ライフサイエンスコーパス: deficient mouse

1 ptozotocin-induced diabetic apolipoprotein E-deficient mouse).

2 genesis and vascular permeability in a DEP-1-deficient mouse.

3 embryonic retinoid metabolism using a Dhrs3-deficient mouse.

4 s to R294, which is mutated in the BXH2 IRF8-deficient mouse.

5 xifen-inducible cardiomyocyte-specific Runx1-deficient mouse.

6 nt on the neuromuscular junction in the ColQ deficient mouse, a model of end-plate acetylcholinestera

7 gels or ECM extracted from apolipoprotein E deficient mouse Achilles tendons were incubated with cat

8 BLM-deficient mouse and human cells suppress homeologous rec

9 coprecipitated with fibrinogen from FXIII-A-deficient mouse and human plasmas.

10 tes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cells, which showed a marked

11 trating lymphocytes was also reduced in LKB1-deficient mouse and human tumors.

12 Here, we describe a Fan1-deficient mouse and show that FAN1 is required for cellu

13 CS2 in behavior, we generated a novel SorCS2-deficient mouse, and identify a significant social memor

14 assessed muscle growth and repair in Anx A1-deficient mouse (AnxA1-/-).

15 xP3-, CD4-, CD8-, or CD25-depletion and gene-deficient mouse approaches, the authors demonstrated tha

16 Ralpha conferred tumorigenicity to Ink4a/Arf-deficient mouse astrocytes and human glioma cells in the

17 acologic inhibitors or its p47(phox) subunit deficient mouse BMDM also attenuated LPS-induced PGD(2),

18 n of patient-derived GNB1 variants in Cdkn2a-deficient mouse bone marrow followed by transplantation

19 nd PI3K signaling pathways are delayed in P2-deficient mouse bone marrow-derived macrophages, mouse e

20 o3 phosphorylation, and Tyro3-, Axl- and Mer-deficient mouse brain endothelial cells, we show that Ty

21 H]-LY450295 binding to stargazer and gamma-8-deficient mouse brain sections, demonstrates that TARPs

22 s transfected with GluN2B S1413L in GluN2A/B-deficient mouse brain slices revealed only partial rescu

23 on of the fraction of ciliated cells in Npc1-deficient mouse brains and the human fibroblasts of NPC1

24 human cells and cystathionine beta-synthase-deficient mouse brains, we find an acute and chronic inh

25 the CerS1 protein was not detected in CerS1-deficient mouse brains.

26 In contrast to carcinomas, BRCA1-deficient mouse carcinosarcomas resembling MBC show intr

27 unocytochemical analysis revealed that PAI-1-deficient mouse cardiac endothelial cells were more susc

28 Here, we generated caspase-1-deficient mouse (Casp1(Null)) on the C57BL/6 J backgroun

29 Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays

30 However, Ero1-deficient mouse cells still support oxidative protein fo

31 y protein changes within the nucleoli of Arf-deficient mouse cells.

32 ic resonance imaging and type I IFN receptor-deficient mouse chimeras, we demonstrate HSV-1 gains acc

33 The PPT1-deficient mouse (Cln1(-/-)) is a useful phenocopy of hum

34 In ADAM17-deficient mouse colonic epithelial (ADAM17(-/-) MCE) cel

35 The microbiota of MyD88- and TLR-deficient mouse colonies differed markedly, with each co

36 Thus, differences between TLR-deficient mouse colonies reflected long-term divergence

37 Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is es

38 natures in a muscle- and heart-specific CPT2-deficient mouse (Cpt2(M-/-)) model.

39 test our hypothesis: 1) the leptin receptor deficient mouse (dbdb) model of diabetic polyneuropathy

40 e production was TLR7 dependent because TLR7-deficient mouse DCs did not respond and TLR7 inhibitory

41 In TAP-deficient mouse dendritic cells, cross-presentation is e

42 Accordingly, p19(Arf)-deficient mouse embryo fibroblasts (MEFs) arrest in resp

43 a, lymphoma, and kidney tumor and that PCBP4-deficient mouse embryo fibroblasts (MEFs) exhibit enhanc

44 e C terminus repressed Hh signaling in Ptch1-deficient mouse embryo fibroblasts and that repression w

45 -type PS1 at equal gene dosage in presenilin-deficient mouse embryo fibroblasts resulted in trans-dom

46 uction of senescence is accelerated in Rrm2b deficient mouse embryo fibroblasts.

