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1  our understanding of the biological role of cytosine methylation.
2 ucleotides is enhanced at least eightfold by cytosine methylation.
3  is mainly independent of age divergence and cytosine methylation.
4 g that Pol V alone does not specify sites of cytosine methylation.
5 th epigenetic alterations, including genomic cytosine methylation.
6 ed to be associated with increased levels of cytosine methylation.
7 4 in somatic cells but only when there is no cytosine methylation.
8 t loss of Lsh promotes--as well as prevents--cytosine methylation.
9 iRNA production with pre-existing or de novo cytosine methylation.
10  Ligation-mediated PCR (HELP) assay to study cytosine methylation.
11 sion of AL2 or L2 causes global reduction in cytosine methylation.
12 ed TGS suppression is accompanied by reduced cytosine methylation.
13 n an appreciable drop in the level of global cytosine methylation.
14 t-generation sequencing technology to detect cytosine methylation.
15 that there are redundant pathways leading to cytosine methylation.
16 so by a complex and variable distribution of cytosine methylation.
17 ase excision repair pathway to remove excess cytosine methylation.
18 mediate epigenetic inheritance by specifying cytosine methylation.
19 ut assays, including the HELP assay to study cytosine methylation.
20  efficient only in contexts known to feature cytosine methylation.
21 e rate-limiting product release steps during cytosine methylation.
22 ate and exhibit a 60-80% decrease in genomic cytosine methylation.
23 ic profiling and intergenomic comparisons of cytosine methylation.
24 ding developmental abnormalities and reduced cytosine methylation.
25  exhibited a 60% reduction of global genomic cytosine methylation.
26 3D genome organization, gene expression, and cytosine methylation.
27                                  We measured cytosine methylation (5-mC) content in genomic DNA from
28                                              Cytosine methylation (5-methylcytosine [5mC]) of DNA is
29 e approaches, we propose the hypothesis that cytosine methylation (5mC) and histone methylation H3K36
30 bout the predominant cytosine modifications, cytosine methylation (5mC) and hydroxymethylation (5hmC)
31    We examined two forms of DNA methylation, cytosine methylation (5mC) and hydroxymethylation (5hmC)
32                                  In mammals, cytosine methylation (5mC) is widely distributed through
33 chromatin found in higher eukaryotes, namely cytosine methylation (5mC), methylation of histone H3 ly
34 enetic modifications, such as H3K9me3 and C5 cytosine methylation (5mC).
35                                              Cytosine methylation, a common form of DNA modification
36               Mammalian development requires cytosine methylation, a heritable epigenetic mark of cel
37 ing domain proteins mirrors the detection of cytosine methylation abundance and implicates the presen
38              The use of enzymes sensitive to cytosine methylation allows high-throughput analysis of
39        The data herein provide evidence that cytosine methylation, although occurring at a low level,
40                  Bisulfite sequencing allows cytosine methylation, an important epigenetic marker, to
41 mplete pipeline for accurate CpG and non-CpG cytosine methylation analysis at single base-resolution
42 d reproducible results as exemplified by the cytosine methylation analysis of the promoter regions of
43 logic studies that can measure site-specific cytosine methylation and adduct formation will improve o
44 arise from BPDE damage and are influenced by cytosine methylation and BPDE stereochemical considerati
45  spacer (IGS) structure, they showed altered cytosine methylation and chromatin condensation patterns
46 gene expression in CD4+ T cells, we compared cytosine methylation and chromatin structure at the IL-2
47           This is accepted as resulting from cytosine methylation and deamination of 5-methylcytosine
48 indings suggest that loss of balance between cytosine methylation and demethylation during the circad
49 inactivation, the functional significance of cytosine methylation and demethylation in mouse embryoge
50                                              Cytosine methylation and demethylation in tracks of CpG
51               Integrated network analysis of cytosine methylation and expression datasets has the pot
52 mal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, c
53 ombination led to increased levels of global cytosine methylation and formylation, reduced cytosine h
54                                  Genome-wide cytosine methylation and gene expression profiling showe
55 ysregulated loci with quantitative assays of cytosine methylation and gene expression.
