ライフサイエンスコーパス: daidzein

1 rgonidin), and isoflavones (e.g., genistein, daidzein).

2 y alcohol (eg, the isoflavones genistein and daidzein).

3 al kinase, was inhibited by equol but not by daidzein.

4 fected daidzin and only temperature affected daidzein.

5 82,780, tamoxifen, raloxifene, genistein, or daidzein.

6 effects of the soy isoflavones genistein and daidzein.

7 3.2 h for free genistein and 4.2 h for free daidzein.

8 istribution were estimated for genistein and daidzein.

9 .2 h for total genistein and 8.2 h for total daidzein.

10 e methylation of the 4' position (B-ring) of daidzein.

11 addition of the isoflavonoids genistein and daidzein.

12 ical recovery was significantly inhibited by daidzein.

13 mmary tumors from mice that received dietary daidzein.

14 account for all of the loss of genistein and daidzein.

15 an IP injection of the caveolin-1 inhibitor, daidzein (0.4 mg/kg), every 24 h following reperfusion.

16 ary isoflavonoids were 0.72 (0.43, 0.96) for daidzein, 0.67 (0.43, 0.91) for genistein, and 0.72 (0.4

17 4(')-glucuronide, 13% monosulfates, 7% free daidzein, 0.9% sulfoglucuronides, 0.4% diglucuronide, an

18 0.46 g/L; genistein: 0.18 g/L) than in ENTI (daidzein: 0.33 g/L; genistein: 0.20 g/L).

19 0.46 g/L; genistein: 0.18 g/L) than in ENTI (daidzein: 0.33 g/L; genistein: 0.20 g/L).

20 eased the conversion of isoflavone in ENTII (daidzein: 0.46 g/L; genistein: 0.18 g/L) than in ENTI (d

21 eased the conversion of isoflavone in ENTII (daidzein: 0.46 g/L; genistein: 0.18 g/L) than in ENTI (d

22 Daidzein (1) is a natural estrogenic isoflavone.

23 Subjects excreted measurable amounts of daidzein (11.6-39.2 mg/day) and genistein (2.9-18.2 mg/d

24 nistein 1271+/-321 versus 425+/-104, P<0.05; daidzein 1304+/-352 versus 292+/-78, P<0.05).

25 l (1.21 g/L), with a significant increase in daidzein (17.05 g/L) and genistein (9.68 g/L).

26 0 mg per g of extract), genistin (3.7 mg/g), daidzein (2.6 mg/g), daidzein-4',7-diglucoside (1.2 mg/g

27 y contained an especially high proportion of daidzein (307gkg(-1)).

28 ), genistin (3.7 mg/g), daidzein (2.6 mg/g), daidzein-4',7-diglucoside (1.2 mg/g), genistein (0.2 mg/

29 y effect was not observed in the presence of daidzein (50 micromol/L), an analogue of genistein that

30 Twenty-five muM daidzein/50 muM genistein and 50 muM daidzein/50 muM gen

31 ive muM daidzein/50 muM genistein and 50 muM daidzein/50 muM genistein significantly increased the ap

32 Except 50 muM daidzein/50 muM genistein, all other combinations had no

33 rphostin A25 and controls, tyrphostin A1 and daidzein (a genistein congener), were inactive despite p

34 are products of gut bacterial metabolism of daidzein, a phytochemical found predominantly in soy.

35 Daidzein, a quercetin analogue that does not inhibit NF-

36 Daidzein, a soy isoflavone, is a clinically approved age

37 (7,3',4'-THIF) is one of the metabolites of daidzein, a well known soy isoflavone, but its chemoprev

38 To understand how genistein and daidzein affect P. savastanoi pv. phaseolicola, non-targ

39 n safety in humans, early and chronic use of daidzein aimed at augmenting ApoE may serve as a novel,

40 m estradiol, 3 microm genistein, or 3 microm daidzein all increased ERalpha expression, stimulated ce

41 Daidzein also elevated the cholesterol homeostasis genes

42 the flavonoids naringenin, eriodictyol, and daidzein also stimulated an increase in the DNA binding

43 Daidzein, an inactive analogue of genistein, fails to en

44 Transport was not affected by daidzein, an inactive genistein analog that does not inh

45 on of equol from the microbial metabolism of daidzein-an observation not yet documented in the US pop

46 ties of the resulting compounds, a series of daidzein analogues have been designed and synthesized.

