ライフサイエンスコーパス: defense

1 factor has a distinct role in anti-microbial defense.

2 ted antiviral genes, is a vital part of host defense.

3 etics and environment in the context of host defense.

4 on channels to cGAMP transfer and anti-viral defense.

5 rate the importance of cell movement in host defense.

6 led to ensure timely activation of antiviral defense.

7 host oxidative burst-the first line of plant defense.

8 djuvant to boost inflammasome-dependent host defense.

9 important role in signaling, transport, and defense.

10 g augmented expression of callose-associated defense.

11 a(2+)-dependent, damage-induced plant immune defense.

12 specific selective pressures acting on each defense.

13 orts aimed at improving crop performance and defense.

14 indication of their relevance for antiviral defense.

15 lammasome activation, thereby affecting host defense.

16 [ISGs]) that are integral to antiviral host defense.

17 roup behavior and its importance in predator defense.

18 ial pathogenicity by suppressing host immune defense.

19 tion, C(18)-SMe(2)(+) activates innate plant defense.

20 r the absence of apoptosis in antiviral host defense.

21 ath execution modules involved in organismal defense.

22 eceptors (CLRs) play key roles in antifungal defense.

23 nvolved in Ag presentation and antimicrobial defense.

24 rated a role for MAIT cells in antimicrobial defense.

25 signal receptors critical in development and defense.

26 ere elevated in metabolites related to plant defense.

27 lso reduce consumption through direct pollen defenses.

28 ssential cellular processes to suppress host defenses.

29 edators using both mechanical and behavioral defenses.

30 ects on the host cell that promote antiviral defenses.

31 ed immunity-based strategies to improve host defenses.

32 nfer resistance to both antibiotics and host defenses.

33 h, dissemination, and the countering of host defenses.

34 a significant insult to antimicrobial immune defenses.

35 ogical costs of physical and chemical pollen defenses.

36 the extracellular environment including host defenses.

37 nipulate the ubiquitin system to evade these defenses.

38 rticularly successful in evading our evolved defenses.

39 play a role in surviving intracellular host defenses.

40 on beta expression to initiate innate immune defenses.

41 example, by providing the host with chemical defenses.

42 tes and evolutionarily novel cardenolides as defenses.

43 require multiple infections to bypass CRISPR defenses, a single dose of AcrVIA1 delivered by an indiv

44 versification of these potentially redundant defenses across this genus.

45 ired for TNL signaling, and can also support defense activation during CNL-mediated ETI.

46 ppressing RPW8.1 expression to attenuate its defense activity.

47 biotic stress leads to release EVs with high defense activity.

48 CRISPR functions as a long-term memory-based defense against a diverse landscape of viral species, we

49 e responses, IgE antibodies, and MCs in host defense against a pathogenic bacterium.

50 n factor, mediate innate and adaptive immune defense against a variety of viral infections.

51 hydrogen sulfide (H(2) S) that provides some defense against antibiotics.

52 nfer inceptin-induced responses and enhanced defense against armyworms (Spodoptera exigua) in tobacco

53 ry genes in response to HFD as an endogenous defense against atherosclerosis in ApoE(-/-) model.

54 ted the mechanistic basis of this endogenous defense against atherosclerosis.

55 lymphoid cells (ILC3s) are critical for lung defense against bacterial pneumonia in the neonatal peri

56 inase-I.9), was shown to contribute to plant defense against bacterial, oomycete, and fungal pathogen

57 ible bacteria by acting as the first line of defense against beta-lactam antibiotics, and antibiotic

58 e of Gram-negative bacteria functions in the defense against cytotoxic substances, such as antibiotic

59 drial respiration but also controls cellular defense against ER and oxidative stress.

60 ed NF-kappaB could profoundly influence host defense against fungal pathogens.

61 nigmatic cytokine IL-17F contributes to host defense against fungi.

62 nisms of antibiotic resistance and bacterial defense against host immunity; however, there is little

63 optosis) and plays an essential role in host defense against influenza A virus (IAV) infection.

64 ages (Mphi) are critical for the coordinated defense against invading S. aureus, yet they have a limi

65 hether such AwM play a critical role in host defense against M. tuberculosis infection.

66 represents the immune system's first line of defense against mucosal pathogens.

