ライフサイエンスコーパス: deficient

1 ing, hypoxic/quiescent and necrotic/nutrient-deficient).

2 m ranelate (625 mg/kg/d) (strontium/estrogen-deficient).

3 racis have mutations rendering them anthrose deficient.

4 chanistic understanding and treatment remain deficient.

5 tive contaminants in soils that are nutrient deficient, a key factor that should be considered in man

6 AM-sufficient (ADM(+/+)) or -deficient (ADM(+/-)) mice were exposed to normoxia or hy

7 stinal bleeding and anemia in inducible ALK1-deficient adult mice.

8 catalysts were evaluated with four electron-deficient alkenes to develop a three-parameter statistic

9 antiproliferative profiles against both BRCA-deficient and BRCA-proficient cancer cells in cellular a

10 Both PRAP1-deficient and E85V knock-in mutant mice fed a chow diet

11 ubtypes (i.e., BRAF-mutant, NRAS-mutant, NF1-deficient, and triple wild-type).

12 Remarkably, almost all IFB-2- and IFC-2-deficient animals develop to fertile adults.

13 In enhancer cluster-deficient animals, Nppa was induced but remained low in

14 Most importantly, in an apolipoprotein E deficient (ApoE(-/-)) atherosclerosis progression murine

15 Some of the salicylic acid-deficient Arabidopsis eds5 mutants have an unnoticed fah

16 Additionally, IL-6-deficient asthmatic mice exhibited reduced goblet cell h

17 ive in vivo inhibition of miR-128-3p in FMRP-deficient astroglia sufficiently rescues decreased mGluR

18 cell types, indicating that ME is not simply deficient at cell-free spread but is particularly effici

19 e and transfer of IL-10-proficient and IL-10-deficient B cells to muMT mice.

20 sregulated CD86 expression in Tet2- and Tet3-deficient B cells was further demonstrated by the restri

21 /B cell-deficient B6.BTg.muMT mice, and BAFF-deficient/B cell-deficient B6.Baff(-/-) muMT mice demons

22 Experiments with BAFF-deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-deficient B

23 B6.BTg.muMT mice, and BAFF-deficient/B cell-deficient B6.Baff(-/-) muMT mice demonstrated that, in a

24 ent B6.muMT mice, BAFF-overexpressing/B cell-deficient B6.BTg.muMT mice, and BAFF-deficient/B cell-de

25 deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-deficient B6.muMT mice, BAFF-overexpressing/B cell-defic

26 in irradiated wild-type recipients of PDIA6-deficient bone marrow cells, both in the absence or pres

27 re and puncture), adoptive transfer of Pink1-deficient bone marrow or pharmacological inhibition of m

28 nic mouse system using otherwise MHC class I-deficient C57BL/6 mice, thereby conditionally ablating M

29 of YAP-driven cancer cells, such as Lats1/2-deficient cancer cells as well as Galpha(q/11) mutated u

30 RP inhibitor combination therapies for BRCA1-deficient cancers than would be identified by traditiona

31 hlight a downstream actionable target in RB1-deficient cancers, for which there are currently no targ

32 cancer therapies in homologous recombination-deficient cancers.

33 xpression of interferon response genes in HR-deficient cancers.

34 or the treatment of MCC and many other STING-deficient cancers.

35 Rh-PPO as a chemotherapeutic targeted to MMR-deficient cancers.

36 the observed Golgi localization of O-glycan-deficient cargos is due to their slow Golgi export.

37 otypic and transcriptomic profiling of c-Maf-deficient CCR6(-) ILC3s revealed a hyper type 1 differen

38 metabolic reprogramming and survival of VHL-deficient ccRCC cells.

