ライフサイエンスコーパス: decarboxylate

1 and 3-indolepyruvate, respectively) and then decarboxylated.

2 nd subsite to the first subsite, where it is decarboxylated.

3 ydroxybenzoate, which is then prenylated and decarboxylated.

4 xide via an intermediate that is oxidatively decarboxylated.

5 ted that the clavulanic acid intermediate is decarboxylated.

6 ce, the ability of the D37A mutant enzyme to decarboxylate 2'-deoxyOMP was measured.

7 The enzyme did not decarboxylate 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hy

8 t the parental NTera-2 teratocarcinoma line, decarboxylate [2-(15)N]glutamine to form gamma-[15N]amin

9 nd competes with a minor pathway that merely decarboxylates 2OG to succinate as it oxidatively fragme

10 urface plasmon resonance effect of gold, can decarboxylate a wide range of aromatic and aliphatic car

11 reby T. pseudonana produces and subsequently decarboxylates a C4 acid via PEPC2 and PYC, respectively

12 RG1 protein and identified its cis-aconitate decarboxylating activity in an enzymatic assay.

13 We show that the NAD(+)-dependent decarboxylating activity is contained in the 360 amino a

14 sely proportional to intracellular levels of decarboxylated AdoMet (dcAdoMet).

15 ng to reduction of a Schiff base adduct with decarboxylated AdoMet.

16 vity, whole cells of the mutant were able to decarboxylate alpha-[U-(14)C]ketoglutarate and [U-(14)C]

17 widespread in microbes, acting in concert to decarboxylate alpha-beta unsaturated carboxylic acids us

18 nent of mammalian multienzyme complexes that decarboxylate alpha-ketoacids and catabolize glycine.

19 A DisA-dependent decarboxylated amino acid may inhibit the formation of a

20 lar to amino acid decarboxylases, a panel of decarboxylated amino acids was tested for effects simila

21 anthraquinone carboxylic acid (DMAC) and its decarboxylated analog, aloesaponarin.

22 hydroindolizine-8-carboxylate as well as its decarboxylated analogue, 6-(2-bromophenylamino)-2,3-dihy

23 opylamine (3MTP) and isoamylamine (IAA), the decarboxylated analogues of methionine and leucine, usin

24 also employed this high-energy ionization to decarboxylate and analyze PFCAs by MS/MS (for the first

25 However, because pro-OCN is not efficiently decarboxylated and activated during bone resorption, ina

26 previously shown that several thyronamines, decarboxylated and deiodinated metabolites of the thyroi

27 Blue102 is cleaved out from the chromophore, decarboxylated and remains attached to the preceding Phe

28 phosphorylation, this precursor is oxidized, decarboxylated and then reductively thiolated to form Co

29 rial type III polyketide synthase (PKS) that decarboxylates and condenses four malonyl-CoA molecules

30 influenced by a tumor's capacity to take up, decarboxylate, and store amine precursors.

31 xanoyl-CoA and glutaramyl-CoA, which are not decarboxylated, are modestly affected by the mutations.

32 orporating d isomers at the P8 position or a decarboxylated arginine mimetic, we obtained analogues w

33 Like L-arginine, agmatine (decarboxylated arginine) also activated NO synthesis, ho

34 ne ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine.

35 enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and a

36 The distribution of agmatine (decarboxylated arginine) was mapped in the central nervo

37 lished that agmatine, an endogenously formed decarboxylated arginine, is a weak competitive inhibitor

38 nce response of Escherichia coli operates by decarboxylating arginine.

39 ndicate that oxygen limitation restricts the decarboxylating arm of the tricarboxylic acid cycle, whi

40 n to its principal functions, BAL can slowly decarboxylate aromatic amino acids such as benzoylformic

41 n, although uncharged 1-methylorotic acid is decarboxylated at a similar rate.

42 four of the substrate acetate groups can be decarboxylated at the same catalytic center.

43 , and report that, in vitro, AAO oxidatively decarboxylates auxin, suggesting a mechanism for regulat

44 generation of red fluorescent proteins and 6-decarboxylated betaxanthin pigments.

45 e tumor models via LAT1 transport but is not decarboxylated by AADC.

