ライフサイエンスコーパス: deacylase

1 nown trans-editing factor, MCP3, an Ala-tRNA deacylase.

2 itutes the first known extracellular protein deacylase.

3 B and D-1, respectively, by the R. etli 3-O-deacylase.

4 istinguish SIRT6 from other NAD(+)-dependent deacylases.

5 y conserved class of NAD(+)-dependent lysine deacylases.

6 such as DNA methyltransferases, and histone deacylases.

7 system, we show that plant D-aminoacyl-tRNA deacylase 1 (DTD1), of bacterial origin, is detrimental

8 cotinamide to inhibit these NAD(+)-dependent deacylase activities of the sirtuins.

9 All tested sirtuin deacylase activities showed sensitivity to NADH in this

10 -B is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity.

11 f class I leucyl-tRNA synthetase inactivates deacylase activity and produces misacylated tRNA.

12 hat there is redundancy in T.brucei inositol deacylase activity and that there is another enzyme whos

13 report 1) modulation of a bacterial sirtuin deacylase activity by acetylation, 2) that the Gcn5-rela

14 NAD(+)-dependent manner, and loss of sirtuin deacylase activity correlates with the development of ag

15 pagL) was identified by assaying for loss of deacylase activity in extracts of 14 random TnphoA::pag

16 K-12, for expression of Ca2+-dependent 3'-O-deacylase activity in membranes.

17 ork demonstrates that SseJ is an enzyme with deacylase activity in vitro and identifies three active-

18 post-translationally modify and inhibit the deacylase activity of Sirt1, Sirt2, Sirt3, Sirt5, and Si

19 However, total inositol deacylase activity was only reduced in GPIdeAc(-/-) tryp

20 n of the entire CP1 domain also disabled the deacylase activity, the deletion-bearing enzyme produced

21 HA-tagged GPIdeAc was shown to have inositol deacylase activity.

22 on in the gene (dtd) encoding D-tyrosyl-tRNA deacylase, an enzyme that prevents the misincorporation

23 SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulato

24 Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzym

25 uin 6 (SIRT6) is an NAD(+)-dependent protein deacylase and mono-ADP-ribosyltransferase of the sirtuin

26 SIRT5 is a NAD(+)-dependent lysine deacylase and removes both succinyl and malonyl groups.

27 hat HLD1/AtPGAP1 functions as a GPI-inositol deacylase and that this GPI-remodeling activity is essen

28 Both deacylase and transacylase activities were inhibited 50-

29 rial sirtuins, SIRT3-5, are NAD(+)-dependent deacylases and ADP-ribosyltransferases that are critical

30 Sirtuins are a family of deacylases and ADP-ribosyltransferases with clear links

31 7, a member of the sirtuin family of protein deacylases and mono-ADP ribosylases, protects adult hair

32 f the sirtuin family of NAD-dependent lysine deacylases and plays important roles in regulation of th

33 s that modulate sirtuin 2, an NAD+-dependent deacylase, and now report the properties of a member of

34 Thus, Notum is a Wnt deacylase, and palmitoleoylation is obligatory for the W

35 rtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate li

36 ent in sirtuin 5 (SIRT5), a NAD(+)-dependent deacylase, are hypersensitive to cardiac stress and disp

37 which is proofread by Animalia-specific-tRNA Deacylase (ATD) in vitro.

38 adenine dinucleotide (NAD)-dependent lysine deacylases, catalyzes the removal of fatty acylation fro

39 human acid ceramidase (AC; N-acylsphingosine deacylase) cleavage and activation.

40 rt that, in Salmonella enterica, the sirtuin deacylase CobB long isoform (CobB(L)) is N-terminally ac

41 The sirtuins are NAD(+) -dependent lysine deacylases, comprising seven isoforms (SIRT1-7) in human

42 ns are an ancient family of NAD(+)-dependent deacylases connected with the regulation of fundamental

43 Canavanyl-tRNA deacylase (CtdA) was recently shown to protect cells aga

44 We found that deacylase depletion increased K122 acylation on SOD1, wh

45 ene encoding the S. typhimurium lipid A 3'-O-deacylase, designated lpxR, by screening an ordered S. t

46 rystal structure of dimeric D-aminoacyl-tRNA deacylase (DTD) from Plasmodium falciparum in complex wi

47 underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discriminate between D-amino acids an

48 (EF-Tu), the ribosome, and d-aminoacyl-tRNA deacylase (DTD).

49 MC001 is homologue to lipid A deacylase enzyme (LpxR), and to our knowledge, this is t

50 entified histone delactylase activity of the deacylase enzyme Sirtuin 6 (Sirt6), a member of the Clas

51 n of the properties of SIRT2 as a long chain deacylase enzyme.

52 irtuins are NAD(+)-dependent deacetylase and deacylase enzymes that control important cellular proces

53 s a form of protein "carbon stress" that the deacylases evolved to remove as a part of a global prote

54 ession of the pagL gene encoding lipid A 3-O-deacylase from Bordetella bronchiseptica and by inactiva

55 We now describe a membrane-bound deacylase from R. leguminosarum that removes a single es

56 The deacylase gene (pagL) was identified by assaying for los

57 An inositol deacylase gene, T. brucei GPIdeAc, has been identified.

58 n-encoding genes, and lpxR, the lipid A 3'-O-deacylase gene, was reduced in low temperature and after

59 in family of NAD(+)-dependent protein lysine deacylases implicated in a variety of physiological proc

60 Sirtuins are NAD(+)-dependent protein lysine deacylases implicated in aging-related diseases.

61 ilD, including lpxR, which encodes a lipid A deacylase important for immune evasion.

