ライフサイエンスコーパス: degradable

1 versus benign, and persistent versus readily degradable.

2 rted that selectively and efficiently yields degradable ABA-block polymers, incorporating 6-23 wt % C

3 Herein, an autonomous and degradable, active microneedle delivery platform is intr

4 Degradable aliphatic polyesters are the cornerstones of

5 e surface ligands capable of binding to DNA, degradable aliphatic-ester dendritic scaffolds, and hydr

6 It gives a detailed summary of non-degradable and biodegradable systems and their applicati

7 The resulting P(MBL)ROP is degradable and can be readily postfunctionalized into cr

8 Degradable and cell-compatible hydrogels can be designed

9 The cryoGelMA conduit is degradable and could be completely degraded in 2-4 month

10 uran as the monomer, producing a new type of degradable and depolymerizable poly(enol ether).

11 ppearance in the literature, a wide range of degradable and non-degradable polymers have been demonst

12 on fibroblast migration through collagenase-degradable and plasmin-degradable hydrogels and on smoot

13 arth abundant materials which are also fully degradable and recyclable.

14 oting characteristics, but it is also highly degradable and thus unsuited for several applications.

15 t the structural differences between readily degradable and undegradable micelles are rather minor, p

16 Herein, we report a flexible, biologically degradable and wirelessly operated electrochemical senso

17 ition, a strain that expresses a temperature-degradable ATPase subunit of the 19S regulatory complex

18 gen species (ROS), is an intralysosomal, non-degradable, auto-fluorescent macromolecule which accumul

19 This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions prov

20 polymers fulfill an unmet need for a readily degradable biocompatible polycarbonate.

21 this, three different types of macroscopic, degradable biomaterial hydrogel scaffolds were employed:

22 ), ammonia (NH(3)), ethylene (C(2)H(4)), and degradable bioplastics polyhydroxybutyrate (PHB).

23 the availability of appropriate orthogonally degradable block copolymers for use as templates.

24 A new class of bio-based fully degradable block polyesters are pressure-sensitive adhes

25 f drugs with SPIONs including thermo- and pH-degradable bonds, amide linkage, redox-cleavable bonds,

26 vant pharmaceutical that is otherwise poorly degradable by a bacterial community encountered in conve

27 These materials could be made non-degradable by epoxidation of the OND linkers without slo

28 gion of p73 results in a protein that is not degradable by Mdm2.

29 resulted in a p53 protein that was no longer degradable by the viral proteins.

30 rugs through cleavage of the self-immolative degradable caging groups.

31 Non-degradable capsules show long-term stability, whereas th

32 ading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactiv

33 ether, we believe that tethering proteins by degradable carbamate linkers is a promising strategy to

34 f lysozyme to poly(ethylene glycol) (PEG) by degradable carbamate linkers.

35 ial cells occurs when a surplus of an easily degradable carbon source (e.g., volatile fatty acids, VF

36 hods for green synthesis of useful naturally degradable carbon-based nanomaterials, to device operati

37 dy showed an enhanced clearance for the acid-degradable carrier, even after multiple dosing.

38 Therefore, these acid-degradable cationic nanohydrogel particles can be consid

39 nhanced in vitro gene knockdown for the acid-degradable cationic nanoparticles compared to their non-

40 uccessful application of peptide linkers for degradable cationic polymers and DNA release.

41 Degradable cationic polymers are desirable for in vivo n

42 Degradable, cationic poly(beta-amino ester)s (PBAEs) wit

43 n yeast cells, as well as other cells with a degradable cell wall.

44 nd differentiation, can be controlled within degradable, cell-compatible hydrogels with temporal tuni

45 s 1.8 days (acetaminophen, ibuprofen) to not degradable (chlorthalidone, fluconazole).

46 These results suggest that the degradable Chol-PVA-PEG polymer is able to self-assemble

47 expression of either the wild-type or a non-degradable CKAP2 led to a mitotic arrest with monopolar

48 The capture-release capability of these degradable coatings is harnessed by a mixing chamber and

49 Using MMP-degradable collagen lattices or nondegradable substrates

50 turated acids resins, pharmaceutics, and bio-degradable/ -compatible polymers, respectively.

