ライフサイエンスコーパス: deacetylation

1 s (mono/poly-ADP-ribosylation) and sirtuins (deacetylation).

2 tentially be a substrate for SIRT-1 mediated deacetylation.

3 graftment of T-ALL cells via diminished LMO2 deacetylation.

4 e p53 protein and modulates p53 activity via deacetylation.

5 ondria and unexpectedly is a target of SIRT1 deacetylation.

6 ed and that HDAC6 promotes ERK1 activity via deacetylation.

7 nism for SIRT3 regulation via SIRT1-mediated deacetylation.

8 s required to achieve locus-specific histone deacetylation.

9 residues in Msh3 are direct targets of HDAC3 deacetylation.

10 f non-coding RNA silencing and histone H4K16 deacetylation.

11 panied by noticeable backbone degradation or deacetylation.

12 rease in SIRT1-MTORC2 interaction and RICTOR deacetylation.

13 methylation, histone methylation, or histone deacetylation.

14 d repressed transcription of Il6 via histone deacetylation.

15 regulation of alternative splicing via Sam68 deacetylation.

16 ular redox potential via HDAC3-mediated PGK1 deacetylation.

17 romotes HDAC3-PGK1 interaction and PGK1 K220 deacetylation.

18 zymes responsible for tubulin acetylation or deacetylation.

19 ues have been matched to a proposed KDAC for deacetylation.

20 es of lysine deacetylases contributed to FUS deacetylation.

21 core are essential for proficient substrate deacetylation.

22 and could be inhibited by SIRT1 via histone deacetylation.

23 nregulated by acetylation and reactivated by deacetylation.

24 hrough Sirt1 recruitment followed by histone deacetylation.

25 n via histone deacetylase 1-mediated histone deacetylation.

26 ied compounds that activated histone peptide deacetylation 18-48-fold.

27 etyltransferases (HATs) are involved in MSH2 deacetylation/acetylation is unknown.

28 her posttranslational modifications, such as deacetylation/acetylation, methylation, and ubiquitinati

29 emonstrates that DNA methylation and histone deacetylation act largely independently to suppress tran

30 Mechanistically, Klf5 deacetylation activates Notch signaling.

31 Nonetheless, the deacetylation activity by HDAC3 in the complex was evide

32 we were able to analyse desuccinylation and deacetylation activity in multiple cell lines using this

33 Deacetylation activity of certain sirtuins was detected

34 , which then releases SIRT1 and enhances its deacetylation activity.

35 tude greater for long-chain deacylation than deacetylation against peptide substrates; however, deace

36 Inhibition of histone deacetylation altered the dynamics of CSB assembly, sugg

37 demonstrate that SIRT1 induction causes the deacetylation and activation of FOXO3a in NAc, which lea

38 The SIRT2-mediated deacetylation and activation of G6PD stimulates PPP to s

39 imal structural elements required for lysine deacetylation and catalytic activation by small molecule

40 sal breast cancer cell lines through histone deacetylation and CpG methylation of the promoter region

41 eate a hitherto-unknown mechanism of protein deacetylation and deacetylimination catalyzed by lysyl o

42 triggered by Lsd1-Mi2/NuRD-mediated histone deacetylation and demethylation at these pluripotency ge

43 genetic regulators necessary for (i) histone deacetylation and demethylation, (ii) binding to methyla

44 ce of conserved active site residues in PNAG deacetylation and demonstrate that the C-terminal domain

45 fication of FoxO3, including early (6 hours) deacetylation and dephosphorylation that coincide with l

46 scriptional gene silencing (TGS) via histone deacetylation and DNA methylation.

47 estigated the mechanisms of activated lysine deacetylation and enhanced long-chain acyl-group removal

48 h the induction of SIRT2, leading to ALDH1A1 deacetylation and enzymatic activation to promote breast

49 last differentiation in part through histone deacetylation and epigenetic suppression of an alternati

50 nucleation region in vivo, promoting histone deacetylation and FLC transcriptional silencing, and int

51 tion repression activity of Tet2 via histone deacetylation and for the prevention of constant transcr

52 ad into genes only in the context of histone deacetylation and gene silencing.

