ライフサイエンスコーパス: deficient mice

1 ate transport in intestinal-depleted Slc34a2-deficient mice.

2 nce that DN T cells can differentiate in MHC-deficient mice.

3 creased in the olfactory bulb of aged Carns1-deficient mice.

4 pionate levels were lower in intestinal TLR9 deficient mice.

5 al bone formation rate was displayed in CCR3-deficient mice.

6 stnatal development of hydrocephalus in Gldc-deficient mice.

7 the neural retina from wildtype and Ca(v)2.3-deficient mice.

8 23 can explain the renal response in Slc34a2-deficient mice.

9 testosterone reduced red cell count in iron-deficient mice.

10 R6(-/-) mice but was negative for other gene-deficient mice.

11 against hepatic IR injury in intestinal TLR9 deficient mice.

12 mouse macrophages from Aster-B and Aster-A/B-deficient mice.

13 ss in a tail-clip-bleeding model using FVIII-deficient mice.

14 increased post-injury scarring in collagen-V-deficient mice.

15 MDAR function and social behaviors in Shank3-deficient mice.

16 tact or are only partially reduced in Piezo2-deficient mice.

17 n late embryonic and neonatal livers of Jag1-deficient mice.

18 ) cells and MDSCs within bone marrow of CCR2-deficient mice.

19 -9 in the retina of WT mice but not in REDD1-deficient mice.

20 rtially rescued alveolar phenotypes in Gorab-deficient mice.

21 in vivo using p53-/- and p53/REGgamma double-deficient mice.

22 n and restored insulin signaling in the CD36-deficient mice.

23 r injury using fumarylacetoacetate hydrolase-deficient mice.

24 fetal loss in wild-type mice but not in TLR4-deficient mice.

25 prostate and skin cancer initiation of Pten-deficient mice.

26 nduced bloom of Enterobacteriaceae in immune-deficient mice.

27 nvolved in neural signaling in PFC of Shank3-deficient mice.

28 f beta2 integrins in HSPCs phenocopies mDia2 deficient mice.

29 esulting in perinatal death of 35% of Olfml3-deficient mice.

30 ither IL-17A-deficient or NGAL/IL-17A double-deficient mice.

31 increase in fibrin(ogen) in the plasminogen-deficient mice.

32 al apoptosis/inflammation in intestinal TLR9 deficient mice.

33 anatomical and synaptic alterations of Ophn1 deficient mice.

34 in pathology, mirroring that observed in Ahr-deficient mice.

35 cterized the immune cell functions of DUSP11-deficient mice.

36 nsion of the NSC population observed in CCN1 deficient mice.

37 igh-fat diet (HFD) which were improved in NT-deficient mice.

38 on and AH was investigated in alpha-defensin-deficient mice.

39 ld-type ILC2 rescued RSV-driven AHR in IL-13-deficient mice.

40 factory system and skeletal muscle of Carns1-deficient mice.

41 ogenic effects of TWEAK in ApoE/CD163 double-deficient mice.

42 e retina isolated from wildtype and Ca(v)2.3-deficient mice.

43 gate pathway for complement activation in C3-deficient mice.

44 ythropoiesis in iron-replete as well as iron-deficient mice.

45 poptosis after hepatic IR in intestinal TLR9 deficient mice.

46 pared 1) T cells from LAIR-1-sufficient and -deficient mice, 2) Jurkat cells expressing either LAIR-1

47 Following injection into apoA-I-deficient mice, 5-OHTrp(72) apoA-I reached plasma levels

48 phenotypes were unaffected in Notch1/2 dimer-deficient mice, a subset of tissues proved highly sensit

49 In vivo kynurenine supplementation in IDO-deficient mice abrogates the protective effects of IDO d

50 ry response as observed in global IL-4Ralpha-deficient mice after intranasal allergen challenge.

51 ehaviors or SAA1 and SAA2 production in Th17-deficient mice after stress.