51 drug delivery device, where air is used as a degradable component of our material to control drug rel

52 lications is limited owing to the use of non-degradable components.

53 The well-degradable compounds showed slow equilibration and the l

54 n example for extremely difficult and slowly degradable compounds, CO2 production was close to the th

55 ponents, including biodegradable polymer/non-degradable conductive polymer/dopant, biodegradable cond

56 pon Ca(2+) binding, native CaM assumes a non-degradable conformation, which most of the age-damaged s

57 When implanted subcutaneously in rats, degradable constructs containing VEGF and arginine-glyci

58 col) (PEG) hydrogels, with a proteolytically degradable core and a non-degradable shell.

59 er significantly decreased toxicity over non-degradable counterparts.

60 Introduction of various degradable cross-linking agents into the system resulted

61 cores around which shells composed of NIPAm, degradable crosslinker N, N'-bis (acryloyl) cystamine (B

62 be present when either the degradable or non-degradable crosslinker was used.

63 t study, bioactive hydrogels with a protease-degradable crosslinker were loaded with hepatocyte and v

64 lsion polymerization with a synthesized acid-degradable crosslinker.

65 ized with either disulfide or hydrolytically degradable crosslinkers, is critical to the high efficie

66 We found that the expression of a non-degradable cyclin B in embryos also caused an anaphase a

67 d attached to the arrested spindles, and non-degradable cyclin B levels remained high on both the cen

68 proteasome inhibitor or by expression of non-degradable cyclin B, Cdk inhibitors will nonetheless ind

69 nction, principally by overexpression of non-degradable cyclin B1 or securin, we find here that separ

70 We address this issue by reporting modular degradable dendrimers that achieve the required combinat

71 hMSCs encapsulated in hydrogels with the MMP-degradable Dex-peptides had elevated levels of ALP activ

72 The degradable diblock conjugate (2P-EPI) was synthesized by

73 end, we designed second-generation backbone-degradable diblock N-(2-hydroxypropyl)methacrylamide (HP

74 olymerizable siRNA pro-drug conjugate with a degradable, disulfide linkage was prepared.

75 em consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-resp

76 , which is integrated constructed as a novel degradable drug device, demonstrates surprisingly effici

77 In addition, the hydrogel is designed to be degradable during cell culture, generating extra space t

78 ers were then thermally cross-linked to form degradable elastomeric structures.

79 A versatile method for preparing amorphous degradable elastomers with tunable properties that can b

80 ductive carbon-black-DNA hydrogels acting as degradable electrical fuses, and (iv) a polyacrylamide-D

81 classes of biologically and environmentally degradable electronic devices.

82 for applications such as bioelectronics and degradable electronics for which traditional semiconduct

83 ess in both nondegradable gels and gels with degradable elements.

84 ly bonding the drug through a hydrolytically degradable ester linkage to a common hydrophilic polymer

85 By using these principles, we designed degradable films capable of extended release as well as

86 tion of WNT signaling by expression of a non-degradable form of beta-catenin specifically in SOX2-pos

87 t and relies on the presence of a proteasome degradable form of beta-catenin.

88 contrast, neuroblasts overexpressing the non-degradable form of canonical APC/C substrates required f

89 approaches as well as expression of the non-degradable form of Cx43 significantly restore its accumu

90 t strain in which a functional but a rapidly degradable form of eIF6 fusion protein was synthesized f

91 escribe the effects of over-expressing a non-degradable form of geminin in various cell lines.

92 activation by in utero introduction of a non-degradable form of the YAP gene (YAP 5SA) causes product

93 hich destabilizes the cbb(3) oxidase into a "degradable" form, perhaps by altering its conformation.

94 uffer from the unintentional scission of the degradable functionalities on the polymer backbone, whic

95 orporating complex main-chain structures and degradable functionalities.

96 g microneedles loaded with insulin and a non-degradable glucose-responsive polymeric matrix, and fabr

97 ild-type mouse class I MHC (H-2K(b)) but not degradable glycosylation mutants of H-2K(b) induced ER s

98 We examined a transgenic mouse in which degradable green fluorescent protein (GFP) is driven by

99 ugates and free drugs, the second-generation degradable high-molecular weight conjugates showed disti

100 results indicate that the second-generation degradable HPMA copolymer carrier can provide an ideal p

101 different therapeutic delivery systems, acid degradable hydrogels and nanoparticles.

