ライフサイエンスコーパス: cytosolic

1 is a protein essential for the maturation of cytosolic [4Fe-4S] proteins.

2 Activating mutations in cytosolic 5'-nucleotidase II (NT5C2) are considered to d

3 state, and previous characterizations of the cytosolic AAA+ domain in vitro had proved challenging du

4 A cytosolic accumulation of metal ions can lead to mismeta

5 genetic engineering of promastigotes for cytosolic accumulation of UV-sensitive uroporphyrin (URO

6 ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental

7 atic Acox1 deficiency markedly lowered total cytosolic acetyl-CoA levels, which led to decreased Rapt

8 per se can influence protein homeostasis of cytosolic aggregation-prone proteins.

9 howed that TubZIP28 bound to the promoter of cytosolic AGPase and enhanced both the transcription and

10 astic 2Fe-2S biogenesis pathway to different cytosolic and chloroplastic Fe-S proteins, as well as to

11 e Der1 protein form two "half-channels" with cytosolic and luminal cavities, respectively, and latera

12 cilitate movement of transmembrane segments, cytosolic and luminal funnels in TMCO1 and TMEM147, resp

13 The loss of HIPK2 increases cytosolic and mitochondrial Parkin protein levels under

14 XS17 is likely involved in the maturation of cytosolic and nuclear Fe-S proteins.

15 equired for biogenesis of numerous essential cytosolic and nuclear Fe/S proteins, explaining the esse

16 ional single-cell immunoblots to detect both cytosolic and nuclear proteins.

17 Therefore, to better study K-PPn of cytosolic and nuclear targets, we constructed a yeast st

18 is asymmetric, with one open and one closed cytosolic and periplasmic portal.

19 B provides a control function that regulates cytosolic and SR Ca(2+) levels.

20 at human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous

21 ed with a redistribution of dopamine between cytosolic and vesicular pools, leading to increased accu

22 organization of AIS intracellular membrane, cytosolic, and microtubule compartments.

23 matic mono-glycosylation of various nuclear, cytosolic, and mitochondrial proteins on serine/threonin

24 ensor, ClopHensor, reporting the dynamics of cytosolic anion concentration and pH to monitor the acti

25 Redox signaling could be impaired by cytosolic antioxidants; hence, those targeting mitochond

26 tion in mitochondria boosts the synthesis of cytosolic aspartate (Asp) and NAA, which is impeded by a

27 increases in noradrenaline release and large cytosolic astrocytic Ca(2+) elevations, cAMP changes wer

28 The cytosolic ATPase Cdc48 drives extraction by pulling on p

29 at the innate immune response to an obligate cytosolic bacterial pathogen lies at the intersection of

30 , a protein aggregate, a mitochondrion, or a cytosolic bacterium.

31 Tpx depletion abolishes the cytosolic, but only partially affects the mitochondrial

32 specific focus on the mechanism by which the cytosolic C terminus of the synaptic cell adhesion prote

33 mor-expressed CA isozyme IX (CA IX), and the cytosolic CA I, CA II, and membrane-bound CA IV.

34 f TRPC4, which is not mimicked by increasing cytosolic Ca(2+) .

35 identify POSH as a crucial link that bridges cytosolic Ca(2+) alteration with JNK activation and Hipp

36 nternal stores that play a major role in the cytosolic Ca(2+) concentration rise upon cell activation

37 e amplitude, duration, and duty cycle of the cytosolic Ca(2+) contraction signal and spatial localiza

38 These findings suggest increased cytosolic Ca(2+) duty cycle as a plausible mechanism for

39 Our simulations reveal that diastolic cytosolic Ca(2+) elevation as a result of rapid pacing t

40 ressing moss PpGLR1, ACC induces the highest cytosolic Ca(2+) elevation compared to all twenty protei

41 ptides requires long-lasting, high levels of cytosolic Ca(2+) However, the molecular regulation of ne

42 or SSM5, we used a functional assay based on cytosolic Ca(2+) imaging.

43 al role of GLR3.3 in the amino acid-elicited cytosolic Ca(2+) increase in Arabidopsis seedling roots.

44 es in the form of SWPs and the generation of cytosolic Ca(2+) increases to propagate systemic wound s

45 nt effect on store-operated Ca(2+) entry, on cytosolic Ca(2+) oscillations generated by receptor stim

46 itates Ca(2+) balance in response to dynamic cytosolic Ca(2+) perturbations is unknown.

