1 vival response: eating the wrong food may be
deadly.
2 ely challenge because these disorders can be
deadly.
3 ents are unaware-a combination that could be
deadly.
4 oma of cerebral malaria (CM) is particularly
deadly.
5 could expect conditions equivalent to their
deadly 2015 heatwaves every year.
6 d strike when hunting venomous snakes can be
deadly [
5], so the kicking strikes of secretary birds re
7 for example reports of thalidomide causing a
deadly ADR when used against myeloma, a likely result of
8 acious investigational drugs, and unexpected
deadly adverse events.
9 In Yersinia pestis, the
deadly agent that causes plague, the protein Ail and lip
10 ential therapeutic target against mCRPC, the
deadly aggressive PCa.
11 the treatment of HIV/AIDS, transforming this
deadly ailment into a more manageable chronic infection.
12 disease virus (MDV), a highly contagious and
deadly alphaherpesvirus of chickens, we analyze the role
13 ven tumors that also emerge are particularly
deadly and becoming more prevalent.
14 d neck squamous cell carcinomas (HNSCCs) are
deadly and common cancers.
15 MDV is a
deadly and contagious herpesvirus that can kill infected
16 primary brain cancers, gliomas are the most
deadly and most refractory to current treatment modaliti
17 Infection with SARS-CoV-2 is causing a
deadly and pandemic disease called coronavirus disease-1
18 hristian; attackers who carried out the most
deadly and the least deadly strikes.
19 Glioblastoma (GBM) is a
deadly and therapy resistant malignant brain tumour, cha
20 Melanoma is one of the most
deadly and therapy-resistant cancers.
21 Head and neck cancer is disfiguring and
deadly,
and contemporary treatment has fallen short in t
22 Eating disorders are disabling,
deadly,
and costly mental disorders that considerably im
23 atitis B virus (HBV) infection is prevalent,
deadly,
and seldom cured due to the persistence of viral
24 However, 'too much of a good thing' can be
deadly,
and the excess of chaperones can be toxic under
25 s and live-attenuated viral vaccines against
deadly arenavirus pathogens.
26 It is now established that the
deadly arrhythmias are caused by unregulated 'pathologic
27 S molecular function and the epidemiology of
deadly bacterial infections.
28 rged as new tools that can be used to combat
deadly bacterial infections.
29 his pathway enhances host protection against
deadly bacterial infections.
30 tus as one of the world's most prevalent and
deadly bacterial pathogens, Mycobacterium tuberculosis (
31 of a vaccine against a rapidly progressing,
deadly bacterium.
32 argeted and destroyed two different types of
deadly brain cancer, including glioblastoma and melanoma
33 glioblastoma (GBM), are the most common and
deadly brain cancers in adults.
34 alyze to investigate proteins altered in the
deadly brain tumor glioblastoma.
35 toma multiforme (GBM) is the most common and
deadly brain tumor in adults.
36 Glioblastoma multiforme (GBM) is the most
deadly brain tumor, and currently lacks effective treatm
37 Glioblastomas (GBM),
deadly brain tumors, have greater incidence in males tha
38 Hits in deeper water were more
deadly,
but less frequent, so mortality decreased with d
39 MERS-CoV is
deadly,
but this work shows that its clinical severity d
40 tocellular carcinoma (HCC) is the third most
deadly cancer in the US, with a meager 5-year survival r
41 Pancreatic ductal adenocarcinoma (PDAC) is a
deadly cancer in which NF-kappaB pathways promote biolog
42 Pancreatic ductal adenocarcinoma (PDA) is a
deadly cancer that resists efforts to identify better ch
43 Nowadays, it is the world's fourth most
deadly cancer with almost 900 000 deaths annually.
44 Esophageal adenocarcinoma is a
deadly cancer with increasing incidence in the United St
45 Glioblastoma multiforme (GBM), a
deadly cancer, is the most lethal and common malignant b
46 Glioblastoma is a
deadly cancer, with no effective therapies.
47 stasis, precluding timely management of this
deadly cancer.
48 (PDAC) and cholangiocarcinoma (CCA) are both
deadly cancers and they share many biological features b
49 ocellular carcinoma (HCC) is one of the most
deadly cancers that still lacks effective treatments.
50 reatment, and survival among the top 10 most
deadly cancers using the SEER database.
