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1 y for safely and noninvasively treating this debilitating disease.
2 ver spontaneously, but some develop chronic, debilitating disease.
3 e bedsides of patients with this chronic and debilitating disease.
4 thritis has reinvigorated research into this debilitating disease.
5 novel therapeutic targets for, this chronic, debilitating disease.
6  or treat the vascular complications of this debilitating disease.
7 apeutic strategies for the treatment of this debilitating disease.
8 risk because of old age (> 70 yr) or serious debilitating disease.
9 n of specific prevention strategies for this debilitating disease.
10 ncover novel therapeutic strategies for this debilitating disease.
11 approaches to the management of this common, debilitating disease.
12 or the discovery of novel therapies for this debilitating disease.
13 ating new and existing therapeutics for this debilitating disease.
14 es of progression to higher severity of this debilitating disease.
15 possible personalized medicine for this very debilitating disease.
16 ation of myosin motors, as mutations lead to debilitating disease.
17  autoimmune axis in the pathogenesis of this debilitating disease.
18 n human diseased tissue that facilitate this debilitating disease.
19  and a potential therapeutic target for this debilitating disease.
20  of Na(V)1.7 and lead to severe pain in this debilitating disease.
21  and effective therapeutic strategy for this debilitating disease.
22 ential new therapeutic avenues to treat this debilitating disease.
23 ess challenges in unresponsive cases of this debilitating disease.
24  advances in understanding and treating this debilitating disease.
25 nd treatment of patients suffering from this debilitating disease.
26 , and millions have suffered from the highly debilitating disease.
27 eatment, and follow-up in patients with this debilitating disease.
28 ) provides a potential gene therapy for this debilitating disease.
29 n, which causes periodic outbreaks of highly debilitating disease.
30 e tested now to slow the progression of this debilitating disease.
31 apies currently under investigation for this debilitating disease.
32 s suggest novel therapeutic targets for this debilitating disease.
33  at increasing frataxin levels to treat this debilitating disease.
34 ggests alternative treatments for this often-debilitating disease.
35 strategies that are aimed at preventing this debilitating disease.
36 n resistance that are characteristic of this debilitating disease.
37 low Quarter Horse breeders to eliminate this debilitating disease.
38 d there are currently no treatments for this debilitating disease.
39 those afflicted by this rare and potentially debilitating disease.
40  based on soluble pathogenic markers for the debilitating disease.
41 ng, measuring, and ultimately treating these debilitating diseases.
42 nt continued occurrence of these potentially debilitating diseases.
43 patients with cognitive decline due to other debilitating diseases.
44 , and dysregulation of UPR underlies several debilitating diseases.
45 ochondrial Ca(2+) handling can contribute to debilitating diseases.
46 act on treatment of SHP-2 dysfunction linked debilitating diseases.
47  approach for treating otherwise terminal or debilitating diseases.
48  are being developed to ameliorate otherwise debilitating diseases.
49              ADAM17 is implicated in several debilitating diseases.
50 ens which cause periodic outbreaks of highly debilitating diseases.
51 alliative treatments exist for this group of debilitating diseases.
52 peutic strategies for the treatment of these debilitating diseases.
53 ide is a contributing factor of many chronic debilitating diseases.
54 atic, some progress to develop the fatal and debilitating disease adult T-cell leukemia/lymphoma (ATL
55            Feline hyperthyroidism (FHT) is a debilitating disease affecting > 10% of elderly cats.
56                           Endometriosis is a debilitating disease affecting 190 million women worldwi
57               Osteoarthritis (OA) is a major debilitating disease affecting approximately 27 million
58 ain.SIGNIFICANCE STATEMENT Chronic pain is a debilitating disease affecting approximately one in thre
59                    Chronic pancreatitis is a debilitating disease affecting millions worldwide.
60         Osteoarthritis (OA) is a painful and debilitating disease affecting over 500 million people w
61                            Hypertension is a debilitating disease affecting the population worldwide.
62        Rheumatoid arthritis is a chronic and debilitating disease, affecting an estimated 1% of the p
63                    Psychiatric disorders are debilitating diseases, affecting >80 million people worl
64 ntravascular, parasitic flatworms that cause debilitating disease afflicting >200 million people.
65 hematopoietic response to schistosomiasis, a debilitating disease afflicting more than 200 million pe
66 asitic helminths that cause a chronic, often debilitating disease afflicting over 200 million people
67 ns of the central nervous system can lead to debilitating disease and death.
