ライフサイエンスコーパス: defective

1 heir survival there have been reported to be defective.

2 cells to grow so large that cell division is defective.

3 ome translocation to the host's cytoplasm is defective.

4 d localization of cohesin and condensin were defective.

5 ts, or hypermutations that would render them defective.

6 cripts requires the host factor nuclear RNAi-defective 2 (NRDE2), which has previously been reported

7 ity of OGG1 and RECQL4 deficiency results in defective 8-oxoG repair and increased genomic 8-oxoG.

8 pt intermediary metabolic pathways and cause defective absorption and metabolism of dietary nutrients

9 rom adoptive transfer studies suggested that defective accumulation of CRTH2-deficient ILC2s in respo

10 dge coordination during path finding and (2) defective adhesion resolution.

11 BCAP deficiency also results in defective aerobic glycolysis and reduced lactate product

12 riptional program, increased cell death, and defective AID expression.

13 etically compromised CNS cells, we find that defective AIM2 inflammasome signalling results in decrea

14 were exploited to investigate the impact of defective allosteric regulation on one-carbon metabolism

15 amino acid-induced mTORC1 signaling, causing defective amino acid anabolism, reduced T reg cell proli

16 However, the correlation between these defective angles and the severity of visual field defect

17 rafish intestine and identified mutants with defective apical targeting of membrane proteins.

18 Cells from both patients showed defective Arl13b localization to the primary cilium.

19 A linked BchL dimer with one defective ATP-binding site does not support protochlorop

20 which reduces cytosolic calcium, rescues the defective ATP2C1 KO phenotype and AAV transduction in vi

21 AC), thus undergoing mitotic slippage due to defective AURKB and impaired SAC activity, downstream of

22 ministration of FGF21 in obese mice improves defective autophagy and hepatosteatosis in a JMJD3-depen

23 Our results implicate defective autophagy in SHRF pathogenesis and suggest the

24 nd molecular signatures including ER stress, defective autophagy, mitochondrial dysfunction, apoptosi

25 se-alpha expression in G6pc-/- mice corrects defective autophagy, restores SIRT1/FoxO3a/AMPK/PPAR-alp

26 Hepatic SIRT1 overexpression corrects defective autophagy, restores the expression of FoxO3a a

27 entral disk organization, loss of the funis, defective axoneme exit, and altered cell shape.

28 n in case of intrinsic B-cell defect, but in defective B-cell repopulation in a nonpermissive environ

29 ently, BSEP and SHP expression, resulting in defective BA metabolism and hepatotoxicity with inflamma

30 717 genomes from wild-type and 53 DNA repair defective backgrounds, exposed to 11 genotoxins, includi

31 0% of phagocytes and sufficient to result in defective bacterial handling but not life-threatening in

32 can modulate miRNA expression and repair the defective barrier in AD.

33 These data identify defective Bcl-6(+) T(FH) cell generation and dysregulate

34 Genome editing to correct a defective beta-globin gene or induce fetal globin (HbF)

35 in C6(-/-) mice, the NLRP3 inflammasome was defective both in PMNs and in macrophages.

36 Defective Ca(2+) signaling in the diabetic beta-cell alt

37 a prime target for homologous recombination-defective cancers.

38 Defective canonical NF-kappaB activation in the absence

39 which there is an appreciable population of defective capsids.

40 RNA knockdown (Taz(KD) ) mice, which exhibit defective cardiolipin remodeling and respiratory superco

41 ost in cells expressing CDK1 phosphorylation-defective CDC20(6A) mutants.

42 nts that displayed loss of ERK signaling and defective cell differentiation, Etv deficiency augmented

43 ll division and if not maintained results in defective cell function caused by the abnormal distribut

44 ed with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the m

45 lls, this apoptotic response occurred in p53-defective cells and cell killing was not blocked by a pa

46 e cells, we used OXPHOS-competent and OXPHOS-defective cells.

47 roper metaphase alignment is an indicator of defective chromosome congression and aberrant kinetochor

48 Importantly, this defective CI-dependent decrease in mitochondrial NADPH p

49 These associations may be explained by defective clearance of intraorgan microthrombi that have

50 Loss of BLT1 signaling led to defective clearance of neutrophils from the inflamed joi

51 agy and the ubiquitin-proteasome system, and defective clearance of these protein aggregates results

52 lude reduced axonal transport, synapse loss, defective climbing ability and olfactory perception, as

53 h throughput analytical screening to discard defective cocoa samples.

