ライフサイエンスコーパス: deformability

1 direct readout (sensing DNA conformation and deformability).

2 an fully account for the observed changes in deformability.

3 lamina, the main structure limiting nuclear deformability.

4 l enable us to assess nuclear elasticity and deformability.

5 o have significant protective effects on RBC deformability.

6 to impaired functionality including loss of deformability.

7 the purpose of improving their strength and deformability.

8 ble Open Reading frame) exert changes on GIE deformability.

9 hod can hence be reliably used to assess RBC deformability.

10 ug resistance produces a similar increase in deformability.

11 ttribute related to the functional erythroid deformability.

12 es not always provide a meaningful proxy for deformability.

13 mechanical phenotyping based on single-cell deformability.

14 rticles to microgels with a desired size and deformability.

15 ut muscular phenotypes did not alter nuclear deformability.

16 frequent morphologic abnormalities and lower deformability.

17 te the effect of nuclear shape in whole cell deformability.

18 e invasion but does not with respect to cell deformability.

19 , increased osmotic fragility, and decreased deformability.

20 RBC aggregation and adhesion, and decreased deformability.

21 s exhibited more swelling due to higher cell deformability.

22 he separation distance, irrespective of cell deformability.

23 single parasite-exported protein on host RBC deformability.

24 lls based on differences in size, shape, and deformability.

25 mal alterations in nuclear shape and nuclear deformability.

26 the shock-induced decrease in red blood cell deformability.

27 n participate in sliding-filament reversible deformability.

28 ciated with significantly decreased cellular deformability.

29 these complications if they alter blood cell deformability.

30 ndex is a marker of decreased red blood cell deformability.

31 event gut injury and preserve red blood cell deformability.

32 uced intestinal injury, lung injury, and RBC deformability.

33 ped in the matrix because of limited nuclear deformability.

34 en level-dependent changes in red blood cell deformability.

35 y, matrix deformability, cell size, and cell deformability.

36 terogeneous morphology changes and decreased deformability.

37 e inner ear fluids, and membranous labyrinth deformability.

38 l to establish normal membrane stability and deformability.

39 s challenging as they often lack mobility or deformability.

40 ite, and schizont stage) due to their varied deformability.

41 racy of 87.8% (electrical impedance), 70.1% (deformability), 42.7% (relaxation index) and 93.3% (comb

42 The sensor relies on differentiating the RBC deformability (a mechanical biomarker) that is highly co

43 ironments and often requires a high cellular deformability, a property limited by the cell nucleus.

44 sed membrane mechanical stability, decreased deformability, abnormal morphology, and spontaneous vesi

45 ehaviour and gains superior malleability and deformability against pulverization.

46 High degrees of mechanical deformability allow intimate contact with biological tis

47 h muscular diseases caused increased nuclear deformability, almost all mutations tested had defects i

48 This nuclear deformability altered in response to actin, myosin, form

49 ted HL-60 cells, which may also impact their deformability; although lamin A is typically down-regula

50 l types (MDA-MB-436 and MCF-7) with distinct deformabilities and metastatic potentials, and (ii) a he

51 (sRBC) biomechanics, including pathological deformability and adhesion, correlate with clinical seve

52 collapse is intimately linked to the unique deformability and affinity of PLPs for fibrin fibres, as

53 ed on the potential role of altered red cell deformability and blood rheology in precipitating vaso-o

54 Deformability and cell orientation indices were recorded

55 a combination of high strength, substantial deformability and ductility, large elastic limit and low

56 governed by the combination of RBC membrane deformability and dynamics of adhesion bonds.

57 ttention is paid to ways in which mechanical deformability and electronic performance can coexist.

58 itus (T2DM) are associated with reduced cell deformability and elevated blood viscosity, which contri

59 soft bodies are not only impressive in their deformability and flexibility but can also be potentiall

60 bited significant decreases in both membrane deformability and flickering.

61 cellular mechanobiology-such as immune cell deformability and force generation-to impact functions s

62 could lead to significant alterations to RBC deformability and increase clearance of both infected an

63 thereby gain insight into DNA conformation, deformability and interactions in different sequence and

64 ss-of-function kinase screen for cancer cell deformability and invasive potential in a high-throughpu

65 of multiple-input control and the resulting deformability and maneuverability.

66 eparation platform, flexible cells with high deformability and metastatic propensity flowed out, whil

67 ggests that cellular properties such as cell deformability and microvillus elasticity actively modula

68 t of the storage on the erythrocyte membrane deformability and morphology.

69 tatic cells, suggests that cells with higher deformability and motility are likely selected during ex

70 ds on a physicochemical balance between cell deformability and physical tissue constraints.

