ライフサイエンスコーパス: decidua

1 tered based on placental location (villi vs. decidua).

2 f chorioamnionitis, neutrophils dominate the decidua.

3 ial epithelial cells, and in first-trimester decidua.

4 s and its predominant expression in maternal decidua.

5 low extravillous trophoblast invasion of the decidua.

6 ne, which is abundantly expressed in uterine decidua.

7 ce of IFN-gamma within early human pregnancy decidua.

8 peripheral blood and in the pregnant uterine decidua.

9 nd IL-1beta enhance MCP-1 in first trimester decidua.

10 al role in anchoring the embryo/fetus to the decidua.

11 mulate cytotrophoblast migration through the decidua.

12 stitial and is restricted to the mesometrial decidua.

13 t the chorioallantoic placenta and enter the decidua.

14 ts, the fetal cells that invade the maternal decidua.

15 alpha-OHase expression in human placenta and decidua.

16 ls of expression occurred in first trimester decidua.

17 of a highly specialized maternal tissue, the decidua.

18 monstrate the production of prolactin by the decidua.

19 gh the use of an alternative promoter in rat decidua.

20 dization; this induction is localized to the decidua.

21 ctivated during colonization of the maternal decidua.

22 d to controls and macrophage subtypes in the decidua.

23 etained in Tenrec and resembling early human decidua.

24 ed by senescence in the neighboring maternal decidua.

25 fetal-derived trophoblasts and the maternal decidua.

26 from the chorion and invade deeply into the decidua.

27 arrier to initial colonization of the murine decidua.

28 r regulatory events might occur in the human decidua.

29 nism promoting trophoblast invasion into the decidua.

30 decrease in uNK cells in cKO versus control decidua.

31 iltration of fetal-specific T cells into the decidua.

32 gulated in cKO decidua compared with control decidua.

33 ere with normal stepwise EVT invasion of the decidua.

34 th a physiological, angiogenic role in human decidua.

35 tation window and in first-trimester uterine decidua.

36 vasive extravillous trophoblasts that invade decidua.

37 was upregulated in preeclamptic placenta and decidua.

38 lack of iTreg cell overrepresentation in the decidua.

39 g and are likely to be the major APCs in the decidua.

40 ing factor expression levels in preeclamptic decidua.

41 ntly increased DAG and total PKC activity in decidua (1.5- and 1.4-fold, respectively) and embryos (1

42 apoptosis and proliferation in the maternal decidua, a decrease in proliferation and increase in apo

43 Embryo implantation induces formation of the decidua, a stromal cell-derived structure that encases t

44 nd spiral artery development in the maternal decidua, accompanied by significantly attenuated niT cel

45 ey are also abundant in the pregnant uterine decidua, although their role there is unknown.

46 c1)) is shown to be a product of the uterine decidua and a regulator of postimplantation intrauterine

47 L-6 (p < 0.001) and IL-8 (p < 0.001) in both decidua and amnion compared with healthy (control) condi

48 L-6) and prostaglandins, in the chorioamnion-decidua and amniotic fluid (AF).

49 e along an invasive pathway, penetrating the decidua and anchoring the placenta to the uterus.

50 in developing embryos but is present in the decidua and chorion early in development.

51 T cells obtained from human third trimester decidua and demonstrated that decidual CD4(+) and CD8(+)

52 s and extravillous trophoblast subtypes, the decidua and even in placental debris in the maternal vas

53 Among these traits are the maternal decidua and fetal component of the placenta, but there i

54 ein was noted at the border between maternal decidua and fetal trophoblasts.

55 in excessive trophoblast migration into the decidua and increased TUNEL-positive signal.

56 ravillous trophoblast cell (EVT) invasion of decidua and inner third of the myometrium is critical fo

57 placental anchoring villi into the maternal decidua and its vessels, is thought to be an underlying

58 compositional and structural changes in the decidua and myometrium but had no effect on their micro-

59 rative contributions of two sites of action (decidua and ovary) toward preterm birth.

