ライフサイエンスコーパス: defeat

1 and female California mice exposed to social defeat.

2 ns mimicked the behavioral effects of social defeat.

3 reased social approach in male mice naive to defeat.

4 from extremes of great victory to injury and defeat.

5 les did not experience either a victory or a defeat.

6 interaction behavior in female mice naive to defeat.

7 inent in a subpopulation of rats that resist defeat.

8 r a purely emotional stressor termed witness defeat.

9 cur in mice with forebrain GR deletion after defeat.

10 ect was observed on other symptoms of social defeat.

11 ility in the forced swim test, as did social defeat.

12 ction and depression models including social defeat.

13 licit avoidance after, but not before social defeat.

14 rom the cell once a viral infection has been defeated.

15 ling molecules in response to chronic social defeat, 2) brain reward function during social defeat an

16 reshold stress (i.e., single cycle of social defeat) 24 days after RSD, and immune and behavioral mea

17 ecently, AlphaGo became the first program to defeat a world champion in the game of Go.

18 s the first time that a computer program has defeated a human professional player in the full-sized g

19 ting multiple challenging hurdles, including defeating a sizable ligand with subnanomolar affinity fo

20 g steepness (the probability that a dominant defeats a subordinate based on their difference in rank)

21 The UNAIDS-Lancet Commission on Defeating AIDS-Advancing Global Health reported that the

22 0 against the previously published, champion-defeating AlphaGo.

23 Here we show that social defeat, although not producing depression by itself, pro

24 used the allergenic food, causing a sense of defeat among caregivers.

25 nd 3) forced swim test behavior after social defeat and fluoxetine treatment.

26 was assessed in adult male rats using social defeat and intracranial self-stimulation, while changes

27 feat, 2) brain reward function during social defeat and long-term treatment with the antidepressants

28 pecies-typical behaviors were collected from defeated and control females.

29 s of mPFC gene expression changes induced by defeat, and biological pathway analysis revealed a domin

30 ckout mice were subjected to repeated social defeat, and immune and behavioral parameters were determ

31 In socially defeated animals, we found significant reductions in the

32 s, including G-protein-coupled receptors, in defeated animals.

33 Compared with controls, defeated B6 females exhibited elevated plasma corticoste

34 ution to study social affiliation and social defeat behaviors.

35 hlights the fact that previous victories and defeats both enhance aggressive behaviour in olive fruit

36 ure wherein one mouse witnesses the physical defeat bout of a conspecific from the safety of an adjac

37 ld, null parity) vicariously experienced the defeat bout of a male conspecific, by a male CD1 aggress

38 sed in the posterior VTA (pVTA) during acute defeat, but, with repeated defeat, CRF is recruited into

39 stress, male C57BL/6 mice experienced daily defeat by a CD-1 aggressor, for 10 days.

40 hallenged with a competitor that they cannot defeat by counter prediction.

41 e desired halide substitution event is often defeated by destruction of the sulfur electrophile becau

42 t specificity, with most R genes having been defeated by former pests, or do plants harbor a rich div

43 Incompatibility is defeated by transfer of pthXo1 to otherwise xa5-incompat

44 For 10 days, aggressive CFW female residents defeated C57BL/6J (B6) female intruders during 5-minute

45 ivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against m

46 Social defeat caused a weakening of functional connectivity bet

47 We observed that social defeat caused anxiety-like behaviors in mice and dampene

48 ter social defeat they exhibit a conditioned defeat (CD) response characterized by increased submissi

49 animal could move freely between a home and defeat chamber, firing activity emerged that predicted t

50 luence their environment, prevent predation, defeat competitors, or communicate.

51 The states act sequentially to defeat consecutive host barriers of the peripheral nervo

52 VTA) during acute defeat, but, with repeated defeat, CRF is recruited into the anterior VTA (aVTA) an

53 Chronic social defeat (CSD) in male mice can produce anxiety and aberra

54 The chronic social defeat (CSD) paradigm in mice produces mood alterations

55 with MDD and rats exposed to chronic social defeat (CSD) stress, which is used to model depression.

56 After chronic social defeat, D2-MSNs exhibit increased spine density that is

57 behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent social avoi

58 The mice receiving lymphocytes from defeated donors showed less anxiety, more social behavio

59 Pancreatic cancer (PC) is difficult to defeat due to mechanism (s) driving metastasis and drug

60 p, and active coping behaviors during social defeat episodes were associated with subsequent reinstat

61 re glucocorticoid receptor activation during defeat episodes.

62 hat achieve social dominance prior to social defeat exhibit greater defeat-induced neural activity in

63 igions, which began amongst pastoralists and defeated exiles, are closer to Big Gods than those assoc

64 h typically are excluded from classic social defeat experiments.

