ライフサイエンスコーパス: degradation

1 velopment by triggering PCD and tapetal cell degradation.

2 d for blocking MRE11-mediated nascent-strand degradation.

3 s AHL4-mediated suppression and promotes TAG degradation.

4 izing FBW7-mediated C-MYC ubiquitination and degradation.

5 alent PROTACs, with <10 nM DC(50)'s and >85% degradation.

6 cancer cells and susceptibility to nuclease degradation.

7 ht), and subsequent MS-analysis following UV degradation.

8 f LEKTI or its susceptibility to mesotrypsin degradation.

9 , that are key in extracellular matrix (ECM) degradation.

10 perones can mediate both protein folding and degradation.

11 tected areas preventing both forest loss and degradation.

12 cal redox, reaction mechanism, kinetics, and degradation.

13 a promoting the AMPKbeta1 ubiquitination and degradation.

14 d amino acid depletion and protects LRS from degradation.

15 in in the OF prior to basement membrane (BM) degradation.

16 CYP2B6 protein but did not stimulate CYP2B6 degradation.

17 e of the main reasons for accelerated device degradation.

18 ch enhances stability from nuclease mediated degradation.

19 7-me3, resulting in autophagy-mediated lipid degradation.

20 ar disulfide bonds and are essential for ECM degradation.

21 x metalloproteinases for pericellular matrix degradation.

22 eased expression of proteins involved in GSH degradation.

23 ein and rescues WEE1 from ubiquitin-mediated degradation.

24 ases to lysosomes and reduces the autophagic degradation.

25 e absence of HUWE1 and may contribute to MYC degradation.

26 thus mainly abrogating the increased protein degradation.

27 ver, they are diverted to late endosomes for degradation.

28 e subsequently delivered to the lysosome for degradation.

29 ncluding urea, lactate, and salivary protein degradation.

30 9 molecules protects PHO2 mRNA from complete degradation.

31 3 ubiquitin ligase activity regarding PML II degradation.

32 m16-depedent Vimentin polyubiquitination and degradation.

33 dynamics, including protein translation and degradation.

34 rotect RGS2 from FBXO44-mediated proteasomal degradation.

35 sSAS-6 and targets it for ubiquitin-mediated degradation.

36 t pathway and trafficked to the lysosome for degradation.

37 tion by accelerating pathogenic IgG antibody degradation.

38 retinal cells due to impaired endo-lysosomal degradation.

39 teins, including HIF-1alpha, for proteasomal degradation.

40 on and subsequent FBXW7-mediated proteasomal degradation.

41 s S429A substitution protects MDM2 from auto-degradation.

42 to identify genes involved in lignocellulose degradation.

43 and tensin homologue (PTEN) for proteasomal degradation.

44 NG through direct interaction to prevent its degradation.

45 ntext of a ubiquitin ligase, lead to protein degradation(1).

46 rubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed to be toxic,

47 cking strength determines the timing of Sic1 degradation, a key cell cycle event.

48 provides a blueprint for evaluating targeted degradation across entire gene families to accelerate un

49 e heat wave events are now causing ecosystem degradation across marine ecosystems.

50 P7C3-A20 also protected mice from BBB degradation after acute TBI.

51 sufficient to target Katanin for proteasomal degradation after meiosis, whereas phosphorylation at th

52 ectric switching in BiFeO(3) with no sign of degradation after ~10(10) switching cycles.

53 BR treatment stimulates ULP1a degradation, allowing SUMOylated BZR1 to accumulate and

54 In the kynurenine pathway for tryptophan degradation, an unstable metabolic intermediate, alpha-a

55 microscopy can be related directly to device degradation and are attributed to the significantly diff

56 However, DNs are prone to nuclease-mediated degradation and are unstable in low Mg(2+) conditions; t

57 neuron axons, motor neuron death, and muscle degradation and atrophy can also be recapitulated in thi

58 ar functions, from cell division to lysosome degradation and autophagy.