53 This reveals histone deacetylation and H2AK119 ubiquitination as the earliest

54 activity is largely responsible for histone deacetylation and inflammatory responses of primary micr

55 However, its impact on N-deacetylation and lysozyme resistance is limited, and it

56 However, the alteration of histone deacetylation and miR-193b-3p and Rad51 expression in re

57 ssion via a dual mechanism involving histone deacetylation and nucleosome remodeling.

58 icate that MutSbeta is a key target of HDAC3 deacetylation and provide insights into an innovative re

59 o SIRT1-mediated p53 and histone 3 lysate 56 deacetylation and results in reduced EC senescence in vi

60 ular iron homeostasis via regulation of NRF2 deacetylation and stability.

61 B kinase)-alpha and beta, resulting in their deacetylation and subsequent activation, which drives in

62 ion by influencing fasting-dependent histone deacetylation and subsequent chromatin modifications wit

63 functional link between SIRT7-mediated H3K18 deacetylation and the maintenance of genome integrity.

64 the enzymes responsible for peptidoglycan N-deacetylation and their respective regulation.

65 1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.

66 haride composition analysis indicated that N-deacetylation and/or N-desulfation may have taken place.

67 d probes for chitosan (the product of chitin deacetylation) and for demethylesterified homogalacturon

68 ons, acetylated histone 3 on lysine 9 and 14 deacetylation, and acetylated histone 3 on lysine 9 meth

69 ates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes to co

70 erse modifications: DNA methylation, histone deacetylation, and histone methylation.

71 ehavioral abnormality, chemokinesis, histone deacetylation, and immunity.

72 sed carboxypeptidase activities, increased N-deacetylation, and increased O-acetylation in VRE when g

73 enetically modulate DNA methylation, histone deacetylation, and lysine demethylation.

74 ation-induced PABP1-SIRT1 association, PABP1 deacetylation, and poly(A)RNA nuclear retention.

75 ivity can be modulated by lysine acetylation-deacetylation, and prevention of TopA inactivation from

76 histone deacetylase 6 (HDAC6)-mediated RelA deacetylation, and thus enhances transcriptional activit

77 NAMPT/SIRT2-mediated activation of LMO2 by deacetylation appears to be important for hematopoietic

78 n activity or affected for histone H4 Lys-16 deacetylation are impaired, at least in part, for telome

79 DNA methylation and histone deacetylation are key epigenetic processes involved in n

80 ing of the HLA class-I APM is due to histone deacetylation as inhibition of histone deacetylases (HDA

81 morphology, levels of lamin A,C, and histone deacetylation, as these tensile stresses 1) are transmit

82 data reveal that loss of FBP1 due to histone deacetylation associates with poor prognosis of HCC and

83 HDAC1 and HDAC3 then mediated histone deacetylation at cytokine promoters and, in turn, cytoki

84 show that, in HD, ATAD3A dimerization due to deacetylation at K135 residue is required for Drp1-media

85 ranscriptional activity via reciprocal STAT3 deacetylation at Lys685 and phosphorylation at Tyr705.

86 oes not correlate with changes in histone H4 deacetylation at replication forks.

87 ures, in which it binds and triggers histone deacetylation at the promoter of the calbindin gene (Cal

88 Cs, and induced histone (H)3 methylation and deacetylation at the PTEN promoter.

89 nse to high temperature and mediates histone deacetylation at the YUCCA8 locus, a rate-limiting enzym

90 Acetylation/deacetylation at these residues alter expression of othe

91 etic mechanisms, such as histone acetylation/deacetylation balance, in part via histone deacetylase (

92 e deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence.

