ライフサイエンスコーパス: decondensation

1 ci within heterochromatin and leads to their decondensation.

2 us for transcriptionally regulated chromatin decondensation.

3 ation of histones by PAD4 mediates chromatin decondensation.

4 ited by Sec13 and required for Sec13-induced decondensation.

5 these proteins was associated with chromatin decondensation.

6 n the paternal compartment as early as sperm decondensation.

7 ion, and Cdk2 inhibitors reduce the level of decondensation.

8 ith this locus induces large-scale chromatin decondensation.

9 l II pausing, and Pol II-dependent chromatin decondensation.

10 d TRRAP involved in chromatin remodeling and decondensation.

11 reasing histone citrullination and chromatin decondensation.

12 lian genome results in large-scale chromatin decondensation.

13 receded by histone acetylation and chromatin decondensation.

14 ism for chlamydial nucleoid condensation and decondensation.

15 ee energy landscape for DNA condensation and decondensation.

16 ing why this region is particularly prone to decondensation.

17 s mediated by lamin B receptor and chromatin decondensation.

18 and relieve the heat-induced heterochromatin decondensation.

19 elongation and heat shock-induced chromatin decondensation.

20 sis of nuclear proteins leading to chromatin decondensation.

21 nuclear histone citrullination, and nuclear decondensation.

22 surrounding regions, indicative of localized decondensation.

23 ells leading to p38 MAPK-dependent chromatin decondensation.

24 driven at least in part by global chromatin decondensation.

25 lacement from chromatin and global chromatin decondensation.

26 with paternal Ube3a silencing and chromatin decondensation.

27 e hypoosmotic conditions (100 mOsm/kg) cause decondensation.

28 chromatin is sufficient to induce chromatin decondensation.

29 ay, and it significantly increases chromatin decondensation.

30 al histone modification but rather chromatin decondensation.

31 oscillations of chromosome condensation and decondensation, activation and inactivation of NIMA and

32 al protein 16) possess large-scale chromatin decondensation activity but minimal transcriptional acti

33 obic peptide motif had large-scale chromatin decondensation activity comparable to the strongest full

34 The chromatin decondensation activity did not require transcriptional

35 e, we demonstrate that large-scale chromatin decondensation activity is a general property of acidic

36 Specifically, LB3T inhibits chromatin decondensation and blocks the formation of both the nucl

37 protects sperm nuclei undergoing genome-wide decondensation and chromatin assembly from becoming abno

38 fying pathogenic tau-induced heterochromatin decondensation and consequent retrotransposon activation

39 ntraction is associated with local chromatin decondensation and derepression of the DUX4 retrogene.

40 that overexpressing NCAPG2 rescued both the decondensation and egg aneuploidy phenotypes.

41 , KRP5 overexpression increases chromocenter decondensation and endoreduplication in the Arabidopsis

42 l an apparent incoordination between granule decondensation and exocytosis in the CF goblet cells.

43 Chromatin decondensation and hyperresponsiveness to TCR stimulatio

44 ord116, corresponding to increased chromatin decondensation and inhibition of Ube3a-ATS expression.

45 omesticus and Mus spretus, drives chromosome decondensation and mis-segregation in their F(1) hybrid

46 owever, HSR DNA replication is preceded by a decondensation and movement of the HSR into the nuclear

47 ack control mechanism that delays chromosome decondensation and NER in response to incomplete chromos

48 veillance mechanism that prevents chromosome decondensation and NER until effective separation of sis

49 racted this gradient and promoted chromosome decondensation and NER.

50 which lack the enzyme allowing for chromatin decondensation and NET formation, were evaluated.

51 e histones, a process required for chromatin decondensation and NET formation.

52 However, the significance of nuclear decondensation and NET generation in thrombosis is large

53 itical enzymatic role of promoting chromatin decondensation and neutrophil extracellular traps (NETs)

54 The injection inhibited chromosome decondensation and nuclear envelope formation.

55 to the prevailing 'clock' model, chromosome decondensation and nuclear envelope reformation when cel

56 , wild-type BAF completely blocked chromatin decondensation and nuclear growth.

57 entrations, wild-type BAF enhanced chromatin decondensation and nuclear growth; at higher added conce

58 otic-associated phosphorylations, chromosome decondensation and nuclear membrane reformation.

59 We conclude that Hoxb chromatin decondensation and nuclear re-organisation is regulated

60 in cytoskeletons, ER vesiculation, chromatin decondensation and nuclear rounding, progressive plasma

61 nscription that are accompanied by chromatin decondensation and nucleosome loss at HS loci.

