ライフサイエンスコーパス: dedifferentiate

1 erentiated murine myotubes can be induced to dedifferentiate.

2 Plant cells rapidly dedifferentiated.

3 d enriched among cells that were injured and dedifferentiated.

4 s, and these SMCs are hyperproliferative and dedifferentiated.

5 1 isoform A3 (ALDH(+)) as beta cells become dedifferentiated.

6 resented with well-differentiated, 143 (18%) dedifferentiated, 144 (18%) myxoid, 81 (10%) round cell,

7 quently amplified in G2 (15%), G3 (20%), and dedifferentiated (21%) chondrosarcomas.

8 constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chon

9 e 1 (18%), grade 2 (31%), grade 3 (80%), and dedifferentiated (29%) chondrosarcomas, but was not foun

10 nted with well-differentiated, 65 (37%) with dedifferentiated, 9 (5%) with myxoid, and 4 (2%) with ro

11 ancreatic injury, elimination of Numb causes dedifferentiated acinar cells to undergo apoptosis, and

12 eta-cells through cell-cell interaction with dedifferentiating acinar cells and a cell autonomous pro

13 Chondrocytes in monolayer become dedifferentiated, acquiring a fibroblast-like appearance

14 growth environments that were sufficient to dedifferentiate aged human MSCs to an early mesendoderm-

15 The proliferating Muller glia dedifferentiate and a subset of these cells differentiat

16 cancer progenitor cells have the capacity to dedifferentiate and acquire a stem-like phenotype in res

17 non-stem cancer cells have the potential to dedifferentiate and acquire stem cell properties as a di

18 uggested that alpha1T-expressing Muller glia dedifferentiate and become multipotent in response to in

19 Upon gene inactivation, these progeny can dedifferentiate and generate malignant tumors.

20 t that in older adults, meniscal cells might dedifferentiate and initiate a proliferative phenotype.

21 ongly suggest alpha1T-expressing Muller glia dedifferentiate and mediate regeneration of the injured

22 elial cell types bordering the denuded patch dedifferentiate and migrate from all sides to cover the

23 found that hypoxia induces cardiomyocytes to dedifferentiate and proliferate during heart regeneratio

24 In the damaged zebrafish retina, Muller glia dedifferentiate and proliferate to generate neuronal pro

25 n injury, surviving tubular epithelial cells dedifferentiate and proliferate, eventually replacing th

26 s) are highly plastic cells that are able to dedifferentiate and re-enter the cell cycle.

27 differentiated myelinating Schwann cell can dedifferentiate and regain the potential to proliferate.

28 a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace

29 tinal smooth muscle cells have been shown to dedifferentiate and reinitiate their myogenic program in

30 lls of the dorsal, but not the ventral, iris dedifferentiate and then differentiate to form a new len

31 state of differentiation because SCs rapidly dedifferentiated and became competent to resume prolifer

32 or progenitor cells or from cells that have dedifferentiated and become proliferative.

33 Claudin-3-/- mice revealed dedifferentiated and leaky colonic epithelium, and devel

34 p of tumors in Arf(-/-) animals presented as dedifferentiated and metastatic, with many characteristi

35 , reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell

36 Perilipin 2 was more prominent in dedifferentiated and pleomorphic liposarcomas and nearly

37 KIM1, VIMENTIN, SOX9, and KI67, indicating a dedifferentiated and proliferative state.

38 olecule up-regulated in the cells, which are dedifferentiated and undergoing replication.

39 ll to adapt to the loss of adjacent cells by dedifferentiating and proliferating.

40 opurine), GCP expand, regenerate cell walls, dedifferentiate, and divide.

41 ylaminopurine), they reenter the cell cycle, dedifferentiate, and divide.

42 tumorigenic, that they are stable and do not dedifferentiate, and that they do not elicit immune resp

43 Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myoc

44 as quickly down-regulated and disappeared in dedifferentiated ASMC in culture.

45 In this study, we confirmed that transformed dedifferentiated astrocytes and neurons acquired a stem/

46 pmentally stalled neural progenitors or from dedifferentiated astrocytes?