93 On the other hand, inhibition of histone deacetylation by an inhibitor specific to HDACs 1-3, CI-

94 s, and particularly BMAL1-Lys537 acetylation/deacetylation by CLOCK/SIRT1, were shown to be critical

95 amptothecin-induced DNA damage promotes RRM2 deacetylation by enhancing Sirt2-RRM2 interaction.

96 Here we find that Smc3 deacetylation by Hos1 has a more immediate effect in the

97 ohesin association with chromosomes, and its deacetylation by Hos1 in anaphase allows re-use of Smc3

98 Functionally, preventing histone deacetylation by increasing nucleocytoplasmic acetyl-CoA

99 Fatty acids (FAs) prevented CIDEC deacetylation by promoting the dissociation of CIDEC fro

100 cRNA transcription that targets H3K36me3 and deacetylation by Rpd3S to the mRNA promoter.

101 ted in the nucleus during starvation through deacetylation by the nuclear deacetylase Sirt1.

102 re, pharmacologically induced SIRT1-mediated deacetylation can attenuate aberrant NEDD4-mediated HSF1

103 ylation against peptide substrates; however, deacetylation can be enhanced by allosteric small-molecu

104 thylation/demethylation, histone acetylation/deacetylation, chromatin remodeling, DNA methylation, an

105 ation and the deacetylase sirtuin-1-mediated deacetylation coexist to maintain CREBH acetylation stat

106 the Dleu2 promoter via inhibition of histone deacetylation combined with BSAP knockdown increased miR

107 directly with the nucleosome remodelling and deacetylation complex (NuRD) and polycomb-related comple

108 ssociated with the nucleosome remodeling and deacetylation complex SHREC.

109 recruits the NuRD nucleosome remodeling and deacetylation complex to regulate histone acetylation an

110 The NuRD chromatin remodeling and deacetylation complex, which includes MTA1, MBD3, CHD4,

111 and NuRD (nucleosome remodeling and histone deacetylation) complex in the DNA damage response.

112 e data suggest that MSI1, HDA19, and HISTONE DEACETYLATION COMPLEX1 protein form a core complex that

113 in a subset of occluded genes, while histone deacetylation contributes to the implementation but not

114 ation, we tested the hypothesis that histone deacetylation contributes to the maintenance of chronic

115 neated a novel pathway through which histone deacetylation could contribute to CORT regulation of GR

116 Here, we describe protein deacetylation coupled with deacetylimination as a functi

117 Eukaryotic histone deacetylation, critical for maintaining nucleosome struc

118 Thus, an acetylation-deacetylation cycle ensures that LC3 effectively redistr

119 Therefore, how the acetylation/deacetylation cycle is regulated is an important questio

120 controlled in part by a dynamic acetylation/deacetylation cycle.

121 Loxl3-mediated deacetylation/deacetylimination disrupts Stat3 dimerizat

122 ther LOX family members can catalyze protein deacetylation/deacetylimination.

123 cetylation increases, whereas HDAC3-mediated deacetylation decreases, ELL stability through polyubiqu

124 inducing a lactate-dependent, SIRT1-mediated deacetylation/degradation of T-bet transcription factor;

125 s with different structural features, namely deacetylation degree (5-91%) and molecular weight (24-46

126 e efficiency of reduction increased with the deacetylation degree and applied dose.

127 Results show that chitosan with high deacetylation degrees, including fungal chitosan, which

128 HDA6 regulates polyadenylation in a histone deacetylation-dependent manner in Arabidopsis.

129 sed that FoxO proteins are activated through deacetylation-dependent nuclear translocation to foresta

130 at mitochondrial GOT2 is acetylated and that deacetylation depends on mitochondrial SIRT3.

