ライフサイエンスコーパス: deeply

1 s and geographical regions was explored more deeply.

2 er to understand the biology of cancers more deeply.

3 ork and show that ClpXP can easily degrade a deeply 3(1)-knotted protein.

4 our NIH intramural women scientists who care deeply about scientific progress and the progress of wom

5 ur study also showed that recurrent droughts deeply affected vegetation productivity throughout the o

6 isual context in which a body is encountered deeply affects its perceptual analysis.

7 lain how these aspects of our physiology are deeply and inextricably connected.

8 pectrometry (MS)-based methods to delve more deeply and precisely into the biochemical state of cells

9 and posterior cortex when subjects were more deeply anesthetized and likely unarousable.

10 iffusion of axon plasma membrane proteins is deeply anisotropic, as longitudinal diffusion is of diff

11 ed dentin at the dentin surface and extended deeply around dentinal tubules.

12 swarm faster and produce colonies with more deeply branched swarming fronts than the wild type or th

13 increased co-metabolic interactions in more deeply branching clades.

14 and test the bifurcating hypothesis between deeply branching lineages based on genomic data.

15 urcating diversification apply, even between deeply branching lineages of the conifer genus Picea.

16 nd extracted 29 new genomes, including three deeply branching lineages.

17 The mer operon of the deeply branching thermophile Thermus thermophilus HB27 e

18 Two deeply-branching mcrA clades related to Bathyarchaeota w

19 e for imaging neurons and neural activity in deeply buried brain structures.

20 n technique for which the initial state is a deeply buried core level.

21 ppears driven by diagenetic strengthening of deeply buried fault-forming sediments, contrasting with

22 ose ions are tightly coordinated by rRNA and deeply buried in the ribosome.

23 ch binds six sulfate anions; two of them are deeply buried inside the container structure while four

24 nomer, the ADAMTS13 cleavage site is located deeply buried inside the VWF A2 domain.

25 alpha/beta architecture, with the acyl chain deeply buried into a hydrophobic pocket that runs perpen

26 ally unstable upon purification, and possess deeply buried ligand-binding sites.

27 MS retains native-like avidin tetramers with deeply buried solvent particles; (2) applying high activ

28 Identification of relevant inferences is a deeply challenging problem, and the most important contr

29 esource derived from healthy organ donors to deeply characterize human B-cell compartments across mul

30 h would help to decipher this complexity, to deeply characterize the pathophysiology of the disease a

31 past of rainforest hunter-gatherers has been deeply characterized, important aspects of their history

32 ndings have elicited substantial interest in deeply characterizing the diversity, interrelationships

33 -was optically monitored by observation of a deeply colored Fe[(SCN)(H(2)O)(5)](2+) complex that form

34 policies in the US have left many scientists deeply concerned about their future and many American-ba

35 already in infancy, but is nonetheless more deeply connected to other magnitudes through adulthood t

36 he target genes that they regulate are often deeply conserved across species, the connections between

37 VMP family massively expanded from a single, deeply conserved adam28 disintegrin and metalloproteinas

38 tween lampreys and gnathostomes can identify deeply conserved and evolutionarily flexible features of

39 a mechanism that regulates the activity of a deeply conserved and highly dosage-sensitive family of R

40 lecular mechanisms of parental care might be deeply conserved and might not be sex-specific, and sugg

41 from the environment via TRPM channels is a deeply conserved aspect of egg activation.

42 somatosensory neurite ensheathment is thus a deeply conserved cellular process that contributes to th

43 transferases (HPATs) are members of a small, deeply conserved family of plant-specific glycosyltransf

44 The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that reg

45 changes became necessary for the regulator's deeply conserved function, thereby poising the regulator

46 siological ground plans, genetic toolkits of deeply conserved genes, evolutionary changes in protein-

47 , we identify a set of wing-associated genes deeply conserved in the pterygote insects and find trans

48 lian outgroups has the potential to identify deeply conserved lineage specification and pluripotency

49 ive endoderm and trophectoderm, and identify deeply conserved lineage-specific markers that pre-date

50 species-specific regulation of aging reveals deeply conserved mechanisms of longevity and population

