ライフサイエンスコーパス: define

1 K2) in cancer progression have not been well defined.

2 of ZO-1 to cardiac physiology remains poorly defined.

3 sful mounting of T cell responses are poorly defined.

4 protection against influenza, have yet to be defined.

5 s coronary intervention (uLMS-PCI) is poorly defined.

6 , such as Alternaria alternata, is not fully defined.

7 ccelerated liver fibrosis have not been well defined.

8 nants of variability therefore remain poorly defined.

9 mpacted by enteric infections remains poorly defined.

10 of RSV disease in adults have not been well defined.

11 gal cell walls in CGD are still incompletely defined.

12 The precise etiology of CS is not fully defined.

13 ons (2, 3, and 4 consecutive d) were used to define 15 different heatwaves.

14 These findings define a connection between the reward and circadian pat

15 Thus, our findings define a mechanism essential for replisome assembly duri

16 Together, our findings define a metabolic mechanism regulated by astrocytic alp

17 These studies define a new role for Notch3 in manipulating the tumor m

18 In contrast, our data define a novel macrophage population that controls overw

19 We define a reverse greedy path and show both analytically

20 lls involves post-replicative gap repair and define a role for PrimPol in HR-mediated DNA damage tole

21 onal PCR- and immunohistochemical testing to define a sensitive ground truth of HP presence.

22 These results define a therapeutic window targeting the inflammatory p

23 nce genes (eg, beta-toxin, delta-toxin) that defined a pathogenic ecology.

24 Clinically meaningful changes were defined a priori and linear regression was used to model

25 ribosome profiling, demonstrating that CARP defines a comprehensive repertoire of targets.

26 MET exon 14 alteration defines a molecular subgroup of NSCLCs for which MET inh

27 Taken together this manuscript defines a novel role of E2F2 in cancer progression beyon

28 Our work also defines a region of the parameter space that is compatib

29 genome-wide association study approaches in defining a clear genotype to phenotype model.

30 ect poorly soluble natural products, thereby defining a form of contact-dependent, aquatic chemosensa

31 studies describing remission should clearly define all 3 components of remission.

32 ion, basic insight into the assembly of well-defined amphiphilic polymers to form functional structur

33 Our aim was to define an original workflow for the purification and sys

34 d lysosomal state is sustained over time and defines an adaptive homeostasis in the infected macropha

35 Our study defines an antifolate stress response in E. coli and lin

36 The 2H phosphoesterase motif defines an evolutionarily ancient protein domain present

37 1:2) conjugates (ARCs) that are structurally defined and easy to assemble.

38 regulating this complex process are not well defined and their understanding could offer potential ne

39 Defining and making room for the success of all partners

40 is an established analytical tool capable of defining and understanding complex tissues by determinin

41 Our findings define AP-1 as the key link between T cell activation an

42 to enable screening of new chemicals with a defined applicability domain and accuracy assessment.

43 st ubiquitin ligase subtype and reveal how a defined architecture within a disordered region contribu

44 t mouse model with carcinoma cells harboring defined ARHGAP35 alterations.

45 ation's collateral fitness effects, which we define as effects that do not derive from changes in the

46 CHD was defined as >=1 inpatient code or >=2 outpatient CHD diag

47 Treatment failure was defined as (1) any further surgical procedure related to

48 Favourable functional outcome was defined as a modified Rankin Scale score of 0-2 or a Gla

49 the ribose operon repressor, RbsR, was also defined as a pleiotropic regulator of flotation and viru

50 Persistent respiratory morbidity a priori defined as a respiratory PedsQL, a pediatric quality of

51 The cell cortex is typically defined as a thin layer of actin meshwork that uniformly

52 year preceding elicitation, and viraemia was defined as a viral load of 200 copies per mL or more.

53 Zero-day admissions, defined as admission and discharge within the same calen

54 Although conventionally defined as AG-rich motifs, recent genomic surveys reveal

55 were not associated with crash rate, whether defined as all crashes or at-fault crashes only (all p >

56 Twenty-one of 180 (12%) had HLH defined as an HLH probability >=70% according to histo s

57 Failure of SLT was defined as any further glaucoma procedure post-SLT or an

58 Acute choroidal ischemia, defined as any new choroidal ischemia clinically diagnos

59 MM was defined as at least 3 coexistent morbidities of high blo

60 Efficacy was defined as complete response (CR) rate on end-of-treatme

61 e time exception points were given, which we defined as conditional waitlist outcomes.