52 ll priming in nitric oxide synthase 2 (NOS2)-deficient mice all failed to reveal an effect of P2C/5-O

53 nding in the head is mostly intact in Magel2-deficient mice, although it is reduced in the lateral pe

54 Using lymphocyte-deficient mice and a series of adoptive transfer experim

55 We generated endothelial Fto-deficient mice and analyzed the impact of obesity on tho

56 Exophilin-5-deficient mice and asthma mouse models revealed that exo

57 sed in the prefrontal cortex (PFC) of Shank3-deficient mice and autistic human postmortem brains.

58 els demonstrating end-organ protection in C3-deficient mice and evidence of complement activation in

59 (p = 0.015), and phagocytosis assays in MPO-deficient mice and human cells revealed altered neutroph

60 te secretion in islets from the KATP channel-deficient mice and in other models of KATP deficiency, i

61 dibehenate was specifically abrogated in TNF-deficient mice and strongly attenuated by TNF blockade w

62 The use of TNF-deficient mice and those that express only membrane-asso

63 after ZIKV challenge in type I IFN receptor-deficient mice and wildtype mice administered neutralizi

64 MyD88-deficient mice and zebrafish were not only impaired in t

65 in wild-type and intestinal-specific Slc34a2-deficient mice, and analysed trans- vs. paracellular rou

66 tion into the CNS was inhibited in cortactin-deficient mice, and lack of cortactin in cultured primar

67 cue of autism-like social deficits in Shank3-deficient mice, and restored NMDAR-mediated synaptic fun

68 METTL5-deficient mice are born at non-Mendelian rates and devel

69 Colon tumors from IL-17RD-deficient mice are characterized by a strong enrichment

70 We previously showed that calnexin (Canx)-deficient mice are desensitized to experimental autoimmu

71 We find that NAIP-NLRC4-deficient mice are highly susceptible to oral Shigella i

72 We demonstrate that L-selectin-deficient mice are prone to pulmonary infection compared

73 e consider possible explanations for why MCU-deficient mice are spared from energy crises under physi

74 her studies, using adult liver-specific G6pc-deficient mice at both pre-tumor and tumor stages, hepat

75 hepatocytes in fumarylacetoacetate hydrolase-deficient mice at the time of liver injury via hydrodyna

76 In Tgammadelta17 cell-deficient mice, basal keratinocyte transcriptome was alt

77 However, testosterone worsens anemia in iron-deficient mice because of ineffective erythropoiesis pos

78 In beta-Arr2-deficient mice, bile duct ligation injury (BDL) led to s

79 istently, depletion of NK1.1(+) cells in Rag-deficient mice both prevented IFN-gamma production and r

80 ion of NK1.1(+) cells from adaptive immunity-deficient mice both significantly reduced IFN-gamma and

81 in the CNS of oligodendrocyte-specific Sel1L-deficient mice (both male and female).

82 in the CNS of oligodendrocyte-specific Sel1L-deficient mice (both male and female).

83 Cl(2) is absent in the retinae from Ca(v)2.3-deficient mice, but prominent in Ca(v)2.3-competent mice

84 enetic rescue of FXS-like phenotypes in FMRP-deficient mice by deletion of the Cpeb1 gene is mediated

85 es genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (H

86 embryonic lethality of dually PARP-1/PARP-2-deficient mice by using a PARP-1-deficient mouse with a

87 hat pathologic microvascular leakage in CD31-deficient mice can be corrected by enhancing the glycoly

88 We and others have observed that B cell-deficient mice challenged with Brucella display reduced

89 Remarkably, both Canx-deficient and Fabp5-deficient mice commonly manifest resistance to EAE induc

90 teral periodontium (gums) of neonatal Magel2-deficient mice compared to wild-type controls.

91 d IL-6 were significantly elevated in DUSP11-deficient mice compared with those of wild-type mice.

92 s applied on the cornea were lower in Piezo2-deficient mice compared with wild type.

93 n was reduced in AECIIs from Tmprss2/Tmprss4-deficient mice compared with WT or Tmprss2-deficient mic

94 f2 activity is absent in the retina of REDD1-deficient mice compared with WT.