51 is path-integration behavior may represent a deeply conserved navigational capacity in insects [6, 7]

52 LV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit(1,2).

53 We identify a deeply conserved Pou3f3 arch enhancer present in humans

54 characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is c

55 e module of the Mediator complex, which is a deeply conserved regulator of transcription in eukaryote

56 unction for RGH3/ZRSR2 in U12 splicing and a deeply conserved role for the minor spliceosome to promo

57 ural coloration, and show that optix plays a deeply conserved role in butterfly wing pattern developm

58 We found evidence of deeply conserved susceptibility across the avian tree; h

59 enetic processes involved in development are deeply conserved within the animal kingdom.

60 Moreover, most piRNA pathway proteins are deeply conserved, but different animals employ remarkabl

61 As AChE is deeply conserved, widely expressed outside of the nervou

62 , remove, and read histone modifications are deeply conserved.

63 Our data constitute a deeply contextualized portrait of population-wide burden

64 promised, the apical plasma membrane becomes deeply convoluted, and nonuniform cell behaviors begin t

65 stresses generated by molecular motors, and deeply couples mechanics and chemistry at high spatial r

66 Through coherent adiabatic association in a deeply degenerate mixture of a rubidium Bose-Einstein co

67 ive optical detector is presented based on a deeply depleted graphene-insulator-semiconducting (D(2)G

68 sistor (GFET) by carriers generated within a deeply depleted low-doped silicon substrate.

69 GluN1/GluN3 receptors produce glycine-gated deeply desensitising currents that are insensitive to gl

70 We identified two deeply diverged and well-supported reciprocally monophyl

71 complex phenotypes is within reach, even in deeply diverged species.

72 With Cylindraspis a deeply divergent clade of tortoises became extinct that

73 izii is composed of seven well-supported and deeply divergent clades (I: Antarctica and South Georgia

74 ans carry hundreds of gene variants from two deeply divergent Denisovan lineages that separated over

75 Extant land plants consist of two deeply divergent groups, tracheophytes and bryophytes, w

76 ut it has been unclear until now whether the deeply divergent maize lineages underwent any subsequent

77 ibbean during the Archaic Age, derive from a deeply divergent population that is closest to Central a

78 One individual carried the deeply divergent Y chromosome haplogroup A00, which toda

79 We demonstrate, however, that the deeply divergent, autochthonous African component which

80 aphically disparate groups or a lineage more deeply diverging than that of the San contributing more

81 nsmit rapid excitatory currents that depress deeply during repetitive activity, driving phasic spike

82 This study deeply elucidates a link between prolidase activity and

83 pread multifunctional polarity regulators is deeply embedded in the cell cycle circuitry.

84 However, older adults deeply embedded in the complete network tend to maintain

85 ionship with their host; despite often being deeply embedded in the dermis, no other species has been

86 as spectroscopy and lifetime measurements of deeply embedded materials, which cannot be matched using

87 Additionally, even deeply embedded nanoparticles can reversibly exchange ox

88 knotted mitochondrial proteins and the most deeply embedded protein knot discovered so far.

89 One of the triflate anions is deeply embedded within the cavity of the trinuclear pill

90 ed receptors (GPCRs) are situated around and deeply embedded within the central pocket formed by thei

91 Younger generations have deeply embraced information technology and multitasking

92 As blood vessels in bone are deeply encased in the calcified matrix, imaging techniqu

93 It is a deeply engrained notion that the visual pigment rhodopsi

94 proven difficult, as timing on this scale is deeply entangled with other behaviors.

95 attitudes, even when these attitudes may be deeply entrenched and socially and politically volatile.

96 It is so deeply entrenched in our nature that it can be seen at t

97 etoresistance and the planar Hall effect are deeply entwined with ferromagnetism.

98 on of film-based electronics and devices are deeply established in the framework of native solid subs

99 NAs that produce peptides, including several deeply evolutionarily conserved and significantly Pi-reg

100 Here, we used network methods to more deeply examine the influence of social context in stroke

101 stly solitary (n = 8/8), large (n = 5/8) and deeply excavated (n = 8/8).

