ライフサイエンスコーパス: deaminase

1 lved in dNTP biosynthesis (e.g., RNR or dCMP deaminase).

2 , by directly evolving ADAR2 into a cytidine deaminase.

3 tivation of a previously nonfunctional d-Ser deaminase.

4 ctive BLM and the downregulation of cytidine deaminase.

5 s are damaged by activation-induced cytidine deaminase.

6 ells mediated by activation-induced cytidine deaminase.

7 he extracellular space by secreted adenosine deaminase.

8 fusing SauriCas9 to the cytidine and adenine deaminase.

9 ompared with other zinc-dependent nucleotide deaminases.

10 catalytic polypeptide-like (APOBEC) cytidine deaminases.

11 ion polymerase, and the APOBEC family of DNA deaminases.

12 editing by both rAPOBEC1 and PmCDA1 cytidine deaminases.

13 that possesses high density of Mycobacterium deaminases.

14 with lineage-specific expression of cytidine deaminases.

15 host antiviral factors, the APOBEC3 cytidine deaminases.

16 Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal-recessive l

17 Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious m

18 ation of anaplerotic reactions driven by AMP deaminase 3 (Ampd3) and catabolism of branched-chain ami

19 R-loops limit activation-induced (cytosine) deaminase access to the transcribed DNA strand.

20 ure and the temporal expression of adenosine deaminase acting on RNA (ADAR) contribute to cis- and tr

21 deaminase-deficient member of the adenosine deaminase acting on RNA (ADAR) family, is competing with

22 and filamentous fungi do not have adenosine deaminase acting on RNA (ADAR) orthologs and are believe

23 talytically inactive member of the Adenosine Deaminase Acting on RNA (ADAR) protein family, whose act

24 nflammation-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene, occurs in 30-50% o

25 Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible for adenosi

26 we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (ADAR2) that deaminates A to ino

27 the Zalpha-binding domain of human adenosine deaminase acting on RNA 1 (ADAR1, hZalphaADAR1), as conf

28 inhibits editing, we do show that adenosine deaminase acting on RNA 1 and 2 and fibrillarin negative

29 kdown demonstrated that editing is adenosine deaminase acting on RNA 1 and 2 dependent.

30 osine deaminase activity by ADAR2 (adenosine deaminase acting on RNA type 2) to transcripts in mammal

31 zymes or of endogenous human ADAR (adenosine deaminase acting on RNA) enzymes.

32 to-inosine RNA editing mediated by adenosine deaminase acting on RNA1 (ADAR1) promotes cancer progres

33 al elements are silenced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] togeth

34 (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR),

35 RNA editing by adenosine deaminases acting on dsRNA (ADAR) has become of increasi

36 catalyzed by a family of enzymes, adenosine deaminases acting on dsRNA (ADARs).

37 ence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated

38 Adenosine deaminases acting on RNA (ADARs) are enzymes that conver

39 Adenosine deaminases acting on RNA (ADARs) catalyze the editing of

40 Adenosine deaminases acting on RNA (ADARs) convert adenosine to in

41 Adenosine deaminases acting on RNA (ADARs) convert adenosines to i

42 inase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and

43 deaminase activity and what are the relative deaminase activities for each APOBEC member remain uncle

44 that Vif binds and inhibits the non-cytosine deaminase activities of intact A3G and intact A3F, allow

45 Here, we performed a family-wide analysis of deaminase activities on C and mC by using purified recom

46 A3A and A3H showed distinctively high deaminase activities on C and mC with relatively high se

47 al signature analyses pointed towards APOBEC deaminase activity (COSMIC signature 2) and DNA mismatch

48 x other APOBEC members showed relatively low deaminase activity and selectivity for mC.

49 nalyses revealed that each APOBEC has unique deaminase activity and selectivity for mC.

50 at loop-1 of A3A is responsible for its high deaminase activity and selectivity for mC.

