ライフサイエンスコーパス: cytosolic phospholipase

1 PCR and gene silencing experiments show that cytosolic phospholipase 2 (cPLA2) is the key enzyme medi

2 Activation of cytosolic phospholipase A(2 )(cPLA(2)) is a prerequisite

3 on ([Ca(2+)](i)) by the fura-2 ratio method, cytosolic phospholipase A(2) (cPLA(2)) activation and P-

4 activated protein kinase (MAPK) isoforms and cytosolic phospholipase A(2) (cPLA(2)) activation in hum

5 he current study, we have probed the role of cytosolic phospholipase A(2) (cPLA(2)) activity in the c

6 ed with increased expression and activity of cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenas

7 ls is associated with elevated expression of cytosolic phospholipase A(2) (cPLA(2)) and cyclooxygenas

8 cascades are responsible for this response: cytosolic phospholipase A(2) (cPLA(2)) and diacylglycero

9 d the binding of the C2 domains of group IVa cytosolic phospholipase A(2) (cPLA(2)) and protein kinas

10 ated MIN6 beta-cells that stably overexpress cytosolic phospholipase A(2) (cPLA(2)) and show a ninefo

11 Both the constitutive Group IV cytosolic phospholipase A(2) (cPLA(2)) and the inducible

12 tic signaling events, we studied the role of cytosolic phospholipase A(2) (cPLA(2)) and the Jak/STAT

13 r order assemblies of 5-LO and FLAP included cytosolic phospholipase A(2) (cPLA(2)) and were linked t

14 Cyclooxygenase 2 (COX-2) and cytosolic phospholipase A(2) (cPLA(2)) are the crucial r

15 Here, we identify cytosolic phospholipase A(2) (cPLA(2)) as a central mole

16 ation of BK channels in GH(3) cells involves cytosolic phospholipase A(2) (cPLA(2)) as a potential pr

17 In the present work, we have identified cytosolic phospholipase A(2) (cPLA(2)) as an effector mo

18 th negatively charged phospholipids, and the cytosolic phospholipase A(2) (cPLA(2)) C(2) domain, whic

19 Cytosolic phospholipase A(2) (cPLA(2)) comprises a widel

20 ransport chain (ETC) derived H(2)O(2) versus cytosolic phospholipase A(2) (cPLA(2)) derived LOOHs in

21 We have previously reported that cytosolic phospholipase A(2) (cPLA(2)) expression and ac

22 , we have demonstrated that STAT-3-dependent cytosolic phospholipase A(2) (cPLA(2)) expression is nee

23 The group IV cytosolic phospholipase A(2) (cPLA(2)) has been localize

24 Group IV cytosolic phospholipase A(2) (cPLA(2)) has been shown to

25 e demonstrated a crucial regulatory role for cytosolic phospholipase A(2) (cPLA(2)) in monocyte chemo

26 holine (LPC), catalyzed by the activation of cytosolic phospholipase A(2) (cPLA(2)) in the PPT1-KO mo

27 phosphorylation by Ang II was attenuated by cytosolic phospholipase A(2) (cPLA(2)) inhibitor pyrroli

28 Cytosolic phospholipase A(2) (cPLA(2)) is a Ca(2+)-sensi

29 Cytosolic phospholipase A(2) (cPLA(2)) is a key enzyme i

30 s of human calcium-independent (iPLA(2)) and cytosolic phospholipase A(2) (cPLA(2)) lipase activity r

31 examined the effect of deleting the group IV cytosolic phospholipase A(2) (cPLA(2)) locus (Pla2g4).

32 The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) mediates agonist-

33 The 85-kDa cytosolic phospholipase A(2) (cPLA(2)) plays an importan

34 Cytosolic phospholipase A(2) (cPLA(2)) releases arachido

35 lling via a cAMP-independent mechanism, i.e. cytosolic phospholipase A(2) (cPLA(2)) signalling.