131 e expression signature associated with FoxO1 deacetylation differs from wild type by only approximate

132 LMO2 deacetylation enables LMO2 to interact with LIM domain b

133 Smc3 deacetylation facilitated removal of cohesins from chrom

134 Deacetylation followed by regioselective phosphorylation

135 respond to heat stress quickly though Hsp70 deacetylation, followed by a slower, more traditional tr

136 lterations including histone acetylation and deacetylation has been demonstrated to play an important

137 m1 mRNA-3'UTRs through inhibition of histone deacetylation (HDAC) of those miRNA host genes.

138 ethylation (H3K4me) during activation; while deacetylation, histone H3 lysine 9 methylation (H3K9me)

139 largely bypassed, consistent with the direct deacetylation hypothesis.

140 nsible for the high level of peptidoglycan N-deacetylation in C. difficile and the consequent resista

141 wn in other pathogenic bacteria, a lack of N-deacetylation in C. difficile is not linked to a decreas

142 rts a central role of HDA-1-mediated histone deacetylation in heterochromatin spreading and gene sile

143 a previously unrecognized role of S6 kinase deacetylation in high glucose-induced mesangial cell hyp

144 IFICANCE STATEMENT The importance of histone deacetylation in normal brain functions and pathological

145 of differentiation through continual histone deacetylation in stem cells enables self-renewal and rap

146 acetyl-l-Lys (AcK), and subsequent enzymatic deacetylation in the host cell.

147 a critical role for histone acetylation and deacetylation in the response of neurons to injury.

148 much mechanistic detail for acetylation and deacetylation, in this review we discuss advances in the

149 s of lysine 68 to arginine (K68R), mimicking deacetylation, increased activity.

150 basal progenitor-derived luminal cells, Klf5 deacetylation increases their proliferation and attenuat

151 to drive lipid catabolism by promoting FoxO1 deacetylation independently of AKT, and in a pathway dis

152 This work suggests that SIRT6 activation of deacetylation involves a similar mechanism to improved c

153 This lysozyme-induced deacetylation is dependent upon sigma(V).

154 ype I IFN-dependent manner and that the CDK9 deacetylation is essential for STAT1 phosphorylation at

155 in mouse tumor models demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppre

156 acological inhibition of SIRT2-dependent p53 deacetylation is of great therapeutic interest for the t

157 COS deacetylation kinetics revealed that BsPdaC operates by

158 Promoting eEF1A1 deacetylation maintains the activation of Sox10 target g

159 at local competition between acetylation and deacetylation may play a critical role in the resolution

160 e shoot apex in parallel with MP via histone-deacetylation mediated transcriptional silencing of STM.

161 e 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to the plas

162 The deacetylation mimetic mutant, but not the WT and the ace

163 ess phosphorylation than the WT enzyme and a deacetylation-mimicking mutant (K72R).

164 enzymes known as N-deacetylases, and this N-deacetylation modulates host-pathogen interactions, such

165 show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex oppose

166 cruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin.

167 hin the mammalian Nucleosome Remodelling and Deacetylation (NuRD) complex: Mta1, Mta2 and Mta3.

168 Nucleosome remodeling and deacetylation (NuRD) complexes are co-transcriptional re

169 Histone deacetylation occurred after transcriptional repression.

170 s the site where fasting-induced acetylation/deacetylation occurs.

171 ease, it was shown that AnCDA catalyses mono-deacetylation of (GlcNAc)2 and full deacetylation of (Gl

172 ses mono-deacetylation of (GlcNAc)2 and full deacetylation of (GlcNAc)3-6 in a non-processive manner.

173 The deacetylation of a diacetoxytetraindole formed the basis

174 We blocked deacetylation of ac-SMC3 using an HDAC8-specific inhibit

175 Histone deacetylases (HDACs) catalyze deacetylation of acetyl-lysine residues within proteins.

176 ic catalysis, and assays that measured SIRT2 deacetylation of acetylated alpha-tubulin revealed that

177 se family comprises 18 enzymes that catalyze deacetylation of acetylated lysine residues; however, th

178 Deacetylation of actin in the CAP/KAc-actin complex acti

179 at the internal GlcNAc units and leading to deacetylation of all but the reducing-end GlcNAc residue

180 tes HDAC6, thereby increasing HDAC6-mediated deacetylation of alpha-tubulin.