65 eeking in stressed animals long after social defeat exposure.

66 ens use host fatty acids to bypass FASII and defeat FASII therapeutics.

67 actions increased 24 hours after chronically defeated female mice received a systemic dose of ketamin

68 Chronically defeated females also showed vigilance-like behavior and

69 , an AI that, in a 120,000-hand competition, defeated four top human specialist professionals in head

70 etter prepared to rapidly detect, define and defeat future pandemics.

71 al judgment, and therefore, May's attempt to defeat general skepticism fails.

72 Viruses can evolve quickly to defeat host immune functions.

73 According to the social defeat hypothesis, the long-term experience of exclusion

74 ffects on plant hormone pathways not only to defeat immunity, but also modify habitat structure, opti

75 in the RI test and experiences of victory or defeat in contest 1.

76 Protection from social defeat in G-allele carriers was associated with a greate

77 investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of

78 Subthreshold social defeat in RSD-sensitized mice increased peripheral macro

79 ocial stressor that involves repeated social defeat in subordinate mice.

80 avioral consequences accompany victories and defeats in dyadic pairings between male Drosophila melan

81 Acute exposure to a third episode of defeat increased OT/c-fos colocalizations in the paraven

82 ventral bed nucleus of the stria terminalis, defeat increased Oxt messenger RNA, total OT neurons, an

83 Moreover, subthreshold social defeat increased social avoidance in RSD-sensitized mice

84 Finally, we found that social defeat induced a functional reorganization of neural act

85 Repeated defeats induced a long-lasting loser effect that was dep

86 nvestigate the genetic mechanisms subserving defeat-induced behavioural change.

87 Defeat-induced changes in immobility in floxed GR mice w

88 neuronal activity is associated with social defeat-induced depression- and anxiety-like behaviors in

89 Defeat-induced gene expression of the neuronal activity

90 Repeated social defeat-induced macrophage recruitment to the brain corre

91 nance prior to social defeat exhibit greater defeat-induced neural activity in infralimbic (IL) corte

92 Social defeat induces long-lasting increases in OT production a

93 he combined data suggest that chronic social defeat induces molecular changes that reduce myelination

94 umor suppressors may provide a potent way to defeat intratumor heterogeneity.

95 e have previously shown that rats with short-defeat latencies (SL/vulnerable rats) show increased anx

96 ocially defeated rats show long-latencies to defeat (LL/resilient) and are similar to controls.

97 the Carthaginians in the face of successive defeats, loss of mining territory, and the imposition of

98 laria Partnership's Action and Investment to defeat Malaria 2016-2030, and From Aspiration to Action:

99 The history leading to that defeat may be relevant to these future issues.

100 To support the goals of "Defeating Meningitis by 2030," MenAfriNet will continue

101 While 64% of defeated mice on curcumin were resilient (responders), t

102 A robust female social defeat model is a critical first step in the identificat

103 spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory t

104 examine OT neuron activity immediately after defeat (n = 6-9) and 2 weeks (n = 6-9) and 10 weeks (n =

105 racterized the longitudinal effect of social defeat on goal-directed actions and prefrontal cortical

106 ned acute and long-lasting effects of social defeat on OT neurons in male and female California mice.

107 fic datasets of varied types and effectively defeat one cancer patient at a time.

108 to propose a policy matrix that can help to defeat online hate, classified by the preferred (or lega

109 ocial stressors (PD35-44), namely the social defeat or vicarious defeat stress paradigms-procedures t

110 Previous defeats or victories during aggressive interactions have

111 successful, by definition, because they can defeat our immune response.

112 We report a new version of the social defeat paradigm that works in female mice.

113 Adoption of this modified social defeat paradigm will help advance the initiative to incl

114 antidepressant effects in the chronic social defeat paradigm, whereas inhibition of CaMKII activity i

115 -275, in the tail suspension test and social defeat paradigm.

116 6 mice by subjecting them to a 10-day social defeat paradigm.

117 ion, reveals clear differences in the social defeat phenotype induced by Fosb gene manipulation in MS

118 ency (SL) or longer latency (LL) to assume a defeat posture, respectively.

119 TA and CRF-R2 in the aVTA during each social defeat prevented escalated cocaine self-administration i

120 threat as well as by a chamber where social defeat previously occurred.