47 d okara proteinaceous material with 248 ug/g daidzein and 236 ug/g genistein, along with a 3 % increa

48 Stable isotopically labeled [13C(3)]daidzein and [13C(3)]genistein were synthesized and used

49 ting the A-ring 7-hydroxyl of the isoflavone daidzein and a 4'-OMT methylating the B-ring 4'-hydroxyl

50 while increased the contents of daidzin and daidzein and decreased the content of genistein in the u

51 With maturation, the concentrations of daidzein and equol were unaffected, while the glycitein

52 their bioactive compounds, namely genistein, daidzein and equol, on the inflammatory responses induce

53 Daidzein and formononetin degraded primarily by direct p

54 ments using estradiol and the phytoestrogens daidzein and genistein (compounds known to bind ER-beta)

55 Mean daily serum levels of daidzein and genistein (free and conjugated forms) 15 h

56 es in soymilk at 97 degrees C for 25min, the daidzein and genistein aglycone contents were maintained

57 Daidzein and genistein are isoflavones found in soybean.

58 The amounts of daidzein and genistein in the SSF decreased to 8.6 +/- 1

59 The isoflavones daidzein and genistein occur naturally in most soyfoods,

60 Daidzein and genistein showed a synergistic effect on in

61 isoflavone combination with lower levels of daidzein and genistein to be a more efficacious and safe

62 The addition of 0.9% PGA caused 7S, 11S, daidzein and genistein to coacervate following a 1h incu

63 In addition, isoflavones including daidzein and genistein were also coacervated from the SS

64 HPLC analysis suggested that daidzein and genistein were bound to the 7S and 11S prot

65 These results suggested that daidzein and genistein were co-precipitated with the 7S

66 Total hydrolyzed daidzein and genistein were measured against quality ass

67 protein and flaxseed are due to isoflavones (daidzein and genistein), lignans (matairesinol and secoi

68 The anticancer effects of daidzein and genistein, and their combinations on early-

69 ogical activities, and their aglycone forms, daidzein and genistein, are targeted due to their higher

70 ts, and major soy isoflavones, in particular daidzein and genistein, are thought to be the source of

71 th previous findings for the soy isoflavones daidzein and genistein, both of which have relatively po

72 es, and the two main isoflavones of soybean, daidzein and genistein, in their non-glycosylated form.

73 alonyl derivatives, while aglycones, such as daidzein and genistein, remained stable and were detecte

74 tain a significant amount of the isoflavones daidzein and genistein, which are weak estrogens.

75 possibly in part because of the isoflavones daidzein and genistein, which are weakly estrogenic.

76 t coagulant for the coacervation of 7S, 11S, daidzein and genistein.

77 rmentation caused significant changes in the daidzein and glycitein concentrations.

78 chalcone reductase led to very low levels of daidzein and increased levels of genistein, but did not

79 The mean sum of daidzein and its conjugates was within 20% of the hydrol

80 both milk and yogurt samples, the amounts of daidzein and its metabolite equol were significantly hig

81 hanisms of the chemopreventive activities of daidzein and its metabolite, equol, are not understood.

82 citein bioavailability is similar to that of daidzein and its urinary excretion is significantly high

83 These results suggest that dietary daidzein and legumes may contribute to urinary daidzein,

84 The bacterium catabolized genistein and daidzein and responded by producing several different cl

85 thase, thereby preventing its dehydration to daidzein and subsequent A-ring methylation by free IOMT.

