ライフサイエンスコーパス: deacetylate

1 step of enzymatic deproteinization and after deacetylated.

2 D, superoxide dismutase, and PEPCK1 were not deacetylated.

3 egatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

4 RT1 physically associates with DNMT1 and can deacetylate acetylated DNMT1 in vitro and in vivo.

5 The Escherichia coli deacetylase CobB could deacetylate acetylated MDH, while the E. coli acetyltran

6 de of galactose and GalNAc that is partially deacetylated after secretion.

7 Although SIRT1 deacetylates Akt to promote phosphatidylinositol (3,4,5)

8 dependent deacetylases because cells fail to deacetylate alpha-tubulin-K40 and histone H3-K9.

9 is a class IIb deacetylase that specifically deacetylates alpha-tubulin, modulates microtubule dynami

10 Though HDAC6 deacetylates alpha-tubulin, we find that another HDAC6 s

11 zyme HDAC6 regulates microtubule function by deacetylating alpha-tubulin, which suppresses microtubul

12 keletal muscle, primarily via its ability to deacetylate and activate peroxisome proliferator-activat

13 xl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl

14 ced to a reduced effect of Sirt1 to directly deacetylate and repress IRS-1 function.

15 SIRT3 deacetylated and activated GSK3beta and thereby blocked

16 In response to cAMP signaling, SIRT3 deacetylated and activated leucine-rich protein 130 (LRP

17 oactivator 1-alpha (PGC1alpha), which became deacetylated and hyperactive after oleic acid treatment.

18 edia, whereas lipids that pass the cycle are deacetylated and retained within the cell.

19 The latter was sequentially deacetylated and selectively benzylated to give 8-azido-

20 Nakagawa et al. show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carba

21 restriction, mitochondrial deacetylase Sirt3 deacetylates and activates IDH2, thereby regulating the

22 SIRT3 deacetylates and activates LKB1, thus augmenting the act

23 In response to CR, Sirt3 directly deacetylates and activates mitochondrial isocitrate dehy

24 transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha.

25 We show that under normal conditions, Sirt1 deacetylates and activates TORC1 by promoting its dephos

26 SIRT1 deacetylates and coactivates the retinoic acid receptor

27 y, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY.

28 ediated SIRT3 phosphorylation, which in turn deacetylates and dimerizes CPT2 to enhance fatty acid ox

29 SIRT4 deacetylates and inhibits malonyl CoA decarboxylase (MCD

30 tylation-defective mutants showed that SIRT1 deacetylates and inhibits SREBP-1c transactivation by de

31 Sirtuin 3 (SIRT3) deacetylates and regulates many mitochondrial proteins t

32 ual complex made up of SIRT1 and HDAC4 which deacetylates and thereby favors SUMOylation of HIC1 by a

33 t histone deacetylase 6 (HDAC6) sequentially deacetylates and ubiquitinates MSH2, leading to MSH2 deg

34 nd controls reactive oxygen species (ROS) by deacetylating and activating isocitrate dehydrogenase 2

35 ny proteins, but whether SIRT1 has a role in deacetylating and altering the function of SIRT3 is unkn

36 etic repressor and its associated HDAC1 from deacetylating and suppressing E2F1.

37 eleting the genes required to phosphorylate, deacetylate, and deaminate GlcNAc to convert it to fruct

38 Here we demonstrate that SIRT2 binds, deacetylates, and inhibits the peroxidase activity of th

39 Sirtuin 1 (SIRT1) binds, deacetylates, and thereby inactivates HIF-1alpha.

40 cetylation while bound to chromosomes but is deacetylated as soon as it dissociates from chromosomes

41 HDAC3, by deacetylating aspirin-acetylated eNOS, antagonizes aspir

42 HDAC9 deacetylates ATDC, alters the ability of ATDC to associa

43 (HDAC6), which destabilizes microtubules by deacetylating beta-tubulin, protected both the microtubu

