaminase (CD) gene, which converts the nontoxi

97 virus (CMV)-driven transcription unit of the cytosine deaminase (CD) gene.

98 Cytosine deaminase (CD) is a microbial gene undergoing c

99 Flura-seq utilizes cytosine deaminase (CD) to convert fluorocytosine to flu

100 reporter gene or the prodrug converter gene cytosine deaminase (CD) was constructed.

101 One of the most promising PGT enzymes is cytosine deaminase (CD), a microbial salvage enzyme that

102 Cytosine deaminase (CD)-based gene therapy has been show

103 g strategy is limited by the inefficiency of cytosine deaminase (CD)-catalyzed conversion of 5-FC int

104 er the bystander or protective effect of the cytosine deaminase (CD)/5-flucytosine (5-FC) gene therap

105 Adenovirus (Ad) vector-mediated cytosine deaminase (CD)/5-fluorocytosine (5-FC) gene the

106 competent, oncolytic adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine k

107 sed the fusion suicide gene Escherichia coli cytosine deaminase (CD)/uracil phosphoribosyltransferase

108 Cytosine deaminase (CDA) from Escherichia coli was shown

109 T MRI approach for detecting the activity of cytosine deaminase (CDase), an enzyme that catalyzes the

110 selection against stable integration of the cytosine deaminase (codA) gene-containing T-DNA.

111 product of ORF2 shows high similarity to the cytosine deaminase (CodA) of Escherichia coli.

112 Transcription of the cytosine deaminase (codBA) operon of Escherichia coli is

113 The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the in

114 enzymes.IMPORTANCE The APOBEC3 family of DNA cytosine deaminases constitutes a vital innate immune de

115 Cytosine deaminase converts 5-FC into cytotoxic 5-fluoro

116 While AID acts as a single-strand DNA-cytosine deaminase creating U .

117 mined the effects of intoxication by DddA, a cytosine deaminase delivered via the type VI secretion s

118 Deficiency in activation-induced cytosine deaminase diminishes but does not ablate murine

119 nase domain from APOBEC3G and the C-terminal cytosine deaminase domain from APOBEC3F elicited a dinuc

120 A chimeric protein with the N-terminal cytosine deaminase domain from APOBEC3G and the C-termin

121 Here, we show that only the C-terminal cytosine deaminase domain of APOBEC3F and -3G governs re

122 BEC3F proteins have an active N-terminal DNA cytosine deaminase domain, which elicits a broader dinuc

123 y functionalizing Cas13bt with adenosine and cytosine deaminase domains, and demonstrated packaging o

124 In lung adenocarcinoma cell lines, cytosine deaminase, driven by the CMV promoter, was supe

125 Cytosine deaminase (EC 3.5.4.1), a non-mammalian enzyme,

126 HPV-positive OSCCs, the signatures of APOBEC cytosine deaminase editing, associated with anti-viral i

127 Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, gener

128 NA editing enzyme, catalytic subunit-like 3) cytosine deaminase enzymes; however, there is no establi

129 Therefore, cytosine deaminase expressed from the CMV promotor seems

130 AID is a cytosine deaminase expressed in germinal centre B cells

131 Cytosine deaminase expression in Klebsiella pneumoniae w

132 Deletion of yeast cytosine deaminase Fcy1 significantly decreased the rate

133 that damage by the Saccharomyces cerevisiae cytosine deaminase, Fcy1, was required for both fragilit

134 Cas9 nickase variants fused to adenosine or cytosine deaminases for the simultaneous editing of spli

135 eated by amalgamating the functionalities of cytosine deaminase (from hAPOBEC3A or hAID*Delta ), aden

136 Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of

137 This endostatin-cytosine deaminase fusion approach opens an avenue for c

138 When we used the endostatin-cytosine deaminase fusion protein to treat s.c. grafted

139 ly engineered to express the E. coli-derived cytosine deaminase gene are effective in converting syst

140 Thus, only cells expressing the cytosine deaminase gene can be rescued in a positive sel

141 ther, we have developed the Escherichia coli cytosine deaminase gene codA as a conditional negative s

142 diated gene transfer of the Escherichia coli cytosine deaminase gene followed by exposure to the nont

143 e been genetically modified with a bacterial cytosine deaminase gene to express a functional enzyme.

