ライフサイエンスコーパス: definitive

1 nctional status and quality of life were not definitive.

2 however, its role in prostate cancer is not definitive.

3 tually distinct and also distinct from their definitive accessions (Def), held by the testing authori

4 lly validated approach should lead to a more definitive, accurate picture of SDSL ESR experiments.

5 as defied efforts to derive reproducible and definitive anatomical maps of structural brain changes a

6 achieves stratified squamous epithelium from definitive and anterior foregut derived cultures.

7 herapies, heart transplantation (HTx) is the definitive and most effective therapy for an important p

8 emerging in alignment with the search for a definitive and trustworthy creatinine detection at the p

9 her experimental studies are needed to get a definitive answer to the question of the substrate selec

10 A definitive answer to this question has remained elusive

11 st exciting questions in ecology and provide definitive answers.

12 the time of Ss diagnosis and 6 months after definitive anthelmintic treatment.

13 am data, and a nonrandomized design limiting definitive ascertainment of the robustness of a PrEP-ded

14 The definitive assessment of progression-free survival was d

15 Although no definitive association between HPgV infection and diseas

16 Infected tissues also show definitive bands at ~1280, 1234, and 1201 cm(-1) charact

17 s evidence for establishing these fossils as definitive bilaterians but also has implications for the

18 g the use of chiral asymmetry by itself as a definitive biosignature.

19 ss of interventions to improve acceptance of definitive care among people screened.

20 However, to date, there are no definitive causal genes identified for isolated BA in hu

21 th S. haematobium as a group 1 carcinogen, a definitive cause of cancer.

22 rize the pathophysiology and to identify the definitive causes.

23 there are no strategies that replicate these definitive characteristics of bone tissue.

24 from studies published to date preclude any definitive characterization of the relationship between

25 All patients were treated with definitive chemoradiation (median dose 50.4 Gy) followed

26 Methods: In total, 49 patients receiving definitive chemoradiation for locally advanced HNSCCs un

27 nts in cervical cancer patients treated with definitive chemoradiation.

28 ort study aimed to assess survival following definitive chemoradiotherapy (DCR) with or without salva

29 the potential organ-preservation strategy of definitive chemoradiotherapy as a primary treatment for

30 Using novel diagnostic algorithms, definitive chronic pancreatitis can be diagnosed by imag

31 No definitive clinical guidelines derived from randomized c

32 technology that need to be reviewed for its definitive clinical translation.

33 ntific regulation may increase the number of definitive clinical trials in nephrology and improve the

34 This study sought to generate a definitive comparative effectiveness model of these ther

35 e in mammalian cells, have failed to reach a definitive conclusion about their function.

36 er, imprecision in study results precludes a definitive conclusion, and further research is needed to

37 reparation, although we cannot overreach any definitive conclusion.

38 odels of tauopathy make it difficult to draw definitive conclusions about the biological role of tau

39 Drawing definitive conclusions about the origin of most Paleoarc

40 This study is underpowered, which limits definitive conclusions about the use of MP, as an altern

41 whether the extant literature justifies any definitive conclusions about whether and how SITBs may b

42 More studies are needed to reach definitive conclusions about whether SITBs are associate

43 While more research is needed for definitive conclusions and their application in medical

44 ted outcome measures are needed to draw more definitive conclusions on transplant outcomes and organ

45 This paucity of data does not allow for definitive conclusions to be drawn regarding saliva as a

46 ing post hoc nature of the analyses preclude definitive conclusions.

47 red to support these findings and reach more definitive conclusions.

48 eria for statistical superiority, precluding definitive conclusions.

49 1% (95% CI, 69% to 88%) after treatment with definitive concurrent chemoradiotherapy (CRT) after IC a

50 e patients, but it may not be sufficient for definitive confirmation of cardiovascular disease suspec

51 et it has remained challenging to identify a definitive connection between aggregation and pathogenic

52 high remission rates and can bridge to more definitive consolidation therapy with curative intent.