44 Moreover, MTA1 deacetylates BMAL1 at lysine 538 through regulating deac

45 d SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 1029 and 1033, stim

46 Acetylated SacAcsA was deacetylated by a sirtuin-type NAD(+)-dependent consumin

47 Acetylated SlAacS was deacetylated by a sirtuin-type protein deacetylase.

48 Alternatively, NA-DCVC can be deacetylated by aminoacylase 3 (AA3), an enzyme that is

49 In addition, each Htz1 N-terminal lysine is deacetylated by Hda1 in response to benomyl and reacetyl

50 Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11.

51 regulated through lysine acetylation and was deacetylated by HDAC6.

52 Following anaphase, ac-SMC3 is deacetylated by HDAC8.

53 As pH(i) decreases, histones are globally deacetylated by histone deacetylases (HDACs), and the re

54 tylated under high glucose conditions and is deacetylated by Sirt1 on lysine 81.

55 elated nuclear, p53, and Hsp10 were robustly deacetylated by Sirt1-3.

56 nscription factor-1a and beta-catenin can be deacetylated by Sirt1.

57 RRM2 is directly acetylated by KAT7, and deacetylated by Sirt2, respectively.

58 nt to Lys-318/Lys-322, were also efficiently deacetylated by SIRT3 following chemical acetylation.

59 lysines 6 and 10 and that these residues are deacetylated by sirtuin 2.

60 n this work, and two were acetylated but not deacetylated by sirtuin.

61 by the acetyltransferase p300 at Lys-566 and deacetylated by sirtuin1 (SIRT1).

62 ass spectrometry (MS) to identify substrates deacetylated by sirtuins.

63 L. monocytogenes peptidoglycan is deacetylated by the action of N-acetylglucosamine deacet

64 AT1 is acetylated by p300/CBP in situ and is deacetylated by the sirtuins SIRT1 and 2.

65 is acetylated during hypoxia but is rapidly deacetylated by the stress-responsive deacetylase Sirtui

66 We found that alpha-ADABA is then deacetylated by the zinc-dependent EutE monomer into dia

67 ished.Furthermore, Sirt1 interacted with and deacetylated c-Jun, yielding an inactive AP-1 factor.

68 Furthermore, SIRT1 directly bound to and deacetylated c-MYC.

69 We further showed that SIRT1 deacetylates c-Jun and that the cAMP pathway participate

70 However, SIRT1 interacts with and deacetylates c-Myc, resulting in decreased c-Myc stabili

71 SIRT2 interacts with and deacetylates CDK9 at lysine 48 in response to replicatio

72 chemical assays confirm DslA specificity for deacetylated cell wall, and usage of two glutamate resid

73 ds (LCBs; 40 to 70 mum) but not by chitosan (deacetylated chitin) microparticles, oligosaccharide chi

74 ely little is known about enzymes capable of deacetylating chitin.

75 ires all three Sir proteins, even with fully deacetylated chromatin, and involves the specific associ

76 ts and show that the SIR complex efficiently deacetylates chromatin templates and promotes the assemb

77 The current view is that they function by deacetylating chromatin, thereby limiting accessibility

78 Importantly, HDAC6 deacetylates CIDEC, leading to destabilization and reduc

79 icute Roseburia intestinalis, which together deacetylate complex galactoglucomannan (GGM).

80 This is due to Dyn2's interactions with deacetylated cortactin and downstream effectors, which c

81 SIRT5 deacetylates CPS1 and upregulates its activity.

82 SIRT1 interacts with and deacetylates CRABPII, regulating its subcellular localiz

83 This is rescued by forced expression of a deacetylated CTTN mimetic.

84 tylase 3 (HDAC3) directly interacts with and deacetylates cyclin A.

85 We found that SIRT2 deacetylates cyclin-dependent kinase 9 (CDK9) in a type

86 (HDAC) 6 exists exclusively in cytoplasm and deacetylates cytoplasmic proteins such as alpha-tubulin.