47 Cytosolic Ca(2+) regulates multiple steps in the host-ce

48 Current models assume that cytosolic Ca(2+) regulates workload and that mitochondri

49 Acidic pH(i) (6.75-6.25) together with the cytosolic Ca(2+) rise accelerated G(i/o) -mediated TRPC4

50 ated Ca(2+) liberation posits that cell-wide cytosolic Ca(2+) signals arise through coordinated activ

51 nder widely, interact with APCs, and exhibit cytosolic Ca(2+) transients and elevated basal Ca(2+) le

52 We hypothesized that cytosolic Ca(2+), but not mitochondrial matrix Ca(2+), m

53 s induced rapid spatiotemporally overlapping cytosolic Ca(2+), H(+), and anion dynamics, but except f

54 ) release, which, in turn, reduces diastolic cytosolic Ca(2+), leading to alternations in diastolic c

55 Ca(2+), leading to alternations in diastolic cytosolic Ca(2+), RyR2 inactivation, and sarcoplasmic re

56 via the mitochondrial Rho GTPase MIRO-1 and cytosolic Ca(2+).

57 llular vesicles (EVs) lead to an increase in cytosolic Ca(2+).

58 hether corresponding dark-induced changes in cytosolic [Ca(2+) ] ([Ca(2+) ](cyt) ) can be detected.

59 suggested inhibitory effects of even resting cytosolic [Ca(2+)] on I(Na).

60 IM1 activated SOCE and generated spontaneous cytosolic Ca2+ flows.

61 pressure changes in the pancreas can elevate cytosolic calcium (Ca2+) levels, it is not known how tra

62 Mechanisms that control mobilization of cytosolic calcium [Ca(2+)](i) are key for regulation of

63 studies showing simultaneous measurement of cytosolic calcium and protein kinase A activity are show

64 peed measurements of cell length changes and cytosolic calcium concentration using confocal line scan

65 method for measuring contractile forces and cytosolic calcium dynamics of single muscle fibers.

66 ion of the signalling network underlying the cytosolic calcium fluctuations are hitherto not fully un

67 hat compound A analogs decreased GLT-induced cytosolic calcium influx in islet cells, and all measure

68 Our results suggest that taming cytosolic calcium overload in pancreatic islets can impr

69 The sequential rise and fall of cytosolic calcium underlies the contraction-relaxation c

70 high-affinity rhodamine-dextran or chelating cytosolic calcium with BAPTA-AM attenuated Tat endolysos

71 The calcium chelator BAPTA-AM, which reduces cytosolic calcium, rescues the defective ATP2C1 KO pheno

72 ular calcium and is accompanied by increased cytosolic calcium.

73 metabolon hypothesis, direct association of cytosolic carbonic anhydrases (CAs) with the electrogeni

74 moving next to a curvilinear track, e.g., a cytosolic cargo transported by motor proteins moving alo

75 n of an autophagosome selectively around the cytosolic cargo, that is, a protein aggregate, a mitocho

76 resses published discrepancies as to whether cytosolic CAs stimulate NBCe1-A, heterologously expresse

77 Cytosolic caspase-8 is a mediator of death receptor sign

78 y cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin fragments and then activating the st

79 The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to generate acetyl-CoA, and is upregul

80 After ATP depletion, we observed significant cytosolic compaction and extensive cytoplasmic reorganiz

81 cGAS was initially located in the cytosolic compartment of pDCs and time-dependently coloc

82 king and increased PDE10A degradation in the cytosolic compartment.

83 e previously reported Hsc70-Hsp105-SGTA-Bag2 cytosolic complex that also mediates SV40 ER-to-cytosol

84 The antitoxin, DarG(Mtb) , forms a cytosolic complex with DNA-repair proteins that assemble

85 r basis for selective degradation of sizable cytosolic components.

86 The ratio between the cytosolic concentrations of lactate and pyruvate is a di

87 evelopmental zones of the root revealed that cytosolic concentrations varied between developmental zo

88 organelle lumen but also, actively modifying cytosolic conditions.

89 stion remains whether the lateral portals or cytosolic constriction conduct ions upon channel opening

90 lective autophagy is the capture of specific cytosolic contents in double-membrane vesicles that subs

91 ly induces 4-1BB and cRel to enable elevated cytosolic cRel:IkappaBalpha complex formation and subseq

92 Deletion of histone deactelyase 6 (HDAC6), a cytosolic deacetylase that regulates tubulin acetylation

93 n at Ser(166) Consequently, formation of the cytosolic death-inducing complex II and subsequent RIPK1

94 RIM21 uses anti-N antibodies to target N for cytosolic degradation and generate cytotoxic T cells (CT

95 The polymers were screened for cytosolic delivery efficiency using imaging flow cytomet

96 ination of peptides that address barriers to cytosolic delivery individually and in tandem.

