ライフサイエンスコーパス: decline in

1 nitive disorder) is defined by a significant decline in 1 or more cognitive domains that interferes w

2 erved [56.2% (42.3 - 66.8)] with the largest decline in 4 - 5 year-old children [24.5% (-34.2 - 57.5)

3 prior (177)Lu-PSMA treatment showed any PSA decline in 8 patients and a decline of at least 50% in 5

4 We show that the slow decline in (90)Sr follows a double-exponential function,

5 density dependence to drive diversity, could decline in a future warmer, drier world.

6 pect to early mortality and renal functional decline in a population with type 2 diabetes and advance

7 Aging involves decline in a range of functional abilities and phenotype

8 Within groups, CV declined in a statistically significant fashion from bas

9 We uncovered declines in aboveground carbon averaging 22% along edges

10 ies, such as the northern pintail, have been declining in abundance.

11 of the COVID-19 pandemic, there was a marked decline in acute cardiovascular hospitalizations, and pa

12 he major pathological correlate to cognitive decline in AD.

13 misleadingly suggested a 38-percentage-point decline in admissions related to the intervention becaus

14 than standard school practice at preventing declines in adolescent physical activity.

15 n the previous long-term average, leading to declines in adult returns beginning in 2008.

16 on of the neurobiological bases of cognitive decline in aging populations may provide critical insigh

17 tyle since midlife may help reduce cognitive decline in aging.

18 endometrial tissues peaked on day 3 and then declined in all mice with or without deficiency in adapt

19 Biodiversity intactness declined in all three scenarios, yet the decline was sma

20 s occurs early and correlates with cognitive decline in Alzheimer's disease (AD).

21 ue of PET biomarkers in predicting cognitive decline in Alzheimer's disease, over and above MRI measu

22 wealthiest neighborhoods even though median declines in ambient PM(2.5) were similar.

23 eimer's disease and a predictor of cognitive decline in aMCI.

24 ic degeneration predates the onset of memory decline in an AD-centred initiative, with a crucial invo

25 Declines in animal body sizes are widely reported and li

26 s, PAM protein levels dropped, followed by a decline in ANP precursor (proANP) levels.

27 show while all types exhibited considerable declines in area, losses of lagoonal mangroves (- 6.9%)

28 Late-life declines in avian song, and possibly other sexual traits

29 de in men and accompanied by a male-specific decline in B-cell specific loci.

30 cortex, which is known to correlate with the decline in behavioral memory precision observed with inc

31 sening of glycemia associated with continued decline in beta-cell function.

32 nthropogenic activities have led to a global decline in biodiversity, and monitoring studies indicate

33 Despite recent findings of unprecedented declines in biodiversity and ecosystem services and thei

34 tion, specifically ozone, is associated with declines in bird abundance in the United States.

35 An impaired decline in blood pressure at rest is typical in people w

36 over a 32-year period (1986-2018) and an 11% decline in body condition of fruit-dependent forest elep

37 Declines in body condition (1980-2017), which positively

38 There was a linear decline in both parameters for the more common song type

39 red with men (2.19 versus 3.11 per 1000) but declined in both groups.

40 polymer REP 2139-Ca is accompanied by rapid declines in both HBsAg and HDV RNA.

41 al of HDAC1 activation to counter functional decline in brain aging and neurodegeneration.

42 Decline in brain glucose metabolism is a hallmark of lat

43 nvironmental conditions were associated with declines in breeding probability at both colonies.

44 Declines in breeding seabirds on St Kilda, UK, have been

45 ithin the IL-10(+) cluster had a significant decline in C-peptide levels in the period preceding the

46 asets of a wide range of markers highlight a decline in capillary and artery numbers, but not of peri

47 pair cardiac contractility associated with a decline in cardiac energetics and show that the mechanis

48 y damage of the myocardium and corresponding decline in cardiac function.

49 , morphine, and the combination promotes the decline in CD4(+) T cells in HIV-infected mice.

50 uity, characterised by pronounced downstream declines in channel size and local termination.

