ライフサイエンスコーパス: dampening of

1 s histones through two separable mechanisms: dampening of acetyl-coenzyme A-dependent carbon metaboli

2 ese mice, the D299A mutation caused a global dampening of Aire's transcriptional impact, resulting in

3 ex effects on cellular physiology, including dampening of an inflammatory innate immune pathway resul

4 A similar dampening of anergy occurred after depletion of perinata

5 cells in GBs is thought to contribute to the dampening of antitumor immunity.

6 Cs supported IL-10 production and subsequent dampening of antiviral T cell responses.

7 lecular mechanism by which they achieve this dampening of arrestin recruitment.

8 anti-B cell therapy may provide a temporary dampening of autoimmune processes through B cell depleti

9 d to reverse disease upon adjuvant-dependent dampening of autoimmunity.

10 sponsive reporter DR5::GUS suggests that the dampening of auxin responses in the stigma epidermis pro

11 Dampening of beta(2) -integrin function of eosinophils i

12 results appear to challenge the notion that dampening of betaAR signaling in the failing heart is pr

13 Our results suggest that selective epitope dampening of BG505 trimers by ICs is rather ineffective.

14 activation of GIRK channels, leading to the dampening of both spindle-like and epileptiform thalamic

15 encoded scavenger for calcium, we show that dampening of calcium signaling accelerates the accumulat

16 tic reversal of IgG1 to IgM, pharmacological dampening of calcium signaling, or treatment with interl

17 al changes were accompanied by a significant dampening of CD4(+) T cell polarisation.

18 egulatory T cells ("suppression") and direct dampening of CD4(+) T cell reactivity ("tuning").

19 tumor microenvironment including progressive dampening of CD8+ T cells and aberrant cell-to-cell comm

20 cellular redistribution resulted in a global dampening of cell responsiveness, as illustrated by redu

21 cation correlates temporally with the stable dampening of chemotaxis that is indicative of long-term

22 This interaction correlates with a dampening of cIAP1 to polyubiquitinate NEMO and to activ

23 tiation of the strongest sensory input and a dampening of cortical inhibition over the BLA, thus augm

24 el of PTGS2 transcription, consistent with a dampening of COX-2 expression in chronic periodontitis.

25 activation of AhR by dietary ligands in the dampening of cutaneous allergic responses and uncovers t

26 ection of amoebae, growth within lung cells, dampening of cytokines, and tissue destruction.

27 rily by increased cloud cover resulting in a dampening of daytime temperatures, over twice the area o

28 The resultant long-term dampening of dopamine neuron excitability may serve to t

29 mitant with effector binding nucleate global dampening of dynamics.

30 otic period of 4-5 years, with a progressive dampening of epizootic size and progressive decrease in

31 e between proinflammatory mechanisms and the dampening of excessive immune activation is critical for

32 ed a low ongoing firing rate, due in part to dampening of excitability by a tonic inhibitory conducta

33 ally important, as drug-mediated and genetic dampening of FA oxidation resulted in a selective reduct

34 Dampening of Fyn kinase activity also inhibited RhoA act

35 lved in bone formation through NMP4-mediated dampening of Gadd34 and c-Myc expression.

36 o methylated sites in the genome, leading to dampening of gene expression.

37 as global O-GlcNAcylation analysis indicates dampening of global O-GlcNAcylation rhythm in mice fed u

38 These effects range from dampening of glutamate release from excitatory terminals

39 diator of cardiovascular homeostasis through dampening of GPCR signaling, and is expressed in the hea

40 signaling pathway defined by NLRP12-mediated dampening of host immune defenses that could be exploite

41 in strains displaying enhanced virulence and dampening of host immune responses compared with their r

42 vious data indicate that UPEC promotes local dampening of host innate immune responses.