51 to current and future patients for the most
deadly cancers, and that a less conservative alpha may b
52 infections lead to cervical cancer or other
deadly cancers.
53 rol of inflammatory responses to prevent the
deadly cardiac pathology in human Chagas disease is a de
54 a garganica (dicot, Apiaceae), also known as
deadly carrot, produces the highly toxic compound thapsi
55 Idiopathic pulmonary fibrosis (IPF) is a
deadly chronic lung disease.
56 Huanglongbing (HLB) is a worldwide
deadly citrus disease caused by the phloem-limited bacte
57 quence type (ST) 131, harbors both MDR and a
deadly complement of virulence factors.
58 ss that underlies the process of fibrosis, a
deadly complication of fibrotic diseases like scleroderm
59 Bleeding esophageal varices is a
deadly complication of liver cirrhosis.
60 The most
deadly complication of Plasmodium falciparum infection i
61 (GVHD) after liver transplantation (LT) is a
deadly complication with very limited data on risk facto
62 ncer cachexia remains a largely intractable,
deadly condition for patients with no approved, effectiv
63 ed hepatic artery pseudoaneurysm stands as a
deadly condition which has to be diagnosed and managed a
64 oV-2 and the viruses behind the two previous
deadly coronavirus outbreaks, SARS-CoV and Middle East r
65 ry arterial hypertension (PAH) is a rare and
deadly disease affecting roughly 15-60 people per millio
66 nse, a recalcitrant parasite that causes the
deadly disease African sleeping sickness.
67 hese risks is urgently needed to combat this
deadly disease and prevent future TB epidemics.
68 esophageal squamous cell carcinoma (ESCC), a
deadly disease associated with dietary Zn deficiency and
69 Naegleria fowleri causes an uncommon but
deadly disease called primary amoebic meningoencephaliti
70 Idiopathic pulmonary fibrosis is a
deadly disease characterized by excessive extracellular
71 ntine hemorrhagic fever (AHF), a potentially
deadly disease endemic to central regions of Argentina.
72 Lung squamous cell carcinoma (SCC) is a
deadly disease for which current treatments are inadequa
73 ch settings, Burkitt lymphoma (BL) remains a
deadly disease in older patients and in sub-Saharan Afri
74 olutionized the treatment of AIDS, turning a
deadly disease into a manageable chronic condition.
75 Pierce's disease (PD) is a
deadly disease of grapevines caused by the Gram-negative
76 Ovarian cancer is a
deadly disease that afflicts ~22,000 women per year in t
77 y progress to visceral leishmaniasis (VL), a
deadly disease that threatens 200 million people in area
78 hanged the prognosis of HIV infection from a
deadly disease to a chronic disease.
79 Oesophageal squamous cell carcinoma is a
deadly disease where systemic therapy has relied upon em
80 nd provide a new therapeutic target for this
deadly disease with high translational potential.
81 le: Idiopathic pulmonary fibrosis (IPF) is a
deadly disease with increasingly impaired health-related
82 Malignant mesothelioma is a
deadly disease with limited therapeutic options.
83 Heart failure (HF) is a prevalent and
deadly disease, and preventive strategies focused on at-
84 Although PADC remains a
deadly disease, long-term survival is possible, even bey
85 promoting key features associated with this
deadly disease, proliferation on one hand and invasion o
86 Esophageal cancer is a
deadly disease, ranking sixth among all cancers in morta
87 mechanisms driving tumor progression in this
deadly disease.
88 f the viral genetic factors involved in this
deadly disease.
89 its promise as a therapeutic target for this
deadly disease.
90 evelopment of novel approaches to fight this
deadly disease.
91 new point to broadly address this widespread
deadly disease.
92 vides alternative treatment options for this
deadly disease.
93 Metastatic melanoma is an aggressive and
deadly disease.
94 may provide therapeutic strategies for this
deadly disease.
95 tter understand the biologic process in this
deadly disease.
96 a novel therapeutic strategy to combat this
deadly disease.
97 alternate treatment options to prevent this
deadly disease.
98 targeted diagnostics and therapies for this
deadly disease.
99 novel therapeutic strategies to combat this
deadly disease.
100 imit the growing indirect toll of an already
deadly disease.
101 herapeutic strategies for patients with this
deadly disease.
102 be an effective treatment strategy for this
deadly disease.
