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1 tics that ancestral TEM-1 had been unable to deactivate.
2 ause these catalyst particles to permanently deactivate.
3 osphatase and tensin homolog (PTEN) has been deactivated.
4 prove when channels with high thresholds are deactivated.
5 af auditory cortex, the dorsal zone (DZ), is deactivated.
6 channel to be either heat-activated or heat-deactivated.
7 ional activity, it also needs to be properly deactivated.
8 ussions; and 2) having the shocking function deactivated.
9 In contrast, the triafulvenyl group is deactivating.
10 support a model whereby STIM1 is critical to deactivate a key negative regulator of cardiac hypertrop
11 tivate a TTX-sensitive Na(+) conductance and deactivate a resting Ih conductance, leading to a striki
12 h protein partners with a cellular kinase to deactivate a silencer of the lytic switch protein, there
14 sites, we also observed heterotopic effects; deactivating a specific domain in M1 (e.g., forelimb lif
15 equently, the same prefrontal cortical areas deactivated after a painful experience had been reached.
17 a), N(alpha)-dicarboxymethyllysine (NTA) and deactivating agents to block non-selective binding betwe
19 ladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenz
21 ocortical population activity varies between deactivated and activated states marked by the presence
22 pain, the medial prefrontal cortex (mPFC) is deactivated and mPFC-dependent tasks such as attention a
23 OE mice, the NAD+-consuming enzyme PARP1 was deactivated and the major deacetylated protein was ident
24 ring dehydration and rehydration, C. pumilum deactivates and activates partial components of the phot
25 TP with high- and (d) low-threshold channels deactivated, and (e) MP with high- and (f) low-threshold
29 tion reactions with only 1.2 equiv activated/deactivated arenes (no additional solvent) to access str
31 patch currents activated rapidly (<1 ms) and deactivated as a function of the alpha-subunit, with alp
32 king and regulatory capabilities, but become deactivated as the inflammation subsides, thus avoiding
35 nts had their left ventricular assist device deactivated before death, with all but 3 undergoing deac
36 gnaling state, and we also describe that D14 deactivates bioactive SLs by the hydrolytic degradation
39 The combined dataset suggests that TRX may deactivate both mitochondrial succinate dehydrogenase an
40 altered dynamics on a mus-ms time scale and deactivates both of the divalent cation-binding sites of
41 are activated by a major pre-EMT marker and deactivated by a post-EMT marker, boosting the transitio
46 Apratoxin S8 (1c) lacks the propensity to be deactivated by dehydration and showed efficacy in a huma
48 try composed of the regulator TnrA, which is deactivated by feedback-inhibited glutamine synthetase (
50 ween -6 degrees C and -20 degrees C could be deactivated by heating to 100 degrees C, which was indic
51 r biological membranes could be activated or deactivated by irradiation, thus enabling reversible pho
52 avibactam, but not the bicyclic boronate is deactivated by L1 at a low rate; the utility of avibacta
54 thalimide probe QMeNN, whose fluorescence is deactivated by photoinduced electron transfer (PeT) quen
55 d picomolar affinity for CB receptors and is deactivated by plasma esterases while the respective aci
57 switches in a family of hammerhead ribozymes deactivated by stem or loop replacement with a U-rich se
58 lite ZSM-5 crystal, which has been partially deactivated by the methanol-to-hydrocarbons reaction usi
59 nowledge of which pathways are activated and deactivated by these essential sensors is largely unknow
60 ntal gyrus (SFG) that was also sensitive to (deactivated by) demanding initial choices and another in
61 e and, therefore, like many other catalysts, deactivates by coking during reactions in hydrocarbon-ri
62 Here, we use deactivated Cas9 (dCas9) and deactivated Cas12a (dCas12a) to construct dynamic RNA ri
64 l for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain o
68 CRISPRi, in which a doxycycline-inducible deactivated Cas9 is fused to a KRAB repression domain, c
70 proaches to reduce pathogenesis by targeting deactivated Cas9 to either the DNA or the RNA repeats wi
71 tion of the sensor and kinase domains, which deactivates catalysis, increased the solvent exposure of
72 r the LQT2-causing mutation R56Q gave faster-deactivating channels that displayed an attenuated mode-
73 ich expressed the Cbfb-MYH11 fusion gene and deactivated Chd7 in hematopoietic cells upon inducing Cr
74 ted K(+) channel for the activated, open and deactivated, closed states of the channel under depolari
75 eling approaches for the activated, open and deactivated, closed states of three different voltage-ga
76 emonstrating that the formation of the first deactivating coke precursor molecules occurs in nanoscop
77 nd) and the evolution of active species into deactivating coke species have received less attention.