87 the sequence of beta-1,4-linked glucosamine (deacetylated/D) and N-acetylglucosamine (acetylated/A) u

88 SIRT1 was found to deacetylate Dcoh2, promoting its interaction with HNF-1a

89 SIRT6 deacetylated DDB2 at two lysine residues, K35 and K77, u

90 l, we demonstrate that SIRT6 promotes NER by deacetylating DDB2, thereby preventing the onset of mela

91 unological properties of both chitin and its deacetylated derivative chitosan are of relevance becaus

92 Chitosan, the deacetylated derivative of chitin, can be found in the c

93 hock promoter Hsp70 by maintaining HSF1 in a deacetylated, DNA-binding competent state.

94 , correlating with active transcription, but deacetylated during EMT, reflecting the repressive state

95 2015) describe a nuclear pool of LC3 that is deacetylated during starvation, leading to redistributio

96 EF1A1, whereas the histone deacetylase HDAC2 deacetylates eEF1A1.

97 thetases identified by this work, and RpLdaA deacetylated eight of them.

98 naturally modified cATPase with the in vitro deacetylated enzyme revealed a major conformational chan

99 asticity mediated by histone acetylating and deacetylating enzymes may contribute to addiction-like b

100 or depletion of HDAC6, suggesting that HDAC6 deacetylates ERK1/2.

101 ity of SIRT1 was required and PGC-1alpha was deacetylated following addition of T(3).

102 YATL2, indicating that Lys-19 requires to be deacetylated for full activity.

103 mation regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repres

104 reserving renal Sirt1 expression, the latter deacetylating forkhead box O3a (FOXO3a), inducing Bnip 3

105 We produced MOF protein in the deacetylated form by using a nonspecific lysine deacetyl

106 Chitosan, a deacetylated form of chitin, is a dietary fibre known fo

107 stead exposing chitosan, the partly or fully deacetylated form of chitin.

108 aled a 10-fold higher contamination with its deacetylated form, named NX-3, (up to 540 mg kg(-1) ) co

109 SIRT1 and SIRT2 deacetylate FOXO factors to regulate FOXO function.

110 However, how deacetylated FoxO exert their actions remains unclear.

111 ice homozygous for knock-in alleles encoding deacetylated FoxO1 (6KR).

112 knock-in of alleles encoding constitutively deacetylated FoxO1 in mice (Foxo1(KR/KR)) improves hepat

113 The data support the notion that deacetylated FoxO1 protects beta-cell function by limiti

114 SIRT1 deacetylates FoxO1 and enables activation of FoxO1 trans

115 totranscription through interacting with and deacetylating FoxO1.

116 rtuins 1 and 7 (SIRT1 and SIRT7) are able to deacetylate FOXO3 in vitro and in vivo, and that lipopol

117 0 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but

118 ligase subunit Skp2 binds preferentially to deacetylated FOXO3.

119 We demonstrate that SIRT2 deacetylates Foxo3a, activates Bim, and induces apoptosi

120 We show here that SIRT2 deacetylates Foxo3a, increases RNA and protein levels of

121 Here, we show that Agd3 deacetylates GAG in a metal-dependent manner, and is the

122 Polyclonal animal antibody raised to deacetylated glycoforms of PNAG and a fully human IgG1 m

123 clonal antibody that both bind to native and deacetylated glycoforms of PNAG mediated complement-depe

124 We suggest that Sir2 deacetylates H3K14 to target Clr4 to centromeres.

125 of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repres

126 as Drosophila Sir2 and human SIRT1 and SIRT2 deacetylate H3K56ac.

127 By binding to their promoters and deacetylating H3K9 at these sites, SIRT6 downregulates t

128 Sir2 also deacetylates H3K9Ac and H3K14Ac.

129 epistatic to sas2 deletion, indicating that deacetylated H4K16 mediates the delay caused by sas2 del

130 16 to arginine, which mimics constitutively deacetylated H4K16, delayed senescence and was epistatic

131 volves the specific association of Sir3 with deacetylated H4K16.