71 Rheologic parameters of erythrocyte deformability and plasma viscosity were measured.

72 Such deposition could limit RBC deformability and promote the production of nitric oxide

73 Mature gametocytes exhibit increased deformability and reappear in the peripheral circulation

74 93.3% (combination of electrical impedance, deformability and relaxation index) with high sensitivit

75 lohexane ring of Ox, leading to this reduced deformability and resultant decrease in HMGB1a's binding

76 Our results suggest that neglecting cell deformability and rolling velocity may significantly ove

77 We then address the effect of cell deformability and rolling velocity on the flow resistanc

78 ng maturation, midstage gametocytes show low deformability and sequester in the bone marrow and splee

79 Here, we characterized for the first time deformability and size changes in CD34+ cells, and expel

80 Cellular plasma membrane deformability and stability is important in a range of b

81 Membrane deformability and stability of primitive erythroblasts,

82 desirable combination of homogeneous plastic deformability and strength in the bcc MPEA MoNbTi, enabl

83 Our computational results on the cell deformability and tank-treading frequency are compared w

84 of such swelling was indicative of the cell deformability and the cytoskeleton mechanics.

85 new method for the in situ study of nuclear deformability and the mechanical coupling between the ce

86 which the infected RBCs gradually lose their deformability and their ability to recover their origina

87 sensors that autonomously regulate their own deformability and thereby flow velocity through capillar

88 parum (Pf-RBCs) parasite lose their membrane deformability and they also exhibit enhanced cytoadheren

89 an important role in the regulation of cell deformability and tumor suppression.

90 y (size, shape, and composition), mechanics (deformability), and motility (chemotaxis and migration)

91 exhibiting mutual strengthening, compatible deformability, and a linearly dependent relationship bet

92 , tensile biaxial deformation, and real-time deformability, and cell traction was measured using two-

93 p between tumor-initiating capacity and cell deformability, and demonstrate that tumor-initiating cel

94 ration, increased osmotic fragility, reduced deformability, and heterogeneity in osmotic ektacytometr

95 ber of partners, they ensure cell integrity, deformability, and migration.

96 y red blood cell aggregation, red blood cell deformability, and plasma viscosity.

97 RBC tissue trapping, deformability, and RBC aggregation and adhesion were stu

98 Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in

99 g-stage cultures at 41 degrees C reduced RBC deformability, and this effect correlated strongly with

100 n when alterations in their size, shape, and deformability are detected.

101 g high sensitivity with excellent mechanical deformability arising from the inherent property of the

102 microporous barriers is regulated by nuclear deformability as controlled by lamin-A and -B, and (ii)

103 ransmigration in vitro are determined by TRC deformability, as a result of low Cdc42 and high Sox2.

104 soluble actin, resulting in altered membrane deformability, as determined by alterations in RBC trans

105 Deformability, as determined by comparing passage times

106 RBC deformability assayed at a physiological shear stress de

107 ysis of stored blood showed reduction in RBC deformability at 7 days of storage, reflecting a five-fo

108 antly decreased visualized and laser-derived deformability at any given shear stress >=1 Pa.

109 ic technology capable of probing single-cell deformability at approximately 2,000 cells/s.

110 Deformability at the system level is enabled using rigid

111 amazing stiffness, toughness, strength, and deformability attributed to the reconfigurable 3D networ

112 Furthermore, histones impair erythrocyte deformability based on reduced passage of erythrocytes t

113 material has been devoted to increasing its deformability beyond flexibility-a characteristic posses

114 T/HS decreases lung injury and improves RBC deformability but exerts a limited protective effect on

115 ties, suggesting that not only the increased deformability but reduced friction may be a factor in en

116 To understand the regulation of nuclear deformability by these active forces, we created differe

117 nical properties, we either decrease nuclear deformability by twofold overexpression of the nuclear p

118 found that a mathematical description of DNA-deformability, called V(step), could be used to distingu

119 th the solid inclusion, the observed loss of deformability can be predicted quantitatively using the

120 Subtle changes in red blood cell (RBC) deformability, caused by infection or drug treatment, co

121 e in turn depends on matrix porosity, matrix deformability, cell size, and cell deformability.

122 Moreover, nuclear shape, mechanics, and deformability change with differentiation state and have

123 All three methods detect cell deformability changes induced by exposure to altered osm

124 dielectric properties of the cells and their deformability characteristics that affect HDLF.