56 xhibited dramatic reductions of both genomic cytosine methylation and genome-wide H3K9 trimethyl leve
57 have identified Cxxc1 as a regulator of both cytosine methylation and histone 3 lysine 4 trimethylati
58 nger protein 1 (Cfp1) is a regulator of both cytosine methylation and histone methylation.
59             Epigenetic modifications such as cytosine methylation and histone modification are linked
60 s, especially small RNAs that can direct the cytosine methylation and histone modifications that are
61 h proteins are required for normal levels of cytosine methylation and hydroxymethylation in murine em
62 smoke significantly affected the patterns of cytosine methylation and hydroxymethylation in the lungs
63 urthermore, base pair resolution analysis of cytosine methylation and hydroxymethylation with oxidati
64 human brain, including the regulation of DNA cytosine methylation and hydroxymethylation, and a subse
65  transgenic plants led to a reduced level of cytosine methylation and increased expression of a targe
66  the demethylase TET enzyme led to decreased cytosine methylation and increased hydroxymethylation du
67                              However, beyond cytosine methylation and its oxidated derivatives, very
68  been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine
69                                          DNA cytosine methylation and methyl-cytosine binding domain
70 all interfering RNAs (24 nt siRNA) guide the cytosine methylation and silencing of transposons and a
71 egion (NOR) decondensation, loss of promoter cytosine methylation, and replacement of histone H3 Lys
72 ex interplay among nuclear receptor ligands, cytosine methylation, and the metabolome in both the ind
73                        Stochastic changes in cytosine methylation are a source of heritable epigeneti
74 methylome; and (3) TDCIPP-induced impacts on cytosine methylation are localized to CpG islands within
75      The extent and biological impact of RNA cytosine methylation are poorly understood, in part owin
76                              Patterns of DNA cytosine methylation are subject to mitotic inheritance
77 ion assay revealed that M. graminicola lacks cytosine methylation, as expected if its MgDNMT gene is
78 used a novel and highly sensitive genomewide cytosine methylation assay to detect and map genome meth
79 que that can be used to assess the levels of cytosine methylation associated with repetitive DNA sequ
80 ical- and chromosome-specific alterations in cytosine methylation at 2 hpf.
81                                 IUGR changes cytosine methylation at approximately 1,400 loci (false
82 rfering RNAs (siRNAs) are less abundant, and cytosine methylation at both transgenic and endogenous R
83                  In these mutants, symmetric cytosine methylation at CG and CHG motifs is reduced, an
84 SE 1 (MET1) controls faithful maintenance of cytosine methylation at CG sites in repetitive regions a
85                                              Cytosine methylation at CpG dinucleotides is a critical
86                                              Cytosine methylation at CpG dinucleotides produces m(5)C
87 iana, small interfering RNAs (siRNAs) direct cytosine methylation at endogenous DNA repeats in a path
88 ted cytosine and a corresponding increase in cytosine methylation at key regulatory regions on the vi
89 ing ATPase DDM1 is specifically required for cytosine methylation at linker histone H1-associated het
90  evidence that Lsh also controls genome-wide cytosine methylation at nonrepeat sequences and relate t
91                         CTCF is sensitive to cytosine methylation at position 2, but insensitive at p
92                   Despite widespread loss of cytosine methylation at regulatory sequences, including
93 pigenomic state by revealing its genome-wide cytosine methylation at single base resolution.
94             The oligomers exhibited 5-carbon cytosine methylation at the codon 273 location on the bo
95                                  Analysis of cytosine methylation at the endogenous MEA-ISR, AtREP2 a
96 rked, stable histone acetylation and loss of cytosine methylation at the IL-2 promoter/enhancer.
97 B1 induction in HepG2 cells is ascribable to cytosine methylation at the promoter, which prevents rec
98 s, and this enhancement of binding is due to cytosine methylation at these sequences.
