ライフサイエンスコーパス: defensin

1 lso to proper recognition by this antifungal defensin.

2 refore be unambiguously classified as a beta-defensin.

3 mechanisms, such as IL1B, IL6, IL8, and beta-defensin.

4 ates JAs, (E)-alpha-bergamotene, TPIs, and a defensin.

5 of large gene families and specifically, the defensins.

6 h colchicine to inhibit the release of alpha-defensins.

7 entified regulatory mechanism of Paneth cell defensins.

8 asing antimicrobial proteins including alpha-defensins.

9 sins form a new structural subfamily of beta-defensins.

10 obial peptides, such as polymyxin B and beta-defensins.

11 pared with the already known vertebrate beta-defensins.

12 ral mechanism of toxin inactivation by human defensins.

13 o expands on the known capabilities of human defensins.

14 fide bridge array typical of vertebrate beta-defensins.

15 edict putative antimicrobial activity of our defensins.

16 icrobial peptides polymyxin B and avian beta-defensins.

17 iana significantly up-regulated thionins and defensins.

18 P = .01 and P = .02, respectively), and beta-defensin 1 (DEFB1; rs1800972; P = .001 and P = .0002, re

19 362); and measured the content of human beta-defensin 1 (hBD-1) and hBD-3 messenger RNA (mRNA) in 192

20 tor (VEGF), interleukin-8 (IL-8), human beta-defensin 1 (hBD-1), and tissue inhibitor of metalloprote

21 this study, we demonstrate that murine beta-defensin 1 (mBD1) is important for control of early muco

22 Furthermore, the downregulation of beta-defensin 1 and E-cadherin, and upregulation of hepatocyt

23 eover, H. pylori-induced IL-18 inhibits beta-defensin 1 expression in a NF-kappaB-dependent manner, r

24 significantly downregulated, suggesting beta-defensin 1 plays a crucial role in liver cancer developm

25 Together, our results suggest beta-defensin 1 plays an important role in protecting HCV pro

26 o = 4.31; 95% CI, 1.85-10.1; p= 0.0007; beta-defensin 1 rs1800972, hazard ratio = 3.21; 95% CI, 1.36-

27 ong all the beta-defensins tested, only beta-defensin 1 was significantly downregulated, suggesting b

28 In this study, we demonstrated that beta-defensin 1 was significantly reduced in HCV-infected liv

29 t with that of WT in response to human alpha-defensin 1, mutant kinase F33A did not properly transcri

30 roteins are structured (melittin, human beta defensin 1, truncated human lymphotactin, Cytochrome C,

31 potential therapeutic agents to reverse beta-defensin 1-associated gene signature.

32 also positively correlated with that of beta-defensin 1.

33 tion, and certain AMPs, including human beta-defensins 1-3, have direct fungicidal activity.

34 Rhesus theta (theta) defensin-1 (RTD-1), a natural macrocyclic antimicrobial

35 dase activity and H2O2 production as well as defensin-1 amount was observed in MW-treated samples.

36 olic acid differentially regulate human beta-defensin-1 and -2 secretion by colonic epithelial cells.

37 Given that defensin-1 and H2O2 are regular antibacterial components

38 major bee-derived antibacterial components, defensin-1 and hydrogen peroxide (H2O2).

39 duced antimicrobial proteins S100A9 and beta-defensin-1 in keratinocytes.

40 were no differences in elafin or human beta defensin-1 protein levels between the two groups.

41 th interferon and ribavirin upregulated beta-defensin-1, but not other beta-defensin tested, with the

42 ellogenin, immune system genes apidaecin and defensin-1, stress-related gene catalase and two genes l

43 s to release the antimicrobial peptide alpha-defensin-1, which enhances fibrin polymerization kinetic

44 n egg, including the egg-specific avian beta-defensin 11 (Gga-AvBD11).