36 es whether 5LO interacts with the membranous cytosolic phospholipase A(2) (cPLA(2)) to produce leukot

37 Ca(2+) concentrations ([Ca(2+)](i)) promote cytosolic phospholipase A(2) (cPLA(2)) translocation to

38 tudy, we demonstrate that down-regulation of cytosolic phospholipase A(2) (cPLA(2)) using RNA interfe

39 of p38 MAPK, ERK-1/2, and [Ca(2+)]-dependent cytosolic phospholipase A(2) (cPLA(2)) was determined in

40 coupling the receptor-mediated activation of cytosolic phospholipase A(2) (cPLA(2)) with isotetrandri

41 ination, substantially altered the levels of cytosolic phospholipase A(2) (cPLA(2)), 5-lipoxygenase (

42 kinase II), a decoder of Ca(2+) signals, and cytosolic phospholipase A(2) (cPLA(2)), an enzyme involv

43 /2 by EGF was followed by phosphorylation of cytosolic phospholipase A(2) (cPLA(2)), and blocking ERK

44 We have used RT-PCR to identify mRNAs for cytosolic phospholipase A(2) (cPLA(2)), COX-1, COX-2, 5-

45 also interacts with the C-terminal region of cytosolic phospholipase A(2) (cPLA(2)), inhibiting cPLA(

46 To apply this approach to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)), single cysteines

47 tors of transcription (Jak/STAT) pathway and cytosolic phospholipase A(2) (cPLA(2)).

48 ond messenger in the apoptotic activation of cytosolic phospholipase A(2) (cPLA(2)).

49 c dyad and an active site like that of human cytosolic phospholipase A(2) (cPLA(2)).

50 (CaM)-dependent protein kinase II-dependent cytosolic phospholipase A(2) (cPLA(2)).

51 tions results from the activity of a type IV cytosolic phospholipase A(2) (cPLA(2)).

52 nding of two Ca(2+) ions to the C2 domain of cytosolic phospholipase A(2) (cPLA(2)-alpha) induces doc

53 We reported that mice deficient for cytosolic phospholipase A(2) (cPLA(2)-KO) are protected

54 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) catalyzes re

55 Although group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) has been rep

56 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) initiates ei

57 Group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) is regulated

58 P) directly binds to and activates group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) to stimulate

59 lbicans that mediate activation of group IVA cytosolic phospholipase A(2) (cPLA(2)alpha), a regulator

60 ed to study the interaction of C2 domains of cytosolic phospholipase A(2) (cPLA(2)alpha-C2) with a La

61 that in thrombin-stimulated human platelets, cytosolic phospholipase A(2) (cPLA2) is phosphorylated o

62 Activation of group IV cytosolic phospholipase A(2) (gIV-PLA(2)) is the essenti

63 ts indicate that this involves activation of cytosolic phospholipase A(2) (PLA(2)) and eicosanoid syn

64 The results suggest that cytosolic phospholipase A(2) activation triggered by the

65 Upstream, MAPK-p38 mediates cytosolic phospholipase A(2) activation, which is requir

66 e causally associated with the inhibition of cytosolic phospholipase A(2) activity and the PI3K/ERK/N

67 It is postulated that inhibition of cytosolic phospholipase A(2) alpha (cPLA(2)alpha) can re

68 The arachidonic acid-generating enzyme cytosolic phospholipase A(2) alpha (cPLA(2)alpha) has be

69 Cytosolic phospholipase A(2) alpha (cPLA(2)alpha, type I

70 g and the associated augmentation of ERK1/2, cytosolic phospholipase A(2) alpha, and cysteinyl-leukot

71 Phosphorylation of ERK1/2 and cytosolic phospholipase A(2) alpha, known to enhance the

72 nterestingly, expression of COX-2 as well as cytosolic phospholipase A(2) and 5-lipoxygenase were mar

73 rough p38 MAPK-activated c-Src subsequent to cytosolic phospholipase A(2) and generation of AA metabo

74 ted by the concerted actions of the group IV cytosolic phospholipase A(2) and the group V secretory p

75 p38 mitogen-activated protein kinase (MAPK), cytosolic phospholipase A(2) and urokinase type plasmino

76 A(2) expression and activity indicated that cytosolic phospholipase A(2) did not account for AA mobi

77 erexpressed secretory phospholipase A(2) and cytosolic phospholipase A(2) during sepsis benefits the

78 A decrease in both cytosolic phospholipase A(2) expression and activity ind

79 nd associated with increased 5-LO, FLAP, and cytosolic phospholipase A(2) expression.