43 eported in this model, in conjunction with a dampening of host mononuclear cell responses, including

44 LRB1(5), which could potentially lead to the dampening of human immune responses.

45 by DC of IL-17A-inhibiting cytokines and the dampening of IL-1beta and IL-23.

46 Further studies of CCR5 antagonists in the dampening of immune activation associated with HIV infec

47 been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and t

48 in-2-producing CD4(+) cells, consistent with dampening of immune responses.

49 ling cascade, leading to macrophage skewing, dampening of inflammation, and regeneration of muscle fi

50 , homeostatic turnover, host defense, active dampening of inflammation, and tissue repair.

51 arance, inhibition of protease activity, and dampening of inflammatory cell recruitment.

52 Dampening of inflammatory cues through interleukin-1beta

53 ation, ranging from the amplification to the dampening of inherent behavioral differences in heteroge

54 the central sites, is required for the rapid dampening of initial responses.

55 rt that STAT3 plays a key role in amino acid dampening of insulin signaling in hepatic cells.

56 These findings suggest that a dampening of insulin-induced phosphorylation of AS160 on

57 ression under Th17-inducing conditions, with dampening of intracellular AKT phosphorylation.

58 d conformations was further confirmed by the dampening of its amplitude upon covalent substrate trapp

59 the capsid is elicited, as well as a general dampening of its breathing motions.

60 tion of FoxO3 from nucleus to cytoplasm with dampening of its transcriptional program, including anti

61 chanism is understood as the pressure-driven dampening of layer "rippling," which acts to increase th

62 expression of interleukin-10 and an eventual dampening of LPS-mediated cytokine production in macroph

63 Disruption of this normal homeostatic dampening of lung inflammation results in increased resi

64 Ultimately, a reduction in LC3 flux and dampening of macroautophagy are observed in dendritic ce

65 eal a novel mechanism in which IL-6-mediated dampening of macrophage activation protects tissues from

66 a7nAChR and is possibly mediated through the dampening of mast cells and increased phagocytosis of OV

67 diurnally oscillating light stimulus caused dampening of maximal Lhcb mRNA accumulation levels, with

68 ion to advanced fibrosis was associated with dampening of metabolic, oxidative stress and cell stress

69 tigative effects of this drug possibly via a dampening of metabolism-based tissue injury, thus aiding

70 bition of the dynein-NCAM180 interaction, or dampening of microtubule dynamics with low dose nocodazo

71 ZIKV-infected NSCs show global dampening of miRNA production, including key miRNAs link

72 reduction in systemic cytokine release with dampening of myocardial inflammation, injury, and apopto

73 uman immune adaptations to uG, including the dampening of Natural Killer, CD4(+) and CD8(+) T cell re

74 t firing rate activity, pacing, and critical dampening of neuronal circuits.

75 se behavioral effects were associated with a dampening of neuronal excitability in the basolateral am

76 ssential for the induction and developmental dampening of NMDAR-LTD.

77 This could be partly explained by dampening of oscillatory dynamics present during station

78 2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by in

79 is non-canonical RCOR1 activity is linked to dampening of POL-II productive elongation at actively tr

80 rectionally altered through amplification or dampening of post-trial activity decay through simulated

81 cytokines, including an early but transient dampening of pro-inflammatory cytokines (e.g., interleuk

82 wild-type bacterium was not attributable to dampening of pro-inflammatory responses by CbpD ex vivo

83 ects of isoflurane anesthesia and associated dampening of pro-inflammatory responses.

84 nuate autoimmunity likely occurs through the dampening of pro-inflammatory signals upon engulfment of

85 Augmentation or dampening of proinflammatory responses can be of value i

86 g an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of typ

87 Moreover, the magnitude of dampening of repressor dynamics tracks with the magnitud

88 Mechanical dampening of resonant oscillations due to the presence o

89 integrin and the insulin receptor leading to dampening of skeletal-muscle insulin receptor signaling.