45 ctivator receptor related protein-1 and beta-DEFENSIN 14 and the chemokine (C-X-C motif) ligand follo

46 xpress the antimicrobial peptides human beta-defensin 2 (HBD-2) and HBD-3 upon infection with M. tube

47 the role of some of these-such as human beta-defensin 2 (hBD-2) genomic (DEFB4) copy number (CN) vari

48 of the oral cavity, that induces human beta defensin 2 (hBD-2) in primary human oral epithelial cell

49 factor beta1 level increased, but human beta-defensin 2 (HBD-2), HBD-3, and interleukin 8 levels decr

50 on of IL-1beta, IL-6, S100A7, and human beta-defensin 2 (hBD2) and a downregulated expression of the

51 ntimicrobial/host defense peptide human beta-defensin 2 (hBD2) was found to be the mechanism underpin

52 regulation of the gene encoding the AMP beta-defensin 2 (HBD2), taken as a model of possibly specific

53 CH, 15.40; lipocalin 2/FCH, 6.94, human beta-defensin 2 [DEFB4A]/FCH, 4.96; P < .001 for all) and inn

54 hNP-1]), cutaneous beta-defensin (human beta-defensin 2 [hBD-2]), or the platelet kinocidin congener

55 The expressions of filaggrin and human beta-defensin 2 in lesional skin of these patients were marke

56 ffect expression of antibacterial human beta defensin 2 or regenerating islet-derived protein 3-alpha

57 osome-associated membrane glycoprotein, beta-defensin 2, and S100A7; global histopathologic scoring r

58 rk was to study the usefulness of human beta-defensins 2 (BD-2) and 3 (BD-3), which are part of the i

59 er major class of AMPs: i.e., the human beta-defensins 2 (hBD2) and 3 (hBD3).

60 However, higher vaginal levels of beta-defensin-2 lowered the risk of sPTB associated with cerv

61 ominated cervicovaginal microbiota, low beta-defensin-2 was associated with increased risk of sPTB.

62 pithelial antimicrobial peptides (human beta-defensin-2, human beta-defensin-3, cathelicidin LL-37, p

63 expression of the antimicrobial peptide beta-defensin 3 (BD3, Defb3).

64 r groups, and linked with data on human beta-defensin 3 (hBD-3) messenger RNA (mRNA) in skin while ad

65 oferrampin B, MIP3alpha51-70, and human beta-defensin 3 (HBD-3), the latter requiring three disulfide

66 We explored the gamma-core of human beta-defensin 3 (HBD3) and found that it: (a) is the folding

67 gouti signaling protein (ASIP) or human beta-defensin 3 (HBD3) interfere with ATR-pS435 generation, i

68 Human beta-defensin 3 (HBD3), which is produced in the skin, has be

69 d anti-microbial peptides such as human beta-defensin 3 (hBD3).

70 tigated the protective effect of murine beta-defensin 3 (mBD3), mBD4, and the cathelicidin cathelin-r

71 MC1R antagonists human beta-defensin 3 and agouti signaling protein blocked MSH- but

72 induction of the antimicrobial peptides beta-defensin 3, CRAMP, and chemokine CXCL10 and its receptor

73 obial peptides (AMPs), such as LL37 and beta-defensin 3.

74 i from polymyxin B, colistin, and human beta-defensin 3.

75 Human beta defensin-3 (hBD-3), an epithelial cell-derived antimicro

76 the activity of an ASL defensin, human beta-defensin-3 (hBD-3), and the cathelicidin-related peptide

77 efense peptides (HDPs) (LL-37 and human beta-defensin-3), which activate mast cells via Mas-related G

78 peptides (human beta-defensin-2, human beta-defensin-3, cathelicidin LL-37, psoriasin) and cytokines

79 human ASL, and the human cationic AMPs beta-defensin-3, LL-37, and lysozyme to CFA or control.

80 els show that butyrate stimulated human beta defensin-3, mucus components and tight junctions express

81 al effect of hydrogen peroxide or human beta-defensin-3.

82 tibility of Paneth-cell-specific human alpha-defensin 5 (HD-5) and -6 (HD-6) to intestinal proteases

83 or the host barrier, principally human alpha-defensin 5 (HD5) and HD6.

84 Human alpha-defensin 5 (HD5) is an innate immune effector peptide se

85 Synthetic human alpha-defensin 5 (HD5) was orally given to alcohol-fed mice to

86 Recent studies show that human enteric alpha-defensin 5 (HD5), a host defense peptide important for i

87 nteraction of an alpha-defensin, human alpha-defensin 5 (HD5), with HAdV led to a proposed mechanism

88 the cysteine-rich host-defense peptide human defensin 5 (HD5).