86 d tyrphostin 23 and their inactive analogues daidzein and tyrphostin A1, respectively.

87 equol, O-desmethylangolensin, genistein, and daidzein) and lignan (enterodiol and enterolactone) cont

88 er accumulation of formononetin (4'-O-methyl daidzein) and medicarpin in the leaves than does elicita

89 n A was composed of 90 +/- 5% genistein, 10% daidzein, and 1% glycitein.

90 ulation B was composed of 43% genistein, 21% daidzein, and 2% glycitein.

91 Pure soy isoflavones (genistein, genistin, daidzein, and biochanin A) and soy phytochemical concent

92 In contrast, soybean isoflavones (genistein, daidzein, and biochanin A) are ERbeta-selective agonists

93 soy isoflavone phytoestrogens, genistein and daidzein, and equol (a daidzein metabolite produced by i

94 The elimination rates (k(e)) for genistein, daidzein, and equol were 0.1, 0.16, and 0.08 h(-1), resp

95 Recoveries of conjugates of genistein, daidzein, and equol were 24%, 66%, and 28% of the amount

96 hanisms by which soy isoflavones (genistein, daidzein, and equol) afford protection against oxidative

97 rminal plasma half-lives for free genistein, daidzein, and glycitein averaged 3.8, 7.7, and 3.4 h, re

98 soflavone preparations containing genistein, daidzein, and glycitein in postmenopausal women.

99 105.23 mg total isoflavones/d as genistein, daidzein, and glycitein in their natural ratios and incr

100 zein or combined soy isoflavones (genistein, daidzein, and glycitein) increased primary mammary tumor

101 studies of purified unconjugated genistein, daidzein, and glycitein, and defined pharmacokinetic par

102 isoflavone mixture consisting of genistein, daidzein, and glycitein.

103 ze S-equol from the precursor soy isoflavone daidzein, and it is significant that, unlike R-equol, th

104 -2-aminopropane (DOI), SRT1720, resveratrol, daidzein, and metformin produced mitochondrial biogenesi

105 d the plasma concentrations of genistein and daidzein, and the intestinally derived metabolite, equol

106 contained mainly glycosides of genistein and daidzein, and the total isoflavone content was similar a

107 The isoflavones genistein, daidzein, and their glycosides, found in high concentrat

108 Daidzein, another phytoestrogen, was ineffective, but eq

109 Indeed, daidzein appears to be safe as it has been widely consum

110 Puerarin, daidzin, and daidzein are 3 major isoflavonoid compounds isolated fro

111 Genistein and daidzein are biologically active isoflavones that are es

112 stinal absorption, circulating genistein and daidzein are eliminated primarily by the kidneys.

113 The soy isoflavones genistein and daidzein are found in blood and tissues as aglycones, gl

114 Genistein and daidzein are isoflavonoid phytoalexins that increase rap

115 Genistein and daidzein are two estrogenic compounds derived from plant

116 Isoflavones, such as genistein and daidzein, are metabolized by microbes to bioactive metab

117 This screen identified daidzein as a transcriptional inducer of Arg1.

118 Daidzein, at 10 degrees C, rose significantly from about

119 ansformation was inhibited by equol, but not daidzein, at noncytotoxic concentrations in a dose-depen

120 henol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabe

121 abundant flavonoids and isoflavones such as daidzein, biochanin A, and 7,3'-dimethoxy-5,6,4' trihydr

122 ncreased the amount of daidzin, genistin and daidzein, but decreased that of genistein.

123 n, genistein was always better taken up than daidzein by both LNCaP and C4-2B cells.

124 allate, epigallocatechin gallate, genistein, daidzein, caffeic acid, gallic acid) in human milk.

125 In contrast, a compound (daidzein) chemically unrelated to PD 098059 had little e

126 ytoestrogen levels in red clover but reduced daidzein concentration by 43%.