54 within complex III subassemblies, leading to defective complex IV assembly as well.

55 ely, hyperdiploid B-ALL is associated with a defective condensin complex, AURKB, and SAC.

56 Defective cystine transport leads to intralysosomal accu

57 ne marrow-derived macrophages (BMMs) exhibit defective cytosolic killing of L. monocytogenes We furth

58 atic beta-cell number (due to destruction or defective development) or impaired beta-cell function.

59 root and stem growth, slow flower formation, defective directionality of root growth, and aberrant fl

60 Inhibition of CDK6 but not CDK4 resulted in defective DNA repair and increased DNA damage.

61 ons to interactions with the microbiota, and defective DNA repair.

62 enous or endogenous exposures, as well as to defective DNA-maintenance processes.

63 tochondria caused by a mitochondrial fission-defective dynamin mutation is strongly suppressed to a m

64 easing Rab5a-facilitated endocytosis rescues defective early differentiation.

65 While HFrEF is characterized by defective EC coupling at baseline, HFpEF exhibits enhanc

66 had recovered from Arm infection have highly defective ECTV-specific CD8(+) and CD4(+) T-cell respons

67 to the medium of cultured human cells with a defective electron transport chain decreased the extrace

68 ract to regulate neuronal homeostasis during defective elongation.

69 I present an updated dataset of 510 EMBRYO-DEFECTIVE (EMB) genes identified throughout the Arabidop

70 details on 2200 emb mutants and 241 pigment-defective embryo (pde) mutants analyzed in my laboratory

71 e/+) Foxa2 (f/f) ) mice are infertile due to defective embryo implantation arising from a lack of LIF

72 Lange syndrome (CdLS), thought to arise from defective embryonic transcription.

73 l and dental defects, reduced body size, and defective endochondral bone growth due to impaired BMP-m

74 e fail to properly differentiate, leading to defective endochondral ossification.

75 mbrane is reduced in mutant mice, leading to defective endothelial cell-pericyte interactions.

76 cal and basolateral domains and suggest that defective ESCRT function may contribute to disease state

77 sent accumulated membrane proteins following defective exocytosis or recycling.

78 were depleted of PIP3, which resulted in the defective expression of over 60 lipid-raft-associated su

79 eficiency, with cytoskeletal dysfunction and defective extravasation of neutrophils as the most promi

80 grins back to the cell surface, resulting in defective FA reformation.

81 ouse cells show increased cancer risk due to defective ferroptosis.

82 affects reproductive development, including defective floral phyllotaxy and increased floral organ m

83 s the I1061T variant of NPC1, which exhibits defective folding and trafficking from the endoplasmic r

84 lation of Igf1r in primary follicles elicits defective follicle-stimulating hormone responsiveness bl

85 In strains defective for autophagy, beta5-GFP tagged proteasomes, u

86 e by identifying mutants in a genetic screen defective for butyrate-modulated transcription.

87 lophilin A and Nup358 recruitment) and N74D (defective for CPSF6 recruitment) have reduced dependency

88 binding defective HIV-1 capsid mutants P90A (defective for cyclophilin A and Nup358 recruitment) and

89 Cdc42p, Cdc42p(E100A), that is specifically defective for fMAPK pathway signaling, was defective for

90 , and interaction with the GEF, Cdc24p, were defective for fMAPK pathway signaling.

91 y defective for fMAPK pathway signaling, was defective for interaction with Bem4p, the pathway-specif

92 Versions of Bem1p defective for recruitment of Ste20p to the plasma membra

93 ppresses the embryonic lethality of a mutant defective for the apoptotic suppressor ced-9/Bcl-2 impli

94 tants in the xusABC locus (BT2063-2065) were defective for xenosiderophore-mediated iron uptake in vi

95 iment shows that knockdown of Shroom3 caused defective formation of lamellipodia in podocyte, which w

96 PTHrP-PPR signaling in these cells leads to defective formation of the periodontal attachment appara

97 Defective forms accumulated relative to intact ones anal

98 expression of known dominant-negative ATPase-defective forms of VPS4A.

99 Coloboma originates from defective fusion of the optic fissure (OF), a transient

100 yers), uniform, and continuous films of both defective gallium(II) sulfide (GaS): GaS(0.87) and stoic

101 evice performance, and both layer-controlled defective GaS(0.87) and stoichiometric GaS prove to be p

102 Although defective gene regulation often affects oncogenic and tu

103 vation of cell death to eliminate cells with defective genome.