47 Their acinar cells do not dedifferentiate at climax, nor do they down-regulate exo

48 GCPs dedifferentiating at 32 degrees C require both 1-napthal

49 o pathway signaling in vivo is sufficient to dedifferentiate, at very high efficiencies, adult hepato

50 ssing five subtypes, (a) well-differentiated/dedifferentiated, (b) myxoid/round cell, and (c) pleomor

51 mal apical-basal cortical polarity, they can dedifferentiate back into a neuroblast state, functional

52 Instead, they dedifferentiate back into mitotically cycling germ cells

53 ors, which contain cysts that break down and dedifferentiate back to single, mitotically active cells

54 H liver organoids exhibit reduced ability to dedifferentiate back to the biliary state, consistent wi

55 e microenvironment, transit-amplifying cells dedifferentiate, becoming functional stem cells during t

56 Dedifferentiated beta cells reverted to progenitor-like

57 At an early stage, melanoma cells showed a dedifferentiated c-Jun(high)/MITF(low) phenotype, possib

58 quired for survival and proliferation of the dedifferentiated cancer cell.

59 lial cell preservation and conversion into a dedifferentiated cancer stem cell-like phenotype depends

60 t encompasses well-differentiated as well as dedifferentiated cancer types.

61 could be detected in similar assays with the dedifferentiated cell line HepG2.1 or the nonhepatic cel

62 Melanomas can switch to a dedifferentiated cell state upon exposure to cytotoxic T

63 val may be manifested by the production of a dedifferentiated cell with broader potential and that th

64 eration, we find no evidence to suggest that dedifferentiated cells acquire a ductal fate during this

65 , the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling.

66 transcription factors and that diseased and dedifferentiated cells can be returned to normal functio

67 transition, and exogenous PHD2 expression in dedifferentiated cells can restore an epithelial phenoty

68 and three IR-resistant clones isolated from dedifferentiated cells have acquired the ability to prol

69 RNAi-mediated knockdown of Oct4 in dedifferentiated cells led to diminished CSC phenotypes.

70 Upon various challenges, the dedifferentiated cells proliferate and redifferentiate i

71 n organized structure of lineage restricted, dedifferentiated cells that cooperate to regenerate the

72 Dedifferentiated cells were morphologically indistinguis

73 order to perform genetic lineage tracing of dedifferentiated cells while measuring the cellular tran

74 lular matrix, and proliferation of partially dedifferentiated cells, evidence strongly supports the l

75 We characterize these dedifferentiating cells using several lineage-tracing st

76 e can restore chondrocyte gene expression in dedifferentiated chondrocytes grown on plastic.

77 Subsequent culture of the dedifferentiated chondrocytes in 3-dimensional alginate

78 Culture of dedifferentiated chondrocytes in alginate gel induces a

79 as 2-3-fold greater in nuclear extracts from dedifferentiated chondrocytes than in nuclear extracts f

80 in complex formed with nuclear extracts from dedifferentiated chondrocytes were 2-3-fold greater than

81 binding activity between differentiated and dedifferentiated chondrocytes.

82 ition with the BH-3 mimetic ABT-737 rendered dedifferentiated chondrosarcoma cell lines sensitive to

83 The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely r

84 comas, one pleomorphic rhabdomyosarcoma, one dedifferentiated chondrosarcoma, and one malignant perip

85 a survivors; the benefit of chemotherapy for dedifferentiated chondrosarcomas remains questionable; a

86 lanted from the Myh11(R247C/R247C) mice were dedifferentiated compared with wild-type SMCs based on i

87 d TGF-beta down-regulated GKLF expression in dedifferentiated cultured SMCs.

88 d decrease during desiccation, when plastids dedifferentiate/degenerate.

89 adipose tissue and well differentiated from dedifferentiated disease.

90 Human chondrocytes that otherwise rapidly dedifferentiate during in vitro culture also formed nodu

91 Insulin-producing beta cells become dedifferentiated during diabetes progression.

92 ouple of decades that it will be possible to dedifferentiate dysfunctional somatic cells in vivo to a

93 , SMARCA4-deficient thoracic sarcomas(6) and dedifferentiated endometrial carcinomas(7).

94 Conversion of SECs to a capillarized, dedifferentiated endothelium was confirmed at the cellul

95 By single-cell analysis of dedifferentiating enterocytes, we observed the generatio

96 lia promotes BMP7 signaling in repopulating, dedifferentiated epithelia.