62 ne or more events that occur after p40 locus decondensation and nucleosome remodeling and after, or i

63 phorylation of egg nucleoplasmin slows sperm decondensation and prevents basic protein removal from s

64 ures after fertilization, i.e. sperm nuclear decondensation and protamine-histone exchange.

65 that pathogenic tau-induced heterochromatin decondensation and retrotransposon activation cause elev

66 ture and transcriptional impact of chromatin decondensation and reveal an unexpected role for Myc in

67 omal DNA undergoes replication, condensation-decondensation and segregation, sequentially, in some fi

68 portant regulator of chromosome condensation/decondensation and that disruption of the MCPH1-SET inte

69 introduction of chromatin prevents chromatin decondensation and the assembly of the lamina, membranes

70 olymerization is required for both chromatin decondensation and the binding of nuclear membrane precu

71 Post-anaphase events such as chromosome decondensation and the next round of DNA replication wer

72 Due to the absence of chromosome decondensation and the suppression of genome replication

73 inhibitor staurosporine inhibited chromatin decondensation and these epigenetic modifications with t

74 These sites exhibit extensive chromatin decondensation and transcription, which abruptly turn of

75 Acetylation is correlated with chromatin decondensation and transcriptional activation, but its r

76 inates H3R26, which leads to local chromatin decondensation and transcriptional activation.

77 cells undergoes a programmed heterochromatin decondensation and transcriptional reactivation of trans

78 Cdk2 is recruited to sites of Cdc45 decondensation, and Cdk2 inhibitors reduce the level of

79 , resulting in H1 phosphorylation, chromatin decondensation, and facilitation of fork progression.

80 asters from the spindles, blocked chromosome decondensation, and inhibited telophase chromosome movem

81 r models of histone storage, sperm chromatin decondensation, and nucleosome assembly.

82 , a prevalent mark associated with chromatin decondensation, and transcription factor p53 on K120, wh

83 ght to have a role in chromatin condensation/decondensation, and we asked whether ionizing radiation

84 o loss of CenH3; centromeric heterochromatin decondensation; and bulk activation of silent rRNA genes

85 Chromatin decondensation, another characteristic of Ag-experienced

86 However, looping out and decondensation are not simply two different manifestatio

87 on remains to be determined, the kinetics of decondensation are similar to the kinetics of poly(ADP-r

88 hromatin undergoes dramatic condensation and decondensation as cells transition between the different

89 mpromised in the H2Av null mutant, chromatin decondensation at heat shock loci is unaffected in the a

90 Stepwise decondensation at high force and DNA braiding experiment

91 causes defects in the process of chromosome decondensation at late telophase.

92 structure and segregation, but not dramatic decondensation at metaphase.

93 polymerase II elongation-dependent chromatin decondensation at regions distal to DSBs.

94 e we show epigenetically regulated chromatin decondensation at snoRNA clusters in human and mouse bra

95 ir chromosomes during mid G2-phase and delay decondensation at the completion of mitosis.

96 g-deficient mutant of NuMA affects chromatin decondensation at the mitotic exit, and nuclear shape in

97 ly through stabilizing R loops and chromatin decondensation at the paternally expressed PWS Snord116

98 These data suggested that chromatin decondensation away from the surface of chromosome terri

99 ced lymphocytes and demonstrated that FRA16D decondensation/breakage occurs over a region of at least

100 major mitotic exit events such as chromosome decondensation but nonetheless allowed chromosome disjun

101 Future molecular elucidation of chromatin decondensation by Npm will significantly contribute to o

102 nitored the kinetics of DNA condensation and decondensation by protamine 1 (P1) and synthetic peptide

103 ion axis and to prevent premature chromosome decondensation by retaining Condensin I.

104 find that pathogenic tau and heterochromatin decondensation causally drive dsRNA-mediated neurodegene

105 ot simply be explained by altered global DNA decondensation, changes in histone marks or chromatin st

106 xhibits Satb2 expression-dependent chromatin decondensation consistent with Satb2 being a target gene

107 Speckle association together with chromatin decondensation correlates with expression amplification

108 ATPases RuvBL1/2 drive postmitotic chromatin decondensation, demonstrating that this is an active pro

109 neration by NADPH oxidase and also chromatin decondensation dependent upon the enzymes (PAD4), neutro

110 likely experience chromatin condensation and decondensation during a daily loading cycle.

111 endoribonuclease DICER facilitates chromatin decondensation during lesion recognition in the global-g

112 instead, the chromosomes underwent premature decondensation during mid-mitosis.

113 lination of histones that triggers chromatin decondensation during NET formation.

114 deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation.

115 BAF also mediates chromatin decondensation during nuclear assembly.

116 tical for membrane recruitment and chromatin decondensation during nuclear assembly.