47 We found that Plp2-deficient mouse embryonic fibroblast and human fibroblas

48 ivity can be detected in two independent NCT-deficient mouse embryonic fibroblast lines and blocked b

49 p53 protein was increased in resting Mule-deficient mouse embryonic fibroblasts (MEFs) and embryon

50 Upon LPS stimulation, both rictor-deficient mouse embryonic fibroblasts (MEFs) and rictor

51 RelA-deficient mouse embryonic fibroblasts (MEFs) complemente

52 Moreover, PGAM5 deficient mouse embryonic fibroblasts (MEFs) exhibited d

53 At the cellular level, the Cdc14b-deficient mouse embryonic fibroblasts (MEFs) grew more s

54 MARCKS-deficient mouse embryonic fibroblasts (MEFs) responded t

55 sequently, we generated and rescued SKAP-Hom-deficient mouse embryonic fibroblasts (MEFs) with WT SKA

56 iological experiments using engineered Mcl-1 deficient mouse embryonic fibroblasts (MEFs, reliant onl

57 we used normal and eIF2alpha phosphorylation-deficient mouse embryonic fibroblasts and applied a micr

58 dria induced respiratory dysfunction in Mfn2-deficient mouse embryonic fibroblasts and cardiomyocytes

59 ed PHD2 protein levels were found in PSEN1/2-deficient mouse embryonic fibroblasts and in the cortex

60 DANGER-deficient mouse embryonic fibroblasts and neurons exhibi

61 mass spectrometric approach showed that ARH3-deficient mouse embryonic fibroblasts are characterized

62 Conversely, SIRT1-deficient mouse embryonic fibroblasts challenged with tu

63 Inhibitor kappaB kinase 2 (IKK2)-deficient mouse embryonic fibroblasts demonstrate abnorm

64 Similarly, experiments in cultured Oma1-deficient mouse embryonic fibroblasts link together impe

65 ath that can occur by apoptosis (in Bax, Bak-deficient mouse embryonic fibroblasts or HeLa cells) or

66 Using UGT1-deficient mouse embryonic fibroblasts reconstituted or n

67 Further investigation using TAK1-deficient mouse embryonic fibroblasts revealed that TNF-

68 Rb1-deficient mouse embryonic fibroblasts showed increased l

69 asts from laminopathy patients and lamin A/C-deficient mouse embryonic fibroblasts stably expressing

70 These functions are abrogated in lamin A/C-deficient mouse embryonic fibroblasts that recapitulate

71 -induced apoptosis in wild-type cells, c-Jun-deficient mouse embryonic fibroblasts were resistant to

72 entally relevant doses; however, in the Ku70-deficient mouse embryonic fibroblasts, exposure to a hig

73 n rescue the reprogramming potential of Tet2-deficient mouse embryonic fibroblasts.

74 expression, and chromatin structure of Ku70-deficient mouse embryonic fibroblasts.

75 he first time, the derivation of viable LIG3-deficient mouse embryonic fibroblasts.

76 NA double-strand breaks is impaired in RAP80-deficient mouse embryonic fibroblasts.

77 romosomes similar to those observed in MCPH1-deficient mouse embryonic fibroblasts.

78 own-like differentiation is increased in Id1-deficient mouse embryonic fibroblasts.

79 thynylbenzyl-dG with wild-type and pol kappa deficient mouse embryonic fibroblasts.

80 ion-specific antibodies in wild-type and Tdg-deficient mouse embryonic stem cells (ESCs).

