ライフサイエンスコーパス: decidualization

1 ng that it is a key mediator of BMP2-induced decidualization.

2 BMP2 regulation in stromal cells undergoing decidualization.

3 isolated from pregnant mouse uterus undergo decidualization.

4 P action in the mouse uterine stroma during decidualization.

5 he uterine stroma undergoes a process called decidualization.

6 transcriptional programs which lead to full decidualization.

7 ing trafficking of NK precursor cells during decidualization.

8 ld-type and Hoxa-10(-/-) mice after inducing decidualization.

9 ic structures, and for the execution of full decidualization.

10 se inhibitor, is expressed during PR-induced decidualization.

11 d angiogenesis required for implantation and decidualization.

12 Cox-2 expression and only modestly affected decidualization.

13 p38 inhibition also significantly inhibited decidualization.

14 nduced Cox-2 and PPARdelta expression during decidualization.

15 ry PG that is essential for implantation and decidualization.

16 is essential for blastocyst implantation and decidualization.

17 ovulation, fertilization, implantation, and decidualization.

18 les of uterine glands in embryo survival and decidualization.

19 g its resistance to invasion acquired during decidualization.

20 d WT genotypes in the presence or absence of decidualization.

21 ecognized genetic and chemical modulators of decidualization.

22 is critical for endometrial receptivity and decidualization.

23 pithelial-stromal transition associated with decidualization.

24 ce with pregnancy including implantation and decidualization.

25 g endometrial receptivity, implantation, and decidualization.

26 in blastocyst implantation and stromal cell decidualization.

27 ockdown of GPR64 in hESCs remarkably reduced decidualization.

28 its potential physiological significance on decidualization.

29 in blastocyst implantation and stromal cell decidualization.

30 etrial stromal cells (hESCs) during in vitro decidualization.

31 ffects 238 genes (154 up and 84 down) during decidualization.

32 ty of bioactive androgens and the process of decidualization.

33 mal cell proliferation and completely failed decidualization.

34 gression, which together promotes successful decidualization.

35 ultiple signaling modalities required during decidualization.

36 regulator of cytoskeletal remodeling during decidualization.

37 evelopment, but also embryo implantation and decidualization.

38 ed in mouse uterine stromal cells undergoing decidualization.

39 decidual cells in a unique process known as decidualization.

40 Uterine decidualization, a key event for successful implantation

41 Endometrial decidualization, a prerequisite for successful pregnanci

42 Uterine decidualization, a process that occurs in response to em

43 -2) in the uterine epithelium contributes to decidualization, a series of uterine morphological chang

44 ipid mediator lysophosphatidic acid (LPA) in decidualization, acting through its G-protein-coupled re

45 ngolipid metabolism regulates proper uterine decidualization and blood vessel stability.

46 .g., 4h-j) were active orally in the uterine decidualization and component C3 assays in the rats.

47 ain IL-33(+) cell types in the uterus during decidualization and early placentation, whereas ST2 is e

48 e human endometrium, with purported roles in decidualization and implantation.

49 , resulting in the disruption of stroma cell decidualization and loss of embryo viability after impla

50 t neutralization of CB1 signaling suppresses decidualization and misregulates angiogenic factors.

51 The most affected hub genes were related to decidualization and NK cell function.

52 st function during the progressive phases of decidualization and placentation.

53 Overall, we suggest that proper regional decidualization and polyploidy development requires FoxM

54 K119ub1, in conjunction with perturbation of decidualization and polyploidy development, suggesting a

55 l stroma, thereby playing important roles in decidualization and pregnancy.

56 fferentiation, all fundamental processes for decidualization and pregnancy.

57 xpression of stromal PR was decreased during decidualization and preimplantation period in Stat3(d/d)

58 Proteinase activity is controlled by stromal decidualization and specific proteinase inhibitors.

59 ometrial stromal-specific defects precluding decidualization and successful pregnancy.

