ライフサイエンスコーパス: dedifferentiation

1 ed with chronic pancreatitis and acinar cell dedifferentiation.

2 he germline could be attributed to defective dedifferentiation.

3 inhibition or knockdown facilitated podocyte dedifferentiation.

4 inhibitor 5-azacytidine, enforces astrocyte dedifferentiation.

5 ntenance, proliferation, differentiation and dedifferentiation.

6 C proliferation and phenotypic switch toward dedifferentiation.

7 set of effector T cells through a process of dedifferentiation.

8 ory cytokine tumor necrosis factor alpha, or dedifferentiation.

9 ty in medulla neurons and prevents them from dedifferentiation.

10 bellum, which points to potential brain cell dedifferentiation.

11 These changes lead to beta-cell dedifferentiation.

12 sion from beta-cell dysfunction to beta-cell dedifferentiation.

13 ersistent inflammation, fibrosis, and acinar dedifferentiation.

14 es cultured for long periods of time undergo dedifferentiation.

15 esting an underlying defect in cardiomyocyte dedifferentiation.

16 l death response is an instrument to achieve dedifferentiation.

17 onstrate that MBNL1 is a suppressor of tumor dedifferentiation.

18 neoplasia, including altered metabolism and dedifferentiation.

19 ong-term enigma has been how injury leads to dedifferentiation.

20 ion by suppressing pluripotency and cellular dedifferentiation.

21 yses reveal transcriptional paths underlying dedifferentiation.

22 to impaired insulin secretion and beta cell dedifferentiation.

23 wn-regulation of Gata6 to induce acinar cell dedifferentiation.

24 olar macrophages, and promoted myofibroblast dedifferentiation.

25 expression correlates with invasiveness and dedifferentiation.

26 gulated, linking malignant transformation to dedifferentiation.

27 by preventing Rokalpha-mediated keratinocyte dedifferentiation.

28 nce low glutamine levels, which promote cell dedifferentiation.

29 nduced EGR1 protein expression and triggered dedifferentiation.

30 eta-cell mass and no indication of beta-cell dedifferentiation.

31 rived microRNA-223 (miRNA-223) reverses VSMC dedifferentiation.

32 sion of genes related to differentiation and dedifferentiation.

33 nflammation and prevent them from undergoing dedifferentiation.

34 ir tissue of origin, probably as a result of dedifferentiation.

35 mechanisms to sense and resist inappropriate dedifferentiation.

36 s both endothelial hyperpermeability and SMC dedifferentiation.

37 NLRC5 binds to PPARgamma and inhibits HASMC dedifferentiation.

38 fferent patterns between explants and during dedifferentiation.

39 t phosphate cotransporter, suggesting apical dedifferentiation accounting for Fanconi syndrome before

40 Furthermore, increased proliferation, dedifferentiation, activation of the DNA damage response

41 l divisions being asymmetric), we found that dedifferentiation acts like a positive selective force i

42 f TGF-beta, leading to renal proximal tubule dedifferentiation, an important event in the pathogenesi

43 observed gene signatures characteristic for dedifferentiation and acquisition of pluripotency marker

44 sential in normal cells for YAP/TAZ-mediated dedifferentiation and acquisition of self-renewing prope

45 ecombinant AZGP1 inhibited kidney epithelial dedifferentiation and antagonized fibroblast activation

46 ding potential to undergo rapid turnover and dedifferentiation and as a source of stem cells.

47 sponse that is initiated by Muller Glia (MG) dedifferentiation and asymmetric cell division to produc

48 avel the molecular mechanisms underlying the dedifferentiation and cell cycle reentry of mouse ACMs.

49 damage response, the inflammatory response, dedifferentiation and cell death in SMCs, and matrix met

50 specific EGFR activation promoted epithelial dedifferentiation and cell-cycle arrest.

51 te the observed relationships between neural dedifferentiation and cognitive performance.

52 vels while preserving beta cells by blocking dedifferentiation and death.

53 ation of MAPK/ERK has been shown to cause SC dedifferentiation and demyelination.