181 osis, and tumorigenesis, and its role in the deacetylation of APE1 after genotoxic stress.

182 ates mitochondrial ceramide biosynthesis via deacetylation of ceramide synthase (CerS) 1, 2, and 6.

183 hypothesis that IR triggers SIRT3-dependent deacetylation of ceramide synthases and the elevation of

184 /reperfusion (IR) showed that SIRT3-mediated deacetylation of ceramide synthases increased enzyme act

185 propose that CnCda4 is used for the further deacetylation of chitosans already exposed on the C. neo

186 rming growth factor beta1 (TGFbeta1)-induced deacetylation of contactin, EMT, phosphorylation of Smad

187 This occurred in parallel with the deacetylation of cortactin, a nonhistone substrate of HD

188 t evolutionarily conserved sites disrupt its deacetylation of DNA-damage response proteins by impairi

189 Deacetylation of FOXO3 by SIRT activation or SIRT1 or SI

190 n was critical for recognition and efficient deacetylation of free tubulin dimers both in vitro and i

191 EMT is accompanied by rapid HDAC6-dependent deacetylation of heat shock protein 90 (HSP90).

192 findings suggest that reduced SIRT1-mediated deacetylation of HIF-1alpha contributes to the elevated

193 Specifically, deacetylation of histone 3 at lysine 9 (H3K9), through t

194 ression and other cellular functions through deacetylation of histone and nonhistone proteins.

195 ates which revealed a notable preference for deacetylation of histone H3 acetyl-Lys9 vs. acetyl-Lys14

196 s through multiple pathways that include the deacetylation of histone H3 and repression of transcript

197 enhancer-promoter communication and prompted deacetylation of histone H3 in the HNF4alpha P1 promoter

198 tion triggered by H3 S10 phosphorylation and deacetylation of histone H4 promote short-range compacti

199 nal modifications, including acetylation and deacetylation of histones and other proteins, modulate h

200 HDA6 is required for the deacetylation of histones around DNA on nucleosomes, whi

201 tions couple productive binding to efficient deacetylation of histones on endogenous chromatin.

202 ubiquitylation, methylation, sumoylation and deacetylation of histones, which maintains transcription

203 anistic insights into the understanding that deacetylation of HSPA5 by HDAC6 facilitates GP78-mediate

204 nes, and this effect is largely dependent on deacetylation of IDH2 and SOD2.

205 nance and proper luminal differentiation, as deacetylation of Klf5 causes excess basal-to-luminal dif

206 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3

207 he C-terminal domain is required for maximal deacetylation of longer PNAG oligomers.

208 Specifically, LRRK2 promoted the deacetylation of Lys-5 and Lys-12 on histone H4, causing

209 nspired by the posttranslational acetylation/deacetylation of lysine residues, in which a protein enc

210 g effects of Sirt1 evidently result from the deacetylation of many transcription factors and co-facto

211 This release correlates with rapid deacetylation of matrix proteins, and SIRT3 is required

212 These include the deacetylation of methyl ketones, carbenoid-free formal h

213 d Ca(2+) These data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhi

214 MAG- and CSPG-dependent deacetylation of Miro1 requires RhoA/ROCK activation and

215 phy and doxorubicin (Dox)-cardiotoxicity via deacetylation of mitochondrial proteins.

216 nts but, rather, occurred via SIRT3-mediated deacetylation of mitochondrial SOD2, leading to SOD2 act

217 LH1 both in vitro and in vivo Interestingly, deacetylation of MLH1 blocks the assembly of the MutSalp

218 disrupts the MutSalpha-MutLalpha complex by deacetylation of MLH1, leading to the tolerance of DNA d

219 orms together with a close homolog HDAC2, is deacetylation of new histone H4 deposited at replication

220 ytes and that puerarin led to SIRT1-mediated deacetylation of NF-kappaB and suppression of NOX4 expre

221 Consequently, the deacetylation of p53 reduces the transcription of a spec

222 Because deacetylation of p53 regulates its effect on apoptosis,

223 ocation of p53 resulting from SIRT1-mediated deacetylation of p53.