60 secrete extracellular vesicles (EVs) during decidualization and that this process is controlled by a

61 es multiple signaling mechanisms crucial for decidualization and these studies provide additional per

62 efects in implantation chamber formation and decidualization, and abnormal vascular remodeling during

63 al PPARdelta is critical to implantation and decidualization, and embryonic PPARdelta is vital for pl

64 sub-fertile due to defects in implantation, decidualization, and endometrial receptivity from disrup

65 g increased localized vascular permeability, decidualization, and expression of Bmp2 at the sites of

66 PS-blastoids underwent implantation, induced decidualization, and generated live, albeit disorganized

67 ted lower embryo resorption rates, preserved decidualization, and improved spiral artery remodeling c

68 ach phase of the mouse estrous cycle, during decidualization, and into aging.

69 ox transcription factor, is regulated during decidualization, and its conditional deletion in mice re

70 mpaired endometrial responsiveness, aberrant decidualization, and loss of pregnancy.

71 olecular link that coordinates implantation, decidualization, and placentation crucial to pregnancy s

72 naling pathways participate in implantation, decidualization, and placentation, whether there is a co

73 ity to blastocyst implantation, stromal cell decidualization, and placentation. Uterine gland dysfunc

74 plays multiple roles in embryo implantation, decidualization, and postpartum repair.

75 le allows for proper steroid responsiveness, decidualization, and pregnancy.

76 ry for normal embryo development and uterine decidualization, and that decidua contributes to their c

77 o defects in embryo attachment, stromal cell decidualization, and the inability to cease estrogen-ind

78 receptivity, uterine cell proliferation and decidualization are compromised resulting in complete ab

79 tiation and endothelial proliferation during decidualization are not fully understood.

80 allow mechanistic analysis of site-specific decidualization are strikingly limited.

81 n endometrial stromal cells, which inhibited decidualization, as reflected by the impaired induction

82 velopment of patient-specific treatments for decidualization-based recurrent pregnancy loss, subferti

83 ignature of impaired endometrial maturation (decidualization) before and during early pregnancy.

84 gulation of Fra-1 expression during in vitro decidualization blocked stromal differentiation and resu

85 Analysis of cell cycle progression during decidualization both in vivo and in vitro demonstrates t

86 ent uterine implantation and induced uterine decidualization but did not develop substantially therea

87 ants undergo implantation and induce uterine decidualization but rapidly degenerate around the time o

88 A/RARA signaling prevents initiation of HESC decidualization, but not maintenance of the decidualized

89 responses in pre-decidual cells accelerated decidualization by eliminating the emergence of senescen

90 42-3p plays an important role in endometrial decidualization by regulating the expression of major de

91 in in response to E2 treatment or artificial decidualization compared with controls; however, express

92 1 and HtrA3 expression is up-regulated under decidualization conditions in endometrial stromal and ep

93 Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy

94 of top3alpha-/- embryos and the induction of decidualization could occur, but viability of these embr

95 ere, we discover the footprint encoding this decidualization defect comprising 120 genes-using global

96 Decidualization defects can cause poor placentation, int

97 eveals failure of implantation with regional decidualization defects such as a much smaller mesometri

98 ted deletion of Hoxa-10 in mice shows severe decidualization defects, primarily due to reduced stroma

99 Decidualization denotes the process of inflammatory repr

100 Our studies show two major aspects of decidualization downstream of Hoxa-10.

101 ual nest volume is a measurable indicator of decidualization efficacy and correlates with the probabi

102 Finally, the main modulators of decidualization, estrogen receptor 1 (ESR1) and progeste

103 We show that decidualization (even in vitro) enhances the ability to

104 Of interest, P4 supplementation rescued decidualization failure and supported pregnancy to full

105 e Parp1, Parp2 knockout mice, but subsequent decidualization failure results in pregnancy loss.

106 din (PG) biosynthesis, show implantation and decidualization failure.

107 the epithelia, accompanied with a widespread decidualization feature in the stromal fibroblasts.

108 ed with the dynamic network of the defective decidualization fingerprint.

109 unique phenomenon that occurs during uterine decidualization following embryo implantation, although

110 receptor, Tie-2, directs angiogenesis during decidualization following implantation.

111 that impact embryo survival and stromal cell decidualization for pregnancy success.