67 In many bacteria, defense against OG depends on MutT enzymes, which saniti

68 AIM2 plays essential roles not only in host defense against pathogens but also in inflammatory disea

69 al killer (NK) cells are critical for innate defense against pathogens through direct cytotoxicity of

70 repertoire development, to provide lifelong defense against pathogens while maintaining self-toleran

71 luding tissue development and repair, innate defense against pathogens, and generation of adaptive im

72 nate immune system acts as the first line of defense against pathogens, including coronaviruses (CoVs

73 nce of peptidoglycan N-deacetylation on host defense against pathogens, we investigated the virulence

74 is, necroptosis) is an integral part of host defense against pathogens.

75 Programmed cell death contributes to host defense against pathogens.

76 -1Ra) has emerged as a pivotal player in the defense against periodontitis.

77 They play a crucial role in plant defense against phytopathogens by inhibiting microbial p

78 -gated sodium (Na(v)) channels as a chemical defense against predation.

79 tissue-resident memory T cells (TRM) in the defense against recurring pathogens and malignant neopla

80 entify novel host factors important for host defense against S. aureus.

81 fection substantially improved systemic host defense against secondary SA infections in mice.

82 f a single allele of A20 results in enhanced defense against systemic Candida albicans infection and

83 ybean) Sec4 functions in the root during its defense against the parasitic nematode Heterodera glycin

84 vices personnel are a critical first line of defense against the spread of COVID-19.

85 The main line of cellular defense against these electrophilic molecules is conjuga

86 The innate immune response is crucial for defense against viral infections.

87 NK cells provide a defense against virally infected cells using a variety o

88 The interferon system is the first line of defense against virus infection.

89 tive immune systems provide prokaryotes with defense against viruses by degradation of specific invad

90 epithelium plays fundamental roles in immune defenses against enteric viral infections by integrating

91 Bacteria possess an array of defenses against foreign invaders, including a broadly d

92 ell wall modification, thus triggering plant defenses against herbivory.

93 nt system is a crucial part of innate immune defenses against invading pathogens.

94 l clone sizes with implications for pathogen defense and autoimmunity.

95 -density materials, including explosives for defense and construction purposes, as well as propellant

96 coffee bioactives contribute to antioxidant defense and detoxification processes in vivo.

97 mphasize a relevant role of AtNAA50 in plant defense and development, which is independent of the ess

98 ly impacts TB outcome by affecting both host defense and drug metabolism.

99 between growth inhibition at high levels of defense and dysregulation of Trp biosynthesis.

100 neurons in the DMH that is required for cold defense and fever.

101 the pathways and genes associated with plant defense and growth such as jasmonic acid, brassinosteroi

102 ells (PCs) are crucial for epithelial immune defense and highly vulnerable to ischemia-reperfusion in

103 ADP (NADPH) oxidase plays a key role in host defense and immune regulation.

104 We propose that harnessing mast cells' host defense and immunomodulatory properties via the activati

105 while inactivating Nrf2-mediated antioxidant defense and impairing Nrf2-coordinated iron metabolism,

106 ceptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a d

107 ymphoid cells (ILC2s) are implicated in host defense and inflammatory disease, but these potential fu

108 hese compounds have important roles in plant defense and potential commercial applications.

109 rofiling revealed that genes associated with defense and programmed cell death were strongly activate

110 nthetic metabolism is highly integrated with defense and stress signaling pathways, meaning that plan

111 Understanding bacterial defense and survival strategies against one of the most

112 ed by mast cells and has key roles in immune defense and the cardiovascular system.

113 rkable plasticity that is essential for host defense and tissue repair.

114 pridinidae, which use their luminescence for defense and, in Caribbean species, for courtship display

115 n their ability to overcome host nutritional defenses and acquire nutrients.

116 linically significant microbe to bypass host defenses and cause invasive disease.

117 mmune responses that underpin anti-microbial defenses and certain autoimmune diseases.

118 dely known that cigarette smoke damages host defenses and increases susceptibility to bacterial infec

119 ession patterns of different genes linked to defenses and symptoms.

120 portunity for gaining new insights into host defenses and their evolution in an important lab model.

121 hid saliva that elicits effective host plant defenses and warranted the theory of host specialization

122 rowth-defense balance depend on the level of defense, and they further establish an association betwe

123 of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeut

124 circulation, cell trafficking, antimicrobial defenses, and host well-being.

125 Furthermore, host defense antimicrobial peptides and small-molecule peptid

126 le life cycles whereas drought-weakened host defenses appear to have been a distant secondary driver

127 al loads and initial engagement of antiviral defenses are expected.

128 ing the relevance of CD163 for antimicrobial defense as well.

129 tein kinase-phosphatase interaction with the defense-associated calcium-dependent protein kinase CPK1

130 vities were examined by assessing changes in defense-associated phytohormones, specialized metabolite

131 of genes responsive to hypoxia or mediating defense at both low and normal sulfur supply).