97 According to the resulting HC-CAPA, cytosolic delivery of CPS equipped with four benzopolysu

98 efficiency using imaging flow cytometry with cytosolic delivery validated using confocal microscopy a

99 standards of the quantitative evaluation of cytosolic delivery, the recent chloroalkane penetration

100 ltransferase 1 (HAT1) is responsible for the cytosolic diacetylation of newly synthesized histone H4

101 ng animals to normoxic conditions results in cytosolic dispersion of PFK-1.1.

102 Cytosolic DNA acts as a universal danger-associated mole

103 Recent evidence has indicated that cytosolic DNA and abnormal activation of the cytosolic D

104 nterferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses aga

105 Our findings indicate that the presence of cytosolic DNA and subsequent activation of cytosolic DNA

106 The presence of cytosolic DNA in aortic cells and activation of the STIN

107 enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and malignant cells and cataly

108 dic AAD tissues, we observed the presence of cytosolic DNA in SMCs and macrophages and significant ac

109 When cytosolic DNA is sensed, a signal is relayed via the cGA

110 cytosolic DNA and abnormal activation of the cytosolic DNA sensing adaptor STING (stimulator of inter

111 f cytosolic DNA and subsequent activation of cytosolic DNA sensing adaptor STING signaling represent

112 dendritic cells (DCs) and activates the host cytosolic DNA sensing STING/interferon I pathway, result

113 berculosis is an activator of cGAS-dependent cytosolic DNA sensing, we set out to investigate a role

114 Here, we demonstrated that the cytosolic DNA sensor cGAS recognizes baculoviral DNA and

115 Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor that elicits robust innate immune r

116 AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular sene

117 Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune res

118 ndrial DNA (mtDNA) release and activation of cytosolic DNA-mediated inflammatory response in neurons.

119 g the stimulator of interferon genes (STING) cytosolic DNA-sensing pathway and downstream interferon

120 HsZnT8; and two adjacent sites buried in the cytosolic domain and chelated by conserved residues from

121 Our results suggest that EMC's cytosolic domain contains a large, moderately hydrophobi

122 tween the second transmembrane helix and the cytosolic domain.

123 hese mutations act on the transmembrane (TM) cytosolic domain.

124 Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation

125 replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a

126 riggers host innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic

127 Following the detection of cytosolic double-stranded DNA from viral or bacterial in

128 rse multiple barriers in sequence to achieve cytosolic drug delivery.

129 s a second messenger produced in response to cytosolic dsDNA that activates the stimulator of interfe

130 mely difficult because the GFP signal of the cytosolic echoform will almost inevitably mask that of t

131 like proteins (CBLs) can sense and translate cytosolic elevation of the second messenger Ca(2+) into

132 the lateral windows, and L402C/L403C, at the cytosolic ends of the MA-helices, are conducive for disu

133 of the metal-binding site to the external or cytosolic environment.

134 As the cytosolic enzyme aldehyde dehydrogenase 1A3 turns out to

135 stone deacetylase 6 (HDAC6) is a multidomain cytosolic enzyme having tubulin deacetylase activity tha

136 the mitochondrial matrix (exon 1a) or remain cytosolic (exon 1b).

137 and immunoblot) while decreasing the nuclear/cytosolic expression ratio for HDAC4 (histone deacetylas

138 d these gating checkpoints in the middle and cytosolic extended TM domain regions.

139 oid cell-specific deletion of the neutrophil cytosolic factor 1 (Ncf1)/p47(phox) gene, which encodes

140 (HOPS) complex, was recently identified as a cytosolic factor involved in the formation of neuroendoc

141 anti-N immune protection is mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

142 rst structure of the FdsBG subcomplex of the cytosolic FdsABG formate dehydrogenase from the hydrogen

143 Fe-2S clusters to DRE2, a key protein of the cytosolic Fe-S biogenesis system, and propose that the a

144 loroplastic Fe-S proteins, as well as to the cytosolic Fe-S biogenesis system, and that uncoupling th

145 Here, we report that the cytosolic flavoprotein, NAD(P)H quinone dehydrogenase 1

146 Chromatograms of cytosolic flow-through solutions exhibited iron species

147 nophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate

148 alterations in their electrical activity and cytosolic free Ca(2+) oscillations.