53 However, no definitive correlation between the functional potency an

54 but are dispensable for the formation of the definitive cortex.

55 Cost data did not indicate a definitive cost savings of either treatment method ($562

56 ents who achieve a favorable response to IC, definitive CRT results in improved survival compared wit

57 t receive urate-lowering therapy, which is a definitive, curative treatment, and fewer than a half of

58 urgical options providing the possibility of definitive cure in patients presenting with early-stage

59 s remain barriers to prolonged remission and definitive cure.

60 emory and other forms of cognition, although definitive data are hard to come by.

61 ce and new Mtb infections-outcomes for which definitive data are unavailable.

62 t for patients with influenza infection, but definitive data do not exist.

63 t expected to support action potentials, but definitive data were lacking.

64 and therapeutic potential of exosomes, but a definitive description of these extracellular vesicles r

65 Though the developed models are not a definitive descriptor of O2 carrier interaction in tumor

66 There was no difference in time to definitive deterioration of global HRQOL (median, 31.8 m

67 and followed up for 6-12 months to establish definitive diagnoses.

68 We included only cases for which a definitive diagnosis (histologic diagnosis or >=1 year s

69 ion warrants early surgical consultation for definitive diagnosis and management.

70 number variants, respectively, resulted in a definitive diagnosis in 68 of 277 samples, with variabil

71 Next-generation sequencing provides a definitive diagnosis in 80-90% of patients.

72 The definitive diagnosis is made by electron microscopy with

73 s an adjunct to blood cultures when making a definitive diagnosis of candidemia.

74 However, definitive diagnosis of CAPA is challenging.

75 en whole-exome sequencing (WES) provided the definitive diagnosis of congenital chloride diarrhea in

76 A definitive diagnosis of DILI is, nowadays, one of the ma

77 alization, comorbid conditions, suspected or definitive diagnosis of infection, microbial analyses).

78 Definitive diagnosis of intracranial tumors relies on ti

79 useful as a test of cure in CSF and for the definitive diagnosis of NCC in plasma.

80 The current reference standard to make a definitive diagnosis of SARS-CoV-2 infection is the reve

81 n and propose a diagnostic workup to reach a definitive diagnosis, on which treatment is heavily depe

82 have historically advised thyroidectomy for definitive diagnosis.

83 n to treat the patient empirically without a definitive diagnosis.

84 y clinical syndrome in domestic dogs with no definitive diagnostic tests, which causes marked morbidi

85 al sheet(2,3) and later morphogenesis of the definitive digestive and respiratory organs(4-6) have be

86 nd in particular psychiatric illnesses, lack definitive disease-altering therapeutics.

87 There are currently no definitive disease-modifying therapies for traumatic bra

88 ubstantial morbidity and mortality and lacks definitive disease-modifying therapy.

89 ntinuous telemetric ECG monitoring and had a definitive disposition of hospital discharge or death.

90 s with COVID-19 at Mount Sinai Hospital with definitive dispositions, 140 patients had telemetric mon

91 series of inductive interactions between the definitive endoderm (DE) and the surrounding splanchnic

92 begin with the differentiation of hPSCs into definitive endoderm (DE) using activin A, followed by th

93 The definitive endoderm and hepatic endoderm cells were char

94 Otherwise, lower Wnt signals lead to definitive endoderm and higher Wnt signals induce presom

95 c stem cells and embryonic stem cell-derived definitive endoderm cells, screening 7905 distinct DNA s

96 Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic ta

97 We also show that overexpression of two definitive endoderm transcription factors, T and Foxa2,

98 g embryonic and extra-embryonic mesoderm and definitive endoderm.

99 e developmental ontology of the limb bud, or definitive endoderm.

100 A definitive energy algorithm was observed as a reflection

101 ronavirus 2 (SARS-CoV-2) and death; however, definitive epidemiological evidence is lacking.