39 Moreover, FTO expression is increased in VHL-deficient ccRCC tumors compared to normal adjacent tissu

40 Sensitized wild-type and CD8-deficient (CD8(-/-)) mice were challenged with allergen.

41 e studies increase our understanding of TSC2-deficient cell metabolism, leading to novel potential th

42 XRN2-deficient cells also showed enhanced PARP1 activity.

43 , such as diminished PARPi efficacy in BRCA1-deficient cells and altered repair of damaged telomeres,

44 is abolished in C18orf8-, Ccz1- and Mon1A/B-deficient cells and restored by a constitutively active

45 modulator of stalled fork stability in BRCA2-deficient cells and show that codepletion of RFWD3 rescu

46 otein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replicati

47 SMCHD1-deficient cells displayed reduced ATM S1981 phosphorylat

48 ively reduces the growth and survival of VHL-deficient cells in vitro and in vivo.

49 The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophil

50 C18orf8-deficient cells lack Rab7 activation and show severe def

51 21, and a reduction of mature NPCs in Torsin-deficient cells lead us to conclude that the hallmark ph

52 TET2 knockdown in BRCA2-deficient cells protected stalled replication forks (RFs

53 is poorly understood, it is unclear why BRCA-deficient cells require APE2 for viability.

54 Autophagy-deficient cells secreted increased amounts of type I int

55 The exquisite sensitivity of BRCA-deficient cells to 3' blocks indicates that they represe

56 t, and AKT or ERK1/2 signaling in human TSC2-deficient cells treated with GLPG1690.

57 Using LITAF-deficient cells, a second, subsequent whole-genome CRISP

58 itro, leading to selective cell death in ATM-deficient cells.

59 RNA in zinc-replete cells to LLT HNT1 RNA in deficient cells.

60 lum (ER)-targeted mRNA translation in DIS3L2-deficient cells.

61 of NHEJ-DDR proteins in autophagy- and PTEN-deficient cells.

62 d selectively induce cytotoxicity within MMR-deficient cells.

63 pe, PARP-1 activation is undetectable in AAG-deficient cells.

64 novel pathways of PARPi resistance in BRCA2-deficient cells.

65 functional analysis of human primary SMARCD2-deficient cells.

66 tional component of homologous recombination deficient cellular phenotypes, the image-based algorithm

67 ve been linked to impaired cognition in iron deficient children and adults with neurodegenerative dis

68 Hematopoietic Cx43-deficient chimeric mice show reduced mitochondria transf

69 However, to our surprise, plasmid-deficient Chlamydia failed to produce infectious progeni

70 n that bypasses the gastric barrier, plasmid-deficient Chlamydia produced infectious progenies in sma

71 However, the small intestinal pGP3-deficient Chlamydia sp. failed to reach the large intest

72 intestine, explaining the lack of live pGP3-deficient Chlamydia sp. in rectal swabs following an ora

73 intracolon inoculation, suggesting that pGP3-deficient Chlamydia sp. might be prevented from spreadin

74 Interestingly, pGP3-deficient Chlamydia sp. was able to colonize the colon f

75 CFAP45-deficient cilia and flagella show normal morphology and

76 Patients with MMR-deficient colorectal cancer were excluded.

77 Deficient compared with higher vitamin B-12 was signific

78 In GM-CSF-deficient (Csf2(-/-)) mice, inflammation resolution is d

79 Interestingly, the C-mannosyltransferase-deficient Deltadpy19 parasites were strongly attenuated

80 as relatively unchanged, forming diffuse, HS-deficient deposits in both the Prnp180Q/196Q and WT mice

81 mice were subjected to a methionine-choline-deficient diet causing nonalcoholic fatty liver disease

82 CXCL1/HFD-induced NASH or methionine-choline deficient diet-induced NASH in mice.

83 at diet and in mice fed a methionine-choline-deficient diet.

84 Although PCBP1-deleted livers were iron deficient, dietary iron supplementation did not prevent

85 The oxidized Pol gamma becomes editing-deficient, displaying a 20-fold elevated mutations than

86 Deficient DNA mismatch repair (dMMR) induces a hypermuta

87 ivation in wild-type (Col-0) or rescue of GA-deficient dwarf mutants.