149 Scribble links Cdc42 and the cytosolic functions of the Hippo signaling cascade in HS

150 rimarily for nucleotide synthesis, producing cytosolic glutamate.

151 nditions induce the nuclear translocation of cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC

152 Here, we show that the cytosolic Gram-negative bacterium Shigella flexneri stal

153 Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that

154 that MAO metabolism of DA does not increase cytosolic H(2)O(2) but leads to mitochondrial electron t

155 Nuclear/cytosolic HDAC4 expression ratio was decreased by 3-Hz p

156 e CaMKII-hyperphosphorylation and nuclear-to-cytosolic HDAC4 shift caused by 3-Hz pacing.

157 forming the two Ca(2+)-binding sites and the cytosolic headpiece mediating ATP hydrolysis.

158 allosteric inhibitor JG98, that targets the cytosolic Hsp70 chaperone/co-chaperone complex, can sign

159 Only a few cytosolic HSP70 genes showed greater transcription, with

160 We propose that targeting the cytosolic Hsp70 system by allosteric regulation of its c

161 Cytosolic hybrid histidine kinases (HHKs) constitute maj

162 o-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)).

163 ebae to rapidly degrade glycogen to generate cytosolic hyper-glucose.

164 We found that the majority of LVS remained cytosolic in the absence of immune pressure, eventually

165 In RSV- or HMPV-infected cells, cytosolic inclusion bodies containing the nucleoprotein,

166 NUB1 localized to cytosolic inclusions with pathological forms of tau, as

167 he cells with latrunculin A, Inp1-GFP became cytosolic, indicating that Inp1 localization is dependen

168 NLRP1 and NOD2 are cytosolic innate immune proteins known to generate an im

169 t (Saccharomyces cerevisiae) responds to low cytosolic iron by up-regulating the expression of iron i

170 s a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron

171 de novo heme synthesis and does not contain cytosolic iron-storage proteins.

172 ockdown was rescued by the expression of the cytosolic isoform of yeast CAE, even though it was not i

173 derived macrophages (BMMs) exhibit defective cytosolic killing of L. monocytogenes We further showed

174 th various transcription factors and a nodal cytosolic kinase involved in insulin signaling.

175 e therapeutically, by targeting the expanded cytosolic labile iron pool (LIP) of the cancer cell.

176 , as well as a general enrichment within the cytosolic leaflets of the Golgi complex, peroxisomes, an

177 alectin-3 (Gal3), a beta-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and auto

178 g domains (RBDs), binds to and maintains the cytosolic levels of 14-3-3zeta mRNA, and is, therefore,

179 ]cholesterol-loaded macrophages-including in cytosolic lipid droplets of SMCs.

180 o form cholesteryl esters that coalesce into cytosolic lipid droplets.

181 Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cel

182 essed in HEK 293 cells showing a homogeneous cytosolic localization and was also targeted to the mito

183 and expression of GFP-fused protein indicate cytosolic localization of PfISN1 and expression in asexu

184 ught to not react with self DNA owing to its cytosolic localization(2,12,13); however, recent studies

185 ent manner to a motif present in the central cytosolic loop of NCKX4 and was abolished by the double-

186 ging them with fluorescent proteins in their cytosolic loops.

187 recently discovered pro-inflammatory role of cytosolic LPS, our data reveal a distinct mode of LPS ac

188 The top hit of the screen is the cytosolic Malic Enzyme (ME1), that is sufficient to enab

189 aches to estimate the surface charges of the cytosolic membranes of various organelles in situ in int

190 is allosterically inhibited by a downstream cytosolic metabolite in the MK biosynthesis pathway.

191 pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabiliz

192 In the absence of light, the iLID-RTK is cytosolic, monomeric, and inactive.

193 Human cytosolic monothiol glutaredoxin-3 (GLRX3) is a protein

194 no acids at the N terminus, give rise to the cytosolic MPST1 and mitochondrial MPST2 isoforms.

195 Cytosolic mRNA translation is subject to global and mRNA

196 Cytosolic mtDNA activated the cGAS/STING/IRF3 pathway, s

197 enzyme, Aifm2 oxidizes NADH to maintain high cytosolic NAD levels in supporting robust glycolysis and

198 onsequences of directly lowering the hepatic cytosolic NADH/NAD(+) ratio in mice.