81 Here we show that DNMT3L-deficient mouse embryonic stem cells (mESCs) exhibit dow

82 sely overlapping sites in wild-type and PRC2-deficient mouse embryonic stem cells (mESCs), demonstrat

83 ther show that polycomb repressive complex 2-deficient mouse embryonic stem cells also release Bmp4 b

84 differentiation capacity of heparan sulfate-deficient mouse embryonic stem cells and functioning in

85 performed a genome-wide RNAi screen in BRCA2-deficient mouse embryonic stem cells and validation in K

86 We show that Wt1-deficient mouse embryonic stem cells exhibit reduced hem

87 or occupancy in wild-type or DNA methylation-deficient mouse embryonic stem cells following HDAC inhi

88 mRtel1-deficient mouse embryonic stem cells showed sensitivity

89 Therefore we used mRtel1-deficient mouse embryonic stem cells to examine the func

90 rests cardiac differentiation, whereas Hoxb1-deficient mouse embryos display premature cardiac differ

91 Placentas from Grhl2-deficient mouse embryos displayed defects in BCT cell po

92 Ryk-deficient mouse embryos displayed disrupted polarity of

93 Setd5-deficient mouse embryos exhibit severe defects in neural

94 Analysis of gut morphogenesis in Shroom3 deficient mouse embryos revealed that the direction of g

95 e inactivation, knockdown of nestin in agrin-deficient mouse embryos substantially restored AChR clus

96 indings suggest that excessive 5-HT in MAO-A-deficient mouse embryos triggers cellular signaling casc

97 Finally, in Irf6-deficient mouse embryos, Grhl3 expression in the perider

98 ing (ATAC-seq) of skin in wild-type and IRF6-deficient mouse embryos, we define the transcriptional p

99 cation of OPCs is severely affected in sulf1-deficient mouse embryos.

100 was significantly decreased in beta-catenin-deficient mouse endothelial cells, whereas its close hom

101 Using Dgcr8 and Dicer knockout (small RNA-deficient) mouse ES cells as the benchmark, we confirmed

102 High-resolution MRI of WT and Slitrk6-deficient mouse eyes revealed axial length increase in t

103 ompromised and fumarylacetoacetate hydrolase-deficient mouse (Fah-/-, Rag2-/-, Il2rg-/-, termed the F

104 Conversely, E2F1-deficient mouse fibroblasts had increased Ogt and Mgea5

105 ed vacuole phenotype observed in PI(3,5)P(2)-deficient mouse fibroblasts is suppressed by overexpress

106 periments with RIG-I-, MDA5-, and RIG-I/MDA5-deficient mouse fibroblasts showed that RIG-I is the cri

107 Galpha13-deficient mouse germinal centre B cells and human GCB-DL

108 berrant osteoblastic differentiation in Gli3-deficient mouse (Gli3(Xt-J/Xt-J)) and resulted in cranio

109 A proton-coupled folate transporter (PCFT)-deficient mouse has been previously described as a model

110 TRPC6-deficient mouse hearts 1 week after transverse aortic co

111 and stroke volume were blunted in dysferlin-deficient mouse hearts compared with that in wild-type h

112 Young dysferlin-deficient mouse hearts expressed normal isoforms of myof

113 SIRT6-deficient mouse hearts showed hyperactivation of IGF sig

114 ent PI3K signaling is up-regulated in klotho-deficient mouse hearts vs. wild-type hearts.

115 rst-stimulated long-term potentiation in Vav-deficient mouse hippocampal slices, suggesting that Vav-

116 ng 5-hydroxymethylcytosine formation in Tet2-deficient mouse HSPCs and suppresses human leukemic colo

117 migration and proliferation using a podocan-deficient mouse in combination with a model of arterial

118 fect is partially reversed in a calprotectin-deficient mouse, in which manganese is more readily avai

119 Wrb-deficient mouse inner hair cells (IHCs) displayed normal

120 eavage of GSDMD and caspases 3 and 7 in MLKL-deficient mouse intestines around embryonic day 18.

121 Unlike wild-type controls, germ-free Rab11a-deficient mouse intestines failed to tolerate the intral

122 The Necdin-deficient mouse is the only model that reproduces the re

123 In neprilysin-deficient mouse islets, angiotensin-(1-7) and neprilysin

124 to rescue the multi-cystic phenotype of Flcn-deficient mouse kidneys.