103 nding of the molecular underpinnings of this
deadly disease.
104 ycin for the treatment of this disabling and
deadly disease.
105 e arsenal of therapeutics for this extremely
deadly disease.
106 pening new avenues for the treatment of this
deadly disease.FUNDINGThis research was supported by the
107 There is no cure or treatment for this
deadly disease; therefore there is an urgent need to dev
108 is important for early intervention to treat
deadly diseases and provide possible targets to cure the
109 loping vaccines for some of the world's most
deadly diseases, including AIDS and malaria.
110 the early and inexpensive detection of these
deadly diseases.
111 or treatment and prevention of both of these
deadly diseases.
112 ely necessary to improve outcomes from these
deadly diseases.
113 of three enzymes that can bypass potentially
deadly DNA lesions on the template strand during DNA rep
114 omplete protection of nonhuman primates from
deadly Ebola virus disease, even when treatment was begu
115 Nipah virus (NiV) is a
deadly emerging enveloped paramyxovirus that primarily t
116 ng effective therapeutics for treating these
deadly emerging pathogens.
117 rus is an emergent paramyxovirus that causes
deadly encephalitis and respiratory infections in humans
118 ipura virus (CHAV), which is responsible for
deadly encephalopathies.
119 ysins, but how penicillins misactivate these
deadly enzymes has long remained unclear.
120 ks of fatal infections, including the recent
deadly epidemic in West Africa.
121 In 2006, a
deadly Escherichia coli O157:H7 outbreak in bagged spina
122 hem to withstand or recover from potentially
deadly events.
123 ting gluconeogenesis may help eradicate this
deadly feature in advanced breast cancer patients.
124 ed may present a novel opportunity to target
deadly fibrotic diseases.
125 ies, we identified the matrix protein of the
deadly fish novirhabdovirus VHSV as a critical mediator
126 To protect consumers from
deadly foodborne E. coli O157:H7 infection, it is vital
127 rotfish, turning normal trophic interactions
deadly for corals.
128 in cancer, which further metastasizes into a
deadly form of cancer.
129 es and provide diagnostic potential for this
deadly form of cancer.
130 Subarachnoid haemorrhage, a particularly
deadly form of intracranial haemorrhage, shares key path
131 In the causative parasite of the most
deadly form of malaria in humans, Plasmodium falciparum,
132 The most common and
deadly form of primary brain cancer, glioblastoma (GBM),
133 and relapse in glioblastoma (GBM), the most
deadly form of primary brain cancer.
134 Melanoma is the most
deadly form of skin cancer with a yearly global incidenc
135 in defence against pathogens, including the
deadly fungal pathogen Batrachochytrium dendrobatidis (B
136 Cryptococcus neoformans (Cn) is a
deadly fungal pathogen whose intracellular lifestyle is
137 y to optimize host immune responses toward a
deadly fungal pathogen.
138 regulation of the key virulence factor of a
deadly fungus-its capsule.
139 rical signals and are frequently targeted by
deadly gating-modifier neurotoxins, including tarantula
140 Cystic fibrosis (CF), a most
deadly genetic disorder, is caused by mutations of CF tr
141 3 genes (H3K27M) characterize a subgroup of
deadly gliomas and decrease genome-wide H3K27 trimethyla
142 to arginine/valine (G34R/V) mutations drive
deadly gliomas and show exquisite regional and temporal
143 Epithelial ovarian cancer (EOC) is the most
deadly gynaecologic malignancy due to late onset of symp
144 Ovarian cancer is a
deadly gynecologic malignancy for which novel biomarkers
145 as a low incidence rate, it remains the most
deadly gynecologic malignancy.
146 Ovarian cancer (OC) is the most
deadly gynecological cancer and unlike most other neopla
147 xposing more than 350 million more people to
deadly heat by 2050 under a midrange population growth s
148 o help interpret the increasing frequency of
deadly heat under specified amounts of global warming.
149 Acute myeloid leukemia (AML) is a
deadly hematologic malignancy characterized by the uncon
150 Acute myeloid leukemia (AML) is a
deadly hematologic malignancy with poor prognosis, parti
151 o, and Machupo viruses, can cause severe and
deadly hemorrhagic fever diseases in humans, and there a
152 nly limited therapeutic options to treat the
deadly hemorrhagic fever diseases they cause.