132 te the value of mangroves as natural coastal defenses at global, national and local scales, which can

133 the mechanisms underlying JA-mediated growth-defense balance depend on the level of defense, and they

134 ses need to be tightly controlled for growth-defense balance.

135 ISPR-Cas systems provide a uniquely powerful defense because they can adapt to newly encountered geno

136 ecting the interactions between WNV and host defenses both informs basic molecular virology and promo

137 rt innate-like effector function during host defense, but whether MP CD4(+) T cells are functionally

138 etabolic homeostasis while suppressing plant defenses, but the metabolic connections and requirements

139 color) where it plays a key role in chemical defense by releasing toxic hydrogen cyanide upon tissue

140 The exploitation of host innate defenses by herpesviruses during the early phase of host

141 , play a vital role in the host's anti-viral defenses by interfering with viral replication.

142 . pneumoniae, suggesting that this bacterial defense can be overcome.

143 Such defense-counterdefense strategies seem to confer surviva

144 a SARS-CoV-2 assay (Aptima), and the BioFire Defense COVID-19 test (BioFire), to determine analytical

145 Veterans Affairs (VA) and U.S. Department of Defense (DoD) released a joint update of their clinical

146 c signals in mediating plant acclimation and defense during different abiotic and biotic stresses.

147 ignaling contributes critically to host cell defenses during pathogen infection.

148 l as for the response to other non-bacterial defense elicitors.

149 munity and its link to inflammation and host defense encompasses diverse areas of biology, ranging fr

150 otein fibrinogen has been implicated in host defense following Staphylococcus aureus infection, but p

151 arities, general models describing how plant defenses function in ecosystems, and the prioritization

152 nse systems database to organize prokaryotic defense gene datasets.

153 ce salicylic acid and H(2)O(2) accumulation, defense gene expression and cell death in Arabidopsis, a

154 r-triggered immunity (ETI) and regulation of defense gene expression.

155 3 repression leads to the induction of plant defense genes and initiation of SAR.

156 sualize the dynamic variation information of defense genes from pan-genome analysis.

157 -mediated response and hundreds of antiviral defense genes not observed following immunostimulatory t

158 ally predict a diverse set of other putative defense genes that remain to be characterized.

159 rol the expression of salicylic acid-related defense genes, which have recently proven vital in plant

160 and most acylsugar candidate genes, but not defense genes.

161 Among these, herbivore defense has received significant attention, particularly

162 Upregulation of compounds linked to plant defense have negative impacts on sting nematode populati

163 genes (EcLsi1, EcLsi2 and EcLsi6) as well as defense hormone regulating genes (EcSAM, EcPAL and EcLOX

164 Intrinsic host defense immunity is a specialized innate immunity compon

165 ects on the host cell that enhance antiviral defenses.IMPORTANCE Kaposi's sarcoma-associated herpesvi

166 g injury and contribute to dysregulated host defense in CF lung disease.

167 ALAT1, via Keap1-Nrf2, regulates antioxidant defense in diabetic retinopathy.

168 nto the central processes involved in airway defense in health and disease.

169 thelial cells of the gut to orchestrate host defense in homeostasis and following Salmonella infectio

170 ) activation, inflammation and antibacterial defense in P47S macrophages.

171 alance, associated with impaired antioxidant defenses in AD brain.

172 important in understanding innate antiviral defenses in birds.IMPORTANCE Birds are important hosts o

173 Ancestral and novel chemical defenses in Erysimum thus appear to provide complementar

174 o experienced physiological effects of these defenses in the form of hindgut expansion and gut melani

175 o control the induction of hydrogen peroxide defenses in the organism.

176 une system and plays a key role in microbial defense, inflammation, organ development, and tissue reg

177 cells are also key helper cells in antiviral defense, influencing adaptive immune responses via inter

178 isms by which viruses evade host cell immune defenses is important for developing improved antiviral

179 r and regulator of mitochondrial antioxidant defenses, is often suppressed in many primary tumors.

180 epithelial cells to possess highly organized defense machineries, which can jointly regulate host-der

181 In addition to their role in host defense, mast cells contribute to a number of chronic in

182 he findings expand the role of CTRC as a key defense mechanism against pancreatitis through regulatio

183 which suggests that it represents an ancient defense mechanism against viral infections.

184 Silicon amendment induces the synergistic defense mechanism by significantly increasing the transc

185 t-induced gene silencing (HIGS) process as a defense mechanism during natural infection.