95 Reconstitution of wild type (WT) AAMs to ST2-deficient mice completely restores bronchial re-epitheli

96 elayed replenishment of Treg cells in Vbeta5-deficient mice compromises suppression of microbiota-dep

97 pproaches, and plasma LCB profiling in FADS3-deficient mice confirmed that FADS3 is a bona fide LCB d

98 Primary tumors from Cyp2c44-deficient mice contained higher numbers of tumor-associa

99 l alveolar lavage fluid from infected IL-8R2-deficient mice contained more IL-17A and interferon-gamm

100 Total knockout of P2X7Rs in MECP2 deficient mice decreases the number of inflammatory myel

101 Studies in Synpo-deficient mice demonstrated exacerbated disease suscepti

102 In conditional, RGC specific Opa1-deficient mice, depletion of the essential autophagy gen

103 hies were intensified in the brains of Trem2-deficient mice, despite these mice displaying reduced pl

104 LXRalphabeta-deficient mice develop a fatty, rapidly involuting thymu

105 Untreated SP-B deficient mice develop fatal respiratory distress within

106 omyelitis model of multiple sclerosis, TAGAP deficient mice develop significantly attenuated disease.

107 Allo TIPE-deficient mice developed exacerbated gut GVHD compared w

108 determine the mechanism by which caspase-11-deficient mice developed reduced pathology, the chlamydi

109 White adipose tissue of HF/HC-fed ALR-deficient mice developed strong inflammation, indicating

110 at in contrast to WT mice, diabetic 4E-BP1/2-deficient mice did not exhibit enhanced retinal Cd40 mRN

111 2 (IL-2) receptor common gamma chain in Rag-deficient mice did rescue mutant colonization.

112 HDAC1-deficient mice display age-associated DNA damage accumul

113 We further show that Klf10 deficient mice display enhanced liver injury and fibrosi

114 Notably, HRI-deficient mice display normal Bcl11a levels, suggesting

115 We show here that Hmces-deficient mice display normal hematopoiesis without glob

116 ApoE/CD163 double-deficient mice displayed a more unstable plaque phenotyp

117 e outgrowth of these cells, we found that C3-deficient mice displayed a significantly reduced tumor b

118 beta(2)-integrin-deficient mice displayed a striking increase in numbers

119 Spleens of TFR2-deficient mice displayed an increase in colony-forming u

120 More importantly, microglial mTOR-deficient mice displayed increased neuronal loss and dev

121 mEar1 protein, but not eosinophils from IL4-deficient mice, effectively correct exacerbated cardiac

122 (flox/flox)/CD4-cre(tg) (/wt) mice into Rag2-deficient mice elicited more severe colitis associated w

123 In iron-deficient mice, erythropoietin levels were higher but er

124 ng Listeria monocytogenes infection, as P2X5-deficient mice exhibit increased bacterial loads in the

125 the role of SMOX, and demonstrate that Smox-deficient mice exhibit significant reductions of gastric

126 Olfml3-deficient mice exhibited abnormalities in the vasculatur

127 In contrast, aging (18-24-month-old) Carns1-deficient mice exhibited olfactory sensitivity impairmen

128 Sb9-deficient mice exhibited protective T cell-based host im

129 In agreement, immature cDC1s in Mycl (-/-) -deficient mice exhibited reduced expression of genes tha

130 t the alleviation of skin inflammation, KLK7-deficient mice exhibited significantly attenuated scratc

131 CUL3-deficient mice exhibited social deficits and anxiety-lik

132 Whereas P2X5-deficient mice experience normal monocyte recruitment in

133 onstrate here that PLP(ECD)-immunized B cell-deficient mice failed to exhibit EAE.