125 that the CR1-dependent increase in membrane deformability could be relevant for facilitating the tra

126 ell mechanical phenotype: constriction-based deformability cytometry (cDC), shear flow deformability

127 creening of cell mechanotype is microfluidic deformability cytometry (mDC), in which the apparent def

128 Here, we introduce quantitative deformability cytometry (q-DC), a method for rapid, cali

129 s at days 11, 14, 18 and 21, using Real-Time Deformability Cytometry (RT-DC) and Atomic Force Microsc

130 We introduce real-time deformability cytometry (RT-DC) for continuous cell mech

131 ed deformability cytometry (cDC), shear flow deformability cytometry (sDC) and extensional flow defor

132 ability cytometry (sDC) and extensional flow deformability cytometry (xDC).

133 Here, using real-time deformability cytometry and flicker spectroscopy to defi

134 Microfluidic deformability cytometry brings the statistical accuracy

135 Performing real-time deformability cytometry experiments on both model sphere

136 anding of the applicability of the different deformability cytometry methods and provides context for

137 A new method, real-time deformability cytometry, probes cell stiffness at high t

138 idic microcirculation mimetic, and real-time deformability cytometry.

139 y profoundly higher deformation in real-time deformability cytometry.

140 ion result in unexpected relationships among deformability, density, and volume.

141 th Y-27632 (Rho-kinase inhibitor to increase deformability), diamide (cell-stiffening agent), cilosta

142 oth time points in the PDL + T/HS group, but deformability did not return to T/SS levels.

143 The largest deformability difference observed for cells from VGP and

144 sly alter fusion kinetics, although membrane deformability does.

145 d its memory, genome integrity, and cellular deformability during migration, our results highlight th

146 isms underlying reduced red blood cell (RBC) deformability during Plasmodium falciparum (Pf) malaria

147 parameters, such as cell size, density, and deformability, during cellular processes have been inves

148 lectrodes to simultaneously characterize the deformability, electrical impedance and relaxation index

149 ial microfluidic constrictions, during which deformability, electrical impedance and relaxation index

150 MSC deformability evaluated using filtration through polycar

151 eratin-free cells show about 60% higher cell deformability even for small deformations.

152 During rotation, duct deformability extends the frequency bandwidth and enhanc

153 ts practical strength is low and its elastic deformability extremely limited.

154 nvestigate numerically the importance of RBC deformability for merozoite alignment.

155 Despite the critical importance of fibrin deformability for outcomes of bleeding and thrombosis, t

156 strict or permit membrane fusion by changing deformability, for instance, using interferon-induced pr

157 RBCs with reduced surface area and cellular deformability has long been recognized as contributing t

158 hromatin modifications contribute to nuclear deformability has not been defined.

159 ng red blood cells (RBCs) in size, shape and deformability have extended circulation times and altere

160 cal stimulus known to drastically alter cell deformability (i.e., prior shear exposure (PSE) to 100 P

161 res of the nucleus including shape, size and deformability impact its function affecting normal cellu

162 Here, we use cell deformability in both shear-dominant and inertia-dominan

163 s are heterogeneous in terms of adhesion and deformability in flow.

164 profound size effect in enhancing plastic co-deformability in nanoscale metal-ceramic multilayers.

165 In this study, improving RBC deformability in older adults restored deoxygenation-ind

166 rginine and nitric oxide (NO) pathway on RBC deformability in Pf-infected patients and parasite cultu

167 nd for understanding the physical origins of deformability in soft matter.

168 ation methods, and that a switch in cellular deformability in the transition from immature to mature

169 ir strain to failure, and efforts to improve deformability in these materials are usually found to be

170 nvestigate the role of red blood cells (RBC) deformability in type 2 diabetes mellitus (T2DM) without

171 Human red blood cells (RBCs) deformability in vitro was assessed during iron dextran

172 The influence of red blood cell (RBC) deformability in whole blood on platelet margination is

173 -induced ATP release, whereas decreasing RBC deformability in young adults reduced ATP release to the

174 creased HSC stiffness and increased physical deformability, in part by dephosphorylating Spetin1 (Tyr

175 However, a dose-dependent deformability increase upon latrunculin B-induced actin

176 In both cases, nuclear deformability increases with time, scaling as a power la

177 ffected sRBC biomechanics by decreasing sRBC deformability, increasing sRBC occlusion under normoxic

178 measured by digital video microscopy, and a Deformability index (DI) calculated.