102 to medium (n = 13/15), solitary (n = 15/15), deeply excavated lesions (n = 11/15) with choroidal lacu

103 ngle-cell whole-exome sequencing (scWES) has deeply expanded and sharpened our knowledge of cancer ev

104 In this work, we aim to deeply explore: (1) associations between microstructure

105 re by light and electron microscopy and have deeply explored the salivary transcriptome and proteome.

106 ve during much of the Arctic winter, despite deeply frozen soils.

107 Yet precisely how Pax6 achieves this deeply homologous function is poorly understood.

108 st the pandemic may represent the triumph of deeply human instincts over optimal policy.

109 I am deeply humbled and honored to receive the American Socie

110 Indeed, it is known to remain mainly in deeply hydrotreated samples, validating previous observa

111 h only a cursory interest in blooms as those deeply immersed in the challenge of understanding the te

112 ed defects in grain boundaries of manganites deeply impact their functional properties by boosting th

113 through a series of range expansions, which deeply impacted genetic diversity in newly settled areas

114 n Mtb keto-MA content and size distribution, deeply impacting the production of full-size molecules.

115 ce of transposition-competitive variants can deeply impair TE dynamics and gives clues to the extraor

116 to simulate the performance and response of deeply implanted devices to US stimulation and composed

117 eters of bone using a combination of WGS and deeply imputed genotype data, we have identified five no

118 were then meta-analysed with those from two deeply imputed GWAS replication cohorts (n = 1610 and 13

119 systemic inflammatory responses originating deeply in soft tissues.

120 and circadian factors can be considered more deeply in the future when integrating with well-establis

121 The additional pyridine ring of ZnTerp binds deeply in the major binding pocket and, in contrast to Z

122 motherapeutic efficacy has not been examined deeply in whole organism models.

123 l suggests that this receptor can exist in a deeply inactivated state, not responsive to ATP, and tha

124 et of sediment-infilled depressions that are deeply incised into bedrock that we interpret as giant p

125 by an inland-directed surge that inundated a deeply incised river channel before accretion of the fin

126 The pathology revealed diffusely and deeply infiltrating tumour cells extending through the d

127 e propose that novel mtDNA-encoded genes can deeply influence bivalve sex determining systems and the

128 a range from parasitism to mutualism and may deeply influence both partners' fitness.

129 Belowground biota can deeply influence plant invasion.

130 of acute respiratory distress syndrome could deeply influence results from each method.

131 conceptualized saturable surface binding and deeply influenced physical biochemistry.

132 relationship between effort and rewards are deeply ingrained in various societal attitudes.

133 in the interface region and is slightly more deeply inserted in 1-myristoyl-2-hydroxy-sn-glycero-3-ph

134 similar for all guests with the ammonium ion deeply inserted into the polyaromatic cavity and its NH(

135 l that LD targeting of these motifs requires deeply inserted tryptophans that have lower free energy

136 ne Expression Omnibus (GEO) NGS content into deeply integrated gene expression and chromatin data, ma

137 lthough lymphatic structures are often found deeply integrated into the fabric of adipose tissue, the

138 rmation, on both local and global scales, is deeply integrated into the ventral (temporal) object-pro

139 At the top-level, this suggests a deeply integrated network; however, regional grouping of

140 Naturally and deeply integrated observations of population dynamics wo

141 s in sensory cortices are more naturally and deeply integrated than any current neural population rec

142 Deeply integrated with field case-based surveillance, it

143 )O(2) and (3)CDOM* can be complicated by the deeply interconnected nature of these two reactive speci

144 we call neural collapse (NC), involving four deeply interconnected phenomena.

145 la animal tissues and cultured cells to more deeply interrogate the impact of dKDM4A on chromatin cha

146 pounds function as central messengers within deeply intertwined signaling networks.

147 clear that computation/simulation is anyway deeply intertwined with theory-building in what we do, o

148 clear that computation/simulation is anyway deeply intertwined with theory-building in what we do.

149 nosaurus rex stand out for habitually biting deeply into bones, pulverizing and digesting them.