97 KC and KCR8-16 mice developed dedifferentiated exocrine pancreata within 2 months of a

98 liferation were seen in conjunction with the dedifferentiated expression of cytokeratins 1, 10 and 5,

99 hat the answer lies in the need for cells to dedifferentiate first, and that what makes them dediffer

100 deleted in adult mice, Schwann cells readily dedifferentiate following peripheral nerve injury and be

101 Human SMCs are first dedifferentiated for 4 days to achieve a vascular progen

102 uggested that cells near the amputation site dedifferentiate forming multipotent progenitors that pop

103 Tumors derived from dedifferentiated germ cells, however, respond to the pro

104 in germline stem cell overproliferation and dedifferentiated germline stem cells.

105 undergoes pX-dependent transformation and a dedifferentiated hepatocyte (AML12) 4pX-1 cell line that

106 addition of hydrated matrix preparations to dedifferentiated hepatocytes.

107 or the survival of HBV variants in gradually dedifferentiating hepatocytes and thus helps prolong vir

108 rs by transient-transfection analysis in the dedifferentiated hepatoma cell line, HepG2.1.

109 plastic tissue culture flasks as monolayers (dedifferentiated HFC cultures).

110 ferentiation that was also down-regulated in dedifferentiated hfRPE cells.

111 he RPE, were significantly down-regulated in dedifferentiated hfRPE cells.

112 ted primary human fetal RPE (hfRPE) cells to dedifferentiated hfRPE cells.

113 8 mm), node negative in 93.4% of cases, and dedifferentiated (high-grade cancer) in 41.7% of cases a

114 Dedifferentiated histologic subtype and the need for con

115 Risk of recurrence is high for patients with dedifferentiated histology or retroperitoneal location.

116 The exocrine-enriched cells rapidly dedifferentiated in culture and grew as a mesenchymal mo

117 decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in cu

118 etic marks, and the mature B cells partially dedifferentiated, induced RAG-1 and -2 along with certai

119 to maintain VSMC quiescence and reverse the dedifferentiating influence of PDGF is mediated via the

120 ence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferenti

121 tially dispensable but becomes essential for dedifferentiated intermediates to transit to ground stat

122 city of bryophytes, the ability of a cell to dedifferentiate into a meristematic state (analogous to

123 hepatocytes in culture have the capacity to dedifferentiate into a population of adult liver progeni

124 that adult mouse cardiomyocytes were able to dedifferentiate into cardiac progenitor-like cells (CPCs

125 t adult beta cells retain plasticity and can dedifferentiate into embryonic fates or adopt alternate

126 hacrylate), and from chondrocytes induced to dedifferentiate into fibroblast-like cells by passage in

127 (via a sequence of genetic alterations), to dedifferentiate into hepatocyte precursor cells (which t

128 Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-produ

129 to induce terminally differentiated cells to dedifferentiate into multipotent proliferative cells wit

130 nd Neurog1+ specified neuronal precursors to dedifferentiate into multipotent stem/progenitor cells t

131 expected plasticity of mature hepatocytes to dedifferentiate into progenitor cells in culture, and th

132 a subset of Muller cells to proliferate and dedifferentiate into RPCs.

133 This capacity of committed cells to dedifferentiate into stem cells may have a more general

134 y enlarged, disorganized, and in some cases, dedifferentiated into a callusoid mass.

135 strated that the luminal secretory cells had dedifferentiated into basal stem cells.

136 r hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subse

137 Single secretory cells clonally dedifferentiated into multipotent stem cells when they w

138 glia (MG) that respond to retinal injury by dedifferentiating into a cycling population of retinal p

139 departs from that assumption, spontaneously dedifferentiating into stem-like cells.

140 This is consistent with EZH2-driven dedifferentiated invasive states associated with treatme

141 pe, we engineered MDA-MB-231 cells, a highly dedifferentiated, invasive breast cancer cell line, to e

142 lanoma cells have the ability to switch to a dedifferentiated, invasive phenotype in response to mult

143 f the mRNA was also pronounced in the dorsal dedifferentiating iris and the regenerating lens.

144 amming, the propensity of committed cells to dedifferentiate is inversely correlated to their state o

145 have a similar expression pattern to that of dedifferentiated islets.