68 Understanding the mechanisms that cause this debilitating disease and identifying biomarkers for diag
69            Peripheral nerve injury can cause debilitating disease and immune cell-mediated destructio
70 (WHO) set ambitious goals of control of this debilitating disease and its elimination as a public hea
71 ally manifest in early childhood and lead to debilitating disease and premature death.
72 ogical levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, an
73   We discuss selected mycoviruses that cause debilitating diseases and/or reduce the virulence of the
74 ebrate hosts, in which EEEV induces a highly debilitating disease, and the outcomes are frequently le
75   Dysregulation of human NSTs causes several debilitating diseases, and NSTs are virulence factors fo
76 formed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene
77 yloid aggregates are associated with several debilitating diseases, and there are numerous efforts to
78                  Surprisingly, many of these debilitating diseases are caused by repeat expansions in
79 athic pulmonary fibrosis (IPF) is a severely debilitating disease associated with a dismal prognosis.
80 th nasal polyps (CRSwNP) can be a severe and debilitating disease associated with significant morbidi
81 eutic strategies for the treatment of severe debilitating diseases associated with type I IFNs due to
82        Agents that show promise for averting debilitating disease-associated complications have also
83  derived from clone p19/wenv17 caused severe debilitating disease at 5 to 7 days postinfection; initi
84 tions, efforts to reduce the burden of these debilitating diseases can be improved.
85 atients with GNE myopathy, a progressive and debilitating disease caused by a genetic defect in siali
86 ic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigar
87                              PL is a chronic debilitating disease caused by increased accumulation of
88 loidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthy
89                         Oropouche fever is a debilitating disease caused by Oropouche virus (OROV), a
90                           Leishmaniasis is a debilitating disease caused by protozoan parasites of th
91 ular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, s
92                         Cystic fibrosis is a debilitating disease characterized by a poor medical pro
93 erited restrictive cardiomyopathy (RCM) is a debilitating disease characterized by a stiff heart with
94                    Secondary lymphedema is a debilitating disease characterized by abnormal soft tiss
95 egypti and Ae. albopictus mosquitoes, causes debilitating disease characterized by an acute febrile p
96 stomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflamma
97                          Osteoarthritis is a debilitating disease characterized by cartilage degradat
98 e systemic sclerosis (SSc; scleroderma) is a debilitating disease characterized by excessive dermal f
99                Neuropathic pain is a chronic debilitating disease characterized by mechanical allodyn
100             Pulmonary hypertension (PH) is a debilitating disease characterized by remodeling of the
101                           Endometriosis is a debilitating disease characterized by the growth of ecto
102                                 The severely debilitating disease Congenital Muscular Dystrophy Type
103                           Tendinopathies are debilitating diseases currently increasing in prevalence
104 wel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory
105 s into amyloid fibrils is a hallmark of many debilitating diseases, from Alzheimer's and Parkinson di
106 fected; knowledge critical for understanding debilitating disease hallmarks, including cardiovascular
107 s dry eye syndrome, a widely encountered and debilitating disease in ageing populations.
108 responsible for recent epidemic outbreaks of debilitating disease in humans.
109  Protein aggregation is associated with many debilitating diseases including Alzheimer's, Parkinson's
110                                 A variety of debilitating diseases including diabetes, Alzheimer's, H
111 y and resolution, hindering the diagnosis of debilitating diseases including phenylketonuria, tyrosin
112              Human aging is characterized by debilitating diseases, including heart failure, cardiac
113                                         Many debilitating diseases, including neurodegenerative disea
114  human use, the possibility of CHIKV-induced debilitating disease is high in many parts of the world.
115                              Buruli ulcer, a debilitating disease, is caused by Mycobacterium ulceran
116 ic spontaneous urticaria (CSU), a common and debilitating disease, is widely held not to be life limi
117 lostridioides difficile infection (CDI) is a debilitating disease leading to poor health-related qual
118 cted to molecular alterations giving rise to debilitating diseases like rheumatoid arthritis and oste
119     Septic arthritis is a severe and rapidly debilitating disease mainly caused by Staphylococcus aur
120                  MF patients have a range of debilitating disease manifestations (eg, massive splenom
121 ng sickness in humans and contributes to the debilitating disease 'Nagana' in cattle.