54 neural progenitors (INPs) need to avoid both dedifferentiation and differentiation during neurogenesi

55 tractional forces as key determinants of the dedifferentiation and differentiation stages during repr

56 or suppressor pathway is essential for tumor dedifferentiation and dissemination both in genetically

57 of TSC1 and activation of mTORC1 results in dedifferentiation and dysfunction of the CD and causes h

58 Overexpression of IGF2 led to beta-cell dedifferentiation and endoplasmic reticulum stress causi

59 leads to vascular smooth muscle cell (VSMC) dedifferentiation and enhances responses to IGF-I.

60 jury triggers a regenerative program through dedifferentiation and epicardial activation is a critica

61 icted there would be a stronger link between dedifferentiation and episodic memory performance in old

62 Cirrhosis is associated with cell dedifferentiation and expansion of hepatocholangiolar pr

63 e initial-segment epithelium and resulted in dedifferentiation and extensive epithelial folding.

64 lary muscles, a process that starts with the dedifferentiation and fragmentation of syncytial muscle

65 of Yorkie plays a key role in initiating the dedifferentiation and fragmentation of these muscles.

66 fntb as critical regulators of cardiomyocyte dedifferentiation and heart regeneration in zebrafish.

67 islets in T2D display changes reminiscent of dedifferentiation and highlight SOX5 as a regulator of b

68 rnative-splicing mechanism that drives tumor dedifferentiation and identifies biomarkers that predict

69 r machinery in mice results in cardiomyocyte dedifferentiation and improved heart functionality after

70 ch labeled clones proliferated and expressed dedifferentiation and injury markers.

71 er, they demonstrate that miRNA-223 inhibits dedifferentiation and intimal hyperplasia in diabetic mi

72 lial cells caused ATP depletion, cell death, dedifferentiation and intracellular lipid deposition, ph

73 e kinase Axl causes a TGF-beta switch toward dedifferentiation and invasion of HCC cells.

74 The mechanisms underlying the dedifferentiation and lineage conversion of adult human

75 ugh defective acidification, thereby causing dedifferentiation and loss of reabsorptive capacity of P

76 g function of Pygo2 is important for driving dedifferentiation and malignancy of breast tumors, and l

77 phages amplifies demyelination, Schwann cell dedifferentiation and perturbation of axons.

78 riguingly, NFATc1-Sox2 complex-mediated PDAC dedifferentiation and progression is opposed by antithet

79 last growth factor-2 (FGF-2), can induce the dedifferentiation and proliferation of cultured human po

80 he compliant microenvironment facilitates CM dedifferentiation and proliferation via its effect on th

81 served that mature dermal adipocytes undergo dedifferentiation and redifferentiation under physiologi

82 apoptosis, possibly accompanied by beta-cell dedifferentiation and reduced rates of beta-cell prolife

83 ll apoptosis and necrosis, oxidative stress, dedifferentiation and regenerative cell proliferation, r

84 rent stem-cell markers during injury-induced dedifferentiation and repair.

85 h MUC1-C activates the NuRD complex to drive dedifferentiation and reprogramming of TNBC cells.

86 hemotherapies and targeted therapies through dedifferentiation and signaling adaptation processes.

87 we show that Sox2 is required for initiating dedifferentiation and that inhibition of Ezh2 promotes m

88 s and subjected to long-term culture undergo dedifferentiation and that these cells can be redifferen

89 acts intrinsically in germ cells to activate dedifferentiation and thus replenish lost GSCs during bo

90 plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the contex

91 overexpression of FIR correlates with tumor dedifferentiation and tumor cell proliferation in about

92 pic Notch activation is sufficient to induce dedifferentiation and tumorigenic transformation of matu

93 ory state to a nonsecretory quiescent state (dedifferentiation) and back.

94 moting the disruption of adherens junctions, dedifferentiation, and an epithelial to mesenchymal tran

95 us ensues, leading to beta-cell dysfunction, dedifferentiation, and apoptosis.

96 Prrx1b promotes invasion, tumor dedifferentiation, and EMT.

97 ays in carcinogenesis, such as angiogenesis, dedifferentiation, and invasion.

98 that ocular treatment prevents tumor growth, dedifferentiation, and metastatic disease in some patien

99 The results herein indicate that beta-cell dedifferentiation, and not necessarily endocrine cell lo

100 ulated expression of fibrotic genes, induced dedifferentiation, and orchestrated epithelial cell-cycl

101 s is Aldh1a3, a putative marker of beta-cell dedifferentiation, and other genes associated with beta-

102 miRNAs are important drivers of hepatic dedifferentiation, and our results provide valuable info

103 phages amplifies demyelination, Schwann cell dedifferentiation, and perturbation of axons.