51 PCV10-type carriage declined in children <5 years and adults post-PCV10 intr

52 ms were especially high in the tropics, with declines in CI of ~20 to 40 percentage points on average

53 A decline in circulating tumor DNA BRAF(V600E) variant all

54 eased risk for graft failure (and functional decline in class 2 at 24 months postdiagnosis; serum cre

55 On average, DR extended lifespan and delayed decline in climbing ability, but there was a lack of cor

56 T. gondii may protect against age-associated decline in cognition.

57 se with decreasing symptoms were spared from decline in cognition.

58 anol intake (1987-1998) with 15-year rate of decline in cognitive performance from mid- to late life

59 CV13) implementation resulted in significant declines in community-acquired alveolar pneumonia (CAAP)

60 rt that antipsychotic efficacy in rat models declines in concert with extracellular striatal dopamine

61 th resultant increases in sexual contact and declines in condom use.

62 despite the survivorship in both treatments declining in continued exposure to OA.

63 ography angiography (CTA) revealed a gradual decline in contrast above the level of the carotid bulb.

64 ne Nf-L and GFAP were associated with faster decline in cortical thickness.

65 lizumab may be needed for those showing slow declines in CRP.

66 Larger absolute declines in CWS arsenic concentrations at higher water a

67 ort, assault and suicide, offset partly by a decline in deaths from falls in older ages.

68 d structural equation modeling, we show that declines in decomposer diversity and abundance explain r

69 The estimated decline in diarrheal prevalence with household distance

70 5% CI -7.1 to -3.0; P < 0.001) and a greater decline in diastolic BP (-2.1 mm Hg, 95% CI -3.6 to -0.6

71 ely predict which specific stressors lead to declines in different populations or contexts, hindering

72 em productivity in wet years compared to the decline in dry years, and negative AI indicates a greate

73 pment of the AD-like pathology and cognitive decline in DS, and for this reason the system could repr

74 total marine-derived omega-3 PUFAs with less decline in DSST.

75 n DWRT; higher total omega-6 PUFAs with less decline in DWRT; and higher total omega-3 and total mari

76 ipid total MUFAs was associated with greater decline in DWRT; higher total omega-6 PUFAs with less de

77 nitive scores to estimate the rate of annual decline in each participant.

78 at, with the potential loss of diversity and decline in ecosystem resilience.

79 line serostatus in reducing dengue with some decline in efficacy during the second year.

80 In the second year after vaccination, a decline in efficacy was observed [56.2% (42.3 - 66.8)] w

81 and end-stage renal disease (ESRD) or >=50% decline in eGFR (1.17, 1.05-1.30).

82 1.29), incident CKD (1.28, 1.18-1.39), >=30% decline in eGFR (1.23, 1.15-1.33), and end-stage renal d

83 me to a composite progression outcome (>=40% decline in eGFR, with eGFR<60 ml/min per 1.73 m(2), or E

84 Age at death was unrelated to residual decline in episodic memory but was related to residual d

85 e precipitation regimes, and that there is a decline in evolutionary diversity above 1,490 mm of mean

86 and compensatory polycythaemia mitigated the decline in exercise performance in acute hypoxia through

87 ension, type 2 diabetes (T2D), and cognitive decline in experimental models of IH patterned after O2

88 l strategy, when coupled with the well-known decline in fertility as women age, maximizes reproductiv

89 ment and access to contraception will hasten declines in fertility and slow population growth.

90 a caused anatomic pathology and a functional decline in fetal and adult mice.

91 sociated with lower lung function and faster decline in FEV(1) over 10 years, in a threshold manner,

92 Marine ecosystem models predict a decline in fish production with anthropogenic ocean warm

93 Inbreeding depression, measured as the decline in fitness-related traits per unit inbreeding, d

94 rtunities for sexual selection, showed rapid declines in fitness and complete extinction through the

95 evolved populations and clones show apparent declines in fitness.