89 from BE tissues, most cells did not express defensin-5, Muc-2, or chromogranin A, indicating that th

90 erized the structural features of human beta-defensin 6 (hBD6) and GAG interaction using a combinatio

91 Human alpha-defensin 6 (HD6) is a 32-aa cysteine-rich peptide of the

92 action is described for human enteric alpha-defensin 6, which forms structured nanonets to entrap ba

93 In vivo, alpha defensin administration protected mice from inflammation

94 elucidates a new antiviral action for alpha-defensins against nonenveloped viruses in which HD5 dire

95 omal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease

96 Duodenal E-cadherin (P = 0.03) and defensin alpha 5 (P = 0.03) increased whereas interleuki

97 nit alpha M (integrin adhesive function) and defensin alpha-1 (neutrophil function) increased after p

98 The mode of activity of human defensin alpha-1 against T. cruzi and its function may p

99 fensin alpha-1 to trypomastigotes shows that defensin alpha-1 binds to the flagellum, resulting in fl

100 Short exposure of defensin alpha-1 to trypomastigotes shows that defensin

101 response to a human parasite by secretion of defensin alpha-1, which neutralizes the motility of a hu

102 to Trypanosoma cruzi infection by secreting defensin alpha-1, which reduces infection.

103 Here, we examined the contribution of alpha-defensins (alpha-defs), antimicrobial proteins released

104 ensins and illustrate the potential of theta-defensin analogues as scaffolds for peptide drug design.

105 ized through the diversification of its beta-defensin and butyrophilin-like repertoires.

106 A) to fungal phenotypes, sensitivity to Psd1 defensin and Galleria mellonella virulence.

107 redicted to possess 2 motifs related to beta-defensins and 6 disulfide bridges.

108 d lower expression of REG3gamma but not beta-defensins and Cramp in IECs.

109 s accompanied by enhanced expression of beta-defensins and CRAMP.

110 sights into the mechanism of action of theta-defensins and illustrate the potential of theta-defensin

111 cause an autoimmune response against enteric defensins and loss of Paneth cells.

112 ere upregulated in MG with a predominance of defensins and lysozymes.

113 Samples were assessed for expression of defensins and other molecules by quantitative reverse tr

114 ith BD-2 and BD-3 showed expression of these defensins and presented increased flap survival.

115 ncient and polymorphic gene families such as defensins and receptor-like kinases mediate intercellula

116 es, such as angiogenin 4 and alpha- and beta-defensins and regulated complement activation through ma

117 These defensins and their cognate peptides inhibited conidial

118 ers and active H3K4me3 marks on interleukin, defensin, and chemokine gene promoters, facilitating a r

119 neth cell (PC) antimicrobial peptides, alpha-defensins, and to define the link between PC dysfunction

120 Urinary psoriasin and beta-defensin antimicrobial peptide levels were significantly

121 Human alpha-defensins are 3- to 5-kDa disulfide-bridged peptides wit

122 The beta-defensins are a class of small cationic proteins that se

123 Defensins are a major family of antimicrobial peptides e

124 Defensins are a well-known class of AMPs.

125 alpha-defensins are among the most highly expressed antimicrob

126 Enteric alpha-defensins are antimicrobial peptides secreted by Paneth

127 Alpha defensins are antimicrobial peptides with expression in

128 We investigated whether enteric alpha-defensins are autoantigens in humans and mice with AIRE

129 Defensins are cationic antimicrobial peptides that serve

130 Defensins are components of the innate immune system tha

131 Defensins are cysteine-rich cationic antimicrobial pepti

132 alpha, beta, and theta defensins are effectors of the innate immune system with

133 Human defensins are innate immune defense peptides with a rema

134 embranes, and inactivating bacterial toxins, defensins are known to intercept various viruses at diff

135 Defensins are short cationic, amphiphilic, cysteine-rich

136 Defensins are small antimicrobial peptides capable of ne

137 Defensins are the 'Swiss army knife' in innate immunity

138 tionic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules

139 We identified defensins as novel peanut allergens (Ara h 12 and Ara h

140 l family, dubbed herein as avian-double-beta-defensins (Av-DBD).

141 HFD disrupted the intestinal Mmp7/alpha-defensin axis, which was completely prevented in NT(-/-)

142 The gene encoding HBD2, DEFB4A, is part of a defensin beta (DEFB) cluster on chromosome 8 that is var

143 which are considered hallmarks of psoriasis (defensin beta 4A, kynureninase, and vanin 3).

144 dividual transcripts as primarily epidermal (defensin, beta 4A [DEFB4A]) or dermal (IL22, cytotoxic T

145 Model systems to study defensin biology, including more physiologic models desi

146 for the molecular structures and dynamics of defensin carbohydrate binding.

147 Defensins constitute an evolutionary conserved family of

148 ent bacterial species and identified a novel defensin, copsin.