60 Viruses can gain access to the decidua and placenta by ascending from the lower reprodu

61 emical inhibition of RIG-I activation in the decidua and placenta did not protect against fetal demis

62 Viral tropism for the decidua and placenta is then dependent on viral entry re

63 VT) cells were isolated from early pregnancy decidua and placenta.

64 regnancy, fetal trophoblast cells invade the decidua and remodel maternal spiral arteries to establis

65 n placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal bl

66 oles in placental invasion into the maternal decidua and spiral artery remodeling.

67 a laminar array at the boundary between the decidua and the nondecidualized endometrium.

68 The major MFI compartments, the decidua and the placenta, each responded in distinct man

69 indicates that efficient GAS invasion of the decidua and the restricted host immune response favored

70 st with fetal cytotrophoblasts occupying the decidua and uterine blood vessels.

71 wer in DC nuclei in abruption versus control decidua and was absent from ITs; GR was higher in IT tha

72 Trophoblast cells penetrate through the decidua and well into the metrial gland, where they form

73 express TF potentiating inflammation in the deciduas and leading to miscarriages.

74 e and respond to IFN-lambda in the placenta, decidua, and endometrium.

75 nant leukocyte population in first-trimester decidua, and genetic studies point to a role of alloreco

76 In vivo studies confirmed recombination in decidua, and GRIC-ERKdko placentas showed reduced ERK2 e

77 er infection of the adjacent immunocompetent decidua, and heterozygous Mavs+/- or Ifnar1+/- dams carr

78 , how their function is regulated within the decidua, and how they variously contribute to pregnancy

79 infection in lungs, salivary glands, uterine decidua, and injured chorionic villi of the placenta, de

80 into the surrounding tissues, i.e., embryo, decidua, and maternal circulation.

81 plicates in invasive cytotrophoblasts in the decidua, and maternal immunoglobulin G (IgG)-CMV virion

82 detectable in individual immune cells of the decidua, and these levels are further enhanced specifica

83 (PCP) component, fail to invade in maternal decidua, and this deficiency results in middle-gestation

84 ferentiated stroma toward the outside of the decidua, and TIMP-3 mRNA was expressed in primary and so

85 EVTs, isolated from donor-matched placenta, decidua, and trophoblast organoids (TB-ORGs), revealed b

86 was necessary to infect both human and mouse deciduas, and the data support the existence of a barrie

87 In human decidua, angiotensinogen is expressed only in spiral art

88 Colonization of the maternal decidua appears to be an initial step in the maternal co

89 here are distinct types of epithelium in the decidua approaching parturition at single cell resolutio

90 t the predominant immune interactions in the decidua are between the placental trophoblast and matern

91 NK cells that populate the decidua are important regulators of normal placentation.

92 mplement and recruitment of neutrophils into decidua are required for fetal loss, and emphasize the i

93 phoblast invasion and vascular conversion in decidua are thought to be the primary defect of common p

94 a, are elevated, prompting evaluation of the decidua as a potential source of this excess, circulatin

95 olony-stimulating factor expression in human decidua as well as in a mouse model of preeclampsia.

96 nts identify candidate targets unique to the decidua as well as those shared across diverse cell type

97 gnant endometrial cells of uterus nor in the decidua at 12.5 day p.c.

98 localized CYP2J2 in trophoblastic villi and deciduas at 12 weeks and term.

99 In this study, dNK from human term pregnancy decidua basalis and decidua parietalis tissues were comp

100 but instead is found in stromal cells of the decidua basalis and metrial gland and following infectio

101 metrial glands at g.d. 8, 10, and 12 and in decidua basalis at g.d. 12 (p < 0.05).

102 Analysis of the decidua basalis from early pregnancy demonstrated expres

103 Freshly isolated decidua basalis macrophages expressed lower levels of IL

104 Decidua basalis samples (8 to 12 weeks gestation) were e

105 Decidua basalis sections from term (n = 10), idiopathic

106 ls to the site of listerial infection in the decidua basalis, and infection by Listeria remained unre

107 ls with luminal narrowing and a hypocellular decidua basalis.

108 at has a predilection for replication in the decidua basalis.

109 murine samples were spatially restricted to decidua basalis.