121 Repeated defeat produced alterations in forced swim and tail susp

122 We tested whether chronic social defeat produces structural alterations in the mPFC in mi

123 Social defeat profoundly and persistently decreased brain rewar

124 ic, but not a short and subthreshold, social defeat protocol was necessary to increase CA1 engram cel

125 Searching for new strategies to defeat Pseudomonas aeruginosa is of paramount importance

126 h partial resistance, they are the result of defeated qualitative resistance due to avirulent races,

127 Notably, defeated rats display enhanced learning of contextual cu

128 The other half of socially defeated rats show long-latencies to defeat (LL/resilien

129 We found that CNO treatment during social defeat reduced the acquisition of CD in subordinate, but

130 In the ventral tegmental area, social defeat, regardless of susceptibility or resilience, decr

131 approaches to activate and inactivate social defeat-related CA1 engram cells enhanced and suppressed

132 cial defeat stress model, we examined social defeat-related hippocampal engrams in mice that are eith

133 TetTag mice were used to label social defeat-related hippocampal ensembles by LacZ.

134 ce exhibited a higher reactivation of social defeat-related LacZ-labeled cells (i.e., engram cells) i

135 Despite social defeats, resilient mice with normal sociability showed n

136 d control and defeated-susceptible mice, and defeated-resilient mice more resembled control mice.

137 ting mechanisms of cellular physiology while defeating restriction factors that are dedicated to halt

138 leaning capacity and effective dirt capture, defeating risks for the artifact, making possible a safe

139 In socially defeated rodents, a model for depression, GABABR and 14-

140 rust fungi exploit the PstGSRE1 effector to defeat ROS-associated plant defense by modulating the su

141 Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitization that

142 Our previous work using repeated social defeat (RSD) in mice showed that recruitment of peripher

143 Repeated social defeat (RSD) is a mouse model of psychosocial stress tha

144 Repeated social defeat (RSD) is a murine stressor that recapitulates key

145 Repeated social defeat (RSD) stress in mice increases the release of mon

146 In a model of repeated social defeat (RSD), elevated IL-1beta expression in the brain

147 ral patterns associated with repeated social defeat (RSD).

148 Using a chronic social defeat (SD) stress model, learned helplessness (LH), and

149 sceptible and resilient mice after the first defeat session and continue to diverge following success

150 Mice received lactate before each defeat session.

151 al analysis confirmed that the 14-day social defeat sessions resulted in induction of depressive-like

152 lly avoidant by the stress of chronic social defeats showed depressed neural activity in the left mPF

153 Despite Myriad's defeat, some questions concerning the rights to monopoli

154 ze a novel chronic non-discriminatory social defeat stress (CNSDS) paradigm that results in comparabl

155 c of male mice that underwent chronic social defeat stress (CSDS) and in patients with major depressi

156 at adult mice which underwent chronic social defeat stress (CSDS) displayed elevated anxiety-like beh

157 Exposure of Ghsr-null mice to chronic social defeat stress (CSDS) elicits more severe depressive-like

158 in at promoting resilience to chronic social defeat stress (CSDS) in 129/SvEv mice, a strain that we

159 We performed chronic social defeat stress (CSDS) in mice and evaluated behavior with

160 Animal studies using chronic social defeat stress (CSDS) in mice showed that brain-derived n

161 Chronic social defeat stress (CSDS) is a well-established rodent model

162 in combination with a 10-day chronic social defeat stress (CSDS) model in male mice to investigate w

163 activity of vmPFC DBS in the chronic social defeat stress (CSDS) model of depression (n = 8-13 mice/

164 iors in adult mice, using the chronic social defeat stress (CSDS) model of depression.

165 in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behaviora

166 re we examined the effects of chronic social defeat stress (CSDS), an ethological form of stress, on

167 ects and in mice subjected to chronic social defeat stress (CSDS).

168 ransgenic mice that underwent chronic social defeat stress (CSDS).

169 Ac regulate susceptibility to chronic social defeat stress (CSDS).

170 ehaviors in mice subjected to chronic social defeat stress (CSDS).

171 roinjected into the VTA 20 min before social defeat stress (or handling) on days 1, 4, 7, and 10.

172 Repeated social defeat stress (R-SDS) reduces the expression of D1 recep

173 osure to either subthreshold repeated social defeat stress (RSDS) or a purely emotional stressor term

174 merous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechan

175 and behavioral responses to repeated social defeat stress (RSDS), a mouse model of stress vulnerabil

176 Single social defeat stress (S-SDS) induces D1 receptor-mediated extra

177 icted susceptibility or resilience to social defeat stress (SDS) in mice and 2) administration of ace

178 Using social defeat stress (SDS) in mice, here we identified a role o

179 leads to increased susceptibility to social defeat stress (SDS), a model of psychosocial stress, and

180 nced susceptibility to a subthreshold social defeat stress (SSDS) as observed by reduced social inter

181 Here, we employed chronic mild social defeat stress and 16S rRNA gene metagenomic sequencing t

182 tially expressed genes, while chronic social defeat stress and adult social isolation better reproduc

183 nit knockdown decreased resilience to social defeat stress and c-fos immunoreactivity in the BLA.