59 Extracellular enzymes, lignin degradation and cell growth are crucial phenotypes of li

60 DF paralogs act redundantly to mediate mRNA degradation and cellular differentiation.

61 d metabolic stability from nuclease-mediated degradation and exhibit enhanced interactions with plasm

62 ha-amylase activity, leading to rapid starch degradation and increase in soluble sugars, ascorbate, a

63 Stage III is controlled by polymer degradation and involves release of the remaining drug.

64 of biocidal metal cations and soil solutes, degradation and loss of crystallinity of cellulosic poly

65 Degradation and loss of natural habitat is the major dri

66 itial steady-state balance of production and degradation and measure half-life by quantifying the rat

67 restation, yet few have accounted for forest degradation and natural disturbances-processes that occu

68 to be used as an analytical tool to measure degradation and PTMs in-line with therapeutic production

69 , as well as the relevant timescales of soil degradation and recovery.

70 amine labeled homopolymer depots showed that degradation and release of the depot coincided with the

71 es in roughly the same time frame as APOBEC3 degradation and that this activity is prevalent in patie

72 wnregulation of genes associated with matrix degradation and upregulation of genes associated with ce

73 ved in drug resistance (drug extrusion, drug degradation, and DNA damage repair) and using rate const

74 ding to microglia activation, perineural net degradation, and impaired NMDA receptor function.

75 umed that decoy-bound TFs are protected from degradation, and in this case decoys function to buffer

76 Deforestation and forest degradation around the world endanger the functioning of

77 Unlike degradations associated with antibody drug conjugates, s

78 ters, as well as reported mechanisms of PFAS degradation at the anode surface.

79 des were completely resistant to proteolytic degradation, boosting their potential for biomedical app

80 nascent RNAs to promote their maturation or degradation but how the balance between these activities

81 hitectures in regulating proteasome-mediated degradation, but the proteins that selectively recognize

82 cules are selectively targeted for lysosomal degradation by an autophagy-dependent mechanism that inv

83 nitrate assimilation, restriction of protein degradation by autophagy and subsequent N remobilization

84 through their recognition, disassembly, and degradation by ClpC1, which requires disordered ends in

85 Rhythmic collagen degradation by CTSK maintains collagen homeostasis.

86 brane proteins are sorted into the lumen for degradation by ESCRT-dependent microautophagy.

87 nhanced (sometimes >1000 fold) resistance to degradation by four different nucleases, bovine and huma

88 and we previously reported that both PTPN14 degradation by HPV16 E7 and PTPN14 CRISPR knockout repre

89 4)Ns) have recently been shown to impact RNA degradation by inducing nucleoside tetraphosphate (Np(4)

90 lly relevant model system, we show efficient degradation by noncovalent, irreversible covalent, and r

91 Our data suggest that part of the degradation by our irreversible covalent PROTACs is driv

92 r, the activation of the proteasome-mediated degradation by PROTAC requires the formation of a ternar

93 cs may be emergent phenomena generated by NO degradation by the blood or parenchyma.

94 the interference of D/N Vif mutants with A3G degradation by wild-type Vif.

95 Our findings suggest that HSP70-mediated degradation can be safely targeted with domperidone to r

96 intensive chloroplast protein remodeling and degradation can occur, releasing large numbers of endoge

97 population and bone marrow microenvironment degradation caused by pre-transplantation radiation trea

98 ia type 1 (GA1) is an inborn error of lysine degradation characterized by a specific encephalopathy t

99 show that codepletion of RFWD3 rescues fork degradation, collapse, and cell sensitivity upon replica

100 speech facilitated comprehension under each degradation condition.

101 (-434 MtC and -423 MtC, respectively), with degradation/disturbance accounting for >75% of the losse

102 Soil degradation due to global warming, water scarcity and di

103 e deacidification, inactivation of lysosomal degradation enzymes, and disruption of antigen presentat

104 ded protein response (UPR) and ER-associated degradation (ERAD) are the primary mechanism that mainta

105 umen and are recognized by the ER-associated degradation (ERAD) pathway for removal.

106 rd1 protein complex of ER-associated protein degradation (ERAD).