104 a is an inborn error of metabolism caused by defective glucose-6-phosphatase catalytic subunit (G6PC)

105 ibition of DHTKD1, an enzyme upstream of the defective glutaryl-CoA dehydrogenase, has been investiga

106 nt can assist in the processing of otherwise defective hairpins.

107 nant of MxB sensitivity and cofactor binding defective HIV-1 capsid mutants P90A (defective for cyclo

108 -mediated tetherin degradation, resulting in defective HIV-1 release.

109 roups, with a subgroup harboring evidence of defective homologous recombination (HR) DNA repair.

110 replication forks, phenotype reminiscent of defective homologous recombination (HR).

111 response; mutational signature 3 reflecting defective homologous recombination DNA repair, and posit

112 hat maternal immunization with a replication-defective HSV vaccine candidate, dl5-29, leads to transf

113 o genetic instability in DNA mismatch repair-defective human tumors.

114 and genetic deletion of Cox4i2 mimicked the defective hypoxic responses of Epas1-null mice.

115 smic domain constructs in WT versus paranode defective (i.e., Caspr-null) mice.

116 albicans infection, mice lacking TAGAP mount defective immune responses, impaired Th17 cell different

117 Given the underlying defective immune surveillance of EBV, patients with high

118 us, critical for autophagosome formation, is defective in a human disease, and influences the way we

119 DRT111 knock-out mutants are defective in ABA-induced stomatal closure and are hypers

120 mutant are biotin auxotrophs, as are strains defective in CaiB which catalyzes glutaryl-CoA synthesis

121 conditional budding yeast mutants that were defective in cell division was reported.

122 Cep57 mutant cells defective in Cep63 binding exhibited improper Cep63 and

123 Mutants lacking a channel protein or defective in channel protein turnover exhibited modest a

124 The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophils and monocytes bot

125 picolinate herbicides, while pic30-3 is also defective in chlorate (analogue of nitrate) transport an

126 The psrp mutant is globally defective in chloroplast translation, and has varying de

127 suffer from hyperactive innate responses are defective in controlling a herpesvirus.

128 ptake; rather mac1Delta/Delta mutants appear defective in Cu allocation.

129 lled cells exhibited prolonged S-phase, were defective in DNA synthesis and had increased DNA damage

130 bly expressing WT SAMHD1 or mutated variants defective in dNTPase activity (HD/RN) or nuclear localiz

131 romyces cerevisiae mutants that are globally defective in forming crossovers and synaptonemal complex

132 his study, we created a P. aeruginosa mutant defective in GSH biosynthesis to examine how loss of GSH

133 alyzed cpk quadruple/quintuple mutants, were defective in high CO(2) -induced stomatal closure and, u

134 ng DnaA mutants revealed that DnaA(H136Q) is defective in initiating replication in vivo.

135 Yeast defective in internal-cue utilization align significantl

136 All 3 mutations were hERG trafficking defective in iPSC-CMs.

137 Mice defective in IRG1 rescued the virulence defect of a S. e

138 rica serovar Typhimurium mutant specifically defective in its ability to counter the Rab32 defense me

139 while mutants disrupting F-actin binding are defective in its tumorigenic capabilities.

140 th-defense phenotypes in a jaz mutant (jazQ) defective in JAZ1, JAZ3, JAZ4, JAZ9, and JAZ10, phyB nul

141 or that is functional in wild aneuploids but defective in laboratory strain W303.

142 able substrate-binding ability despite being defective in Lipid II transport.

143 Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and re

144 s reveal how monoubiquitinated FANCI:FANCD2, defective in many cancer types and all cases of FA, is a

145 ed in AC9 or AC10 replicate normally but are defective in microneme secretion and fail to invade and

146 nd an A. tumefaciens vtlR deletion strain is defective in motility, biofilm formation, and tumorigene

147 odel plant Arabidopsis thaliana and a mutant defective in mRNA methylation (m(6)A).

148 ic CB(2) knockouts and was increased in mice defective in neuronal CB(2) knockouts suggestive of incr

149 e we show that autophagy-deficient cells are defective in NHEJ, as indicated by decreased IR-induced

150 used steady-state RNA sequencing in mutants defective in nuclear RNA decay including the exosome to

151 ty against mouse and human cancer cell lines defective in O-linked glycosylation.