99 e may perturb the methyltransferase-mediated cytosine methylation at this site, thereby interfering w
100                    Here we briefly introduce cytosine methylation before reviewing what is currently
101 ty and cytosine methylation, consistent with cytosine methylation being guided by base-pairing of Pol
102 nomic comparison found marked differences in cytosine methylation between spermatogenic and brain cel
103 ntified in the composition and patterning of cytosine methylation between the two genomes.
104  undergo epigenetic modifications, including cytosine methylation by DNA methyltransferases (DNMTs).
105 s 1258 SUMMARY: Heritable gains or losses of cytosine methylation can arise stochastically in plant g
106                                  We identify cytosine methylation changes associated with kidney stru
107 0) found that genetic changes were rare, and cytosine methylation changes were frequent.
108                                              Cytosine-methylation changes are stable and thought to b
109  the loss of H3K4me3 and then subsequent DNA cytosine methylation, changes that were heritable across
110 24-nucleotide (nt) siRNA complementarity and cytosine methylation, consistent with cytosine methylati
111 ts have found that epigenetics, particularly cytosine methylation, could play a role in the etiologic
112                     Microarray analysis in a cytosine methylation-deficient mutant of E. coli shows i
113 erous modest ( approximately 20%) changes in cytosine methylation depending on paternal diet, includi
114     These mutations had differing effects on cytosine methylation depending on the element and the se
115 entous fungus Neurospora crassa is marked by cytosine methylation directed by trimethylated Lysine 9
116                                              Cytosine methylation does not reinforce or replace ances
117 replicating nuclei and determine genome-wide cytosine methylation dynamics during the plant cell cycl
118 it a decreased plating efficiency, decreased cytosine methylation, elevated global levels of histone
119  IV helps produce siRNAs that target de novo cytosine methylation events required for facultative het
120 r this developmental pattern of low juvenile cytosine methylation followed by higher methylation in a
121      Here, we present the genome-wide map of cytosine methylation for two maize inbred lines, B73 and
122 ic reprograming event involving depletion of cytosine methylation from DNA and histone H3 lysine 9 di
123  mtDNMT1 appears to be responsible for mtDNA cytosine methylation, from which 5hmC is presumed to be
124 tent stem cells the genomic distributions of cytosine methylation, H2A.Z, H3K4me1/2/3, H3K9me3, H3K27
125                   Our findings indicate that cytosine methylation has a broader mutational footprint
126       A reduction in the DNA modification of cytosine methylation has been linked directly to chromos
127                                              Cytosine methylation has been shown to regulate essentia
128                                     Although cytosine methylation has key roles in several processes
129                          The distribution of cytosine methylation in 6.2 Mb of the mouse genome was t
130 ound that binding of p53 was not affected by cytosine methylation in a majority of cases.
131        Here, we describe that HELLS controls cytosine methylation in a nuclear compartment that is in
132 port high coverage methylomes that catalogue cytosine methylation in all contexts for the major human
133 subtype- and disease-specific alterations in cytosine methylation in ALL that influence transcription
134 st three pathways control maintenance of DNA cytosine methylation in Arabidopsis thaliana.
135 yze patterns of histone modification and DNA cytosine methylation in cancer and matched normal mucosa
136 ocytes, implicating Dnmt3b in maintenance of cytosine methylation in cancer.
137     Deletion of Lsh alters the allocation of cytosine methylation in chromosomal regions of 50 kb to
138 me but argue against a direct role for sperm cytosine methylation in dietary reprogramming of offspri
139  identified, and that transcription-targeted cytosine methylation in gene bodies contributes to the p
140  these data, we highlight predicted roles of cytosine methylation in global cellular metabolism provi
141 ptible to RIP, resulting in complete loss of cytosine methylation in M. graminicola.
142 erging from these studies is that removal of cytosine methylation in mammalian cells can occur by DNA
143  5' end of genes and normally protected from cytosine methylation in mammals.
144 dingly, the Bdnf promoter exhibited aberrant cytosine methylation in mutant Htt-expressing cortical n
145                               Maintenance of cytosine methylation in plants is controlled by three DN
146 des in two specific contexts consistent with cytosine methylation in S. cerevisiae.