107 urces, either by resource supplementation or degradation, eroded the benefits of informed nomadic mov

108 atase-mediated desensitization; however, how degradation events regulate BCR functions in GCs is uncl

109 less sensitive than wild-type (WT) enzyme to degradation evoked by DPTA, suggesting that these tyrosi

110 e hours per gram of LiFePO(4), and almost no degradation for over 50 cycles, starting with a 1x exces

111 651 by EglN1 mediated its ubiquitination and degradation governed by pVHL.

112 to successfully inhibit PTP activity through degradation has been developed.

113 criptome, translational control, and protein degradation have emerged as fundamental regulators of pr

114 MPK mobilizes Kif19a into autophagosomes for degradation in airway epithelial cells.

115 or shows a significant reduction of collagen degradation in an ex vivo pig-skin model.

116 a fork-associated protein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8

117 vitreous echodensity (R: 0.573; P < .01) and degradation in CSF (R: 0.611; P < .01).

118 enylation, is the rate-limiting step of mRNA degradation in eukaryotic cells.

119 on, but also suggested a role for carotenoid degradation in L. japonica's dynamic flower coloration.

120 s frequently contribute to organic pollutant degradation in natural and engineered systems, such as d

121 dical-mediated oxidation reactions-pollutant degradation in particular.

122 VLPs), that Vpr alone is sufficient for REAF degradation in primary macrophages.

123 ts the RdDM compotent NRPD1 for UPS-mediated degradation in rice.

124 ssue by predicting sensing and communication degradation in terms of acoustic attenuation, dispersion

125 itochondria are retrogradely transported for degradation in the cell body, the precise impact of disr

126 urnover of aged organelles through lysosomal degradation in the cell body.

127 o 5' DNA overhangs and directly blocks MRE11 degradation in vitro, and the DNA-binding ability of CST

128 Wss1/SPRTN targets DPC protein moieties for degradation, including stabilized topoisomerase-1 cleava

129 As particle size decreased, polymer degradation increased, indicating an increase in aerosol

130 at is caused by toxic accumulation of lysine degradation intermediates.

131 This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the

132 A similar RNAP II degradation is also evident in mutant ATXN3-expressing D

133 preclinical and clinical AD while mature NGF degradation is enhanced.

134 Combined biochemical and biomechanical degradation is found near the free surfaces and especial

135 resulting imbalance in protein synthesis and degradation is found to disrupt glutamatergic transmissi

136 D2 ring, work together to fuel ATP-dependent degradation is not understood.

137 altered in vivo in disease models and whose degradation is promoted by UBQLN2.

138 how aggregates are selectively targeted for degradation is unclear.

139 G within the same cell revealed that PPP2R5A degradation kinetics are comparable to those of APOBEC3G

140 ing with the antibacterial potential and the degradation kinetics indicated first-order reactions.

141 vidence that disturbed flow (DF) induces GCX degradation, leading to CTC homing to the endothelium, a

142 ylation makes cyclin L2 amenable to cellular degradation, leading to restriction of HIV replication i

143 for cytoskeletal maintenance in post-nuclear degradation lens fiber cells, perturbation of which caus

144 Overall, synthesis and degradation made equal contributions to the adaptation o

145 sfolded AAT are not required for accelerated degradation mediated by the unconventional system, furth

146 metabolomics for the analysis of tryptophan degradation metabolites in mouse serum.

147 ch as the utility of the pyrimidine (uracil) degradation metabolites in predicting 5-fluorouracil tox

148 and parkin (PRKN) in mediating mitochondrial degradation (mitophagy) reaffirmed the importance of thi

149 ools, we determined correlations between PAH degradation network data and intermediate metabolite str

150 ompounds based on their placement within the degradation network.

151 trophic outgassing, precipitation and sample degradation observed when the dispersed phase is in clos

152 support the hypothesis that Vpr induces the degradation of a factor, REAF, that impedes HIV infectio

153 s, this method will allow rapid and specific degradation of a wide range of endogenous proteins.

154 We report that Fe(2+) promotes degradation of all rRNA species of the yeast ribosome an

155 ity, by enhancing the autoubiquitination and degradation of an E3 ubiquitin ligase.

156 lease complex required for processing and/or degradation of both coding and non-coding RNAs.