152 r cerk1; hereafter, mfec)(1), simultaneously defective in pattern-triggered immunity and the MIN7 ves

153 t retains high-affinity ATP binding, but was defective in producing replication-competent initiation

154 tutions at residues 18 and 20 of the NLS are defective in proper incorporation of nucleotides and RNA

155 Atg16L1 mutants that are defective in Rab33B binding still co-localize with WIPI2

156 at fibroblasts from individuals with LCC are defective in rRNA processing.

157 oth in wild-type yeast as well as in mutants defective in the biosynthesis of phosphatidylethanolamin

158 Here, we report that the imp1 mutant is defective in the BR-receptor BRASSINOSTEROID INSENSITIVE

159 vity were not properly regulated in a mutant defective in the transcription factor PSR1, which is the

160 Extracellular vesicle maturation was also defective in the vps27Delta mutant, which had a larger v

161 s lacking Grh1 are metabolically active, but defective in their ability to regrow upon return to grow

162 In vitro, BLT1(-/-) neutrophils were defective in their ability to undergo apoptosis due to t

163 showed decreased expression in mutant plants defective in these TCPs after an increase in ambient tem

164 An Arabidopsis mutant defective in two peroxisomal acyl-CoA oxidases does not

165 Furthermore, white blood cells showed defective in vitro killing of Staphylococcus aureus, con

166 Aging is associated with defective inflammation-resolution and the accumulation o

167 mates, genetically obese (ob/ob) mice have a defective inner colonic mucus layer that is characterize

168 recent biochemical studies that identified a defective interaction between mutant SF3B1 and SUGP1 as

169 In Mks from patients with CALR-mutated MPNs, defective interactions between mutant calreticulin, ERp5

170 s that retain replication competency, termed defective interfering (DI) genomes.

171 ated, infectious virus-like particles termed defective interfering particles (DIPs).

172 future models to describe co-infection with defective interfering particles, which are an emerging a

173 nt than the parental virus and generation of defective interfering RNA.

174 vRNAs) known as mini viral RNAs (mvRNAs) and defective interfering RNAs (DI RNAs) expressed from an I

175 IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron depo

176 ng-QT syndrome (LQT2) stems from trafficking defective KCNH2 mutations.

177 Defective Kernel 1 (DEK1) is genetically at the nexus of

178 GD1 and WPGD2 transgenes complement the pgd3-defective kernel phenotype, indicating the fusion protei

179 activation and IL-1beta production and that defective L. monocytogenes killing in P2X5-deficient BMM

180 Among the characteristics common to LasR-defective (LasR-) strains is increased activity of the t

181 med the gametophyte defect and also revealed defective leaf and root growth.

182 sed to DNA damage can become developmentally defective, leaving only those genetically fit cells to e

183 cell-to-cell spread by L. monocytogenes, 2) defective leukocyte recruitment to infection foci, and 3

184 Nematodes with this in-frame deletion show defective locomotion and muscle force generation.

185 Finally, defective LTbetaR signaling impaired compensatory glomer

186 that all are produced by transposition of a defective LTR retrotransposon that we have termed dRemp

187 g, increased adherens junctions, and rescued defective lumen formation induced by APT-1 deficiency.

188 in a high basal mTORC1 activity that drives defective lysosomes in cells and mice, leading to accumu

189 of nascent polypeptides that are encoded by defective messenger RNAs and undergo stalling at the rib

190 stasis, thereby alleviating telomere damage, defective mitochondrial biosynthesis and clearance, cell

191 activation, the patients' B cells exhibited defective mitochondrial respiration and impaired regulat

192 , the main metabolic product in KD, recovers defective mitochondrial respiration bypassing the metabo

193 cause neurodegenerative diseases, suggesting defective mitochondrial turnover contributes to neurodeg

194 ase depletion, enhanced membrane damage, and defective mitophagy.

195 It is interesting to note that the transport-defective MNESmut was recruited to IBperi.

196 d SPO11 cleavage complexes accumulate due to defective MRE11 initiation of resection.