132 Sir2 preferentially deacetylates H4K16Ac and H3K4Ac, but mutation of these r

133 We found that SIRT1 deacetylated HDAC1 and stimulated its enzymatic activity

134 Inactive SaAcs(Ac) was deacetylated (hence reactivated) by the NAD(+) -dependen

135 f Molecular Cell, Lim et al. show that SIRT1 deacetylates HIF-1alpha and regulates its ability to res

136 Histone deacetylases (HDACs) that deacetylate histone and nonhistone proteins play crucial

137 the E-cadherin proximal promoter by ZEB1 to deacetylate histone H3 and to reduce binding of RNA poly

138 Sir3 binds to nucleosomes containing deacetylated histone H4 lysine 16 (H4K16) and, with Sir4

139 RT1) is a class III histone deacetylase that deacetylates histone and nonhistone proteins to regulate

140 oximal promoter region of the Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby sup

141 Intriguingly, Sir2 preferentially deacetylates histone H3 lysine 79 as compared to Hst2.

142 nteracts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB tar

143 hanistically, SIRT6 interacts with c-JUN and deacetylates histone H3 lysine 9 (H3K9) at the promoter

144 pon infection translocate to the nucleus and deacetylates histone H3K18, thus modulating the host tra

145 hromatin remodeler SNF2H to DSBs and focally deacetylates histone H3K56.

146 Throughout the macrophage genome, HDAC3 deacetylates histone tails at regulatory regions, leadin

147 -related genes by interacting with c-Jun and deacetylating histone 3 at Lys9 (H3K9).

148 inhibits Notch1 and Notch4 transcription by deacetylating histone H3K9.

149 modulates numerous functions in the cell by deacetylating histone lysine residues.

150 known as transcription corepressors through deacetylating histone tails.

151 in protein 1 (HP1)-containing complexes that deacetylate histones and methylate cytosine bases in DNA

152 er, localizing the Hos2 and Hst1 subunits to deacetylate histones in 5' transcribed regions.

153 Surprisingly, Hdac6 does not appear to deacetylate histones, but rather is required for Tip60-p

154 g mark and accordingly recruits enzymes that deacetylate histones.

155 t to formation of condensed structures, with deacetylated histones giving rise to highly compacted ch

156 a repressive chromatin structure composed of deacetylated histones.

157 SirT1 (Sir2 in Drosophila melanogaster) deacetylates histones and other proteins including trans

158 acetylation, and the sirtuin Sir2/SIRT1 that deacetylates histones and transcription factors is essen

159 ession via its association with HDAC2, which deacetylates histones H2A and H3 on the miR-155 promoter

160 The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcript

161 Silent Information Regulator 2 (Sir2) gene, deacetylates histones, p300, p53, and the androgen recep

162 duced with the treatment of apelin-13, which deacetylates histones.

163 to generate chromatin structures, with Sir2 deacetylating histones and Orc1 binding to these deacety

164 Some may alter cell cycle progression by deacetylating histones and repressing transcription of k

165 Hos2, and Hda1 have overlapping functions in deacetylating histones and suppressing cotranscriptional

166 HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter, thereby

167 HARP, recruiting SMRT, activating HDAC3, and deacetylating histones to exclude Pol II across the X ch

168 further demonstrate that Sirt1 interacts and deacetylates homologous recombination (HR) repair machin

169 We show that SIRT1 deacetylates HSF1 (heat shock factor 1) and increases HS

170 biquitin ligase GP78 preferentially binds to deacetylated HSPA5.

171 to levels similar to LPS, whereas partially deacetylated hyaluronan had no stimulatory effect, indic

172 ing of ischaemia-reperfusion injury, RIP1 is deacetylated in a SIRT2-dependent fashion.