153 Several mammarenaviruses can cause
deadly hemorrhagic fever infections in humans, with limi
154 Ebolavirus, a
deadly hemorrhagic fever virus, was thought to enter cel
155 es, mumps, and parainfluenza viruses and the
deadly henipaviruses Nipah (NiV) and Hendra (HeV) viruse
156 Tsetse flies are the cyclical vectors of
deadly human and animal trypanosomes in sub-Saharan Afri
157 et for the development of antivirals against
deadly human arenavirus pathogens.
158 Hepatocellular carcinoma (HCC) is a
deadly human cancer associated with chronic inflammation
159 toxicity are urgently needed to combat this
deadly human disease.
160 ss-beta amyloid core and are associated with
deadly human diseases.
161 al pathogens that are the causative agent of
deadly human infections.
162 physiopathology of malaria, one of the most
deadly human parasitic diseases worldwide, is complex, a
163 capacity of the nucleosome landscape in this
deadly human pathogen.
164 Filoviruses are among the most
deadly human pathogens.
165 irus that causes rabies (RABV), include many
deadly human pathogens.
166 ococcosis (AE) is a zoonotic disease that is
deadly if left untreated.
167 Visceral leishmaniasis is a
deadly illness caused by Leishmania donovani that provok
168 HeV) is a zoonotic paramyxovirus that causes
deadly illness in horses and humans.
169 L1), a mammalian CLR, in pneumonic sepsis, a
deadly immune disorder frequently associated with a nonr
170 Invasive aspergillosis is a
deadly infection for which new antifungal therapies are
171 istidine, causes scrub typhus, a potentially
deadly infection that threatens 1 billion people.
172 by host cells and in host resistance to this
deadly infection.
173 may participate in the pathogenicity of this
deadly infection.
174 ssure that the vaccine protects against this
deadly infection.
175 management of this uncommon but potentially
deadly infection.
176 Henipaviruses cause
deadly infections in humans, with a mortality rate of ab
177 machinery.IMPORTANCE Henipaviruses can cause
deadly infections of medical, veterinary, and agricultur
178 WHO and is responsible for severe and often
deadly infections such as bloodstream infections and pne
179 Malaria is a
deadly infectious disease caused by parasites of the Pla
180 Tuberculosis is currently the single most
deadly infectious disease in the world and a public heal
181 Plasmodium falciparum malaria is a
deadly infectious disease in which Abs play a critical r
182 Tuberculosis (TB) is a
deadly infectious disease, which kills millions of peopl
183 uberculosis is the cause of the world's most
deadly infectious disease.
184 Malaria remains one of the most
deadly infectious diseases, causing hundreds of thousand
185 Rabies is one of the most
deadly infectious diseases, with a case-fatality rate ap
186 of laterally extensive sills as the critical
deadly interval.
187 o switch from a soil dwelling bacterium to a
deadly intracellular pathogen.
188 ans, it is responsible for cryptococcosis, a
deadly invasive fungal infection that represents around
189 opportunistic human pathogen responsible for
deadly,
invasive infections in immunocompromised patient
190 ed in various diseases, among which the most
deadly is glioblastoma multiforme (GBM).
191 enal medullary carcinoma (RMC) is a rare and
deadly kidney cancer in patients of African descent with
192 t the molecular and clinical features of the
deadly LCNEC, further supporting the previously proposed
193 ovel therapeutic target for the treatment of
deadly lung adenocarcinomas.
194 ell lung carcinoma, SCLC) are among the most
deadly lung cancer conditions with no optimal clinical m
195 Marek's disease virus (MDV) causes
deadly lymphoma and induces an imbalance of the lipid me
196 s (MDV), an avian alphaherpesvirus, causes a
deadly lymphoma in chickens and hijacks host cell metabo
197 a T(reg) signature, ultimately resulting in
deadly lymphomas.
198 Marek's disease virus (MDV) causes a
deadly lymphoproliferative disease in chickens and modul
199 Basal subtype cancers are
deadly malignancies but the molecular events driving tum
200 igh-grade serous ovarian cancers (HGSCs) are
deadly malignancies that relapse despite carboplatin che
201 Bladder cancer is a common and
deadly malignancy but its treatment has advanced little
202 Pancreatic cancer is a
deadly malignancy that lacks effective therapeutics.