199 ls as a robust marker of an elevated hepatic cytosolic NADH/NAD(+) ratio, also known as reductive str

200 Upon IL8 stimulation, cytosolic NADP(+) is transported to acidified endolysoso

201 oss-talk between endosomal TLR signaling and cytosolic NLR activation with significant implications f

202 on-productive uptake, and those that measure cytosolic/nuclear penetration, which represents only pro

203 O(2) -activating Cu(I) /Cu(II) complexes for cytosolic/nuclear targets are generally not stable again

204 ron responses to mycobacterial pathogens and cytosolic nucleic acid agonists.

205 athways that originate from the detection of cytosolic nucleic acid species, one of the most prominen

206 ression following M. tuberculosis infection, cytosolic nucleic acid transfection, and IFN-beta treatm

207 nd suppression of the interferon response to cytosolic nucleic acids.

208 The loss of HIPK2 leads to higher cytosolic Parkin protein levels at basal conditions and

209 cation and protection from detection by host cytosolic pattern recognition receptors.

210 invaders are sensed either directly, through cytosolic pattern-recognition receptors specific for bac

211 ase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M

212 We found that the membrane-bound cytosolic peptides of FtsN and FtsQ co-migrated with tre

213 In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promo

214 We found that cytosolic PGD1 and PGD2 isozymes have heat-stable activi

215 ular proton (H(+)) and anion fluxes, reduced cytosolic pH, reduced tip-to-shank proton gradients, and

216 efining the spatial and temporal profiles of cytosolic pH, thereby controlling downstream pH-dependen

217 ellular carcinoma (HCC) cells phosphorylates cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), th

218 r order assemblies of 5-LO and FLAP included cytosolic phospholipase A(2) (cPLA(2)) and were linked t

219 ransport chain (ETC) derived H(2)O(2) versus cytosolic phospholipase A(2) (cPLA(2)) derived LOOHs in

220 and then measuring the subsequent change in cytosolic Pi concentration over time.

221 High-resolution mapping of cytosolic Pi concentrations in different cells, tissues,

222 sequestration corresponded with steady-state cytosolic Pi concentrations.

223 yed altered immunometabolism, with increased cytosolic PKM2 (pyruvate kinase M2), phosphorylated PKM2

224 This complex, stabilized by cytosolic plant-conserved regions and helical exchange w

225 secreted HCV RNA derives from intracellular cytosolic plus-strand RNA, but subsequently secreted HCV

226 This effect depends on the predominant cytosolic polarization of Yap1 through a PDZ domain-medi

227 charged, unmodified Tau that is condensed by cytosolic polyanions but negatively charged, hyperphosph

228 that positively charged Tau is condensed by cytosolic polyanions.

229 hyperphosphorylated Tau that is condensed by cytosolic polycations.

230 nce of D- and L-alanine might be linked with cytosolic pool of D and L-glutamate, thereby coupling pr

231 Mechanistically, we found that a cytosolic pool of human methionine sulfoxide reductase B

232 hat down-regulating PLCbeta1 or reducing its cytosolic population by activating Galphaq to localize i

233 his plasma membrane function, PLCbeta1 has a cytosolic population that helps to drive the differentia

234 e implicated conserved basic residues in the cytosolic portions of beta- and gamma-ENaC subunits as b

235 Both TOMM34 and 14-3-3 participated in cytosolic precursor protein transport mediated by the co

236 nes and achieve up to 125-fold increase over cytosolic production.

237 Large cytosolic protein aggregates are removed by two main cel

238 we show that HRI controls autophagy to clear cytosolic protein aggregates when the ubiquitin-proteaso

239 ylation and thus affecting the status of the cytosolic protein synthesis apparatus.

240 FL1 appears to be an example of a eukaryotic cytosolic protein that has been coopted for a function i

241 Parkin is a mostly cytosolic protein, but is rapidly recruited to damaged m

242 h altered ubiquitin-dependent degradation of cytosolic proteins and regulation of protein synthesis d

243 signals early in life can protect the aging cytosolic proteome by tailoring HSF-1 activity to prefer

244 ich collectively drive a shift toward a more cytosolic proteome in C9-HRE cells.

245 This imposes a severe challenge to cytosolic proteostasis and triggers a specific transcrip

246 Mitochondrial and cytosolic proteostasis are of central relevance for cell

247 In turn, mitochondria facilitate cytosolic proteostasis.

248 se assemblies form after attachment of short cytosolic protofilaments, which we estimate to be less t

249 mory by preventing delayed activation of the cytosolic PRR NLR pyrin domain 3 (NLRP3) that would othe

250 Here, we show that the cytosolic PRR Nod-like Receptor CARD 4 (NLRC4) suppresse

251 pyruvate in the low micromolar range, below cytosolic pyruvate, which means that the mitochondrial p

252 al NADH oxidation reaction the generation of cytosolic pyruvate.