88 Knockdown of Smad7 alleviated deficient ECM production in SA fibroblasts in response t

89 y signals that were in turn enhanced in Lgp2 deficient embryos.

90 ine the mechanisms of IL-10 (interleukin-10) deficient-EPC-derived exosome dysfunction in myocardial

91 bits enhanced mammary tumor development with deficient ERalpha expression that confers tamoxifen resi

92 l activities of the compounds against efflux-deficient Escherichia coli are mediated by LpxA inhibiti

93 utcompete near-cognate suppression in an RF1-deficient expression host and therefore could not produc

94 ing after irradiation is not observed in ATM deficient fibroblasts and may indicate the presence of a

95 We show here that RAD50-deficient fibroblasts exhibit a marked delay in mitotic

96 ry and viral progeny are reduced in vimentin-deficient fibroblasts, compared with control cells.

97 rect stimulation of iNKT cells, we used mice deficient for either MyD88 or the IL-12Rbeta2 in the T c

98 ed neural and inflammatory markers from mice deficient for ELOVL2 (Elovl2(-/-) ), the key enzyme in D

99 tation studies in mouse embryonic fibroblast deficient for Esco1 and Esco2, as a means to identify ca

100 acking the acidic domain reader sequence are deficient for establishment of latency and persistent in

101 Taking advantage of a yeast strain deficient for heme production that enabled controlled mo

102 that arise from BRCA1 germline mutations are deficient for homologous recombination (HR) DNA repair a

103 logy was more dramatic than observed in mice deficient for IL-1beta.

104 M sleep-like cortical activity, whereas mice deficient for neurotensin exhibited increased REM sleep,

105 ions were located in the Rho-GAP domain were deficient for Rho-GAP activity and for suppressing cell

106 anthracis strain or with an isogenic mutant deficient for the protective antigen.

107 Their mice deficient for this p53 phosphorylation were resistant to

108 RIN-deficient fruit never ripened completely, even when supp

109 to reveal that genetic rescue of DNA repair-deficient germ cells (Fancm(-/-) ) leads to increased mu

110 In IFN-gamma(-/-) mice, there is deficient granuloma formation and inducible NO synthase

111 Herein we show that electron-deficient Grignard monomers readily polymerize under vis

112 RAP-stained cells was higher in the estrogen-deficient group than in estrogen-sufficient group at 30

113 activated (hetero)aryl bromides and electron-deficient (hetero)aryl chlorides, and significantly redu

114 culture with isolated mitochondria from Cx43 deficient HSPCs.

115 T cell receptor (TCR) transductants and BTN3-deficient human 293T cells reconstituted with alpaca or

116 ISG15-deficient humans exhibit permanent, low-level expression

117 sis revealed altered gene expression in Tph1 deficient ILC2s including inducible T cell co-stimulator

118 lly extends survival when compared with mice deficient in all sources of IFN-gamma.

119 perfusion recovery during ischemia, and mice deficient in Alx/Fpr2 have an endogenous defect in this

120 in bone marrow-derived macrophages from mice deficient in AMPK (Prkab1(-/)(-)) or ATF1 (Atf1(-/-)).

121 transporter in skeletal muscle, but are not deficient in autophagy.

122 tagging in conjunction with variant proteins deficient in binding their respective direct protein par

123 Mice that lack TLR9 are deficient in both exercise-induced activation of AMPK an

124 Mice deficient in C1q, which fail to properly refine retinoge

125 Plants deficient in CARP9 displayed reduced levels of AGO1-load

126 uman endothelial cells in vitro, we show ECs deficient in CDP-diacylglycerol synthase 2 are uniquely

127 s, we examined survival of S. aureus mutants deficient in central metabolic pathways, including glyco

128 of hypercholesterolemia that were naturally deficient in CETP (cholesteryl ester transfer protein) a

129 We now report that mice deficient in conventional T lymphocytes or recombination

130 Clec9a(-/-) mice deficient in DC cross-priming are protected from persist

131 12), but were still present at day 9 in mice deficient in either AMPK (Prkab1(-/-)) or ATF1 (Atf1(-/-

132 Mice deficient in Fgl2 had dysregulated Ab responses at stead

133 ion of supraspinal motor commands, it may be deficient in freezers during APAs.

