ライフサイエンスコーパス: damage to

1 Notably, GVHD caused irreversible damage to a population of tolerogenic stromal cells that

2 to recognize faces, a classic example of how damage to a specialized brain region can disrupt a speci

3 hat GFI1 acts prior to the occurrence of DNA damage to affect the post-translational modification sta

4 che and Phelipanche, often cause significant damage to agricultural crops.

5 p38 inhibition reduced indomethacin-induced damage to AGSs.

6 rkers of the severity of steatosis and liver damage to aid the identification of high-risk steatotic

7 of a dysregulated host response, followed by damage to alveolar cells and lung fibrosis.

8 Damage to alveoli, the gas-exchanging region of the lung

9 c Lupus Activity Questionnaire; irreversible damage to an organ or system was measured using the Brie

10 ich would enable the brain to compensate for damage to any individual network.

11 Damage to ascending mammillothalamic projections has con

12 lation of co-transcriptional R-loops and DNA damage to avert genomic instability and neurodegeneratio

13 that induced responses can cause patterns of damage to become aggregated, random or even.

14 that high concentrations of FFA can be very damaging to beta-cells when used for in vitro experiment

15 oxygen species that, in addition to causing damage to biological molecules, can also lead to the for

16 ress," whereas at higher intensity, there is damage to biomolecules with potentially deleterious outc

17 In mammals, instability can arise from damage to both copies of genes involved in DNA metabolis

18 Bilateral occlusion produced severe damage to both retinas, while unilateral occlusion produ

19 Osteochondral defects contain damage to both the articular cartilage and underlying su

20 Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, bu

21 ood biomarkers which can accurately indicate damage to brain tissue could yield molecular diagnostics

22 at the remaining three missense variants are damaging to BRSK2 structure and function.

23 l in human participants with focal bilateral damage to CA3.

24 Such dysregulation results in damage to cartilage, a smooth and protective tissue that

25 the inducing signal (for instance, repairing damage to cell components or improving acquisition and u

26 duals who are infected with HIV-1 accumulate damage to cells and tissues (e.g. neurons) that are not

27 is form recalls an accepted model of thermal damage to cells in hyperthermia.

28 LM limits ISG induction, thus connecting DNA damage to cellular innate immune response, which may con

29 Together with damage to central tolerance mechanisms in the thymus, th

30 Most SCA mutations cause prominent damage to cerebellar Purkinje neurons with consecutive c

31 Alcohol consumption by women who parent is damaging to child health, and it is concerning that wome

32 plasts (1.2-1.5-fold), chlorosis, structural damage to chloroplasts and a high seedling mortality rat

33 rdial inflammation and from acute myocardial damage to chronic ventricular dysfunction.

34 Hurricane waves can cause physical damage to coastal ecosystems, re-suspend and transport a

35 e rare, extreme events and cause significant damage to coastal infrastructure, which is often exacerb

36 urable pulmonary vein (PV) isolation without damage to collateral structures.

37 rget bacteria without significant collateral damage to complex microbial communities.

38 ation-specific emissions with these marginal damages to compute economy-wide gross external damage (G

39 high temperature processing that results in damage to conventional polymer substrates.

40 ls progressive lesions starting with limited damage to core systems before invading step-by-step most

41 obligate plant parasites that cause extreme damage to crop plants.

42 Insect damage to crops is a serious issue, in particular when t

43 Specific damage to disulfide bonds is evident early on at RT and

44 mpared with the CD, the PD reduced oxidative damage to DNA (mean: -3.5%; 95% CI: -8.07%, 1.05%; P = 0

45 onic pistachio consumption reduces oxidative damage to DNA and increases the gene expression of some

46 Lessening oxidative damage to DNA and telomerase expression through diet may

47 Oxidative damage to DNA is a threat to the genomic integrity and c

48 and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on c

49 Damage to DNA via dissociative electron attachment has b

50 ration errors but rather is caused by direct damage to DNA.