96 rass biomass was the principal cause of this decline in flammability as tree density increased, but i

97 Decline in FM and WC, but not LM, over 1 year were each

98 Decline in FM was significantly associated with lower ri

99 s exhibit independent and linear age-related declines in four of these measures: hemoglobin, alkaline

100 Our analysis reveals an 81% decline in fruiting over a 32-year period (1986-2018) an

101 tom temperature) is a tipping point of rapid decline in gadid biomass and catch.

102 ganglion cell axons, we showed a significant decline in GCL thickness, as well as MRW and peripapilla

103 those with Q4 NfL values showed a -2.3 point decline in GCP score (-2.3 points, 95% CI = -4.7 to -0.9

104 e adducts were higher in patients with early decline in GFR, compared to those with stable GFR.

105 of patients with T1DM with and without early decline in GFR.

106 The decline in global efficiency was significantly associate

107 The XRT group exhibited a significant decline in global IQ, working memory, and processing spe

108 espiration quotient from 1.0 leads to a 2.3% decline in global oxygen, a large expansion of low-oxyge

109 ax) during the green-up period and a sharper decline in GPP(max) during the dry-down period, with les

110 ost immunity to tumors in association with a decline in GrB-expressing immunosuppressive cells within

111 (r(2) = 0.88-0.98; p < 0.1), resulting in a decline in greenness with increasing annual litterfall (

112 s expanding in Florida and the Caribbean but declining in Hawaii.

113 th HIV was feasible and resulted in a strong decline in HCV incidence and prevalence.

114 Substantial declines in HCV incidence and prevalence among GBM with

115 the underpinnings of progressive functional decline in HD.

116 decreased from 2011 through 2017, owing to a decline in health care-associated infections.

117 ses, acquired pathologies, and aging-related declines in health.

118 one effective solution to prevent cognitive decline in healthy aging.

119 hracycline-based chemotherapies induce early decline in heart mass in cancer patients.

120 Aging leads to a decline in hematopoietic stem and progenitor cell (HSPC)

121 baseline GFAP > 232pg/ml showed 160% faster decline in hippocampal volume compared to those with val

122 factorial process that is characterized by a decline in homeostatic capacity, best described at the m

123 This steep decline in homeostatic plasticity is accompanied by redu

124 There was significant daily decline in hospitalizations in March 2020 (-5.9% per day

125 The rate of decline in incidence of neonatal endogenous endophthalmi

126 Recent reports of dramatic declines in insect abundance suggest grave consequences

127 for type 1 diabetes experienced a more rapid decline in insulin secretion compared with children with

128 Decline in insulin sensitivity due to dysfunction of adi

129 iped water coverage was associated with 4.4% decline in intensity of re-infection (incidence rate rat

130 to fragmentation of populations and a severe decline in its distribution.

131 tomography images of stems revealed that the decline in K(shoot) occurred with the formation of an ai

132 ic disorders, characterized by a progressive decline in kidney function due in part to the formation

133 s that increase acid excretion but lead to a decline in kidney function.

134 uces oxidant stress which contributes to the decline in kidney function.

135 Our results indicate that the decline in lamin B1 underlies stem cell aging and impact

136 te infection had no impact on age-associated decline in learning and memory and that by 20 months pos

137 ne of the significant factors underlying the decline in life expectancy in the US.

138 Notably, a decline in liver triglycerides alongside increased activ

139 suggest that the consequences of the ongoing decline in local newspapers will negatively affect socia

140 erate emphysema at baseline CT showed a mean decline in lung density of 3.6 g/L +/- 1.0 (P < .001) an

141 luent emphysema at baseline CT showed a mean decline in lung density of 4.6 g/L +/- 1.1 (P < .001), 6

142 ulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, sug

143 subsequent cardiac magnetic resonance with a decline in LV ejection fraction >=10% and absolute LV ej

144 longitudinal and circumferential strains and declines in LV ejection fraction and fractional shorteni

145 ted changes in haematopoiesis that include a decline in lymphopoiesis and skewing towards the myeloid

146 mission intensity sources, leading to larger declines in major pollutant emissions, but very limited

147 though river ice extent has been shown to be declining in many regions of the world(1), the seasonali

148 is most likely a consequence of the overall decline in marine productivity following the last glacia

149 sociated with variable rate and magnitude of decline in markers of immune activation.