134 Ifnar1(S526A) (SA) knock-in mice, which are deficient in IFNAR1 downregulation.

135 brosis-like mucoinflammatory airway disease, deficient in innate lymphoid (Il2rg knockout mice [Il2rg

136 An NF2 mutant deficient in lipid binding is unable to activate the Hip

137 ally, mac1Delta/Delta mutants are profoundly deficient in mitochondrial respiration and Fe accumulati

138 , and a subset of these was identified to be deficient in post-transcriptional steps of chloroplast g

139 When expressed in an Escherichia coli strain deficient in sulfite assimilation, pssm2-Fd complemented

140 We observed that mice deficient in the Ace2 gene (Ace2(-/-) ), developed a clo

141 Consistently, mice deficient in the transcriptional factor T-bet only delay

142 Furthermore, mice deficient in transcriptional factor RORgammat, but not c

143 To this end, mice deficient in type I, II, or III IFN receptors or STAT1 w

144 l replenishment of the vitamin B-12 store in deficient individuals prior to the measurement resulted

145 ATGL-deficient INS1 cells and human pseudoislets showed reduc

146 K27me3 by 50% each time DNA replicates, PRC2-deficient ISCs initially retain sufficient H3K27me3 to a

147 The excision deficient K249Q mutant was even a more potent activator

148 This study included 12 patients exhibiting deficient keratinized tissue (KT) width (i.e., <2 mm) at

149 NIPP1-deficient keratinocytes massively expressed proinflammat

150 Supporting this, P2X4-deficient (KO) mice were protected against ischemic AKI

151 ost of them were generated using replication-deficient lentiviruses, a technique that presents divers

152 erostructure composed of strongly coupled Ni-deficient Li(x)NiO nanoclusters and polycrystalline Ni n

153 n vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone

154 HR-competent Hepa1-GFP hepatoma cells or AHR-deficient LLC lung cancer cells.

155 The ITCH-deficient macrophages had increased levels of the mature

156 the persistence of intact N4BP1 in caspase-8-deficient macrophages impairs their ability to mount rob

157 Reciprocally, Hhex-deficient MBCs exhibited increased Bcl6 expression and r

158 A-binding function of MEF2C, and DNA binding-deficient Mef2c global heterozygous mice display numerou

159 Single-cell transcriptome analysis of Hh-deficient mesoderm revealed selective deficits in anteri

160 ehaviors or SAA1 and SAA2 production in Th17-deficient mice after stress.

161 els demonstrating end-organ protection in C3-deficient mice and evidence of complement activation in

162 after ZIKV challenge in type I IFN receptor-deficient mice and wildtype mice administered neutralizi

163 Colon tumors from IL-17RD-deficient mice are characterized by a strong enrichment

164 her studies, using adult liver-specific G6pc-deficient mice at both pre-tumor and tumor stages, hepat

165 istently, depletion of NK1.1(+) cells in Rag-deficient mice both prevented IFN-gamma production and r

166 hat pathologic microvascular leakage in CD31-deficient mice can be corrected by enhancing the glycoly

167 teral periodontium (gums) of neonatal Magel2-deficient mice compared to wild-type controls.

168 f2 activity is absent in the retina of REDD1-deficient mice compared with WT.

169 elayed replenishment of Treg cells in Vbeta5-deficient mice compromises suppression of microbiota-dep

170 pproaches, and plasma LCB profiling in FADS3-deficient mice confirmed that FADS3 is a bona fide LCB d

171 Primary tumors from Cyp2c44-deficient mice contained higher numbers of tumor-associa

172 Notably, HRI-deficient mice display normal Bcl11a levels, suggesting

173 ApoE/CD163 double-deficient mice displayed a more unstable plaque phenotyp

174 More importantly, microglial mTOR-deficient mice displayed increased neuronal loss and dev

175 In agreement, immature cDC1s in Mycl (-/-) -deficient mice exhibited reduced expression of genes tha

176 onstrate here that PLP(ECD)-immunized B cell-deficient mice failed to exhibit EAE.