51 g and erasing mechanism in place, oxidative 'damage' to DNA might be relabeled as 'epigenetic' modifi

52 ructural trajectories arising from oxidative damages to DNA backbone is of crucial importance in unde

53 adiation therapy and chemotherapy induce DNA damage to drive cells into apoptosis or senescence as ou

54 s are catastrophic events that cause massive damage to ecosystems at all trophic levels.

55 Harmful species cause severe damage to ecosystems, biodiversity, agriculture, and hum

56 dysfunction or apoptosis, degradation of or damage to elastic fibers, and pooling of glycosaminoglyc

57 by dicotyledonous plants - cause very minor damage to enamel but are themselves heavily abraded (wor

58 he genes encoding these proteins also causes damage to endolysosomal membranes, consistent with a rol

59 US, aHUS, and secondary HUS are simultaneous damage to endothelial cells, intravascular hemolysis, an

60 ant agents without causing significant acute damage to endothelial or neuronal cells.

61 2017; the Hurricane was also associated with damage to environmental infrastructure such as wastewate

62 obably owing, at least in part, to oxidative damage to enzymes involved in glycolysis, the tricarboxy

63 (GI) colonization model, yet induced greater damage to epithelial cells and macrophages in a manner t

64 killed bacterial cells while causing minimal damage to epithelial cells.

65 sage distilled from the discussions was that damage to epithelial surfaces lies at the origin of the

66 atory cytokines suggest inflammation-induced damage to erythrocytes contributes to anemia and splenic

67 ors (PPIs) to reduce gastric acid associated damage to esophageal and airway mucosa.

68 ing, and both factors can increase oxidative damage to essential biomolecules, accelerating the rate

69 st 16 years and has been causing significant damage to eucalypts (Myrtaceae), including Eucalyptus sp

70 idly synthesized from NAD(+) at sites of DNA damage to facilitate repair, but excessive PAR synthesis

71 matter hyperintensities are associated with damage to fibres of any length, but to a higher percenta

72 al for synaptic function, as light-activated damage to, for example, Synaptophysin only compromises s

73 for source of carbon emissions and pervasive damage to forest ecosystems.

74 AMPs differentiate in response to damage to generate new enterocytes, transiently depletin

75 ts lead to mitochondrial dysfunction, severe damage to glial cells, and impaired vision.

76 Structural and functional damage to glycocalyx occurs in various disease states.

77 tack, and eradicate tumor cells with minimal damage to healthy cells have demonstrated promising clin

78 at could undermine repair fidelity and cause damage to healthy chromosomes(1).

79 kinase inhibitors, a full reversal of mtDNA damage to healthy control levels was observed and correl

80 ioactivity can be delivered while minimizing damage to healthy tissue, which may improve therapeutic

81 al drug molecules from the radiation-induced damage to help extend or at least preserve their structu

82 Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HS

83 A model combining damage to high-threshold auditory nerve fibers with incr

84 intravenous administration and non-specific damages to highly proliferating cells, including immune

85 nteract infections but also cause collateral damage to hosts.

86 they should be used when available to reduce damage to human remains.

87 prove the control of insect pest populations damaging to human health and agriculture.

88 ynonymous variants that were predicted to be damaging to identify a single mutation in a biologically

89 its phage propagation by introducing nicking damage to impair phage DNA replication.

90 n order to uncover the mechanisms that cause damage to initiate in the microstructure under macroscop

91 Damage to inner ear generally leads to permanent hearing

92 The H2b(DeltaIEC) mice had DNA damage to intestinal epithelial cells and proliferative

93 aryote known to tolerate CRISPR-Cas-mediated damage to its genome in the WT background; the resulting

94 effector arsenal against the cell types most damaging to its survival.

95 Adnexal injuries (eyelid lacerations and damage to lacrimal apparatus) were recorded in 1265 of 5

96 body sizes, as well as the higher oxidative damage to lipids, contributed to the higher chlorpyrifos

97 reby compromising strategies to reduce photo-damage to live samples.

