ライフサイエンスコーパス: de novo synthesis

1 erated either by salvage pathways or through de novo synthesis.

2 without significant enhancement of collagen de novo synthesis.

3 nzo-p-dioxins and dibenzofurans (PBDD/Fs) by de novo synthesis.

4 from the extracellular milieu as opposed to de novo synthesis.

5 1), the first and rate-limiting enzyme of FA de novo synthesis.

6 lk or between muscle and albumen, suggesting de novo synthesis.

7 idine, due to suppression of both uptake and de novo synthesis.

8 small and that sustained secretion requires de novo synthesis.

9 protein expression through inhibition of its de novo synthesis.

10 amino acid addition, suggesting a completely de novo synthesis.

11 ORMDL3 inhibits sphingolipid de novo synthesis.

12 filaments, suggesting a mechanism involving de novo synthesis.

13 nism of detoxification while attenuating its de novo synthesis.

14 owed an approximately 50% increase in serine de novo synthesis.

15 embranes, is generated by its remodeling and de novo synthesis.

16 ion channels, has been made possible through de novo synthesis.

17 alpha(1)-AR mediated IL-6 secretion through de novo synthesis.

18 -mediated endocytosis of lipoproteins or via de novo synthesis.

19 eviously unreported and inaccessible through de novo synthesis.

20 rous reports of elegant strategies for their de novo synthesis.

21 : bulk uptake from the cytoplasmic pool, and de novo synthesis.

22 ns, mobilization of intracellular lipid, and de novo synthesis.

23 r need for cholesterol through its uptake or de novo synthesis(1), but the extent to which cancer cel

24 The nature of the de novo synthesis also enables the preparation of both e

25 are the only cell type that must balance the de novo synthesis and absorption of cholesterol, althoug

26 arum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids.

27 ation, we conclude that only one pathway for de novo synthesis and attachment of lipoic acid exists i

28 Here we report the first de novo synthesis and cell-free cloning of custom DNA li

29 that the rise in PC resulted from increased de novo synthesis and correlated with an induction of ch

30 we showed that SR141716 induced cholesterol de novo synthesis and high-density lipoprotein uptake, r

31 and elicited a NALP3 activation, leading to de novo synthesis and inflammasome priming.

32 Improvements in de novo synthesis and intestinal absorption increase glu

33 lar DNA topoisomerases are required for both de novo synthesis and intracellular amplification of ccc

34 eded for steroidogenesis is provided by both de novo synthesis and isoprenylation-dependent mechanism

35 was no evidence of a difference in cysteine de novo synthesis and its total flux or erythrocyte glut

36 hould enable broad synthetic applications in de novo synthesis and late-stage functionalization chemi

37 ows for integrated, physiological studies of de novo synthesis and metabolism and transport of materi

38 that demands much lower energetic cost than de novo synthesis and reassembly of the entire CI.

39 The cysteine flux, its de novo synthesis and release from protein breakdown, an

40 biosynthetic pathway, the purine, pyrimidine de novo synthesis and salvage and interconversion routes

41 African trypanosomes are capable of both de novo synthesis and salvage of pyrimidines.

42 iliary atresia through a unique mechanism of de novo synthesis and secretion of bile salts in intesti

43 of preformed inflammatory mediators and the de novo synthesis and secretion of cytokines and chemoki

44 ted in different domains as a result of both de novo synthesis and transport.

45 H. halophila performs both de novo synthesis and uptake of glycine betaine, matchin

46 correspond to fatty acid uptake from media, de novo synthesis, and elongation.

47 mM through a combination of dietary uptake, de novo synthesis, and muscle protein catabolism.

48 de-off between host nucleotide recycling and de novo synthesis, and that photoperiod and photon flux

49 possible CCR5 degradation with a subsequent de novo synthesis, and that re-expression of CCR5 on the

50 The last two steps in de novo synthesis are catalysed by UMP synthase (UMPS) -

51 Collagen breakdown and de novo synthesis are important processes during early w

52 nd in pharmaceutical substances; this leaves de novo synthesis as the principal strategy for preparat

53 role in all three routes of NAD biogenesis, de novo synthesis as well as the two salvage pathways.