186 study will help to understand the molecular defense mechanism for developing strategies for insect p

187 (FNORs) is related to the disruption of the defense mechanism in mammals against invading pathogens.

188 Drosophila uses iron limitation as an immune defense mechanism mediated by conserved iron-transportin

189 role in bacterial growth and act against the defense mechanism of infected hosts.

190 ase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of intr

191 iewing rationalization as a quite suboptimal defense mechanism.

192 efective in its ability to counter the Rab32 defense mechanism.

193 of how gut microbial metabolites affect host defense mechanisms and identify candidate pathways for p

194 mutational burden in males when genome-wide defense mechanisms are compromised, and suggests a previ

195 ite arms race, viruses evolved multiple anti-defense mechanisms including diverse anti-CRISPR protein

196 anding of the innate and activated molecular defense mechanisms involved during compatible and incomp

197 iction-modification systems are well-studied defense mechanisms of bacteria, while phages have evolve

198 teria have evolved diverse posttranslational defense mechanisms to protect their proteins, the main t

199 liae require the ability to escape from host defense mechanisms, in particular complement.

200 uses lung inflammation and can suppress host defense mechanisms, including impairing macrophage phago

201 AhR sensing of TB drugs modulates host defense mechanisms, notably impairs phagocytosis, and in

202 ents (MGEs), bacteria have developed several defense mechanisms, some of which target the incoming, f

203 defense systems, and discusses phage counter-defense mechanisms.

204 These GSLs include allyl-GSL, a defense metabolite that is one of the most widespread GS

205 Glucosinolates (GSLs) are sulfur-containing defense metabolites produced in the Brassicales, includi

206 In this paper, the annually average Defense Meteorological Satellite Program-Operational Lin

207 is a central node of the mammalian predator defense network.

208 dings clearly indicate that RS elicits plant defenses notably as a consequence of SA pathway inductio

209 sence of the master regulator of antioxidant defense nuclear factor erythroid 2-related factor 2 (Nrf

210 Removal of (99)TcO(4)(-) from legacy defense nuclear tank waste at Savannah River Site is hig

211 A positive effect of quebracho regarded the defense of anthocyanin forms, particularly in Sangiovese

212 n (e.g., rigidity of thoughts, hot-cognitive defense of cultural worldviews, and violent rejection of

213 vest anthropogenic mortality (e.g. poaching, defense of property, etc.) was greater in non-harvested

214 lls and constitutes a central element of the defense of the airways against bacterial pathogens.

215 es and therefore represent the first line of defense of the innate immune response.

216 es (AMPs) are essential components of immune defenses of multicellular organisms and are currently in

217 en axis is fundamental to host antimicrobial defense, offer a possible explanation for the clinical o

218 e show that a receptor confers signaling and defense outputs in response to a defined HAMP common in

219 tudied to date, and is linked to territorial defense, paternal care, and courtship.

220 cleavage is antagonized by the 3 major host defense pathways defined by the pmk-1, fshr-1, and zip-2

221 Host-defense peptides have drawn significant attention as new

222 Accordingly, defense phenotypes are dependent on SA synthesis and SA

223 tions to completely uncouple the mild growth-defense phenotypes in a jaz mutant (jazQ) defective in J

224 of host-searching behavior, evasion of plant defenses, plant tolerance to utilization, and sources of

225 th natural and human factors in coastal zone defense policy.

226 ontributes to modulating the PM abundance of defense proteins for effective immune signaling because

227 L) proteins are a widespread family of plant-defense proteins that target these microbial effectors.

228 these defense systems by coding for counter-defense proteins.

229 terial dissemination via proteolysis of host defense proteins.

230 f Military Medicine and the US Department of Defense, Ragon Institute of MGH, MIT, & Harvard, Bill &

231 Our alloimmune defense receptor (ADR) selectively recognizes 4-1BB, a c

232 callose deposition, and targeting the plant defense regulator NPR1 and analyses receptor FLS2.

233 the immunomodulatory and antibiofilm innate defense regulator peptide (IDR)-1018 based on three diff

234 ily, might involve in the transactivation of defense-related genes.

235 , a key factor in first-line innate immunity defense, removes influenza type A virus (IAV) through in

236 torable varieties, mainly in the category of defense response but also in carbohydrate metabolism and

237 onical JA signaling pathway leading to plant defense response in addition to COI1/MYC-independent fun

238 (s) or chromosome intogression and the plant defense response initiated by powdery mildew resistance

239 ction resulted in the induction of AGD2-like defense response protein 1 (ALD1), which encodes an enzy

240 ely regulates RPW8.1-mediated cell death and defense response via suppressing RPW8.1 expression to at

241 , from the early stage, avoiding the plant's defense response, to nodule senescence.