112 n function of PARP-1 and PARP-2 in mediating decidualization for successful pregnancy establishment.

113 Decidualization has not yet been systematically studied

114 he receptors and ligands up-regulated during decidualization have their counterpart expressed in trop

115 C3/AKR1C3), b) establishment of endometrial decidualization (IGFBP1, prolactin) and c) endometrial r

116 d throughout gestation, presenting errors in decidualization, immune cell invasion, and early spiral

117 y, as their ablation results in a failure of decidualization, impaired implantation, and embryonic re

118 y, as their ablation results in a failure of decidualization, impaired implantation, and embryonic re

119 us, the transcriptomic signature of impaired decidualization implicates dysregulated hormonal signali

120 ition of Notch signaling results in impaired decidualization in both women and a transgenic mouse mod

121 entation rescued implantation and subsequent decidualization in CD1, but not C57BL6/129, null females

122 pite normal ovarian functions and artificial decidualization in conditional knockout (cKO) mice, abse

123 regulation of regional uterine stromal cell decidualization in implantation, at the mesometrial tria

124 IL-11 is essential for embryo attachment and decidualization in mice.

125 or shared molecular pathways of dysregulated decidualization in preeclampsia and endometrial disorder

126 ls proliferate, avert apoptosis, and undergo decidualization in preparation for implantation; however

127 n addition, mutant uteri exhibited decreased decidualization in response to artificial stimuli.

128 entify the fingerprinting encoding defective decidualization in sPE and its subsequent validation.

129 Surprisingly, experimentally induced decidualization in the absence of blastocysts failed in

130 lphaSMA is associated with the initiation of decidualization in the baboon endometrium.

131 MP2 and Wnt4 that mediates P-induced stromal decidualization in the mouse and the human.

132 rotein beta (C/EBPbeta) critically regulates decidualization in the mouse.

133 d failure of embryo implantation and stromal decidualization in the uterus contribute to significant

134 P2 in human endometrial stromal cells during decidualization in vitro in response to steroids and cAM

135 tiation, but not maintenance of primary HESC decidualization in vitro.

136 exaggerated inflammatory response to induced decidualization, including altered immune cell recruitme

137 ation and subsequent defects in stromal cell decidualization, including decreased proliferation, aber

138 All but one miRNA were downregulated upon decidualization, including miR-542-3p.

139 he regulation of stromal cell polyploidy and decidualization induced by HB-EGF depend on cyclin D3 in

140 We also demonstrate the impact of decidualization-induced changes on ECS components, and t

141 ng) is a fine balance between proliferation, decidualization, inflammation, hypoxia, apoptosis, haemo

142 r of transcription-3 (Stat3) is required for decidualization, interacting with progesterone receptor

143 Because endometrial stromal cell decidualization is also critical to human reproductive h

144 Uterine stromal cell decidualization is an essential part of the reproductive

145 These data suggested that failed decidualization is an important contributor to down-regu

146 Maternal contribution to sPE through failed decidualization is an important determinant of placental

147 In fact, decidualization is associated with global hyposumoylatio

148 Deficiency in endometrial stromal cell decidualization is considered a major contributing facto

149 The process of decidualization is critical for pregnancy maintenance in

150 ands impact embryo survival and stromal cell decidualization is incomplete.

151 One hallmark event of decidualization is the acquisition of stromal cell polyp

152 f ovarian progesterone as a key regulator of decidualization is well established, the requirement of

153 asts (ESC) into specialised secretory cells (decidualization) is fundamental to the establishment of

154 ovulation, fertilization, implantation, and decidualization, it is not clear which PGs are involved

155 e strategies for successful implantation and decidualization may lead to approaches to improve the ou

156 biosynthesis of endometrial androgens during decidualization may play a key role in endometrial recep

157 Using a murine artificial decidualization model, pharmacological inhibition of Not

158 In vitro decidualization models suggest that Cnr1 levels substant

159 rting implantation, regulating the extent of decidualization, modulating local levels of vascular IGF

160 tudies of hits revealed that the majority of decidualization modulators are acutely sensitive to ovar

161 Ontology analysis revealed several groups of decidualization modulators, including many previously un

162 yps (n = 4), endocervical polyp (n = 1), and decidualization (n = 2).