184 iod increases susceptibility to adult social defeat stress and causes long-lasting transcriptional al

185 ind that female mice undergo repeated social defeat stress and develop social avoidance, decreased su

186 x (mPFC) is activated by subthreshold social defeat stress and suppresses the induction of depressive

187 ed mice to chronic cocaine or chronic social defeat stress and used two-photon laser scanning microsc

188 C57BL/6 mice underwent 10 days of social defeat stress and were subsequently tested for social av

189 t depression-like behavior induced by social defeat stress arises from disrupted DOR signaling result

190 e susceptible or resilient to chronic social defeat stress at multiple time points.

191 ranscriptional phenomena that control social defeat stress behavior.

192 Social defeat stress causes dendritic morphological changes on

193 We show here that repeated social defeat stress causes increased pain sensitivity due to i

194 Here we show that chronic social defeat stress decreases messenger RNA and protein levels

195 Intermittent social defeat stress escalates later cocaine self-administratio

196 cence associate with vulnerability to social defeat stress in adulthood, with high levels associated

197 s after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial c

198 lows researchers to perform vicarious social defeat stress in males or females and in juvenile mice,

199 Here we show that repeated social defeat stress in mice activated threat appraisal centers

200 We have reported that repeated social defeat stress in mice caused recruitment of proinflammat

201 Chronic social defeat stress in mice produces a susceptible phenotype c

202 We show that chronic social defeat stress in mice produces progressive alterations i

203 Here, we show that repeated social defeat stress in rats causes persistent enhancement of l

204 Intermittent social defeat stress induces both locomotor and dopaminergic cr

205 nces exist in stress responsivity and social defeat stress is a key approach for identifying cellular

206 The susceptibility to chronic social defeat stress is regulated by hippocampal CA1 engrams fo

207 The chronic social defeat stress model has been instrumental in shaping our

208 In a social defeat stress model of depression, depressed (susceptibl

209 In the chronic social defeat stress model of depression, we report that KCNQ-t

210 Using the chronic social defeat stress model, we examined social defeat-related h

211 17, and 20, animals were subjected to social defeat stress or a nonstressful control condition follow

212 aFosB is induced in NAc after chronic social defeat stress or after chronic antidepressant treatment,

213 phocytes from mice undergoing chronic social defeat stress or from unstressed control mice were isola

214 enkephalin function we used a chronic social defeat stress paradigm, where animals are either categor

215 5-44), namely the social defeat or vicarious defeat stress paradigms-procedures that mediated a depre

216 However, the classic chronic social defeat stress procedure is limited by its exclusive appl

217 recently developed a novel vicarious social defeat stress procedure wherein one mouse witnesses the

218 Chronic social defeat stress regulates the expression of Fosb in the nu

219 Repeated social defeat stress resulted in repeated episodes of dramatic

220 inase inhibitor Y-27632 after chronic social defeat stress reverses depression-like behaviors by rest

221 epressive-like symptoms after chronic social defeat stress show distinct changes in the activity of t

222 These findings indicate that social defeat stress specifically activates neurons in distinct

223 Here we show that social defeat stress specifically increased c-Fos expression, a

224 Mice subjected to chronic social defeat stress were stratified into resilient and vulnera

225 male mice that have undergone chronic social defeat stress, a mouse model of depression, at both the

226 We investigated the effect of chronic social defeat stress, a mouse model of depression, on blood-bra

227 etamine, in mice subjected to chronic social defeat stress, a validated depression model, and used RN

228 We found that chronic social defeat stress, an animal model recapitulating some aspec

229 relapse to cocaine use in rats using social defeat stress, an ethologically valid psychosocial stres

230 e present study, we show that chronic social defeat stress, an ethologically validated model of depre

231 We applied chronic social defeat stress, an ethologically validated mouse model of

232 of postmortem brain tissue, mouse models of defeat stress, and in vitro analysis, we assessed microR

233 H), novelty-suppressed feeding (NSF), social defeat stress, and learned helplessness.

234 ely in susceptible mice after chronic social defeat stress, and overexpression of DeltaFosB in this r

235 CY-738 promoted resilience to chronic social defeat stress, and serotonin-selective viral overexpress

236 In a murine model of acute social defeat stress, Asb1 gene expression was significantly up

237 reactivity to aversive stimuli (i.e., social defeat stress, forced swimming, and elevated plus maze)