102 ssessment, imaging, and NT-proBNP may not be definitive, especially in HFpEF.

103 Definitive etiological links exist between mutations in

104 nority of ASD cases are determined to have a definitive etiology and the pathogenesis of most ASD is

105 2, CALM3, TRDN) were found to have strong or definitive evidence for causality in LQTS with atypical

106 te numerous efforts since, there has been no definitive evidence for eclipse generated gravity waves

107 modulate striatal dopamine (DA) release, but definitive evidence for GABA receptors on DA axons is la

108 This suggests challenges for detecting definitive evidence for life, both in the simulated lacu

109 The definitive evidence for the presence of metaphosphates,

110 Definitive evidence is lacking as to whether the same pr

111 ent coronavirus disease 2019 (Covid-19), but definitive evidence is lacking.

112 of BTKi's in COVID-19 are needed to provide definitive evidence of benefit.

113 this study include that associations are not definitive evidence of causation and that potential effe

114 Definitive evidence of causation will require a randomiz

115 e most advanced, having already demonstrated definitive evidence of clinical benefits in cancer and i

116 ural, and molecular cardiac series showed no definitive evidence of direct myocardial infection.

117 g a part of routine clinical management, but definitive evidence of its cost-effectiveness in rheumat

118 We found no definitive evidence of SARS-CoV-2 in kidney cells.

119 of S stercoralis infection, but there is no definitive evidence on the optimal dose.

120 Mossbauer spectroscopy provides definitive evidence that 1alpha and 1beta generate oxoir

121 There is no definitive evidence that aerosol generated by energy dev

122 There is no definitive evidence that changes in physical activity/se

123 Sequential sampling provides definitive evidence that DNA damage response clones outc

124 Our study provides definitive evidence that genetic alterations of SUGP1 ge

125 Our studies thus provide definitive evidence that ISL1 is a critical player in th

126 It details the first definitive evidence that selective optogenetic stimulati

127 This work provides definitive evidence that translation strongly affects mR

128 No definitive evidence, either from pes-on-manus overprinti

129 The low Cu content alloys are definitive examples of glasses that exhibit first-order

130 inimal amounts of misfolded prions providing definitive experimental evidence that dogs are resistant

131 -of-origin for these tumors, despite lack of definitive experimental evidence.

132 lysis of the heterochiral complex provides a definitive explanation for the nonlinear behaviour of th

133 There is no definitive explanation for this stability due to the lim

134 s (MNPs) and T cells, but whether these have definitive features of tissue residence (long-term reten

135 the transmission of Toxoplasma gondii to the definitive feline host via predation, and this relations

136 To provide a more definitive figure for Ras mutation frequency in cancer,

137 Although a widespread phenomenon, definitive functions for endogenous targeted mRNAs and t

138 genes (KCNQ1, KCNH2, SCN5A) were curated as definitive genes for typical LQTS.

139 e modeled human MYL4 mutants, one of the few definitive genetic causes of AF.

140 Together, these data provide definitive genetic evidence for the critical role of the

141 ombencephalosynapsis has no previously known definitive genetic or environmental causes.

142 stage, but polysomnography still remains the definitive gold standard.

143 eptance and use of this tool is the need for definitive guidance on test design parameters, such as t

144 Definitive haematopoiesis in the fetal liver supports se

145 Embryonic definitive hematopoiesis generates hematopoietic stem an

146 demonstrated that ginger treatment promoted definitive hematopoiesis via Bmp signaling.

147 , where they expand and differentiate during definitive hematopoiesis.

148 vascular mesodermal progenitors (HVMPs) with definitive hematopoietic potential produce the highest n

149 e defective telomere maintenance and reduced definitive hematopoietic potential, to understand the ef

150 Definitive hematopoietic stem and progenitor cells (HSPC

151 thin the yolk sac and fetal liver as well as definitive hematopoietic stem cells located within the b

152 rting cardiac, and cerebral perfusion before definitive hemostasis.