147  of the SUNN promoter revealed low levels of cytosine methylation in the 700-bp region proximal to th
148  presents the first comprehensive picture of cytosine methylation in the epitranscriptome of pluripot
149                                              Cytosine methylation in the genome of Drosophila melanog
150  is a nuclear protein that binds to sites of cytosine methylation in the genome.
151  into the distribution and dynamic nature of cytosine methylation in the genome.
152 dence linking arsenic exposure with aberrant cytosine methylation in the global genome or at specific
153 ppressed histone H3 acetylation and enhanced cytosine methylation in the Nlgn1 promoter region and de
154        E(3) was identical to E(2) but showed cytosine methylation in the promoter region and was thus
155 and repeated injections with LY379268 reduce cytosine methylation in the promoters of the three genes
156          Here we show the first evidence for cytosine methylation in the S. mansoni genome.
157                                  The role of cytosine methylation in the structure and function of en
158 ation timing and DNase hypersensitivity with cytosine methylation in two human cell types, unexpected
159                  The biological functions of cytosine methylation include host defense, genome stabil
160 t overlap sites of 24-nt siRNA biogenesis or cytosine methylation, indicating that Pol V alone does n
161                             Treatment with a cytosine methylation inhibitor completely suppressed the
162                              Design of novel cytosine methylation inhibitors would be advanced by our
163                                          DNA cytosine methylation is a central epigenetic marker that
164                                          DNA cytosine methylation is a central epigenetic modificatio
165                                              Cytosine methylation is a key epigenetic mark in many or
166                                              Cytosine methylation is a key mechanism of epigenetic re
167                                    Thus, DNA cytosine methylation is a regulator of stationary phase
168                                              Cytosine methylation is a ubiquitous modification in mam
169                                RNA-dependent cytosine methylation is also reduced, but only ~20%, sug
170                                              Cytosine methylation is an ancient process with conserve
171                                              Cytosine methylation is an epigenetic and regulatory mar
172                                              Cytosine methylation is an epigenetic mark that dictates
173                                              Cytosine methylation is an epigenetic mark that plays an
174                                              Cytosine methylation is an epigenetic mechanism in eukar
175                                          DNA cytosine methylation is an epigenetic modification invol
176                                              Cytosine methylation is an important base modification t
177                                          DNA cytosine methylation is an important epigenetic regulato
178                 An inevitable consequence of cytosine methylation is an increase in C-to-T transition
179                                              Cytosine methylation is critical in mammalian developmen
180                                          DNA cytosine methylation is crucial for retrotransposon sile
181 by both methyltransferases and the effect on cytosine methylation is dependent on the position of 6-t
182 es and transposable elements, DNMT1-mediated cytosine methylation is essential for kidney development
183    Understanding cell-to-cell variability in cytosine methylation is essential for understanding cell
184                                              Cytosine methylation is found in the genomes of many pla
185                                              Cytosine methylation is important for transposon silenci
186                                              Cytosine methylation is involved in various biological p
187                                              Cytosine methylation is mediated by a group of proteins
188 hanges post-LPS stimulation, suggesting that cytosine methylation is one of the dominant mechanisms d
189                                          DNA cytosine methylation is one of the major epigenetic gene
190                                  In mammals, cytosine methylation is predominantly restricted to CpG
191 y removes thymine from DNA contexts in which cytosine methylation is prevalent, including CG and one
192  the remaining majority of the genome, where cytosine methylation is targeted preferentially to the t
193                                              Cytosine methylation is the major covalent modification
194                                              Cytosine methylation is the most common covalent modific
195 ggestion is compatible with the finding that cytosine methylation is universal among large-genome euk
196                                              Cytosine methylation is widespread in most eukaryotic ge
197           Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated
198 ough a cyclic enzymatic cascade comprised of cytosine methylation, iterative oxidation of methyl grou
199 3 are methylated in infected plants and that cytosine methylation levels are significantly reduced in
200                                              Cytosine methylation levels showed a gradual decrease wi
201 an result in changes to both 24 nt siRNA and cytosine methylation ((m)C) levels in the hybrid.