104 RCA1 suppressed TWIST and EMT, inhibited LSC dedifferentiation, and repressed expansion of basal stem

105 uced autophagy, enhanced tumor growth, tumor dedifferentiation, and resistance to TKI therapy.

106 omic alterations associated with sarcomatoid dedifferentiation are poorly characterized.

107 To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the o

108 n are activated, while gene sets involved in dedifferentiation are suppressed.

109 These findings reveal cell dedifferentiation as the principal means for ISC restora

110 atments resulted in a reduction of beta-cell dedifferentiation, as assessed by Foxo1 and Aldh1a3 immu

111 show increased proliferation and anaplastic dedifferentiation, as well as mTORC1 hyperactivation wit

112 ty at the promoters of procontractile versus dedifferentiation-associated genes.

113 ty, while also restoring cell proliferation, dedifferentiation-associated repair and regeneration of

114 P < 0.0001), and increased proliferation and dedifferentiation at the transcriptomic level in advance

115 rogenitor-based mechanism (larval mode) to a dedifferentiation-based one (adult mode) as it transits

116 Dedifferentiation began in middle age, and continued int

117 In summary, dedifferentiation begins relatively early in adulthood a

118 ric and asymmetric divisions), we found that dedifferentiation beyond a critical threshold leads to e

119 Inflammation, cell hypertrophy, and dedifferentiation by the activation of classic pathways

120 Our evidence suggests that human cell dedifferentiation can be achieved through autonomously c

121 In this study, we asked whether beta-cell dedifferentiation can be prevented with diet or pharmaco

122 tion of the FHL2 gene mitigated the podocyte dedifferentiation caused by activated Wnt/beta-catenin s

123 ith PDZ-binding motif activation/expression, dedifferentiation, cell cycle arrest, and renal fibrogen

124 actin, and desmin, and increased markers of dedifferentiation, cellular retinol-binding protein 1, a

125 rk exploring the relationship between neural dedifferentiation, cognition, and age.

126 ponse to investigate the control features of dedifferentiation, combining single cell imaging with hi

127 Dictyostelium cells undergo highly efficient dedifferentiation, completed by most cells within 24 hr.

128 his finding has prompted the suggestion that dedifferentiation contributes to age-related cognitive d

129 workload resulting in beta-cell dysfunction, dedifferentiation, death, and development of type 2 diab

130 It is followed by chloroplast dedifferentiation/degeneration that starts at the end of

131 Mutation of genes induced early in dedifferentiation did not strongly perturb the reversal

132 er propose that the effects of age on neural dedifferentiation do not exclusively reflect detrimental

133 nly facilitates relaxation but also prevents dedifferentiation during atherosclerosis development, re

134 e that Brca1 directly suppresses EMT and LSC dedifferentiation during breast tumorigenesis.

135 determination during normal development and dedifferentiation during disease.

136 Here we show that skeletal muscle dedifferentiation during newt limb regeneration depends

137 nscriptome dynamics during the initiation of dedifferentiation during the first 24 hours of culture.

138 in response to caerulein-induced acinar cell dedifferentiation, early neoplasia, and throughout PDA p

139 ranscriptional control in breast cancer cell dedifferentiation, EMT, and metastasis.

140 he epigenetic landscape, leading to cellular dedifferentiation, enhanced mesenchymal transition, and

141 Finally, besides inducing epithelial dedifferentiation, exogenous TGF-beta1 dose-dependently

142 ithelial cells (i.e., one involving cellular dedifferentiation followed by redifferentiation).

143 long-term PDL induced significant beta-cell dedifferentiation, followed by a time-dependent decrease

144 Schwann cell dedifferentiation from a myelinating to a progenitor-lik

145 obal pattern of cardiomyocyte remodeling and dedifferentiation, hallmarked by myolysis, glycogen accu

146 Consistent with this possibility, dedifferentiation has been reported to negatively correl

147 Recently, beta-cell dedifferentiation has been shown to be an important cont

148 Given the proposed role of dedifferentiation in age-related cognitive decline, we p

149 PRC5B in the regulation of contractility and dedifferentiation in human and murine SMCs in vitro and

150 chromatin basis of cell differentiation and dedifferentiation in intestinal crypts, we discuss here

151 e of reversing MAP2K7Deltaexon2-driven tumor dedifferentiation in MBNL1-low cancer cells.