149 anules containing bactericidal proteins like defensins/cryptdins and lysozyme, PCs regulate the micro

150 sulfide exchange between the canonical alpha-defensin Cys(II)-Cys(IV) (Cys(5)-Cys(20)) bonds located

151 n and specificity expression levels of alpha-defensin (Defa) mRNA in the small intestine of C57BL/6 m

152 Human beta defensin DEFB103 acts as both a stimulant and an attenua

153 dysfunction and AH was investigated in alpha-defensin-deficient mice.

154 MtDef5 consists of two defensin domains of 50 amino acids each linked by a 7-am

155 is a compact fold composed of 2 packed beta-defensin domains.

156 s virions overcome the abundant mucosal beta-defensins during host invasion.

157 can be targeted to induce oligomerization of defensins during membrane permeabilization and demonstra

158 The link between alpha-defensin dysfunction and AH was investigated in alpha-de

159 study suggests that alcohol-induced PC alpha-defensin dysfunction is mediated by zinc deficiency and

160 The equine beta-defensins (eBDs) eBD1, -2, and -3 were produced and secr

161 V1 resisted potent antimicrobial equine beta-defensins (eBDs) eBD2 and eBD3 by the action of glycopro

162 with antibacterial activities including beta-defensins, ELR-negative CXC chemokines, and the cathelic

163 es antimicrobial peptides, such as the alpha-defensins, encoded by DEFA1A3, is important in preventin

164 erent mechanism has been proposed to explain defensins' enigmatic efficiency toward various toxins.

165 contrast to oxidized peptides, some reduced defensins exhibit increased vulnerability to proteolytic

166 Antimicrobial peptides, in particular alpha-defensins expressed by Paneth cells, control microbiota

167 te immune control, mediated in part by alpha-defensins expressed in the genital mucosa, may influence

168 ls restored the attenuated Paneth cell alpha-defensin expression characteristic of patients with ilea

169 ach demonstrated marked differences in alpha-defensin expression in C57BL/6 mice with respect to prox

170 sociations of both DEFB1 haplotypes and beta-defensin expression with S. aureus colonization.

171 ll virus, and Vairimorpha (= Nosema) bombi), Defensin expression, and body size.

172 tion of gut microbiota composition and alpha-defensin expression.

173 w that these novel members of the I. ricinus defensin family differ phylogenetically and structurally

174 We investigated beta-defensin family expression in liver cancer in publicly a

175 This study displays the diversity of the defensin family in the tick I. ricinus.

176 Members of the defensin family of proteins have been reported in severa

177 beta-defensin family plays a role in host defense against vir

178 sis, we identified members of the human beta-defensin family that are both similar and dissimilar to

179 dies of additional members of the human beta-defensin family, examining their potential as ligands of

180 se physiological functions to members of the defensin family.

181 such as lactoferrin and members of the beta-defensin family.

182 helix of two right-handed coiled oligomeric defensin fibrils, the assembly of which is dependent upo

183 s spectrometry and identified several active defensin fragments capable of impacting bacterial growth

184 we describe a total synthesis of PvD(1), the defensin from the common bean Phaseolus vulgaris.

185 ort the identification of six novel putative defensins from I. ricinus at the genomic and transcripti

186 Zinc-regulated PC homeostasis and alpha-defensins function at multiple levels, and dietary zinc

187 f NT in gut microbiota composition and alpha-defensin gene expression associated with obesity.

188 da plays a central role in NT-mediated alpha-defensin gene expression which might be mediated through

189 A haplotype spanning multiple beta-defensin genes and containing 94 SNPs was significantly

190 risation of genetic variation in bovine beta-defensin genes and functional analysis supports a role f

191 ed sequencing (TS) of fertility-related beta-defensin genes and whole exome sequencing (WES).

192 that are prone to structural variation, and defensin genes exhibit extensive copy number variation i

193 tion delay correlated with a decrease in the defensin genes expression suggesting a diminution of ant

194 Defensin genes generally reside in complex genomic regio

195 Copy number variation of defensin genes was examined in inbred lines of Leghorn a

196 GRAIL P < .05), including 3 clusters of beta-defensin genes, 2 chemokine genes (CCL18 and CXCL12), an

197 So far, only two defensins had been identified from I. ricinus.

198 Each defensin has a hallmark gamma-core motif (GXCX(3-9) C),

199 Oligomerization of defensins has been linked to their antimicrobial activit

200 Defensins have direct antiviral activity in cell culture

201 The direct and indirect activities of defensins have led to their development as therapeutics

202 In addition, defensins have potent immunomodulatory activity that can

203 ynthetic theta-defensin RC-101, but not beta-defensins hBD-1 and hBD-2 or structurally related plant-