197 distinguishes collision complexes formed on defective mRNAs from those with functional roles on endo

198 Additionally, the FA796-defective mutant had increased sensitivity to hydrogen p

199 rotransposons in the ADAR- and ERI-6/7/MOV10-defective mutant is associated with the induction of the

200 vo intestinal colonizing capacity of the Kpi-defective mutant was significantly reduced, as was its a

201 Here, we report the isolation of MltG-defective mutants as suppressors of lethal deficits in e

202 d are in fact increased in adar- and eri-6/7-defective mutants because of an antiviral RNAi response

203 ondrial fragmentation either in fzo-1 fusion-defective mutants or after acute drug treatment accelera

204 Stalled protein synthesis produces defective nascent chains that can harm cells.

205 and its inherent polycrystalline and highly defective nature.

206 tation assays demonstrated that dimerization-defective Nef mutants retained interaction with both SER

207 ion of SERINC5 was increased by dimerization-defective Nef mutants, whereas down-regulation of SERINC

208 Inappropriate stimulation or defective negative regulation of the type I interferon r

209 then determined crystal structures of ligase-defective NgrRnl-Ala mutants in complexes with ATP/Mn2+.

210 As expected for an assembly defective NiV, perinuclear inclusions (IBperi) were form

211 cytotoxic mechanisms, and patients who have defective NK cell development or function can present wi

212 that one aspect of diseases associated with defective Notch signaling, such as Alagille syndrome, ma

213 Using an M mutant with a defective nuclear export signal (MNESmut), however, we r

214 compromised antioxidant response guided by a defective Nuclear Factor Erythroid 2-Related Factor 2 pa

215 Defective nucleocytoplasmic transport contributes to C9-

216 s group of genetic conditions that result in defective or absent tooth enamel.

217 ns revealed weaker adsorption of methanol in defective or dehydrated nodes, in agreement with the lar

218 f antigen-responsive CD4+ T cells containing defective or intact latent proviruses were found in seve

219 that promotes remodeling of the partitioning-defective (PAR) polarity complex and leads to loss of ce

220 opy micrographs yields a confirmatory 15% of defective particles.

221 The genome of the meiosis-defective pathogen Candida albicans encodes an Rme1 homo

222 ic deletion of AMPKalpha or PGC1alpha causes defective PC maturation, which could not be rescued by m

223 This phenotype maps to defective PD-L1 upregulation on mutant tumor cells, whic

224 -6 PUFAs rescued the embryonic lethality and defective permeability barrier.

225 Moreover, the phenotype of UNC93B1-defective phagocytes could be recapitulated by the simul

226 ized a strain of E. coli that expresses a QC-defective PheRS.

227 Defective photosynthesis in ven4 seedlings results from

228 Gpr56 (-/-) mice have prolonged bleeding, defective platelet plug formation, and delayed thromboti

229 dgk2-1/+ dgk4-1/+ double heterozygote showed defective pollen tube growth and seed development becaus

230 Ubisch bodies, disrupted callose deposition, defective pollen wall formation such as abnormal microsp

231 racterized a novel rice male sterile mutant, defective pollen wall3 (dpw3), which displays smaller an

232 mutants show reduced levels of H3K27me3 and defective Polycomb repression of HOX genes.

233 al microspore plasma membrane undulation and defective primexine formation, resulting in pollen abort

234 Defective proinsulin processing has been implicated in t

235 ects or severe microcephaly, suggesting that defective proliferation and differentiation of neural pr

236 Defective proplatelet formation is considered to be the

237 n of intact proviruses but a distribution of defective provirus types and escaped or unrecognized epi

238 on, we have recently demonstrated that these defective proviruses are not silent, are capable of tran

239 We provide direct quantitative evidence that defective proviruses greatly outnumber intact proviruses

240 Likewise, the viral proteins coded in the defective proviruses may form extracellular virus-like p

241 The HIV-RNA transcripts expressed from these defective proviruses may trigger an element of innate im

242 anges in the proportions of various types of defective proviruses.

243 ng two delivery platforms, methyltransferase-defective recombinant vesicular stomatitis virus (mtdVSV

244 Delayed or defective recovery of the T cell pool has significant cl

245 expected high-concentration doping effect in defective regions is reported for correlated nickelates.

246 levels despite high-fat stores, indicating a defective response to cellular energy deficits.