203 l system to discover characteristics of this
deadly malignancy.
204 Hepatocellular carcinoma (HCC) is a most
deadly malignant disease worldwide, with no effective me
205 istant sites in the body represents the most
deadly manifestation of cancer.
206 ercion do not exhaust the causal pathways to
deadly martyrdom.
207 conjugate vaccine was developed to eliminate
deadly meningitis epidemics in sub-Saharan Africa.
208 mals, such as camels, as well as humans from
deadly MERS-CoV and RABV infections.
209 al targets for disrupting formation of these
deadly metastatic seeds.
210 The growing prevalence of
deadly microbes with resistance to previously life-savin
211 A
deadly mouse pathogen, PVM has the potential to serve as
212 eristic lymph node histopathology, and often
deadly multiple organ dysfunction.
213 Duchenne muscular dystrophy is a
deadly muscle-wasting disorder caused by loss of dystrop
214 mortality rate was 14.9%.CONCLUSIONGiven the
deadly nature of COVID-19 and the large population of cr
215 and known as one of the most devastating and
deadly neoplasms.
216 (MDV) transforms CD4(+) T cells and causes a
deadly neoplastic disease that is associated with metabo
217 ential inhibitor scaffold for preventing the
deadly neurochemical effects of the toxin.
218 Merkel cell carcinoma (MCC) is a rare and
deadly neuroendocrine skin tumor frequently associated w
219 ins (BoNTs) form a large class of potent and
deadly neurotoxins.
220 We used the
deadly Nipah virus (NiV) as an important paramyxoviral m
221 osafety level 4 (BSL4) pathogens such as the
deadly Nipah virus (NiV), virus-cell fusion mechanistic
222 Pancreatic ductal adenocarcinomas (PDAC) are
deadly on account of the delay in diagnosis and dearth o
223 , have been responsible for some of the most
deadly outbreaks in recent history.
224 these viruses into human populations causes
deadly outbreaks.
225 Cerebral malaria is a
deadly outcome of infection by Plasmodium falciparum, oc
226 Although rare in incidence, they are
deadly owing to slow growth and a lack of effective ther
227 iffuse Intrinsic Pontine Gliomas (DIPGs) are
deadly paediatric brain tumours where needle biopsies he
228 f pancreatic ductal adenocarcinoma (PDAC), a
deadly pancreatic neoplasm.
229 ment glycoprotein G of Hendra virus (HeV), a
deadly paramyxovirus, is N-glycosylated at six sites (G2
230 echanisms regulating gene expression in this
deadly parasite.
231 ges have specialized as pathogens, including
deadly parasites of insects that are used in biological
232 understanding of why certain strains of this
deadly pathogen have spread rapidly throughout the world
233 Intracellular replication of the
deadly pathogen Mycobacterium tuberculosis relies on the
234 ion of Ail, the major surface protein of the
deadly pathogen Yersinia pestis.
235 ptococcus pyogenes, a common and potentially
deadly pathogen, many sRNAs have been identified, but on
236 oteome (NTPome) in M. tuberculosis (M.tb), a
deadly pathogen.
237 sion can enhance the lethality of an already
deadly pathogen.
238 able insights into the pathogenicity of this
deadly pathogen.
239 stitute an effective immune response to this
deadly pathogen.
240 cious vaccines and therapeutics against this
deadly pathogen.
241 an important role in the replication of this
deadly pathogen.IMPORTANCE Disturbances of the lipid met
242 t skeletal sites, but factors mediating this
deadly pathogenic advance remain poorly understood.
243 ure to defend themselves against potentially
deadly pathogens and herbivores.
244 Since the emergence of
deadly pathogens and multidrug-resistant bacteria at an
245 izing interest in the mechanics of how these
deadly pathogens move.
246 nd Nipah virus (NiV) are reportedly the most
deadly pathogens within the Paramyxoviridae family.
247 aining this essential nutrient they transmit
deadly pathogens.
248 es used to halt the striking spread of these
deadly pathogens.
249 Abdominal aortic aneurysms (AAAs) are a
deadly pathology with strong sexual dimorphism.