150 As with any field that delves deeply into innate signaling, obstacles of reagent purit

151 e indicate that the Syt-7 C2B domain inserts deeply into membranes as part of the C2AB tandem, simila

152 ion time of Ppa (up to 13-fold), penetrating deeply into multicellular tumor spheroids and accumulati

153 id headgroups and one in which it penetrates deeply into the bilayer.

154 hydrocarbon chain, and it doesn't penetrate deeply into the bilayer.

155 oduced widespread encephalitis that extended deeply into the brain parenchyma.

156 om maps demonstrated that CBH extending more deeply into the cerebellum predicted adverse motor, visu

157 inging a three-dimensional electronic system deeply into the EQL can be difficult however, since it r

158 NBS nanoparticles are capable of penetrating deeply into the hypoxic and acidic cores of 3D spheroid

159 , contributions by smaller teams search more deeply into the past, are viewed as disruptive to scienc

160 pled to plasmonic nanocavity arrays reaching deeply into the Purcell regime with Purcell factors (F P

161 ended helix with its amino terminus inserted deeply into the receptor transmembrane domain (TMD), whi

162 Our experiments probe deeply into the regime where theory has long predicted a

163 rganize into two long helices that penetrate deeply into the regulatory RCK domains, thus connecting

164 vations, have enabled investigators to delve deeply into the structures that mediate episodic memory,

165 y a strong multiphoton laser that penetrates deeply into the tissues of living, anesthetized mice, al

166 The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through u

167 erations of splice enhancers or silencers or deeply intronic events.

168 was robust to deletion of any intergenic or deeply intronic non-coding region, indicating that proxi

169 Lesions judged to be deeply invasive by an expert panel will be excluded.

170 sed on a cross-species similarity search and deeply investigate the evolution of NumtS in mammals.

171 ch as CNTs, and hence lays the foundation to deeply investigate the nonlinear mode coupling in these

172 oward the cleavage of phosphoric diesters is deeply investigated both with kinetic experiments and DF

173 cartilage to excessive mechanical loading is deeply involved in the pathogenesis of osteoarthritis.

174 ed controversial since the identification of deeply knotted proteins nearly two decades ago.

175 At the second stage, those deeply learned features along with the pivotal limited d

176 ffort is a common phenomenological construct deeply linked to volition and self-control.

177 er close to the conductance band's bottom or deeply localized in the forbidden gap.

178 articularly for stress management, targeting deeply located limbic areas involved in stress processin

179 with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared

180 ections for selected central and right-sided deeply located tumors.

181 generating, curating and publicly releasing deeply measured molecular data from thousands of tumor s

182 PWV and AI are deeply modified in SCD patients in comparison with healt

183 P<0.001), whose secondary structure appeared deeply modified.

184 tures of the MIT effect are evident from the deeply modulated ferromagnetic resonance of Py due to th

185 nd experimental observations in systems with deeply nanoscale feature sizes, which are typically evid

186 ain because the resting state exists only at deeply negative membrane potentials.

187 tions establish that glyptodonts are in fact deeply nested within the armadillo crown-group, represen

188 is suggests that *Lessiniabatis gen. nov. is deeply nested within the benthic stingrays (Dasyatoidea)

189 In addition, M. conductrix is deeply nested within the Chlorella clade, suggesting tha

190 of the three helices penetrates the micelle deeply or makes significant tertiary contacts to the oth

191 complexes are nonimmunogenic, are freely and deeply penetrant to human OA cartilage, and persist in c

192 We show that it efficiently and deeply penetrated human cartilage to deliver its siRNA c

193 cells and the antibodies they produce have a deeply penetrating influence on human physiology.

194 canopy to take greater advantage of the more deeply penetrating light.

195 The NeuroDev study will deeply phenotype cognition, behavior, dysmorphias, and n

196 d be identified through factor analysis of a deeply phenotyped clinical sample.

197 (MAGI2) through whole-exome sequencing of a deeply phenotyped cohort of patients with congenital, ch

198 a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on

199 In conclusion, using a deeply phenotyped cohort, we delineate a pathway from po

200 s illustrates the biological value of large, deeply phenotyped cohorts of unselected populations coup

201 tabolites in serum samples from a unique and deeply phenotyped healthy human cohort of 491 individual

202 sing functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthrit

203 ted comorbid conditions; (2) repositories of deeply phenotyped physiological data and human tissue, m

204 nce of individuals with catatonic signs in a deeply phenotyped schizophrenia sample (n = 1095).