179 We propose a combinatory deformability indicator (Xi) to prescreen candidate bulk

180 Despite their deformability, intraarterially delivered MSCs entrap at

181 Our findings suggest that tumor cell deformability is a key factor in controlling extravasati

182 We conclude that decreased RBC deformability is a primary contributor to age-related im

183 nstrate that the age-related decrease in RBC deformability is a primary mechanism of impaired deoxyge

184 he impact of beta-AR signaling on macrophage deformability is dependent on actin-related proteins 2/3

185 The cell deformability is measured by evaluating the transit time

186 We also show that the effect of RESA on deformability is more pronounced at febrile temperature,

187 Moreover, we show that GIE deformability is regulated by protein kinase A (PKA)-med

188 rochemical performance and robust mechanical deformability; its electrochemical characteristics can b

189 attery achieves significant linear and areal deformability, large twistability and bendability.

190 erized by altered cellular contractility and deformability, lending them the flexibility to dissemina

191 suspension and in a non-contact manner, the deformability levels of breast cancer cells with differe

192 Such fatigue-induced deformability loss is more pronounced at higher amplitud

193 However, in vitro deformability measurements have not been directly linked

194 d provides context for the interpretation of deformability measurements performed using different pla

195 in mapping, electron microscopy, and dynamic deformability measurements, we investigated the mechanis

196 's passage time is expected to depend on its deformability, measurements from existing approaches are

197 The deformability of a cell is the direct result of a comple

198 he effect of length scales on the plastic co-deformability of a metal and a ceramic.

199 age of the high compliance and large elastic deformability of a soft polymer gel to directly measure

200 Surprisingly, the deformability of ACBP is greater than that observed for

201 more promising approaches for improving the deformability of amorphous metals that usually exhibit m

202 nsistency between macroscopic plasticity and deformability of an amorphous alloy.

203 Deformability of blood cells is known to influence vascu

204 ogenous L-arginine to the cultures increased deformability of both Pf-free and trophozoite-harboring

205 electroporation with flow cytometry to study deformability of cells at the single-cell level with a t

206 er a constriction, which is dominated by the deformability of cells, and the transit time required fo

207 ing of DNA dictates recognition by PurR, and deformability of DNA along the A-B continuum is importan

208 Such a device is also used to probe the deformability of elastic capsules and viscoelastic biolo

209 niques have been introduced that exploit the deformability of elastomeric materials like polydimethyl

210 20 and waixenicin A block the changes in the deformability of erythrocytes and inhibit merozoite inva

211 Increased aggregation and decreased deformability of erythrocytes are associated with HIV-in

212 EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin

213 Since the deformability of grains plays an important role in macro

214 und that RESA plays a major role in reducing deformability of host cells at the early ring stage of p

215 We apply this technique to compare the deformability of human myeloid and lymphoid leukemia cel

216 We also noted that ethanol can reverse the deformability of impaired RBCs.

217 Here, we report the superplastic deformability of indium selenide (InSe).

218 ugh beta-adrenoceptors (beta-AR) reduces the deformability of macrophages; this is dependent on chang

219 estration of immature GIEs and that regained deformability of mature gametocytes is associated with t

220 The deformability of MCF-7 breast cancer cells was character

221 Results reveal low, medium, and large deformability of melanoma cells originating from vertica

222 ht on practical advances in promoting cyclic deformability of metallic nanomaterials.

223 ons, particularly thiocyanate, increased the deformability of microgels during drying.

224 Using this approach we rapidly assay the deformability of native populations of leukocytes and ma

225 .0001; standardised mixed model) between the deformability of nucleated and enucleated cells, while t

226 There is a growing recognition that the deformability of particles used for drug delivery plays

227 hanisms responsible for the dramatic loss of deformability of Pf-infected RBCs have remained elusive.

228 speed atomic force microscopy to analyse the deformability of PIEZO1 under force in membranes on a mi

229 Deformability of Plasmodium falciparum gametocyte-infect

230 Our results further indicate that loss of deformability of RBCs during cyclic deformation is much

231 l shear exposure-paradoxically increases the deformability of RBCs when examined under low-shear cond

232 transported to the host spectrin network, on deformability of ring-stage parasite-harboring human RBC

233 -terminal zinc fingers recognize the extreme deformability of SSBs and drive co-operative, stepwise s

234 e was attributed to the increased mechanical deformability of the 1,5-regioisomer as compared to the

235 Changing the deformability of the cell by perturbing its cytoskeleton

236 The mechanical stability and deformability of the cell nucleus are crucial to many bi

237 molecular availability that accounts for the deformability of the cell surface and the balance of for

238 rocesses depend critically on the mechanical deformability of the cytoplasm.

239 of assemblies were largely determined by the deformability of the effective nanoparticles (that is, n

240 is dependent upon both the polarity and the deformability of the electron density within the metal-s

241 oach, we show that stevor expression impacts deformability of the erythrocyte membrane.