153 ch involves two different hosts: a mammalian definitive host and a molluscan intermediate host.

154 cular determinants that identify cats as the definitive host for T. gondii are unknown.

155 Additionally, in the gut of its definitive host, felines, Toxoplasma converts into gamet

156 (mosquito) intermediate hosts and mammalian definitive hosts for their propagation.

157 both within blood-feeding mosquitoes, their definitive hosts, and in vertebrates, which are intermed

158 y confirmed that ungulates are almost always definitive hosts, and we discuss the exceptional cases w

159 re they occasionally intermediate instead of definitive hosts, as in taeniid cestodes?

160 After the definitive identification against the authentic standard

161 ce spectroscopy, which can achieves the most definitive identification but lacks throughput.

162 Such enhanced ability to advance from definitive identification of single to multiple site-spe

163 nd the delay involved in performing culture, definitive identification, and susceptibility testing of

164 HiFSA sequencing yields definitive identity and purity information concurrently,

165 of future molecular studies that may be more definitive in fixing the number of RGC types in rabbit r

166 tween fibrosis and carcinogenesis seems less definitive in patients with NASH as a sizeable proportio

167 accharides in numerous biological processes, definitive information on the bioactive sequences of the

168 features suggestive of PCV, which may prompt definitive investigations such as ICGA.

169 and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques.

170 xpression and is predictive of relapse after definitive local therapy in both discovery and validatio

171 ng the Phoenix criteria for BCR, after other definitive local treatments, and with advanced metastati

172 with curative intent and received IC before definitive locoregional therapy.

173 revealed timely tumor drainage and afforded definitive lymph node visualization upon its administrat

174 ur phylogenetic analysis, acquisition of the definitive mammalian middle ear in allotherians such as

175 Here we report a definitive mammalian middle ear preserved in an eobaatar

176 sents the initial morphological stage of the definitive mammalian middle ear.

177 e therapy [topical medications (n = 363)] or definitive management (n = 342) that included mucous mem

178 ion of the molecule CD69 is widely used as a definitive marker for T(RM), yet it is unclear whether C

179 ndary electron background that has precluded definitive measurements of the low-energy electrons emit

180 Delaying definitive mechanical mitral valve replacement and the c

181 of the few fossil myxomycetes, and the only definitive Mesozoic one.

182 ystal X-ray diffraction is arguably the most definitive method for molecular structure determination,

183 ifferent clinical features, and conduct more definitive microbial analyses using metagenomic shotgun

184 iate-mass main-sequence stars, which enables definitive mode identification.

185 A definitive molecular diagnosis was made in 8/12 probands

186 carbapenems, and piperacillin-tazobactam as definitive monotherapy.

187 A definitive multicenter study is now warranted in this po

188 Our analysis presents the most definitive mutational landscape of mitochondrial genomes

189 HCM genes, only 8 (24%) were categorized as definitive ( MYBPC3, MYH7, TNNT2, TNNI3, TPM1, ACTC1, MY

190 There is no definitive neural marker of suicidal thoughts and behavi

191 Sample size estimates for definitive neuroprotective trials ranged from 142 to 366

192 i were defined, which were modified into the definitive nuclear configuration through the metamorphic

193 generated by three commonly used strategies-definitive-null, targeted knockout (KO)-first, and CRISP

194 n years old, DNH 152 represents the earliest definitive occurrence of Paranthropus robustus, and DNH

195 to CSF FTA-ABS in studies with patients with definitive or presumptive neurosyphilis.

196 d require larger randomized trials with more definitive outcome measures.

197 body MRI were performed every 12 weeks until definitive PD was evident with one or both modalities.

198 These data provide definitive physiological evidence that aberrant integrat

199 overview of the drawbacks that impede their definitive point-of-care establishment.