80 labeling was carried out on the C2 domain of cytosolic phospholipase A(2) in order to determine the d

81 eicosanoids is mediated by the activation of cytosolic phospholipase A(2) in resident peritoneal macr

82 Cytosolic phospholipase A(2) is activated during phagocy

83 moenol lactone, indicating that the group IV cytosolic phospholipase A(2) is also involved in the pro

84 against secretory phospholipase A(2) IIa and cytosolic phospholipase A(2) IVa can inhibit their targe

85 y phospholipase A2 IIa and the other against cytosolic phospholipase A(2) IVa) (Group 4) increased th

86 tors rotenone and oligomycin, but not by the cytosolic phospholipase A(2) or xanthine oxidase inhibit

87 K1/2, the PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather

88 as added, suggesting that a Ca(2+)-dependent cytosolic phospholipase A(2) released the 20-HETE contai

89 d enzymes, namely COX-1, 5-lipoxygenase, and cytosolic phospholipase A(2) were not induced.

90 is required for IL-33 to activate group IVa cytosolic phospholipase A(2) with consequent AA release

91 ke the C2 domain within protein kinase C and cytosolic phospholipase A(2) with unique determinants th

92 ating gene expression and enzyme activity of cytosolic phospholipase A(2), an enzyme that selectively

93 isoenzymes, secretory phospholipase A(2) and cytosolic phospholipase A(2), are overexpressed during s

94 that SCLC cell lines expressed little or no cytosolic phospholipase A(2), COX-1, or COX-2, sulindac

95 IL-13 increases the levels of mRNA encoding cytosolic phospholipase A(2), LTA(4) hydrolase, and 5-LO

96 ar proliferation and survival, activation of cytosolic phospholipase A(2), mast cell degranulation, a

97 following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidoni

98 positive cooperativity for the C2 domain of cytosolic phospholipase A(2), which binds two Ca(2+) ion

99 gnal-related kinase, an upstream effector of cytosolic phospholipase A(2), which was restored by exog

100 ors and with small interfering RNA show that cytosolic phospholipase A(2)-alpha and group IIA secrete

101 mRNA and protein levels), and the action of cytosolic phospholipase A(2)-alpha is required for this

102 he calcium-binding loops of the C2 domain of cytosolic phospholipase A(2).

103 a calcium ionophore, it can be acted upon by cytosolic phospholipase A(2).

104 ylation of p44/42(ERK1/2) or inactivation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha) complet

105 provide the first direct evidence that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contrib

106 We have previously shown that host cytosolic phospholipase A(2)alpha (cPLA(2)alpha) contrib

107 s through the release of arachidonic acid by cytosolic phospholipase A(2)alpha (cPLA(2)alpha) followe

108 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is acti

109 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the

110 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is the

111 a potent and specific activator of group IV cytosolic phospholipase A(2)alpha (cPLA(2)alpha) via int

112 reatment also induced the phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a key

113 nt activation of Smad and phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), a rate

114 noid synthesis proximal to the activation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), the in

115 7LR), and host signaling molecules including cytosolic phospholipase A(2)alpha (cPLA(2)alpha).

116 synthesis in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation.

117 entify the principal splice variant of human cytosolic phospholipase A(2)beta (cPLA(2)beta) (also kno

118 Cytosolic phospholipase A(2)gamma (cPLA(2)gamma) is a ca

119 The enzymatic properties of cytosolic phospholipase A(2)gamma (cPLA(2)gamma), an iso

120 human corneal epithelial (HCE) cells via the cytosolic phospholipase A(2alpha) (cPLA(2alpha)) pathway

121 We recently identified a cytosolic phospholipase A1 activity in bovine brain and

122 We previously purified a cytosolic phospholipase A1 that could catalyze the prefe

123 The C2 domain of cytosolic phospholipase A2 (C2cPLA2) plays an important

124 F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2)), cyclooxygenase 2 (

125 ive of this study was to investigate whether cytosolic phospholipase A2 (cPLA2 ), an important isofor

126 high levels of MYC, we found an increase in cytosolic phospholipase A2 (cPLA2) activity with a prefe

127 on specifically inhibited receptor-dependent cytosolic phospholipase A2 (cPLA2) activity, whereas thi