125 erlipidemic low-density lipoprotein receptor-deficient mouse (LDLR(-/-)) model, we induced plasma APN

126 e phenotypic characterization of a PI3Kgamma-deficient mouse line and found that PI3Kgamma-deficient

127 We generated a new Nlrc4-deficient mouse line and mice with S533D phosphomimetic

128 mouse lines, including a constitutive NEGR1-deficient mouse line as well as an ENU-mutagenised line

129 s neurological disease, we created a C9orf72-deficient mouse line.

130 We created a novel DBN deficient mouse line.

131 Experiments with conditionally AhR-deficient mouse lines identified keratinocytes as the pr

132 icits, we generated two neuronal progranulin-deficient mouse lines using CaMKII-Cre and Nestin-Cre.

133 s were also seen in multiple circadian clock-deficient mouse lines, our results therefore suggest tha

134 aled normal cone photoresponses in all RDH10-deficient mouse lines.

135 f Cyp1a2 and Cyp2e1 in WT, but not IRE1alpha-deficient mouse liver, indicating the essential role of

136 ssayed, i.e. in C57BL/6 wild type and VKORC1-deficient mouse liver, lung, and testis and rat liver, l

137 Furthermore, we found more apoptosis in Fak-deficient mouse livers compared to WT mouse livers after

138 Infected IL-8R2-deficient mouse lungs had higher expression of genes ass

139 intermediate-sized collagen fragments in FAP-deficient mouse lungs, consistent within vitrostudies sh

140 phorylation and downstream signaling in CD63-deficient mouse lungs.

141 herapeutically viable vulnerability of BRCA1-deficient mouse mammary cells that have acquired drug re

142 Human BRCA1 mutation carriers and BRCA1-deficient mouse mammary glands contain an abnormal popul

143 Our results suggest that the Pax7-deficient mouse may be a suitable model for investigatin

144 Our SNAP-25b-deficient mouse may represent a diabesity model.

145 The CCL2/CX3CR1 deficient mouse may thus serve as a model for age-relate

146 Analyses of SLC45A2- and OCA2-deficient mouse melanocytes show that SLC45A2 likely fun

147 s that can reverse microglial defects in Grn-deficient mouse microglia, we performed a compound scree

148 Finally, 10 independent HGprt-deficient mouse MN9D neuroblastoma lines showed no signs

149 Consistent with this, a cd93-deficient mouse model (in addition to apoe deficiency) d

150 By using a conditional Met-deficient mouse model (Met(flox/flox)), we show that Met

151 We generated a podocyte-specific sialylation-deficient mouse model (PCmas(-/-) ) by targeting CMP-Sia

152 mmation using a tamoxifen-inducible versican-deficient mouse model (Vcan(-/-) mice).

153 ogical function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to

154 ropenia in a glucose-6-phosphatase 3 (G6PC3)-deficient mouse model and in 2 rare diseases (GSD-Ib and

155 ilized a tamoxifen-inducible EC-specific YY1 deficient mouse model and showed that YY1 deletion in EC

156 genic mice were crossed with an LDL receptor-deficient mouse model and were fed a high-fat diet.

157 th behavioral characterization of the Chrna7 deficient mouse model appeared prudent.

158 In this study, we generated a CI-deficient mouse model by knockdown of the Ndufs6 gene us

159 y or 6 hours after DENV infection in a Stat1-deficient mouse model completely protected against or de

160 eover, studies with an HLA-transgenic, FVIII-deficient mouse model demonstrated that antibody product

161 Infusion of wild-type platelets into a TLR2-deficient mouse model established in vivo confirmation o

162 reviously, by using a radiation-induced Tp53-deficient mouse model for T-cell acute lymphoblastic lym

163 In this instance, the immune-deficient mouse model is unlikely to be appropriate for

164 The CD8(+) T cell-deficient mouse model may be useful for further investig

165 We generated a TSP-1-deficient mouse model of a partial hepatectomy (PH) and

166 ip has been investigated using a fibronectin-deficient mouse model of acute liver injury.