253 o unify the seemingly distinct mitochondrial-cytosolic quality control mechanisms into a single netwo

254 imetic version of Rab7-S72 exhibited diffuse cytosolic Rab7 localization and enhanced innate immune s

255 t insight into the in vivo dynamics of plant cytosolic redox metabolism.

256 ut except for GSSG, only weakly affected the cytosolic redox state.

257 indicate high conformational dynamics of the cytosolic region that regulate NADPH/NADP(+) exchange.

258 Notably, cytosolic replication in untransformed cells from both s

259 rphic sequences adjacent to NLS1 may enhance cytosolic retention, which has clinical implications for

260 RIG-I-like receptors (RLR) are cytosolic RNA sensors that signal through the MAVS adapt

261 ract with distinct interfaces within channel cytosolic segments, suggesting that functional Ca(2+) re

262 Cytosolic sensing of pathogens and damage by myeloid and

263 The NAIP/NLRC4 inflammasome is a cytosolic sensor of bacteria that activates caspase-1 an

264 Mechanistically, MAARS knockdown alters HuR cytosolic shuttling, regulating HuR targets such as p53,

265 sis pathway, O antigens are assembled on the cytosolic side of the inner membrane on a lipid anchor a

266 3 and the noncanonical ankyrin domain in the cytosolic side of the inward-rectifier K(+) channel AKT1

267 ults demonstrate that mHTT is located on the cytosolic side of the mitochondrial outer membrane (MOM)

268 Alternatively, this can occur from the cytosolic side of the plasma membrane after phagosomal r

269 targets specific phospholipids found on the cytosolic side of the plasma membrane.

270 ss to the pore is through a vestibule on the cytosolic side that is fenestrated by side portals.

271 be required for assembly and progression of cytosolic signaling networks in mammalian cells.

272 l 1,4,5-triphosphate receptor (IP3R)-induced cytosolic signals is based on attenuating store-operated

273 ed oxidants may causatively link nuclear and cytosolic sirtuin inhibition to aging-related inflammato

274 ns Sirt1 and Sirt6, as well as the primarily cytosolic sirtuin Sirt2, are modified and inhibited by c

275 We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors.

276 CesA's N-terminal domains assemble into a cytosolic stalk that interacts with a microtubule-tether

277 r data and previous characterisations of the cytosolic state of NTAc-alphaS clarify that the role of

278 ted isoform-specific inhibitors of the human cytosolic sulfotransferase 1A3 (SULT1A3)-the isoform res

279 Sulfotransferase 4A1 (SULT4A1) is a cytosolic sulfotransferase that is highly conserved acro

280 erous accessory proteins associated with the cytosolic surface of lysosomes.

281 -associated molecular patterns are abundant, cytosolic surveillance systems such as STING are well po

282 of IL-1beta production can evade macrophage cytosolic surveillance systems, including cGAS and the i

283 membrane (TM) protein with a 97-residue-long cytosolic tail (CT).

284 ecruitment of alpha-catenin, and linking its cytosolic tail to the transmembrane domain.

285 onphysiologically cause K-PPn of nuclear and cytosolic targets.

286 synthesis and reduction of trypanothione are cytosolic, the molecular basis of the thiol redox homeos

287 reversible regulatory switch that represses cytosolic translation globally.

288 uclear transcription and RNA processing from cytosolic translation(1).

289 membrane permeabilization and mycobacterial cytosolic translocation and virulence.

290 brane, resulting in attenuated mycobacterial cytosolic translocation and virulence.

291 ole in phagosome rupture and M. tuberculosis cytosolic translocation but also function as modulators

292 for mycobacterial escape from phagosomes and cytosolic translocation.

293 n of SLG1 (Slender Guy 1), which encodes the cytosolic tRNA 2-thiolation protein 2 (RCTU2) in rice.

294 Consequently, there is a reduction in cytosolic Trp in IFN-gamma-activated host cells.

295 nine transmembrane segments, which enclose a cytosolic tunnel and a transmembrane tunnel that converg

296 This complex cooperates with cytosolic ubiquitin ligase UBE3C and p97 ATPase in degra

297 se heme-regulated inhibitory (HRI) induced a cytosolic unfolded protein response to prevent aggregati

298 A gap between the cytosolic vestibule and intramembrane groove provides a

299 P3 in the regulation of the host response to cytosolic viral RNA in myeloid cells.

300 Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like