173 histones at the Rgs10 proximal promoter are deacetylated in BV-2 microglia following LPS activation,

174 cGAS is deacetylated in response to DNA challenges.

175 s on Ssa1, K86, K185, K354 and K562 that are deacetylated in response to heat shock.

176 LCAD is deacetylated in wild-type mice under fasted conditions a

177 ed at low levels in the nucleus, albeit in a deacetylated, inactive state.

178 SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phospho

179 as previously been shown to activate HSF1 by deacetylating it, leading to increased DNA binding abili

180 tylase sirtuin 2 (SIRT2) associated with and deacetylated K8.

181 The association of deacetylated LC3 with autophagic factors shifts LC3's di

182 In T-ALL, deacetylated LMO2 induces expression of TAL1 complex tar

183 s of nutrients were reversed by SIRT3, which deacetylates lys(101) acetylation.

184 ot deacetylation null Sirt3 into Sirt3/ MEFs deacetylated lysine and restored MnSOD activity.

185 zed to purify the substrate and identify the deacetylated lysine by MS.

186 Although early studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD(+),

187 ondrial reactive oxygen species, in part, by deacetylating manganese superoxide dismutase (MnSOD) and

188 ylan esterases (AcXEs); however, the enzymes deacetylating mannans are less understood.

189 racts aging- and obesity-related diseases by deacetylating many proteins, but whether SIRT1 has a rol

190 s phosphorylation, whereas Sirtuin 2 (SIRT2) deacetylated MARCKS.

191 protein regulated by SIRT1, which binds and deacetylates Mcm10 both in vivo and in vitro, and modula

192 We show in this article that PAF and its 2-deacetylated metabolite (lysoPAF) promote degranulation

193 le only minimal amounts of the corresponding deacetylated metabolite of 10 were observed in hepatocyt

194 re samples of alphaTAT1-acetylated and SIRT2-deacetylated microtubules to visualize the structural co

195 441C, Y1699C) preferentially associates with deacetylated microtubules, and inhibits axonal transport

196 1B-1 antibody recognizes both acetylated and deacetylated microtubules.

197 dative stress was dependent on IDH2, and the deacetylated mimic, IDH2(K413R) variant was able to prot

198 HDAC6 interacts with and deacetylates MLH1 both in vitro and in vivo Interestingl

199 and the histone acetylation activity of the deacetylated MOF were found to be very close to that of

200 nd that the autoacetylation rates of MOF and deacetylated MOF were much slower than the cognate subst

201 t with MSH2, HDAC10 is the major enzyme that deacetylates MSH2 at Lys-73.

202 C terminus, and histone deacetylase (HDAC6) deacetylates MSH2.

203 Deacetylated MT accumulation resulted in Golgi fragmenta

204 A sirtuin-like enzyme can deacetylate multiple FadDs, thus completing the regulato

205 ially deacetylated, whereas several major PG-deacetylated muropeptides are absent or significantly re

206 Here we tested the hypothesis that HDAC3 deacetylates MutSbeta and thereby activates it to drive

207 lized to A-band of sarcomeres and capable of deacetylating myosin heavy chain (MHC) isoforms.

208 the A band of sarcomeres and was capable of deacetylating myosin heavy chain (MHC) isoforms.

209 The N-deacetylated N-(2'-deoxyguanosin-8-yl)-7-fluoro-2-aminof

210 of alpha-1,4-linked galactose and partially deacetylated N-acetylgalactosamine (GalNAc).

211 e we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulate

212 Thus, Sirt1, by deacetylating Nav1.5, plays an essential part in the reg

213 NF-kappaB, and the full capacity of AMPK to deacetylate NF-kappaB and inhibit its signaling requires

214 MPK activation mimics the effect of SIRT1 on deacetylating NF-kappaB, and the full capacity of AMPK t

215 Furthermore, in Mtb specific T cells, SIRT2 deacetylates NFkappaB-p65 at K310 to modulate T helper c

216 , it is found associated with HDAC5, whereas deacetylated Nkx2.5 is in complex with p300.