200 relimb initiation gene Tbx5 and instruct the definitive position of the forelimb.

201 ate from Wolffian ducts and migrate to their definitive position.

202 situ hybridization for SARS-CoV-2 showed no definitive positivity.

203 A definitive pre-mortem diagnosis of prion disease depends

204 Here, we present definitive preclinical studies enabling a first-in-human

205 Definitive predictive biomarkers and targets to overcome

206 In the absence of zygotic paf1 function, definitive premigratory NC progenitors arise but fail to

207 The early clinical trials justified the more definitive preventive trials of the 1980s and beyond.

208 brolizumab intravenously every 3 weeks until definitive progression or unacceptable toxicity.

209 ients with CM (1.7%) converted to ISM and no definitive progression to advanced SM was found.

210 Although definitive proof of efficacy awaits an appropriately pow

211 Readers who wish to access the definitive published version of this manuscript and any

212 idation study that included 99 patients with definitive PVN transplanted post January 1, 2009 and fol

213 ts suspected of relapse of lung cancer after definitive radiotherapy (conventional fractionated radio

214 two (13%) patients were referred for primary definitive radiotherapy, 51% (88/172) for prostate-speci

215 Regarding definitive recommendations based on poor neurologic prog

216 No definitive recommendations could be made about the natur

217 Given the overall low certainty of evidence, definitive recommendations will need confirmation in add

218 clinical trial has been performed to provide definitive recommendations, the authors of the studies i

219 on of PVH-OT neurons, we performed the first definitive recording of OT neurons in awake mice using t

220 eurons into a few major classes, followed by definitive refinement, creating subclasses upon settling

221 en preoperatively (T(pre) ) and 1 year after definitive restoration (T(2) ).

222 No definitive restorative therapies exist that target these

223 t settings and often take a week to obtain a definitive result.

224 While 15 to 23 STR loci normally give definitive results in simple kinship testing, additional

225 as low sensitivity and takes days to produce definitive results.

226 The purpose of this concise definitive review is to familiarize the reader with The

227 rate recognition by endoribonuclease toxins, definitive RNA target identification requires toxin expr

228 flammatory and autoimmune conditions, but no definitive role in pathogenesis has been established.

229 he effect of myristoylated Akt, suggesting a definitive role of PRAS40 phosphorylation in mTORC1 acti

230 Experimental data was generated by Definitive-Screening-Design, followed by model developme

231 As a definitive signature of this state, we find a quasi-one-

232 At present, no definitive solution exists for the challenge of treating

233 te has a tendency to form clusters, while no definitive statement about clustering or avoidance of Fe

234 sions were distinguished from their official definitive stock.

235 Genes were categorized as having definitive, strong, moderate, limited, or no evidence of

236 hanisms have been illuminated importantly by definitive structural and biochemical analysis of their

237 light on the function and evolution of this definitive structure.

238 Few definitive studies addressed the role of specific subuni

239 es, acute neurologic injury, and burns, more definitive studies are needed, including acute coronary

240 be carried out on a single device, allowing definitive studies of the relationship between gate-cont

241 ificant clinical progress has been made, yet definitive studies underpinning mechanisms of entry, inf

242 Although the definitive substance or substances contributing to injur

243 N0M0 esophageal adenocarcinoma who underwent definitive surgery (2004-2015) and had characteristics c

244 after IC and 54% (95% CI, 44% to 61%) after definitive surgery and postoperative radiotherapy or CRT

245 ved survival compared with those who undergo definitive surgery.

246 per day oral talazoparib (1 mg), followed by definitive surgery.

247 t after acute necrotizing mid-body necrosis, definitive surgical management with distal pancreatectom

248 kely to undergo organ preservation and avoid definitive surgical resection at 5years (67% vs 30%; P =

249 that encouraging private providers to order definitive TB diagnostic tests earlier during patient co

250 tion are often non-specific, and there is no definitive test for the accurate diagnosis of infection.