177 HFD) feeding for 6 or 18 weeks, WT and AIF1L deficient mice gained weight similarly, showed no differ

178 reviously characterized phenotype of Tmem189-deficient mice may be caused by a lack of plasmalogens.

179 Briefly, FVIII-deficient mice received IV emicizumab 24 hours before ta

180 oliferation of intestinal stem cells in MCL1-deficient mice required WNT signaling and was associated

181 Reduction of IP3R1 in epsin-deficient mice restores atherosclerotic progression.

182 Administration of peptide YY to EEC-deficient mice restores normal electrophysiology, improv

183 ring murine or human proSFTPB cDNA into SP-B deficient mice restores surfactant homeostasis, prevents

184 ligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and di

185 Studies of AIF1L deficient mice showed no obvious postnatal developmental

186 toration of endothelial MHC I rendered MHC I-deficient mice susceptible to lung injury.

187 seminiferous tubules of the testis in ZFP628-deficient mice that results in male infertility.

188 ulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal dev

189 r in vivo studies revealed that myeloid-KLF6-deficient mice were highly resistant to endotoxin-induce

190 Functionally, TICAM2 deficient mice were protected from developing severe sys

191 erent strains of cell-specific conditionally deficient mice were used to compare the role of myeloid-

192 Engraftment of mast cell-deficient mice with Tph1(-/-) mast cells or selective ma

193 nding in the head is mostly intact in Magel2-deficient mice, although it is reduced in the lateral pe

194 In beta-Arr2-deficient mice, bile duct ligation injury (BDL) led to s

195 (OVA)-expressing E.G-7 tumor-bearing immune-deficient mice, intravenously injected Cy5.5-CTLs were c

196 uced a response in both wild-type and T cell-deficient mice, suggesting that it maintains a T-indepen

197 In sensory-specific Piezo2-deficient mice, the distribution of corneal neurons disp

198 lycolytic responses were amplified in LXA(4)-deficient mice, which correlated with more severe pathol

199 against hepatic IR injury in intestinal TLR9 deficient mice.

200 increased post-injury scarring in collagen-V-deficient mice.

201 prostate and skin cancer initiation of Pten-deficient mice.

202 al apoptosis/inflammation in intestinal TLR9 deficient mice.

203 anatomical and synaptic alterations of Ophn1 deficient mice.

204 in pathology, mirroring that observed in Ahr-deficient mice.

205 ld-type ILC2 rescued RSV-driven AHR in IL-13-deficient mice.

206 poptosis after hepatic IR in intestinal TLR9 deficient mice.

207 t hrHPV compared to women with Lactobacillus deficient microbiota.

208 al PDAC samples that exhibit the HNF1A/KDM6A-deficient molecular phenotype.

209 r1(-/-)) bitten by the virus-infected AaVA-1-deficient mosquitoes present a lower viremia and prolong

210 observations, BRF1 overexpression in a Pten-deficient mouse (Pten(Delta/Delta) BRF1(Tg)) prostate ca

211 AMP1 fully rescues the phenotype of the GALC-deficient mouse (Twitcher), and widespread deletion of G

212 nd PI3K signaling pathways are delayed in P2-deficient mouse bone marrow-derived macrophages, mouse e

213 Moreover, PGAM5 deficient mouse embryonic fibroblasts (MEFs) exhibited d

214 rests cardiac differentiation, whereas Hoxb1-deficient mouse embryos display premature cardiac differ

215 We generated a new Nlrc4-deficient mouse line and mice with S533D phosphomimetic

216 s that can reverse microglial defects in Grn-deficient mouse microglia, we performed a compound scree

217 id cell (ILC) number and function in a Dock8-deficient mouse model.