102 n through collagenase-degradable and plasmin-degradable hydrogels and on smooth muscle cell migration

103 ochemical and physical signals in macroscale degradable hydrogels are engineered that can regulate ph

104 Finally, an enzymatically-degradable hydrogels of P(MAA-co-NVP) crosslinked with t

105 The nanocarrier-based degradable hydrogels provided controlled release of lact

106 oxyethyl methacrylate to form hydrolytically degradable hydrogels through free-radical-initiated cros

107 ight into the design of new cell-compatible, degradable hydrogels to understand and modulate cellular

108 oly(ethylene glycol) (PEG) nanocarrier-based degradable hydrogels were developed for the controlled r

109 strategy for the construction of multimodal degradable hydrogels, which can be utilized to guide the

110 mooth muscle cell migration through elastase-degradable hydrogels.

111 ons, even when all DOC compounds are equally degradable: (i) >15% of an initial DOC pulse resists deg

112 le, injectable alginate microspheres and non-degradable, implantable poly(ethylene vinyl acetate) mat

113 ct local delivery via diffusive release from degradable implants or direct intra-cerebral injection c

114 ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing C

115 NP) formulations, and was found to be slowly degradable in phosphate buffered saline (PBS) but more r

116 The particles are fully degradable in response to esterases due to an embedded e

117 When a degradable inimer was applied, the hyper-stars showed fa

118 In this work, we engineered degradable, injectable alginate microspheres and non-deg

119 a shunts were manufactured with or without a degradable inner core designed to modulate aqueous humor

120 polymer/dopant or biodegradable polymer/non-degradable inorganic additives.

121 eutic antifungal agents in humans and easily degradable insecticides in agriculture.

122 hanically plastic, nanoporous, and minimally degradable interpenetrating networks of reconstituted BM

123 in cell culture and xenograft models, a non-degradable IP3R3 mutant sensitizes tumour cells with low

124 ere, we use chemo-proteomics to annotate the degradable kinome.

125 dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanoshee

126 in which either disulfide-responsive or non-degradable linkages are incorporated.

127 radable nanomaterials incorporating specific degradable linkages that respond to various stimuli and

128 ubicin (DOX) to HPMA copolymer, and an MMP-2-degradable linker (PLGLAG) connected tumor-homing and -p

129 an ARV drug tenofovir alafenamide (TAF) with degradable linkers that can be designed to control relea

130 tion in peripheral tissues with programmable degradable linkers.

131 ed to gels through environmentally sensitive degradable linkers.

132 A non-degradable lipid radiolabel showed that lipid components

133 constant was independently verified using a degradable lipid radiolabel that eliminated from the bra

134 Herein, we identify promising degradable lipidoids and describe new design criteria th

135 Here, we have synthesized 1,400 degradable lipidoids and evaluate their transfection abi

136 o either free siRNA or siRNA-loaded non-acid-degradable lipoplex formulations, respectively.

137 conductive (3 x 10(5) S m(-1) ) features in degradable materials at ambient conditions over large ar

138 some contents appear degraded, but some non-degradable materials can subsequently be found in more r

139 omising strategy of utilizing 100% green and degradable materials in novel electronic and energy harv

140 are versatile, potentially bio-based and/or degradable materials widely applied in the manufacture o

141 erivatives will enable researchers to access degradable materials with tunable thermal, physical, and

142 shrinkage materials and preparation of (bio)degradable materials) of rROP monomer-containing materia

143 en at much higher loadings, does not produce degradable materials.

144 nefit from having sustainable, nontoxic, and degradable materials.

145 Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-sca

146 A modular synthetic approach to degradable metathesis polymers is presented using acetal

147 tic (i.e., non-degradable) or dynamic (i.e., degradable) microenvironments.