150 A progressive decline in maximum heart rate (mHR) is a fundamental asp

151 of IR in obese subjects is associated with a decline in MCR(I) that represents a compensatory respons

152 er snow disappearance, with somewhat smaller declines in meadow soil.

153 rs after initiation, there was a significant decline in meropenem and imipenem initiation ("first sta

154 in mortality at older ages or a slowdown in declines in midlife mortality.

155 dase activity in patients, and a progressive decline in mobility and respiratory function.

156 ented vulnerability paradigms-niche novelty (decline in modeled suitability), temporal novelty (stand

157 und that agricultural intensification led to declines in modularity but increases in nestedness and c

158 nts in diagnosis and treatment have led to a decline in mortality rates, morbidity rates have remaine

159 Surprisingly, BDNF protein declined in mPFC but was elevated in dorsal striatum (DS

160 F versus those who achieved a 30% or greater decline in MRI-PDFF (MRI-PDFF responders) relative to ba

161 s data regarding the association between 30% decline in MRI-PDFF relative to baseline and histologic

162 response in those who achieved less than 30% decline in MRI-PDFF versus those who achieved a 30% or g

163 Declines in MRI-PDFF of >=30% were experienced by 39% of

164 Most of the decline in MRSA BSIs was from decreases in USA100 BSI in

165 Historical declines in multiple insect taxa have been documented ac

166 ging behaviour was initially normal and only declined in mutants in the second year of life.

167 tion of leaky vaccine effect to the observed decline in mVE.

168 Thus, age-related decline in neuronal health or expression of disease-asso

169 he Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, bu

170 most stringent lockdown measures had faster declines in new reports of smell/taste changes following

171 "hardening hypothesis," which proposes that declines in nicotine use resulting from population-level

172 cts are associated with memory and cognitive decline in normal aging and mild cognitive impairment re

173 s, distribute uniformly during the peak, and decline in numbers during later stages of EAE.

174 miR-146a expression declined in old wild-type mice, and loss of miR-146a pro

175 Reproductive decline in older female mice can be attributed to a fail

176 strategy for combating age-related cognitive decline in otherwise healthy individuals.

177 ies with exposed anthers experiencing larger declines in ozone displayed more dramatic pigmentation i

178 We report a decline in parasitism that represents a reduction in an

179 tatistically significant predictor of memory decline in participants initially recruited in ADNI as h

180 April and 24th May 2020, corresponding to a decline in patient admissions with COVID-19 during the o

181 comes and slowed the rate of kidney function decline in patients with and without CKD, and regardless

182 he prevention of vascular-mediated cognitive decline in patients with atrial fibrillation.

183 volved in the loss of synapses and cognitive decline, in patients with AD.

184 own in England has resulted in a significant decline in PCI procedures.

185 Nonetheless, there is early evidence of a decline in per capita primary care visit rates, and litt

186 7%) of top-performing hospitals showed large decline in percentile rankings compared with baseline.

187 episodic memory but was related to residual decline in perceptual speed.

188 This decline in performance is in part due to incompleteness

189 ed was associated with a modest differential decline in performance on the patient-experience measure

190 parabiosis we report that thymic involution, declines in peripheral T-cell counts, and reduced major

191 were seen, but patients with CD had greater decline in phosphate than those with UC.

192 modifiable factors that may prevent further decline in physical function with aging.

193 O(2)] failing to alleviate the aphid-induced decline in plant C allocated to the AM fungus.

194 Declines in platelet concentration correlated significan

195 Widespread concern over declines in pollinating insects has led to numerous reco

196 Declines in pollinator populations are thought to be due

197 ly true for markers that capture the risk of decline in pre-symptomatic stages of AD, as this would a

198 amyloid and tau is detrimental to cognitive decline in preclinical Alzheimer's disease during late m

199 ds contents, meanwhile NMR analysis showed a decline in primary metabolites content as sugars fructos

200 eins, and demonstrate an early age-dependent decline in proliferation and neurogenesis.