157 Pharmacological degradation of BRD4-NUT results in collapse of megadomai

158 COP1 knockdown using siRNA prevents degradation of c-Jun, ETV4, and ETV5 in cells treated wi

159 Similarly, TiPARP promotes the degradation of c-Myc and estrogen receptor.

160 h and development via TIR1-dependent protein degradation of canonical AUX/IAA proteins, which normall

161 le yeast deletion mutants for defects in the degradation of cortical ER following treatment with rapa

162 The E3 ubiquitin ligase Parkin promotes the degradation of damaged mitochondria via mitophagy and mu

163 utophagy can protect stressed cancer cell by degradation of damaged proteins and organelles.

164 rmones gibberellins (GAs), which promote the degradation of DELLAs.

165 rating that Vif can concurrently mediate the degradation of distinct cellular substrates.

166 protein NEDD8 to lysine residues, interrupts degradation of DNMT3A1.

167 ys reveal that QKI-7 binds and promotes mRNA degradation of downstream targets CD144, Neuroligin 1 (N

168 lls and promote antigen processing (based on degradation of DQ-OVA, a substrate for proteases which u

169 tvaccination sera also prevented NS1-induced degradation of endothelial glycocalyx components.

170 s) are extracellular enzymes involved in the degradation of extracellular matrix (ECM) proteins.

171 e that when polyubiquitinated results in the degradation of FAAP20.

172 ecycling by inducing the internalization and degradation of ferroportin(1).

173 In the presence of amines, the degradation of glutaconaldehyde in acidic medium can be

174 e 1 (HMOX1; HO-1), an enzyme responsible for degradation of heme to carbon monoxide, bilirubin, and i

175 , GPP per unit dryland area will decrease as degradation of historical drylands outpaces the higher G

176 replication by controlling viral HA-induced degradation of host type I IFN receptor.

177 promoter analyses suggested that LEN-induced degradation of IKZF1 enables a RUNX1-GATA2 complex to dr

178 isruption of PRC2 complex formation, and the degradation of its subunits.

179 mRNA but also to an accelerated proteasomal degradation of KIF1A proteins, leading to a near depleti

180 ng mechanisms for a PRV-induced, accelerated degradation of KIF1A, a kinesin-3 motor promoting the so

181 ke cAMP, also markedly increased proteasomal degradation of long-lived proteins (the bulk of cell pro

182 uggest that synovial CG may take part in the degradation of lubricin, which could affect the patholog

183 ared to the untreated sample, indicating the degradation of melanin.

184 d that mitophagy (i.e., selective autophagic degradation of mitochondria) is also active after myotub

185 RNA entrance and facilitates 3'->5' exosomal degradation of mRNA during ribosome-associated mRNA surv

186 litated by S. aureus nuclease (Nuc)-mediated degradation of NET DNA.

187 s LDB1 and LMO2, and prevented RLIM-mediated degradation of others, such as LHX3 and TRF1.

188 s a consequence, lysosomal acidification and degradation of phagocytosed materials are impaired, caus

189 strigolactone and gibberellin biosynthesis, degradation of phospholipids and biosynthesis of glycero

190 1, an E3 ligase, promoted ubiquitination and degradation of phosphorylated SMAD3 and impaired a SMAD3

191 The functional features are associated with degradation of phytate, antioxidant capacity, exopolysac

192 Degradation of polychlorinated biphenyls (PCBs) is initi

193 ic as premature transcription termination or degradation of polyubiquitylated Pol II and its associat

194 -cell imaging studies examining Vif-mediated degradation of PPP2R5A and APOBEC3G within the same cell

195 e microphytobenthos carbon, which stimulated degradation of previously unavailable organic matter and

196 n the autophagic machinery necessary for the degradation of primary cilia.

197 e expression of phosphorylated H2AX, but not degradation of proapoptotic BAK in the cSCCs.

198 mall molecules to induce ubiquitin-dependent degradation of proteins.

199 t rescue experiment, we demonstrate that the degradation of PTPN14 is required for high-risk HPV18 E7

200 cross-linking methods reduced the enzymatic degradation of rabbit scleral tissue by MMP1.

201 TIM results in an excessive MRE11-dependent degradation of reversed forks.

202 attenuating oxidant-induced Fe(2+)-mediated degradation of rRNA.