98 It causes massive damage to livestock worldwide.

99 ution are limited by the potential for laser damage to living tissues.

100 Only damage to long-distance connections correlated with a mo

101 oreover compared to short-range connections, damage to long-range connections better explains network

102 Damage to long-range connections was more strongly relat

103 from TcsL toxicity and reduces TcsL-induced damage to lung tissues and the lethality rate in mice.

104 (PLV) contractions, which is associated with damage to lymphatic muscle cells (LMCs), is a biomarker

105 cumulation during ischemia lead to oxidative damage to mammalian organs upon reperfusion.

106 We posit that the extent of upstream damage to mammalian plasma membranes, calibrated by seve

107 ATR inhibition caused DNA damage to manifest as 53BP1 nuclear bodies in daughter G

108 ynamic phosphorylation of DNA-PKcs after DNA damage to mediate NHEJ.

109 The damage to metalloproteins caused by reactive oxygen spec

110 ies abundant in oxidative environments cause damage to mitochondrial DNA, initiating signaling pathwa

111 otes, and could mitigate desiccation-induced damage to model proteins and membranes in vitro.

112 to control bacterial burden, to prevent lung damage, to modulate cytokine production, and to improve

113 ently across nasal membranes without causing damage to mucosa or inducing protein aggregation under p

114 quated to forced marriage, and recognized as damaging to multiple dimensions of female well-being(1,2

115 a method to ameliorate alcohol toxicity and damage to muscle.

116 Without inducing cell death and damage to myofilament structure, CCBs elicited line-spec

117 deling showed that the Thr518Met mutation is damaging to MYRF structure.

118 ughout the United States and cause extensive damage to natural ecosystems, threatened and endangered

119 -operative quality of life due to collateral damage to neighboring structures.

120 Neuropathic pain is believed to arise from damage to nociceptive C fibres in diabetic neuropathy (D

121 Finally, we briefly discuss how chemical damage to noncoding RNAs such as rRNA, tRNA, small nucle

122 s in three other examples of immune-mediated damage to noninfected tissues: Rejecting renal allograft

123 er-specific, upstream regulators, mitigating damage to normal tissue.

124 the received dose and reducing the possible damage to normal tissues.

125 The resulting oxidatively generated damage to nucleic acids, membrane unsaturated lipids, an

126 platin ototoxicity which was associated with damage to OHCs and cochlear synaptopathy.

127 Our results suggest that damage to olfactory sensory neurons (such as from air po

128 o exploit this descending pathway even after damage to one area.SIGNIFICANCE STATEMENT The reticulosp

129 te to hand function following stroke-induced damage to one hemisphere.

130 ual-route model for reading, such as whether damage to one route can be compensated by over-reliance

131 Mechanical damage to, or degeneration of, the lumbar discs can dimi

132 demonstrated that nanoparticles can mitigate damage to organs and patients through a large variety of

133 The true impact and long-term damage to organs such as the lungs after severe acute re

134 However, similar symptoms can arise from damage to other brain regions, and face recognition is n

135 of developing lung fibrosis or irreversible damage to other organs.

136 -induced hearing loss without increasing the damage to outer hair cells (OHCs), but increased synapto

137 genome evolution while minimizing collateral damage to overall chromosome architecture and function.

138 Radical damage to parasite lipids and proteins is perceived to b

139 antidote is critical in preventing permanent damage to patients.

140 tion of the effects of mangroves on averting damages to people and property.

141 t couple ligand binding to endocytic vesicle damage to permit MHC class I antigen presentation of exo

142 tractive formulation platform for preventing damage to pharmaceutical drugs in potential space missio

143 m of necrotic cell death marked by oxidative damage to phospholipids(1,2).

144 in the living retina before and after local damage to photoreceptors.

145 Drought can cause major damage to plant communities, but species damage threshol

146 These viruses cause huge economic damage to poultry production systems and pose a zoonotic

147 a viruses, such as H9N2, cause huge economic damage to poultry production worldwide and are additiona

148 ate proteostasis and mitigate macromolecular damage to promote long-term cellular health.