148 APCs that phagocytosed the acid-degradable microgels containing ovalbumin were capable o

149 The acid-degradable microgels developed in this article should th

150 Ovalbumin is released from the acid-degradable microgels in a pH-dependent manner; for examp

151 rotecting the structural integrity of highly degradable miRNAs, providing a useful means for maintain

152 l base materials, formation chemistries, and degradable moieties is necessary to achieve the appropri

153 a further understanding of how enzymatically-degradable multi-stage polymeric carriers can be used fo

154 Targeting the expression of gai (a non-GA-degradable mutant form of GAI) in the root meristem disr

155 design, synthesis and properties of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copo

156 cently, we developed 2nd generation backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copo

157 y, which will guide the development of these degradable nanoconstructs to reach their potential for c

158 ondition in such patients, oxidation-induced degradable nanogels for iron chelation were rationally d

159 scribe the synthesis and characterization of degradable nanogels that display bulk erosion under phys

160 Thus, we have demonstrated the synthesis of degradable nanogels that erode under conditions and on t

161 lowed for the synthesis of cross-linked (bio)degradable nanogels.

162 The generality of this degradable nanoparticle formulation should allow for the

163 esized that controlled release of PHCCC from degradable nanoparticles (NPs) might address these chall

164 ores via diffusion produced thermosensitive, degradable nanoparticles with low density, or hollow, co

165 ctive small molecules is conjugation to less degradable nanoparticles; here we report the synthesis a

166 dental device fracture or migration, the non-degradable nature of these materials risks intestinal ob

167 utility of OND linkers in the preparation of degradable network materials with potential applications

168 BPLPs are degradable oligomers synthesized from biocompatible mono

169 ells that are chemically functionalized with degradable oligonucleotide 'Velcro', allowing rapid, spe

170 psules show long-term stability, whereas the degradable ones break down their shells, enabling the co

171 The main biotransformation product, ATO, was degradable only in aerobic conditions, as evidenced by a

172 isfolded polypeptides into harmless protease-degradable or biologically active native proteins.

173 rly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural EC

174 ies were shown to be present when either the degradable or non-degradable crosslinker was used.

175 very large numbers of ionically crosslinked (degradable or nondegradable) barrier layers cannot block

176 we have generated a toolkit of conditionally degradable or stabilisable orthologous dCas9 or Cpf1 eff

177 modulate cell response in static (i.e., non-degradable) or dynamic (i.e., degradable) microenvironme

178 of the aquifers, which is present as pyrite, degradable organic carbon, and geogenic U(IV) minerals.

179 uch as biosensors that are biocompatible and degradable over a controlled period of time can be forme

180 plicability in the characterization of other degradable particle constructs.

181 n, which may be used for the design of novel degradable pathogen-specific, and hence, environmentally

182 In vitro testing of this degradable PCL delivery platform reveals approximately 4

183 division despite the presence of nuclear non-degradable Pds1.

184 e peptide-modified, matrix metalloproteinase-degradable PEG hydrogels formed lumenized epithelial sph

185 able attention has been paid on synthesis of degradable PEI derivatives using low MW one because low

186 ry to incorporate a matrix metalloproteinase-degradable peptide crosslinker (KKCGGPQG downward arrowI

187 diacrylate derivatives with proteolytically degradable peptide sequences included in the backbone of

188 stered until released by cleavage of the MMP-degradable peptide tether triggered by cell-secreted MMP

189 -terminus of a matrix metalloproteinase(MMP)-degradable peptide, which was then easily co-polymerized

190 In this work, enzymatically degradable peptide-HPMA copolymers were synthesized by R

191 of enzymatic reaction of unstable and slowly degradable peptides with trypsin, respectively, and sugg

192 For polar and more degradable pesticides, not many data on long-term persis

193 A degradable pH-sensitive hydrazone bond between a long sh

194 icle-based DNA delivery system composed of a degradable, pH-sensitive poly-beta amino ester and poly

195 Here we report a class of biorenewable and degradable plastics, based on copolymers of gamma-butyro

196 stamine (BAC) cross-linked core out of a non-degradable pNIPAM shell.

197 Degradable poly(amine-co-ester) (PACE) terpolymers hold

198 morphogenetic protein over several days from degradable poly(beta-amino ester) based multilayers, thi

199 ently reported the parallel synthesis of 140 degradable poly(beta-amino esters) via the conjugate add

200 capsulated in cell-adhesive, proteolytically-degradable poly(ethylene) glycol-based hydrogels.