146 compatible either with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRA

147 Many dedifferentiated, late-stage tumors are resistant to gro

148 Dedifferentiated liposarcoma (DDLPS) is a highly maligna

149 Dedifferentiated liposarcoma (DDLPS) is frequently diagn

150 ecimens of WDLPS, and of the closely related dedifferentiated liposarcoma (DDLPS) subtype, revealed i

151 es substantially recover the leiomyosarcoma, dedifferentiated liposarcoma (DDLPS), and synovial sarco

152 and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated

153 e well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS), both characterized

154 tissue, well-differentiated liposarcoma, and dedifferentiated liposarcoma by both deep sequencing of

155 In the human dedifferentiated liposarcoma cell line (LS141) and the p

156 assigned an important role in the growth of dedifferentiated liposarcoma cell lines.

157 ially induces apoptosis and growth arrest in dedifferentiated liposarcoma cells compared with normal

158 Extracellular vesicles derived from dedifferentiated liposarcoma cells induce oncogenic prop

159 Restoring miR-143 expression in dedifferentiated liposarcoma cells inhibited proliferati

160 iated pleomorphic sarcoma and pleomorphic or dedifferentiated liposarcoma of the extremity, which est

161 d checkpoint pathways in well-differentiated/dedifferentiated liposarcoma provides several possible n

162 Dedifferentiated liposarcoma represents focal progressio

163 Multivariate analysis showed that dedifferentiated liposarcoma subtype was associated with

164 Retroperitoneal dedifferentiated liposarcoma was associated with an 83%

165 logies were well-differentiated liposarcoma, dedifferentiated liposarcoma, and leiomyosarcoma.

166 ased knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4,

167 ograft models from surgically resected human dedifferentiated liposarcoma.

168 or its targets may have therapeutic value in dedifferentiated liposarcoma.

169 with undifferentiated pleomorphic sarcoma or dedifferentiated liposarcoma.

170 ng seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma.

171 in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

172 d in > 90% of well-differentiated (WDLS) and dedifferentiated liposarcomas (DDLS).

173 More than 90% of well-differentiated or dedifferentiated liposarcomas (WD/DDLS) have CDK4 amplif

174 Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for ap

175 ned over 40 miRNAs that were dysregulated in dedifferentiated liposarcomas in both the sequencing and

176 hereas only the differentiated components of dedifferentiated liposarcomas were immunohistochemically

177 iposarcomas, 44 (25.6%) were reclassified as dedifferentiated liposarcomas.

178 -associated neochromosomes from well- and/or dedifferentiated liposarcomas.

179 the catalytic subunit alpha2, is induced in dedifferentiated liver.

180 localisation remained evident in apparently dedifferentiated LNCaP cells.

181 of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common.

182 The Ad/N1ICD LPS resembles human dedifferentiated LPS in histological appearance, anatomi

183 ch inhibition suppresses the growth of human dedifferentiated LPS xenografts.

184 LR was most common in dedifferentiated LPS, in which it occurred early (24%, 3

185 ifferentiate first, and that what makes them dedifferentiate may be the presence of thrombin in combi

186 The dedifferentiated melanoma cells acquired features associ

187 The dedifferentiated melanoma cells showed significantly dec

188 In the dedifferentiated mesenchymal CT26 cells, TGFbetaRII-dn c

189 Muller glia in adult mice can be induced to dedifferentiate, migrate, and generate new retinal neuro

190 uro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4(+) T cel

191 ponsiveness of renal epithelial cells to the dedifferentiating morphogenic signals of hepatocyte grow

192 Compared to parental cardiomyocytes, dedifferentiated mouse cardiomyocyte-derived CPCs (mCPCs

193 and that they were induced in proliferating, dedifferentiated Muller glia.

194 Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 quiescent satellite

195 nts >/= 18 years with advanced or metastatic dedifferentiated, myxoid/round cell, or pleomorphic LPS

196 riovenous fistula samples after occlusion by dedifferentiated neointimal VSMC.