54 ty by upregulation of B1R expression through de novo synthesis, as well as rapid translocation of pre

55 ogy-mediated end joining (SD-MMEJ), in which de novo synthesis by an accurate non-processive DNA poly

56 obalamin in the surface ocean is a result of de novo synthesis by heterotrophic bacteria or via modif

57 nd calculated indexes of FA desaturation and de novo synthesis by the mammary gland.

58 ion caused TRAIL secretion in the absence of de novo synthesis by triggering release of prefabricated

59 ut in the absence of preexisting centrioles, de novo synthesis can occur.

60 In addition to de novo synthesis, cells recycle nucleotides from the DN

61 c In-vitro Cloning (MIC) and applied them to de novo synthesis, combinatorial assembly and cell-free

62 This de novo synthesis creates opportunities for the preparat

63 ased ceramide levels reflected their reduced de novo synthesis, due to inhibition of the activity of

64 fatty acid accrual by uptake from plasma and de novo synthesis exceed elimination by mitochondrial ox

65 uptake because, unlike in plants, nucleotide de novo synthesis exclusively occurs in the cytosol.

66 rious sources, both exogenously supplied FA, de novo synthesised FA, or FA derived from lipolysis, to

67 e functionality of HCMV virions; rather, its de novo synthesis facilitates viral DNA synthesis, which

68 t the UVR8 dimer is not regenerated by rapid de novo synthesis following destruction of the monomer.

69 adrenal precursor steroids or possibly from de novo synthesis from cholesterol commonly requires enz

70 Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provide

71 In the second phase, de novo synthesis generates ceramide that reduces the ce

72 ial RNA polymerases that perform the initial de novo synthesis, generating the first 8-10 nucleotides

73 t is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required B

74 A de novo synthesis has been employed to prepare bacterioc

75 hich increases protein concentration without de novo synthesis; (ii) reduced protein degradation rate

76 intestinal cholesterol absorption as well as de novo synthesis in gallstone patients stratified accor

77 Here, through reconstitution of de novo synthesis in human cells, we surprisingly found

78 are obtained from the diet and generated by de novo synthesis in mammalian tissues.

79 ood sphingolipids, and assessed sphingolipid de novo synthesis in peripheral blood cells by measuring

80 y the energy demand of amino acid and enzyme de novo synthesis in photoautotrophic growth conditions.

81 s due to trafficking from megakaryocytes and de novo synthesis in platelets and is associated with in

82 sex dependent, but also that there is little de novo synthesis in the testis.

83 De novo synthesis in vivo requires an endogenous accepto

84 atic steatosis in alcohol-fed mice, but only de novo synthesis inhibition, not sphingomyelin hydrolys

85 Nucleotide de novo synthesis is highly conserved among organisms an

86 ene invalidations in single hepatocytes, Epo de novo synthesis led to its secretion, to splenic eryth

87 t differences in obese mice lacking ceramide de novo synthesis machinery in macrophages.

88 T cells in 3 of 4 patients who utilized the de novo synthesis mode and in 6 of 13 patients who perfo

89 itochondrial synthesis of acetyl-CoA, as the de novo synthesis of (13)C-labeled palmitate was increas

90 line required several hours, indicating that de novo synthesis of 18S was necessary.

91 d has been dissected into three major steps: de novo synthesis of a [2Fe-2S] cluster on a scaffold pr

92 ribution of energy resources only increasing de novo synthesis of a few key proteins.

93 s 25-hydroxyvitamin D 1alpha-hydroxylase for de novo synthesis of a focally high 1,25-dihydroxyvitami

94 in porous materials circumvents the need for de novo synthesis of a metal-organic framework, making i

95 capsid protein from 1 to 72 h and increasing de novo synthesis of a previously unidentified 17-kDa pr

96 An enantioselective de novo synthesis of a thioglycoside derivative of the 6

97 of Phex in UMR106 cells and did not require de novo synthesis of a transrepressor.

98 malian codons (codon deoptimization) for the de novo synthesis of a viral NS RNA segment based on inf

99 in isolated functional nuclei decreased the de novo synthesis of acetyl-CoA and acetylation of core

100 ransferase (EC 3.1.3.73) and is required for de novo synthesis of AdoCbl (coenzyme B(12)).

101 (PMo) required activation of TLR4 to induce de novo synthesis of alphavbeta3 enabling WISP1 to stimu

102 e has been hypothesized to include increased de novo synthesis of amino acid neurotransmitters, espec

103 nction in one-carbon metabolism to allow the de novo synthesis of amino acids and nucleosides.