201 ve studies of bulk samples of hydrolytically degradable poly(lactic acid) (PLA) vs core-shell block c

202 lations based on conventional hydrolytically degradable poly(lactic-co-glycolic acid) (PLGA) and reac

203 cartilage regeneration, was encapsulated in degradable poly(lactic-co-glycolic acid) (PLGA) micropar

204 We present the first well-defined degradable poly(phosphonate)s with adjustable UCST.

205 id) (PLGA) and reactive oxygen species (ROS)-degradable poly(propylene sulfide) (PPS).

206 nation (>90% alternating diads) and produces degradable poly(vinyl ether) materials with low dispersi

207 To this end, we generated a library of >500 degradable, poly(beta-amino esters) for potential use as

208 ogels releasing DNA-anchored compounds, (ii) degradable polyacrylamide-DNA hydrogels encapsulating na

209 ormation of carbon dioxide and epoxides into degradable polycarbonates (CO(2)-based copolymer) has be

210 Other degradable polycationic gene carriers such as polyamidoa

211 the recent developments on these three major degradable polycations as promising carriers for deoxyri

212 le method to prepare clinically translatable degradable polyesters.1 A variety of functional groups h

213 FTOH biotransformation pathways toward more degradable polyfluoroalkylcarboxylic acids, such as 5:3

214 d within newly formulated alginate-glutamine degradable polylysine (A-GD-PLL) microcapsules.

215 NaYF4 :Tm.Yb upconverting nanocrystals in UV-degradable polymer capsules, it is possible to access ef

216 demonstrate, for the first time, a backbone-degradable polymer directly synthesized via CVD.

217 the need for an environmentally responsive, degradable polymer has risen to improve treatment outcom

218 cularly, the degradability of a conventional degradable polymer is typically enabled by cleavable gro

219 combination of Treg inducing factors through degradable polymer microspheres (TRI microspheres; TGF-b

220 nase inhibitor, masitinib, was released from degradable polymer microspheres delivered from the surfa

221 ned coating a commercial gelatin sponge with degradable polymer multilayer films containing vancomyci

222 capsulating a single siRNA molecule within a degradable polymer nanocapsule with a diameter around 20

223 d PPF can be covalently cross-linked to form degradable polymer networks, which have been widely expl

224 catalytic activity is critical to improving degradable polymer production.

225 ion of nanoparticles formulated with an acid degradable polymer shell and encapsulated HSA exhibited

226 This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degrada

227 f chemokine ligand 22 (CCL22), composed of a degradable polymer with a proven track record of clinica

228 delivery using a far ultraviolet (UV) light-degradable polymer, which allows noninvasively triggered

229 to yield a well-defined, alkene-substituted degradable polymer, which was used as a common backbone

230 An acid-degradable polymer-caged lipoplex (PCL) platform consist

231 esign principles of traditional and backbone degradable polymer-drug conjugates as well as the develo

232 tion of mRNA for delivery to the lungs using degradable polymer-lipid nanoparticles.

233 as encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of

234 uinoline-based TLR7/8 agonist to 50-nm-sized degradable polymeric nanogels the potency of the agonist

235 is study, antigens were encapsulated in acid-degradable polymeric particle carriers to cascade cytoto

236 reated a diverse library of hundreds of acid-degradable polymers and chemically linked ARBs to the po

237 Degradable polymers are desirable for the replacement of

238 processes have implications in the design of degradable polymers as supramolecular scaffolds for biol

239 carbonates for the realization of functional degradable polymers by ring-opening polymerisation has d

240 ct that this work will enable preparation of degradable polymers by ROMP for biomedical applications,

241 These cationic, degradable polymers contain pyridyldithio functionalitie

242 By this means, non cell-toxic, degradable polymers exhibiting UCST behavior in water be

243 Efforts to synthesize degradable polymers from renewable resources are deterre

244 terature, a wide range of degradable and non-degradable polymers have been demonstrated in drug deliv

245 new class of self-assembling, photo- and pH-degradable polymers of the polyacetal family is reported

246 Herein we report new degradable polymers that stabilize proteins to environme

247 al product-derived materials and functional, degradable polymers to provide a new platform for functi

248 growth factor bFGF can be incorporated into degradable polymers used as delivery devices for hepatoc

249 These degradable polymers were then employed as excipients for

250 DO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR spectroscopy a

251 Though numerous applications require degradable polymers, there are surprisingly few polymer

252 ketal that has been widely employed in acid degradable polymers.