251 d tests consistently, and poor conversion to definitive testing.

252 However, a definitive therapeutic target remains to be identified i

253 le of induction chemotherapy (IC) in guiding definitive therapy in patients with SNUC.

254 Conversely, definitive therapy provided significant benefit by impro

255 gulatory cytokines that normalized following definitive therapy.

256 ould be sought at an early stage to initiate definitive therapy.

257 9 patients (3%) with durable FICS undergoing definitive total hip arthroplasty surgery because of loc

258 ence is found in up to 40% of men with prior definitive (total prostatectomy or whole-prostate radiat

259 candidates (30 patients) and restaging after definitive treatment (167 patients).

260 analysis showed a difference in the risk of definitive treatment failure (oral group vs. intravenous

261 The primary end point was definitive treatment failure within 1 year after randomi

262 Similarly, surgical resection is also the definitive treatment for biliary tract cancers, and live

263 ype tenosynovial giant cell tumours is not a definitive treatment for every patient because it involv

264 The major obstacle to more-definitive treatment for HIV infection is the early esta

265 Operative repair is the definitive treatment for incisional ventral hernias but

266 ib and bevacizumab versus niraparib alone as definitive treatment for platinum-sensitive recurrent ov

267 ifying the exact cause of HLH is crucial, as definitive treatment for primary disease is hematopoieti

268 of hyperfunctional parathyroid gland is the definitive treatment for primary hyperparathyroidism (pH

269 tigation of different therapeutic options, a definitive treatment has not been developed for this deb

270 s meropenem remains the preferred choice for definitive treatment of ceftriaxone non-susceptible E. c

271 Definitive treatment of hepatobiliary malignancies inclu

272 ogen-deprivation therapy (ADT) is a standard definitive treatment of localized prostate cancer (LPCa)

273 carbapenems, and piperacillin-tazobactam as definitive treatment of P. aeruginosa bacteremia.

274 In addition, definitive treatment of S. stercoralis infection resulte

275 tanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but curre

276 More definitive treatment trials will be needed to identify o

277 idism (PHPT) is a common endocrine disorder, definitive treatment usually requiring surgical removal

278 +/- SD, 71.5 +/- 7.2) with BCR after primary definitive treatment with prostatectomy (n = 42) or radi

279 the management of Graves' disease and early definitive treatment with radioiodine should be offered

280 Active surveillance was defined as no definitive treatment within the first year of diagnosis

281 CI, 9.2% to 13.9%); P < .001); of receipt of definitive treatment, 54.8% vs 41.4% (difference, 13.4%

282 teria are needed to ensure prompt diagnosis, definitive treatment, and improved outcomes for children

283 ulative incidence of disease progression and definitive treatment, but not metastasis or prostate can

284 Progression to at least intermediate-risk, definitive treatment, metastasis, prostate cancer-specif

285 ge-to recovery, to a more durable bridge, to definitive treatment, or to decision.

286 care of patients with SCID from diagnosis to definitive treatment, reduce disease burden, and ultimat

287 duals up to 60 years of age, and there is no definitive treatment.

288 nosis (CAD) systems for PCa detection before definitive treatment.

289 Liver transplant is the only definitive treatment.

290 Delivery is the only definitive treatment.

291 r, these mechanisms often indicate specific, definitive treatments.

292 lation thus demanding for more effective and definitive treatments.

293 A definitive trial is warranted.

294 pilot study serves as evidence to continue a definitive trial.

295 (AFL) settings, in preparation for a future definitive trial.

296 cificities and co-factors can support a more definitive understanding of cellular mechanisms in physi

297 While a definitive understanding of schizophrenia etiology is fa

298 ll adenocarcinomas eventually developed into definitive uterine carcinosarcomas with carcinomatous an

299 st CT may be of assistance when results from definitive viral testing are delayed.

300 Our goal was to test this idea in a more definitive way using genetic knock out mice.