197 We detected this dedifferentiated neural crest subpopulation in all estab

198 and, more significantly, these cells do not dedifferentiate nor acquire macrophage-like characterist

199 ues as to how adult beta cells can partially dedifferentiate or become reprogrammed into other islet

200 eased cell death, suggesting that otic cells dedifferentiate or redifferentiate as other cell type(s)

201 xpressed with keratins, thus presenting as a dedifferentiated or interconverted (between epithelial a

202 e frequently co-mutated in highly aggressive dedifferentiated or undifferentiated endometrial carcino

203 firmed that new bone cells do not arise from dedifferentiated osteoblasts under these conditions.

204 Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly re

205 dence that Notch signaling is reactivated in dedifferentiated pancreatic cells.

206 Prolonged Notch activation within dedifferentiated parietal cells eventually enhances cell

207 GCPs cultured at 38 degrees C without ABA dedifferentiate partially but do not divide.

208 % cell death, and surviving RPTCs acquired a dedifferentiated phenotype (e.g. elongated morphology an

209 de that ERalpha activation switched SMC to a dedifferentiated phenotype and may contribute to plaque

210 C/R247C) SMCs to a Rho activator rescued the dedifferentiated phenotype of the SMCs.

211 lved in this process, wherein they express a dedifferentiated phenotype that transiently resembles ne

212 resulted in the opposite effect and led to a dedifferentiated phenotype via a different G protein pat

213 Adenovirus transformed cells have a dedifferentiated phenotype.

214 LK1 overexpression induces clonogenicity and dedifferentiated phenotypes in hepatoma cells.

215 tch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

216 n of these genes was readily observed in the dedifferentiating pigmented epithelial cells, and the le

217 together with previous reports showing that dedifferentiated Pkd1-deficient cells express lower p53

218 e vegetative nucleus of pollen grains and in dedifferentiated plant cell cultures.

219 Human metastatic melanoma cells express a dedifferentiated, plastic phenotype, which may serve as

220 ynovial sarcomas (SySa), well-differentiated/dedifferentiated/pleomorphic and myxoid liposarcomas (ML

221 markedly decreased in the proliferating and dedifferentiated podocytes of mice with anti-glomerular

222 s impaired is thought to be mediated by oval/dedifferentiated progenitor cells, which replenish the h

223 lls originate from normal stem cells or from dedifferentiated progenitor cells.

224 eIF4E is up-regulated in these dedifferentiating progenitors, where it forms a feedback

225 f insulin and FGF2 stimulated Muller glia to dedifferentiate, proliferate, and generate new neurons.

226 to the chicken retina causes Muller glia to dedifferentiate, proliferate, express transcription fact

227 rnate between nondividing differentiated and dedifferentiated proliferating states in vivo.

228 recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from

229 type from a quiescent contractile state to a dedifferentiated, proliferative and migratory state duri

230 escent vascular smooth muscle cells assume a dedifferentiated, proliferative phenotype in response to

231 topic p-Creb expression/cAMP signaling marks dedifferentiated proximal tubular cystic segments.

232 In conclusion, dedifferentiated proximal tubule cells effect proximal t

233 im1+ cells, indicating that acutely injured, dedifferentiated proximal tubule cells, rather than fixe

234 high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after

235 9 markers of immature nephron structures and dedifferentiated proximal tubules after acute kidney inj

236 e cells accumulated and were associated with dedifferentiated proximal tubules.

237 ss of retinal neurons, Muller glia partially dedifferentiate, re-express neuroepithelial markers and

238 xpand 20- to 30-fold, regenerate cell walls, dedifferentiate, reenter the cell cycle, and divide.

239 5- to 6-fold; they do not regenerate walls, dedifferentiate, reenter the cell cycle, or divide.

240 ion constitutes an active mechanism allowing dedifferentiated regenerating cells to scatter on denude

241 C3 was expressed in the dedifferentiated regeneration blastema and in the rediff

242 pe I transmembrane glycoprotein expressed on dedifferentiated renal proximal tubule epithelial cells

243 PDL1 expression is increased in sarcomatoid dedifferentiated renal tumours, which suggests that pati

244 es, primary human hepatocytes (PHHs) rapidly dedifferentiate, resulting in loss of hepatic functions

245 hwann cells degrade their myelin sheaths and dedifferentiate, reverting to a phenotype that supports

246 tgrowth of cultured RPE sheets and prevented dedifferentiated RPE cell proliferation and migration.

247 ved in formation of contractile membranes by dedifferentiated RPE cells and suggest that adjunctive t

248 ibited formation of contractile membranes by dedifferentiated RPE cells on collagen I matrices.