224 300-mediated acetylation and HDAC2-dependent deacetylation of PD-L1.

225 iplasm and that this may allow for efficient deacetylation of PEL before its export from the cell.

226 The K m and k cat of AnCDA for the first deacetylation of penta-N-acetyl-chitopentaose are 72 mic

227 ore and potent activation of Sirt6-dependent deacetylation of peptide substrates and complete nucleos

228 of SIRT1, resulting in FGF21/SIRT1-dependent deacetylation of PGC-1alpha and induction of the brownin

229 DAC3 coactivation of ERRalpha is mediated by deacetylation of PGC-1alpha and is required for the tran

230 irement of a C-terminal domain for efficient deacetylation of PNAG in Gram-negative species.

231 The two-stage nitration and subsequent deacetylation of readily available 1,3-dicarbonyl compou

232 sensing activity and that the HDAC6-mediated deacetylation of RIG-I is critical for viral RNA detecti

233 rough histone deacetylase 6 (HDAC6)-mediated deacetylation of RNA-binding protein Sam68 (Src-associat

234 In vitro acetylation/deacetylation of SacAcsA enzyme was studied by Western b

235 esents detailed kinetics for HDAC8-catalyzed deacetylation of singly-acetylated, full-length protein

236 ncreased SirT-1 protein levels and increased deacetylation of SirT-1 targets involved in DNA repair.

237 HDAC1 activates PU.1 gene transcription via deacetylation of TATA-binding protein-associated factor

238 HDAC9 promoter by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events dur

239 We demonstrate that HDAC8 catalyzes deacetylation of tetrameric histone (H3/H4) substrates w

240 s demonstrate consistency with the degree of deacetylation of the obtained chitosan, allowing the dif

241 the reducing end sugar was much slower than deacetylation of the other sugars in chito-oligomers.

242 Deacetylation of the reducing end sugar was much slower

243 SKI controls histone acetylation and deacetylation of the Rorc locus and TH17 cell differenti

244 Here, we report that acetylation and deacetylation of the RRM2 subunit of RNR acts as a molec

245 may alter the preproPC2 gene directly or via deacetylation of the transcription factor Forkhead box p

246 0 increases TULP3 protein abundance and that deacetylation of these sites by HDAC1 decreases protein

247 on of the DNA damage response prevents SIRT1 deacetylation of TopBP1, resulting in a switch from DNA

248 ted step in the biosynthesis of lipid A, the deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)

249 ion of enzymes that regulate acetylation and deacetylation offers much potential for inhibiting cance

250 ally, given the influence of peptidoglycan N-deacetylation on host defense against pathogens, we inve

251 re, we demonstrate that LMO2 is activated by deacetylation on lysine 74 and 78 via the nicotinamide p

252 BpsB displays metal- and length-dependent deacetylation on poly-beta-1,6-N-acetyl-d-glucosamine (P

253 miR-193b-3p expression was caused by histone deacetylation on the miR-193b-3p promoter in the HepG2 c

254 ric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telomeres an

255 As a result of SIRT6-mediated deacetylation, PKM2 nuclear protein kinase and transcrip

256 These results indicate that peptidoglycan deacetylation plays an important role in modulating host

257 lation at the promoter, H2Bubi initiates the deacetylation process, which decreases chromatin remodel

258 d that the cAMP pathway participates in this deacetylation process.