250 gets, MDM2 and MDM4, as vulnerabilities in a
deadly pediatric cancer and provides preclinical evidenc
251 Neuroblastoma is a
deadly pediatric solid tumor with infrequent recurrent s
252 Malignant rhabdoid tumors (MRT) are rare but
deadly pediatric tumors characterized by mutations in th
253 virus) has been declared most widely spread
deadly persistent epidemic due to unavailability of rapi
254 tract infections in humans and outbreaks of
deadly pneumonia worldwide.
255 past few decades by two global outbreaks of
deadly pneumonia.
256 otherwise noninvasive S. pneumoniae to cause
deadly pneumonia.
257 Cancer stem cells sustain propagation of the
deadly primary brain cancer glioblastoma.
258 g a powerful form of host resistance against
deadly primate lentiviruses.
259 he second maxima occurred near the time of a
deadly pyroclastic density current (PDC) and thunderstor
260 or that detects and responds to infection by
deadly RNA viruses such as influenza, and Hepatitis C.
261 M(pro)s from other human CoVs (including the
deadly SARS-CoV and MERS-CoV) and their related zoonotic
262 able general anesthetics produce potentially
deadly side effects.
263 Osteogenic sarcoma (OS) is a
deadly skeletal malignancy whose cause is unknown.
264 ates with progression of synovial sarcoma, a
deadly soft tissue malignancy initiated by a t(X;18) chr
265 Alveolar soft part sarcoma (ASPS), a
deadly soft tissue malignancy with a predilection for ad
266 Cancer metastasis is the most
deadly stage in cancer progression.
267 tery occlusion is one of the most common and
deadly sterile injuries in developed countries.
268 ho carried out the most deadly and the least
deadly strikes.
269 plant toxins to defend themselves against a
deadly symbiosis between the third and the fourth trophi
270 syndrome), and male biological sex produce a
deadly symbiosis of dysregulated immunometabolism and ch
271 The
deadly symptoms of malaria occur as Plasmodium parasites
272 Sepsis is a common and
deadly syndrome in which a dysregulated host response to
273 rus (MDV) is an alphaherpesvirus that causes
deadly T-cell lymphomas in chickens and serves as a natu
274 rring most often in childhood, is a rare but
deadly thrombomicroangiopathy called atypical hemolytic
275 The world's most catastrophic and
deadly thunderstorm asthma epidemic struck Melbourne, Au
276 cellular and molecular functions and may be
deadly to phagocytic cells, which may result in increase
277 gically controlled amounts yet paradoxically
deadly to the CNS when in excess.
278 num neurotoxin A (BoNT/A) is one of the most
deadly toxins and is the etiological agent of the potent
279 and reagents, allowing for fast detection of
deadly toxins with high clinical relevance.
280 phosphate and cyanobacteria known to produce
deadly toxins.
281 the neural crest and is the most common and
deadly tumor of infancy.
282 , our results open novel research avenues in
deadly tumors.
283 a potential novel targeted therapy for these
deadly tumors.
284 een linked to pulmonary hypertension (PH), a
deadly vascular disease with poorly defined molecular or
285 female-specific blood-feeding behavior in a
deadly vector of infectious diseases.
286 visceral leishmaniasis (VL), the second most
deadly vector-borne parasitic disease.
287 Female Aedes aegypti mosquitoes are
deadly vectors of arboviral pathogens and breed in conta
288 on brunoi) are more toxic than the venoms of
deadly venomous Brazilian pitvipers, genus Bothrops; C.
289 ges associated with the early spread of this
deadly virus.
290 are being adapted for the detection of this
deadly virus.
291 ssion and immune evasion strategies of these
deadly viruses may guide the development of novel preven
292 The emergent
deadly viruses Nipah virus (NiV) and Hendra virus belong
293 ses, are a class of pathogenic and sometimes
deadly viruses that include rabies virus (RABV), human r
294 rect-acting antivirals (DAAs) to combat such
deadly viruses.
295 uld be developed as antivirals against these
deadly viruses.
296 arsenal of proteins that protect us against
deadly viruses.
297 f seven serotypes with BoNT/A being the most
deadly;
yet, there is no approved therapeutic for their
298 B virus (Macacine herpesvirus 1) can cause
deadly zoonotic disease in humans.
299 cytial virus, human metapneumovirus, and the
deadly zoonotic henipaviruses Hendra and Nipah virus (Ni
300 Nipah virus (NiV) is a highly pathogenic and
deadly zoonotic paramyxovirus.