205 opean) had whole-genome sequencing, and were deeply phenotyped using metabolomics, advanced imaging,

206 ite the fact that most GWAS are conducted in deeply-phenotyped cohorts with many correlated traits me

207 the intravitreous injection and (2) in more deeply pigmented eyes.

208 Our approach deeply probes ligand space accessible via our synthetic

209 ment, demonstrating the utility of DIMEN for deeply probing biochemical networks that generate extens

210 We use strand-specific RNA-seq to deeply profile lncRNAs from polyadenylated and total RNA

211 Na-NaLi system could enable the creation of deeply quantum degenerate dipolar molecules and raises t

212 over, the as-produced GO can be subsequently deeply reduced (3.2 at.

213 This in turn, deeply reduces the solubility of the surface-bound prote

214 ta suggest that U(IV) can be mobilized under deeply reducing conditions, which may contribute to main

215 We deeply regret these errors and apologize to the scientif

216 Conservation laws are deeply related to any symmetry present in a physical sys

217 Here we describe two populations of the deeply rooted archaeal phylum Korarchaeota, which were r

218 ssimilatory sulfur reduction within a single deeply rooted archaeal population and have implications

219 This deeply rooted cultural tradition is unlikely to be aboli

220 The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression.

221 ta show that rudimentary multicellularity is deeply rooted in the Ascomycota.

222 Archaea are a distinct and deeply rooted lineage that harbor eukaryotic-like mechan

223 e explained this paradox by the existence of deeply rooted or intrinsic gender differences in prefere

224 This geographic disparity, in addition to deeply rooted structural inequities, have posed addition

225 owstone National Park to investigate whether deeply-rooted archaea possess and express novel mcrA gen

226 2019 (COVID-19) pandemic not only challenged deeply-rooted daily patterns but also put a spotlight on

227 logenomic analyses place SAGMEG Archaea as a deeply rooting sister clade of the Thermococci, leading

228 ansition is observed, and it becomes best to deeply sample a very small fraction of alternatives, whi

229 To address these questions, we combine a deeply sampled phylogeny for a major flowering plant cla

230 Highly resolved and deeply sampled trees are being leveraged in novel ways t

231 t few studies have tested this assumption by deeply sampling the distributions of mutational effects

232 torque, we derive design rules that lead to deeply scalable spin-orbit devices.

233 g experimentally verified models, we propose deeply scaled spin-orbit devices exhibiting high-speed d

234 m thousands of kilobase-scale deletions that deeply scan across a targeted region in a tiling fashion

235 oparticles may be good candidates for PDT in deeply seated tumors when combined with X-rays and conju

236 d into four levels denoted "comatose" (-5), "deeply sedated" (-4 to -3), "lightly sedated" (-2 to 0),

237 ll sedatives, volatile agents are capable of deeply sedating patients, which can have respiratory dep

238 tagenomic samples, it remains challenging to deeply sequence them.

239 atasets, to measure their prominence in less deeply sequenced data.

240 ed web server for processing and visualizing deeply sequenced data.

241 We used a deeply sequenced dataset of 910 individuals, all of Afri

242 estimated rate of genotyping errors even in deeply sequenced genomes and exomes.

243 Here we present genetic variation from deeply sequenced genomes of 642 individuals from North a

244 ethod, we assessed a study population of 475 deeply sequenced human genomes for genomic call rate, ge

245 d characterize structural variants in 17,795 deeply sequenced human genomes.

246 large-scale transcriptomic study of AD with deeply sequenced RNA-sequencing samples using long (126-

247 nsus sequences), and within human hosts (401 deeply sequenced SARS-CoV-2 samples).

248 genetically diverse maize inbred lines were deeply sequenced to identify genes exhibiting high and l

249 We apply GangSTR to a deeply sequenced trio to profile the landscape of TR exp

250 we assess the viral community ecology of 22 deeply sequenced viral metagenomes along a gradient of o

251 to well-characterized genomes that have been deeply sequenced with both short and long reads.