259 PP/p25 counteracts the SIRT2-derived tubulin deacetylation producing enhanced microtubule acetylation

260 We also investigated the effect of CnCda4 deacetylation products on human peripheral blood-derived

261 ypothesis where the acetate byproduct of the deacetylation reaction escapes via the 14 A internal cav

262 specificity a conserved Pro, shares with the deacetylation reaction the same active site and one cata

263 , cyclophilin D, and Hsp10, and analyzed the deacetylation reaction.

264 er a mechanism by which PARN acetylation and deacetylation regulate its enzymatic activity as well as

265 Sirt-1 deacetylation regulates different transcription factors

266 esults demonstrate that SIRT7-mediated H3K18 deacetylation regulates L1 expression and promotes L1 as

267 deacetylases are involved in peptidoglycan N-deacetylation remains unknown.

268 n of H3K4 and consequent promoter nucleosome deacetylation repress ste11 induction and cell different

269 anscription via modulation of H3 acetylation/deacetylation, respectively, through competition for bin

270 the acetyl group pool and catalyzing lysine deacetylation, respectively-was developed to model extre

271 that are involved in histone acetylation and deacetylation result in multiple congenital anomalies wi

272 tion by p300 overexpression or inhibition of deacetylation resulted in increases of Ser-294 phosphory

273 SIRT6-mediated deacetylation results in PKM2 nuclear export.

274 Deacetylation sites in Msh3 overlap a nuclear localizati

275 In turn, HDAC9 directly maintained the deacetylation status of the key PRR signaling molecule T

276 mophore maturation, and is also an efficient deacetylation substrate for sirtuins.

277 in the range of 8-35 muM and increased H4K16 deacetylation, suggesting a possible role for SIRT1 acti

278 ethylation, as well as HCHC-mediated histone deacetylation, suggesting that spreading is dependent on

279 ture models, we identified a candidate SIRT2 deacetylation target at PKM2 lysine 305 (K305).

280 concert with enrichment of H4K16ac (itself a deacetylation target of SIRT1), which is associated with

281 -chain acyl-CoA dehydrogenase, a known SIRT3 deacetylation target; improved fatty acid beta-oxidation

282 onsensus sequence can direct acetylation and deacetylation targeting by these enzymes in vivo Remarka

283 Whereas SIRT1 exhibits diversity in deacetylation targets and subcellular localization, SIRT

284 e genome-wide waves of H3K56 acetylation and deacetylation that occur during each cell cycle.

285 on/de-ubiquitination and histone acetylation/deacetylation, the repressive histone methyl transferase

286 on by inhibiting SIRT1-mediated beta-catenin deacetylation, thereby enhancing LEF1-beta-catenin compl

287 usly shown that resistant BCCs increase GLI1 deacetylation through atypical protein kinase Ciota/lamb

288 coupled with pseudodisaccharide followed by deacetylation to produce the acceptor, which on subseque

289 umerous transcription factors in response to deacetylation to promote mitochondrial biogenesis and ox

290 w that the RIG-I C-terminal region undergoes deacetylation to regulate its viral RNA-sensing activity

291 Insulin promotes K220 deacetylation to stimulate PGK1 activity.

292 cohesion in early anaphase; subsequent Smc3 deacetylation, triggered by Scc1 cleavage, is also requi

293 tion of proinflammatory cytokines, partial N-deacetylation was carried out by hydrazinolysis.

294 To determine the mechanism of S6 kinase deacetylation, we found that trichostatin A, a pan-histo

295 sms, including histone modifications such as deacetylation, we tested the hypothesis that histone dea

296 ch CUDC-907 dually inhibits PI3K and histone deacetylation were assessed using reverse protein array,

297 of cells with nitro-oleic acid promoted H3K9 deacetylation, whereas oleic acid had no effect.

298 matin binding genome-wide through PER2(K680) deacetylation, which in turn primes PER2 phosphorylation

299 One critical PTM is acetylation/deacetylation, which is being investigated as a means to

300 was found to be a direct substrate of SIRT6 deacetylation, with a mechanism that up-regulates NAMPT