46 In a competing reaction, ACMS is decarboxylated by ACMS decarboxylase (ACMSD) for further

47 This compound is decarboxylated by ClaH to yield emodin, which is then co

48 The 10-carboxyl group was readily decarboxylated by heating in DMSO at temperatures of 110

49 so obtained were saponified and then readily decarboxylated by heating in Me2SO solution to provide t

50 Thialysine is, in turn, decarboxylated by lysine decarboxylase, releasing CO2 th

51 acid side-chains attached to C12 and C18 are decarboxylated by sirohaem decarboxylase, a heterodimeri

52 chain of Tyr(147) stabilizes the enolate of decarboxylated C(4) keto species ((2)H(1) half-chair) th

53 hesis was that the distillation process will decarboxylate cannabinoids hence improving cannabinoid c

54 Cannabigerols (CBGA and its decarboxylated CBG molecule) have pharmacological profil

55 make Fe-coproporphyrin (coproheme), and then decarboxylate coproheme to generate protoheme.

56 hyl-1,4-dihydro-2,4,6-trimethyl-3,5-pyridine decarboxylate (DDC) for 10 weeks followed by 1 month of

57 The enzymes of the beta-decarboxylating dehydrogenase superfamily catalyze the o

58 ) is a member of a family of metal-dependent decarboxylating dehydrogenases.

59 building block of the pigment instead of the decarboxylated derivative (DHI)?

60 peptide bond is thereby left intact, and the decarboxylated dipeptide moiety is open to subsequent re

61 recarboxylates with ease; in contrast, OXA-1 decarboxylates easily but recarboxylates with difficulty

62 that PQQ forms stable hydrated carbonyls and decarboxylates easily.

63 ne moiety as a pyridoxal phosphate-dependent decarboxylating enzyme that uses branched-chain amino ac

64 Biotechnology employs such carboxylating and decarboxylating enzymes for the carboxylation of aromati

65 ure methods have been used for assaying many decarboxylating enzymes including hydroxylation-coupled

66 distribution is atypical for glucuronic acid decarboxylating enzymes, most of which favor production

67 zyme ethylmalonyl-CoA decarboxylase (ECHDC1) decarboxylates ethyl- or methyl-malonyl-CoA, two side pr

68 Decarboxylated factor X in which the Gla residues were c

69 r factor Xa and approximately 1.5 microM for decarboxylated factor Xa.

70 Each variant was screened for its ability to decarboxylate five different substrates, i.e., benzoylfo

71 The decarboxylated form of L-arginine, agmatine, antagonizes

72 extracellular region with its intracellular decarboxylated form, agmatine (Agm(2+)).

73 man spectra obtained from nonilluminated and decarboxylated forms of wild-type GFP has provided furth

74 The stable isotope ratios of the decarboxylated fragment of PFOA span ~28 per mille with

75 n process, which ionizes the chromophore and decarboxylates Glu-222, mimics the electrostatic and str

76 However, this mutant dehydrogenase decarboxylates glutaconyl-CoA to crotonyl-CoA without ox

77 central metabolism via beta-oxidation, a non-decarboxylating glutaryl-CoA dehydrogenase and a subsequ

78 gene, GLDPA, encodes the P-subunit of GDC, a decarboxylating Gly dehydrogenase.

79 GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit int

80 ith a >CF-COOH group were stoichiometrically decarboxylated in aprotic solvents and formed products w

81 It remains to be determined where PS is decarboxylated in mitochondria and whether decarboxylati

82 inones are ring-opened by lithium iodide and decarboxylated in the presence of a mild proton source.

83 road scope of unprotected amino acids can be decarboxylated in this system, with selectivity between

84 t increases, the ability of the NHC-CO(2) to decarboxylate increases.

85 resulting from incorrect protonation of the decarboxylated intermediate at the C4' position.

86 initial substrates and the various partially decarboxylated intermediates to be bound with equivalent

87 Isocitrate dehydrogenases, IDH1 and IDH2, decarboxylate isocitrate to alpha-ketoglutarate (alpha-K

88 thesize (3)H-PtdSer and, after a 20-min lag, decarboxylate it to form [(3)H]PtdEtn.

89 to form the mitochondrial BCKDH complex that decarboxylates ketoacid derivatives of leucine, isoleuci

90 se ancestral forms have a nascent ability to decarboxylate kinetically less preferred amino acid subs

91 logs that lack AdoMetDC activity and instead decarboxylate L-ornithine or L-arginine.

92 CobD was shown to decarboxylate L-threonine O-3-phosphate to yield (R)-1-a

93 was previously demonstrated to be capable of decarboxylating l-ornithine.