203 ligase that leads to the ubiquitination and degradation of several transcription regulators, such as

204 sing cGMP, like raising cAMP, stimulated the degradation of short-lived cell proteins, but unlike cAM

205 providing the molecular basis for selective degradation of sizable cytosolic components.

206 ubiquitin ligase NEDD4L, which mediates the degradation of SMAD2.

207 o facilitate ubiquitin-dependent proteasomal degradation of some of the proteins it interacts with.

208 terestingly, we found that LANA enhanced the degradation of some RLIM substrates, such as LDB1 and LM

209 xes, we find that chain debranching promotes degradation of substrates modified with branched chains

210 Degradation of SUPPRESSOR OF MAX2 1 (SMAX1) after ligand

211 rement poorly investigated due to postmortem degradation of synaptic receptors.

212 ated repression and find that it accelerates degradation of target mRNAs, mediated by three N-termina

213 integrity, and decreased the enzyme-mediated degradation of the bonding interface by inhibiting colla

214 e into account processes that may accelerate degradation of the canisters, plug, and SNF itself, such

215 In Drosophila, light-dependent degradation of the clock protein TIMELESS by the blue li

216 nged heat shock response despite concomitant degradation of the covalent ligand/Hsp90 complex.

217 triggers the ubiquitin-dependent proteasomal degradation of the cytochrome P450 (P450) enzyme CYP2B6.

218 ription complex and the latter proposes that degradation of the downstream product of poly(A) signal

219 Degradation of the glycocalyx is now considered a corner

220 nd gene families potentially involved in the degradation of the hydrophobic layer and pyrolysed organ

221 We found that beam-induced degradation of the perovskite leads to an initial loss o

222 atively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled.

223 Abscisic acid enhances the COP1-mediated degradation of these PP2Cs.

224 e role of the GCX, neuraminidase induced the degradation of WGA-labeled GCX under UF cell culture con

225 o and in vivo and induces ubiquitination and degradation of WRN in the ubiquitin-proteasome pathway.

226 Since spironolactone causes degradation of xeroderma pigmentosum group B-complementi

227 rve (accuracy within 8% and 2% for measuring degradations of 5% and 15% product, respectively) was th

228 f MOFs in the elimination (adsorption and/or degradation) of EOCs from water, classifying them by the

229 ed light on the importance of WNK's cellular degradation on renal ion transport.

230 better understanding of battery cycling and degradation, operando analytical measurements are invalu

231 chitin unaccompanied by noticeable backbone degradation or deacetylation.

232 Autophagy is an intracellular degradation pathway crucial to maintaining cellular home

233 Direct photolysis can be an important degradation pathway for sunlight-absorbing compounds in

234 eticulum omega-oxidation, a minor fatty acid degradation pathway known to be stimulated by C(12) accu

235 ic downregulation of enzymes in the tyrosine degradation pathway significantly extends Drosophila lif

236 gy has prevented the identification of other degradation pathways.

237 stances where a decrease in protein-specific degradation primarily accounted for the increase in abun

238 while the reversible covalent PROTACs drive degradation primarily by covalent engagement.

239 ate states and populations during the active degradation process in solution remain scarce.

240 SA and CSB as part of a ubiquitin/proteasome degradation process involved in transcription, DNA repai

241 This degradation process will at the same time also allow for

242 d catalytic turnover, but also understanding degradation processes of the photocatalytic active mater

243 radation of cysteine sulfinic acid, a (photo)degradation product of cysteine, to sulfate (SO(4)(2-)).

244 tin(II) halide perovskites as well as their degradation products and related phases.

245 However, studying the effects of these degradation products has proven challenging because of t

246 ic stress, such as in obesity, the resulting degradation products may play a detrimental role, which

247 -methyl-2-nitrosopropane (MNP), one of three degradation products of the PBN-peroxy-adduct.

248 sequencing strategies for mixtures of lignin degradation products.

249 ing proteins, the cellular protein level and degradation rate of HO2 are independent of heme binding

250 Calculated degradation rates were slower for DDs and faster for dih

251 d 95% within three hours; the adsorption and degradation ratios reached 46% and 49%, respectively.