62 regression framework with a binary phenotype defined as event occurrence status during the follow-up

63 Three cohorts were defined as follows: 1) ICU survivors; 2) one-year surviv

64 Frailty was defined as having >=3 of the following 5 criteria from t

65 At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (comp

66 Success was defined as improvement in 3 Early Treatment Diabetic Ret

67 A chronic or resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexi

68 Conduction delay (CD) was defined as interelectrode conduction time of 7 to 11 ms

69 The cumulative failure of the AADI was defined as intraocular pressure (IOP) >18 mm Hg or not r

70 Refractory glaucoma was defined as IOP >21 mmHg on maximum tolerated glaucoma me

71 DAT deficit was defined as less than 65% of putamen striatal binding rat

72 SR was defined as modified thrombolysis in cerebral ischemia 2b

73 Long non-coding RNAs (lncRNAs) are defined as non-protein-coding transcripts that are at le

74 POAF was defined as occurrence of postcardiac surgery atrial fibr

75 Pulmonary dysfunction at discharge a priori defined as one of: mechanical ventilation, supplemental

76 n theory, an efficient retinal code could be defined as one that reduces redundancy to communicate as

77 lder groups combined) results, consensus was defined as outcomes scoring greater than 90% "critical"

78 Cases were defined as patients with at least a four-fold increase i

79 redictive value (PPV) occurred when iPET was defined as positive if the Deauville score was 4-5 (89%

80 Hypertension was defined as prescription of blood pressure-lowering drugs

81 The primary endpoint was time to recovery, defined as return to usual activities, with fever, heada

82 TC was defined as same-nodule histologic malignancy.

83 ly) and consisted mainly of acute reactions (defined as symptoms within 3 days of administration of i

84 posure and infection rather than competence, defined as the ability to transmit pathogens.

85 Metabolic flexibility was defined as the change in 24-h RQ from EBL during fasting

86 Incident visual loss was defined as the development of or worsening of visual los

87 The date of diagnosis was defined as the index date.

88 Noninferiority was defined as the lower limit of the 95% CI for the differe

89 MaxLCBI(4mm) was defined as the maximum LCBI within any 4-mm-long segment

90 s with circulatory shock (< 12 hr duration), defined as the need for vasopressors to maintain mean ar

91 Complexity, defined as the number of stable AF reentrant sites, was

92 A true-positive finding was defined as the presence of a pathology-confirmed cancer

93 The PPV was defined as the proportion of patients who had true-posit

94 mplementation, where the outcome variable is defined as the ratio of total sickness hours over the to

95 esponse with a 50 uV peak to peak amplitude, defined as the RMT, was evoked at the contralateral flex

96 The fidelity of quantum transport is defined as the transmission performance of an ensemble o

97 m variability during a particular period was defined as the variability in IOP measurements obtained

98 Super-responders were defined as those alive without HF hospitalization and wi

99 Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test.

100 n about how excitatory-inhibitory balance is defined at most synapses or about the mechanisms for est

101 glycan receptors using different techniques, define atomic-level structures of virus-glycan complexes

102 We also use this array of well-defined atomically thin MoSe(2) deposits to study possib

103 The sub-optimal responders were pre-defined based on different cut-offs for VA and central s

104 occurred among specific cell types that were defined based on their sensory and motor properties, pro

105 nderstand salinity distributions and compare defined bases of fresh water with salinity distributions

106 tabolism, providing an alternate molecularly defined biomarker for this drug.

107 ying step heights are displayed and shown to define both deformed and recovered structures.

108 These studies define BPIFB3 as a required host factor for both DENV an

109 Defined broadly, psychiatric epigenomics seeks to unders

110 anoids were grouped by biosynthetic pathway, defined by (1) the fatty acid precursor, including linol

111 Patients with osteoporosis defined by a clinical event, namely a fragility fracture

112 C enzyme then becomes autoacylated at a site defined by a conserved Asp-His-His-Cys motif.

113 nations of events predicting poor outcome as defined by a cumulative CCI >=37.1 at 90-days.

114 High-risk features were defined by bulky tumors, variant histology, lymphovascul

115 Response to lithium treatment was defined by continuous scores and categorical outcome (re

116 ssess the relative risk of the subpopulation defined by each rule compared to the total sample.

117 proving Pediatric Sepsis Outcomes Sepsis was defined by electronic health record evidence of suspecte

118 A higher inflammation subgroup was defined by elevations in a group of 7 markers in 36% of

119 nd CD11bCD33CD14CD15HLA-DR (monocytes), were defined by flow cytometry.

120 analyses by treatment or types of FLAIR-HAs defined by location (at proximal/distal middle cerebral

121 This response is defined by low levels of type I and III interferons juxt

122 s in genetic architecture between depression defined by minimal phenotyping and strictly defined majo

123 riprotein lipids located within the diameter defined by one SMALP.