217 Like most histone deacetylases, SIRT1 also deacetylates nonhistone proteins.

218 Sirt1 operates as a pH-sensor that deacetylates nuclear eIF5A during anaerobiosis, enabling

219 Here we report that SIRT6 binds to and deacetylates nuclear PKM2 (pyruvate kinase M2) at the ly

220 tains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related

221 etylating histones and Orc1 binding to these deacetylated nucleosomes through its BAH domain.

222 luding significant amounts of Sir3 and H4K16 deacetylated nucleosomes.

223 ators FOG1 and the nucleosome remodeling and deacetylating (NuRD) complex.

224 he rate at which histones are acetylated and deacetylated on a residue-specific basis has not been qu

225 The C. difficile peptidoglycan is largely N-deacetylated on its glucosamine (93% of muropeptides) th

226 tochondrial deacetylase SIRT3 was capable of deacetylating OPA1 and elevating its GTPase activity.

227 between cryo-EM reconstructions of maximally deacetylated or acetylated microtubules.

228 In contrast, sirt3(-/-) mice failed to deacetylate OTC in response to CR.

229 al analysis demonstrated that Sirt3 directly deacetylates OTC and stimulates its activity.

230 ifs, which selectively recruit an NcoR-Hdac3-deacetylated-p50 repressosome to inflammatory genes.

231 HDAC8 aberrantly deacetylates p53 and promotes LSC transformation and mai

232 energy starvation, SIRT1 interacts with and deacetylates PABP1 and deactivates its poly(A)RNA bindin

233 In SCs, we found that Sirt2 deacetylates Par-3, a master regulator of cell polarity.

234 SIRT1 physically binds to and deacetylates PARP1.

235 Upon binding, SIRT7 deacetylates PCAF at lysine 720 (K720), which augments P

236 Furthermore, Sir2p deacetylated Pck1p both in vitro and in vivo.

237 2, a deacetylase, plays an important role in deacetylating PEPCK1 and little is known about the anti-

238 DslA, which acts, unusually, upon (GlcNAc-) deacetylated peptidoglycan.

239 cancer-1 (Dbc1) promote "browning" of WAT by deacetylating peroxisome proliferator-activated receptor

240 Notably, ectopic overexpression of a deacetylated PKM2 mutant in Sirt2-deficient mammary tumo

241 9GlcNH(2), in place of chemically partially deacetylated PNAG, three conjugate vaccines consisting o

242 Thus, the deacetylated polysaccharide chitosan potently activates

243 SirT2 binds and deacetylates PR-Set7 at K90, modulating its chromatin lo

244 g enzyme PARP1 was deactivated and the major deacetylated protein was identified to be an E3 protein

245 o-arginine (KR) mutant of LRP130 that mimics deacetylated protein.

246 Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAAD

247 t regulator in CR adaptation by coordinately deacetylating proteins involved in diverse pathways of m

248 their moisture absorption ability (MAA) and deacetylating reaction were investigated and compared wi

249 The NAD+-dependent protein SIRT1 deacetylates RECQL4 in vitro and in cells thereby contro

250 During this initial process, SIRT1 deacetylated RelA/p65 lysine 310 and nucleosomal histone

251 The method permits labeling of deacetylated residues with amine-reactive biotin on the

252 Sirt1 deacetylates retinoblastoma (Rb) in the Rb/E2F1 complex,

253 Deacetylated Rtt109 was prepared by reacting with a sirt

254 SIRT1 deacetylates S6K1, thereby enhancing its phosphorylation

255 tuting the lysine at residue 633, one of the deacetylated sites of HDAC6, with a glutamine resulted i

256 xpression of key TGF-beta signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and

257 beta2(TGF-beta2)-induced EMT of RPE cells by deacetylating SMAD4.