104 f carbon and energy, it is not known whether de novo synthesis of amino acids by intravacuolar L. pne

105 adenylosuccinate to AMP, which occurs in the de novo synthesis of AMP and also in the purine nucleoti

106 ADSL executes two nonsequential steps in the de novo synthesis of AMP: the conversion of phosphoribos

107 De novo synthesis of an inhibitory transcription factor

108 Glutamine is the ultimate source for de novo synthesis of arginine in humans via the intestin

109 establish the contribution of the kidneys to de novo synthesis of arginine in patients receiving intr

110 whole-body citrulline turnover was used for de novo synthesis of arginine.

111 Challenges to the de novo synthesis of bacteriochlorophyll a (BChl a), the

112 tional integral membrane proteins during the de novo synthesis of biomimetic phospholipid bilayers is

113 ts recent impressive progress in the area of de novo synthesis of carbohydrates by using organocataly

114 ACSL1 prevented de novo synthesis of cardiotoxic C16- and C24-, and C24:

115 or CD4(+) T cells and APCs are too short for de novo synthesis of CD40L.

116 tirely elucidated, we have hypothesized that de novo synthesis of ceramide, through the rate-limiting

117 Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates C

118 depletion induces the UPR by increasing the de novo synthesis of ceramide.

119 g DRMs by lowering cholesterol or inhibiting de novo synthesis of ceramides at the ER largely decreas

120 se model (Dhcr7(-/-)), which is incapable of de novo synthesis of cholesterol, in utero treatment wit

121 terica is an l-threonine kinase used for the de novo synthesis of coenzyme B(12) and the assimilation

122 Npr1-phosphorylated Orm1 and Orm2 stimulate de novo synthesis of complex sphingolipids downstream of

123 sses all steroidogenic enzymes necessary for de novo synthesis of corticosterone from cholesterol, fu

124 miR-503 precursor (pre-miR-503) reduced the de novo synthesis of CUGBP1 protein, whereas inhibiting

125 ns of multiple phagosomal TLRs, resulting in de novo synthesis of Cxcl2, amplification of neutrophil

126 The de novo synthesis of cysteinyl leukotrienes, TNFalpha, C

127 egulation of three of the LHCX genes and the de novo synthesis of Dd+Dt led to a pronounced rise of q

128 aled the participation of this enzyme in the de novo synthesis of defensive monoterpenoids in the bee

129 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (d

130 se (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleotide triphosphates (

131 eductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (

132 uctases (RNRs) catalyze the only pathway for de novo synthesis of deoxyribonucleotides needed for DNA

133 spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however,

134 ly, lapatinib and palbociclib strictly block de novo synthesis of DNA, mostly through disruption of E

135 aring drugs in mouse tissues and visualizing de novo synthesis of DNA, RNA, proteins, phospholipids a

136 ere we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on re

137 ibonucleotide reductase, responsible for the de novo synthesis of dNTPs, is a cytosolic enzyme maxima

138 Inhibition of de novo synthesis of Drosha and Dicer in the embryo led

139 c pathways, including those required for the de novo synthesis of dTMP and purine nucleotides and for

140 es present in the decidual tissue to support de novo synthesis of E.

141 p to 3 m NaCl in a minimal medium due to the de novo synthesis of ectoines.

142 (6)A levels of cellular RNA, suggesting that de novo synthesis of Env is not required for m(6)A up-re

143 in cargo concentration acts as a trigger for de novo synthesis of ERES.

144 revealed that, following embryo attachment, de novo synthesis of estrogen by the decidual cells is c

145 s served an essential role in supporting the de novo synthesis of fatty acids for the expansion of th

146 ciency leads to a decrease in glycolysis and de novo synthesis of fatty acids in hepatocytes.

147 The first and rate-limiting reaction in de novo synthesis of fatty acids is carboxylation of ace

148 of human prostate cancer exhibits increased de novo synthesis of fatty acids, but the molecular driv

149 nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation an

150 cell is dependent on both salvage as well as de novo synthesis of fatty acids.

151 e) catalyzes the first committed step in the de novo synthesis of fatty acids.

152 the first and rate-limiting reaction in the de novo synthesis of fatty acids.