124 Primary outcome was COPD defined by postbronchodilator ratio of forced expired vo

125 to result in a more effective ESD service as defined by process measures.

126 subpopulation of olfactory sensory neurons, defined by receptor expression, whose abundances were se

127 nd Dga1 are formed at discrete ER subdomains defined by seipin (Fld1), and a regulator of diacylglyce

128 Each vector was defined by structural (x-axis) and functional (y-axis) c

129 the incidence of high-grade adverse events, defined by the Common Terminology Criteria for Adverse E

130 -, and NDM-producing P. aeruginosa were well defined by the conventional mCIM and eCIM testing method

131 of 0-2, and were at high risk of disease as defined by the presence of an adverse-risk karyotype, th

132 secutive unexplained cases of NIHF that were defined by the presence of fetal ascites, pleural or per

133 As termination is defined by the release of product RNA from the transcrip

134 ary endpoint was abdominal pain response, as defined by the US Food and Drug Administration: at least

135 used to determine subgroups of participants defined by these features.

136 correcting these offsets is key to the well-defined calendar placement of a Middle Bronze Age tree-r

137 We aimed to define cell types in PB and to analyze their relationshi

138 tion as a unique tool for manipulating input-defined cell populations and mapping their outputs.

139 We, the WHO HIVResNet working group, defined central areas of future investigations to guide

140 ormance has not yet been validated in a well-defined cohort of patients with PG.

141 ntertwined and transient transcription waves defining competence in Streptococcus pneumoniae.

142 ia reduction of the sample volume under well-defined conditions.

143 ed molecules possessing interesting and well-defined conformational properties.

144 This study has shown that adopting defined core components of ESD is associated with provid

145 ssays to screen antiviral humoral responses, define correlates of immune protection, and down-select

146 nsequently, we generate a minimal chemically-defined culture medium in which IGF1 together with Activ

147 ion of confocal, super-resolution and EM, we defined DAT localization and its membrane diffusion para

148 the time to reach viral suppression below a defined detection threshold.

149 Sixty-nine patients with a 'clinically defined' diagnosis of FMD were genotyped for 18 single-n

150 Defining discontinuous antigenic epitopes remains a subs

151 ing diagnoses, drugs, and procedure codes to define diseases and procedures.

152 We define ecological responses as suitable habitat template

153 ictory results, such as whether CCL2 or IL12 define effective monocyte responses to the parasite.

154 However, genes that define electrophysiological properties in failing human

155 To better understand and define energy algorithms during physical activity as it

156 sent, histone marks are used to identify and define enhancers but do not consider the endogenous role

157 nodes and mucosal lymphoid tissues with well-defined entry and exit routes, the movement of leukocyte

158 Future studies should use standard, clearly defined exposure variables to strengthen understanding o

159 that population-weighted exposure to locally defined extreme heat (i.e., "population heat exposure")

160 en spatial distribution of biodiversity is a defining feature of nature.

161 On palpation, few ill-defined firm mobile masses were found in the upper outer

162 oolkit allows re-usable configurations to be defined for experiment metadata and local data collectio

163 many proteases, but this balance is not yet defined for some of the serine proteases that serve as c

164 These results will help to define future strategies for prophylaxis of bleeding in

165 ow temperatures, indicating that even a well-defined genetic or pharmacological manipulation may prod

166 ly controlled and efficient DSB formation at defined genomic sites and will be valuable tools to stud

167 viral tools, and molecular markers to better define GPe neuron subtypes.

168 Well-defined helical structures that have been identified in

169 hich it forms the superfamily Vombatoidea as defined here.

170 We defined HIV PrEP utilization as the number of people tak

171 engineered separation-of-function mutants to define how CENP-F contributes to kinetochore function.

172 e recognized by h5B3.1 has been structurally defined; however, the efficacy of h5B3.1 in vivo is unkn

173 Microarray and SPR assays of structurally defined HS oligosaccharides show that a rare 3-O-sulfati

174 lakes, pristine graphene flakes possess well-defined hydrophobic and hydrophilic regions: the basal p

175 framework characteristically requires a well-defined hypothetical intervention.

176 ing AION were included in the pcsAION cohort defined in 2 ways: AION within 2 months and AION within

177 GA on NIR/FAF images was defined in accordance to recently published Classificati

178 tions occupied by pulmonary macrophages were defined in nondiseased human lungs from smokers and nons

179 Although T cell migration is most frequently defined in the context of trafficking, analysis of speci

180 PrEP efficacy for covered sex acts, as defined in the HPTN 067/ADAPT protocol, was estimated us

181 sease-associated variants that remain poorly defined in their mechanism of action.