253 or a new class of ROMP monomers that lead to degradable polymers.

254 A degradable polyphosphoester (PPE)-based cationic nanopar

255 rin (LAM-OH) is a highly abundant, nontoxic, degradable polysaccharide found in marine organisms and

256 s to a tissue engineering approach that uses degradable porous material scaffolds integrated with bio

257 201 in water makes it the first example of a degradable porous solid carrier for such fumigants.

258 for adaptation with different nanoparticles, degradable pre-polymers, and various therapeutics.

259 f p53 by deletion also results in a non-Mdm2-degradable protein.

260 persists over months at the injection site, degradable PSC7A primes a transient acute inflammatory r

261 We present here a fully degradable, remotely controlled, implantable therapeutic

262 ttlebrush and brush-arm star copolymers with degradable segments.

263 ed SELPs with matrix metalloproteinase (MMP) degradable sequences inserted in distinct regions of the

264 rthermore, both adhesive and proteolytically degradable sequences were required for cell migration to

265 s progresses normally in the presence of non-degradable Sgo1, indicating that degradation of Sgo1 is

266 a proteolytically degradable core and a non-degradable shell.

267 h suggests that cholesterol analogs with non-degradable side chains represent a novel class of anti-m

268 ficial hydrogel matrices presenting protease-degradable sites, cell-adhesion motifs, and growth facto

269 esterol because (i) a non-hydrolyzable and a degradable SL analog elevated cellular cholesterol to si

270 ost acts as a significant and preferentially degradable source of bioavailable carbon in Arctic fresh

271 and nonfood applications as a renewable and degradable source of carbon and energy.

272 Differently from muscle, PG in liver is a degradable source of glucose and readily depleted by fas

273 cationic nanoparticles compared to their non-degradable spermine analogues.

274 eptide binding, removal, and conversion to a degradable subfragment) are mediated by features that re

275 Bioavailability limitations of a degradable substrate can therefore either improve the ov

276 followed by transit peptide conversion to a degradable substrate.

277 es flanked by matrix metalloproteinase (MMP) degradable substrates.

278 h(-1), respectively), despite identical MMP degradable substrates.

279 safe mechanism that expands the range of RQC-degradable substrates.

280 gate several drawbacks associated with other degradable sustained delivery technologies in the market

281 success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices

282 rubicin, respectively, through a cathepsin B degradable tetrapeptide linker (-Gly-Phe-Leu-Gly-).

283 Doxorubicin was linked via a lysosomally degradable tetrapeptide sequence to N-(2-hydroxypropyl)m

284 the fabrication of conformal, hydrolytically degradable thin films capable of administering sustained

285 e PEG-LA nanocarriers with 4-arm PEG-NHS via degradable thioester bonds.

286 ilable; (2) many biocides are short-lived or degradable through abiotic and biotic processes, but som

287 building blocks known to be biocompatible or degradable to natural metabolites in vivo, are described

288 ynthesis and characterization of a series of degradable ultra-pH sensitive (dUPS) polymers that ampli

289 recalcitrant under anaerobic conditions but degradable under aerobic conditions can be biodegraded a

290 mechanical deformations, but are completely degradable under enzymatic action.

291 The resulting hydrogels are degradable under simulated physiological conditions and

292 y control, while incorporation of responsive degradable units enables cell- and/or user-directed degr

293 However, degradable upper critical phase separation (UCST) block

294 While a non-degradable UPS polymer induces granulomatous inflammatio

295 vector encoding a non-phosphorylatable, non-degradable variant of IkappaBalpha resulted in normal in

296 The synthesis and characterization of a degradable version of poly(acrylic acid), poly(glyceric

297 d only very slowly over multiple passages, a degradable version of the polycation was observed to mak

298 The persistence of PPs ranged from readily degradable with a dissipation half-life (DT50) as short

299 n and eventual disintegration into naturally degradable yet potentially reusable byproducts.

300 Here, using 3D culture of human HSPCs in a degradable zwitterionic hydrogel, we achieved substantia