94 gut-associated bacteria in their ability to decarboxylate levodopa to dopamine via tyrosine decarbox

95 decarboxylase (TgPSD1), which preferentially decarboxylates liposomal PtdSer with an apparent K(m) of

96 EAEC strain 101-1 was unable to decarboxylate lysine in vitro due to deletions in cadA a

97 t was suspected of producing the cadaverine (decarboxylated lysine) backbone.

98 irst enzyme of the polyamine pathway, Spe1p, decarboxylates lysine and forms an alternative polyamine

99 This enzyme decarboxylates lysine, an essential amino acid for denta

100 CAM plants decarboxylate Mal in the light, generating high CO(2) co

101 bon fixation, an NADP-malic enzyme (NADP-ME) decarboxylates malate in the chloroplasts of bundle shea

102 The E. histolytica malic enzyme, which decarboxylates malate to pyruvate, closely resembles tha

103 f NADP-malic enzyme (ME), the primary enzyme decarboxylating malate in bundle sheath cells to supply

104 enzymes required are described; oxaloacetate decarboxylating malic dehydrogenase is also suitable for

105 ert fumarate to malate and uses oxaloacetate decarboxylating malic dehydrogenase to convert malate to

106 P. putida FabB decarboxylates malonyl-ACP and condenses the acetyl-ACP

107 oA decarboxylase (AdCMV-MCD), an enzyme that decarboxylates malonyl-CoA to acetyl-CoA.

108 g that catalyzes cleavage of the oxidatively decarboxylated MftA peptide to liberate its final two re

109 ecursor pathway is initiated by a remarkable decarboxylating monooxygenase with high specificity for

110 vered in the slr0721 gene, which encodes the decarboxylating NADP(+)-dependent malic enzyme in the cy

111 boxysome coat protein homologue, and me, the decarboxylating NADP(+)-dependent malic enzyme.

112 n support of photosynthesis) is either fully decarboxylated or inserted as (13)C-labeled glycyl resid

113 fatty acid oxidation, cannot be explained by decarboxylated osteocalcin changes, suggesting existence

114 atic assays led to the discovery that PA4872 decarboxylates oxaloacetate (kcat = 7500 s(-1) and Km =

115 We evaluated two 4-vinylphenols, decarboxylated p-coumaric (pCA) and ferulic acid (FA), a

116 culations suggest the involvement of several decarboxylating pathways in the Kok effect, including th

117 -oxo-4(pyridin-3-yl)-3-butenoic acid and its decarboxylated product ( E)-3-(pyridine-3-yl)acrylaldehy

118 none methide of cannabigerolic acid 1 to the decarboxylated product (-)-trans-Delta(9)-tetrahydrocann

119 llular proton ending up in a C-H bond of the decarboxylated product agmatine (Agm(2+)).

120 , which ends up as a "virtual" proton in the decarboxylated product gamma-aminobutyric acid (GABA) an

121 hich it appears to encode a permease for the decarboxylated product of GadB.

122 difference between 2-thioisoorotate and its decarboxylated product, 2-thiouracil.

123 e resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carbox

124 Second, Psd1 decarboxylates PS in the outer membrane in trans, indepe

125 of 1, and salinosporamide C (4), which is a decarboxylated pyrrole analogue.

126 nt PDC1 enzyme showed that it could not only decarboxylate pyruvate, but that it also had significant

127 ccus gordonii, use pyruvate dehydrogenase to decarboxylate pyruvate.

128 ur thiamin diphosphate enzymes, all of which decarboxylate pyruvate: the E1 component of human pyruva

129 uvate:ferredoxin oxidoreductase (PFO), which decarboxylates pyruvate and forms acetyl-coenzyme A with

130 family of bacterial pyruvate oxidases which decarboxylates pyruvate to acetyl phosphate plus H2O2 an

131 alonyl-thioesters spontaneously hydrolyze or decarboxylate reactants on the crystallographic time fra

132 tosines, presumably via the ODC/ polyamines/ decarboxylated S-adenosylmethionine (dc-AdoMet) pathways

133 dition of an aminopropyl group acquired from decarboxylated S-adenosylmethionine (dcAdoMet).