144 AdGVCD.10 (carrying the Escherichia coli cytosine deaminase gene) was administered (8 x 10(8) to

145 tion method based upon the expression of the cytosine deaminase gene.

146 use systematic characterization of adenosine/cytosine deaminase genes has implicated the involvement

147 neumoniae differs from E. coli in having two cytosine deaminase genes, an intervening open reading fr

148 e APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunit

149 The APOBEC3 family of cytosine deaminases has been implicated in some of the m

150 The APOBEC3 family of DNA cytosine deaminases has important roles in innate immuni

151 etent adenovirus (Ad5-CD/TKrep) to deliver a cytosine deaminase/herpes simplex virus-1 thymidine kina

152 ence of AtzC was compared to that of E. coli cytosine deaminase in the regions containing the five li

153 n cancer genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a

154 ell AICD, indicating that activation-induced cytosine deaminase-induced DNA damage is only in part re

155 we reveal sites that permit splitting of DNA cytosine deaminases into two inactive fragments, whose r

156 The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cance

157 Cytosine deaminase is used in combination with 5-fluoroc

158 The APOBEC3 family of DNA cytosine deaminases is capable of restricting the replic

159 The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest

160 The DYW-family of cytosine deaminases is structurally and phylogenetically

161 rpes simplex virus thymidine kinase or yeast cytosine deaminase) is phosphorylated and stabilized in

162 The designed photocontrolled cytosine deaminases may also aid in improving chemothera

163 if are likely to bind this single-domain DNA cytosine deaminase on physically distinct surfaces.

164 We assayed 175 putative cytosine deaminases on a variety of substrates and found

165 f these proteins has elicited polynucleotide cytosine deaminase or anti-viral activity.

166 e EBV BORF2 protein relocalizes the APOBEC3B cytosine deaminase out of the nucleus, sequestering it i

167 one coherent model, and further suggest that cytosine deaminases, particularly AID, might have a broa

168 rge and highly diverse set of polynucleotide cytosine deaminase (PCD) enzymes, which is already prope

169 Activation-induced cytosine deaminase preferentially deaminates C in DNA on

170 mutational signature was due to the APOBEC3 cytosine deaminase protein family.

171 The endostatin-cytosine deaminase protein significantly inhibited the g

172 POBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against vir

173 ound to RNA, perhaps resembling APOBEC-3G, a cytosine deaminase related to AID that inhibits HIV repl

174 3G is a member of a family of polynucleotide cytosine deaminases, several of which also target distin

175 sociated with altered CpGs and APOBEC-family cytosine deaminases similar to mutation signatures deriv

176 Cytosine deaminases, such as activation-induced cytidine

177 deliver a therapeutically relevant molecule-cytosine deaminase-such that quantifiable reduction in t

178 pendent adenosine deaminase and Fe-dependent cytosine deaminase, suggesting that ACMSD may share cert

179 of herpes simplex virus thymidine kinase or cytosine deaminase suicide genes.