242 is expressed within the syncytium during the defense response.

243 A59 increases RPW8.1-mediated cell death and defense response.

244 ther in the modulation of this complex plant defense response.

245 processes involving regulation of the immune/defense response.

246 ed oxidative stress and improved antioxidant defense response.

247 ated a temporally structured transcriptional defense response.

248 peptides (Peps) are conserved regulators of defense responses and models for the study of damage-ass

249 ted in fat-1 mice in response to EtOH, while defense responses and PPAR signaling were upregulated.

250 y effector proteins that down-regulate plant defense responses and reprogram plant metabolism for col

251 , the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts.

252 lar function and on the fetal cardiovascular defense responses to acute stress.

253 itiate signaling cascades that activate host defense responses.

254 s form an anatomic architecture that confers defense, robustness, and adaptation toward external aggr

255 proteins important for biosynthesis of plant defense secondary metabolites and repressed the accumula

256 tion of the intermediates required for plant defense secondary metabolites to form.

257 However, how NLRs are regulated and activate defense signaling is not fully understood.

258 uter protein N (XopN), a suppressor of early defense signaling.

259 eir interactions, that can target or bolster defense strategies in host-pathogen systems.

260 ansmission has selected for effective immune-defense strategies in insect societies.

261 Prokaryotes have developed numerous defense strategies to combat the constant threat posed b

262 Our findings reveal a counter counter-defense strategy activated by a lncRNA in response to th

263 that diatom spore formation is an effective defense strategy against viral-mediated mortality.

264 IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicat

265 st sensitivity to phage N4, and more generic defenses, such as the overproduction of colanic acid cap

266 transfer to counter evolving bacterial host defenses; such arms race dynamics should lead to diverge

267 This pathway reduces host immune defense, suggesting that the blockade of the beta2-AR si

268 robes without one arm of the adaptive immune defense suggests a high degree of immunological flexibil

269 crophage polarization and contribute to host defense/susceptibility toward infection.

270 Exploitation of the plant defense system against oxidative stress to engineer tole

271 ncluding a broadly distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-base

272 one (GSH), which constitute the most crucial defense system that protects cells from therapeutic agen

273 that KWL1 and KWL1-b are part of a redundant defense system that tissue-specifically targets Cmu1.

274 enal integrates 18 distinctive categories of defense system with the annotation of 6 600 264 genes re

275 NFE2-related factor 2)-regulated antioxidant defense system.

276 Defense systems are vital weapons for prokaryotes to res

277 distinct phages; phages can neutralize these defense systems by coding for counter-defense proteins.

278 en discovered, but there is no comprehensive defense systems database to organize prokaryotic defense

279 So far, numerous types of defense systems have been discovered, but there is no co

280 ples are implemented in a variety of natural defense systems, and discusses phage counter-defense mec

281 dentification of previously undescribed anti-defense systems.

282 ve learned and genetically programmed innate defense systems.

283 oxic self-targeting by endogenous CRISPR-Cas defense systems.

284 tion facilitates de-repression of downstream defense target genes, which involves phosphorylation, in

285 implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell

286 atory tract constitutes an elaborate line of defense that is based on a unique cellular ecosystem.Obj

287 nses, including callose-associated cell wall defenses that are under control by abscisic acid (ABA).

288 and have been shown to be involved in plant defense, their biosynthesis is unclear.

289 s elegans RIG-I-like receptor DRH-1 promotes defense through antiviral RNA interference (RNAi), but l

290 hich has important implications ranging from defense to global Si cycling.

291 ion receptors and genes to counter bacterial defenses to co-exist for each phage.

292 and chemical pollen traits that might act as defenses to limit pollen loss to generalist pollinators.

293 ORTANCE How herpesviruses circumvent mucosal defenses to promote infection of new hosts through the r

294 , ranging from oxygen transportation to host defense, to injury repair.

295 ed mutations that stabilize NRF2, an oxidant defense transcription factor, are predicted to promote t

296 oved models and research approaches to plant defense, trophic interactions, coevolutionary dynamics,

297 increasing aridity and is matched by immune defense, we predict a decrease in innate immune function

298 r proinflammatory mediator important in host defense, whereas resolvins (Rvs) are produced during the

299 gy deficiency, which turns off Nrf2-mediated defense while switching on an Nrf2-operated pathological

300 and provides a first layer of immunological defense within the abdomen.