201 The normal age-related decline in proportions of submucosal dopaminergic neuron

202 A greater than or equal to 30% decline in PSA at 6 wk was associated with longer overal

203 ficiency was significantly associated with a decline in psychomotor speed in the group with severe WM

204 - and short-DUP patients experienced similar declines in psychosocial function, but declines occurred

205 A decline in pulmonary function occurs 4 days after peak v

206 nd cardiovascular hospitalizations and slows decline in quality of life compared with placebo.

207 It leads to age-related declines in reproduction (reproductive senescence) and s

208 ulnerability resulting from aging-associated decline in reserve and function across multiple physiolo

209 n and women to DTG would lead to a sustained decline in resistance levels, whereas using DTG-based AR

210 However, endemics with small ranges did decline in response to logging.

211 and postprandial MitoPS rates significantly declined in response to 20 g milk protein ingestion (CTL

212 ants; population of phytophagous Orthoptera declined in response to phytophagous Coleoptera and tota

213 ized an intraocular pressure (IOP)-dependent decline in retinal pyruvate levels coupled to dysregulat

214 eeking explanations for the equator-to-poles decline in richness of most groups of organisms, namely

215 There was a significant decline in risk-adjusted mortality (11.8% in 2005 to 9.7

216 ation during glucose deprivation-induced ATP decline in Saccharomyces cerevisiae.

217 Declines in salmon size, primarily resulting from shifti

218 the Mekong River delta has suffered a large decline in sediment supply causing coastal erosion, foll

219 We found evidence of a decline in seroprevalence in both countries over a two-y

220 n the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant

221 This decrease was related to a decline in SNF days per beneficiary (from 26.2 to 21.3 d

222 The decline in SOC cancelled out the increment in C stocks i

223 .44, 95% confidence interval: 0.24, 0.78); a decline in social capital after the disaster elevated th

224 This is evident in the sharp decline in social mobility in the Midwest as economic ac

225 in proportion to nitrogen addition-dependent declines in soil pH and losses of plant diversity.

226 ere has been important work on mechanisms of decline in some species, it generally remains unclear wh

227 The observed decline in species diversity under simultaneous N and CO

228 Our study also highlights possible temporal declines in species richness over 30 years and thus the

229 e global evidence on the drivers of national declines in stunting prevalence and compares the relativ

230 e suggest that walnuts might delay cognitive decline in subgroups at higher risk.

231 Future projections suggest substantial declines in suitable habitat, but not necessarily loss o

232 and extinction risk, with an overall sigmoid decline in survival through time.

233 early life increases, followed by senescent declines, in survival and reproduction.

234 ys an important role in explaining cognitive decline in SVD, which was however not independent of ima

235 lear tau tangles and modestly slow cognitive decline in symptomatic Alzheimer's disease (AD).

236 ondary outcome analyses, there was a greater decline in systolic BP in the intervention than UC group

237 ne is not associated with greater spirometry decline in SZ-AATD, suggesting that cessation attenuates

238 ducts are potential biomarkers for early GFR decline in T1DM and MA.

239 ess whether-and how-humanity can reverse the declines in terrestrial biodiversity caused by habitat c

240 peak pDC frequency, we detected a transient decline in the ability of pDCs to produce IFNalpha in vi

241 ajor determinant of age-related regenerative decline in the adult hippocampus.

242 , in contrast, towards winter, a large-scale decline in the air temperature, significantly shallower

243 is in both water conditions was mainly due a decline in the chlorophyll content (non-stomatal limitat

244 e comparison did not account for the similar decline in the control group.

245 The laparoscopic era brought about a decline in the conventional surgical management of commo

246 ctions, which plays a primary role in memory decline in the early stage of AD.