128 on in VWF/GPIb-IX-induced phosphorylation of cytosolic phospholipase A2 (cPLA2) and consequent thromb

129 cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (C

130 by constitutively high expression of 85-kDa cytosolic phospholipase A2 (cPLA2) and cyclooxygenase 2

131 In contrast, the kinetics of cytosolic phospholipase A2 (cPLA2) and extracellular sig

132 ing findings exist regarding the function of cytosolic phospholipase A2 (cPLA2) and its role in membr

133 rapidly activates the enzymatic activity of cytosolic phospholipase A2 (cPLA2) as at-tested to by ar

134 NE enhanced release of AA via activation of cytosolic phospholipase A2 (cPLA2) but not secretory PLA

135 Cytosolic phospholipase A2 (cPLA2) catalyzes release of

136 The 85-kDa Group IV calcium-dependent cytosolic phospholipase A2 (cPLA2) catalyzes the hydroly

137 Cytosolic phospholipase A2 (cPLA2) catalyzes the selecti

138 Cytosolic phospholipase A2 (cPLA2) catalyzes the selecti

139 This study demonstrates that host cell cytosolic phospholipase A2 (cPLA2) contributes to E. col

140 Cytosolic phospholipase A2 (cPLA2) controls AA generatio

141 We examined the role of cytosolic phospholipase A2 (cPLA2) during human eosinoph

142 The group IV cytosolic phospholipase A2 (cPLA2) exhibits a potent and

143 ase-1 (COX-1), cyclooxygenase-2 (COX-2), and cytosolic phospholipase A2 (cPLA2) expression, the rate-

144 We have used mice in which the gene for cytosolic phospholipase A2 (cPLA2) has been disrupted to

145 Group IVA cytosolic phospholipase A2 (cPLA2) has been shown to pla

146 Cytosolic phospholipase A2 (cPLA2) hydrolyzes the sn-2-a

147 port we examine the phosphorylation state of cytosolic phospholipase A2 (cPLA2) in C3HA fibroblasts t

148 be due to the relatively lower expression of cytosolic phospholipase A2 (cPLA2) in H596 cells than th

149 fies the phosphorylation sites of the 85-kDa cytosolic phospholipase A2 (cPLA2) in human platelets an

150 mediating phosphorylation and activation of cytosolic phospholipase A2 (cPLA2) in intact cells remai

151 rol expression of the arachidonyl-selective, cytosolic phospholipase A2 (cPLA2) in intestinal cells.

152 To investigate the role of cytosolic phospholipase A2 (cPLA2) in regulating the dif

153 The role of cytosolic phospholipase A2 (cPLA2) in the regulation of

154 Cytosolic phospholipase A2 (cPLA2) is a Ca2+-dependent e

155 dependent lipid binding domain of the 85-kDa cytosolic phospholipase A2 (cPLA2) is a homolog of C2 do

156 We have shown previously that cytosolic phospholipase A2 (cPLA2) is able to activate g

157 The C2 domain of cytosolic phospholipase A2 (cPLA2) is involved in the Ca

158 have reported recently that the activity of cytosolic phospholipase A2 (cPLA2) is necessary for the

159 The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for th

160 TNF activation of the 85-kDa cytosolic phospholipase A2 (cPLA2) is thought to be esse

161 erest to know whether arachidonate-releasing cytosolic phospholipase A2 (cPLA2) localizes at lipid bo

162 Cytosolic phospholipase A2 (cPLA2) mediates agonist-indu

163 yotic signal-transducing proteins, including cytosolic phospholipase A2 (cPLA2) of the vertebrate inf

164 No changes in the level of cytosolic phospholipase A2 (cPLA2) or COX-1 were observe

165 GF, but not IGF-I, stimulated MAPK activity, cytosolic phospholipase A2 (cPLA2) phosphorylation, and

166 ticularly the potential contributions of the cytosolic phospholipase A2 (cPLA2) signaling pathway.