134 tions in tumours affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamin

135 The characterized pathway uses decarboxylated S-adenosylmethionine as the aminopropyl g

136 onine from methylthioadenosine, a product of decarboxylated S-adenosylmethionine from the polyamine s

137 ruvoyl cofactor to catalyze the formation of decarboxylated S-adenosylmethionine, which then donates

138 Here we show that plants can decarboxylate serine directly.

139 arginine decarboxylase (speA) and ornithine decarboxylate (speC), prevented the synthesis of putresc

140 The 1.3S-CO2- intermediate decarboxylates spontaneously over a period of hours, and

141 demonstrate weak promiscuous activity on the decarboxylated substrate 1-(phenylamino)-1-deoxyribulose

142 This side reaction arises when the decarboxylated substrate intermediate is protonated at C

143 -CoAs as well as a modest preference for the decarboxylated substrate mimics acetyl-CoA and propionyl

144 traps the Schiff base between the enzyme and decarboxylated substrate, while little Schiff base speci

145 at an even lower rate, can produce IGP from decarboxylated substrate.

146 Namely, halogenases and hydroxylases alike decarboxylate the alphaKG co-substrate, facilitating for

147 oys a mononuclear transition metal center to decarboxylate the substrate in an oxidant-independent fa

148 uPFCAs by imposing high-energy ionization to decarboxylate the uPFCAs then focused on the fluorinated

149 The ketosynthase (KS) domain of EpoC decarboxylates the methylmalonyl-S-EpoC acyl enzyme to g

150 After all, the capability of NBS in decarboxylating the amino acids was further exploited in

151 ng uroporphyrinogen to coproporphyrinogen by decarboxylating the four acetate side chains of the subs

152 anidinium carboxylate 9 was shown to readily decarboxylate to form crambescidin 359 (8).

153 l acyl carrier protein (ACP) may prematurely decarboxylate to generate the corresponding acyl-ACP, wh

154 nhydrides produce intermediates that readily decarboxylate to provide delta-lactams with high diaster

155 The resulting products were then decarboxylated to afford the highly valuable C-2-CF2H-su

156 In this response, l-arginine is decarboxylated to agmatine, thereby consuming one proton

157 ydroxybutyrate (DMSHB), which is oxidatively decarboxylated to DMSP.

158 ut carboxylic acid derivatives are primarily decarboxylated to form alkyl radicals that lack the corr

159 he mitochondria by unknown gene products and decarboxylated to form phosphatidylethanolamine at the i

160 rboxylase 2 (Psd2p) in the Golgi/vacuole and decarboxylated to form phosphatidylethanolamine.

161 The closed form of 5 was further decarboxylated to generate 6, which was not photochromic

162 fatty acid biosynthesis) were hydrolyzed and decarboxylated to give C11, C13, and C15 methylketones,

163 new variation of the MVA pathway where PM is decarboxylated to give isopentenyl phosphate (IP), which

164 -PtdSer imported to the parasite interior is decarboxylated to NBD-PtdEtn, while the latter is not me

165 3,4-dihydroxyphenylserine (L-DOPS), which is decarboxylated to NE by the enzyme L-aromatic amino acid

166 independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane.

167 ting of sugars to pyruvate, which in turn is decarboxylated to produce acetyl-coenzyme A (CoA) for va

168 The resulting 18-methyl-Z12-nonadecenoate is decarboxylated to the hydrocarbon, 2-methyl-Z7-octadecen

169 P oxidizes 1 to a cation radical, which then decarboxylates to an alpha-amino radical having carbanio

170 releases carboxybiuret, which spontaneously decarboxylates to biuret.

171 This intermediate subsequently decarboxylates to CO(2) and inorganic phosphate, and the

172 We observe that imported KG decarboxylates to succinate in the cytosol and contribut

173 he Mn-enzyme gives an oxalate radical, which decarboxylates to yield a formate radical anion.

174 t enzymes found in the human microbiome that decarboxylate tryptophan to form the beta-arylamine neur

175 richia coli, the products of each gene could decarboxylate tryptophan, but were inactive against tyro

176 final two residues, including the C-terminal decarboxylated Tyr (VY*).

177 by MJ0050, the same enzyme that was found to decarboxylate tyrosine for methanofuran biosynthesis.

178 Because cell extracts from B. japonicum decarboxylated [U-(14)C]glutamate very slowly, the gamma

179 One activity is to decarboxylate UDP-glucuronic acid to UDP-beta-l-threo-pe

180 an be trapped as methyl esters or allowed to decarboxylate under mild conditions.

181 ontrast to DCB., aliphatic RCOO. radicals a) decarboxylate with a very low energetic barrier and on t

182 r either l-ornithine or l-lysine, which were decarboxylated with similar efficiency.

183 We conclude that OXA-24 not only decarboxylates with difficulty but also recarboxylates w