134 pectroscopy, engineered cells, and RGD motif-deficient mice (Fn1DeltaRGD/DeltaRGD) to search for addi

135 Rel expression in B cells of otherwise c-Rel-deficient mice fully rescued terminal B cell differentia

136 HFD) feeding for 6 or 18 weeks, WT and AIF1L deficient mice gained weight similarly, showed no differ

137 In osteopontin-deficient mice, global matrix phosphorylation level was

138 In NK cell-deficient mice, granulocyte colony-stimulating factor-ex

139 Instead, myeloid LKB1 deficient mice had AMs with a 'non-classical' (SiglecFlo

140 IL-8R2-deficient mice had fewer neutrophils in infected lungs t

141 s than controls, but unexpectedly the IL-8R2-deficient mice had fewer organisms in their lungs than t

142 function data suggest that obesity-prone ALX deficient mice had impaired myocardium strain.

143 Myeloid, but not neutrophil LKB1 deficient mice had increased bacterial loads in lungs fr

144 vated receptor alpha), and livers from Ilrun-deficient mice had increased PPARalpha protein.

145 In this study, we found that STING-deficient mice had increased weight loss and roughly 10-

146 In contrast, NLRP3- or IL18-deficient mice had reduced activation of T cells and no

147 ype mice, WD-fed TCRdelta-deficient and CCR6-deficient mice had reduced skin inflammation and IL-17A

148 Thymic stromal lymphopoietin receptor deficient mice had significantly decreased the number of

149 In experimental sepsis, MAIT-deficient mice had significantly increased mortality and

150 Accordingly, cortactin gene-deficient mice had smaller numbers of proinflammatory cu

151 As a consequence, TIPE-deficient mice have a marked defect in positioning their

152 Dock2-deficient mice have a pronounced expansion of their memo

153 SPARC-deficient mice have been shown to exhibit impaired gluco

154 ll levels, and studies in IgM- and/or B cell-deficient mice have demonstrated increased Cryptococcus

155 se experimental autoimmune encephalitis, p73-deficient mice have increased IFNgamma production and le

156 onths of age, both OHCs and IHCs of Baiap2l2 deficient mice have lost most of the second and third ro

157 species (ROS) production, rendering ORAI1/2-deficient mice highly susceptible to staphylococcal infe

158 In SOD3-deficient mice, hypoxia increased lung hyaluronidase exp

159 -CD8 were robustly suppressive in IFN-gammaR-deficient mice, IFN-gammaR-deficient PLP-CD8 exhibited s

160 IL-2Ralpha deficient mice (IL-2Ralpha-KO) develop systemic autoimmu

161 IL-36R-deficient mice (Il1rl2 (-/-) ) exhibited significant imp

162 Using a range of complement-deficient mice in a two-stage mouse model of chemically-

163 In this report, we analyzed TFR2-deficient mice in the presence or absence of iron overlo

164 cytic phagocytosis was also observed in Irf8-deficient mice, in which microglia were present but dysf

165 Testosterone treatment of iron-deficient mice increased the ratio of early-to-late eryt

166 sidual inflammation induced by PLY in 12-LOX-deficient mice indicates that 12-LOX-independent pathway

167 D or inducible NO synthase-, CD40-, or IL-12-deficient mice, indicating attenuation.

168 ppressed MDSC-like cell accumulation in IRF8-deficient mice, indicating that DNA methylation may regu

169 4-deficient mice compared with WT or Tmprss2-deficient mice, indicating that murine TMPRSS4 is involv

170 ed tumor growth in wild-type, but not in LXR-deficient mice, indicating that the antitumor effects of

171 (OVA)-expressing E.G-7 tumor-bearing immune-deficient mice, intravenously injected Cy5.5-CTLs were c

172 ere, we showed that ventriculomegaly in Gldc-deficient mice is preceded by stenosis of the Sylvian aq

173 In the ventral striatum of CHL1-deficient mice, levels of phosphorylated DARPP32 were re

174 Lmo4-deficient mice (Lmo4gt/+) consumed significantly more an

175 However, we show herein that FasL-deficient mice lose bone mass following ovariectomy indi

176 We find that Baiap2l2 deficient mice lose their second and third rows of stere

177 In the dorsal striatum of CHL1-deficient mice, lower levels of DRD2 and phosphorylated

178 Consequently, MLKL-deficient mice manifest reduced nuclear disruption of lu

179 reviously characterized phenotype of Tmem189-deficient mice may be caused by a lack of plasmalogens.