252 od samples from patients with acute EVD were deeply sequenced.

253 Antarctic Zone, which reduced the leakage of deeply sequestered carbon dioxide and thus contributed t

254 echanisms responsible for the release of the deeply sequestered carbon to the atmosphere at deglaciat

255 ied one ethyl methanesulfonate (EMS) mutant, deeply serrated (des), in the woodland strawberry Fragar

256 f the behavioral dichotomy, and for a novel (deeply shaded gorges) environment causing the shift to d

257 Sandstone gorges offered cane toads novel, deeply shaded habitat.

258 performance and survivorship of seedlings in deeply shaded tropical forests.

259 in Crystal Geyser (Utah, USA), a site where deeply sourced CO2 -saturated fluids are erupted at the

260 e we use helium and carbon isotope data from deeply sourced springs along two cross-arc transects to

261 le, dynamically formed cationic species with deeply stabilized intermediate structures that correspon

262 One important debate involves how deeply stone-tipped projectiles penetrate a target.

263 Even pockets as tightly defined and as deeply studied as that of the muscarinic reveal opportun

264 The likely more deeply studied P. aeruginosa virulence determinant is th

265 t galls are made for foes, some of which are deeply studied pathogens and pests: Agrobacterium tumefa

266 sequent Neanderthal population was large and deeply subdivided.

267 rage capabilities, but also demonstrate that deeply submerged, redox-active nanoparticles could be en

268 and characterize the spatial evolution of a deeply subwavelength canalization mode near the transiti

269 igate the implementation of this material in deeply subwavelength multimaterial nanowires, which can

270 Such deeply subwavelength resonators are of interest for high

271 n wave transformation, associated with their deeply subwavelength thickness, challenge their implemen

272 r structure, from ambient temperature to the deeply supercooled and amorphous states, and of water di

273 a metastable liquid-liquid critical point at deeply supercooled conditions and that this critical poi

274 is that water has a second critical point at deeply supercooled conditions was formulated to provide

275 en elusive due to rapid ice nucleation under deeply supercooled conditions.

276 amorphous phases to two liquid waters in the deeply supercooled regime (below 228 kelvin) to explain

277 the light of evolution, and vice versa, more deeply than ever before.

278 nts, such as tire abrasion, infiltrated less deeply than spherical particles, probably due to the ent

279 NMT, in which the benzyl ring is bound more deeply than the isoquinoline rings.

280 ss than thaw, indicating that higher Reco in deeply thawed areas during summer months was balanced by

281 Nonsummer CO2 loss in warmer, more deeply thawed soils exceeded the increases in summer GPP

282 e major advancements in its ability to probe deeply through turbid media such as biological tissues.

283 an genomes have been sequenced, contributing deeply to biomedical research.

284 t mud-silt substrate, projecting their claws deeply to register their traces on an underlying sand la

285 terised by a tendency to process information deeply, to be easily overstimulated, and to have strong

286 These include 1) the need for wider and more deeply transdiagnostic samples collected while minimizin

287 inequity, to achieve a brighter future for a deeply troubled region of the world.

288 We show that the deeply uncertain WAIS contribution can dominate other un

289 sea-level projections that approximates the deeply uncertain WAIS contributions.

290 rtage of donor organs has made it crucial to deeply understand and better predict donor liver viabili

291 nanomedicines inspire the community to more deeply understand nano-bio interactions in not only tumo

292 ach used in the present study can be used to deeply understand the cognitive factors underlying surgi

293 We used three steps to deeply understand the drivers of such dramatic changes:

294 , better designing clinical trials, and more deeply understanding cardiac biology.

295 will find widespread usage together for more deeply understanding protein-ligand interactions.

296 12 patients additional deposits were placed deeply using ultrasound guidance (total of 6; 0.07 mL ea

297 s of quarks and gluons inside nucleons using deeply virtual Compton scattering (DVCS)-a highly virtua

298 ometry shows that it penetrates the membrane deeply, whereas gamma-aminobutyric is excluded from the

299 new way to connect psychological theory more deeply with artificial intelligence, economics, neurosci

300 In vivo imaging, which enables us to peer deeply within living subjects, is producing tremendous o