247 AKI locus (EKI), which causes a mechanically defective response to weight stimulus resulting in stem

248 R retrotransposon that we have termed dRemp (defective retroelement mobile in pollen).

249 generated from non-canonical translation of defective ribosomal products, relate this to the dysregu

250 How stable proteins that rely on defective ribosomal proteins for direct presentation are

251 e to cis-regulatory ribosomal binding and to defective ribosomal scanning of ORFs outside periods of

252 These defective RNAs bind to retinoic acid-inducible gene I (R

253 Whether neurodegeneration results from defective RQC and whether defective RQC contributes to h

254 ation results from defective RQC and whether defective RQC contributes to human disease have remained

255 Defective RRM1 S559 phosphorylation causes DNA replicati

256 cating that phenytoin may selectively target defective RyR2 channels in humans and pointing to phenyt

257 cating that phenytoin may selectively target defective RyR2 channels in humans.

258 slow muscles, and loss of Smyhc1 results in defective sarcomere assembly, reduces larval motility an

259 KMT2D mutant NCCs lead to defective secondary palatal shelf elevation with reduced

260 e show that loss of TEAD4 is associated with defective self-renewal in RPL-TSCs and rescue of TEAD4 e

261 he CTNNBL1 M466V mutation is responsible for defective SHM induction.

262 tivity to topoisomerase and PARP inhibitors, defective sister chromatid cohesion and reduced DNA repl

263 ion to skin-draining lymph nodes (sdLNs) and defective skin tolerance induction, while talin1-deficie

264 nding between the incorporated hydrogen with defective SmNiO(3) is further analyzed by the positron a

265 at this human disorder is the consequence of defective snoRNP pseudouridylation and ribosomal dysfunc

266 f impaired IP3R function in combination with defective STIM1-mediated SOC channel activation, while C

267 Nodulation by succinoglycan-defective strains was achieved by in trans rescue with a

268 Defective structures are observed in computer simulation

269 In this work, modifying the defective surface of perovskite films with cadmium iodid

270 otor network activity, likely resulting from defective survival of a subset of limb-innervating motor

271 seful single-cell system to study aspects of defective synaptic plasticity in Coffin-Lowry Syndrome (

272 duces loss of PFC DA homeostasis, leading to defective synaptic transmission and plasticity as well a

273 tocrine feedback mechanism, which results in defective T cell migration, impaired T cell function, an

274 ar dynamic (MD) simulations suggest that the defective T-graphite provide numerous nucleation sites f

275 Mice with defective talin autoinhibition exhibit delays in melanob

276 tion in vivo Specifically, an autoinhibition-defective talin mutant strengthens and stabilizes integr

277 tal cancer (CRC), which can be attributed to defective Th1 and CD8+ T cell responses.

278 arp6a;larp6b double mutant females were more defective than those from larp6a single mutants.

279 etabolic phenotypes that are consistent with defective thermogenesis; innervation can be fully rescue

280 Defective thrombopoiesis and lack of beta4GalT1 further

281 Meanwhile, defective thymic clonal deletion due to altered B7-CD28

282 Despite defective transactivation of canonical target genes, SD-

283 This defective transit from the early endosome disrupts event

284 ous proinflammatory environment, can convert defective Treg cells into powerful, super-activated Treg

285 muscle-specific Speg-knockout (KO) mice have defective triad formation, abnormal excitation-contracti

286 s are assembled inside virions, resulting in defective uncoating of nucleocapsid when infecting new c

287 hippocampal development, which is profoundly defective upon loss of either Lhx2 or Ldb1 Electroporati

288 ssue of Cell, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization

289 ovided by the identification of two division-defective variants of FtsL that still form normal FtsQLB

290 Recent studies have identified defective viral genomes (DVGs) in human infections, incl

291 Arising within this diversity is a subset of defective viral genomes that retain replication competen

292 ogenic virus incorporated into a replication-defective viral particle that contains a sensitive repor

293 To test this, we generated defective viral particles by treatment with HIV-1 protea

294 for their amplification.IMPORTANCE Copyback defective virus genomes (DVGs) are powerful inducers of

295 ary human macrophages infected with cleavage defective viruses.

296 The primary reason for presentation was defective vision (55.2%) followed by routine ophthalmic

297 ctious virus-like particles (VLPs), and that defective VLPs with NP-Ct deletions are significantly re

298 bilities that arise when Und-P metabolism is defective, we developed a genetic screen for synthetic i

299 be therapeutic for inflammatory diseases and defective wound healing associated with aging and diabet

300 Heterologous expression experiments in the defective yeast strain EBY.VW4000 indicated STP13, pGlcT