ライフサイエンスコーパス: degeneration

1 epithelium), and H35.50 (unspecified macular degeneration).

2 diabetic retinopathy and age-related macular degeneration.

3 sion of disease and further alpha-motoneuron degeneration.

4 tracellular space prior to catastrophic axon degeneration.

5 r diseases including keratoconus and macular degeneration.

6 for developing treatment strategies for disc degeneration.

7 utopsy-confirmed AD and frontotemporal lobar degeneration.

8 by damage to the nervous system and retinal degeneration.

9 trophic lateral sclerosis and frontotemporal degeneration.

10 ntents to the extracellular space to promote degeneration.

11 by retinal ganglion cell (RGC) death and ON degeneration.

12 cell death, including in hereditary retinal degeneration.

13 necroptosis, MLKL does not directly trigger degeneration.

14 veloped progressive and severe outer retinal degeneration.

15 RP families were more likely to have retinal degeneration.

16 dent mitochondrial fragmentation and neurite degeneration.

17 ctor spinae and multifidus muscle lipomatous degeneration.

18 riability in mutant PRPH2-associated retinal degeneration.

19 o both improve vision and slow photoreceptor degeneration.

20 l (RGC) axon dysfunction that precedes frank degeneration.

21 H transcription factor necessary for tapetum degeneration.

22 ent mitochondrial fragmentation and neuronal degeneration.

23 of the neuroretina form before complete eye degeneration.

24 ded for patients who are at risk for macular degeneration.

25 omarker of active axonal injury and neuronal degeneration.

26 ior to structural changes of RPE and retinal degeneration.

27 disease with very subtle dopaminergic neuron degeneration.

28 ination and metabolic adaptation to neuronal degeneration.

29 e metabolism prior to detectable optic nerve degeneration.

30 erity in patients with USH2A-related retinal degeneration.

31 ctor spinae and multifidus muscle lipomatous degeneration.

32 ected cell types in diseases such as macular degeneration.

33 lastase) under pressure to induce aneurysmal degeneration.

34 GMP/PKG signaling-induced ER stress and cone degeneration.

35 apoptosis, that are activated during retinal degeneration.

36 els in Prcd-KO retina prior to photoreceptor degeneration.

37 e susceptible to light-induced photoreceptor degeneration.

38 ranging from rod dysfunction to rod and cone degeneration.

39 s may act in concert to further accelerate Y degeneration.

40 vity, which leads to calcium influx and axon degeneration.

41 treatment of bone disease and ageing-related degeneration.

42 probably by progressive central white matter degeneration.

43 diagnostics directed at age-related macular degeneration.

44 han that for other diseases, such as macular degeneration.

45 and 2 eyes (2.8%) developed cystoid macular degeneration.

46 lasmic reticulum (ER) stress-associated cone degeneration.

47 l function in patients with regional retinal degeneration.

48 n the RPE cells during aging and age-related degeneration.

49 ticularly vulnerable tissue to age-dependent degeneration.

50 emic syndrome (aHUS) and age-related macular degeneration.

51 ctivation of SARM1 and thereby led to axonal degeneration.

52 ier (BBB) function and accelerates cognitive degeneration.

53 se with hepatic steatosis, inflammation, and degeneration.

54 omozygous mice exhibited progressive retinal degeneration.

55 nating both groups from frontotemporal lobar degeneration.

56 eir contribution to neuronal dysfunction and degeneration.

57 rmal retinal morphology, without evidence of degeneration.

58 multiple sclerosis is linked to neuroaxonal degeneration.

59 is a widespread mechanism of programmed axon degeneration.

60 ve retinal cones in a mouse model of retinal degeneration.

61 ere investigated during ongoing motoneuronal degeneration.

62 S) is a fatal disease involving motor neuron degeneration.

63 d anxiety in patients with inherited retinal degenerations.

64 r successful gene therapy in certain retinal degenerations.

65 valuation of patients with inherited retinal degenerations.