167 Translocation of cytosolic phospholipase A2 (cPLA2) to Golgi and ER in re

168 Full-length cytosolic phospholipase A2 (cPLA2) was cloned from U937

169 AA) release and on protein levels of p11 and cytosolic phospholipase A2 (cPLA2) was studied in two ep

170 thway (Ras/Raf/MEK/ERK) and Ca(2+)-dependent cytosolic phospholipase A2 (cPLA2) were activated in chl

171 e phosphorylation sites on the human, 85-kDa cytosolic phospholipase A2 (cPLA2) were identified using

172 triggers the interaction of the C2 domain in cytosolic phospholipase A2 (cPLA2) with the CARD domain

173 e gel electrophoresis immunoblot signals for cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO

174 e, both basal and IL-1-induced expression of cytosolic phospholipase A2 (cPLA2), a key enzyme-regulat

175 on increased phosphorylation and activity of cytosolic phospholipase A2 (cPLA2), an enzyme causing AA

176 g (1) inhibition of nuclear translocation of cytosolic phospholipase A2 (cPLA2), and (2) blockade of

177 rylation of ERKs, whereas phosphorylation of cytosolic phospholipase A2 (cPLA2), and arachidonic acid

178 (Ad5) affects the expression and activity of cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (CO

179 Tissue damage activates cytosolic phospholipase A2 (cPLA2), releasing arachidoni

180 glutamate released during seizures activates cytosolic phospholipase A2 (cPLA2), resulting in P-gp an

181 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release

182 quires protease-activated receptors 1 and 4, cytosolic phospholipase A2 (cPLA2), Src tyrosine kinases

183 ism of calcium-dependent membrane binding of cytosolic phospholipase A2 (cPLA2), we measured the inte

184 ed protein (MAP) kinase in the regulation of cytosolic phospholipase A2 (cPLA2)-mediated AA release b

185 ndent signal involves activation of group IV cytosolic phospholipase A2 (cPLA2).

186 ed human cDNAs encode paralogs of the 85-kDa cytosolic phospholipase A2 (cPLA2).

187 Lysolecithin also activated cytosolic phospholipase A2 (cPLA2).

188 , zymosan, and correlates with activation of cytosolic phospholipase A2 (cPLA2).

189 ghly dependent on previous activation of the cytosolic phospholipase A2 (cPLA2).

190 racts with the carboxyl region of the 85-kDa cytosolic phospholipase A2 (cPLA2).

191 ught to require TNF-activation of the 85-kDa cytosolic phospholipase A2 (cPLA2).

192 mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2).

193 pha caused phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).

194 nic acid (AA) from membrane phospholipids by cytosolic phospholipase A2 (cPLA2).

195 rachidonic acid by phospholipase A2, and the cytosolic phospholipase A2 (cPLA2)alpha isoform has been

196 ular dynamics simulation of the C2 domain of cytosolic phospholipase A2 (cPLA2-C2) in a 1-palmitoyl-2

197 amino-terminal, 138 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) mediates an initia

198 The role of Group IVA cytosolic phospholipase A2 (cPLA2alpha) activation in re

199 Group IVA cytosolic phospholipase A2 (cPLA2alpha) acts as a bridge

200 sion was shown to require activation of host cytosolic phospholipase A2 (cPLA2alpha) by Loops1 and 2

201 There is compelling evidence that group IVA cytosolic phospholipase A2 (cPLA2alpha) targets arachido

202 macrophages through activation of group IVA cytosolic phospholipase A2 (cPLA2alpha).

203 ygous loss-of-function mutation in group IVA cytosolic phospholipase A2 (cPLA2alpha).

204 ptotagmin I (SytIC2A) and the C2 domain from cytosolic phospholipase A2 (cPLA2C2) are among the best

205 The Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is a key provide

206 Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2

207 Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is the rate-limi

208 Phosphorylation and activation of cytosolic phospholipase A2 (PLA2) can occur independentl

209 achidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role

210 activation were observed, whereas ERK1/2 and cytosolic phospholipase A2 (S505) phosphorylation was no

211 Reduced Ca(2+)-dependent cytosolic phospholipase A2 activation and oxidative meta

212 cells, PDGF-induced MAPK activation leads to cytosolic phospholipase A2 activation, PGE2 release, and

213 Increased cytosolic phospholipase A2 activity and lyso-phosphatidy

214 included measurement of prostaglandin E2 and cytosolic phospholipase A2 activity in membrane fraction