180 BEC3G (A3G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by

181 replicating retroviral vector (RRV) encoding cytosine deaminase that converts 5-fluorocytosine (5-FC)

182 POBEC3G (Apo3G) is a single-stranded (ss)DNA cytosine deaminase that eliminates HIV-1 infectivity by

183 APOBEC3B is a single-stranded DNA cytosine deaminase that functions normally as a nuclear-

184 vation-induced cytosine deaminase (AID) is a cytosine deaminase that is critical to immunoglobulin hy

185 -catalytic polypeptide-like 3G (APOBEC3G), a cytosine deaminase that leads to hypermutations in the v

186 Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodie

187 BEC3G or A3G) is an evolutionarily conserved cytosine deaminase that potently restricts human immunod

188 APOBEC3G belongs to a family of DNA cytosine deaminases that are involved in the restriction

189 a family of single-stranded DNA (ssDNA) DNA cytosine deaminases that are known for restriction of HI

190 G, the artiodactyl APOBEC3F proteins are DNA cytosine deaminases that locate predominantly to the cyt

191 g a potential mutational role by host APOBEC cytosine deaminases that possess broad anti-viral activi

192 APOBEC3F (A3F) and APOBEC3G (A3G) are DNA cytosine deaminases that potently restrict human immunod

193 APOBEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences

194 mentation assay based on the optimized yeast cytosine deaminase to systematically identify candidate

195 d to remove RNA allowing activation-induced (cytosine) deaminase to promote somatic hypermutation on

196 vivo using the double-stranded DNA-specific cytosine deaminase toxin DddA.

197 s tumors, our results showed that endostatin-cytosine deaminase treatment provided stronger tumor gro

198 ate both the concentration and activity of a cytosine deaminase-uracil phosphoribosyltransferase (CD-

199 highly potent prodrug activating gene [yeast cytosine deaminase/uracil phospho-ribosyltransferase fus

200 of a single bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltransferase (FCU

201 a secreted form of beta-glucuronidase and a cytosine deaminase/uracil phosphoribosyltransferase, whi

202 toxicity by secreted beta-glucuronidase and cytosine deaminase/uracil phosphoribosyltransferase.

203 e-2 (shCE2) enzyme extracellularly and yeast cytosine deaminase: uracil phosphoribosyl transferase (y

204 uding TK (TK007 and TK(SR39) mutants), yeast cytosine deaminase:uracil phosphoribosyltransferase (yCD

205 amidohydrolase protein family that includes cytosine deaminase, urease, adenine deaminase, and phosp

206 APOBEC1 cytosine deaminase was initially characterized as pairin

207 ain of APOBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an Escherichia coli

208 d to the therapeutically useful enzyme yeast cytosine deaminase, we obtained a approximately 3-fold c

209 To explore unnatural cytosine deaminases, we repurpose the adenine deaminase

210 de deformylase, threonine dehydrogenase, and cytosine deaminase, were rapidly damaged by micromolar h

211 cacy of endostatin, we fused endostatin with cytosine deaminase, which converts a prodrug 5-flucytosi

212 The bacterial codA gene encoding cytosine deaminase, which converts the non-toxic 5-fluor

213 ene is disrupted by sequences encoding yeast cytosine deaminase, which efficiently metabolizes the pr

214 is the APOBEC3 family of single-stranded DNA cytosine deaminases, which inhibits virus replication th

215 iched with a motif targeted by APOBEC family cytosine-deaminases, which strongly prefer ssDNA.

216 EC3A (A3A) is a myeloid lineage-specific DNA cytosine deaminase with a role in innate immunity to for

217 POBEC3 members, is a single-stranded (ss)DNA cytosine deaminase with antiviral activity.

218 APOBEC3A and APOBEC3G are DNA cytosine deaminases with biological functions in foreign

219 Human cells express up to 9 active DNA cytosine deaminases with functions in adaptive and innat

220 resent study, we show that the K(m) of yeast cytosine deaminase (yCD) for 5-FC was 22-fold lower when

221 the deamination reaction catalyzed by yeast cytosine deaminase (yCD), a zinc metalloenzyme of signif

222 Yeast cytosine deaminase (yCD), a zinc metalloenzyme, catalyze

223 noembryonic antigen (CEA) promoter for yeast cytosine deaminase (yCD), which converts 5-fluorocytosin

224 Yeast cytosine deaminase (yCD)-based gene therapy offers the p