78 Hsp90-bound client can transition between a deactivating conformation and an activating conformation
79 c in both hospital and community settings by deactivating conventional beta-lactam antibiotics, inclu
80 ain may rapidly and alternately activate and deactivate cortical areas advantageous or obtrusive to f
82 the gene-targeting capacity of catalytically deactivated CRISPR-associated protein 9 (Cas9) complexed
83 d that a dCas9-VP64 system consisting of the deactivated CRISPR-associated protein 9 (dCas9) fused wi
85 known about how to specifically capture and deactivate CTCs in vivo, which may lead to successful me
86 ligomers produce strongly desensitizing fast deactivating currents and nondesensitizing slowly deacti
91 hydrodynamic force in hemorrhage and rapidly deactivated downstream, providing a paradigm for hierarc
92 e excitation light photoactivates as well as deactivates Dronpa single molecules, hindering temporal
94 ocampal overactivity was due to a failure to deactivate during loss events in comparison to controls,
95 FTP network was activated during Speech and deactivated during Count and nonverbal Decision trials,
97 s requested that their devices be removed or deactivated during the study, although their reasons for
99 al-feedback group, participants successfully deactivated EEG activity patterns of smoking cue reactiv
102 e activation is demonstrated to overcome the deactivating effect of a trifluoromethyl substituent, ma
103 ity of the bacterial outer-membrane, it also deactivates efflux pump systems by dissipating the trans
104 mined both of these hypotheses by surgically deactivating either the magnetic or olfactory sensory sy
105 lculates the likelihood of a genetic variant deactivating enhancers by disrupting the binding of tran
106 are tunable by regulating the levels of the deactivating enzyme and receptor, as well as by adjustin
108 ZmGH3.2, encoding indole-3-acetic acid [IAA] deactivating enzyme), and increased IAA in their embryo,
110 e in estrogen homeostasis by sulfonating and deactivating estrogens, but studies on the role of SULT1
112 onstrates that the clusters do not sinter or deactivate even after prolonged exposure to reactants at
113 ained, even when conducted on electronically deactivated, eventually also sterically hindered, substr
115 ediated by alpha1(T47R)beta2gamma2 receptors deactivated faster than those mediated by alpha1beta2gam
117 s established by programming TFs are rapidly deactivated following Lhx3 downregulation in stem-cell-d
125 The mass spectrometer was coupled via a deactivated fused silica capillary to an injector of a g
126 A well-defined restriction placed inside a deactivated fused silica capillary was used to increase
129 Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response
130 GS overexpression depended on its ability to deactivate Galpha, as overexpression of a biochemically
131 revealed that the DNMT3a-deficient cells had deactivated gene networks involved in calcium, endotheli
132 lpha- O-glycoside products are obtained with deactivated glycals at 75 degrees C in the presence of t
141 ashion by changing the slowly activating and deactivating I (Ks) current into an almost linear curren
143 de that pathogenic leptospiral proteases can deactivate immune effector molecules and represent poten
144 ression (CRISPRi) can be either activated or deactivated in a dose-dependent fashion over a >10-fold
145 ars ago) and show that as they activated and deactivated in different locations, their overall number
147 cture and photosystem genes were immediately deactivated in NR-KO cells following NO3(-) addition, fo
148 acute bacterial infection, T1R2/3 is likely deactivated in response to bacterial consumption of airw
151 dyl peptidase IV (DPPIV); an enzyme known to deactivate incretins, hormones involved in insulin secre
154 rotocols, which seems best attributed to the deactivating influence of the high-valent Re center.
155 nase A (PKA)-activated and calcineurin (CaN)-deactivated inhibitor of protein phosphatase 1 (PP1).
156 activity is part of a 'timing mechanism' to deactivate IRE1 immediately following engagement of the
158 T1 interacts with and deacetylates PABP1 and deactivates its poly(A)RNA binding, leading to nuclear a
160 gomers produce moderately desensitizing fast deactivating K(+) currents, whereas KCTD12 and KCTD16 ho
163 ppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in
164 ly active Rac1 at the cell edge, stathmin is deactivated locally, which establishes a spatial gradien
169 pressing cells with lumacaftor and ivacaftor deactivated macroscopic F508del-CFTR Cl(-) currents.
175 s known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences.
180 ssing differentiation of Th1 and Th17 cells, deactivating myeloid cells, inhibiting STAT activation i
181 challenging coupling reaction at the highly deactivated N-terminal position proved to be much more p
182 ry pathway in the upper cervical spinal cord deactivates neurons in the hand region in contralateral
186 ioxidant additives due to their high ability deactivating O(2)((1)Delta(g)) through a physical proces
188 rt the formation of highly electrophilic 1,1-deactivated olefins, their use as novel synthetic buildi
191 = 907) were randomized to a control (alarms deactivated) or treatment group for 6 months, after whic
192 for hybridization to a probe, and they also deactivate other closely related sequences in solution.