180 For dendritic cells derived from STING-deficient mice, no activation was detected.

181 ollowing intrarectal exposure to TcdA/B, PXR-deficient mice (Nr1i2(-/-) ) exhibited reduced survival,

182 ly infected interleukin-8R2 (IL-8R2) (Cxcr2)-deficient mice on a BALB/c background with Coccidioides

183 tion in the brachiocephalic arteries of ApoE-deficient mice on high-fat diet.

184 on in resistance arteries of endothelial Fto-deficient mice on high-fat diet; conversely, direct addi

185 xic lymphocytes: it is abrogated in perforin-deficient mice or mice depleted of killer lymphocytes.

186 marrow-derived macrophages (BMDMs) from BTK-deficient mice or monocytes from patients with X-linked

187 tosis using mixed lineage kinase domain-like deficient mice or necrostatin-1s treatment protected fro

188 Moreover, cells isolated from DNA-PKcs-deficient mice or patients carrying PRKDC missense mutat

189 In Baiap2l2 deficient mice, outer hair cells (OHCs), but not inner h

190 icide, showed superior persistence in immune-deficient mice pretreated with DARA, and enhanced ADCC a

191 hile transfers from WT littermates into Arg1-deficient mice prevented an advanced recovery from colit

192 IV injections of C-miR146a mimic to miR-146a-deficient mice prevented excessive NF-kappaB activation

193 rast, Pik3ca-null tumors implanted in T cell-deficient mice progressed and killed all of the animals.

194 ained in the visual cortex of adult PTPsigma-deficient mice (PTPsigma(+/-)).

195 Moreover, heterozygous Zmym2-deficient mice recapitulated features of CAKUT with high

196 Briefly, FVIII-deficient mice received IV emicizumab 24 hours before ta

197 n (RSV) on atherogenesis in Apolipoprotein E-deficient mice receiving silk ligature placement around

198 IL-17A-deficient chimeras compared with MPO-deficient mice receiving wild-type bone marrow, as well

199 Using ArhGAP15-deficient mice, reduced neutrophil adhesion and transmig

200 stress erythropoiesis was stimulated in iron-deficient mice relative to iron-replete mice, and furthe

201 oliferation of intestinal stem cells in MCL1-deficient mice required WNT signaling and was associated

202 Genetic deletion of Spp1 in Snai2-deficient mice rescues MSPCs' functions.

203 based transduction of Dnase1l3 into Dnase1l3-deficient mice restored the end motif profiles to those

204 Reduction of IP3R1 in epsin-deficient mice restores atherosclerotic progression.

205 Administration of peptide YY to EEC-deficient mice restores normal electrophysiology, improv

206 at activation of this projection in Ca(v)1.2-deficient mice restores reinstatement.

207 ring murine or human proSFTPB cDNA into SP-B deficient mice restores surfactant homeostasis, prevents

208 ralizing antibody against IL17 to neutrophil-deficient mice resulted in development of less-invasive

209 MCMV infection of tumors in STING-deficient mice resulted in normal recruitment of macroph

210 SB formation, and in PRDM9 methyltransferase deficient mice reveal that 5hmC is triggered at DSB-pron

211 uted tomography analyses of femurs from CCR3-deficient mice revealed a bone phenotype that entailed l

212 Analysis of bone marrow from TFR2-deficient mice revealed a reduction in the early burst-f

213 dendritic cells from C-type lectin receptor-deficient mice revealed that the immunostimulatory activ

214 ligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and di

215 aging to evaluate wild-type (wt) and SHARPIN-deficient mice (Sharpin (cpdm) , where cpdm = chronic pr

216 ndent, and that gasdermin-D and caspase-1/11 deficient mice show deficits in brain inflammation and p