51 ether the rest of APOBEC members have any mC deaminase activity and what are the relative deaminase a

52 as13 (dCas13) to direct adenosine-to-inosine deaminase activity by ADAR2 (adenosine deaminase acting

53 ngs, the Y315A mutant exhibited little to no deaminase activity in an Escherichia coli DNA mutator re

54 causing elevated A3B expression and cytosine deaminase activity in cancer cells.

55 e dissociation from DNA is reduced and their deaminase activity inhibited.

56 or CDK4-Cyclin D1 phosphorylation nor is its deaminase activity modulated.

57 enome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzy

58 r each individual domain, as well as for the deaminase activity of CD2 domain in the full-length A3F.

59 te a simple method for assaying DNA cytosine deaminase activity that eliminates potential polymerase

60 ng through DYW2, which probably provides the deaminase activity to E(+) editosomes.

61 editing if they contain cytosines within the deaminase activity window.

62 CBEs to illuminate the relationship between deaminase activity, base editing efficiency, editing win

63 c deaminase APOBEC3A leads to elevated ssDNA deaminase activity, likely by facilitating opening of th

64 057c/UK114 protein family have imine/enamine deaminase activity, notably on 2-aminoacrylate (2AA).

65 dividuals display a severe reduction in tRNA deaminase activity.

66 hiometrically inhibits APOBEC3B DNA cytosine deaminase activity.

67 in, and RNase A treatment enables strong DNA deaminase activity.

68 icant, but not sole, factor in resistance to deaminase activity.

69 , despite the bound RNA, has potent cytidine deaminase activity.

70 expression and concomitant cellular cytosine deaminase activity.

71 RNA modification, is regulated by adenosine deaminase (AD) domain containing proteins.

72 ly gene array analysis identifying adenosine deaminase (ADA) as a key molecule that delineates a huma

73 Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined immun

74 Adenosine deaminase (ADA) deficiency results in the accumulation o

75 by gammac-deficiency (SCID X1) and adenosine deaminase (ADA) deficiency.

76 Three days later, an adenosine deaminase (ADA) level of 118.1 U/L (normal range, 0.0-11

77 Adenosine deaminase (ADA), IRISA-TB (interferon gamma ultrasensiti

78 f a selective covalent modifier of adenosine deaminase (ADA).

79 MS2 binding sites that recruit the adenosine deaminase ADAR2 fused to an MS2 capsid protein.

80 rucei m(3)C methyltransferase TRM140 and the deaminase ADAT2/3.

81 Unlike for bacterial cytidine deaminase, addition of two putative transition-state ana

82 between EBV and activation-induced cytidine deaminase (AICDA) activity.

83 y evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzyme APOBEC1 (A1

84 ine four main patterns of activation-induced deaminase (AID) and apolipoprotein B mRNA editing cataly

85 Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme

86 Igh locus in an activation-induced cytidine deaminase (AID) and H2AX-dependent fashion.

87 is initiated by activation-induced cytidine deaminase (AID) and requires base excision repair (BER)

88 ve reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (TET) famil

89 he activities of activation-induced-cytidine deaminase (AID) and the A-T mutator, DNA polymerase eta,

90 onal deletion of activation-induced cytidine deaminase (AID) between heterologous challenges of West

91 Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiat

92 Activation-induced cytidine deaminase (AID) generates U:G mismatches in Ig genes tha

93 Endogenous activation-induced cytidine deaminase (AID) in engineered cells allowed for Ig class

94 Activation-induced cytidine deaminase (AID) initiates both class switch recombinatio

95 Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) class swit

96 Activation-induced deoxycytidine deaminase (AID) initiates somatic hypermutation (SHM) in

97 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and clas

98 Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets

99 Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme that initiat

100 Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunog

101 se CTNNBL1 binds activation-induced cytidine deaminase (AID) that catalyzes SHM, we tested AID intera

102 E. coli, we used activation-induced cytidine deaminase (AID) to construct AID-nCas9-Ung and found tha

103 s, we used human activation-induced cytidine deaminase (AID) to identify genes preventing R loops.

104 d recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions).