252 This suggested that sugar degradation reactions were found responsible for alpha-d

253 climate change, biodiversity loss, and land degradation require transformative interventions in the

254 se laforin or its interacting partner malin, degradation-resistant abnormally structured insoluble gl

255 Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as nu

256 estingly, while protection of bound TFs from degradation slows the time-scale of fluctuations in the

257 antiicing surfaces remain elusive because of degradation such as mechanical wearing.

258 stically larger enhancements during spectral degradation, suggesting a condition-specific facilitatio

259 Using an acute degradation system, we found that the histone acetyltran

260 perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantage

261 nger wavelengths under operating conditions, degradation that occurs due to phase separation when mix

262 the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegen

263 at Thr58, leading to MYC ubiquitination and degradation, thereby regulating MYC target genes.

264 dable hydrogel is presented, achieving rapid degradation through radical addition-fragmentation chain

265 PCH1 and PCHL interact with COP1 and undergo degradation through the 26S proteasome pathway in the da

266 ER 1 (OsVOZ1) and OsVOZ2, and promotes their degradation through the 26S proteasome pathway.

267 h in NUB1 function from targeted proteasomal degradation to a role in autophagy.

268 DDR kinase Rad53(CHK1/CHK2) controls histone degradation to assist DNA repair.

269 esicular system was too stable to surfactant degradation to be maintained out of equilibrium.

270 eadily transferred to the catalytic site for degradation to facilitate turnover but can also equilibr

271 ovel mechanism by which SLB1 targets BS1 for degradation to regulate M. truncatula organ size and sho

272 heries is needed to quantitatively link reef degradation to stock production parameters is needed.

273 inated PHGDH at lysine 330, leading to PHGDH degradation to suppress serine synthesis.

274 e results suggest that Nep1 targets Amnesiac degradation to terminate its signaling function.

275 Targeted protein degradation (TPD) refers to the use of small molecules t

276 n-proteasome system, which regulates protein degradation, trafficking, and signaling events in the ce

277 nding to IRP2 to effect its oxygen-dependent degradation, unveiling a novel and previously unrecogniz

278 lation increases MDM2 autoubiquitination and degradation upon DNA damage, whereas S429A substitution

279 sp70 chaperones Ssa1 and Ssa2 in nuclear PQC degradation varies with the substrate.

280 gulf alpha-synuclein into autophagosomes for degradation via selective autophagy (termed synucleinpha

281 ne, cytosol, and nucleus, targeting them for degradation via the endosomal/vacuolar RSL1-dependent pa

282 for dioxgen availability-dependent HIF-alpha degradation via the ubiquitin proteasome system.

283 obal phenomenon that is associated with land degradation via xerification, which replaces grasses wit

284 activity, ubiquitination but not proteasomal degradation was critical for structural and functional p

285 When protein degradation was inhibited, we observed a coordinate dram

286 Biological degradation was investigated in resting cell suspensions

287 group (P < 0.05), whereas gingival collagen degradation was like the ligature group (P > 0.05).

288 ere incubated with exogenous CG and lubricin degradation was monitored using western blot, staining b

289 Darkness and salt stress triggered BPM1 degradation, whereas elevated temperature enhanced BPM1

290 receptor coactivator 3 (SRC3) and BRD4, for degradation, whereas it might function as an oncoprotein

291 erization coupled to highly specific protein degradation, which in the case of BCL6 leads to increase

292 trategies to mitigate catalyst and electrode degradation, which is fundamentally essential to make M-

293 horylation: phosphorylation at Thr58 signals degradation while Ser62 phosphorylation leads to its sta

294 , including improved resistance to enzymatic degradation, while remaining nontoxic.

295 Small-molecule targeted RNA degradation will thus provide a general route to affect

296 [4Fe4S] cofactor is susceptible to oxidative degradation with aggregation of apo species.

297 ed Pol II kinetics by coupling rapid subunit degradation with orthogonal experimental readouts.

298 rness the potential of light-induced protein degradation with photoactive bifunctional molecules are

299 secreted and membrane proteins for lysosomal degradation, with broad implications for biochemical res

300 Testing showed complete degradation within 46 days, proving composting to be a f