127 Subjects with log10 (urinary equol to daidzein concentration) > - 1.5 were classified as EP.

128 Genistein and daidzein concentrations (0.03mg/100g) were similar in bo

129 e accuracy of the quantitation of the intact daidzein conjugates.

130 at received the basal diet, as the precursor daidzein contributed to the increased equol concentratio

131 on of activator protein-1 and c-fos, whereas daidzein did not exert any effect when tested at the sam

132 F expression in tumor extracts of mice after daidzein diets is associated with protein expression of

133 y-induced synaptic remodeling, we found that daidzein enhanced the cholesterol homeostasis genetic pr

134 However, the daidzein-enhanced functional benefits and synaptophysin

135 We examined the interactions of genistein, daidzein, equol, and liquiritigenin with estrogen recept

136 e photochemical behaviors of the isoflavones daidzein, formononetin, biochanin A, genistein, and equo

137 Genistein and daidzein (free and total) were rapidly cleared from plas

138 tural requirements for the transformation of daidzein from an ER agonist to an antagonist.

139 labilities of both total genistein and total daidzein from each of the 2 formulations were not signif

140 In contrast, genistein and daidzein functioned as PPARgamma agonists while also dis

141 were treated with varying concentrations of daidzein, genistein (25-200 muM) or their combinations (

142 in soy drink and appearance of the aglycones daidzein, genistein and glycitein.

143 ng each soya diet period for the analysis of daidzein, genistein, and 2- and 16alpha-hydroxyestrone.

144 ndicative of a soy-based diet, particularly, daidzein, genistein, and equol.

145 roxydeoxybenzoin, and the external standards daidzein, genistein, and genistin.

146 tions of 12 isoflavone isomers, 3 aglycones (daidzein, genistein, and glycitein), and 9 glucosides (d

147 When the daidzein, genistein, and kaempferol were added to artifi

148 Three flavonoid compounds (daidzein, genistein, and kaempferol) were uniquely found

149 idzein and legumes may contribute to urinary daidzein, genistein, and ODMA concentrations in this low

150 ts, and seeds were significant correlates of daidzein, genistein, and ODMA concentrations; and soy le

151 0.48 (0.29, 0.61), and 0.50 (0.32, 0.64) for daidzein, genistein, and TIFLs, respectively.

152 n from 24-h recalls and urinary excretion of daidzein, genistein, and TIFLs.

153 mpounds, three of which are aglycons, namely daidzein, genistein, biochanin A, and two of which, daid

154 Herein, we develop a new strategy to isolate daidzein, genistein, daidzin and genistin in soybean.

155 ontrols were analyzed for isoflavonoids (ie, daidzein, genistein, equol, and O-desmethylangolensin) a

156 ication of 6 isoflavones (daidzin, genistin, daidzein, genistein, formononetin and biochanin A) and 3

157 the predominant phytoestrogen species, with daidzein, genistein, formononetin, and coumestrol presen

158 esinol, lariciresinol, sum of plant lignans, daidzein, genistein, formononetin, naringenin, equol, su

159 ment for several covariates, high intakes of daidzein, genistein, glycetin, secoisolariciresinol, tot

160 We monitored the isoflavones daidzein, genistein, glycitein, formononetin, and biocha

161 Daidzein, genistein, kaempferol, and coumestrol (group 2

162 peated 24-h recalls and urinary excretion of daidzein, genistein, total isoflavonoids (TIFLs), and eq

163 For daidzein sulfate, genistein sulfate, daidzein glucuronide, and genistein glucuronide, the tim

164 neous determination of isoflavone aglycones (daidzein, glycitein and genistein), their corresponding

165 sof (NovasoyR 400: 352 mg Isof/g; Genistein, Daidzein, Glycitein ratio of 1.3:1:0.15 identical to tha

166 ds were analyzed for isoflavones (genistein, daidzein, glycitein, biochanin A, and formononetin), lig

167 40% soybean isoflavones, on the contents of daidzein, glycitein, genistein, and equol in milk as wel

168 leation, with the effects of estrogen > or = daidzein > genistein.