202 odification in any worm species and link the cytosine methylation machinery to platyhelminth oviposit
203            Here, we report a high-resolution cytosine methylation map of the murine genome modulated
204 eraction with SCN, we generated whole-genome cytosine methylation maps at single-nucleotide resolutio
205 lysine 9, lysine 27 (H3K9me3, H3K27me3), and cytosine methylation (mC), in the normal and cancer geno
206 MS/MS method, the impact of 6-thioguanine on cytosine methylation mediated by two DNA methyltransfera
207                                              Cytosine methylation might be partially responsible, but
208                                      Non-CpG cytosine methylation occurs in human somatic tissue, is
209                                              Cytosine methylation of a relevant promoter of the GR ge
210  describe, for the first time, the extent of cytosine methylation of bacterial DNA at single-base res
211 tion of siRNAs that, in turn, direct de novo cytosine methylation of corresponding gene sequences.
212 s transcription, and studies have shown that cytosine methylation of CpG islands in promoter regions
213                       This includes covalent cytosine methylation of DNA and its associated oxidation
214                        These changes include cytosine methylation of DNA at cytosine-phosphate dieste
215                                              Cytosine methylation of DNA CpG dinucleotides in gene pr
216                                              Cytosine methylation of DNA is a widespread modification
217                                              Cytosine methylation of DNA is an epigenetic modificatio
218             Chromatin modifications, such as cytosine methylation of DNA, play a significant role in
219 hereby small interfering RNAs (siRNAs) guide cytosine methylation of homologous DNA sequences.
220                             Here we examined cytosine methylation of human kidney tubules using Illum
221 y various mechanisms, including high-density cytosine methylation of L1 promoters and DICER-dependent
222  DNA methyltransferase 3A (DNMT3A) catalyzes cytosine methylation of mammalian genomic DNA.
223                                              Cytosine methylation of regulatory regions, such as prom
224                  We recently identified that cytosine methylation of the SULF2 promoter is associated
225                           We have correlated cytosine methylation of two epialleles, P1-rr and P1-pr,
226 rs resistance to geminiviruses by increasing cytosine methylation of viral genomes, suggestive of enh
227 d methods, allows one to sensitively measure cytosine methylation on a genome-wide scale within speci
228                                              Cytosine methylation on CpG dinucleotides is an essentia
229  approach was used to analyze the effects of cytosine methylation on the kinetics of AGT repair of O(
230 uence of DNA sequence context and endogenous cytosine methylation on the kinetics of AGT-dependent re
231                  The influence of epigenetic cytosine methylation on the reaction with anti-BPDE at a
232 r physical characteristics and the impact of cytosine methylation on these properties.
233                           Inheritance of DNA cytosine methylation pattern during successive cell divi
234 ined molecules with nearly every conceivable cytosine-methylation pattern at each locus.
235  Human DNMT3A is responsible for de novo DNA cytosine methylation patterning during development.
236                   Widespread perturbation of cytosine methylation patterning now appears to be a hall
237                               Alterations in cytosine methylation patterns are usually observed in hu
238                                We found that cytosine methylation patterns at Pl-Blotched were indeed
239                          The heritability of cytosine methylation patterns from parent to progeny cel
240                         Here, we interrogate cytosine methylation patterns in sperm obtained from mic
241                  The consequences of altered cytosine methylation patterns include both inappropriate
242  further observed that specific sequence and cytosine methylation patterns surrounding the targeted g
243 nd noncoding repeats, siRNAs specify de novo cytosine methylation patterns that are recognized by MBD
244  DNA damage could cause heritable changes in cytosine methylation patterns, resulting in human tumor
245 ealed an unappreciated complexity of genomic cytosine-methylation patterns in both tissue derived and
246 e major groove of methylated DNA rather than cytosine methylation per se.