105 ise targeting of activation-induced cytidine deaminase (AID) to immunoglobulin (Ig) loci promotes ant

106 ctivators induce activation-induced cytidine deaminase (AID)(2) and I-promoter transcription, with 3'

107 is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA doub

108 diversity is initiated by activation-induced deaminase (AID), which deaminates cytosine to uracil in

109 A-editing enzyme activation-induced cytidine deaminase (AID), which is required in affinity maturatio

110 introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand breaks into

111 having undergone activation-induced cytidine deaminase (AID)-mediated somatic hypermutation (SHM) fol

112 ivity of the DNA activation-induced cytidine deaminase (AID).

113 he expression of activation-induced cytosine deaminase (AID).

114 ent induction of activation-induced cytidine deaminase (AID).

115 -Cas9 to disrupt activation-induced cytidine deaminase (AID; Aicda) directly in BXSB zygotes.

116 ugh induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precursor B-cell

117 zymes in the biosynthetic network: threonine deaminase (also named l-O-methylthreonine resistant 1 [O

118 in of function in adenosine 5'-monophosphate deaminase (AMPD3).

119 (GBEs) consist of a Cas9 nickase, a cytidine deaminase and a uracil-DNA glycosylase (Ung).

120 Adenosine deaminase and IRISA-TB sensitivity were 84.4% (73.9 to 9

121 ynthetic lethal interaction between cytidine deaminase and microtubule-associated protein Tau deficie

122 kappaB to induce activation-induced cytidine deaminase and, therefore, Ig class switch DNA recombinat

123 Here we engineered programmable cytidine deaminases and test if we could introduce site-specific

124 tive Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair.

125 ydrogenase, nucleoside hydrolases, guanosine deaminase, and hypoxanthine guanine phosphoribosyltransf

126 e B-cell mutagenic enzyme activation-induced deaminase, and immune evasion through major histocompati

127 lytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated dNTP trip

128 mutation signature associated with cytidine deaminase APOBEC, which correlates with the upregulation

129 In DART-seq, the cytidine deaminase APOBEC1 is fused to the m(6)A-binding YTH doma

130 based on a mitochondrially-targeted cytidine deaminase, APOBEC1.

131 loop 1 to mimic the more potent cytoplasmic deaminase APOBEC3A leads to elevated ssDNA deaminase act

132 The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataeg

133 The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C) to urac

134 Here, we show that the related cytidine deaminase, APOBEC3G, induces site-specific C-to-U RNA ed

135 ns introduced by activation-induced cytidine deaminase are processed by multiple error-prone repair p

136 ls introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG)

137 embers of the APOBEC3 family of DNA cytosine deaminases are capable of inhibiting HIV-1 replication b

138 APOBEC3 cytidine deaminases are largely known for their innate immune pro

139 and homologous single-stranded DNA cytosine deaminases are unique to mammals.

140 Previous studies identified APOBEC deaminases as enzymes targeting hepatitis B virus (HBV)

141 Adenosine deaminase associated with RNA1 (ADAR1) deregulation cont

142 ell populations that have been modified with deaminase base editing technologies are inefficient and

143 CBE(7), and the Petromyzon marinus cytidine deaminase-based CBE Target-AID(4) induce less editing of

144 ed CBE(6), human activation-induced cytidine deaminase-based CBE(7), and the Petromyzon marinus cytid

145 The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses vi

146 quires the activity of two enzymes: cytosine deaminase (CD) and UPRT.

147 EC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions

148 Flura-seq utilizes cytosine deaminase (CD) to convert fluorocytosine to fluorouracil

149 ibilities for anti-cancer treatment.Cytidine deaminase (CDA) deficiency leads to genome instability.

150 lable because of rapid clearance by cytidine deaminase (CDA) in the gut and liver.

151 tetrahydrouridine (THU) to inhibit cytidine deaminase (CDA), the enzyme that otherwise rapidly deami

152 he pyrimidine metabolic pathway and cytidine deaminase (CDA).

153 to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids.

154 ong isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria.

155 related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucl

156 We evolved the deaminase component of ABE7.10 using phage-assisted non-

157 limited compatibility of the deoxyadenosine deaminase component with Cas homologs other than SpCas9.