200 eeps it enzymatically active by blocking its deactivating phosphorylation by Mst1, a serine/threonine
201 od using proteinase K followed by heating to deactivate proteins and for safe injections into mice.
203 ing asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to
204 otassium channels in parvalbumin-type models deactivate rapidly and are unavailable for further modul
205 EPSCs cause the activated T-type channels to deactivate rather than inactivate, enabling repetitive a
208 n of Akt after 2 h of hypoxic exposure might deactivate RNA-binding protein BRF1, hence resulting in
212 talysis is determined to be CO loss from the deactivated species, [Ni(cyclam)(CO)](+), to produce the
216 that JZTx-27 stabilized the NsVBa VSM in the deactivated state and may be used as a probe to determin
217 SD4) to impede fast activation by trapping a deactivated state in which gating charge interactions br
219 cing modifies the return from inactivated to deactivated states, and the differences between splice v
222 interaction, focusing electrical fields, and deactivating subsets of channels were assessed by the ch
224 te is enabled by the solvent polarity: It is deactivated/switched-off in apolar toluene, while in pol
225 eath-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 rema
226 e of in situ electrical field stimulation to deactivate the adhesive property of catechol-containing
230 ydrodibenzo[a,e][8]annulene and irreversibly deactivate the diamagnetic molybdenum metallacyclobutadi
232 ative energy transfer, GOMs are conceived to deactivate the photoluminescence of those PLBs that are
233 in infected cells, necessitating a means to deactivate the ribonuclease once viral infection has bee
236 n, activated carbon rapidly and successfully deactivated the medications tested, suggesting activated
238 n the proportion of patients for whom the GP deactivated the template (33.6% [intervention] versus 27
239 ctivated the fronto-parietal WM networks and deactivated the typical DMN in response to increasing ta
240 ecular hydrogen bond in 1 and 2 and strongly deactivates the alpha-C-H bonds of the three substrates.
241 al ion binding to amines and amides strongly deactivates the C-H bonds of these substrates toward HAT
242 gen to Pt or Cu; and (iii) it electronically deactivates the C-H bonds proximal to the nitrogen cente
243 -ligase midline-1 (MID1), which binds to and deactivates the catalytic subunit of protein phosphatase
244 noacylglycerol lipase (MGL), the enzyme that deactivates the endocannabinoid 2-arachidonoyl-sn-glycer
245 ad to an immediate unfolding but immediately deactivates the enzyme through a combination of subtle s
247 ed-state proton transfer (ESPT) process that deactivates the excited state in competition with fluore
249 These results indicate that HSP60 silencing deactivates the mTOR pathway to suppress glioblastoma pr
254 thermodynamically disfavorable, subsequently deactivating the 1,2-H shift kinetically and thermodynam
255 ects in petroleum hydrocracking processes by deactivating the catalysts and accumulating in the downs
257 bonates form preferentially at island edges, deactivating the edge sites for CO(2) formation, even wh
258 n kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 alpha (e
262 that SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to
263 implicitly providing a handle for activating/deactivating the very first step in the redox chain.
265 damaged molecules in the nucleotide pool and deactivating them before they are incorporated into chro
266 al pathways shape PIT response properties by deactivating them while monitoring PIT activity in two m
267 ivation ensures that T-type channels rapidly deactivate, thereby limiting inactivation during repetit
268 roduced during the autoxidation are shown to deactivate these more basic RTAs, the addition of a sacr
269 electron deficiency of the amide C-H bonds, deactivating these bonds toward HAT to an electrophilic
271 teria use flagella to swim, but how bacteria deactivate this large molecular machine remains unclear.
272 serine-threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2alpha ph
273 ivated carbon-based drug disposal system for deactivating three model sedative prescription medicatio
275 The excited-state CH3O intermediate further deactivates through a seam of intersection between the g
276 pathogenic bacterium Yersinia enterocolitica deactivates TLR-induced signaling pathways, which trigge
278 assay in the device, wherein fluid flow was deactivated to allow individual reaction steps to go to
283 ys across tissue and sex, upstream activated/deactivated transcription factors were first predicted f
285 active in the non-emissive quinone form and deactivated upon reduction to the emissive dihydroquinon
288 nt scavengers than quercetin itself, able to deactivate various free radicals, under different biolog
295 vinyl monomers are efficiently activated and deactivated with light leading to excellent control over
296 pulse of glutamate (1 ms), mutant receptors deactivated with significantly slower kinetics than wild