167 panying spontaneous HA deposition in the ank-deficient mouse model of arthritis.

168 s (in vitro), with an interleukin 10 (IL-10)-deficient mouse model of colon cancer that involves long

169 the development of heart defects in a Nipbl-deficient mouse model of Cornelia de Lange Syndrome, in

170 recently reported the generation of a Spint2-deficient mouse model of CTE.

171 and aggravated pathogenesis of a dystrophin-deficient mouse model of Duchenne muscular dystrophy.

172 oparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B.

173 ACDase activity (Farber disease) in the GALC-deficient mouse model of human GLD (twitcher) eliminates

174 After transplantation into an immune-deficient mouse model of human liver failure, iMPC-Heps

175 e T-cell infiltration in an established Pten-deficient mouse model of human prostate cancer.

176 We generated a conditional, fibronectin-deficient mouse model of liver injury and explored wheth

177 ributed to lethal pathology in an FcgammaR2b-deficient mouse model of lupus.

178 We developed a TREM-1/3-deficient mouse model of pneumonia and found that absenc

179 We used a MECP2 deficient mouse model of RTT as a strategy to obtain ins

180 Here, we report in a MECP2-deficient mouse model of RTT that the border of the cere

181 Notably, the periaxin-deficient mouse model of the neuropathy Charcot-Marie-To

182 tozotocin (STZ)-induced diabetes, an insulin-deficient mouse model of type 1 diabetes.

183 The inducible neuroplastin-deficient mouse model provides a new and unique means to

184 Studies in a TRPC6-deficient mouse model revealed an essential function of

185 Furthermore, inhibition of RANKL in a Brca1-deficient mouse model substantially curtailed mammary tu

186 Using a RECQL4-deficient mouse model that recapitulates skeletal abnorm

187 ating microRNA (miRNA) signature in a Smurf2-deficient mouse model that spontaneously develops diffus

188 Here, we report the generation of an Usp36-deficient mouse model to examine the function of this en

189 To address this question, we used a Pten-deficient mouse model to examine thyroid cells where a m

190 We used a T cell-specific RASA1-deficient mouse model to investigate the role of the p12

191 disease in Joubert syndrome, using a Cep290-deficient mouse model to recapitulate the phenotypic var

192 e correlation data to develop a myotubularin-deficient mouse model with a less severe phenotype than

193 In a chromosomal instable p53 deficient mouse model with accelerated lymphomagenesis,

194 In a MHC class I-deficient mouse model, all groups including the Ad5-ID93

195 reak) shows decreased virulence in an immune-deficient mouse model, compared with a strain from 1976.

196 d on the development of a constitutively pDC-deficient mouse model, highlights the pivotal role playe

197 In the HGprt-deficient mouse model, immunohistochemical stains for TH

198 In the folate-deficient mouse model, L-dopa resulted in a marked deple

199 Here we used a pericyte-deficient mouse model, Pdgfb(ret/ret), shown to have inc

200 al-transduced hematopoietic cells in the Mpl-deficient mouse model, we addressed whether known or pre

201 Using a Tnc-deficient mouse model, we present data that suggest an a

202 Using a novel Abcg4-deficient mouse model, we show that Abcg4 was able to ex

203 By generating a TC10-deficient mouse model, we show that despite reduced tota

204 e neuronal nitric oxide synthase (nNOS(-/-)) deficient mouse model, which displays slow transit in th

205 thod was validated using a novel plasmalogen-deficient mouse model, which lacks plasmanylethanolamine

206 le muscular dystrophy type 2C, with a Col6a2-deficient mouse model.

207 also restored normal sociability in a Shank3-deficient mouse model.

208 tors and ON-bipolar cells in a retinoschisin-deficient mouse model.

209 umors, which correspond to tumors in the Nf1-deficient mouse model.

210 chronic inflammation in a human-like Neu5Gc-deficient mouse model.

211 c deficiency of CXCR4 in an apolipoprotein E-deficient mouse model.

212 id cell (ILC) number and function in a Dock8-deficient mouse model.