66 ommon models used to study RP is the retinal degeneration-10 (rd10) mouse, which has a mutation in Ph

67 ct costs associated with age-related macular degeneration ($17 379.41-$657 406.55).

68 ortuosity (2.5%), retinal pigment epithelium degeneration (2.5%), myelinated nerve fiber layer (1.3%)

69 nduce pathways that are implicated in neural degeneration(3-9).

70 etGC-activating proteins (GCAPs) and retinal degeneration-3 protein (RD3).

71 ortion of patients with frontotemporal lobar degeneration (~45%) exhibit TDP-43 positive neuronal inc

72 ities (26.6% versus 7.3%), exudative macular degeneration (5.2% versus 0.1%), and geographic atrophy

73 Intervertebral disc (IVD) degeneration activates the differentiation of prehypertr

74 h of young men because of progressive muscle degeneration aggravated by sterile inflammation.

75 deposits associated with age-related macular degeneration, Alzheimer's disease, and many other age-re

76 ars with GA secondary to age-related macular degeneration (AMD) and best-corrected visual acuity (BCV

77 d with increased risk of age-related macular degeneration (AMD) and disease progression, but the prec

78 iety among subjects with age-related macular degeneration (AMD) and its association with AMD in a lar

79 with the development of age-related macular degeneration (AMD) and other complementopathies.

80 tion models for advanced age-related macular degeneration (AMD) are based on a restrictive set of ris

81 s with large drusen from age-related macular degeneration (AMD) before and after the drusen spontaneo

82 y be secondary to active age-related macular degeneration (AMD) disease progression in both eyes.

83 spring of parent(s) with age-related macular degeneration (AMD) have a 45% lifetime risk of developin

84 Age-related macular degeneration (AMD) is a chronic eye condition that leads

85 treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the

86 Age-related macular degeneration (AMD) is the leading cause of legal blindne

87 cated in the etiology of age-related macular degeneration (AMD), a major cause of blindness in the el

88 r comorbidity other than age-related macular degeneration (AMD), diabetic retinopathy, glaucoma, or c

89 s to the pathogenesis of age-related macular degeneration (AMD), the role of retinal perfusion is unc

90 of age or later, showed age-related macular degeneration (AMD)-like fundus changes.

91 raded centrally for late age-related macular degeneration (AMD).

92 cell classes affected by age-related macular degeneration (AMD).

93 (GA) onset secondary to age-related macular degeneration (AMD).

94 than in individuals with age-related macular degeneration (AMD).

95 riodontal disease(PD) to age-related macular degeneration (AMD).

96 reast cancers as well as age-related macular degeneration (AMD).

97 development to advanced age-related macular degeneration (AMD).

98 ) with nicotinamide riboside slowed the axon degeneration and demyelination, although it did not alte

99 ases characterized primarily by motor neuron degeneration and distal weakness.

100 s were associated with hepatocyte ballooning degeneration and ductular reaction.

101 ] exhibited rapid, early-onset photoreceptor degeneration and functional decline characterized by str

102 lC-2 function lead to retinal and testicular degeneration and leukodystrophy, whereas gain-of-functio

103 Mutant UQCRC1 expression leads to neurite degeneration and mitochondrial respiratory chain dysfunc

104 or understanding the pathogenesis of macular degeneration and other related degenerative disorders, a

105 ales have distinct relationships between IVD degeneration and pain using an in vivo rat model.

106 n the BR-mediated regulation of tapetal cell degeneration and pollen development in Solanum lycopersi

107 mplex DNA templates being prone to diversity degeneration and provides a way to preserve the quality

108 l muscle disorder characterized by cycles of degeneration and regeneration of multinucleated myofiber

109 This process causes rapid Y/W degeneration and simultaneous evolution of dosage compen

110 ignaling represent a key mechanism in aortic degeneration and that targeting STING may prevent sporad

111 the molecular mechanisms underlying neuronal degeneration and the heterogeneity of the patient popula

112 in the diseasesettings of inherited retinal degenerations and age-related macular degeneration.Liter

113 etinal pigment epithelium, (3) photoreceptor degeneration, and (4) absence of other signs of a retina

114 phic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease, were found to be

115 n-infectious keratitis, corneal dystrophy or degeneration, and corneal neoplasm.