247 lly contradict previous observations of high cytosine methylation polymorphism within Arabidopsis tha
248                                       Single cytosine methylation polymorphisms are not linked to gen
249 -PCR (nanoHELP) assay to compare genome-wide cytosine methylation profiles between highly purified hu
250         These results show that quantitative cytosine methylation profiling can be used to identify m
251 nalysis technology to complete a large-scale cytosine methylation profiling study involving 47 gene p
252 rations and gene expression, and genome-wide cytosine methylation profiling using the HpaII tiny frag
253                                              Cytosine methylation promotes deamination.
254 developed, and, together with results from a cytosine methylation protection assay, we determined the
255                                              Cytosine methylation provides an attractive epigenetic m
256                   We use our method to infer cytosine methylation rates at several sites within the p
257                                              Cytosine methylation regulates essential genome function
258                                          DNA cytosine methylation regulates gene expression in mammal
259                                              Cytosine methylation regulates the length and stability
260 ionine (SAMe), the principal methyl donor in cytosine methylation, regulates the methylome dynamics d
261 d proportion of the neuronal genome is under cytosine methylation regulation and provide a new founda
262 ver, their recently described sensitivity to cytosine methylation represents a major bottleneck for g
263                                   Eukaryotic cytosine methylation represses transcription but also oc
264                                              Cytosine methylation silences transposable elements in p
265 methyltransferase-DNA (MTase-DNA) adducts at cytosine methylation sites.
266 he Arabidopsis SAH1 gene that causes loss of cytosine methylation specifically in non-CG contexts con
267 ndicate that the inheritance of differential cytosine methylation states at NOR loci can be modified
268 uencing (WGBS) make it possible to determine cytosine methylation states at single-base resolution ac
269           Nonetheless, regional variation of cytosine methylation states was widespread in the tetrap
270 r that independently established the correct cytosine methylation status at the target CG of each mol
271 pproaches have been developed to interrogate cytosine methylation status genome-wide, however these a
272 quely, MethylViewer can simultaneously query cytosine methylation status in bisulfite-converted seque
273                    Accurate determination of cytosine methylation status in promoter CpG dinucleotide
274  activity can be manipulated by altering its cytosine methylation status in vitro.
275 lated mutations and epimutations (changes in cytosine methylation status) in mutation accumulation (M
276 thylation analysis and rapid quantitation of Cytosine methylation suitable for a wide range of biolog
277 nerated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpres
278  that is critical for normal distribution of cytosine methylation throughout the murine genome.
279 sures post-replication temporal evolution of cytosine methylation, thus enabling genome-wide monitori
280 small interfering RNAs (siRNAs), which guide cytosine methylation to corresponding sequences, require
281            Epigenetic modification of DNA by cytosine methylation to produce 5-methylcytosine (5mC) h
282                             Genome losses in cytosine methylation upon SmDnmt2 silencing and the iden
283  Summary We conducted genome-wide mapping of cytosine methylation using methylcytosine immunoprecipit
284 matin marks (H3K4me3, H3K36me2, H3K27me3 and cytosine methylation) using publicly available data.
285 hite, allowing genome-wide quantification of cytosine methylation via high-throughput sequencing.
286 ethyltransferase enzymes (DCMTases) catalyze cytosine methylation via reaction intermediates in which
287                                        While cytosine methylation was assayed in various regions span
288                                              Cytosine methylation was measured in blood using pyroseq
289                                 Variation in cytosine methylation was particularly dramatic over tand
290 ns were similar among all lines studied, but cytosine methylation was slightly more prevalent in the
291               The catalytic mechanism of DNA cytosine methylation was studied by structurally and fun
292 hailandensis, revealed that, upon induction, cytosine methylation was targeted specifically to the ph
293 pus, exhibited rapid and dramatic changes in cytosine methylation when DNMT activity was inhibited.
294 t commonly studied epigenetic alterations is cytosine methylation, which is a well recognized mechani
295 rimary effect of aza-C is the prohibition of cytosine methylation, which results in covalent methyltr
296         We conclude that the relationship of cytosine methylation with heterochromatin is not simple
297 ined epigenetic heterogeneity as assessed by cytosine methylation within defined genomic loci with fo
298                                 In contrast, cytosine methylation within p53 codon 158 slightly incre
299                                              Cytosine methylation within RNA is common, but its full
300                                              Cytosine methylation within the gene encoding for FK506

 
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