149 s in response to inflammation and mechanical damage to protect the fetus until parturition.

150 and form EETs at sites of airway epithelial damage to protect the host from infections in patients w

151 ed on known chemical mechanisms of oxidative damage to protein groups, defined by their localization

152 redicted by in silico prediction tools to be damaging to protein function.

153 Usually, mutations causing severe damage to proteins cause congenital cataracts, while mil

154 duction of oxygen to H(2)O(2) can facilitate damage to proteins hence, limits their long-term activat

155 baseline corticosterone and plasma oxidative damage to proteins.

156 mbined HL+HS was accompanied by irreversible damage to PSII, decreased D1 (PsbA) protein levels, and

157 asculature, actively leaving sites of tissue damage to re-home to functional niches in the lung and b

158 In turn, this pollen protease-induced damage to respiratory epithelial cell anchorage resulted

159 eviewing the most abundant types of chemical damage to RNA, including oxidation and alkylation.

160 Expected Annual Damages (EAD) due to direct damage to road and railway assets range from 3.1 to 22 b

161 tamination during rover operations, to evade damage to rover components as brines can be highly corro

162 as a protective agent against electrofusion damage to SCNT embryos.

163 ionally investigated the association between damage to short- and long-range connections with structu

164 : r = -0.219; r = -0.426, respectively) than damage to short-range connections.

165 disorder that shows chronic and progressive damage to skeletal and cardiac muscle leading to prematu

166 DNA damage to skin causes epithelial and dermal hyperplasia,

167 tinocyte cell line and mediated pathological damage to skin explants independently of T cells.

168 nd microneurography may reveal the extent of damage to small unmyelinated nerve fibres that go undete

169 a, it was possible to temporally control the damage to specific SV proteins and assess their conseque

170 ulls or disarticulated petrous bones without damage to surrounding bone, and we argue that they shoul

171 As a result, when there is damage to systems that signal reward, like dopamine and

172 e lesion behaviour mapping demonstrated that damage to temporal-parietal regions impacted the ability

173 the risk of harm through collateral thermal damage to the adjacent healthy tissue.

174 antly improved precision and reduced thermal damage to the adjacent tissue in comparison to conventio

175 After damage to the adult mammalian central nervous system (CN

176 In one patient, damage to the anterior visual pathway resulted in occurr

177 during daytime may cause a yet undetectable damage to the auditory synapse, more so in already damag

178 ngitis (PSC), are frequently associated with damage to the barrier function of the biliary epithelium

179 eper imaging of the material and causes less damage to the biological samples in comparison to conven

180 roup of five humans with selective bilateral damage to the BLA.

181 sory neurons that detect damage or potential damage to the body, are the first stage of communicating

182 quitously present, but it induces noticeable damage to the brain's striatum, thereby affecting motor,

183 rome (MetS) has been associated with chronic damage to the cardiovascular system.

184 r an ultrasonic frequency that minimizes the damage to the catalyst, resulting in its successful reus

185 Furthermore, we discuss the damage to the cell that occurs when these pathways are a

186 ein release but without causing any apparent damage to the cell walls when viewed by microscopy.

187 ly invasive biomarkers of ionizing radiation damage to the CNS that are predictors of late responses

188 Here, we investigate infection-mediated damage to the colonic stem cell compartment and how this

189 in some cases, but issues such as collateral damage to the commensal microbiota and consistency of th

190 the ocular surface that may cause persistent damage to the corneal epithelium.

191 Damage to the corticospinal and reticulospinal tract has

192 Damage to the corticospinal tract is widely studied foll

193 Following damage to the corticospinal tract, both the move and hol

194 onnections are known to strengthen following damage to the corticospinal tract, such as after stroke,

195 effects on TECs link the rATG-induced thymic damage to the delayed T cell reconstitution, witnessed a

196 Hypoxic damage to the developing brain due to preterm birth caus

197 when abnormal experience could cause lasting damage to the developing brain.