117 d cells where it mediates profound chromatin decondensation during the innate immune response to infe

118 Divalent ions counteract this decondensation effect by maintaining nucleosome stems an

119 Condensation and decondensation experiments with lambda-phage DNA show th

120 A second line affects the Decondensation factor 31 (Df31) gene, which encodes a pr

121 the cell cycle, accommodating for chromosome decondensation followed by genome duplication.

122 of multilobulated nuclei, as well as nuclear decondensation followed by membrane compromise, and were

123 the egg; snky sperm did not undergo nuclear decondensation, form a functional male pronucleus, or in

124 Upon decondensation, GAGA factor and Prod shift from low affi

125 Large-scale chromatin decondensation has been observed after the targeting of

126 noic acid (RA) induced large-scale chromatin decondensation in cells expressing RARalpha; however, ce

127 ination has important functions in chromatin decondensation in granulocytes/neutrophils.

128 The decondensation in hybrid oocytes was especially prominen

129 Donut-shaped nuclei arise during chromatin decondensation in late mitosis; subsequently, cells with

130 e is known about the mechanisms of chromatin decondensation in somatic nuclei that do not contain con

131 nearly isometric expansion during chromosome decondensation in telophase and early G1.

132 ur results show that PAD4-mediated chromatin decondensation in the neutrophil is crucial for patholog

133 e DNA condensation in vitro exhibit nucleoid decondensation in vivo.

134 of 45S rDNA promoters as well as partial NOR decondensation, indicating that MAS2 negatively regulate

135 mor activity as single agents, the chromatin decondensation induced by histone deacetylase inhibitors

136 e measured the rates of DNA condensation and decondensation induced by the binding of Syrian hamster

137 then packaged within each cluster to enable decondensation into adjacent clusters.

138 through all stages of mitosis and chromatin decondensation into the G(1) stage of the next cycle.

139 , to chromatin is also effective at inducing decondensation involving phospho-H1.

140 We also demonstrate that postmitotic DNA decondensation is a gradual process, continuing for seve

141 This decondensation is mediated through chromatin-remodeling

142 ion of a noncentromeric LacO array, and this decondensation is modulated by the condensin II complex.

143 ranscriptional activation, but not chromatin decondensation, is sufficient to change replication timi

144 tic alteration of PAD4 showed that chromatin decondensation, lamin meshwork and NE rupture and extrac

145 VPA-induced chromatin decondensation led to a sequence-specific potentiation o

146 Although this is optimal for storage, decondensation limits release.

147 ompanied by nucleolus organizer region (NOR) decondensation, loss of promoter cytosine methylation, a

148 key factor in stimulating synapsis, whereas decondensation may facilitate the invasion step and/or t

149 adiation exposure and drives local chromatin decondensation near the DSB site.

150 d that echinomycin interferes with chromatin decondensation, nuclear assembly and DNA replication.

151 In contrast, chromatin decondensation, observed during the early life cycle, ac

152 chaperone and assembly factor HJURP induces decondensation of a noncentromeric LacO array, and this

153 effects were further promoted when chromatin decondensation of AML cells was induced upon S-phase ent

154 utation causing cytosine hypomethylation and decondensation of centromeres in interphase.

155 t localized adenosine triphosphate-dependent decondensation of chromatin at DSBs establishes an acces

156 erase 1 (PARP1) is responsible for the rapid decondensation of chromatin at sites of DNA damage.

157 ere Hoxd is also activated, there is visible decondensation of chromatin but no detectable movement o

158 This decondensation of chromatin correlates temporally with t

159 nown about the processes of condensation and decondensation of chromatin fibers.

160 By contrast, RSC catalyzes ATP-dependent decondensation of chromatin.

161 ulation of the AP-1 subunit, c-Jun, triggers decondensation of genomic regions containing TEs.

162 oachment of euchromatin leads to detrimental decondensation of germline chromatin and germline mortal

163 ne lysine 9 trimethylation (H3K9me3) and the decondensation of global chromatin structure.

164 x that binds histones, thereby promoting the decondensation of higher-order chromatin structures.

165 Significant decondensation of large-scale chromatin structure, compa

166 We have exploited partial decondensation of mitotic chromosomes to reveal their in

167 a two-stage disentanglement pathway: first, decondensation of mitotic chromosomes with remaining con

168 ove along the DNA template without transient decondensation of observed large-scale chromatin "chromo

169 The atmorc1 and atmorc6 mutants show decondensation of pericentromeric heterochromatin, incre

170 of ParB impeded DNA condensation or promoted decondensation of pre-assembled networks (Fisher et al.,

171 Notably, Cbx2-/- cells exhibit prominent decondensation of satellite DNA sequences at metaphase a

172 An 8-fold allele-specific decondensation of snoRNA chromatin was developmentally r

173 However, the rate and extent of decondensation of sperm chromatin in egg extracts were n

174 Decondensation of sperm chromatin in eggs is explained b

175 NAP-1, but not dNLP, was able to promote the decondensation of sperm chromatin.

176 required for anaphase I, meiosis II, or the decondensation of the meiotic products.