238 Mice resilient to social defeat stress, however, exhibit stable normal firing of

239 the mouse that physically experiences social defeat stress, modeling multiple aspects of major depres

240 After chronic social defeat stress, NAc MSNs exhibit increased dendritic spin

241 After chronic social defeat stress, resilient animals displayed an upregulati

242 reased susceptibility to subthreshold social defeat stress, suggesting that neuronal VGF, expressed i

243 Using a model of chronic social defeat stress, we identified region-specific differences

244 siological adaptations in response to social defeat stress, which are normalized by antidepressant tr

245 as one commonly used paradigm-chronic social defeat stress-has proven challenging to implement in fem

246 )-induced escape deficits and chronic social defeat stress-induced anhedonia.

247 s, D1 knockdown in the mPFC decreased social defeat stress-induced c-Fos expression in the interstiti

248 ession-related behavior after chronic social defeat stress.

249 nts in an ethological model of female social defeat stress.

250 NAc and enhanced susceptibility to a social defeat stress.

251 ontaining MSNs of mice susceptible to social defeat stress.

252 translated in a mouse model of acute social defeat stress.

253 ne in NAc regulates susceptibility to social defeat stress.

254 e NAc of resilient mice after chronic social defeat stress.

255 events social avoidance after chronic social defeat stress.

256 cocaine withdrawal and after chronic social defeat stress.

257 nistration, and resilience to chronic social defeat stress.

258 n vivo recordings in mice and chronic social defeat stress.

259 nd mice that are resilient to chronic social defeat stress.

260 leus of vulnerable mice after chronic social defeat stress.

261 cial avoidance following subthreshold social defeat stress.

262 tor of depression-related outcomes to social defeat stress.

263 ses after mice are exposed to chronic social defeat stress.

264 depression-like phenotype induced by chronic defeat stress.

265 oral abnormalities seen after chronic social defeat stress.

266 tress using a murine model of chronic social defeat stress.

267 , adult social isolation, and chronic social defeat stress.

268 h social avoidance in mice subject to social defeat stress.

269 n mediating vulnerability to repeated social defeat stress.

270 rats regulates resilience to chronic social defeat stress.

271 on of ERK, which was downregulated by social defeat stress.

272 hibit RhoA activity following chronic social defeat stress.

273 excitatory input to D1-MSNs caused by social defeat stress.

274 II histone deacetylase, after chronic social defeat suggest a role for this enzyme in mediating depre

275 fter CSDS successfully separated control and defeated-susceptible mice, and defeated-resilient mice m

276 h imipramine induced a 40.2% recovery of the defeated-susceptible phenotype as assessed by SmartCube.

277 rticipants [43%]); (2) successful efforts to defeat the ADF mechanism leading to a continuation of in

278 is one of the most ideal energy resources to defeat the environmental degradation caused by the consu

279 y an opt-out default, while 'good shepherds' defeat the free-riding encouraged by an opt-in default.

280 ecome prohibitively cumbersome and which can defeat the purpose of linking model elements to controll

281 The emergence of drug resistance can defeat the successful treatment of pathogens that displa

282 advanced artificial intelligence (AI) system defeated the best human players in StarCraft II, a popul

283 winning rate against other Go programs, and defeated the human European Go champion by 5 games to 0.

284 rent devices for accelerating the process of defeating the pandemic is proposed.

285 ) that the external force on condensate bulk defeats the adhesive force between the condensate and th

286 ble territorial aggression, but after social defeat they exhibit a conditioned defeat (CD) response c

287 ue, alternative strategies will be needed to defeat this devastating disease.

288 It is possible to defeat this mechanism and activate T cells with solution

289 e to inspire immunologists to participate in defeating this devastating disease.

290 ajor factor in promoting inactivation, which defeats transmission, and is allosterically coupled to p

291 ht how a zone of high rock uplift could have defeated transverse drainage networks, resulting in subs

292 eported experiencing more feelings of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=87.5, z

293 g that adaptive immunity has the capacity to defeat viral escape.

294 rk as organized and heterogeneous systems to defeat virus infection, and how the virus counteracts th

295 Using a rodent model of social defeat, we have previously shown that rats with short-de

296 how the strength-ductility trade-off can be defeated, we apply in situ, and aberration-corrected sca

297 related differences in behavioral effects of defeat, whereas c-fos induction in the nucleus accumbens

298 susceptibility to a single session of social defeat, whereas overexpression of miR-218 selectively in

299 to-BLA neural projection during acute social defeat will reduce the CD response in subordinate hamste

300 ist directly into the VTA before each social defeat would prevent the development of later (1) locomo