158 MPORTANCE The APOBEC3 family of DNA cytosine deaminases constitutes a vital innate immune defense aga

159 Bypassing metabolically the adenosine deaminase defect by inosine supplementation was benefici

160 mbined immune deficiency caused by adenosine deaminase defects (ADA-SCID).

161 hat has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SCID when combined w

162 genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitutive DNA d

163 Tau is overexpressed in cytidine deaminase-deficient cells, and its depletion worsens gen

164 unctions in maintaining survival of cytidine deaminase-deficient cells, and ribosomal DNA transcripti

165 Biochemical data suggest that ADR-1, a deaminase-deficient member of the adenosine deaminase ac

166 In dramatic contrast, 39 adenosine deaminase-deficient severe combined immunodeficiency (AD

167 tors that inhibit HIV-1 through DNA cytidine deaminase-dependent and -independent mechanisms and have

168 be sufficient to competitively inhibit ssDNA deaminase-dependent antiviral activity.

169 Signatures of APOBEC cytidine deaminase DNA-editing exhibited substantial fluctuations

170 of a fragment of human ADAR2 comprising its deaminase domain and double stranded RNA binding domain

171 ating ssDNA interaction with or entry to the deaminase domain and hypothesize that RNA bound to Tyr-3

172 ported crystal structures of the human ADAR2 deaminase domain bound to duplex RNA revealing a protein

173 Mutations that weaken the deaminase domain can minimize the undesirable effects, b

174 BE8e in a substrate-bound state in which the deaminase domain engages DNA exposed within the CRISPR-C

175 art editor REPAIR, which comprises the ADAR2 deaminase domain fused to dCas13b.

176 lternative Cas protein (CasRx), inserted the deaminase domain into the middle of CasRx, and redirecte

177 eting CRISPR-Cas13 (dCas13) with the adenine deaminase domain of ADAR2.

178 inc-binding site on the surface of the ADAR1 deaminase domain which is important for ADAR1 editing ac

179 ent with full length ADAR2 than its isolated deaminase domain.

180 ers, variants were situated in or around the deaminase domain.

181 DYW-deaminase domains act as the editing enzyme.

182 ubstrates are deaminated efficiently by ADAR deaminase domains at dA-C mismatches and with E to Q mut

183 red base editors containing mutated cytidine deaminase domains that narrow the width of the editing w

184 mitrella patens) PPR proteins containing DYW-deaminase domains, PPR65 and PPR56, can convert Cs to Us

185 APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress an

186 es are the seven human APOBEC3 deoxycytidine deaminases, each with unique target sequence specificity

187 ive OSCCs, the signatures of APOBEC cytosine deaminase editing, associated with anti-viral immunity,

188 uctivity, but increased the abundance of ACC deaminase-encoding gene (acdS), enhanced soil microbial

189 CURE comprises the cytidine deaminase enzyme APOBEC3A fused to dCas13 and acts in co

190 Several adenosine or cytidine deaminase enzymes deaminate transcript sequences in a ce

191 d characterize the RNA off-target effects of deaminase enzymes in base editor platforms.

192 Another evolved deaminase, evoFERNY, is 29% smaller than APOBEC1 and edi

193 Adenine base editors comprise an adenosine deaminase, evolved in vitro, and a Cas9 nickase.

194 vivo by altering activation-induced cytidine deaminase expression.

195 Deletion of yeast cytosine deaminase Fcy1 significantly decreased the rate of CAG r

196 from the preference of APOBEC3A, a cytidine deaminase, for DNA stem-loops.

197 Ung excises the U base created by the deaminase, forming an apurinic/apyrimidinic (AP) site th

198 Using cytidine deaminase fused to Cas9 nickase, up to 28% of site-speci

199 mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase.

200 ablation of the activation-induced cytidine deaminase gene required for class switch recombination/s

201 o upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and T-indepe

202 equent deletion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased e

203 B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is

204 The APOBEC3 family of deoxycytidine deaminases has the ability to restrict HIV-1 through dea

205 striction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive selection and expansi

206 These deaminases have also been proposed to function in DNA de

207 was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and an intact

208 cations for the control of another mutagenic deaminase, human AID, and provides a rationale for its r

209 ch could be mimicked by inhibiting adenosine deaminase in control lines.