177 and BRM resulted in chromatin remodeling and decondensation of the MMTV repeat as demonstrated by an

178 First, PLK1 triggers a decondensation of the MTOC structure.

179 1 signalling pathway also prevents chromatin decondensation of the sperm chromatin after pronuclear f

180 Consequently, the decondensation of the sperm nucleus does not occur.

181 ving membrane depolarisation and chromosomal decondensation of the target bacteria.

182 They find that local decondensation of the template is accompanied by profoun

183 difficult to conceptualize without transient decondensation of these chromonema fibers.

184 lasmin performs the first stage of chromatin decondensation of Xenopus sperm at fertilization.

185 e assembly protein-1 (dNAP-1) to promote the decondensation of Xenopus sperm chromatin, a process tha

186 ed nuclear expansion (representing chromatin decondensation) of PMA-treated serpinb1-deficient neutro

187 Fragile sites appear as breaks, gaps, or decondensations on metaphase chromosomes when cells are

188 is altered intrinsically, inducing chromatin decondensation or cell differentiation.

189 ion potential: chromosome aneuploidy and DNA decondensation or damage are correlated with reproductiv

190 ation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophi

191 side chromosome territories, and the visible decondensation or unfolding of interphase chromatin, are

192 not inhibit lamin polymerization, chromatin decondensation, or nuclear assembly and growth.

193 d to block Cyclin B3 destruction, chromosome decondensation, or nuclear membrane re-assembly.

194 oH2A is progressively lost during pronuclear decondensation prior to synkaryogamy.

195 Although sperm DNA decondensation proceeds without NPM2, abnormalities are

196 rm cells may undergo significantly different decondensation processes following fertilization.

197 Although the detailed mechanism of this decondensation remains to be determined, the kinetics of

198 extensive expansion of NE, further chromatin decondensation, restoration of the functionality, and sp

199 hese sequences did not prevent the spread of decondensation resulting from hsp70-lacZ transcription.

200 in the nucleus, where it regulates chromatin decondensation, RNA processing, and the phosphorylation

201 he general property of large-scale chromatin decondensation shared by most acidic activators is not s

202 deacetylase inhibitor that renders chromatin decondensation, significantly decreased the number of mu

203 y after photobleaching and caused chromosome decondensation similar to the effects of H1M depletion.

204 play a role in Hc1 degradation and nucleoid decondensation since it is expressed very early in the c

205 rotamine disulfide bonds ultimately leads to decondensation, suggesting that disulfide-mediated secon

206 that ATRX loss provokes progressive telomere decondensation that culminates in the inception of persi

207 ified an epigenetic inheritance of chromatin decondensation that maintained central nuclear positioni

208 rm components, for the asynchronous male DNA decondensation that occurs following intracytoplasmic sp

209 alian cells results in large-scale chromatin decondensation that strongly correlates with histone H1

210 s that PAD4 mainly plays a role in chromatin decondensation to form NETs instead of increasing histon

211 n 40-150 mM NaCl, a distinctive condensation-decondensation transition appears between 5 and 6 pN, co

212 st a possible scenario for the gradual dsDNA decondensation upon capsid uncoating and NC loss.

213 f chromosome morphology revealed anisotropic decondensation upon digestion, with length increasing mo

214 exhibit significantly enhanced dynamics and decondensation upon epigenetic acetylation within the H3

215 ylation of RNA Pol I promoters and chromatin decondensation was apparent.

216 Neutrophil chromatin decondensation was assessed by measuring neutrophil fluo

217 Decondensation was blocked by two different drugs that i

218 The degree of decondensation was proportional to the amount of transcr

219 4 in mice), an enzyme important in chromatin decondensation, was elevated in neutrophils from individ

220 iminase 4, an enzyme that mediates chromatin decondensation, was identified to regulate both NETosis

221 apid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser mi

222 his softening was linked to global chromatin decondensation, which improves molecular diffusion withi

223 s, the donor nuclei exhibit global chromatin decondensation, which might contribute to reprogramming

224 hanol-induced condensation and water-induced decondensation, while our proposed nucleosome-like model

225 c sperm injection resulted in abnormal sperm decondensation, with the unusual retention of vesicle-as

226 ion-condensation-segregation-(cell division)-decondensation-, with SCC of unspecified length.

227 bile Mcms is reduced together with chromatin decondensation within sites of active replication, which