217 Consequently, Miwi-deficient mice show elevated aneuploidy in metaphase II

218 Adipoq-deficient mice show increased rest phase food intake ass

219 We demonstrate that Pogz deficient mice show microcephaly, growth impairment, inc

220 B cell-specific cullin 3-deficient mice show reduced developing B cells in the bo

221 IL-33- and IL1RL1-deficient mice showed defective iron recycling and incre

222 Enhancer cluster-deficient mice showed enlarged hearts before and after b

223 Specifically, when treated with DSS, Mn-deficient mice showed increased morbidity, weight loss,

224 use calvarial osteoblasts isolated from CCR3-deficient mice showed increased mRNA expression of the o

225 Par4-deficient mice showed less myocyte apoptosis, reduced in

226 Studies of AIF1L deficient mice showed no obvious postnatal developmental

227 helial debridement experiments in young ACE2-deficient mice showed normal appearing corneas, devoid o

228 xperimental evidence derived from Pcdh-gamma-deficient mice shows that they are involved in dendrite

229 a chain (IL-2Rgammac) from adaptive immunity-deficient mice significantly compromised the endometrial

230 epletion of IFN-gamma from adaptive immunity-deficient mice significantly compromised the endometrial

231 vo studies with epithelial-specific versican-deficient mice [SPC-Cre(+) Vcan(-/-)] demonstrated that

232 ural killer cell receptor (NCR1), since NCR1-deficient mice still inhibited mutant colonization.

233 Accordingly, we have found that Grasp55-deficient mice suffer from spermatogenesis defects simil

234 ion patterns in DN3 cells from Wt and Arid1a-deficient mice suggested that the developmental block re

235 uced a response in both wild-type and T cell-deficient mice, suggesting that it maintains a T-indepen

236 D(3) administration had no effect in Slc34a2-deficient mice, suggesting that the hormone specifically

237 response in wild-type mice but not in T cell-deficient mice, suggesting that the response is dependen

238 toration of endothelial MHC I rendered MHC I-deficient mice susceptible to lung injury.

239 seminiferous tubules of the testis in ZFP628-deficient mice that results in male infertility.

240 ulates skull development, we generated Rab23-deficient mice that survive to an age where skeletal dev

241 In sensory-specific Piezo2-deficient mice, the distribution of corneal neurons disp

242 In Tbx1-deficient mice, the spheno-occipital synchondrosis was c

243 Conversely, in MHC and CD4/CD8 coreceptor-deficient mice, the thymus generates mature T cells expr

244 cause when we depleted CD8 T cells in B cell-deficient mice, these mice were unable to survive the in

245 tion of intestinal matriptase allowed Spint2-deficient mice to gain weight after birth and dramatical

246 , and transplanted with bone marrow from MPO-deficient mice to induce bone marrow MPO deletion (CKD-b

247 udy, host susceptibility of ASC inflammasome-deficient mice to R. australis was significantly greater

248 D88-, TRIF-, and alpha-galactosyltransferase-deficient mice to study B cell phenotypes and functional

249 We took advantage of strains of genetically deficient mice to study in vivo the role of innate immun

250 ved from adult male CCR3-proficient and CCR3-deficient mice to study the role of CCR3 in osteoclast f

251 e applied to wild-type (WT), TWEAK- and Fn14-deficient mice (TWEAK(-/-) and Fn14(-/-), respectively).

252 nt to CCHFV infection, and type I interferon-deficient mice typically develop a rapid-onset fatal dis

253 evelopment, we made osteoblast-specific SHP2 deficient mice using Osterix (Osx)-Cre as a driver to ex

254 3N2 IAV and IBV in AECIIs of Tmprss2/Tmprss4-deficient mice varied in sensitivity to protease inhibit

255 set that, upon adoptive transfer into B cell-deficient mice, was sufficient to promote EAE recovery.