152 Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones.

153 d attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs.

154 y adulthood, and compositional changes cause dedifferentiation in old age.

155 We also observed formation of PGCCs and dedifferentiation in ovarian cancer specimens from patie

156 gs suggest a fundamental role for osteoblast dedifferentiation in reparative bone formation in fish a

157 ion factors MafA and Pdx1 point to beta-cell dedifferentiation in the absence of pericytes.

158 progression from metabolic inflexibility to dedifferentiation in the natural history of beta-cell fa

159 The recognition of beta cell dedifferentiation in type 2 diabetes raises the translat

160 n sulfide production, and smooth muscle cell dedifferentiation in vitro.

161 er regeneration and possibilities to inhibit dedifferentiation in vitro.

162 th the remarkable ability to promote myotube dedifferentiation in vitro.

163 rk-based theory for previous reports of the "dedifferentiation" in brain activity observed in aging.S

164 ssociated with decreased neural selectivity (dedifferentiation) in category-selective cortical region

165 ems and a loss of functional specificity, or dedifferentiation, in posterior-medial regions.

166 This dedifferentiation includes the acquisition of rapid cell

167 iant elastic matrices induced features of CM dedifferentiation, including a disorganized sarcomere ne

168 Moreover, as a result of severe dedifferentiation, including the loss of human sodium io

169 interstitial fibrosis, evident by epithelial dedifferentiation, increased myofibroblasts, immune cell

170 ells enable a variety of functions including dedifferentiation, innate immunity and adaptive immunity

171 of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, su

172 phila larvae undergo a remarkable process of dedifferentiation into single cells that then fuse to be

173 Dedifferentiation is a critical response to tissue damag

174 Cellular dedifferentiation is a key mechanism driving cancer prog

175 Dedifferentiation is an important process to replenish l

176 Sarcomatoid dedifferentiation is an uncommon feature that can occur

177 Here, we examined whether dedifferentiation is associated with performance in anot

178 Although dedifferentiation is central to tissue repair and stemne

179 This raises the question whether osteoblast dedifferentiation is specific to appendage regeneration,

180 he transcription factor network and cellular dedifferentiation likely mediate terminal liver failure

181 , and nkx6.1 and increased expression of the dedifferentiation markers sox2 and hes1.

182 These dedifferentiation markers were co-expressed with p-Creb

183 tinal regeneration arises from daughter cell dedifferentiation, marking the coming-of-age of the rege

184 nomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the mole

185 Thus, dedifferentiation may play a crucial role, the common mo

186 Our results suggest that dedifferentiation may play an important role in carcinog

187 The identification of pathways involved in dedifferentiation may provide clues to its reversal.

188 Our recent findings point to a dedifferentiation mechanism by which reprogramming trans

189 t neural representations in old age ("neural dedifferentiation"), memory studies have shown that over

190 itching, a pathological process in which SMC dedifferentiation, migration, and transdifferentiation i

191 In line with senescent neural dedifferentiation more generally, our results highlight

192 dermal Par3 inactivation in mice promotes MC dedifferentiation, motility, and hyperplasia and, in an

193 Functionally, aged SCs exhibit impaired dedifferentiation, myelin clearance, and macrophage recr

194 ical role in detoxifying iron during plastid dedifferentiation occurring in embryogenesis and senesce

195 Nicotine induced dedifferentiation of acinar cells by activating AKT-ERK-

196 Loss of Numb resulted in premature dedifferentiation of acinar cells in response to injury

197 ing promotes formation of PanINs by enabling dedifferentiation of acinar cells into duct-like cells t

198 al stimulation in preventing culture-induced dedifferentiation of adult cardiac tissue using rat, rab

199 a-catenin nuclear activity and prevention of dedifferentiation of adult RPE.

200 actor 4alpha(HNF4alpha), possibly indicating dedifferentiation of BECs.