210 V485I, E527Q, Q549R and Q733D) engender RNA deaminase in human ADAR3.

211 genomes have implicated the APOBEC3 cytosine deaminases in oncogenesis, possibly offering a therapeut

212 dine, an inhibitor of cytidine/deoxycytidine deaminase, in patients with a variety of solid tumors un

213 evidence have revealed that APOBEC3 cytidine-deaminases, including human APOBEC3G (hA3G), can potentl

214 s the dominant mechanism of restriction, the deaminase-independent mechanism additionally contributes

215 ntial for A3H antiviral activity and for two deaminase-independent processes: encapsidation into vira

216 The activation-induced cytidine deaminase-induced DNA lesions and error-prone repair tha

217 B activation and activation-induced cytidine deaminase induction, and boosts IgG Ab and autoantibody

218 subunit 3C (APOBEC3C, a nucleic acid-editing deaminase), inherently restrict Zika virus infection.

219 Furthermore, adenosine deaminase inhibition in control induced astrocytes led t

220 e: (1) dT+dC and (2) coadministration of the deaminase inhibitor, tetrahydrouridine (THU), with dTMP+

221 e (APOBEC) proteins are a family of cytidine deaminases involved in various important biological proc

222 The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and pro

223 The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of

224 tein SLO2, which lacks a C-terminal cytidine deaminase-like DYW domain, interacts in vivo with the DY

225 ose that MTH1 acts in concert with adenosine deaminase-like protein isoform 1 (ADAL1) to prevent inco

226 Base editing by nucleotide deaminases linked to programmable DNA-binding proteins r

227 barrel proteins, targeting murine adenosine deaminase (mADA) that catalyzes the irreversible deamina

228 on with modulation of the level of adenosine deaminase may represent a beneficial therapeutic approac

229 The designed photocontrolled cytosine deaminases may also aid in improving chemotherapy approa

230 Here we investigate the fidelity of cytidine deaminase-mediated base editing in human induced pluripo

231 eficiency during activation-induced cytidine deaminase-mediated genomic instability.

232 Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational

233 BEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inacti

234 APOBEC cytidine deaminases mutate cancer genomes by converting cytidines

235 PfkB, but not PfkA), glucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk).

236 as12a) and nCas9-activation-induced cytidine deaminase (nCas9-Target-AID) systems to mutagenize Nicot

237 rand breakage at activation-induced cytidine deaminase off-target genes, its role at the hypermutatin

238 kely to bind this single-domain DNA cytosine deaminase on physically distinct surfaces.

239 Activation-induced cytidine deaminase, one of the APOBEC members, was reported to de

240 Because previously described cytidine deaminases operate on single-stranded nucleic acids(3),

241 t of wild-type mice with pegylated adenosine deaminase or CD73 antibodies also significantly reduced

242 We also tested CBEs with cytidine deaminases other than APOBEC1 and found that the human A

243 e, we report the discovery of a new class of deaminases, predominantly found in mycobacterial species

244 The activation-induced cytidine deaminase protein induces genome-wide DNA breaks that, i

245 mily of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and tr

246 ryotic orthologs additionally have adenosine deaminase, purine nucleoside phosphorylase, and S-methyl

247 Proteus vulgaris L-amino acid deaminase (pvLAAD) belongs to a class of bacterial membr

248 catalytic polypeptide-like (APOBEC) cytidine deaminases, raising questions about molecular mechanisms

249 rent base-editing platforms, including their deaminase recruitment strategies and editing outcomes, a

250 Interestingly, down-regulation of adenosine deaminase-related growth factor A (Adgf-A) from enterocy

251 de-like 3 (APOBEC3 or A3) family of cytidine deaminases restrict viral infections by mutating viral D

252 the broadly conserved reactive intermediate deaminase (Rid) (YjgF/YER057c/UK114) protein family, in