116 ciated diseases, including dementia, macular degeneration, and diabetes mellitus, in epidemiological

117 in the setting of high myopia, vitreoretinal degeneration, and encephalocele.

118 res, including glaucoma, age-related macular degeneration, and epiretinal membrane, require specific

119 s (gray matter inflammation), chronic axonal degeneration, and inflammatory demyelination due to loss

120 lum of wild-type mice leads to Purkinje cell degeneration, and Inpp5a overexpression decreases inosit

121 Glaucoma, macular degeneration, and near-sightedness searches more commonl

122 including reduction in inflammation and axon degeneration, and preservation of visual function as mea

123 linked to pancreatic inflammation, beta-cell degeneration, and the pathogenesis of type 2 diabetes (T

124 )R-induced cell death signaling and neuronal degeneration, are mitigated by an H(3)R antagonist.

125 ) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878).

126 volution of infarct and panorama of cellular degeneration as a synergistic or overlapping mechanism b

127 ation of Sarm1, a key regulator of Wallerian degeneration, as mice lacking the Sarm1 gene do not deve

128 Retinal degeneration associated with CLN2 disease manifests as a

129 from neurodegenerative disorder), Wallerian degeneration associated with injury is preceded by spher

130 new therapeutic target to counteract retinal degeneration associated with lysosomal dysfunction.

131 The brain degeneration associated with traumatic brain injury (TBI

132 nts with a diagnosis of an inherited retinal degeneration at the Kellogg Eye Center (University of Mi

133 indicates that monoaminergic nuclei undergo degeneration at the pre-symptomatic stage of Alzheimer's

134 monstrated a regional difference in cellular degeneration between cortex, corpus callosum, striatum,

135 utations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the ou

136 Although this "degeneration by regulatory evolution" does not require s

137 rks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy.

138 d with rapidly progressive childhood retinal degeneration, cardiomyopathy and almost undetectable pla

139 iabetic retinopathies, glaucoma, and macular degeneration, cause the death of retinal neurons and pro

140 er normal light conditions implying that the degeneration caused by rhodopsin signaling is not mediat

141 However, Scnn1a knockout in a degeneration-causing mutant background accelerated moton

142 Corticobasal degeneration (CBD) is a neurodegenerative tauopathy-a cl

143 pranuclear palsy [PSP], n = 10; corticobasal degeneration [CBD], n = 10; FTLD-TDP, n = 3; and Pick di

144 th mutations in PRPH2 exhibit severe retinal degeneration characterized by vast inter- and intra-fami

145 od and cone function and exacerbated retinal degeneration compared with Prph2R172W animals.

146 were less likely to have age-related macular degeneration compared with those not taking the drug (OR

147 lterations were detected at the onset of rod degeneration compared with wild type mice, including red

148 that regional differences in Purkinje neuron degeneration could provide novel insights into selective

149 he molecular mechanisms underlying Wallerian degeneration, demonstrated its involvement in non-injury

150 r age, gender, glaucoma, age-related macular degeneration, diabetic retinopathy, cataract, glaucoma s

151 progression of neurodegenerative and muscle degeneration disorders, the precise sequence of cellular

152 SARM1, an executor of axonal degeneration, displays NADase activity that depletes the

153 ion of skeletal muscle and subsequent muscle degeneration due to an uncontrolled autoimmune response;

154 tested in clinical trials for human retinal degeneration due to its potent neuroprotective effects i

155 Much like other forms of axon degeneration (e.g. developmental pruning, toxic insult f

156 ssion to exudative 'wet' age-related macular degeneration (exAMD) is a major cause of visual deterior

157 ons, potentially mitigating the evolutionary degeneration expected at genomic regions that cannot fre

158 Retinal pigment epithelium degeneration followed by retinal and choroidal thinning,

159 Rod-cone degenerations, for example, retinitis pigmentosa are lea

160 pathologies, including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (A

161 sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful

162 discover that the major isoform of a retinal degeneration gene, CRB1, was previously overlooked.