247 The study defined CKD progression by a >=50% decline in the eGFR, initiation of maintenance dialysis,

248 ining cognitive function and delay cognitive decline in the elderly, but physical fitness (PF) could

249 own or knockout, which was associated with a decline in the expression of c-Myc-activated target gene

250 resents a model for age-related regenerative decline in the fly intestine and discusses recent findin

251 ensity at the membrane neck, where the steep decline in the Gaussian curvature likely triggers ESCRT-

252 om this facility was associated with a rapid decline in the incidence of L. monocytogenes ST6 infecti

253 The rate of decline in the infantile population was 7% from 2007 thr

254 ate less than 15 V that leads to significant decline in the infrared transmission by a magnitude of o

255 lication defects, in part by causing a rapid decline in the level of TUBGCP6.

256 This hypomyelination was accompanied by a decline in the number of myelinating oligodendrocytes an

257 This revealed a decline in the number of residues driving amyloid format

258 nts is lymphopenia, which largely reflects a decline in the numbers of CD4/CD8 T cells but not B cell

259 eakened recall Ab response associated with a decline in the population of memory-phenotype B cells.

260 y the presence of a long-tailed but monotone decline in the probability of interaction with distance,

261 bbreviated analysis, also showed a frequency decline in the scarcer southeast Pacific song type n.1 b

262 age-related tauopathy, we compared rates of decline in the sum of boxes score from the CDR(R) Dement

263 The permeability enhancers cause a decline in the TEER value, but only saponin alters the c

264 The primary outcome was the rate of decline in the total score on the Amyotrophic Lateral Sc

265 now levelled off, which is coincident with a decline in the use of the antiresorptive agents.

266 n children, which results in slower rates of decline in the within-age temporal trend of those congen

267 st demersal species in the north central GoM declined in the first few years following DWH, more rece

268 ident acute myocardial infarction (AMI) have declined in the United States, yet disparities by sex re

269 ent coronary heart disease (CHD) events have declined in the United States.

270 The incidence of APSGN has sharply declined in the Western world, whereas the number of Sta

271 ians were the only taxa that experienced net declines in the analysed data, while birds, mammals and

272 marine phytoplankton, resulting in universal declines in the rate of carbon fixation with short-term

273 s with both HBV and HCV should contribute to declines in the rates of viral-associated HCC.

274 Disturbance causes sharp declines in the short term and is followed by regrowth i

275 tivity increases in northern California, but declines in the south.

276 A decline in these lipids has been observed in such diseas

277 esence and onset of VI, and subsequent VRQoL declines, in these individuals.

278 Since then, the HIV prevalence has declined in this population, however, the impact of thes

279 Cyclin/Cdk1 activity normally declines in tight association with increasing N/C and is

280 The proportion of patients reporting a decline in total cognitive score was similar among the 2

281 s scores at the postworkshop assessment, the decline in total skills scores at delayed assessment (F[

282 e-related increase in type 2 cytokines and a decline in type 3 cytokines.

283 CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 media

284 estation of human activity, but biodiversity declines in undisturbed forest represent hidden losses,

285 diameter zone corresponded to 34.8 letters' decline in VA.

286 Declines in VA, initiation in IOP medication, and age we

287 4% (95% confidence interval [CI], 9% to 19%) decline in viral load for each additional year in durati

288 LY-CoV555 appeared to accelerate the natural decline in viral load over time, whereas the other doses

289 cted rhesus macaques, an earlier and sharper decline in viral load was consistently detected for the

290 ty maturation to GP is associated with rapid decline in viral replication and illness severity.

291 3 months postpartum in women with concurrent declines in viremia compared with those with stable vire

292 tent early peak and set point viremia, rapid declines in viremia to undetectable plasma titers follow

293 Furthermore, decline in WC was significantly associated with lower ri

294 In contrast, decline in WC was significantly associated with lower ri

295 s of plague had changed, leading to its slow decline in Western Europe over the subsequent 200 y, a p

296 The malaria prevalence has declined in western Kenya, resulting in the risk of neur

297 -term cardiac immunopathology and functional decline in wild type and Clec9a-depleted mice lacking DC

298 ging infectious diseases are responsible for declines in wildlife populations around the globe.

299 n wine chemical properties were apparent and declines in wine colour and tannin were particularly evi

300 and peak body ice content were predicted to decline in Wood Frogs across most of our study region, w