204 antimicrobial peptides including human beta defensins (HBD) has been reported in the amniotic fluid

205 Enteric ?-defensin HD5 and ?-defensin hBD2 shared similar toxin-unfolding effects wit

206 Human beta-defensins (hBDs) are epithelial cell-derived cationic an

207 crobial peptides (AMPs) including human beta-defensins (HBDs) are expressed by hCVAM and that express

208 Human beta-defensins (hBDs) stimulate degranulation in rat peritone

209 Bile acids and epithelial-derived human beta-defensins (HbetaDs) are known to be important factors in

210 Enteric ?-defensin HD5 and ?-defensin hBD2 shared similar toxin-un

211 Previously, it has been reported that human defensin HD5 inactivates specific human adenoviruses by

212 In humans, the alpha defensin HD5 is produced by specialized epithelial cells

213 study examined the ability of a human alpha defensin, HD5, to neutralize JCPyV infection in human fe

214 ible to destabilizing effects of human alpha-defensins HNP-1 and HD-5 and the synthetic theta-defensi

215 tudy, we showed that binding of neutrophil ?-defensin HNP1 to affected bacterial toxins caused their

216 eutrophil peptide 1 [hNP-1]), cutaneous beta-defensin (human beta-defensin 2 [hBD-2]), or the platele

217 of relevant immune sources: neutrophil alpha-defensin (human neutrophil peptide 1 [hNP-1]), cutaneous

218 uctural study on the interaction of an alpha-defensin, human alpha-defensin 5 (HD5), with HAdV led to

219 d the effect of pH on the activity of an ASL defensin, human beta-defensin-3 (hBD-3), and the catheli

220 action of the most abundant neutrophil alpha defensin, Human Neutrophil Peptide 1 (HNP1).

221 Out of the 14 avian beta-defensins identified in the Gallus gallus genome, only 3

222 ratinocytes, including the induction of beta-defensins, IL-19, IL-23p19, and T helper type 17-cell- a

223 synthesis of PA, is needed for entry of this defensin in N. crassa, but not in F. graminearum.

224 lag is the connection between the effects of defensins in cell culture models and viral pathogenesis

225 functional analysis supports a role for beta-defensins in regulating bull sperm function.

226 using transgenic mice expressing human alpha-defensins in their polymorphonuclear leukocytes (Def(+/+

227 Recently we have found that human defensins inactivate proteinaceous bacterial toxins by t

228 to exerting direct antibacterial activities, defensins inactivate several classes of unrelated bacter

229 ility and conformational plasticity and that defensin-induced unfolding is a key element in the gener

230 Defensin-induced unfolding promoted exposure of hydropho

231 esignated it FAD-I (Fusobacterium-associated defensin inducer).

232 alpha-defensins, molecular details for beta-defensin inhibition are mostly lacking.

233 at protein susceptibility to inactivation by defensins is contingent to their thermolability and conf

234 Accelerated Def(+/+) mice developed alpha-defensin.LDL complexes that accelerate the clearance of

235 d SERPINB13), antimicrobial peptides (e.g. B-defensins like DEFB4A, DEFB4B, DEFB103A, S100 proteins l

236 The nodule cysteine-rich (NCR) groups of defensin-like (DEFL) genes are one of the largest gene f

237 chemotaxis, several of these molecules have defensin-like antibacterial properties.

238 LCE3 proteins, and LCE3A in particular, have defensin-like antimicrobial activity against a variety o

239 ed between conditions and include especially defensin-like genes.

240 iven by host cells through the production of defensin-like peptides called "nodule-specific cysteine-

241 tion domain-containing proteins (NOD2), beta-defensins, macrophages, dendritic cells, mucins, autopha

242 he mode of infection, and that antimicrobial defensins may play a general role in mosquito defense ag

243 AMP; human LL-37 orthologue), and mouse beta defensin (mBD)-3 and -4 (human BD-2 orthologue) was comp

244 d code" that identifies target membranes for defensin-mediated attack as part of a first line of defe

245 ificant mechanistic data are known for alpha-defensins, molecular details for beta-defensin inhibitio

246 The plant defensin, MtDef4, inhibits growth of the ascomycete fung

247 ue gene encoding a highly cationic bi-domain defensin MtDef5 has been identified in a model legume Me