182 moderate, 15.0-29.9; and severe, >=30.0) and defined incident CKD (stage 3 or higher) as eGFR<60 ml/m

183 help to stratify patients at different risk, defining individual management plans, assessing criteria

184 ntrolled high-throughput preparation of well-defined interfaces containing polyatomic species ranging

185 Studies of model organisms defined intersecting signaling pathways that converge to

186 s of CKD-mineral and bone disorder have been defined, it is unknown if persistent phosphate wasting i

187 RPV6 and discuss how its structural elements define its unique functional properties.

188 Together, our findings define key components in HBV cccDNA formation.

189 ion of a completely amorphous region of well-defined length along a single silicon nanowire.

190 sed the SUV(max) and decreased the threshold-defined lesion volume.

191 mited predictive value of surface markers to define lineages, functions, or subpopulations.

192 In the current study, we defined "M1" macrophage and "M1"/"M2" ratio by transcrip

193 defined by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has

194 The discovery of CD4(+) T cell subset-defining master transcription factors and framing of the

195 lity with other conditions than for strictly defined MDD.

196 Moreover, the schemas have precisely defined measures of security against all adversaries, hu

197 known or suspected neuromodulatory activity, define mechanisms of signalling pathways from the gut mi

198 The aims of the present study were to define mechanisms of Treg subpopulation imbalance and id

199 G2, the insertion site is recognized through defined mechanisms, at least in members examined to date

200 Through incompletely defined mechanisms, CovR/S and RocA repress the expressi

201 (CT) is currently the standard technique to define minimal residual disease (MRD) status outside the

202 Our findings define molecular and temporal requirements of the nonpho

203 In addition, we have defined molecular responses to COVID-19 infection that a

204 re native lipid membranes assemble into well-defined multilayer structures, whereas diseased lipid me

205 Characterization of defined mutations in vitro identified defects in intrace

206 tivity is efficiently controlled within well-defined nanospaces.

207 the assembly of biomacromolecules into well-defined nanostructures, leveraging pathway complexity of

208 ill enable studies of how T cells respond to defined neoantigens in the context of peripheral toleran

209 Here, validated, defined neoantigens, predicted neoepitopes, and mutation

210 annotation of almost all transcriptomically defined neural cell types.

211 uses combinatorial assemblies of molecularly defined neuron populations for grouped-ensemble coding o

212 uggests that the protein secondary structure defines not only tertiary geometry, but also maintains c

213 he apnea-hypopnea index (events per hour) to define obstructive sleep apnea severity (normal, <5.0; m

214 nical endpoint of geographic atrophy (GA) as defined on color fundus photography (CFP).

215 identify transcription factors that define one subtype of neural crest, the cardiac crest, a

216 or intermediate duration, often in narrowly defined pain populations of patients who could tolerate

217 ential procedure for model specification via defining parameter values for a model.

218 itical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas sha

219 and reduces methodological heterogeneity in defining phenotype, obscuring biological heterogeneity i

220 e genome, translation must be inhibited at a defined point following infection to clear the template

221 wing the circadian properties of genetically defined populations of cells to be studied in real time.

222 yloidosis and glomerulonephropathies (GN) to define possible predictors for CVDEs.

223 ropose a set of patient characteristics that define potential candidates.

224 he ability to self-renew, differentiate into defined progenies and initiate the tumor growth.

225 entify promising prophylactic antibodies and define protective epitopes that can be used in rational

226 genous synaptic machinery immunostaining can define putative synaptic connections between neurons, as

227 f the pncA, rpsA and panD genes were used to define PZA resistance.

228 The RECIST-defined radiological response rate was lower than that f

229 lecular patterns (HAMPs); however, precisely defined receptors and elicitors associated with herbivor

230 Here, we evaluate the growth of genetically defined renal tumors and their association with patient

231 targeting in wild-type H9 cells to precisely define RFX6 expression and in parallel performed in situ

232 lied to disaggregate patients within RCTs to define risk-based variation in benefit, and an "effect-m

233 ired for biofilm formation, thus providing a defined role for this USP in mycobacterial physiology an

234 The well-defined Ru(II)-NHC-diamine complexes show unique structu

235 the representativeness of our data, and our defining sexually active women as those who have ever ha

236 of metallo-supramolecular systems with well-defined shapes and sizes in the range of 10-100 nm remai

237 ity among 12 regions comprising a previously defined spatial network were evaluated.

238 r analysis (MRA) have been widely adopted to define specific transcriptional perturbations from gene

239 es further therapeutic options for each BCLC-defined stage.