153 ions suggestive of enhanced capacity for the de novo synthesis of fatty acids.

154 CoA, the first and rate-limiting reaction in de novo synthesis of fatty acids.

155 t p120-catenin in LPP3-depleted ECs restored de novo synthesis of fibronectin, which mediated EC migr

156 hellem, but in E. romaleae those involved in de novo synthesis of folate are all pseudogenes.

157 synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated i

158 A divergent, practical, and efficient de novo synthesis of fully functionalized L-colitose (3,

159 iological components has been facilitated by de novo synthesis of gene-length DNA.

160 ompounds require accurate and cost-effective de novo synthesis of genetic pathways.

161 trate that CPT1C is directly involved in the de novo synthesis of GluA1 and not in protein degradatio

162 ediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on

163 he Krebs cycle, was shown to be required for de novo synthesis of glutamate and glutamine in Listeria

164 e/cysteine transporter EAAC1 is required for de novo synthesis of glutathione in neurons.

165 PEP) generated from pyruvate is required for de novo synthesis of glycerol and glycogen in skeletal m

166 IMP dehydrogenase, a rate-limiting enzyme in de novo synthesis of guanidine nucleotides.

167 PDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the

168 BACKGROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose,

169 De novo synthesis of guanosine diphosphate (GDP)-fucose,

170 onical NF-kappaB and involves the sequential de novo synthesis of IFN regulatory factor (IRF)1 and Vi

171 t TGF-beta led to enhanced transcription and de novo synthesis of IL-6 upon activation without affect

172 noimidazole carboxamide, which occurs in the de novo synthesis of IMP, and the conversion of adenylos

173 ost saturated fatty acids to be used for the de novo synthesis of its membrane constituents.

174 amines as efficient organocatalysts for the de novo synthesis of ketoses and deoxyketoses.

175 During subsequent dark or shade recovery, de novo synthesis of L and Z continued, followed by epox

176 nhibition of astrocytic Phgdh suppressed the de novo synthesis of l-and d-serine and reduced the NMDA

177 The highly stereocontrolled de novo synthesis of l-NBDNJ (the unnatural enantiomer o

178 PDGFRalpha has been reported to induce de novo synthesis of LAMB1 protein in a Sjogren syndrome

179 ssed including the tantalizing vision of the de novo synthesis of life and the idea of self-synthesis

180 reactions can be harnessed to achieve facile de novo synthesis of lipid membranes, and spontaneous me

181 id biosynthesis and is rate-limiting for the de novo synthesis of lipids.

182 t on the level of phosphatidate used for the de novo synthesis of membrane phospholipids.

183 this recycling pathway is F-actin dependent, de novo synthesis of micronemes appears to be F-actin in

184 Solvent assisted linker exchange (SALE) and de novo synthesis of mixed-linker ZIFs have been demonst

185 Unfortunately, de novo synthesis of MOFs with desirable function-proper

186 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from sa

187 Because the de novo synthesis of multiple glutamine-derived anabolic

188 function mutations in genes required for the de novo synthesis of NAD were previously identified in i

189 xpression of BNA2, which is required for the de novo synthesis of NAD(+).

190 nolinate Synthase (QS) gene required for the de novo synthesis of NAD.

191 -dependent type I PA phosphatase involved in de novo synthesis of neutral lipids and phospholipids.

192 of intact PAR(2) from the Golgi apparatus or de novo synthesis of new receptors by incompletely under

193 notransferase pathways and redirected to the de novo synthesis of nitrogen assimilation machinery, si

194 ses had previously been shown to promote the de novo synthesis of nucleotide precursors, as well as t

195 irst members of the family in the 1990s, the de novo synthesis of only a single polycyclic furanobute

196 talyst constitute two parallel routes to the de novo synthesis of orthogonally protected biologically

197 tilization of trehalose as an energy source, de novo synthesis of other stress effectors, or the meta

198 Suppression of the de novo synthesis of PA resulted in G1 cell cycle arrest

199 to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membra

200 s dependent upon the enzymes responsible for de novo synthesis of PA.

201 acid synthase (FASN) is responsible for the de novo synthesis of palmitate.