62 Tiki protease in the Organizer and the Notum deacylase in presumptive neuroectoderm orchestrate verte

63 Here, we describe ABHD18 as a candidate deacylase in the CL biosynthesis pathway.

64 esting that YbaK functions as a Cys-tRNA Pro deacylase in vivo.

65 The sirtuin enzymes are important regulatory deacylases in a variety of biochemical contexts and may

66 Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes like co

67 Sirtuins are NAD(+)-dependent protein deacylases involved in metabolic regulation and aging-re

68 D-Tyr-tRNA(Tyr) deacylase is an editing enzyme that removes d-tyrosine a

69 e sirtuin family of NAD(+)-dependent protein deacylase, is critical for DLBCL growth and survival.

70 The class III lysine deacylases (KDACs), also known as the sirtuins, have eme

71 ns are the NAD(+)-dependent class III lysine deacylases (KDACs).

72 Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathoph

73 enic functions of the secreted extracellular deacylase Notum, which restricts Wg signaling by cleavin

74 some cases, the modification is reversed by deacylases of different types.

75 a periplasmic IM marker and the lipid A 3-O-deacylase PagL as an OM marker, we show that core-lipid

76 -deacylated form by heterologous lipid A 3-O-deacylase (PagL) expression.

77 expression of the P. aeruginosa lipid A 3-O-deacylase (PagL) in isolates from CF infants compared to

78 bronchiseptica contain an outer membrane 3-O-deacylase (PagL) that has been implicated in host immune

79 to regulate the expression of a lipid A 3-O-deacylase, PagL, and a lipid A palmitoyltransferase, Pag

80 The Salmonella lipid A 3-O-deacylase, PagL, is an outer membrane protein whose expr

81 PGAP1, an ortholog of the human GPI-inositol deacylase PGAP1, as a critical component required for th

82 s (SIRTs), a family of NAD-dependent protein deacylases, play a pivotal role in the regulation of the

83 RT5, a mitochondrial NAD(+)-dependent lysine deacylase, plays a key role in stabilizing GLS.

84 (SIRT5) is a NAD(+)-dependent protein lysine deacylase primarily located in mitochondria.

85 1H NMR spectroscopy of the deacylase reaction product, generated with lipid IVA as

86 The NAD(+)-dependent SIRT6 deacylase regulates aging and metabolism through mechani

87 uin 6 (Sirt6) is an NAD(+)-dependent protein deacylase regulating metabolism and chromatin homeostasi

88 Sirtuins are protein deacylases regulating metabolism and stress responses, a

89 nucleotide (NAD(+))-dependent protein lysine deacylases regulating metabolism and stress responses; h

90 Sirtuins are NAD(+)-dependent lysine deacylases, regulating a variety of cellular processes.

91 ligases were under NAD(+) -dependent sirtuin deacylase reversible lysine (de)acetylation control, fou

92 Aminoacyl-tRNA deacylases safeguard the accurate translation of the gen

93 We demonstrate that the NAD(+)-dependent deacylase SIRT2 removes the myristoyl group, and our evi

94 ere, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sirt5 knock

95 The NAD(+)-dependent lysine deacylase sirtuin 2 (Sirt2) is involved in multiple path

96 NAD(+)-dependent deacylase sirtuins have widely been recognized as positi

97 nucleotide (NAD(+))-dependent protein lysine deacylase that can remove both acetyl group and long-cha

98 The ProX protein acted as an aminoacyl-tRNA deacylase that cleaves preferentially Ala-tRNA and Gly-t

99 hages and microglial cells express an endo-N-deacylase that cleaves the N-linked fatty acid from sulf

100 sirtuin SIRT5 is an NAD(+)-dependent protein deacylase that controls several metabolic pathways.

101 Sirtuin 2 (SIRT2) is a protein lysine deacylase that has been indicated as a therapeutic targe

102 DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that removes posttranslational modifications d

103 Jhp0634 was identified as an outer membrane deacylase that removes the 3'-linked acyl chains of H. p

104 (pagL) in Salmonella typhimurium, encoding a deacylase that removes the R-3-hydroxymyristate moiety a

105 irtuin 6 (SIRT6) is an NAD-dependent protein deacylase that targets lysine residues in histones in th

106 Sirtuins are NAD(+)-dependent protein deacylases that are conserved in all domains of life and

107 nine dinucleotide (NAD(+))-dependent protein deacylases that are important for response to cellular s

108 -tRNA Pro and Cys-tRNA Cys and are also weak deacylases that cleave Gly-tRNA, Ala-tRNA, Ser-tRNA, Pro

109 Sirtuins are NAD(+)-dependent protein deacylases that cleave off acetyl but also other acyl gr

110 ily of NAD(+)-dependent protein deacetylases/deacylases that dynamically regulate transcription, meta

111 e the sirtuins, a family of NAD(+)-dependent deacylases that have evolved as coordinators of physiolo

112 namide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calo

113 Sirtuins (SIRTs) are NAD(+)-dependent deacylases that play a key role in transcription, DNA re

114 oteins are moderately general aminoacyl-tRNA deacylases that preferentially hydrolyze Cys-tRNA Pro an

115 Sirtuins are NAD(+)-dependent deacylases that regulate numerous biological processes i

116 is a member of the sirtuin family of protein deacylases that regulates metabolism and other biologica

117 Sirtuins are class III histone deacylases that use NAD(+)as a co-substrate during amide

118 Inositol deacylase was affinity labelled with [3H]DFP and purifie

119 to identify the enzyme by overexpressing 13 deacylases with potentially matching substrate specifici