213 ion molecule (SLAM)-associated protein (SAP)-deficient mouse model.

214 ss II and III PI3 kinases (PI3Ks) in an MTM1-deficient mouse model.

215 esis in the apolipoprotein E-deficient (ApoE-deficient) mouse model of atherosclerosis.

216 ied in serum from two independent dystrophin-deficient mouse models (mdx-Delta52 and mdx-23) were con

217 Phr1-deficient mouse models (Phr1(Delta8,9) and Phr1(Magellan

218 Here we characterize autophagy-deficient mouse models and provide in vivo evidence for

219 SCD1-deficient mouse models are protected against diet-induce

220 Because alpha-Gal A-deficient mouse models do not recapitulate cardiorenal f

221 e shown that cones degenerate in chromophore-deficient mouse models for Leber Congenital Amaurosis (L

222 Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission in utero, we

223 Similar to other CfH-deficient mouse models on nonautoimmune backgrounds, imm

224 -GP had a longer duration of effect in FVIII-deficient mouse models, approximately a twofold prolonge

225 Studies using eosinophil-deficient mouse models, including eosinophil-derived gra

226 In BRCA1-deficient mouse models, olaparib resistance predominantl

227 Here we show, using Cu-deficient mouse models, that steady-state levels of ATP7

228 Using apolipoprotein E-deficient mouse models, we demonstrated that preventing

229 Using transporter-deficient mouse models, we show here that sorafenib-gluc

230 nactivity in long-chain fatty acid oxidation-deficient mouse models.

231 revealed by the analysis of conditional Lrp1-deficient mouse models.

232 perinatal lethality in many of the signaling deficient mouse models.

233 diated gene therapy experiments in dysferlin-deficient mouse models.

234 complex 1(mTORC1) signaling pathway in Phr1-deficient mouse models.

235 apolipoprotein E-deficient, and LDL receptor-deficient mouse models.

236 , and cognitive levels in two different FMRP-deficient mouse models.

237 using mutant p53-R270H knockin and TAp63/p73-deficient mouse models.

238 r Kisspeptin-neurons, using Foxp2- and Sox14-deficient mouse models.

239 , we used constitutive and conditional TRPC3-deficient mouse models.

240 1 also prevented apoptosis in laminin-alpha2-deficient mouse muscle and primary human MDC1A myogenic

241 pha-catulin is reduced in alpha-dystrobrevin-deficient mouse muscle.

242 ff-target effects were excluded by using KOR-deficient mouse mutants.

243 tiation markers is ablated in both KIF1Bbeta-deficient mouse neuroblasts and human neuroblastomas tha

244 , LPS-induced cytokines from WT and elastase-deficient mouse neutrophils, as well as neutrophils of h

245 In a model of G6PC3-deficient mouse neutrophils, physiological concentration

246 fly rescue meiotic progression in cyclin B3-deficient mouse oocytes, indicating conservation of the

247 On the molecular level, PTPalpha-deficient mouse OPCs and rat CG4 cells have decreased Fy

248 ast, ADAM10 expression was normal on Tspan33-deficient mouse platelets in which Tspan14 is the major

249 rafts was impaired in factor XIII A subunit-deficient mouse platelets, which show impaired clot retr

250 lation of Syk and the FcRgamma chain in GPVI-deficient mouse platelets.

251 zed that the effects of insulin in autophagy-deficient mouse primary hepatocytes would be attenuated.

252 BRCA1-deficient mouse primary mammary epithelial cells show lo

253 observations, BRF1 overexpression in a Pten-deficient mouse (Pten(Delta/Delta) BRF1(Tg)) prostate ca

254 A2a-deficient mouse retina showed defective regulation of ph

255 Histological investigation of WT and Slitrk6-deficient mouse retinas in postnatal development indicat

256 ine in highly purified wild-type and Gtgamma-deficient mouse rod disc membranes.

257 y in individual intact wild-type and Gtgamma-deficient mouse rods was measured by single-cell suction

258 n proceed similarly in wild-type and Gtgamma-deficient mouse rods, but the complex formation between

259 t only IgM from PIV-vaccinated CD4(+) T cell-deficient mouse sera inhibited C. burnetii infection.