202 In plants, de novo synthesis of pCho relies on the phosphobase meth

203 Once at this new site, PBP2x catalyses the de novo synthesis of peptidoglycan, which is imaged by t

204 may be exocytosed by neurons during OGD and de novo synthesis of perlecan is increased during reperf

205 A new general de novo synthesis of pharmaceutically important N-(heter

206 We found that genetic inactivation of de novo synthesis of phosphatidylethanolamine (PE) mitig

207 hosphatidic acid phosphatase involved in the de novo synthesis of phospholipids and triglycerides.

208 osphatidic acid phosphatases involved in the de novo synthesis of phospholipids and triglycerides.

209 s on phytol derived from chlorophyll, not on de novo synthesis of phytyl-diphosphate from geranylgera

210 We conclude that de novo synthesis of polyamines during adipogenesis is r

211 ating E3 ubiquitin ligase that initiates the de novo synthesis of polyubiquitin chains that are attac

212 Thus, de novo synthesis of precursors for the protein lipoylat

213 ept that glycerophosphoinositol inhibits the de novo synthesis of proinflammatory and prothrombotic c

214 n, the transcription factor Nrf1 facilitates de novo synthesis of proteasomes by inducing proteasome

215 e thought to be solidified (consolidated) by de novo synthesis of proteins in the period subsequent t

216 ion mechanism of PSII is associated with the de novo synthesis of proteins.

217 tion that can result in increased demand for de novo synthesis of purine and pyrimidine bases require

218 ylori has lost several genes involved in the de novo synthesis of purine nucleotides, and without thi

219 The de novo synthesis of purine precursors is under tight ne

220 ed genome and lacks the enzymes required for de novo synthesis of purines for synthesis of RNA and DN

221 to carry and activate single carbons for the de novo synthesis of purines, thymidylate, and for the r

222 ed one-carbon metabolism is required for the de novo synthesis of purines, thymidylate, and S-adenosy

223 ivergently from pdxR and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the m

224 In plants, the pathway for de novo synthesis of pyridoxal phosphate has been well c

225 sential vitamins and cofactors and decreased de novo synthesis of pyrimidines in cycle two.

226 on of dihydroorotate (DHO) to orotate in the de novo synthesis of pyrimidines.

227 i appears to lack the metabolic capacity for de novo synthesis of riboflavin and so likely relies on

228 reducing power from the Calvin cycle to the de novo synthesis of saturated fatty acids to replace po

229 Through de novo synthesis of sceptrin and massadine, we show tha

230 These vDNAs template de novo synthesis of secondary viral siRNAs (vsRNA), whi

231 arry out the specialized function of halting de novo synthesis of several abundant porins when envelo

232 We stimulated de novo synthesis of SNAT2 mRNA and increased SNAT2 mRNA

233 herosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine p

234 The results showed that inhibition of de novo synthesis of sphingolipids, pharmacologically or

235 NKPD1 is predicted to be involved in the de novo synthesis of sphingolipids, which have been impl

236 Human chorionic gonadotropin (hCG) induces de novo synthesis of STAR, a process shown to parallel m

237 A de novo synthesis of substituted pyridines is described

238 such as histamine and proteases, and in the de novo synthesis of sulfidoleukotrienes.

239 We describe a one-pot de novo synthesis of sulfonimidamides from widely availa

240 pids to TAG but being impaired in additional de novo synthesis of TAG during -N stress.

241 her hand, DGAT2 seemed to be specialised for de novo synthesis of TAG from glycerol-3-posphate only.

242 o generate TAG, as well as being involved in de novo synthesis of TAG.

243 t activity without affecting the LPS-induced de novo synthesis of TF protein.

244 yeast, PLMT activities are required for the de novo synthesis of the choline headgroup found in PtdC

245 , which functions in the visual cycle and in de novo synthesis of the chromophore.

246 FASN is responsible for de novo synthesis of the fatty acid palmitate; the build

247 ZmPep1 activates de novo synthesis of the hormones jasmonic acid and ethy

248 Importantly, doxorubicin also increased de novo synthesis of the pro-apoptotic sphingolipid meta

249 diated via ceramide synthase (CS)-stimulated de novo synthesis of the proapoptotic sphingolipid ceram

250 ellular dihydroceramides, sphingoid bases in de novo synthesis of the sphingolipid pathway.