122 Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting fr
123                 Hv190SV is associated with a debilitating disease of its phytopathogenic fungal host.
124        Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system (CNS)
125                            Pancreatitis is a debilitating disease of the exocrine pancreas that, unde
126                    Psoriasis is a common and debilitating disease of the skin, nails, and joints, wit
127 lopment of new treatment strategies for this debilitating disease of the visual system.
128  unexplained nausea and vomiting (CUNV) is a debilitating disease of unknown cause.
129          Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimat
130                                              Debilitating diseases of the skeletal system occur when
131 rebellar ataxias are a group of progressive, debilitating diseases often associated with abnormal Pur
132 al Need for Life Threatening or Irreversibly Debilitating Diseases or Conditions document was issued
133 ments that includes humans with a variety of debilitating diseases or immune deficiencies.
134 polypeptide accumulation) are among the most debilitating diseases our aging societies face.
135 s one of the most medically and economically debilitating diseases present in the world today.
136  ultimately seek ways of preventing an often debilitating disease process.
137 ve multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligode
138               Rheumatoid arthritis (RA) is a debilitating disease, resulting in the destruction of bo
139            The hepatointestinal form of this debilitating disease results from a chronic infection wi
140 r bacteria that cause brucellosis, a chronic debilitating disease significantly impacting global heal
141  enhance DNA expansion events that result in debilitating disease states.
142 ng pathogens and pollution, that can lead to debilitating diseases such as asthma and chronic obstruc
143 lasticity could result in the development of debilitating diseases such as cancer, fibrosis, atherosc
144 to provide cell replacement therapy to treat debilitating diseases such as diabetes, Parkinson's and
145 he gastrointestinal (GI) tract that includes debilitating diseases, such as ulcerative colitis (UC) a
146 tus is the causative agent of brucellosis, a debilitating disease that affects humans and animals.
147 is responsible for Chagas disease, a serious debilitating disease that affects millions of people in
148  a high-risk locus for multiple sclerosis, a debilitating disease that also presents with excess iron
149 candidates.IMPORTANCE Chikungunya fever is a debilitating disease that causes severe pain to the join
150                                 Obesity is a debilitating disease that has become a global epidemic.
151              Interstitial cystitis (IC) is a debilitating disease that has been adversely affecting t
152 rculosis (TB) is a slow growing, potentially debilitating disease that has plagued humanity for centu
153 e pulmonary disease (COPD) is a progressive, debilitating disease that in its final stages cripples t
154              Drug addiction is a chronic and debilitating disease that is considered a global health
155 chronic lymphatic insufficiency-is a chronic debilitating disease that is frequently misdiagnosed, tr
156                               Emphysema is a debilitating disease that remodels the lung leading to r
157                        Diabetes is a chronic debilitating disease that results from insufficient prod
158                  Atopic dermatitis (AD) is a debilitating disease that significantly alters the quali
159            Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the qual
160 n the subject of intense research due to the debilitating diseases that result from its dysfunction.
161             Since their dysfunction leads to debilitating diseases, they represent key targets for ph
162 (5-FU) is the first line of therapy for this debilitating disease, treatment effectiveness is often h
163 the gut flora of children affected with this debilitating disease using shotgun metagenomic sequencin
164    Posttraumatic stress disorder (PTSD) is a debilitating disease, which affects 8-10% of the populat
165 scular necrosis of femoral head (AVNFH) is a debilitating disease, which affects the middle aged popu
166  tissues leads to a multisystemic and highly debilitating disease whose main features are dark urine,
167                       The prevalence of this debilitating disease will increase as life expectancy in
168         Major depressive disorder (MDD) is a debilitating disease with a high worldwide prevalence.
169                                Epilepsy is a debilitating disease with a strong genetic component.
170 -Gilford progeria syndrome (HGPS) is a rare, debilitating disease with early mortality and rapid onse
171                                Dystonia is a debilitating disease with few treatment options.
172 hronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional a
173                         Epilepsy is an often-debilitating disease with many etiologies.
174                              Lymphedema is a debilitating disease with no effective cure and affects
175                                Glanders is a debilitating disease with no vaccine available.
176 c fatigue syndrome (ME/CFS) is a chronic and debilitating disease with unknown cause.
177 s/chronic fatigue syndrome (ME) is a severe, debilitating disease, with substantial evidence pointing
178 oping more effective therapies against these debilitating diseases, with the potential for broader ap
179 ) is the most common inherited neuropathy, a debilitating disease without known cure.
180 in light chain-derived (AL) amyloidosis is a debilitating disease without known cure.

 
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