253 Reactive Intermediate Deaminase (Rid) protein superfamily includes eight famil

254 tranded RNA (dsRNA) editing enzyme adenosine deaminase RNA specific (ADAR), the RNase DICER1, and the

255 with altered CpGs and APOBEC-family cytosine deaminases similar to mutation signatures derived from s

256 up of predicted interbacterial toxins of the deaminase superfamily, members of which have found appli

257 In this study, we identify adenosine deaminase that acts on RNA 3 (ADAR3) as an important reg

258 In this work, we show that ADAR2 (adenosine deaminase that acts on RNA), an RNA editing enzyme, is e

259 potent substrate for APOBEC3A (A3A) cytidine deaminase that can promote formation of mutation cluster

260 G) is a single-stranded DNA (ssDNA) cytosine deaminase that can restrict HIV-1 infection by mutating

261 Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication.

262 Adenosine Deaminases that act on RNA (ADARs) are enzymes that cata

263 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (

264 ic subunit 3 (APOBEC-3) enzymes are cytidine deaminases that are broadly and constitutively expressed

265 ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA

266 t-diverged AID orthologs are active cytidine deaminases that exhibit unique substrate specificities a

267 AID / APOBEC genes are a family of cytidine deaminases that have evolved in vertebrates, and particu

268 tide 3 (APOBEC3) family members are cytidine deaminases that play important roles in intrinsic respon

269 BEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences against r

270 1, A2a, and A2b ADO receptors as well as ADO deaminase, the enzyme involved in ADO catabolism.

271 rely targeted by activation-induced cytidine deaminase, the enzyme responsible for antibody mutation.

272 a hybrid of a cytosine as well as a guanine deaminase, thereby conferring Msd the ability to expand

273 is likely conserved among all polynucleotide deaminases, thereby opening the door for the design of m

274 We used a Cas9 nickase (nCas9)-cytidine deaminase to conduct C to T editing of the Ethylene rece

275 s) are required to direct activation-induced deaminase to initiate class switching in B cells.

276 We evolved a transfer RNA adenosine deaminase to operate on DNA when fused to a catalyticall

277 e RNA allowing activation-induced (cytosine) deaminase to promote somatic hypermutation on both DNA s

278 se editing relies on recruitment of cytidine deaminases to introduce changes (rather than double-stra

279 ncer tissues presenting concomitant cytidine deaminase underexpression and Tau upregulation open up n

280 gle bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltransferase (FCU).

281 motifs as activity hotspots of the cytidine deaminase used.

282 lycosylase (eUNG) and a rat APOBEC1 cytidine deaminase variant (R33A) previously shown to have reduce

283 evolve ABE7.10 using a library of adenosine deaminase variants to create ABE8s.

284 APOBEC1 cytosine deaminase was initially characterized as pairing with a

285 OBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an Escherichia coli strain d

286 therapeutically useful enzyme yeast cytosine deaminase, we obtained a approximately 3-fold change in

287 c loci that are more susceptible to cytidine deaminase, we set up a high-throughput assay for assessi

288 By deleting all threonine deaminases, we generated a strain in which isoleucine bi

289 APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicat

290 R) is induced by activation-induced cytidine deaminase, which initiates a cascade of events leading t

291 tion defect caused by reduction of adenosine deaminase, which is also observed in induced astrocytes

292 OBEC3 family of single-stranded DNA cytosine deaminases, which inhibits virus replication through dea

293 , a disfavored context for wild-type APOBEC1 deaminase, while maintaining efficient editing in all ot

294 mbers, is a single-stranded (ss)DNA cytosine deaminase with antiviral activity.

295 We also evolved a CBE based on CDA1 deaminase with much higher editing efficiency at difficu

296 crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site at 2.2 A.

297 a single-stranded DNA (ssDNA) deoxycytidine deaminase with two domains, a catalytically active, weak

298 APOBEC3G is a cytidine deaminase with two homologous domains and restricts retr

299 osine base editor (A&C-BEmax) by fusing both deaminases with a Cas9 nickase to achieve C-to-T and A-t

300 an cells express up to 9 active DNA cytosine deaminases with functions in adaptive and innate immunit