218 were analyzed by using wild-type and B-cell-deficient (muMT) mice and transfer of IL-10-proficient a

219 absent or, possibly, compromised in laforin-deficient murine LD.

220 An APE1 exonuclease-deficient mutant identified in somatic tissue from a can

221 D3 and whether a stabilized, phosphorylation deficient mutant of cyclin D3, has oncogenic activity ar

222 Notably, the expression of the DNA-binding-deficient mutant of NuMA affects chromatin decondensatio

223 genes are differentially expressed in the SA-deficient mutant plant line compared to the wild type an

224 vICA-deficient mutants, lacking either UL36 or M36, exhibit g

225 In upf1-deficient mutants, NMD-susceptible transcripts of riboso

226 AP) sites abolishes higher survival of Mutyh-deficient (Mutyh (-/-)) MEFs, but this blockade had no a

227 Gene expression analysis of mirn23a-deficient myeloid progenitors revealed a decrease in TLR

228 Furthermore, human STAT5b-deficient NK cells had low cytolytic capacity, and fixed

229 blocked anti-insulin vaccine response in SAP-deficient NOD mice.

230 es alkyl radicals for coupling with electron-deficient olefins for the generation of unnatural gamma-

231 are significantly decreased in the TMEM106B-deficient Oli-neu oligodendroglial precursor cell line.

232 h compared to those injected with gingipain-deficient OMVs or controls.

233 RNA sequencing was performed on strains with deficient or excessive PE biosynthesis to elucidate the

234 Hdac3-deficient osteoclasts demonstrate increased K310 NF-kapp

235 at heat-induced DV destabilization in PI(3)P-deficient P. falciparum precedes cell death and is rever

236 phosphorylation in vivo, new phosphorylation-deficient p53-S180A knock-in mice were generated.

237 se III in neuroepithelial cilia, implicating deficient pathway repression.

238 imilar to the biochemical picture in ALDH7A1-deficient patients.

239 ai stacking interaction between the electron-deficient pentafluorophenyl ring and electron-rich napht

240 Cultured Olfml3-deficient pericytes exhibited aberrant motility and alte

241 fied previously, but only aba4 exhibited ABA-deficient phenotypes.

242 ormal pooled plasma, as well as FXII- or FXI-deficient plasma, but not FIX-deficient plasma.

243 s FXII- or FXI-deficient plasma, but not FIX-deficient plasma.

244 /6(-/-) pmLF and ROCE was similar in STIM1/2-deficient pmLF compared to Wt cells.

245 nd reveal the therapeutic potential of ISG15-deficient porcine and rhesus models.

246 -directed agents, we created a series of ATM-deficient preclinical prostate cancer models and tested

247 ubstitutions in the homologous recombination-deficient Rad51 mutant, specifically dependent on the Po

248 therapeutic target for the treatment of VHL-deficient renal cell carcinoma.

249 s as a top enriched class of genes in Rbfox2-deficient retinas.

250 introduced mtDNA is stably retained in mtDNA-deficient (rho0) recipient cells following uridine-free

251 re greatly decreased in adr-1 mutants due to deficient RNA editing at a single adenosine in their 3'-

252 Lesch-Nyhan disease (LND), caused by a deficient salvage purine pathway, is characterized by se

253 not occur efficiently in vivo and that Galc-deficient Schwann cells autonomously produce psychosine.

254 esses using a model of TLR priming in a TAK1-deficient setting to mimic pathogen-induced priming and

255 nge activity is resuscitated in heme binding-deficient Sfh5 mutants.

256 gen-sufficient); ovariectomy+water (estrogen-deficient), sham-surgery+strontium ranelate (625 mg/kg/d

257 SPEG-deficient skeletal muscles contained fewer myogenic cell

258 ermal, fibroblast, and immune cells of Ovol1-deficient skin that reflect an altered course of epiderm

259 The deficient sodium in the P2-type cathode easily induces t

260 nservation voids for Caprinae and other data-deficient species inhabiting rugged or heavily vegetated

261 ein were markedly reduced in Src-1/-2 double-deficient (Src-1/-2(d/d) ) fetal lungs, compared to WT.