256 Using ApoE-deficient or ApoE/CD163 double-deficient mice we aim to investigate the involvement of

257 In accordance, in Pogz deficient mice we find a significant upregulation of gen

258 Using cystathionine gamma-lyase (CSE)-deficient mice, we demonstrate an unexpected role of H(2

259 Using platelets from wild-type or Serca3-deficient mice, we demonstrated that an early (within 5-

260 Using CRBN-deficient mice, we further demonstrated that microvessal

261 Using Vbeta5-deficient mice, we show that these Vbeta5(+) iTreg cells

262 Using different NADPH oxidase-deficient mice, we show that TSPO is a key regulator of

263 th bone marrow from either wild-type or NGAL-deficient mice; we also transplanted irradiated MPO-immu

264 In parallel, we also found that DHA-deficient mice were characterized by an increased expres

265 On a high-fat diet, HDAC6-deficient mice were depleted in representatives of the S

266 Myeloid-specific, IL-33-deficient or ST2-deficient mice were employed to examine the role of IL-3

267 Aralar-deficient mice were fed a KD to investigate its therapeu

268 r in vivo studies revealed that myeloid-KLF6-deficient mice were highly resistant to endotoxin-induce

269 We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhi

270 ILC2s from autophagy-deficient mice were isolated to evaluate proliferation,

271 icating that the phenotypes observed in CD70-deficient mice were likely due to a lack of CD27 signali

272 Furthermore, DUSP11-deficient mice were more susceptible to LPS-induced endo

273 DAPK1-DD-deficient mice were more susceptible to tumor growth and

274 DC-deficient mice were predisposed to osteonecrosis followi

275 Functionally, TICAM2 deficient mice were protected from developing severe sys

276 Rad51ap1-deficient mice were protected from oncogene-driven spont

277 LRG1-deficient mice were resistant to diabetes-induced delay

278 In addition, TRPM7-deficient mice were resistant to T cell-driven hepatitis

279 Interestingly, CD8 T cells in B cell-deficient mice were skewed more toward effector phenotyp

280 Finally, we show that BTK-deficient mice were subject to severe experimental colit

281 ek-old male low-density-lipoprotein-receptor-deficient mice were subjected to 5/6 nephrectomy, irradi

282 Iron-replete and iron-deficient mice were treated weekly with testosterone pro

283 erent strains of cell-specific conditionally deficient mice were used to compare the role of myeloid-

284 At 4-6 months, CYP17A1-deficient mice were viable, with a KO:Het:WT ratio appro

285 T) release, were intact in endothelial MHC I-deficient mice, whereas complement depletion reduced bot

286 types of SERCAs, SERCA2b and SERCA3 (SERCA3 deficient mice), which may exert specific roles, yet ill

287 lycolytic responses were amplified in LXA(4)-deficient mice, which correlated with more severe pathol

288 A similar phenotype was observed in Ddr2-deficient mice, which exhibit dwarfism and defective bon

289 We generated LITAF-deficient mice, which exhibit marked resistance to letha

290 Siglec-G-deficient mice, which have increased numbers of B220(low

291 proximately 50% in the lungs of myeloid LKB1 deficient mice, which was not caused by increased cell d

292 ) stress was found in the livers of the CD36-deficient mice, while inhibited ER stress normalized the

293 d irradiated MPO-immunized MPO/IL-17A double-deficient mice with bone marrow from either IL-17A-defic

294 we transplanted irradiated MPO-immunized MPO-deficient mice with bone marrow from either wild-type or

295 ted the infection of C3H 5-lipoxygenase (LO)-deficient mice with Borrelia burgdorferi results in prol

296 Treatment of both wild-type and telomerase-deficient mice with telomerase gene therapy prevented th

297 Engraftment of mast cell-deficient mice with Tph1(-/-) mast cells or selective ma

298 Lsh-deficient mice without bone marrow transplantation exhib

299 laque burden in atheroprone apolipoprotein-E-deficient mice without compromising safety, and thereby

300 nflammation and fully phenocopied IL-6Ralpha-deficient mice without IL-6 overexpression.