110 With the regression of the decidua beginning on day 9.5, a coordinated upregulation

111 ith the nonpregnant endometrium and pregnant decidua being the least stiff, most viscous, least diffu

112 interface, fetal cytotrophoblasts invade the decidua, breach maternal blood vessels, and form heterot

113 a, betaII, delta, and zeta were increased in decidua by 1.25- to 2.8-fold.

114 ial, mesenchymal, and chorion) and maternal (decidua) cells cultured in four compartments interconnec

115 S induced a proinflammatory phenotype in the decidua characterized by a decrease in HLA-DR and an inc

116 ated cytotoxicity were down-regulated in cKO decidua compared with control decidua.

117 ro assays showed that second-trimester human decidua conditioned medium stimulated transendothelial P

118 Absence of BMPR2 signaling in the uterine decidua consequently suppressed IL-15, VEGF, angiopoieti

119 opment and uterine decidualization, and that decidua contributes to their control by a coordinated ex

120 ross talk between the placenta (hCG) and the decidua (CXCL10) in the control of immune cell recruitme

121 epithelium and lymphatic endothelium in the decidua, cytotrophoblasts, and smooth muscle cells in bl

122 Tissue NK cells in the decidua (dNK) express inhibitory NK receptors (iNKR) tha

123 the major lymphocyte population of the human decidua (dNKs), express genes with immunomodulatory pote

124 In humans, FST is up-regulated in the decidua during early pregnancy, and women with recurrent

125 dometrium during the luteal phase and in the decidua during early pregnancy.

126 ocytes in the human uterine mucosa, known as decidua during pregnancy, or endometrium otherwise, was

127 in placental cells that invade the maternal decidua during pregnancy.

128 lasts, the fetal cells invading the maternal decidua during pregnancy.

129 cus on the events that occur in the maternal decidua during the first few weeks of human pregnancy, b

130 ravillous trophoblast invasion into maternal decidua during the first trimester, optimizing hemochori

131 Host-pathogen interactions in the decidua during this early stage of infection remain poor

132 rial stroma-derived secretory tissue, termed decidua, during early pregnancy.

133 (DS) cells and maternal immune cells in the decidua (endometrium of pregnancy).

134 Because abruptions elicit intense decidua-enhanced thrombin production, we examined the re

135 Compared to CONV-R dams, the GF maternal decidua exhibits similar vascular histomorphometric feat

136 results reveal that cells of early pregnancy decidua express strong FasL immunoreactivity, and decidu

137 opulation located in the rat antimesometrial decidua expresses prolactin mRNA, as well as synthesizes

138 500,000 cells and 588 arteries within intact decidua from 66 individuals between 6 and 20 weeks of ge

139 ensured uterine quiescence by preventing the decidua from expressing parturition-inducing hormone rec

140 nfiltration that peaked after PPROM, whereas decidua from gestational age-matched controls were virtu

141 we used laser microdissection to isolate the decidua from tissue sections of the maternal-fetal inter

142 es-using global gene expression profiling in decidua from women who developed sPE in a previous pregn

143 The highly heterogenous maternal decidua has been increasingly recognized as a vital fact

144 ls) are either enriched or excluded from the decidua, how their function is regulated within the deci

145 ry cytokine genes Il1b, Il6, and Il10 in the decidua; Il6, Il12b, and Il10 in the myometrium; and Il1

146 hage functions are required for the maternal decidua immune responses against L. monocytogenes infect

147 ich recruitment of excess macrophages to the decidua impairs endovascular trophoblast invasion, the p

148 itute 50-90% of lymphocytes in human uterine decidua in early pregnancy.

149 and endovascular invasion into the maternal decidua in the mouse.

150 an decidual organ cultures and in the murine decidua in vivo A high inoculum was necessary to infect

151 ti-PDGF-A neutralizing antibodies into mouse deciduas in utero at Embryonic Days (E) 8.5, 9.5, and 10

152 LPS treatment to the maternal decidua induced expression of pro-inflammatory IL-6 (p <

153 hypothesis that inflammation at the chorion-decidua interface (CDI) induces labor by negating the ca

154 chemokines, such as CCL2, from the maternal decidua into the embryonic circulation.