169 +/- SEM) of isoflavonoid excretion in urine (daidzein > glycitein > genistein) and the quantity of is

170 Despite the absence of neuroprotection, daidzein improved motor/gait function in chronic stroke

171 covered that an FDA-approved soy isoflavone, daidzein, improved stroke-induced behavioral deficits vi

172 nide and sulfate conjugates of genistein and daidzein in humans after the consumption of a drink made

173 en to assess the metabolism of genistein and daidzein in patients with end-stage renal disease (ESRD)

174 The percentages of sulfates of genistein and daidzein in plasma (8% and 26%, respectively) were 2- to

175 udo half-lives for total genistein and total daidzein in plasma averaged 10.1 and 10.8 h, respectivel

176 mation of the concentration of genistein and daidzein in sunlit surface waters, which will allow for

177 (SD) plasma concentrations of genistein and daidzein in the seven infants fed soy-based formulas wer

178 FS resulting in production of the isoflavone daidzein in this system.

179 s, methylates the A-ring 7-hydroxyl group of daidzein in vitro, a reaction that probably does not occ

180 cell lines show that some of the effects of daidzein in vivo can be recapitulated by the daidzein me

181 onal isoflavones, including formononetin and daidzein, in response to UV-B or Phoma medicaginis, wher

182 In contrast to canonical Arg1 activators, daidzein increases Arg1 without increasing CREB phosphor

183 For daidzein, individual ORs were 5-38% lower.

184 knock-out mice, suggesting the importance of daidzein-induced ApoE upregulation in fostering stroke r

185 Dissociation between daidzein-induced functional benefits and the absence of

186 rimed in vivo by intrathecal or subcutaneous daidzein infusion.

187 None of the tyrphostins, including A47, nor daidzein inhibited resorption to >20 micromol/L.

188 Agricultural herbicides and daidzein inputs were primarily via upstream routes with

189 ly correlated (P for trend < 0.001) than was daidzein intake (P = 0.011).

190 Daidzein intake and consumption frequency of grain produ

191 he question of the relative contributions of daidzein intake and gut metabolism to equol and of equol

192 Milk and milk product consumption and daidzein intake, but not legumes, were significant corre

193 Genistein and daidzein intakes were highly correlated (r = 0.98); ther

194 r, we observed the further transformation of daidzein into O-desmethylangolensin (O-DMA) and tetrahyd

195 Exposure to genistein and daidzein is calculated from 140 measurements in 9 catego

196 The soy isoflavone daidzein is metabolized to equol and O-desmethylangolens

197 nd isotope dilution studies now confirm that daidzein is not an intermediate in isoflavonoid phytoale

198 rs and sensitizers, and results suggest that daidzein is transformed mainly via direct photolysis and

199 nverts the isoflavone daidzein to 7-O-methyl daidzein (isoformononetin) in vitro as well as in vivo i

200 Finally, genistein and daidzein levels were measured before and after dialysis

201 la is adapted to tolerate bean genistein and daidzein, likely sensing the compounds as host signals a

202 Glucuronides of genistein and daidzein made up a significantly lower percentage (P < 0

203 weakly estrogenic isoflavones genistein and daidzein may alter the metabolism of 17beta-estradiol to

204 at equol, a metabolite of the soy isoflavone daidzein, may advance breast cancer potential via up-reg

205 Serum isoflavone concentrations increased (daidzein mean difference SD: 128 113 ng/mL, P < 0.001; g

206 ietary food groups to urinary isoflavone and daidzein metabolite concentrations in a representative s

207 daidzein in vivo can be recapitulated by the daidzein metabolite equol.