198 s include loss of neuronal progenitor cells, damage to the developing vascular system of the brain, a

199 nstream analyses without inducing widespread damage to the DNA.

200 tervention with ART did not fully ameliorate damage to the DRG, specifically to peptidergic neurons.

201 the potential for exposure to cause lasting damage to the environment.

202 cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens.

203 achieving lesion durability and concerns of damage to the esophagus-situated behind the LAPW.

204 accurately evaluated without inflicting any damage to the films.

205 f the colon leads to severe inflammation and damage to the gastrointestinal epithelium due to the pro

206 e to around a third of initial levels due to damage to the gel phase of the electrolyte, but this cou

207 The reconstructions also show damage to the granule coatings caused by sedimentary tra

208 al treatment, potentially causing collateral damage to the gut microbiome of the patient.

209 istence and survival with minimal collateral damage to the healthy host.

210 recruitment of inflammatory cells and acute damage to the heart tissue.

211 sted memory-impaired patients with bilateral damage to the hippocampus and compared their performance

212 rgets with multiple mutations but circumvent damage to the host genome.

213 pathogens efficiently but can inflict severe damage to the host if they over-activate within blood ve

214 different diameters frequently causes severe damage to the host vessels.

215 To avoid damage to the host, the receptor must be capable of disc

216 spread of damage along the axon, restricting damage to the immediate vicinity of plaques.

217 generation of bone powder, and confines the damage to the inner ear region and surface of the petrou

218 oocyst excretion, parasite colonization and damage to the intestinal mucosa, and peak diarrheal symp

219 em to study the effects of radiation-induced damage to the intestine in adults and have identified ms

220 ion in patients without obvious radiographic damage to the joint.

221 autoimmune disease that causes irreversible damage to the joints.

222 iated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis.

223 de to limit the magnitude of immune-mediated damage to the kidney.

224 though EBOV infection results in significant damage to the liver and the adrenal glands, little is kn

225 rtant, as this can help prevent irreversible damage to the liver and, ultimately, hepatocellular carc

226 No damage to the lung, pericardium, heart, or internal thor

227 mbined findings suggest a mechanism by which damage to the medial diencephalon can impact upon learni

228 scal tears have a poor healing capacity, and damage to the meniscus is associated with significant pa

229 rue in immunocompromised patients, where the damage to the microbiota caused by antibiotics can lead

230 ocol may be useful to enhance function after damage to the motor system, such as after stroke.

231 smin gene, which is clinically manifested by damage to the nervous system and retinal degeneration.

232 an early stage (without clinical symptoms of damage to the nervous system) during the search for the

233 gene delivery) without FUS, ameliorates the damage to the nigrostriatal dopaminergic pathway in the

234 ic (protein or gene) delivery attenuates the damage to the nigrostriatal dopaminergic pathway, by all

235 adiation doses in small targets with reduced damage to the normal tissue compared to conventional X-r

236 ive fruit pests which cause serious economic damage to the olive orchards.

237 th profilin allergy present with significant damage to the oral mucosal epithelial barrier, which mig

238 We hypothesize that damage to the outer retina may play a role in triggering

239 Side effects to the ovary include damage to the ovarian reserve, resulting in follicle los

240 ocarbons minimizes the lasting environmental damage to the ozone, with R134a (1,1,1,2-tetrafluoroetha

241 calcium level was very low (3 mg/dl) due to damage to the parathyroid gland during total thyroidecto

242 (aerobic) conditions, allowing any oxidation damage to the peptide beyond the metal-binding site to b

243 ensory neuron-macrophage communication after damage to the peripheral nerve.

244 th causes many anatomical changes, including damage to the periventricular white matter.

245 n an improvement of the conductivity without damage to the PET.

246 Substantial damage to the photochemical apparatus occurs at extreme

247 removing the intracellular pathogen without damage to the placental cell.