163 formation on the topics of cataract, macular degeneration, glaucoma, diabetic retinopathy, and near-s

164 concomitant ocular pathology such as macular degeneration, glaucoma, Sicca syndrome, epiretinal membr

165 Axonal degeneration has been recognized as a predominant driver

166 ecise sequence of cellular events leading to degeneration has not been fully elucidated.

167 ctasia type 2 (MacTel), a late-onset macular degeneration, has been linked to a loss in the retina of

168 r, rh-NGF) predominantly targeting secondary degeneration in a pONT rat model.

169 neuroimmune gene expression and hippocampal degeneration in alcohol use disorder (AUD) and other men

170 ion is hypothesized to cause motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS), but

171 process resulting in selective motor neuron degeneration in different disease variants has been post

172 Patients with low back pain may have fatty degeneration in erector spina and multifidus muscles wit

173 oteasome stress plays a major role in M cone degeneration in Lrat(-/-) model.

174 easome stress and completely prevents M cone degeneration in Lrat(-/-)Opn1sw(-/-) mice (a pure M cone

175 e of a lethal condition related to Wallerian degeneration in mice; the discovery of 'druggable' enzym

176 dence supporting gray matter involvement and degeneration in MS.

177 ined in some retinal regions but show severe degeneration in other regions.

178 tic mutation associated with neurofibrillary degeneration in part owing to reduced tau disaggregation

179 of NMNAT2 mutations that implicate Wallerian degeneration in rare human diseases; the capacity for li

180 (IP(3)) levels and ameliorates Purkinje cell degeneration in SCA17 knock-in mice.

181 TNF-alpha also triggers SARM1-dependent axon degeneration in sensory neurons via a noncanonical necro

182 Characterized by progressive photoreceptor degeneration in the central retina, disease progression

183 although all brain regions undergo neuronal degeneration in the disease.

184 In patients with LDH, fatty degeneration in the erector spina is more pronounced tha

185 rative disorder characterized by progressive degeneration in the frontal and temporal lobes.

186 hibition abates axonal dysfunction and slows degeneration in the inducible microbead occlusion model

187 maller baseline entorhinal volumes predicted degeneration in the medial temporal cortex, recapitulati

188 nal transport to the superior colliculus and degeneration in the optic nerve.

189 eovascularization due to age-related macular degeneration in the study eye were randomized and treate

190 ptotic markers in the retina, preventing the degeneration in vivo.

191 Inherited retinal degenerations (IRDs) are at the focus of current genetic

192 Retinal degeneration is a common clinical feature of ciliopathie

193 Identifying mechanisms that drive aortic degeneration is a crucial step in developing an effectiv

194 lar pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma, the leading caus

195 Age-related macular degeneration is a leading cause of vision loss worldwide

196 Age-related macular degeneration is a major cause of vision impairment in th

197 y resulting from retinal ganglion cell (RGC) degeneration is a prominent ocular manifestation of mito

198 Wallerian degeneration is a widespread mechanism of programmed axo

199 Secondary degeneration is believed to be the major contributor to

200 Meniscus degeneration is closely related to the progression of kn

201 trophy (GA) secondary to age-related macular degeneration is considered a single entity.

202 Aging-related organ degeneration is driven by multiple factors including the

203 progressive dry form of age-related macular degeneration is elusive and there is currently no therap

204 in, the cascade of intervertebral disc (IVD) degeneration is initiated by the disappearance of notoch

205 The progression of degeneration is not well understood, as complete sequenc

206 Photoreceptor degeneration is the most common cause of blindness in th

207 Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low back p

208 The intervertebral disc degeneration (IVDD)-related diseases occur in more than

209 halmology.(1-5) Humans with juvenile macular degeneration (JMD) show significant blood-oxygen-level-d

210 etinal degenerations and age-related macular degeneration.Literature discussed here focuses on the ec

211 ed common pathways shared with other retinal degeneration models.