251 De novo synthesis of the sphingolipid sphingomyelin requ

252 tionally active and we demonstrate the novel de novo synthesis of the triamine spermidine from the di

253 fractions, respectively, indicating partial de novo synthesis of these amino acids by L. pneumophila

254 nate and that Histoplasma virulence requires de novo synthesis of these cofactor precursors.

255 r cyclin B1 destruction because of regulated de novo synthesis of this cyclin after prometaphase onse

256 o the microRNA 29a promoter, thus inducing a de novo synthesis of this miRNA.

257 se subunit 1 declined concomitantly with the de novo synthesis of this subunit whereas polyadenylatio

258 rconnected pathways that is required for the de novo synthesis of three of the four DNA bases and the

259 Here, we describe the de novo synthesis of three paralytic shellfish poisons,

260 De novo synthesis of threonine from aspartate occurs via

261 Neurons are considered incapable of de novo synthesis of tricarboxylic acid cycle intermedia

262 c pathway requires glucose and glutamine for de novo synthesis of UDP-GlcNAc, a sugar-nucleotide that

263 implications are discussed, suggesting that de novo synthesis of urease under anoxic conditions is n

264 promotes cellular adaptation, including the de novo synthesis of vacuolar hydrolases to boost the va

265 s, indicating that MDMs are able to initiate de novo synthesis of viral DNA and promote virus release

266 t the internalization of virus could lead to de novo synthesis of viral protein from incoming viral R

267 Rates of de novo synthesis of viral proteins in wild-type and SGM

268 ion of integrin alpha4beta7 was dependent on de novo synthesis of viral proteins, but neither cell de

269 e ability to eliminate infected cells before de novo synthesis of viral proteins, which was also obse

270 ) the increase of viral RNAs along time; (3) de novo synthesis of viral proteins; and (4) secretion o

271 While these events that occur prior to the de novo synthesis of viral RNA are required for the indu

272 olution, we describe a low-cost, easy-to-use de novo synthesis oligonucleotide microarray technology

273 rocess in every organism, is accomplished by de novo synthesis or by salvaging pyrimdines from e.g. n

274 rhGH increased glutamine de novo synthesis (P < 0.02) and plasma concentrations (

275 hosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cel

276 Enzymes of the folate de novo synthesis pathway in malaria parasites are prove

277 s two fatty acid synthesis pathways: a major de novo synthesis pathway in the ER and a mitochondrial

278 mutations in KDSR, encoding an enzyme in the de novo synthesis pathway of ceramides.

279 2 and 3) mediate feedback inhibition of the de novo synthesis pathway of sphingolipids by inhibiting

280 es from two sources: a salvage pathway and a de novo synthesis pathway that depends on two enzymes, t

281 phingomyelinase pathway rather than ceramide de novo synthesis pathway was important for inflammatory

282 the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway.

283 e incorporation into RNA and DNA through the de novo synthesis pathway.

284 disclosing the last missing enzyme of the SL de novo synthesis pathway.

285 ssential enzyme common to both recycling and de novo synthesis pathways, displayed the same bacterici

286 ive, and (iv) HIV-1 ligands are derived from de novo synthesis rather than endocytic sampling.

287 t at the plasma membrane was slow, requiring de novo synthesis, rather than recycling.

288 te PKD in the Golgi; PAR(2) mobilization and de novo synthesis repopulate the cell surface with intac

289 While many bacteria are capable of Q de novo synthesis, salvage of the prokaryotic Q precurso

290 cation is a complex process composed of many de novo synthesis steps catalyzed by a myriad of molecul

291 haride in the absence of exogenous acceptor (de novo synthesis) than PmHS1.

292 In comparison to de novo synthesis, this metal-induced topological transf

293 biosynthesis, demonstrating contribution of de novo synthesis to NAD(+) homeostasis.

294 fer that peroxisome biogenesis switches from de novo synthesis to primarily fission.

295 Surprisingly, inhibition of de novo synthesis using myriocin or fumonisin B1 resulte

296 Notably, inhibition of de novo synthesis was associated with potentiation of AD

297 In contrast, inhibition of de novo synthesis was linked to decreased expression of

298 es despite the absence of other genes of NAD de novo synthesis, was elucidated.

299 when produced by pathways other than that of de novo synthesis, we examined primary mouse hepatocytes

300 ve gene machinery for pyrimidine salvage and de novo synthesis, we inferred genealogies for each enzy