208 rogens, genistein and daidzein, and equol (a daidzein metabolite produced by intestinal microflora) a

209 The predominant daidzein metabolites produced by human intestinal bacter

210 We evaluated relations between daidzein-metabolizing phenotypes and demographic, anthro

211 hromatography-mass spectrometry to determine daidzein-metabolizing phenotypes.

212 onnaire or food record, were associated with daidzein-metabolizing phenotypes.

213 st beneficial health effects associated with daidzein-metabolizing phenotypes; thus, assessing their

214 of hydrolysis of five isoflavone conjugates (daidzein, O-desmethylangolensin, equol, genistein, and g

215 eloped for the analysis of five isoflavones (daidzein, O-desmethylangolensin, equol, genistein, and g

216 ratrol and the soy isoflavones genistein and daidzein on adipogenesis were examined in cell-based ass

217 e current study investigates the efficacy of daidzein on neuroprotection and functional recovery in a

218 We recently demonstrated that dietary daidzein or combined soy isoflavones (genistein, daidzei

219 nists and safe food supplements biochanin A, daidzein or genistein, each rescued the hypotrophic FSHD

220 of either of the major soybean isoflavones, daidzein or genistein, failed to restore normal nodulati

221 Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore

222 oth CNS and PNS neurons primed in vitro with daidzein overcame neurite outgrowth inhibition from myel

223 Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars w

224 Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars w

225 Inhibition of ALDH by daidzein reduced the formation of DOPAC and increased th

226 Mechanistically, daidzein requires transcription and induction of Arg1 ac

227 Genistein, daidzein, rutin, quercetin and trans-resveratrol were al

228 y suggests that the early and chronic use of daidzein serves as a potential strategy to promote funct

229 Daidzin and daidzein shortened alcohol-induced sleep time (loss of r

230 ever, this inhibitory effect was mimicked by daidzein, suggesting that inhibition of tyrosine kinase

231 For daidzein sulfate, genistein sulfate, daidzein glucuronid

232 Daidzein, the other major isoflavone component of soybea

233 for methylation of the A-ring 7-hydroxyl of daidzein, the presumed substrate for O-methylation, in v

234 Except for kaempferol and daidzein, there were no significant associations between

235 (IOMT) from alfalfa converts the isoflavone daidzein to 7-O-methyl daidzein (isoformononetin) in vit

236 ra were cultured in vitro and incubated with daidzein to ascertain the stereospecificity of the bacte

237 subjects consuming both diets could convert daidzein to equol ex vivo.

238 interindividual differences in conversion of daidzein to equol.

239 ere prescreened for their ability to convert daidzein to equol.

240 n transformation of isoflavones (daidzin and daidzein) to equol in soymilk fermented with Bifidobacte

241 blished models in explaining the daidzin and daidzein transformation to equol as a function of pH, te

242 nction, and thyroid economy of genistein and daidzein, two isoflavones in soy infant formula, and exi

243 In vitro, equol, but not daidzein, up-regulated eIF4G without affecting eIF4E or

244 Approximately 30% of the total genistein or daidzein was comprised of mixed conjugates (one glucuron

245 Further, daidzein was effective in promoting axonal regeneration

246 crease in urinary excretion of genistein and daidzein was observed in women but not in men during the

247 Genistein and daidzein were eliminated within 2 d in the healthy subje

248 early morning blood levels of genistein and daidzein were higher in seven dialysis patients than in

249 24 h of fermentation, amounts of daidzin and daidzein were influenced by all factors.

250 glycons of up to 22% of genistein and 18% of daidzein were observed.

251 ectively than the nonselective phytoestrogen daidzein, which effectively reproduced effects of estrog

252 crobial-derived metabolite of the isoflavone daidzein, which is produced in the large intestine after

253 lood levels of the isoflavones genistein and daidzein, while the remaining two-thirds have undetectab

254 ffected by the interaction of the intakes of daidzein with energy or with fiber.