215 We further show that MIF regulates cytosolic phospholipase A2 activity via a protein kinase

216 ression of key enzymes in NPD1 biosynthesis, cytosolic phospholipase A2 and 15-lipoxygenase, was alte

217 Similarly, PGF2alpha causes translocation of cytosolic phospholipase A2 and also results in a 7-fold

218 Enhancement was blocked by inhibitors of cytosolic phospholipase A2 and cytochrome P450 epoxygena

219 arachidonic acid from phospholipid stores by cytosolic phospholipase A2 and cytochrome P450 metabolis

220 which is due to a constitutively stimulated cytosolic phospholipase A2 and enhanced basal expression

221 osphorylation and activation of the Group IV cytosolic phospholipase A2 and of the extracellular-sign

222 ll as beta-arrestin1-dependent activation of cytosolic phospholipase A2 and release of arachidonate,

223 ar relevance to studies on the regulation of cytosolic phospholipase A2 as these two MAPKs are capabl

224 d the binding of beta-arrestin1 to activated cytosolic phospholipase A2 as well as beta-arrestin1-dep

225 es upon cell stimulation, and cooperate with cytosolic phospholipase A2 at the membrane surface to ge

226 s NF-kappaBp50/p105, IL-1beta precursor, and cytosolic phospholipase A2 genes.

227 Eicosanoids, derived from the cytosolic phospholipase A2 group IVA (cPLA2alpha) activa

228 ed that an A-->G variant (rs12746200) of the cytosolic phospholipase A2 group IVA gene (PLA2G4A), whi

229 xercised in using AACOCF3 as an inhibitor of cytosolic phospholipase A2 in whole cell assays because

230 Pretreatment of DARas with antioxidants or a cytosolic phospholipase A2 inhibitor also restores the w

231 We also demonstrate that the cytosolic phospholipase A2 inhibitor arachidonyl trifluo

232 In contrast, a specific cytosolic phospholipase A2 inhibitor blocked the oxidant

233 determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl triflu

234 Cells treated with the cytosolic phospholipase A2 inhibitor, cPLA2alpha, had no

235 d (AA) by exposure to fatty acid-free BSA or cytosolic phospholipase A2 inhibitors.

236 Cytosolic phospholipase A2 initiates the biosynthesis of

237 Cytosolic phospholipase A2 is a key regulator of blood-b

238 Cytosolic phospholipase A2 is involved in several signal

239 cells that express tau, receptors coupled to cytosolic phospholipase A2 may activate PLC-gamma isozym

240 Finally, we propose that cytosolic phospholipase A2 may be a potential source of

241 arthritis correlated with altered COX-2 and cytosolic phospholipase A2 messenger RNA levels in the j

242 alpha preferentially activates the MEK-Erk2- cytosolic phospholipase A2 pathway.

243 ed extracellular signal-regulated kinase and cytosolic phospholipase A2 phosphorylation, consistent w

244 ein's ability to induce prostaglandin E2 and cytosolic phospholipase A2 synthesis in patients' fibrob

245 Cytosolic phospholipase A2 translocates from the cytopla

246 pholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) alpha in regulating ei

247 itoneal macrophages, activation of group IVA cytosolic phospholipase A2(cPLA2alpha) by calcium- and m

248 as novel therapeutic targets in cancer (eg, cytosolic phospholipase A2, an upstream target of the cy

249 age-dependent alpha1G subtype Ca2+ channels, cytosolic phospholipase A2, and epoxyeicosatrienoic acid

250 ETE from membrane phospholipids by group IVA cytosolic phospholipase A2, and its conversion to bioact

251 phosphorylation of Raf1, MEK1, p42mapk, and cytosolic phospholipase A2, as well as the associated in

252 AAOCF3, which inhibits cytosolic phospholipase A2, blocked thapsigargin-stimula

253 ether the RvD1 biosynthetic machinery (e.g., cytosolic phospholipase A2, calcium-independent phosphol

254 utamate signaling through the NMDA receptor, cytosolic phospholipase A2, COX-2, and mPGES-1 increases

255 tracellular Ca2+ concentration and activates cytosolic phospholipase A2, followed by lipoxygenase-cat

256 ion of this Ras-MAP kinase pathway activated cytosolic phospholipase A2, leading to the release of ar