155 In the decidua, invasive cytotrophoblasts expressing coreceptor

156 Virus replicates in the decidua, invasive cytotrophoblasts that breach the uteri

157 Decidua is a transient uterine tissue shared by mammals

158 First trimester human decidua is composed of decidual cells, CD56(bright)CD16(

159 The decidua is infiltrated by many immune cells promoting pr

160 results suggest that the infectivity of the decidua is not the result of an enhanced recruitment of

161 During pregnancy the uterine decidua is populated by large numbers of natural killer

162 ophoblast cells into the uterine mucosa, the decidua, is critical for successful pregnancy.

163 available only for three larch species - L. decidua, L. potaninii var. chinensis (complete genome 12

164 mpsia is shallow trophoblast invasion of the decidua leading to incomplete vascular transformation an

165 low extravillous trophoblast invasion of the decidua, leading to uteroplacental blood flow that is in

166 This inflammatory transformation of decidua leads to production of IL-8 and G-CSF, chemotact

167 trachomatis (Ct) can infect the placenta and decidua, little is known about its effects on trophoblas

168 Immunostaining of first trimester decidua localized IP-10, I-TAC, IFN-gammaR1, and -R2 to

169 The decidua maintains a tissue-specific distribution of T ce

170 rformed microarray screening of placenta and decidua (maternal placenta) from 25 preeclamptic women a

171 ng human pregnancy the chorion (fetal) lines decidua (maternal) creating the feto-maternal interface.

172 between the trophoblast (embryonic) and the decidua (maternal).

173 othesis that expression of CTLA-2beta in the decidua may regulate implantation of the embryo by neutr

174 etrial contractility, cervical ripening, and decidua/membrane activation, have been extensively chara

175 and Larix decidua Mill.

176 in the closely related European larch (Larix decidua Mill.).

177 esults suggest that DC entrapment within the decidua minimizes immunogenic T cell exposure to fetal/p

178 ived placental trophoblasts and the maternal decidua must provide antimicrobial defenses at this crit

179 PE-CVS and endometrial disorders, as well as decidua obtained postpartum from women with sPE.

180 Few DEGs were shared by PE-CVS, and PE decidua obtained postpartum.

181 in microsporocytes of European larch (Larix decidua) occurs in a pulsatile manner during prophase of

182 rine model of preeclampsia revealed that the decidua of affected animals displayed higher levels of i

183 t time demonstrable in cells of mesometrium, decidua of embryos, placenta, uterus, ovary, and brain o

184 ine stromal cells and vasculature within the decidua of gestation day 8.5 implantation sites.

185 in macrophages (CD68-positive cells) in the decidua of preeclamptic patients.

186 ryo implantation and transformation into the decidua of pregnancy.

187 production and PKC activities in embryos and decidua of streptozotocin (STZ)-diabetic or transiently

188 e natural killer (uNK) cells in the maternal decidua of the Hectd1 mutant placenta.

189 nd 2 in biopsy samples from the placenta and decidua of women with healthy pregnancies.

190 HY-specific T cells were detectable in the decidua of women with male pregnancies and were shown to

191 re enriched at the maternal-fetal interface (decidua) of women with spontaneous preterm labor.

192 hanges may occur upon NK cell entry into the decidua or other tissues expressing substantial TGFbeta.

193 study developed a six-chamber vagina-cervix-decidua-organ-on-a-chip (VCD-OOC) that recapitulates the

194 e, we developed matched trophoblast (TO) and decidua organoids (DO) from human placentas to define th

195 Chorionic EVTs adjacent to the decidua parietalis exhibited significantly higher HPGD l

196 rom human term pregnancy decidua basalis and decidua parietalis tissues were compared with pNK and fi

197 ostly pioneer species: Betula pendula, Larix decidua, Picea abies, and Pinus sylvestris; and alien sp

198 theses in Abies alba, Fagus sylvatica, Larix decidua, Picea abies, Pinus sylvestris, Quercus petraea,

199 -fetal interface that comprises the maternal decidua, placenta, and fetal membranes.

200 the uterine glands impact development of the decidua, placenta, and fetus.

201 ester and full-term placentas separated into decidua, placental villi and chorionic plates.