90 neutralizing antibody titers without overall dampening of spike protein-directed immune responses, in

91 plasmid pXO1 and pathogenicity may require a dampening of sporulation regulation by mutational select

92 Further, our findings indicate that Mdm2 dampening of Sprouty4 is a prerequisite for maintaining

93 eparation and execution leads to a transient dampening of STN oscillations, hence facilitating moveme

94 cuate nucleus (ARC) neurons, in concert with dampening of suprachiasmatic nucleus (SCN) circadian rhy

95 t provide a homeostatic mechanism for global dampening of synaptic strength following heightened neur

96 le in signal transduction, viral resistance, dampening of systemic inflammatory cytokine production,

97 The dampening of T cell immunity was due to the defective pr

98 can exert regulatory function, including the dampening of T-cell activation, by interacting with the

99 tivation and a consequential DUSP4-dependent dampening of TCR signaling.

100 Time-dependent dampening of TH activity during the day reverses manic-r

101 f retinogeniculate synaptic transmission and dampening of thalamocortical output was mimicked by teta

102 ctivated factor VIII (FVIIIa) resulting in a dampening of the activity of the activated factor X-gene

103 effects were mediated, at least in part, by dampening of the antigen-specific immunosuppressive func

104 pathway in cardiac failure, contributing to dampening of the beta-adrenergic response.

105 facilitation of growth in epithelia, and the dampening of the chemokine and cytokine output from infe

106 correlation with pain affect may result from dampening of the effective connectivity of the midbrain-

107 the metabolic alterations, which resulted in dampening of the excessive cytokine production.

108 aS and forskolin), suggesting a compensatory dampening of the G protein-adenylyl cyclase system in th

109 Among cat owners, no such dampening of the genetic effect was observed.

110 hat CpG-induced immune regulation leads to a dampening of the host immune response and healing in the

111 injury-induced induction of HSP72; and that dampening of the HSP72/HSP25 response and ablation of th

112 ith containment of the organism and apparent dampening of the inflammation of host tissue.

113 Successful commensalism requires dampening of the inflammatory response and evasion of ho

114 activation secondary to loss of Cav1 signals dampening of the innate immune response to lipopolysacch

115 EB2A-dependent pathway and that constitutive dampening of the InsP(3) signal reveals unanticipated in

116 culogenic mimicry patterns is accompanied by dampening of the invasive and metastatic uveal melanoma

117 rker expression suggested an apparent global dampening of the neuroinflammatory response.

118 nic activation of one (PI3K/PKB) can lead to dampening of the other (ERK1/2), reducing the mitogenic

119 rmine that the force defect results from the dampening of the pulsatile recruitment of cell adhesion

120 tress in these areas, but there was a slight dampening of the response in ADX/B animals.

121 lmarks of inflammation resolution, including dampening of the T helper 1 response, alternative activa

122 ate production of IFN-gamma and a consequent dampening of the Th1 as well as the Th17 effector respon

123 rment in Foxp3 induction was part of a broad dampening of the typical T reg transcriptional signature

124 hat the rhythm can persist after substantial dampening of their activity.

125 targets within coding regions; however, the dampening of these effects by translation likely account

126 ence sCD14 and oxLDL and the extent to which dampening of these markers mediates CVD-protective effec

127 Dampening of TLR2 signaling does not require viable M. t

128 Dampening of TNF-RII or TNF-RI+RII leads to a stage-inde

129 The dampening of top-down control, and thus ecosystem regula

130 ng synaptogenesis, which enables coordinated dampening of transcortical developmental signals.SIGNIFI

131 ltration, downregulation of cilia genes, and dampening of type 2 inflammation.

132 n the group level, older adults show a broad dampening of uncertainty adjustment relative to younger

133 This lack of dampening of vibrational forces may partially explain wh

134 of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive

135 Continent-scale dampening of vole population cycles, keystone herbivores

136 spreads across the X chromosome and induces dampening of X-linked gene expression in naive hPSCs.