257 Finally, inhibition of cytosolic phospholipase A2, one of the key enzymes invol

258 the Ca2+-dependent lipid-binding domains of cytosolic phospholipase A2, protein kinase C, Rabphilin-

259 utocrine loop by which LPI is synthesized by cytosolic phospholipase A2, pumped out of the cell by th

260 noid synthesis proximal to the activation of cytosolic phospholipase A2, the initial rate-limiting st

261 ese two MAPKs are capable of phosphorylating cytosolic phospholipase A2, thereby increasing its intri

262 decrease in expression of MEK1, p42mapk, and cytosolic phospholipase A2, which may contribute further

263 (2+)- and kinase-dependent activation of the cytosolic phospholipase A2, which releases arachidonic a

264 ssion of cyclooxygenase-2 and phosphorylated cytosolic phospholipase A2, which was reflected in prost

265 Cytosolic phospholipase A2-alpha (cPLA2-alpha) is a calc

266 ee functionally distinct signaling proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein

267 iglyceride and free fatty acid content and a cytosolic phospholipase A2-dependent increase in formati

268 FP, but by inhibitors of either secretory or cytosolic phospholipase A2.

269 ctivated by protein kinase C lambda/iota and cytosolic phospholipase A2.

270 P kinases and induces the phosphorylation of cytosolic phospholipase A2.

271 rifluoromethyl ketone, a potent inhibitor of cytosolic phospholipase A2.

272 staglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2/cyclooxygenase-mediated mecha

273 l proliferation; to induce the activation of cytosolic phospholipase A2; and to inhibit Na+-K+-ATPase

274 Cytosolic phospholipases A2 (cPLA2s) consist of a family

275 Secretory and cytosolic phospholipases A2 (sPLA2 and cPLA2) may contri

276 Cytosolic phospholipase A2alpha (cPLA2alpha) affects mem

277 Cytosolic phospholipase A2alpha (cPLA2alpha) has been sh

278 Cytosolic phospholipase A2alpha (cPLA2alpha) hydrolyzes

279 We here studied possible involvement of cytosolic phospholipase A2alpha (cPLA2alpha) in this mec

280 ulin resistance and to determine the role of cytosolic phospholipase A2alpha (cPLA2alpha) in this pro

281 Cytosolic phospholipase A2alpha (cPLA2alpha) is a major

282 arachidonic acid release but did not involve cytosolic phospholipase A2alpha (cPLA2alpha) or calcium-

283 GE2 treatment induced the phosphorylation of cytosolic phospholipase A2alpha (cPLA2alpha), a key enzy

284 ains of protein kinase Calpha (PKCalpha) and cytosolic phospholipase A2alpha (cPLA2alpha), for exampl

285 ceramide kinase is an activator of group IVA cytosolic phospholipase A2alpha (cPLA2alpha), the rate-l

286 Cytosolic phospholipase A2alpha (cPLA2alpha), which init

287 whether there is an association between the cytosolic phospholipase A2alpha (cPLA2alpha)-controlled

288 Group IVA phospholipase A2 [cytosolic phospholipase A2alpha (cPLA2alpha)] is a key m

289 tionship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA ph

290 Generation requires the participation of cytosolic phospholipase A2alpha and CoA-dependent acyltr

291 Moreover, blocking cytosolic phospholipase A2alpha by its inhibitor or smal

292 We propose that cytosolic phospholipase A2alpha, COX-2, and mPGES-1 in t

293 Cytosolic phospholipase A2alpha, which mobilizes arachid

294 of the promoter of its biosynthetic enzyme, cytosolic phospholipase A2alpha.

295 uct was approximately 56% identical to human cytosolic phospholipase A2gamma (cPLA2gamma).

296 quence homology, we named the molecule mouse cytosolic phospholipase A2gamma (cPLA2gamma).

297 Cytosolic phospholipase (cPLA(2))-initiated proinflammat

298 -independent phospholipase (iPLA(2)beta) and cytosolic phospholipase (cPLA(2)alpha), and substantiate

299 Activated cytosolic phospholipase (cPLA2) catalyzes the production

300 Whereas the subcellular locations of cytosolic phospholipase (PL) A(2) and each of the pathwa