248 Stroke damage to the primary visual cortex (V1) causes a loss o

249 tive markers of focal GC-IPL thinning due to damage to the primary visual pathways in children.

250 in rats, morphing electronics caused minimal damage to the rat nerve, which grows 2.4-fold in diamete

251 ed both C5 and LTB(4), preventing structural damage to the retina and a significantly reducing effect

252 Diseases and damage to the retina lead to losses in retinal neurons a

253 serious visual impairment and morphological damage to the retina.

254 w persisted, which may result in longer term damage to the retina.

255 ual exploration.SIGNIFICANCE STATEMENT Focal damage to the right cerebral hemisphere may result in a

256 Damage to the right fusiform face area can disrupt the a

257 the manifestation of spatial deficits after damage to the right hemisphere.

258 r head and neck cancers results in permanent damage to the saliva producing acinar compartment of the

259 iltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry e

260 Permanent damage to the salivary glands and resulting hyposalivati

261 ile also reducing both electron charging and damage to the samples.

262 tein-polymer conjugates within 2 h, avoiding damage to the secondary structure of the protein and pro

263 Furthermore, we observed that LTA caused damage to the skin barrier with substantial loss of fila

264 an mitigate the chronic effects of radiation damage to the skin.

265 production of titanium particles and caused damage to the SLA coating of the implant.

266 The implants were visually evaluated for damage to the SLA coating.

267 allic particles and showed easily detectable damage to the SLA layer.

268 st common cause of vision loss, is caused by damage to the small blood vessels in the retina.

269 ability to prevent substantial inflammatory damage to the small bowel.

270 affect the extent of potential radiotherapy damage to the spine.

271 can be introduced relatively easily without damage to the strained bicyclic cage.

272 veloped, reducing the possibility of thermal damage to the surrounding healthy tissues.

273 ogy sections exhibit only minimal collateral damage to the surrounding tissue and the depth of the ab

274 reat microvessels without causing collateral damage to the surrounding tissue.

275 Damage to the teeth and exposure of the large population

276 Toothache is a common painful consequence of damage to the teeth, particularly when coupled to infect

277 By confining base damage to the telomeres, we show that telomeric 8-oxoG a

278 l as protective mechanisms against oxidative damage to the termite gut and its microbiota.

279 ls, they tend to be bulky and stiff, causing damage to the tissue they are implanted in.

280 e failure of body organs and thereby causing damage to the tissues resulting in death of the neonates

281 Oxidative stress/damage to the trabecular meshwork in such post-vitrectom

282 Increasing damage to the tract connecting the stimulated right infe

283 mediates local cell injury, but also induces damage to the transplanted cells.

284 ust electrophysiology technique with minimal damage to the underlying tissue.

285 multiattribute objects in humans with focal damage to the VMF (N = 12) compared with a healthy group

286 However, damage to the Watson-Crick faces of nucleobases has been

287 commonly assumed that deleterious alkylation damage to the Watson-Crick faces of nucleobases predomin

288 th free radicals leads, among other types of damages, to the production of stable carbonyl groups, wh

289 r, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activ

290 enchymal stromal cells (MSC) undergo massive damage to their mitochondrial function after irradiation

291 o a spiral shape to prevent photoirradiation damage to their photosynthetic surfaces.

292 ial for performing daily life activities, as damage to these pathways can result in faulty movements.

293 Damage to this delicate layer can result in increased pr

294 ive way to foster DNA transaction-associated damages to trigger cell death in proliferating cancer ce

295 Damage to vagus nerves as well as evidence of esophagus

296 ts as a hemorrhagic fever that causes severe damage to visceral organs.

297 able tumor destruction without causing undue damage to vital healthy tissues.

298 d traumatic cataracts because it causes less damage to weakened zonules.

299 ning relies upon the parahippocampal cortex, damage to which renders patients unable to navigate thei

300 in imaging in patients with CKD has revealed damage to white matter in the prefrontal cortex and, in