201 betes (T2D) was recently proposed to involve dedifferentiation of beta-cells and ectopic expression o

202 n, we and others have recently proposed that dedifferentiation of beta-cells can explain the slowly p

203 l passing through a transient, nonpathologic dedifferentiation of beta-cells to a pancreatic polypept

204 ay for immune escape, namely immune-mediated dedifferentiation of breast cancer cells, which is assoc

205 vidence that sarcomatoid elements arise from dedifferentiation of carcinomatous ccRCCs and implicate

206 reticulum stress, columnar cell lesions, and dedifferentiation of CD cells with loss of aquaporin-2 a

207 conclude that OPN is an important player in dedifferentiation of cells during tumor formation, hence

208 rdial activation, epicardial activation, and dedifferentiation of compact myocardial cells as causati

209 ose an oncogenic module that is coopted upon dedifferentiation of early-born intermediate progenitors

210 Low shear stress induces dedifferentiation of EC through a process termed endothe

211 -lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+)

212 This process, which involves the dedifferentiation of epithelial tumor cells towards a mo

213 Dedifferentiation of fibroblasts to intermediate CD34(+)

214 inase (ERK) pathway regulates a mechanism of dedifferentiation of GBM cells into a stem-like state ex

215 fines an ERK-mediated molecular mechanism of dedifferentiation of GBM cells into a stem-like state, e

216 ture does not reflect progenitor origin, but dedifferentiation of hepatocyte-derived tumor cells.

217 alcoholic hepatitis (AH) is characterized by dedifferentiation of hepatocytes and loss of mature func

218 g persistent HBV replication, augmenting the dedifferentiation of hepatocytes by inhibiting HNF4alpha

219 CD34(+) progenitors were generated after the dedifferentiation of human adult dermal fibroblasts by o

220 Taken together, our data show that the dedifferentiation of human dendritic cells effectively s

221 ease in type II neuroblasts results from the dedifferentiation of imINPs due to loss of Earmuff at la

222 e Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of INPs back into type II neuroblasts.

223 s both the premature differentiation and the dedifferentiation of INPs by regulating the expression o

224 -specific transcription factor that prevents dedifferentiation of INPs into neuroblasts.

225 -to-mesenchymal transition (EMT) and induces dedifferentiation of LSCs, which associate closely with

226 Bnc1) modulates TGF-beta1-induced epithelial dedifferentiation of mammary epithelial cells.

227 n P1-transcribed mRNA, whereas Wnt3a-induced dedifferentiation of mature adipocytes produced reciproc

228 Cancer may arise from dedifferentiation of mature cells or maturation-arrested

229 It frequently requires the dedifferentiation of mature cells to a condensed mesench

230 Moreover, loss of p53 facilitates dedifferentiation of mature hepatocytes into nestin-posi

231 Here, we show that dedifferentiation of mature osteoblasts is not restricte

232 ssion through histone modification, prevents dedifferentiation of mature somatic cells in Arabidopsis

233 F-beta1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of alpha-smooth mus

234 examination of the CNS tumour can confirm a dedifferentiation of NEN in the direction of a neuroendo

235 n and in some non-mammalian vertebrates, the dedifferentiation of osteoblasts may contribute to skele

236 precede most changes in coding genes during dedifferentiation of PHHs, and we speculated that these

237 This ability involves dedifferentiation of post-mitotic cells into progenitors

238 entry of cardiomyocytes into the cell cycle; dedifferentiation of pre-existing cardiomyocytes, which

239 n both stem cells and progenitors, including dedifferentiation of progenitor cells to a stem cell-lik

240 In contrast, Yap knockdown prevents the dedifferentiation of secretory cells into stem cells.

241 thology is linked to aberrant activation and dedifferentiation of specialized memory networks that is

242 enes and, similar to WNT3a, promoted partial dedifferentiation of the cells and the induction of a my

243 Dedifferentiation of these cells has been suggested to o

244 -generated hypoxia in the liver causes rapid dedifferentiation of tumor cells into immature CSCs with

245 lar injury that results in proliferation and dedifferentiation of vascular smooth muscle cells (SMCs)

246 While multiple studies have focused on dedifferentiation of VSMCs, prevention of VSMC-mediated

247 turn, repressed PDGFR expression to promote dedifferentiation of wild-type Pygo2 mammary epithelial

248 his, we mathematically modeled the effect of dedifferentiation on carcinogenesis.

249 t evidence indicates that age-related neural dedifferentiation, operationalized in terms of neural se

250 ogenitor cell expansion without affecting MG dedifferentiation or progenitor cell generation.