248 dance of chromogranin A, gut hormones, alpha-defensin, mucin 2, Na(+)/glucose co-transporter 1 (SGLT1

249 nism for fungal and tumor cells by the plant defensin NaD1 that acts via direct binding to the plasma

250 here is evidence for paradoxical escape from defensin neutralization or enhancement of viral infectio

251 Here we show that the plant defensin NsD7 targets the phospholipid phosphatidic acid

252 Growing evidence suggests that theta-defensins offer the best opportunity for therapeutic dev

253 studied the effect of human neutrophil alpha-defensins on low density lipoprotein (LDL) trafficking,

254 ng, mucin expression, antimicrobial peptides/defensins, or proinflammatory cytokines in 3-D vaginal e

255 d provide novel structural insights into how defensin orchestrates leukocyte recruitment through GAG

256 informing the antiviral mechanisms of alpha-defensins, our studies highlight the critical role of fu

257 in the number and primary structure of alpha-defensin paralogs.

258 oosing A. thaliana for further analysis, the defensin pathway was enriched, showing additional signal

259 e mode of action and high selectivity, plant defensins (PDs) are worthy therapeutic candidates.

260 laboratories supports the premise that alpha-defensin peptides secreted from Paneth cells are key med

261 ts sequence is related to antimicrobial beta-defensin peptides.

262 dysbiosis due to reduced expression of alpha-defensins, Pigr, and Nox1.

263 Defensins play an important role in plant defense agains

264 plications for our understanding of the role defensins play in melanocortin physiology.

265 Gga-AvBD11 is an atypical double-sized defensin, predicted to possess 2 motifs related to beta-

266 ve NOD2 function can result in reduced alpha-defensin production by intestinal Paneth cells and that

267 beta-Defensins protect the respiratory tract against the myri

268 n epitope-based immunogens based on a cyclic defensin protein, as well as a bivalent immunogen with t

269 lase, proteasomal subunit, or cysteine knot (defensin) protein; and the first report of a prokaryotic

270 nsins HNP-1 and HD-5 and the synthetic theta-defensin RC-101, but not beta-defensins hBD-1 and hBD-2

271 We propose, that defensins recognize and target a common and essential ph

272 eding caused systemic dysbiosis and PC alpha-defensin reduction in mice.

273 microM) inhibited both basal and DCA-induced defensin release.

274 We previously reported that alpha defensins, released from apoptotic human neutrophils, au

275 y HD6 functions differently from other human defensins remains unclear.

276 Results of this study suggest that theta-defensins represent a new class of host-directed compoun

277 theta-Defensin RTD-1 is a noncompetitive inhibitor of anthrax

278 The diversity of defensin-sensitive viral species reflects a multitude of

279 On microbial cell cultures, the peanut defensins showed inhibitory effects on the mold strains

280 functional testing of a subset of these beta-defensins showed that peptides with an HBD3-like electro

281 acked Paneth cells and were seropositive for defensin-specific autoantibodies; the presence of autoan

282 Aire(-/-) mice developed defensin-specific T cells that cause intestinal defects

283 Aire(-/-) mice developed defensin-specific T cells.

284 Knockout of functional alpha-defensins synergistically affected alcohol-perturbed bac

285 egulated beta-defensin-1, but not other beta-defensin tested, with the extent and duration of upregul

286 e datasets and found that among all the beta-defensins tested, only beta-defensin 1 was significantly

287 ater expressions of osteoprotegerin and beta-defensins than group EP (P <0.05).

288 present in the two gamma-core motifs of this defensin that eliminate oligomerization also knockout it

289 MtDef5 is the first bi-domain plant defensin that exhibits potent broad-spectrum antifungal

290 ress in our understanding of alpha and theta-defensins - the two structural classes composed of membe

291 articular, and unlike lantibiotics and other defensins, the third position of the lipid II pentapepti

292 The families included defensins, thionins, hevein-like peptides, snakins, cycl

293 svirus type 1 (EHV1), actually exploits beta-defensins to invade its host and initiate viral spread.

294 When the defensin was ectopically expressed in leaves, performanc

295 The role of zinc deficiency in alpha-defensin was evaluated in acute and chronic mouse models

296 Enteric defensins were detected in extraintestinal tissues of pa

297 ur knowledge, this is the first example of a defensin which inhibits the growth of two ascomycete fun

298 nd CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgro

299 database identified the allergens as peanut defensins, which was confirmed by using mass spectrometr

300 4 from Medicago spp. are small cysteine-rich defensins with potent antifungal activity against a broa