242 The reduced deformability of the HGPS nuclear lamina possibly could

243 The remarkable deformability of the human red blood cell (RBC) results

244 We uncover deformability of the ligand capping layer that leads to

245 hermal-mechanical coupling that exploits the deformability of the LM inclusions to create thermally c

246 show that purposefully engineering a larger deformability of the microchannel, by changing the geome

247 Decreasing the overall deformability of the microvilli greatly reduces a simula

248 suggest that during cell transmigration the deformability of the nucleus could be a limiting factor,

249 ese layers with the AFM tip leads to greater deformability of the surface with decreasing applied loa

250 However, deformability of the tertiary structure, as manifested b

251 ovary cells and find significantly increased deformability of the transformed cells.

252 interplay between the temperature-dependent deformability of the vesicles and the DNA-mediated adhes

253 Here, we investigate the deformability of three colorectal cancer (CRC) cell line

254 ntrinsic values, and the sequence-dependent "deformability" of a given dimer.

255 The influence of RBC deformability on collisions between RBCs and platelets w

256 or unparasitized erythrocytes with decreased deformability or rosettes is also a key interaction betw

257 Microfluidics can be used to measure cell deformability over a wide range of flow conditions, oper

258 nogen (P = 0.015), and decreased erythrocyte deformability (P < 0.001).

259 on the equation of state (EoS)-related tidal deformability parameter Lambda, but at late times is als

260 together impair NO production and reduce RBC deformability, particularly at febrile temperature.

261 tivity, topological constraints, and vesicle deformability produces a myriad of dynamical states.

262 sly shown to mediate an increase in membrane deformability promoted by CR1 ligation.

263 occurring during RBC storage focusing on RBC deformability, RBC-dependent vasoregulatory function, an

264 ocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, le

265 Y-27632 improved RBC deformability (RCTT: 8.228 +/- 0.083) and ATP release (1

266 /- 17.2%) in older and diamide decreased RBC deformability (RCTT: 8.955 +/- 0.114) and ATP release (6

267 ethanol co-administration using microfluidic deformability screening.

268 itemia as a testing sample, the microfluidic deformability sensor achieved an excellent sensitivity (

269 throughput and label-free microfluidic cell deformability sensor for quantitative parasitemia measur

270 roscopy and flow cytometry, the microfluidic deformability sensor would possibly allow for label-free

271 donor-specific variations in dose dependent deformability shift were revealed below 500 mug/mL iron

272 A/C in human epithelial cells and measured a deformability similar to that of adult hematopoietic ste

273 althy red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as s

274 e hypothesis that age-related changes in RBC deformability (Study 1) and cAMP signalling (Study 2) co

275 roperties, including charge, polarizability, deformability, surface charge mobility, dielectric featu

276 vasive breast cancer cells exhibited greater deformability than weakly-invasive breast cancer cells.

277 s accompanied by an increase in RBC membrane deformability that positively correlates with the number

278 cell assays show reduced ring-stage Pf-RBCs deformability, the parameters influencing their microcir

279 The protein responds to DNA shape and deformability-the stiff, naturally straight double-helic

280 hese can be used to learn about neutron star deformability through observations of the moment of iner

281 orary understanding ascribes the loss of RBC deformability to a 10-fold increase in membrane stiffnes

282 g future energy-storage devices with desired deformability together with high performance.

283 Mechanical deformability underpins many of the advantages of organi

284 ow metallic bicrystals with endurable cyclic deformability via GB migration.

285 ecorated RBC (n = 6) displayed limited their deformability (vs six controls, p < 0.05) in two-dimensi

286 RBC deformability was also lower in older vs. young as indic

287 In vivo RBC deformability was better preserved by blood plus albumin

288 Red blood cell deformability was measured by a laser-assisted ektacytom

289 RBC membrane deformability was measured using 2-dimensional microchan

290 To assess RBC injury, RBC deformability was measured, as the RBC elongation index

291 nt response to ethanol administration on RBC deformability was noted using our biomimetic microfluidi

292 Erythrocyte deformability was observed at various fluid shear stress

293 RBC deformability was reduced during the acute attack (day0)

294 The cell deformability was then compared with that of a trapped p

295 a tool for biological research, we show the deformability we measure is an early biomarker for pluri

296 Based on physical differences of size and deformability, we explore micro-ellipse filters consisti

297 ; elastomers with high cross-linking and low deformability were required for polarization.

298 T/HS-induced impairments in RBC deformability were significantly reduced at both time po

299 rmeation through aquaporin-1 mediates the EV deformability, which further supports EV transport in hy

300 Deformability while remaining viable is an important mec