212 rk analysis visualized which measures of IVD degeneration most related to pain by sex.

213 ive keratoconus (n = 589), pellucid marginal degeneration (n = 11), and laser in situ keratomileusis-

214 a clinical diagnosis of an inherited retinal degeneration (n = 128) participated in an interviewer-ad

215 n real-world neovascular age-related macular degeneration (nAMD) patients.

216 atients with neovascular age-related macular degeneration (nAMD) treated with intravitreal injection

217 atients with neovascular age-related macular degeneration (nAMD) who received anti-vascular endotheli

218 libercept in neovascular age-related macular degeneration (nAMD).

219 atients with neovascular age-related macular degeneration (nAMD).

220 atients with neovascular age-related macular degeneration (nAMD).

221 Ganglionitis, characterized by neuronal degeneration, necrosis, and mononuclear leukocyte infilt

222 boembolic complications and structural valve degeneration needs further assessment.

223 This may be attributed to axon degeneration/neuronal death and sustained neuroinflammat

224 herapies for neovascular age-related macular degeneration (NVAMD).

225 highly correlated with the extent of retinal degeneration observed in OCT or fundus photographs; by u

226 in goal is to diagnosis before morphological degeneration occurs.

227 Pathological degeneration of axons disrupts neural circuits and repre

228 ation (WD) is a process of autonomous distal degeneration of axons upon injury.

229 f the Drosophila retina leads to age-related degeneration of both glia and neurons, preceded by an ab

230 eads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which

231 Degeneration of cerebellar Purkinje cells occurs at an e

232 eptors and a role for apoptosis in secondary degeneration of cones, highlighting the importance of th

233 s neurodegeneration in SMA mice and prevents degeneration of cultured primary spinal cord neurons der

234 Mutations in PINK1 and Parkin/PRKN cause the degeneration of dopaminergic neurons in familial forms o

235 nery to alpha-synuclein accumulation and the degeneration of dopaminergic neurons, two major features

236 lial abundance, upregulated GFAP expression, degeneration of LC fibers, decreased striatal DA metabol

237 nto the establishment and pathophysiological degeneration of neural circuitry in Parkinson's disease.

238 allidus of Abeta + ET1 rats showed extensive degeneration of neuronal cells compared with ET1 rats al

239 ET-1 has been shown to promote degeneration of optic nerve axons and apoptosis of retin

240 gates, accelerate the severe and progressive degeneration of parvalbumin-positive (PV(+)) neurons in

241 (2+) dysregulation and primary, nonapoptotic degeneration of photoreceptors and a role for apoptosis

242 Degeneration of photoreceptors caused by excessive illum

243 mined the natural history of dysfunction and degeneration of retained rods by serially evaluating pat

244 ibute to loss of PDE6 and, as a consequence, degeneration of retinal cells in eye diseases linked to

245 netic diseases, characterized by progressive degeneration of skeletal and cardiac muscle.

246 mental data, during concurrent 4-AP therapy, degeneration of the macular retinal nerve fibre layer wa

247 coma, TNF-alpha induces SARM1-dependent axon degeneration, oligodendrocyte loss, and subsequent retin

248 branch block may be due to conduction system degeneration or a reflection of myocardial pathology.

249 older with a diagnosis of exudative macular degeneration or diabetic macular edema requiring bilater

250 sed statistics unraveled progressive network degeneration originating from the motor cortex and expan

251 , severed axons undergo programmed Wallerian degeneration over several following days.

252 ich has been previously implicated in axonal degeneration (p = 1.76 x 10(-08) with amyotrophic latera

253 ted fast-cycling stem cells, which caused JE degeneration, PDL destruction, and bone resorption.

254 Progressive rod-cone degeneration (PRCD) is a small protein localized to phot

255 jections for neovascular age-related macular degeneration presented 4 weeks after his most recent int

256 gion of the substantia nigra involved in the degeneration process of Parkinson disease.