260 The PCFT-deficient mouse serves as a model for the hereditary fol

261 -stimulated B220(lo)CD138(+) cells from ELL2-deficient mouse spleens are 4-fold less abundant than fr

262 ascular endothelial cell (VEC)-specific Cx43-deficient mouse strain (VEC Cx43(-/-)) to produce double

263 this study, we generated a BP180 functional-deficient mouse strain by deleting its extracellular dom

264 study its physiological role, we used a gene-deficient mouse strain expressing the bacterial LacZ rep

265 orm-specific PI3K inhibitors and a PI3Kdelta-deficient mouse strain revealed that PI3Kalpha and PI3Kb

266 Here, we have created a new NKT-deficient mouse strain using transcription activator-lik

267 The new Traj18-deficient mouse strain will assist in studies of iNKT ce

268 l outcome of L. major infection in this gene-deficient mouse strain, we analyzed the monocytic compon

269 Taking advantage of a Ptk7-deficient mouse strain, we demonstrate that loss of Ptk7

270 In studies of a CD1d1-deficient mouse strain, we unexpectedly observed a sever

271 for this human pathogen utilizing the SIGIRR-deficient mouse strain, which exhibits significant intes

272 function of Themis2, we generated a Themis2-deficient mouse strain.

273 ing the acrosome reaction using a TPCN1 gene-deficient mouse strain.

274 R-Ras in DC functions, we generated a R-Ras-deficient mouse strain.

275 MC-deficient mouse strains and mice treated with the MC sta

276 ve characterization of different aged immune-deficient mouse strains revealed that T cells significan

277 We subjected 2 MC-deficient mouse strains to Pseudomonas aeruginosa skin w

278 Infections of Myd88- and TLR7-deficient mouse strains with RRV revealed that both Myd8

279 ion TCR from multiple MHC-sufficient and MHC-deficient mouse strains, and find that MHC-restricted an

280 ling pharmacological inhibitors, genetically deficient mouse strains, and global transcriptome analys

281 cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id

282 sted by studies in traditional KIT mutant MC-deficient mouse strains.

283 Previous work in the Aire-deficient mouse suggested a role for alpha-fodrin, a ubi

284 raft-versus-host disease (GVHD), wherein NIK-deficient mouse T cells transferred into MHC class II mi

285 ppaB activation and IL-2 production in MALT1-deficient mouse T cells.

286 cue IBNtxA analgesia in a mu-opioid receptor-deficient mouse that lacks all Oprm1 splice variants, ab

287 o the known chromosome 14 translocation, ATM-deficient mouse thymic lymphomas routinely contain a cen

288 he TC-NER pathway, is 10-fold reduced in TR4-deficient mouse tissues, and TR4 directly regulates CSB

289 t galectin-3 is broadly up-regulated in KLF3-deficient mouse tissues, that KLF3 occupies regulatory r

290 Using an MPYS-deficient mouse (Tmem173(<tm1Camb>)), we determined that

291 tore Dp71 expression in Muller cells of Dp71 deficient mouse to study molecular and functional effect

292 AMP1 fully rescues the phenotype of the GALC-deficient mouse (Twitcher), and widespread deletion of G

293 The Siglec-G-deficient mouse was also backcrossed to the autoimmune p

294 An Ormdl3-deficient mouse was generated and the role of ORMDL3 in

295 heart disease, whereas an additional kinase-deficient mouse was generated as a control.

296 Studying a newly established CCL22-deficient mouse, we demonstrate that CCL22 expression by

297 endothelial cells from an inducible PTP-PEST-deficient mouse, we found that PTP-PEST is not needed fo

298 Using an ME-deficient mouse, we show that ME is required for MLL-AF9

299 Finally, using a MATN-1-deficient mouse, we showed that angiogenesis during frac

300 RP-1/PARP-2-deficient mice by using a PARP-1-deficient mouse with a Cd4-promoter-driven deletion of P