202 e maternal leukocytes of the first-trimester decidua play a fundamental role in implantation and earl

203 Using human first trimester placenta, decidua, primary dNK cells, and macrophages, we tested t

204 A ends, we cloned a full-length cDNA for rat decidua prolactin, whose sequence was identical to that

205 d a higher sO2 than the junctional zone plus decidua region (JZ+D) in C57Bl/6 mice.

206 participate in the formation and function of decidua remain poorly understood.

207 n, the role of the uterine epithelium in the decidua remains poorly understood.

208 Immunohistochemical staining of human decidua revealed the expression of CD1d on both villous

209 Here we provide evidence that decidua-secreted HtrA1 and HtrA3 antagonize HtrA4-mediat

210 The decidua secretes various factors that act in an autocrin

211 is associated with lymphangiogenesis in the decidua since lymphatic vessels were not a prominent fea

212 It is well established that the human decidua synthesizes and releases prolactin.

213 mpared with most bacteria, was higher in the decidua than in the adjacent placenta.

214 d cell proteins were found more often in the decidua than in the placenta, suggesting that the uterus

215 olled by the specialized uterine stroma (the decidua) that surrounds the implanted conceptus.

216 iderable T cell infiltration of the maternal decidua, the functional properties of this T cell respon

217 Within the decidua, the maternal immune system undergoes continued

218 We also discuss the role of the maternal decidua, the periconceptional maternal-embryonic interfa

219 n in an ex vivo infection model of the human decidua, the puerperal fever portal of entry.

220 ffector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating th

221 ls derived from three lineages: the maternal decidua, the trophectoderm, and the extra-embryonic meso

222 raembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to

223 lpha-OHase was detectable in trophoblast and decidua; the latter being stronger in decidualized strom

224 We found dynamic HAND2 expression in the decidua throughout the menstrual cycle and pregnancy, gr

225 st that ZIKV spreads from basal and parietal decidua to chorionic villi and amniochorionic membranes

226 xpansion associated with an inability of the decidua to mount appropriate innate cellular immune resp

227 xplain how EVTs coordinate with the maternal decidua to promote a tissue microenvironment conducive t

228 e relevance of uterine DCs (uDCs) within the decidua to the success of implantation has remained uncl

229 day 8.5, the antimesometrial and mesometrial decidua transcriptome was noticeably altered in LIF-repl

230 derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-co

231 o an anti-inflammatory placental bed, termed decidua, under homeostatic control of uterine natural ki

232 zed angiotensinogen transcription in uterine decidua using in situ reverse transcription PCR.

233 metrial epithelial cells and first trimester decidua via a Gq-Ca(2+)-cSrc-mitogen-activated protein k

234 n extravillous trophoblast (EVT) invades the decidua via integrin receptors and subsequently degrades

235 Neutrophil infiltration in the chorio-decidua was a common feature to both LPS and E. coli.

236 1alpha-OHase expression in decidua was approximately 1000-fold higher in first (95%

237 t female mice at proestrus and GnRHR mRNA in decidua was enriched compared to whole implantation site

238 amount of dystroglycan mRNA in 8.5 day p.c. decidua was indeed 100-fold higher than that of non-preg

239 However, a reduction of RNLS in the decidua was observed with all cases of PEC, while the le

240 in the placenta, and uterine myometrium and decidua, was also attenuated.

241 for nutrient exchange and (ii) the maternal decidua, where mononuclear, extravillous trophoblasts an

242 uces considerable adult BMDCs recruitment to decidua, where some differentiate into nonhematopoietic

243 his expansion is even more pronounced in the decidua, where there is an overrepresentation of iTreg c

244 er in DC nuclei during labor versus prelabor decidua, whereas FKBP51 immunostaining was undetected in

245 of uILC3s is found in human endometrium and decidua, which are mostly NCR(+) and partially overlap w

246 mpaired development or function of the human decidua, which unlike that of the mouse contains lymphat

247 n defects such as a much smaller mesometrial decidua with enlarged SDZ.

248 was higher in DCs in abruption than control decidua, with total ERK 1/2 unchanged.

249 um reached the cervical epithelial cells and decidua within 48 h and did not cause cell death in VCD-

250 emokine compartmentalisation on the maternal decidua, without which chemokines enter the embryonic ci