257 on retinal neurons via influencing secondary degeneration process.

258 ngoing clinical trials for inherited retinal degenerations, quantifiable and reliable outcome measure

259 questionnaire, known as the Michigan Retinal Degeneration Questionnaire, is psychometrically validate

260 Degeneration rates of S- and M-cones are negatively corr

261 model of acute stress-induced photoreceptor degeneration recapitulates the epigenetic hallmarks of h

262 1as and its antisense transcript, cerebellar degeneration related protein 1 (CDR1).

263 ghtedness, diabetic retinopathy, and macular degeneration, respectively, with all pairwise comparison

264 decades since the discovery of the Wallerian degeneration slow (Wld(S)) mouse, research has generated

265 e early drusen stage to the advanced macular degeneration stage that leads to blindness, remains unkn

266 g a centrifugal pattern of white matter (WM) degeneration starting from deep brain areas, which is co

267 man animal research assumes that Alzheimer's degeneration starts in the entorhinal cortices, before s

268 3 and results in vascular smooth muscle cell degeneration, stroke, and dementia.

269 tion and may suggest that other mediators of degeneration, such as DR6 and SARM1, mediate post-sphero

270 psin signaling protected photoreceptors from degeneration suggesting that the pathway activated by th

271 ina found in these mutants 2 months after PR degeneration suggests moderate, stereotyped remodeling i

272 oach to the spectrum of frontotemporal lobar degeneration syndromes provides a useful framework with

273 critical to understanding sight and retinal degenerations that lead to blindness.

274 In age-related macular degeneration, the retinal pigment epithelium can be dama

275 ender, and a documented diagnosis of macular degeneration, the use of a BLF IOL was not predictive of

276 ed chromatin accessibility and photoreceptor degeneration, thereby elucidating a potential new therap

277 In retinal degenerations, these same gap junctions mediate oscillat

278 uggest that Abeta drives neurite and synapse degeneration through an array of tau-dependent and indep

279 often associated with axonal detachment and degeneration throughout the CNS, including in the optic

280 In turn, NRF2 mitigates lethal intestine degeneration upon autophagy loss.

281 an epiretinal membrane, age-related macular degeneration, vitreomacular traction, and cystoid macula

282 The epithelium degeneration was associated with a rapid loss of the pro

283 those from the nodular zone, and this early degeneration was associated with selective dysregulation

284 Bioprosthesis degeneration was observed in 7 cases and annuloplasty fa

285 Wallerian degeneration (WD) is a process of autonomous distal dege

286 ns of 1094 patients with age-related macular degeneration, we generated a vocabulary of 20 local and

287 vitamin formulations for age-related macular degeneration were obtained.

288 ematurity (ROP), and wet age-related macular degeneration (wet AMD) have been found to have elevated

289 ma, Brolucizumab for wet age-related macular degeneration (wet AMD), Luxturna for retinitis pigmentos

290 or the G90D mutation did not exhibit retinal degeneration whereas homozygous mice exhibited progressi

291 l pigment epithelium (RPE) and photoreceptor degeneration which was similar to the advanced STGD1 phe

292 se-dependent neuronal dysfunction and axonal degeneration, which are rescued by genetic or pharmacolo

293 nograms (ERGs) and progressive photoreceptor degeneration, which is presumed to be driven by metaboli

294 n and decreased oxidative stress and retinal degeneration, which resulted in improved visual function

295 come(s) in patients with age-related macular degeneration who received anti-VEGF treatment were inclu

296 ADRD, cognitive impairment, or neurological degeneration, who developed appendicitis between ages 68

297 dividuals with retinal damage due to macular degeneration will have stereopsis.

298 nd multiple subtypes of frontotemporal lobar degeneration with tau inclusions.

299 mong LATE-NC, ADNC, and frontotemporal lobar degeneration with TDP-43 (FTLD-TDP).

300 o show reciprocal changes in activity during degeneration, with increased Tor activity and decreased