249 ll-cell contact and demonstrate that forcing dedifferentiated RPE cells to adopt cell-cell only conta

250 in nuclear translocation of beta-catenin in dedifferentiated RPE cells.

251 ed to diminish Zeb1 expression and reprogram dedifferentiated RPE cells.

252 Furthermore, wound and distal dedifferentiated Schwann cells constitute different popu

253 Moreover, the authors show that dedifferentiated Schwann cells have the potential to coo

254 00 protein-negative cells in MPNST represent dedifferentiated Schwann cells, which harbor NF1 deletio

255 Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap nerv

256 hickness and axon size distribution but some dedifferentiated SCs and increased macrophage infiltrati

257 enriched in contractile SMCs but reduced in dedifferentiated SMCs.

258 esistant cells associated with a mesenchymal dedifferentiated state displayed elevated responsiveness

259 uscle cells (SMC) from a differentiated to a dedifferentiated state is the critical phenotypic respon

260 r CHAF1A functions in maintaining the highly dedifferentiated state of this aggressive malignancy.

261 ls, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic tran

262 s that RPE are lost rather than persist in a dedifferentiated state.

263 uctive tissues and for sustained growth in a dedifferentiated state.

264 molecular identity of the differentiated and dedifferentiated states in vivo has been elusive.

265 s and progression in the well-differentiated/dedifferentiated subset.

266 differentiated "contractile" phenotype to a dedifferentiated "synthetic" one.

267 of the reprogrammed cancer cells, in essence dedifferentiating them to a state slightly before the me

268 crine pancreas and the intestinal epithelium dedifferentiate to a progenitor state and then rediffere

269 one (TH) induces the tadpole acinar cells to dedifferentiate to a progenitor state.

270 oepithelial and ductal cells, that appear to dedifferentiate to a progenitor-like state before re-dif

271 "Sensing" damaged axons, they dedifferentiate to a progenitor-like state, in which the

272 t players in this process, during which they dedifferentiate to a progenitor/stem cell and promote ax

273 erentiated astrocytes and neurons, which can dedifferentiate to a stem cell-like state upon transform

274 For instance, upon damage cells can dedifferentiate to acquire stem cell potential that allo

275 ial cells of the dorsal iris proliferate and dedifferentiate to form a lens vesicle, which subsequent

276 st proximal to the amputation plane begin to dedifferentiate to form a pool of proliferating progenit

277 In this process, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus r

278 Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcripti

279 within the full spectrum from RAI-refractory dedifferentiated to ATC.

280 etamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells und

281 out the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state

282 neuroendocrine cells, MYC activates Notch to dedifferentiate tumor cells, promoting a temporal shift

283 copy, Gb3Cer and Gb4Cer were mainly found in dedifferentiated tumor cell areas, tumor stroma, and tum

284 RNAs in progestin-mediated expansion of this dedifferentiated tumor cell population.

285 tumors and normal fat specimens identified a dedifferentiated tumor expression signature consisting o

286 early-stage (differentiated) and late-stage (dedifferentiated) tumors.

287 In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and beg

288 myelin sheaths around axons and also rapidly dedifferentiate upon injury.

289 ontrary to the antimotogenic effect of NO in dedifferentiated vascular smooth muscle cells (VSMCs), w

290 In vitro, the expression level of miR-21 in dedifferentiated vascular smooth muscle cells was signif

291 on of the plaque may arise from a subset of "dedifferentiated" vascular smooth muscle cells (SMCs) wh

292 proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in r

293 xpressed highly in differentiated but not in dedifferentiated VSMC.

294 ury, the expression of ACLP increases in the dedifferentiated VSMCs of the neointima in a pattern tha

295 neointimal lesion formation and in cultured dedifferentiated VSMCs.

296 de a novel tool to target gene expression to dedifferentiated VSMCs.

297 se data indicate that mammalian myotubes can dedifferentiate when stimulated with the appropriate fac

298 inally differentiated mammalian myotubes can dedifferentiate when stimulated with the appropriate sig

299 The epithelial cell clone dedifferentiated when grown on plastic; however, the cel

300 , demonstrating their capacity to change and dedifferentiate without any cell divisions.