258 We provide direct evidence that Hos1 can deacetylate Smc3 and retains a soluble pool of deacetyla

259 acetylate Smc3 and retains a soluble pool of deacetylated Smc3.

260 yeast, the class I histone deacetylase Hos1 deacetylates SMC3 during anaphase.

261 are needed to maintain AcsA as active (i.e., deacetylated) so the cell can grow with low concentratio

262 Our data reveal that SIRT1 can directly deacetylate SREBP, and modulation of SIRT1 activity resu

263 Conversely, mutations mimicking the deacetylated state (KR series) promote FoxO1 nuclear ret

264 indicate that Aurora B is more active in its deacetylated state and further suggest a new mechanism b

265 f SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetylt

266 ly, SMAR1 through HDAC6 maintains Sam68 in a deacetylated state.

267 annose adjacent to the mannose residue being deacetylated (subsite -1 and +1).

268 PelA(h) hydrolyzed partially deacetylated substrates better than Sph3(h), a finding t

269 Together, these data imply that HDAC6 deacetylates survivin to regulate its nuclear export, a

270 cleus following CBP activation where it then deacetylates survivin.

271 t1 requires autodeacetylation to efficiently deacetylate targets such as p53, H3K9, and H4K16.

272 HDAC6 not only deacetylates tau but also suppresses tau hyperphosphoryl

273 Both HDAC4 and HDAC5 deacetylate TBX5, which promotes its relocation to the c

274 effects were due to the ability of SIRT1 to deacetylate the FOXO3 transcription factor, since Foxo3

275 s Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence e

276 3K36me on one nucleosome stimulates Rpd3S to deacetylate the neighboring nucleosomes when those two n

277 B. bacteriovorus are known to deacetylate the peptidoglycan of the prey bacterium, gen

278 LAP2beta for GLI1 while scaffolding HDAC1 to deacetylate the secondary binding site.

279 NAD(+)-dependent deacetylase, bound TUG and deacetylated the TUG peptide.

280 SIRT1 deacetylates the brain-specific helix-loop-helix transcr

281 ndria of SIRT3-null mice, and SIRT3 directly deacetylates the ceramide synthases in a NAD(+)-dependen

282 We previously showed that Hdac3 deacetylates the p65 subunit of the NF-kappaB transcript

283 The intracellular enzyme that deacetylates the PAF (PAFAH1B) is composed of a tetramer

284 fers protection against polyQ-expanded AR by deacetylating the AR at lysines 630/632/633.

285 SIRT1 promotes catabolic gene expression by deacetylating the forkhead factor FOXO in response to st

286 SIRT2 promotes AMPK activation by deacetylating the kinase LKB1.

287 We found that either deacetylating the microtubules via overexpression of HDA

288 how that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid rec

289 allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby

290 eover, we identified SIRT1 that specifically deacetylates TIP60 and negatively regulates TIP60 activi

291 a-D-Glcp-O-iPr (23), which was selectively S-deacetylated to give 25.

292 glucose deprivation, SIRT1 is activated and deacetylates TopBP1, resulting in TopBP1-Treslin disasso

293 Sirtuin research has focused on SirT1, which deacetylates transcription factors and cofactors in the

294 its was markedly improved in the presence of deacetylated tRNA, emphasizing the importance of tRNAs d

295 This suggested that deacetylated-tubulin might be more prevalent in depressi

296 roach, we describe the ability of Sirt1-3 to deacetylate two adjacent acetylated lysine residues.

297 ld-type C. difficile is intrinsically highly deacetylated, we have found that exposure to lysozyme le

298 The parent strain PG is partially deacetylated, whereas several major PG-deacetylated muro

299 SIRT1 deacetylates XPA both in vitro and in cells.

300 ing CBM reduced the capacity of esterases to deacetylate xylan in tobacco walls.