251 cardiomyocyte marker expression loss due to dedifferentiation or significant contribution from cardi

252 f Myc and reported enhanced beta-cell death, dedifferentiation, or the formation of insulinomas if co

253 ion of Nrg1 expression induces cardiomyocyte dedifferentiation, overt muscle hyperplasia, epicardial

254 ctopic overexpression partly phenocopies the dedifferentiation phenotype of PRC2 mutants.

255 It has recently been proposed that dedifferentiation/plasticity towards other endocrine phe

256 tively target neural tumours that grow via a dedifferentiation process involving large cell size incr

257 he underlying mechanisms and stalling of the dedifferentiation process would be highly beneficial to

258 at these modulations could drive the hepatic dedifferentiation process.

259 tures seen in children, indicating a partial dedifferentiation process.

260 lar behavior during both differentiation and dedifferentiation processes.

261 uggest that AK144841 could contribute to the dedifferentiation program of tumor-forming keratinocytes

262 tumor cells exploit cellular plasticity and dedifferentiation programs to avoid immune surveillance,

263 The results fully define AKI-associated dedifferentiation programs, potential pathologic ligand-

264 to-insulin' delta-cell conversion, involving dedifferentiation, proliferation and re-expression of is

265 bly of membrane attack complex promotes cell dedifferentiation, proliferation, and migration in addit

266 pression programs that promote cardiomyocyte dedifferentiation, proliferation, and protrusion into th

267 ts its tumorigenic effects by promoting cell dedifferentiation, proliferation, invasiveness, and diss

268 mediate DDLPS-associated aggressiveness and dedifferentiation properties.

269 thermore, it is not known whether fibroblast dedifferentiation recapitulates the generation of multip

270 CE STATEMENT Aging is associated with neural dedifferentiation-reduced neural selectivity in "categor

271 y significant variance in measures of neural dedifferentiation reflects both age-dependent and age-in

272 types, providing a powerful system to study dedifferentiation/regeneration processes in independent

273 in 1968, the mechanisms driving sarcomatoid dedifferentiation remain poorly understood, and informat

274 Our analysis reveals novel facets of the dedifferentiation response, including acquisition of mes

275 These regulatory features may contribute to dedifferentiation responses during regeneration.

276 ion in VSMCs in non-diabetic mice results in dedifferentiation, SHPS-1 activation, and aberrant signa

277 their target transcripts in maize SE at the dedifferentiation step using VS-535 zygotic embryos coll

278 mutants prevented and even rescued tenocyte dedifferentiation suggesting a continuous and cell auton

279 transformation, Ad/N1ICD adipocytes undergo dedifferentiation that leads to lipodystrophy and metabo

280 In mature duct cells, Brg1 inhibits the dedifferentiation that precedes neoplastic transformatio

281 ts astrocyte differentiation and can trigger dedifferentiation to a proliferative NS cell state.

282 atus underlies intestinal cell diversity and dedifferentiation to restore ISC function and intestinal

283 Features of epithelial dedifferentiation towards a mesenchymal phenotype are ob

284 and provided by processes including cellular dedifferentiation, transdifferentiation, and reprogrammi

285 Their contributions to stem cell-like dedifferentiation, tumor aggressiveness, and therapy res

286 RPE dedifferentiation was indicated by reduced pigmentation,

287 Gene expression during dedifferentiation was predominantly a simple reversal of

288 Evidence of age-related dedifferentiation was subtle at perception but more sali

289 F4, a transcription factor that induces VSMC dedifferentiation, was up-regulated in IRS-1(-/-) mice,

290 h-factor responsiveness in mature neurons by dedifferentiation, we overexpressed Lin28 in the retina.

291 cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body.

292 additional factors such as inflammation and dedifferentiation, which associate with renal injury and

293 ding RNAs, in particular, miRNAs, in hepatic dedifferentiation, which can aid the development of more

294 uble cystine accumulation induces apical PTC dedifferentiation, which causes transfer of the harmful

295 sition (EMT), a process combining tumor cell dedifferentiation with acquisition of stemness features.

296 ion or inhibition of its function results in dedifferentiation with characteristics of an epithelial-

297 eceptor-gamma in adipocytes, consistent with dedifferentiation with loss of lipid and Oil Red O stain

298 un, which interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine respons

299 AKI induced proximal tubule dedifferentiation, with a pronounced nephrogenic signatu

300 generation is explained nearly completely by dedifferentiation, with contributions from absorptive an