262 vehicle, TSLPR(-/-) mice, and IL-33 receptor-deficient (ST2(-/-) ) mice were challenged intranasally

263 RNA RsaD is overexpressed >20-fold in a CodY-deficient strain in three S. aureus clinical isolates an

264 Nonetheless, RIP-deficient strains have over an order of magnitude fewer

265 CfrA overexpression is also observed in PII-deficient strains; however, it is lethal in this genetic

266 gands such as dimethyl fumarate and electron-deficient styrenes afford primarily beta-hydride elimina

267 Distinctly, the most electron-deficient superoxo adduct is observed to react the faste

268 In the presence of co-stimulation-deficient T cell activation, anergy is a dominant hallma

269 TIPE-deficient T lymphocytes are completely pilot-less: they

270 Using Tbet-deficient (Tbet KO) mice, we showed a partial role for T

271 Compared with wild-type, VHL-deficient Th17 cells had elevated glycolysis and glycoly

272 expression of genes related to axonogenesis, deficient thalamocortical axons and impaired outgrowth o

273 m the electron-rich pyrene (Py) and electron-deficient thiazolo[5,4-d]thiazole (Tz).

274 Despite this, migration defects of WNK1-deficient thymocytes do not account for the developmenta

275 In mice with Bcl6-deficient Treg cells, twice as many ST2(+) (IL-33R(+)) T

276 BALB/c WT and TSLP receptor-deficient (TSLPR(-/-) ) mice were challenged intranasall

277 The flavonol-deficient tt4 mutant has elevated ROS in trichoblasts an

278 eased apoptosis were observed in alpha3beta1-deficient tumor cells, these changes followed a robust i

279 le vulnerability in homologous recombination-deficient tumor cells.

280 The PTEN/TP53-deficient tumor demonstrates treatment resistance, selec

281 pathway was essential for the growth of p53-deficient tumor organoids.

282 beled surrogate of PEG~TLZ in the MX-1 BRCA1-deficient tumor.

283 BAP1-deficient tumors exhibit deregulation of the Hippo pathw

284 co-targeting MK2 and XPA to pre-existing p53-deficient tumors in a highly aggressive, immunocompetent

285 Rapid growth of BAP1-deficient tumors indicates that these patients should be

286 not led to effective strategies to treat RB1-deficient tumors, as it is challenging to develop target

287 and immunostimulatory reprogramming of Prox1-deficient tumors, destroyed tumor fibrosis, and unleashe

288 al therapy to treat homologous recombination-deficient tumors.

289 (468/484) specificity; 64% MSI-H and 73% MMR deficient tumours unexplained by LS or MLH1-hypermethyla

290 r pathways need to be explored to treat p53- deficient tumours.

291 he helicase-nuclease Cas3(4,5), but nuclease-deficient type I systems lacking Cas3 have been repurpos

292 Generation of the oxygen-deficient vanadium oxide, [V(6)O(6)(OC(2)H(5))(12)](1-),

293 1)-receptor and A(1)R-Y288A(7.53) (a folding-deficient variant used as a reference), respectively.

294 tion in Ptgs2 (Ptgs2(Y385F) mice), mast cell-deficient (W/W(V)) mice, and W/W(V) mice given injection

295 Early-postpartum cows were metabolically deficient with a significantly lower energy balance and

296 , the loss of which has been associated with deficient XCI at multiple loci(2-6).

297 Insertion of an ERV into an A-repeat deficient Xist rescues binding of Xist RNA to Spen and r

298 We further demonstrated that juvenile csf1r-deficient zebrafish exhibit systemic macrophage depletio

299 se two cell fates during aging of telomerase deficient zebrafish.

300 formed at the interface of Pt NPs and linker-deficient Zr(6)O(8) nodes resting on the Pt NP surface.