163 anscriptional coregulators, is essential for decidualization of both human and murine endometrial str

164 suggest that Gpr64 has a crucial role in the decidualization of endometrial stromal cells.

165 Decidualization of ESC resulted in significant time-depe

166 RNAs differentially expressed in response to decidualization of HESCs.

167 mans, SLC5A1 expression was upregulated upon decidualization of primary endometrial stromal cells.

168 ogesterone (P4) signaling is crucial for the decidualization of the endometrial stromal cells for suc

169 , namely the attachment reaction followed by decidualization of the stroma.

170 Decidualization of the uterine mucosa drives the materna

171 The decidualization of uterine stromal cells is a key event

172 romal expansion, gland formation, and marked decidualization otherwise absent in Hoxa11-/- mice.

173 on of C/EBPbeta increased further during the decidualization phase of pregnancy and was localized in

174 ns of the decidual reaction-implantation and decidualization-pivot on the time-sensitive loss of prog

175 of embryonic growth due to interference with decidualization, placental and yolk sac formation, and e

176 reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic

177 ibitors of activated STAT (PIAS) family upon decidualization pointed toward a role of these E3 ligase

178 during human endometrial stromal cell (HESC) decidualization, primary HESCs and decidualized primary

179 h), patched, and noggin become restricted as decidualization proceeds.

180 this transcription factor in regulating the decidualization program.

181 ecipient HESCs, supporting and advancing the decidualization program.

182 to normalized uterine expression of numerous decidualization-related genes and rescue of pregnancy lo

183 The high-throughput decidualization reporter cell line and the findings desc

184 Endometrial decidualization represents an essential step for the suc

185 Endometrial decidualization resistance (DR) is implicated in various

186 oter as a quantifiable visual readout of the decidualization response (hESC-PRLY cells).

187 In co-culture experiments, accelerated decidualization resulted in entrapment of collapsed huma

188 lture of the HtrA4-expressing JAR cells with decidualization stimuli-treated T-HESC or Ishikawa monol

189 addition, inhibition of p38 led to decreased decidualization suggesting that an intracrine prostanoid

190 ity and angiogenesis during implantation and decidualization, suggesting that one cause of the failur

191 progesterone (P4) secretion that compromised decidualization, terminating pregnancy.

192 mice triggered midgestation abnormalities in decidualization that resulted in abnormal vascular devel

193 Decidualization, the process by which the uterine endome

194 Decidualization, the rapid proliferation and differentia

195 ovulation, fertilization, implantation, and decidualization; the latter of which can be restored in

196 dometrial stromal fibroblasts (ESFs) undergo decidualization to regulate embryo implantation.

197 hanism underlying the in vivo defect linking decidualization to sPE is unknown.

198 tioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR

199 verall, Cbx4/Ring1B-containing PRC1 controls decidualization via regulation of extracellular gene rem

200 ng at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathw

201 e pharmacological activation of LPA3 induces decidualization via up-regulation of HB-EGF and COX-2.

202 disorders are also associated with aberrant decidualization, we asked whether they share molecular f

203 Studies found that embryo survival and decidualization were compromised in glandless FOXA2-defi

204 ults to 17beta-estradiol (E2) and artificial decidualization were measured.

205 y, blastocyst implantation, and stromal cell decidualization, which are key events in pregnancy estab

206 d to be due to alterations in the process of decidualization, which was confirmed using in vitro mode

207 troma, affecting endometrial receptivity and decidualization, while not affecting E2-mediated epithel

208 re predominantly utilized in antimesometrial decidualization with polyploidy.

209 ngosine kinase (Sphk) genes causes defective decidualization with severely compromised uterine blood

210 de blastocyst-uterine attachment and stromal decidualization with vascular permeability changes.

211 -cKO mice also responds poorly to artificial decidualization, with lower levels of proliferation and

212 of uterine implantation and induced maternal decidualization yet failed to develop substantially ther