240 cyclopropanecarboxylate ligands to have well-defined sterically demanding catalysts capable of high l

241 We defined success as >=20% IOP reduction or >=1 medication

242 colleagues in this issue of Cancer Research define TAp63 and its downstream target miRNAs, miR-30c-2

243 ugh the generation and in vivo monitoring of defined TCR repertoires, we found that the immunodominan

244 Here, we define ten key challenges facing cancer immunotherapy, w

245 Using ciprofloxacin and ampicillin as well defined test cases, our work demonstrates that drug-targ

246 tor the kinetics of HIV-1 nuclear import and define the biochemical staging of these steps of infecti

247 solutions, however, it is important to first define the burden of disease.

248 g, and staged pharmacological inhibition, we define the cell behaviors underlying each stage of vascu

249 he visual system, these feedforward pathways define the classical feedforward receptive field (ffRF),

250 This paper aims to define the concepts of primary pseudotumor cerebri, in w

251 Transposon sequencing has been employed to define the core essential genome of this bacterium and g

252 ied hierarchical clustering to intrinsically define the functional boundaries of the MFC in all three

253 y, SWI/SNF chromatin remodeling was found to define the kinetics and selectivity of gene activation i

254 ansformations at the core of the events that define the morphological shape for C. jejuni as an intes

255 To define the natural history of NSE in an Irish cohort.

256 Thus, it is important to define the patient population that would now be consider

257 To define the physical basis for EapH1's inhibition of cath

258 ment, remodeling the epigenomic landscape to define the presumptive neural crest.

259 Our objective was to define the prevalence and correlates of abnormal pulmona

260 Heterogeneity characterization is crucial to define the quality of end products and to describe the e

261 These results define the repair pathways of DNA interstrand crosslinks

262 single-molecule force spectroscopy, we also define the response of the protein to mechanical force.

263 The purpose of this study was to define the risk of, and associations with, SAE and high-

264 Further research is needed to define the role of asymptomatic hyperuricaemia in these

265 Future work will define the role of pMRI in predicting kidney graft and p

266 First, we define the single-carrier and multicarrier mechanisms fo

267 diet for offspring vascular homeostasis and define the sperm and seminal plasma specific programming

268 amers binding DNA reveal the parameters that define the stability of p53/DNA complexes, and provide i

269 We define the structures of two unique species-specific com

270 characterization of CF sputum.Objectives: To define the transcriptional profile of sputum cells and i

271 To define the transcriptional profile of this airway immune

272 f the cellular FHL1 protein in CHIKV HVD and defined the biological significance of this interaction.

273 Our Fowler syndrome model therefore defined the pathobiology of this disease and provided ne

274 Furthermore, ER contact sites defined the position where PB and stress granule fission

275 ible chromatin in single cells by sequencing defined the transcription factor NFE2L2/NRF2 as a critic

276 double ring and an actomyosin ring-and also defines the essential roles of a RhoGEF-anillin module i

277 complex (ORC), a DNA replication initiator, defines the localization of the origins of replication i

278 This work defines the mammalian SKI complex as a broad-spectrum an

279 tive to the crossover site, which ultimately defines the pattern of chromosome segregation during mei

280 the last step of genetic flow and primarily defines the proteome.

281 ynamics of electron transfer, and frequently defines the success or failure of a transformation.

282 e complex at the head of the major knickzone defining the fluvial edge of the Tibetan Plateau, our fi

283 lecular weight metabolites are essential for defining the molecular phenotypes of cells.

284 This raises the question of defining the specific host and bacterial factors respons

285 ection process that are useful for precisely defining the start of each separation and quantifying th

286 tates or distort the Coulomb potentials that define them.

287 In this Perspective, we define these agents as 'proteomimetics' and discuss the

288 phogens that induce differentiation within a defined tissue geometry.

289 accine, the correlate of protection has been defined to be primarily antibody driven.

290 e and context-dependent functions of lineage-defining transcription factors in regulating specificati

291 NA-seq) data of gastric corpus epithelium to define transcriptomes of individual epithelial cells fro

292 Our findings define unique microbiome differences after chronic versu

293 TQC mechanisms have been defined using a limited panel of substrates that aberran

294 Menopausal status was defined using age as a proxy, whereby breast cancer case

295 AKI is defined using changes in creatinine from baseline.

296 hough optimal AA intake amounts remain to be defined, we strongly recommend that AA should be provide

297 Further work defining what number and which combination of risk varia

298 ular peripheral VF defects were measured and defined with a head-mounted display diagnostic algorithm

299 rdination complexes are often extremely well-defined, with errors in the positions on the order of 10

300 The sinonasal microbiome remains poorly defined, with our current knowledge based on a few cohor